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ID2 Gene

protein-coding   GIFtS: 64
GCID: GC02P008818

Inhibitor Of DNA Binding 2, Dominant Negative Helix-Loop-Helix...

  See ID2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inhibitor Of DNA Binding 2, Dominant Negative Helix-Loop-Helix
Protein1 2
     DNA-Binding Protein Inhibitor ID-22
Cell Growth-Inhibiting Gene 81 2     DNA-Binding Protein Inhibitor ID22
Class B Basic Helix-Loop-Helix Protein 262 3     Helix-Loop-Helix Protein ID22
bHLHb262 3     Inhibitor Of Differentiation 22
GIG82     BHLHB263
ID2A2     Inhibitor Of DNA Binding 23
ID2H2     

External Ids:    HGNC: 53611   Entrez Gene: 33982   Ensembl: ENSG000001157387   OMIM: 6003865   UniProtKB: Q023633   

Export aliases for ID2 gene to outside databases

Previous GC identifers: GC02P008605 GC02P008873 GC02P008843 GC02P008772


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ID2 Gene:
The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are
transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the
inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a
dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein
may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome
3. (provided by RefSeq, Aug 2011)

GeneCards Summary for ID2 Gene:
ID2 (inhibitor of DNA binding 2, dominant negative helix-loop-helix protein) is a protein-coding gene. Diseases associated with ID2 include congenital hydronephrosis. GO annotations related to this gene include ion channel binding and protein dimerization activity. An important paralog of this gene is ID1.

UniProtKB/Swiss-Prot: ID2_HUMAN, Q02363
Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form
heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific
gene expression

Gene Wiki entry for ID2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005334.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ID2 gene promoter:
         IRF-2   p53   SREBP-1c   FOXO4   Egr-1   Nkx2-5   SREBP-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ID2 promoter sequence
   Search Chromatin IP Primers for ID2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ID2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25   Ensembl cytogenetic band:  2p25.1   HGNC cytogenetic band: 2p25

ID2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ID2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P008818:  view genomic region     (about GC identifiers)

Start:
8,818,975 bp from pter      End:
8,824,583 bp from pter
Size:
5,609 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ID2_HUMAN, Q02363 (See protein sequence)
Recommended Name: DNA-binding protein inhibitor ID-2  
Size: 134 amino acids; 14917 Da
Subunit: Heterodimer with other HLH proteins. Interacts with GATA4, IFI204 and NKX2-5 (By similarity). Interacts
with NR0B2
Developmental stage: Found in most early fetal tissues but not in the corresponding mature tissues
1 PDB 3D structure from and Proteopedia for ID2:
4AYA (3D)    

Explore the universe of human proteins at neXtProt for ID2: NX_Q02363

Explore proteomics data for ID2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys12
  • Modification sites at PhosphoSitePlus

  • See ID2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002157.2  
    ENSEMBL proteins: 
     ENSP00000234091   ENSP00000385465   ENSP00000379585  

    ID2 Human Recombinant Protein Products:

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    Novus Biologicals ID2 Proteins
    Novus Biologicals ID2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ID2
    Cloud-Clone Corp. Proteins for ID2

     
    Search eBioscience for Proteins for ID2 

     
    antibodies-online proteins for ID2 (11 products) 

     
    antibodies-online peptides for ID2

    ID2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ID2
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    antibodies-online antibodies for ID2 (63 products) 

    ID2 Assay Products:

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    Cloud-Clone Corp. ELISAs for ID2
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    antibodies-online kits for ID2 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    2 InterPro protein domains:
     IPR026052 DNA-bd_prot-inh
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry Q02363

    ProtoNet protein and cluster: Q02363

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: ID2_HUMAN, Q02363
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Find genes that share domains with ID2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ID2_HUMAN, Q02363
    Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form
    heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific
    gene expression

         Genatlas biochemistry entry for ID2:
    inhibitor of DNA binding 2,putative transcription regulator,expressed during early development,inhibiting
    transcription factors of the basic helix loop helix family

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10915743
    GO:0044325ion channel binding IPI16311606
    GO:0046983protein dimerization activity IEA--
         
    Find genes that share ontologies with ID2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ID2:
     Cell cycle / mitosis defect  Increased cell death HMECs cel 

         Selected MGI mutant phenotypes (inferred from 11 alleles(MGI details for Id2) (see all 17):
     adipose tissue  behavior/neurological  cellular  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  immune system  integument  mortality/aging 
     nervous system  no phenotypic analysis  normal  renal/urinary system  reproductive system 

    Find genes that share phenotypes with ID2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ID2: Id2tm1Jdu Id2tm1Mcha Id2tm1Yyk Id2tm1Ago

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ID2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ID2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ID2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ID2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ID2:
    hsa-mir-378a-3p (MIRT043878), hsa-mir-215-5p (MIRT024314), hsa-mir-103a-3p (MIRT007062), hsa-mir-124-3p (MIRT023177), hsa-mir-192-5p (MIRT026921), hsa-mir-9-5p (MIRT007060)

    Block miRNA regulation of human, mouse, rat ID2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ID2 (see all 20):
    hsa-miR-4311 hsa-miR-300 hsa-miR-340 hsa-miR-583 hsa-miR-1276 hsa-miR-298 hsa-miR-330-3p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidID2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ID2
    Predesigned siRNA for gene silencing in human, mouse, rat ID2

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for ID2
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    GenScript: all cDNA clones in your preferred vector: ID2 (NM_001510)
    Sino Biological Human cDNA Clone for ID2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ID2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ID2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ID2
    Browse ESI BIO Cell Lines and PureStem Progenitors for ID2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ID2

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA6-11198) for ID2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ID2_HUMAN, Q02363: Cytoplasm (By similarity). Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton1
    extracellular1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737colocalizes with cytoplasm IDA16311606
    GO:0005813centrosome IDA--

    Find genes that share ontologies with ID2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ID2 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    2Validated targets of C-MYC transcriptional repression
    Validated targets of C-MYC transcriptional repression
    3Validated targets of C-MYC transcriptional activation
    Validated targets of C-MYC transcriptional activation
    4Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    5TGF-beta signaling pathway (KEGG)
    TGF-beta signaling pathway


    Find genes that share SuperPaths with ID2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ID2
        Human Early Embryo Development

    1 Cell Signaling Technology (CST) Pathway for ID2
        Wnt / Hedgehog / Notch

    Selected BioSystems Pathways for ID2 (see all 6)
        Id Signaling Pathway
    HIF-1-alpha transcription factor network
    Validated targets of C-MYC transcriptional repression
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Validated targets of C-MYC transcriptional activation



    3 Kegg Pathways  (Kegg details for ID2):
        TGF-beta signaling pathway
    Hippo signaling pathway
    Transcriptional misregulation in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ID2: 
              Notch Signaling Targets in human mouse rat
              WNT Signaling Targets in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              TGFB Signaling Targets in human mouse rat
              T Helper Cell Differentiation in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ID2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ID2 (Q023631, 2, 3 ENSP000002340914) via UniProtKB, MINT, STRING, and/or I2D (see all 96)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNDBP1O952731, 2EBI-713450,EBI-748961 MINT-8396328 MINT-8396313 MINT-8396281 MINT-8396356
    UNC119Q134322, 3MINT-64029 I2D: score=5 
    LRIF1Q5T3J32, 3MINT-64030 I2D: score=4 
    TCF3P159233, ENSP000002629654I2D: score=5 STRING: ENSP00000262965
    MYOD1P151723, ENSP000002500034I2D: score=3 STRING: ENSP00000250003
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 47):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001656metanephros development IEA--
    GO:0001779natural killer cell differentiation IEA--
    GO:0002521leukocyte differentiation ----
    GO:0003149membranous septum morphogenesis IEA--

    Find genes that share ontologies with ID2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ID2

    9 Novoseek inferred chemical compound relationships for ID2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 21.4 9 19260835 (2), 15831462 (2), 17393418 (1), 19180920 (1)
    phosphatidylinositol 11.1 1 16150928 (1)
    bromodeoxyuridine 9.61 1 19609365 (1)
    oligonucleotide 9.04 1 12670915 (1)
    retinoic acid 8.53 7 17310985 (2), 16549780 (1), 14582708 (1)
    butyrate 7.36 1 10330158 (1)
    calcitriol 5.17 1 16007183 (1)
    estrogen 0 2 15809228 (1), 19257909 (1)
    dexamethasone 0 3 11317672 (2), 12424200 (1)



    Find genes that share compounds with ID2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ID2 gene: 
    NM_002166.4  

    Unigene Cluster for ID2:

    Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
    Hs.180919  [show with all ESTs]
    Unigene Representative Sequence: NM_002166
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000234091(uc002qza.3) ENST00000331129 ENST00000472142 ENST00000396290

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ID2 (see all 20):
    hsa-miR-4311 hsa-miR-300 hsa-miR-340 hsa-miR-583 hsa-miR-1276 hsa-miR-298 hsa-miR-330-3p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidID2 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: ID2 (NM_001510)
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      QuantiTect SYBR Green Assays in human, mouse, rat ID2
      QuantiFast Probe-based Assays in human, mouse, rat ID2
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    eBioscience FlowRNA Probe Sets ( VA6-11198) for ID2 

    Additional mRNA sequence: 

    AK222682.1 BC030639.2 D13891.1 M97796.1 

    15 DOTS entries:

    DT.102824856  DT.92437989  DT.100818571  DT.100818572  DT.100818580  DT.419995  DT.100722779  DT.92437995 
    DT.95334744  DT.100697819  DT.100818570  DT.120992827  DT.92437991  DT.100818582  DT.91990899 

    Selected AceView cDNA sequences (see all 483):

    AA128163 AA228010 BM797416 BF035729 AA814201 CA944874 BU742429 CR611001 
    AI336033 AI334315 BU682674 NM_002166 AA889009 AI342053 AI051907 BM126985 
    CA418887 N26640 AL541358 AI863093 AA706083 BI962513 BM854392 BE047841 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ID2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGAAGTCA
    ID2 Expression
    About this image


    ID2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 34) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Pre-myelinating Oligodendrocyte Cells Spinal Cord White Matter
             Cerebral Cortex
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             Distal Lung Progenitor Cells Lung Bud
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             Presumptive Podocytes Podocyte Layer
             Interstitial Stroma
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Oligodendrocyte Precursor Cells Caudal Ganglionic Eminence
             Metencephalon
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
    ID2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ID2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.180919

    UniProtKB/Swiss-Prot: ID2_HUMAN, Q02363
    Tissue specificity: Highly expressed in early fetal tissues, including those of the central nervous system

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ID2: 
              Notch Signaling Targets in human mouse rat
              WNT Signaling Targets in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              TGFB Signaling Targets in human mouse rat
              T Helper Cell Differentiation in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat ID2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ID2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ID2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Id21 , 5 inhibitor of DNA binding 21, 5 95.02(n)1
    98.51(a)1
      12 (8.57 cM)5
    159021  NM_010496.31  NP_034626.11 
     250938015 
    chicken
    (Gallus gallus)
    Aves ID21 inhibitor of DNA binding 2, dominant negative helix-loop-helix more 86.32(n)
    94.03(a)
      395852  NM_205002.1  NP_990333.1 
    lizard
    (Anolis carolinensis)
    Reptilia ID26
    inhibitor of DNA binding 2, dominant negative heli...
    85(a)
    1 ↔ 1
    1(148970558-148977078)
    African clawed frog
    (Xenopus laevis)
    Amphibia id22 Id2 protein 81.46(n)    BC041527.1 
    zebrafish
    (Danio rerio)
    Actinopterygii id22 inhibitor of DNA binding 2, dominant negative helix-loop-helix more 78.85(n)   266599  AY398363.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta emc6
    extra macrochaetae
    7(a)
    1 → many
    3L(749400-753492)


    ENSEMBL Gene Tree for ID2 (if available)
    TreeFam Gene Tree for ID2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ID2 gene
    ID12  ID32  ID42  
    4 SIMAP similar genes for ID2 using alignment to 2 protein entries:     ID2_HUMAN (see all proteins):
    ID2B    ID4    ID1    ID3

    Find genes that share paralogs with ID2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ID2
    PGOHUM00000250241


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ID2 (see all 38)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1404871841,2
    C--8824194(+) CACTT-/AAATG 
            
    AAGTC
    1 -- ut310--------
    rs1920553921,2
    --8824334(+) GAGATA/GTCTAT 1 -- ut310--------
    rs1849499201,2
    --8824368(+) TGTACC/TTATTC 1 -- ut310--------
    rs1503333631,2
    --8824470(+) TATTT-/CAGAGGA 1 -- ut310--------
    rs1477636391,2
    --8824569(+) TAAAAC/GATGTC 1 -- ut310--------
    rs1897487251,2
    --8824586(+) CAATAA/CCTGAA 1 -- ds50010--------
    rs101828381,2
    C--8824669(+) CCCCCC/ACACAC 1 -- ds50012Minor allele frequency- A:0.00NA 4
    rs67245531,2
    C,F--8824684(+) ACACAT/CATTGT 1 -- ds50011Minor allele frequency- C:0.00WA 2
    rs1843001511,2
    --8824765(+) TCTTAC/TCAGAT 1 -- ds50010--------
    rs1895580001,2
    --8824766(+) CTTATC/GAGATG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ID2 (8818975 - 8824583 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ID2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv873616CNV Loss21882294
    nsv873614CNV Loss21882294
    nsv873615CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ID2
    DNA2.0 Custom Variant and Variant Library Synthesis for ID2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600386    OMIM disorders: --

    1 disease for ID2:    
    About MalaCards
    congenital hydronephrosis

    1 disease from the University of Copenhagen DISEASES database for ID2:
    Retinoblastoma

    Find genes that share disorders with ID2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ID2 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 56.4 13 11034201 (2), 15831462 (1), 16733829 (1), 16549780 (1) (see all 10)
    ewings sarcoma 41.7 10 16869242 (7), 12527902 (3)
    tumors 38.2 45 20388805 (5), 12545167 (3), 16549780 (3), 12447693 (2) (see all 24)
    cancer 12.2 7 12447693 (1), 16733829 (1), 9731481 (1), 18413820 (1) (see all 6)
    lymphoma 10.4 7 15492249 (2), 18085637 (1), 8632670 (1)
    colon carcinoma 3.22 5 11572874 (2), 16007183 (1)
    leukemia 0 2 8632670 (1), 15492249 (1)
    primary tumor 0 1 12447693 (1)
    glioma 0 2 7622574 (1), 12007145 (1)
    hypertrophy 0 2 16002773 (1), 15601750 (1)

    Genetic Association Database (GAD): ID2
    Human Genome Epidemiology (HuGE) Navigator: ID2 (6 documents)

    Export disorders for ID2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ID2 gene, integrated from 10 sources (see all 238):
    (articles sorted by number of sources associating them with ID2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. (PubMed id 8294468)1, 2, 3 Hara E....Oda K. (J. Biol. Chem. 1994)
    2. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    3. Case-control study of six genes asymmetrically expressed in the two cerebral hemispheres: association of BAIAP2 with attention-deficit/hyperactivity disorder. (PubMed id 19733838)1, 4 RibasAcs M....Cormand B. (Biol. Psychiatry 2009)
    4. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    5. Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD. (PubMed id 14752053)1, 2 Kim J.Y.... Choi H.S. (Mol. Endocrinol. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. A human Id-like helix-loop-helix protein expressed during early development. (PubMed id 1741406)1, 2 Biggs J.... Israel M.A. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    8. Id2 promotes the invasive growth of MCF-7 and SKOV-3 cells by a novel mechanism independent of dimerization to basic helix-loop-helix factors. (PubMed id 19257909)1, 9 Meng Y....Han W. (BMC Cancer 2009)
    9. Regulation of Id2 expression in EL4 T lymphoma cells overexpressing growth hormone. (PubMed id 19010462)1, 9 Weigent D.A. (Cell. Immunol. 2009)
    10. Id2 leaves the chromatin of the E2F4-p130-controlled c-myc promoter during hepatocyte priming for liver regeneration. (PubMed id 16776654)1, 9 RodrA-guez J.L....Torres L. (Biochem. J. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3398 HGNC: 5361 AceView: ID2 Ensembl:ENSG00000115738 euGenes: HUgn3398
    ECgene: ID2 Kegg: 3398 H-InvDB: ID2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ID2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ID2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ID2 gene:
    Search GeneIP for patents involving ID2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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