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Aliases for ID2 Gene

Aliases for ID2 Gene

  • Inhibitor Of DNA Binding 2, HLH Protein 2 3 5
  • Inhibitor Of Differentiation 2 2 3 4
  • Inhibitor Of DNA Binding 2, Dominant Negative Helix-Loop-Helix Protein 2 3
  • Class B Basic Helix-Loop-Helix Protein 26 3 4
  • Cell Growth-Inhibiting Gene 8 2 3
  • BHLHb26 3 4
  • DNA-Binding Protein Inhibitor ID-2 3
  • DNA-Binding Protein Inhibitor ID2 3
  • Helix-Loop-Helix Protein ID2 3
  • Inhibitor Of DNA Binding 2 4
  • GIG8 3
  • ID2A 3
  • ID2H 3

External Ids for ID2 Gene

Previous GeneCards Identifiers for ID2 Gene

  • GC02P008605
  • GC02P008873
  • GC02P008843
  • GC02P008818

Summaries for ID2 Gene

Entrez Gene Summary for ID2 Gene

  • The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]

GeneCards Summary for ID2 Gene

ID2 (Inhibitor Of DNA Binding 2, HLH Protein) is a Protein Coding gene. Diseases associated with ID2 include Ewing Sarcoma and Diamond-Blackfan Anemia. Among its related pathways are Validated targets of C-MYC transcriptional repression and Validated targets of C-MYC transcriptional activation. GO annotations related to this gene include protein dimerization activity and ion channel binding. An important paralog of this gene is ID4.

UniProtKB/Swiss-Prot for ID2 Gene

  • Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.

Gene Wiki entry for ID2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ID2 Gene

Genomics for ID2 Gene

Regulatory Elements for ID2 Gene

Enhancers for ID2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G008300 1.8 FANTOM5 Ensembl ENCODE dbSUPER 17.7 -376.2 -376211 3.4 PKNOX1 ATF1 WRNIP1 SIN3A YY1 TCF12 ELK1 GATA2 ZNF143 ZNF207 ID2 ID2-AS1 LINC00298 LINC00299
GH02G008533 2 FANTOM5 Ensembl ENCODE dbSUPER 15.5 -141.4 -141353 7.1 MLX ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF263 SP3 NFYC MEF2D ID2 ID2-AS1 KIDINS220 ENSG00000231435 LINC00299
GH02G008312 1.8 FANTOM5 Ensembl ENCODE dbSUPER 15.7 -365.7 -365650 2.0 PKNOX1 ATF1 WRNIP1 YBX1 YY1 TCF12 ELK1 ZNF143 ZNF207 FOS ID2 ID2-AS1 LINC00298 LINC00299
GH02G008499 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.7 -178.1 -178072 1.7 FOXA2 MLX ARID4B RAD21 ZEB1 RARA FOS CEBPB GATAD2B ZEB2 ID2 ID2-AS1 ENSG00000231435 LINC00299
GH02G008484 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13 -190.7 -190723 6.9 PKNOX1 FOXA2 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ID2 ID2-AS1 ENSG00000231435 LINC00299
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ID2 on UCSC Golden Path with GeneCards custom track

Promoters for ID2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000112469 155 1601 PKNOX1 ARNT ARID4B SIN3A ZNF48 YY1 ZNF766 GLIS2 KDM4B ZNF263

Genomic Location for ID2 Gene

Chromosome:
2
Start:
8,678,845 bp from pter
End:
8,684,453 bp from pter
Size:
5,609 bases
Orientation:
Plus strand

Genomic View for ID2 Gene

Genes around ID2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ID2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ID2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ID2 Gene

Proteins for ID2 Gene

  • Protein details for ID2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02363-ID2_HUMAN
    Recommended name:
    DNA-binding protein inhibitor ID-2
    Protein Accession:
    Q02363

    Protein attributes for ID2 Gene

    Size:
    134 amino acids
    Molecular mass:
    14917 Da
    Quaternary structure:
    • Heterodimer with other HLH proteins. Interacts with GATA4, IFI204 and NKX2-5 (By similarity). Interacts with NR0B2. Interacts with CLOCK and ARNTL/BMAL1.

    Three dimensional structures from OCA and Proteopedia for ID2 Gene

neXtProt entry for ID2 Gene

Post-translational modifications for ID2 Gene

  • Ubiquitination at isoforms=12
  • Modification sites at PhosphoSitePlus

Other Protein References for ID2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ID2 Gene

Domains & Families for ID2 Gene

Gene Families for ID2 Gene

Protein Domains for ID2 Gene

Graphical View of Domain Structure for InterPro Entry

Q02363

UniProtKB/Swiss-Prot:

ID2_HUMAN :
  • The bHLH domain is essential for its repressor activity towards the CLOCK-ARNTL/BMAL1 heterodimer.
Domain:
  • The bHLH domain is essential for its repressor activity towards the CLOCK-ARNTL/BMAL1 heterodimer.
genes like me logo Genes that share domains with ID2: view

Function for ID2 Gene

Molecular function for ID2 Gene

GENATLAS Biochemistry:
inhibitor of DNA binding 2,putative transcription regulator,expressed during early development,inhibiting transcription factors of the basic helix loop helix family
UniProtKB/Swiss-Prot Function:
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.

Gene Ontology (GO) - Molecular Function for ID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10915743
GO:0044325 ion channel binding IPI 16311606
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with ID2: view
genes like me logo Genes that share phenotypes with ID2: view

Animal Models for ID2 Gene

MGI Knock Outs for ID2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ID2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ID2 Gene

Localization for ID2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ID2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ID2 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
extracellular 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16311606
GO:0005737 colocalizes_with cytoplasm IDA,IEA 16311606
GO:0005829 cytosol IDA 16311606
GO:0043234 protein complex ISS --
genes like me logo Genes that share ontologies with ID2: view

Pathways & Interactions for ID2 Gene

genes like me logo Genes that share pathways with ID2: view

SIGNOR curated interactions for ID2 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ID2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001656 metanephros development IEA --
GO:0001779 natural killer cell differentiation IEA --
GO:0001966 thigmotaxis IEA --
GO:0002521 leukocyte differentiation IEA --
GO:0003149 membranous septum morphogenesis IEA --
genes like me logo Genes that share ontologies with ID2: view

Drugs & Compounds for ID2 Gene

(4) Drugs for ID2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for ID2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ID2: view

Transcripts for ID2 Gene

Unigene Clusters for ID2 Gene

Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ID2

Alternative Splicing Database (ASD) splice patterns (SP) for ID2 Gene

No ASD Table

Relevant External Links for ID2 Gene

GeneLoc Exon Structure for
ID2
ECgene alternative splicing isoforms for
ID2

Expression for ID2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ID2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ID2 Gene

This gene is overexpressed in Artery - Tibial (x6.6) and Liver (x4.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ID2 Gene



NURSA nuclear receptor signaling pathways regulating expression of ID2 Gene:

ID2

SOURCE GeneReport for Unigene cluster for ID2 Gene:

Hs.180919

mRNA Expression by UniProt/SwissProt for ID2 Gene:

Q02363-ID2_HUMAN
Tissue specificity: Highly expressed in early fetal tissues, including those of the central nervous system.

Evidence on tissue expression from TISSUES for ID2 Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Lung(4.7)
  • Thyroid gland(3.2)
  • Bone marrow(2.9)
  • Blood(2.6)
  • Lymph node(2.6)
  • Muscle(2.6)
  • Spleen(2.6)
  • Intestine(2.5)
  • Kidney(2.4)
  • Heart(2.2)
  • Skin(2.2)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with ID2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ID2 Gene

Orthologs for ID2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ID2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ID2 34 35
  • 99.54 (n)
oppossum
(Monodelphis domestica)
Mammalia ID2 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Id2 34 16 35
  • 95.02 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ID2 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ID2 34 35
  • 94.53 (n)
rat
(Rattus norvegicus)
Mammalia Id2 34
  • 94.03 (n)
chicken
(Gallus gallus)
Aves ID2 34 35
  • 86.32 (n)
lizard
(Anolis carolinensis)
Reptilia ID2 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia id2 34
  • 79.13 (n)
MGC75823 34
African clawed frog
(Xenopus laevis)
Amphibia id2 34
zebrafish
(Danio rerio)
Actinopterygii id2a 34 35
  • 77.61 (n)
id2b 35
  • 60 (a)
OneToMany
id2 34
fruit fly
(Drosophila melanogaster)
Insecta emc 35
  • 7 (a)
OneToMany
Species where no ortholog for ID2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ID2 Gene

ENSEMBL:
Gene Tree for ID2 (if available)
TreeFam:
Gene Tree for ID2 (if available)

Paralogs for ID2 Gene

Paralogs for ID2 Gene

(4) SIMAP similar genes for ID2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ID2 Gene

genes like me logo Genes that share paralogs with ID2: view

Variants for ID2 Gene

Sequence variations from dbSNP and Humsavar for ID2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000021926 -- 8,684,237(+) ATGTA(C/T)TTATT utr-variant-3-prime
rs1000098881 -- 8,680,330(+) CCTCC(G/T)CAAAC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000154781 -- 8,680,184(+) CATGC(A/G)CACAA intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000207077 -- 8,680,023(+) GAAGA(A/G)CTGCA intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000553136 -- 8,683,470(+) GATTG(G/T)GTTGG intron-variant, upstream-variant-2KB

Variation tolerance for ID2 Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ID2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ID2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ID2 Gene

Disorders for ID2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ID2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ewing sarcoma
  • neuroepithelioma
diamond-blackfan anemia
  • diamond-blackfan anemia 1
- elite association - COSMIC cancer census association via MalaCards
Search ID2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ID2

Genetic Association Database (GAD)
ID2
Human Genome Epidemiology (HuGE) Navigator
ID2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ID2
genes like me logo Genes that share disorders with ID2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ID2 Gene

Publications for ID2 Gene

  1. Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. (PMID: 8294468) Hara E. … Oda K. (J. Biol. Chem. 1994) 2 3 4 64
  2. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty S.E. … . (PLoS Genet. 2010) 3 46 64
  3. The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression. (PMID: 20861012) Ward S.M. … Duffield G.E. (J. Biol. Chem. 2010) 3 4 64
  4. Id2 promotes tumor cell migration and invasion through transcriptional repression of semaphorin 3F. (PMID: 20388805) Coma S. … Klagsbrun M. (Cancer Res. 2010) 3 22 64
  5. Synergy between IL-15 and Id2 promotes the expansion of human NK progenitor cells, which can be counteracted by the E protein HEB required to drive T cell development. (PMID: 20483740) Schotte R. … Blom B. (J. Immunol. 2010) 3 22 64

Products for ID2 Gene

  • Addgene plasmids for ID2

Sources for ID2 Gene

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