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ID2 Gene

protein-coding GIFtS: 65

GC02P008772

inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
GIG8 ^¹, ²
ID2A ^²
ID2H ^²
MGC26389 ^²
OTTHUMP00000140258 ^²
bHLHb26 ^¹, ²

Descriptions
DNA-binding protein inhibitor ID2 ^²
Inhibitor of DNA binding 2 ^², ³
cell growth-inhibiting gene 8 ^²
helix-loop-helix protein ID2 ^²
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein ^²
inhibitor of differentiation 2 ^²

External Ids
HGNC: 5361¹
Entrez Gene: 3398²
UniProtKB: Q02363³
Ensembl: ENSG00000115738⁷

Search outside databases for aliases for ID2 gene

Previous GC identifers: GC02P008605 GC02P008873 GC02P008843

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for ID2:

The protein encoded by this gene belongs to the inhibitor of DNA binding (ID) family, members of

which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic

domain. Members of the ID family inhibit the functions of basic helix-loop-helix transcription

factors in a dominant-negative manner by suppressing their heterodimerization partners through the

HLH domains. This protein may play a role in negatively regulating cell differentiation. A

pseudogene has been identified for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: ID2_HUMAN, Q02363

Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able

to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an

inhibitor of tissue-specific gene expression

Gene Wiki entry for ID2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ID2 gene

Entrez Gene cytogenetic band: 2p25 Ensembl cytogenetic band: 2p25.1 HGNC cytogenetic band: 2p25

ID2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P008772: (about GC identifiers)

Start:	8,736,426 bp from pter
End:	8,742,034 bp from pter
Size:	5,609 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_005334.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ID2_HUMAN, Q02363 (See protein sequence)

Recommended Name: DNA-binding protein inhibitor ID-2

Size: 134 amino acids; 14917 Da

Subunit: Heterodimer with other HLH proteins

Subcellular location: Nucleus

Developmental stage: Found in most early fetal tissues but not in the corresponding mature tissues

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002157.2

ENSEMBL proteins:

ENSP00000234091 ENSP00000385465 ENSP00000379585

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ID2)
	Human Recombinant Proteins from Abnova (ID2)

OriGene Purified Recombinant Human Protein: ID2

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

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Antibodies for ID2:

	Invitrogen Antibodies for ID2
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ID2
	R&D Systems Antibodies for ID2
	Cell Signaling Technology (CST) Antibodies for ID2
	Antibodies from Abcam (ID2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ID2)
	Novus Biologicals Antibodies for ID2

Assays for ID2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q02363

ProtoNet protein and cluster: Q02363

1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: ID2_HUMAN, Q02363

Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ID2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ID2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002166

Applied Biosystems Silencer® siRNAs for ID2

Sigma-Aldrich siRNA for ID2

Sigma-Aldrich shRNA for ID2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ID2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002166
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002166
untagged cDNA clone in CMV expression vector: NM_002166

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002166

UniProtKB/Swiss-Prot: ID2_HUMAN, Q02363

Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able

to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an

inhibitor of tissue-specific gene expression

Genatlas biochemistry entry for ID2:

inhibitor of DNA binding 2,putative transcription regulator,expressed during early

development,inhibiting transcription factors of the basic helix loop helix family

15 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Id2):

adipose tissue	behavior/neurological	cellular	digestive/alimentary	endocrine/exocrine gland
growth/size	hematopoietic system	immune system	lethality-postnatal	life span-post-weaning/aging
nervous system	renal/urinary system	reproductive system	taste/olfaction	tumorigenesis

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	10915743 15249128
GO:0016564	transcription repressor activity	IDA	14627819

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for ID2

5/48 Interacting proteins for ID2 (Q02363^{1, 2} ENSP00000234091³) via UniProtKB, MINT, and/or STRING (see all 48 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TCF3	P15923-1¹, ENSP00000262965³	EBI-713450, EBI-769645 STRING (score=.996)
UNC119	Q13432²	MINT-64029
TCF4	ENSP00000346440³	STRING (score=.984)
MYOG	ENSP00000241651³	STRING (score=.975)
NKX2-5	ENSP00000327758³	STRING (score=.97)

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0007275	multicellular organismal development	TAS	1741406
GO:0007507	heart development	IEA	--
GO:0016481	negative regulation of transcription	IDA	14627819
GO:0043353	enucleate erythrocyte differentiation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ID2
2 Novoseek chemical compound relationships for ID2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
phosphatidylinositol	13.30	1	16150928 (1)
oligonucleotide	11.10	1	12670915 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ID2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ID2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002166

Sigma-Aldrich siRNA for ID2

Sigma-Aldrich shRNA for ID2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002166

REFSEQ mRNAs for ID2 gene:

NM_002166.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002166

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002166
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002166
                                 untagged cDNA clone in CMV expression vector: NM_002166

Additional cDNA sequence:

AK222682.1 AK311988.1 AY634687.1 BC030639.2 CR607131.1 CR611001.1 CR614653.1 CR620423.1

CR620531.1 CR623038.1 CR626410.1 D13891.1 M97796.1

18 DOTS entries:

DT.102824856 DT.92437989 DT.100818571 DT.100818572 DT.100818580 DT.100818582 DT.419995 DT.100722779

DT.95334744 DT.100818570 DT.92437995 DT.100697819 DT.100818576 DT.102843630 DT.120992816 DT.120992827

DT.92437991 DT.91990899

24/483 AceView cDNA sequences (see all 483 ):

BM829735 CB107753 CR623038 BU742430 AI281085 AW188309 CA436687 BU521193

BI762181 AA465647 BM791073 BI835845 AL541358 BM126985 AA055233 AI129437

N46821 BI962513 BM504599 BM762109 AI473299 AI076720 AA872392 BM476729

highest scoring ESTs for ID2:

D13891 AA151620 AA524819 AA526652 AA557557 AA594299 AA625292 AA946931 AI076720 AI087021

Unigene Cluster for ID2:

Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein

Hs.180919 [show with all ESTs]

Unigene Representative Sequence: CR623038

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000234091 ENST00000331129 ENST00000396290

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ID2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ID2

¹ / ² / ³

7 probe-sets matching ID2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41216_r_at²^{, 3}	U95-A	3	1.00	0.91	0.70	0.15	D13891	1.00	0.90	0.95	1
64354_f_at²^{, 3}	U95-C	2	1.00	0.72	0.99	1.04	AA557557	0.80	1.00	0.91	1
41215_s_at²^{, 3}	U95-A	2	1.00	0.50	0.99	0.96	D13891	1.00	0.90	0.95	1
201565_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002166	0.60	1.00	0.82	1
201566_x_at²^{, 3}	U133-A	2	1.00	0.91	--	--	D13891	1.00	0.90	0.95	1
201565_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201566_x_at²	U133Plus2	2	1.00	0.91	--	--	--	--	--	--	--

GeneDecks ID2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCTGAAGTCA

SOURCE GeneReport for Unigene cluster: Hs.180919
Expression variation in blood from EXPOLDB for ID2
UniProtKB/Swiss-Prot: ID2_HUMAN, Q02363
Tissue specificity: Highly expressed in early fetal tissues, including those of the central nervous
system

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ID2 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	ID2¹	--	inhibitor of DNA binding 2, dominant negative helix-loop-helix more	94.53(n) 98.51(a)	505025 NM_001034231.1 NP_001029403.1
rat (Rattus norvegicus)	Id2¹	--	inhibitor of DNA binding 2	94.03(n) 97.76(a)	25587 NM_013060.2 NP_037192.1
mouse (Mus musculus)	Id2^{1, 5}	12 (7.00 cM)⁵	inhibitor of DNA binding 2^{1, 5}	95.02(n)¹ 98.51(a)¹	15902¹ NM_010496.2¹ NP_034626.1¹ AF077860⁵ AF077861⁵ (see all 16)
chicken (Gallus gallus)	ID2¹	--	inhibitor of DNA binding 2, dominant negative helix-loop-helix more	86.32(n) 94.03(a)	395852 NM_205002.1 NP_990333.1
zebrafish (Danio rerio)	id2²	--	inhibitor of DNA binding 2, dominant negative helix-loop-helix more	78.85(n)	266599 AY398363.1

About this table Species with no ortholog for ID2

ENSEMBL Gene Tree for ID2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ID2 gene

ID1² ID3² ID4²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/41 NCBI SNPs in ID2 are shown (see all 41 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 21)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs11885600^1,2	A,C,F,H	8737851(+)	`GGTGCA/GTCCAA`	1	--	ng5¹		6		EU EA WA NA	600
	rs2241740^1,2	F,H	8738035(+)	`TGGGGC/AGCATA`	1	--	ng5¹		5		EA EU WA	1504
--	rs11898041^1,2	A,C	8742492(+)	`CCCGAA/GGGTTA`	1	--	ng3¹		0	--	--	--	--
--	rs11894184^1,2	A,C	8742462(+)	`TGATTC/TCAGGT`	1	--	ng3¹		0	--	--	--	--
	rs11904319^1,2	C,F	8739553(+)	`GCCACC/ATTCCG`	1	--	ng5¹		2		NA	182
	rs1317966^1,2	A	8737897(-)	`TTCCCC/TAGGCC`	1	--	ng5¹		1		MN	184
--	rs10182838^1,2	C	8742120(+)	`CCCCCA/CCACAC`	1	--	ng3¹		0	--	--	--	--
--	rs4899^1,2	C	8740064(+)	`ACCCTC/TAACAC`	1	L/L	syn¹		0	--	--	--	--
	rs2306067^1,2	C,F,H	8741004(+)	`GAAGCA/GGACTG`	1	--	int¹		9		EA EU WA	2338
--	rs3845751^1,2	A,C	8740363(+)	`aaaaaA/Caaaaa`	1	--	int¹ trp³		0	--	--	--	--

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HapMap Linkage Disequilibrium images for ID2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600386

10/15 Novoseek disease relationships for ID2 gene (see all 15 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	56.16	12	11034201 (2), 15831462 (1), 16733829 (1), 16549780 (1) (see all 9)
ewings sarcoma	43.86	10	16869242 (7), 12527902 (3)
tumors	36.59	38	12545167 (3), 16549780 (3), 12447693 (2), 18085637 (2) (see all 22)
lymphoma	12.84	7	15492249 (2), 18085637 (1), 8632670 (1)
cancer	10.15	7	12447693 (1), 16733829 (1), 9731481 (1), 18413820 (1) (see all 6)
colon carcinoma	5.41	5	11572874 (2), 16007183 (1)
glioma	1.03	2	7622574 (1), 12007145 (1)
primary tumor	0.00	1	12447693 (1)
hypertrophy	0.00	2	16002773 (1), 15601750 (1)
breast cancer	0.00	1	15489884 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/186 PubMed articles for ID2 gene (see all 186 ):

Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. (PubMed id 8294468)^{2, 3, 4} Hara E....Oda K. (1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A human Id-like helix-loop-helix protein expressed during early development. (PubMed id 1741406)^{3, 4} Biggs J.... Israel M.A. (1992)
Id2 promotes the invasive growth of MCF-7 and SKOV-3 cells by a novel mechanism independent of dimerization to basic helix-loop-helix factors. (PubMed id 19257909)^{1, 3} Meng Y....Han W. (2009)
Regulation of Id2 expression in EL4 T lymphoma cells overexpressing growth hormone. (PubMed id 19010462)^{1, 3} Weigent D.A. (2009)
The helix-loop-helix protein Id2 is expressed differentially and induced by myc in T-cell lymphomas. (PubMed id 18085637)^{1, 3} Cotta C.V....Rassidakis G.Z. (2008)
The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system. (PubMed id 16549780)^{1, 3} Lasorella A. and Iavarone A. (2006)
Induction of ID2 expression by hypoxia-inducible factor-1: a role in dedifferentiation of hypoxic neuroblastoma cells. (PubMed id 15252039)^{1, 3} Lofstedt T....Axelson H. (2004)
The Id2 gene is a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors. (PubMed id 12447693)^{1, 3} Nishimori H....Tokino T. (2002)
Id2 specifically alters regulation of the cell cycle by tumor suppressor proteins. (PubMed id 8649364)^{1, 3} Lasorella A....Israel M.A. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 3398	HGNC: 5361	AceView: ID2	Ensembl:ENSG00000115738	euGenes: HUgn3398
ECgene: ID2	H-InvDB: ID2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for ID2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ID2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ID2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ID2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ID2		Antibodies for ID2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ID2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ID2)
	Antibodies (ID2)
	Chimera RNAi (ID2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for ID2

	Recombinant Proteins (ID2)
	Antibodies (ID2)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for ID2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ID2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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ID2 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for ID2

Summaries
for ID2

Genomic Location
for ID2

Proteins
for ID2

Protein Domains/
Families
for ID2

Gene Function
for ID2

Pathways & Interactions
for ID2

Drugs & Compounds
for ID2

Transcripts
for ID2

Expression
for ID2

Orthologs
for ID2

Paralogs
for ID2

SNPs/Variants
for ID2

Disorders & Mutations
for ID2

Medical News
for ID2

Publications
for ID2

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Genome Databases showing ID2

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Specialized Databases showing ID2

Licensable Technologies
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ID2 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor ID2

Summariesfor ID2

Genomic Locationfor ID2

Proteinsfor ID2

Protein Domains/Familiesfor ID2

Gene Functionfor ID2

Pathways & Interactionsfor ID2

Drugs & Compoundsfor ID2

Transcriptsfor ID2

Expression for ID2

Orthologsfor ID2

Paralogsfor ID2

SNPs/Variantsfor ID2

Disorders & Mutationsfor ID2

Medical Newsfor ID2

Publicationsfor ID2

Search for ID2

Genome Databases showing ID2

Other Databases showing ID2

Specialized Databases showing ID2

Licensable Technologiesfor ID2

Servicesfor ID2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ID2

Summaries
for ID2

Genomic Location
for ID2

Proteins
for ID2

Protein Domains/
Families
for ID2

Gene Function
for ID2

Pathways & Interactions
for ID2

Drugs & Compounds
for ID2

Transcripts
for ID2

Expression
for ID2

Orthologs
for ID2

Paralogs
for ID2

SNPs/Variants
for ID2

Disorders & Mutations
for ID2

Medical News
for ID2

Publications
for ID2

Licensable Technologies
for ID2

Services
for ID2