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Aliases for ID1 Gene

Aliases for ID1 Gene

  • Inhibitor Of DNA Binding 1, HLH Protein 2 3
  • Inhibitor Of DNA Binding 1, Dominant Negative Helix-Loop-Helix Protein 2 3 5
  • Inhibitor Of Differentiation 1 2 3 4
  • Class B Basic Helix-Loop-Helix Protein 24 3 4
  • BHLHb24 3 4
  • ID 3 4
  • DJ857M17.1.2 (Inhibitor Of DNA Binding 1, Dominant Negative Helix-Loop-Helix Protein) 3
  • DNA-Binding Protein Inhibitor ID-1 2
  • Inhibitor Of DNA Binding 1 4

External Ids for ID1 Gene

Previous GeneCards Identifiers for ID1 Gene

  • GC20P029981
  • GC20P030891
  • GC20P030938
  • GC20P029656
  • GC20P030193
  • GC20P026981

Summaries for ID1 Gene

Entrez Gene Summary for ID1 Gene

  • The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ID1 Gene

ID1 (Inhibitor Of DNA Binding 1, HLH Protein) is a Protein Coding gene. Diseases associated with ID1 include Multicentric Castleman Disease and Chemical Colitis. Among its related pathways are TGF-beta signaling pathway (KEGG) and Id Signaling Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein dimerization activity. An important paralog of this gene is ID3.

UniProtKB/Swiss-Prot for ID1 Gene

  • Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).

Gene Wiki entry for ID1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ID1 Gene

Genomics for ID1 Gene

Regulatory Elements for ID1 Gene

Enhancers for ID1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ID1 on UCSC Golden Path with GeneCards custom track

Promoters for ID1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ID1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ID1 gene promoter:

Genomic Location for ID1 Gene

Chromosome:
20
Start:
31,605,283 bp from pter
End:
31,606,515 bp from pter
Size:
1,233 bases
Orientation:
Plus strand

Genomic View for ID1 Gene

Genes around ID1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ID1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ID1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ID1 Gene

Proteins for ID1 Gene

  • Protein details for ID1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41134-ID1_HUMAN
    Recommended name:
    DNA-binding protein inhibitor ID-1
    Protein Accession:
    P41134
    Secondary Accessions:
    • A8K537
    • E1P5L4
    • O00651
    • O00652
    • Q16371
    • Q16377
    • Q5TE66
    • Q5TE67
    • Q969Z7
    • Q9H0Z5
    • Q9H109

    Protein attributes for ID1 Gene

    Size:
    155 amino acids
    Molecular mass:
    16133 Da
    Quaternary structure:
    • Heterodimer with other HLH proteins. Interacts with COPS5, IFI204, GATA4 and NKX2-5 (By similarity). Interacts with CLOCK and ARNTL/BMAL1.

    Alternative splice isoforms for ID1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ID1 Gene

Proteomics data for ID1 Gene at MOPED

Post-translational modifications for ID1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ID1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for Id1

No data available for DME Specific Peptides for ID1 Gene

Domains & Families for ID1 Gene

Gene Families for ID1 Gene

Protein Domains for ID1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ID1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41134

UniProtKB/Swiss-Prot:

ID1_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with ID1: view

Function for ID1 Gene

Molecular function for ID1 Gene

GENATLAS Biochemistry:
inhibitor of DNA binding 1,putative transcription regulator,expressed during early development and in adult tissues,inhibiting transcription factors of the basic helix loop helix family,controlling growth and/or differentiation of several cell types,potentially required for neurogenesis and angiogenesis
UniProtKB/Swiss-Prot Function:
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).

Gene Ontology (GO) - Molecular Function for ID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15694377
GO:0046983 protein dimerization activity IEA --
GO:0047485 protein N-terminus binding IEA --
genes like me logo Genes that share ontologies with ID1: view
genes like me logo Genes that share phenotypes with ID1: view

Animal Models for ID1 Gene

MGI Knock Outs for ID1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ID1 Gene

Localization for ID1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ID1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ID1 Gene COMPARTMENTS Subcellular localization image for ID1 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
cytoskeleton 3
plasma membrane 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for ID1 Gene

Pathways & Interactions for ID1 Gene

genes like me logo Genes that share pathways with ID1: view

Gene Ontology (GO) - Biological Process for ID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001525 angiogenesis TAS 14522471
GO:0007179 transforming growth factor beta receptor signaling pathway TAS 14522471
GO:0007507 heart development IEA --
GO:0007623 circadian rhythm IEA --
genes like me logo Genes that share ontologies with ID1: view

No data available for SIGNOR curated interactions for ID1 Gene

Drugs & Compounds for ID1 Gene

(2) Drugs for ID1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for ID1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ID1: view

Transcripts for ID1 Gene

mRNA/cDNA for ID1 Gene

Unigene Clusters for ID1 Gene

Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ID1 Gene

No ASD Table

Relevant External Links for ID1 Gene

GeneLoc Exon Structure for
ID1
ECgene alternative splicing isoforms for
ID1

Expression for ID1 Gene

mRNA expression in normal human tissues for ID1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ID1 Gene

This gene is overexpressed in Bladder (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ID1 Gene



SOURCE GeneReport for Unigene cluster for ID1 Gene Hs.504609

genes like me logo Genes that share expression patterns with ID1: view

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ID1 Gene

Orthologs for ID1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ID1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ID1 35
  • 90.31 (n)
  • 91.49 (a)
ID1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ID1 35
  • 93.38 (n)
  • 95.04 (a)
mouse
(Mus musculus)
Mammalia Id1 35
  • 89.38 (n)
  • 94.81 (a)
Id1 16
Id1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ID1 35
  • 99.14 (n)
  • 100 (a)
ID1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Id1 35
  • 88.15 (n)
  • 94.07 (a)
oppossum
(Monodelphis domestica)
Mammalia ID1 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves ID1 35
  • 68.13 (n)
  • 64.84 (a)
zebrafish
(Danio rerio)
Actinopterygii id1 35
  • 66.94 (n)
  • 63.11 (a)
id1 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta emc 36
  • 18 (a)
OneToMany
Species with no ortholog for ID1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ID1 Gene

ENSEMBL:
Gene Tree for ID1 (if available)
TreeFam:
Gene Tree for ID1 (if available)

Paralogs for ID1 Gene

Paralogs for ID1 Gene

(3) SIMAP similar genes for ID1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ID1: view

Variants for ID1 Gene

Sequence variations from dbSNP and Humsavar for ID1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_049544 -
rs6119574 -- 31,603,607(+) AGGCT(G/T)GAGTG upstream-variant-2KB
rs6119575 -- 31,603,684(+) CTCCC(C/G)AGTAG upstream-variant-2KB
rs60794663 -- 31,603,578(+) TTTTT(-/TTTT)GAGAC upstream-variant-2KB
rs73613713 -- 31,603,452(+) CACCA(C/T)GTTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ID1 Gene

Variant ID Type Subtype PubMed ID
nsv470546 CNV Gain 18288195
nsv458961 CNV Gain 19166990

Variation tolerance for ID1 Gene

Residual Variation Intolerance Score: 79.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 46.98% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ID1 Gene

Disorders for ID1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ID1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
multicentric castleman disease
  • macular dystrophy, corneal type 1
chemical colitis
- elite association - COSMIC cancer census association via MalaCards
Search ID1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ID1

Genetic Association Database (GAD)
ID1
Human Genome Epidemiology (HuGE) Navigator
ID1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ID1
genes like me logo Genes that share disorders with ID1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ID1 Gene

Publications for ID1 Gene

  1. Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. (PMID: 8294468) Hara E. … Oda K. (J. Biol. Chem. 1994) 2 3 4 67
  2. Id1, inhibitor of differentiation, is a key protein mediating anti-tumor responses of gamma-tocotrienol in breast cancer cells. (PMID: 19926394) Yap W.N. … Yap Y.L. (Cancer Lett. 2010) 3 23
  3. Elevated endogenous expression of the dominant negative basic helix-loop-helix protein ID1 correlates with significant centrosome abnormalities in human tumor cells. (PMID: 20070914) Manthey C. … Hasskarl J. (BMC Cell Biol. 2010) 3 23
  4. Inhibitor of differentiation 1 (ID1) promotes cell survival and proliferation of prostate epithelial cells. (PMID: 20186495) Schmidt M. … Chaudhary J. (Cell. Mol. Biol. Lett. 2010) 3 23
  5. ID1 enhances docetaxel cytotoxicity in prostate cancer cells through inhibition of p21. (PMID: 20388787) Geng H. … Qian D.Z. (Cancer Res. 2010) 3 23

Products for ID1 Gene

  • Addgene plasmids for ID1

Sources for ID1 Gene

Content