Aliases for ID1 Gene
- Inhibitor Of DNA Binding 1, Dominant Negative Helix-Loop-Helix Protein 2 3
- Class B Basic Helix-Loop-Helix Protein 24 3 4
- Inhibitor Of Differentiation 1 3 4
- BHLHb24 3 4
- ID 3 4
- DJ857M17.1.2 (Inhibitor Of DNA Binding 1, Dominant Negative Helix-Loop-Helix Protein) 3
- DNA-Binding Protein Inhibitor ID-1 2
- Inhibitor Of DNA Binding 1 4
External Ids for ID1 Gene
Previous GeneCards Identifiers for ID1 Gene
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ID1 Gene
ID1 (Inhibitor Of DNA Binding 1, Dominant Negative Helix-Loop-Helix Protein) is a Protein Coding gene. Diseases associated with ID1 include multicentric castleman disease. Among its related pathways are Ras signaling pathway and Signaling pathways regulating pluripotency of stem cells. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein dimerization activity. An important paralog of this gene is ID3.
UniProtKB/Swiss-Prot for ID1 Gene
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity).