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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ID1 Gene

protein-coding GIFtS: 59
GCID: GC20P030193

inhibitor of DNA binding 1, dominant negative helix-loop-helix...

Explore 57 diseases affiliated with
ID1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Inhibitor Of DNA Binding 1, Dominant Negative Helix-Loop-Helix Protein¹ ²		DJ857M17.1.2 (Inhibitor Of DNA Binding 1, Dominant Negative Helix-Loop-Helix Protein)²
BHLHb24¹		DNA-Binding Protein Inhibitor ID-1²
Class B Basic Helix-Loop-Helix Protein 24² ³		Inhibitor Of Differentiation 1²
ID² ³		BHLHB24³
DJ857M17.1.2¹		Inhibitor Of DNA Binding 1³

External Ids:	HGNC: 5360¹	Entrez Gene: 3397²	Ensembl: ENSG00000125968⁷	OMIM: 600349⁵	UniProtKB: P41134³

Export aliases for ID1 gene to outside databases

Previous GC identifers: GC20P029981 GC20P030891 GC20P030938 GC20P029656 GC20P026981

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ID1:

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the

basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit

the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may

play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have

been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ID1_HUMAN, P41134

Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers

with other HLH proteins, thereby inhibiting DNA binding

Gene Wiki entry for ID1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011362.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ID1 gene promoter:
Nkx2-5
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ID1 promoter sequence

Search SABiosciences Chromatin IP Primers for ID1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ID1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11 Ensembl cytogenetic band: 20q11.21 HGNC cytogenetic band: 20q11

ID1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ID1 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P030193: view genomic region (about GC identifiers)

Start:	30,193,086 bp from pter	End:	30,194,318 bp from pter
Size:	1,233 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ID1_HUMAN, P41134 (See protein sequence)

Recommended Name: DNA-binding protein inhibitor ID-1

Size: 155 amino acids; 16133 Da

Subunit: Heterodimer with other HLH proteins. Interacts with COPS5 (By similarity)

Subcellular location: Cytoplasm (By similarity). Nucleus

Developmental stage: Expression correlates with proliferation in some types of cells

Secondary accessions: A8K537 E1P5L4 O00651 O00652 Q16371 Q16377 Q5TE66 Q5TE67 Q969Z7 Q9H0Z5 Q9H109

Alternative splicing: 2 isoforms: P41134-1 P41134-2

Explore the universe of human proteins at neXtProt for ID1: NX_P41134

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P41134

ID1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_002156.2 NP_851998.1

ENSEMBL proteins:

ENSP00000365280 ENSP00000365273

Human Recombinant Protein Products for ID1:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	OriGene Purified Protein: ID1 OriGene Protein Over-expression Lysate (see all 3): ID1 OriGene Custom Protein Services for ID1
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	Novus Biologicals ID1 Protein Novus Biologicals ID1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ID1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	--	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

ID1 for ontologies About GeneDecksing

ID1 Antibody Products:

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	Novus Biologicals ID1 Antibodies
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	Uscn Antibodies for ID1
	Search ThermoFisher Antibodies for ID1

Assay Products for ID1:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for ID1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ID1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ID1 for domains About GeneDecksing

2 InterPro domains/families:

IPR026052 DNA-bd_prot-inh

IPR011598 HLH_dom

Graphical View of Domain Structure for InterPro Entry P41134

ProtoNet protein and cluster: P41134

UniProtKB/Swiss-Prot: ID1_HUMAN, P41134

Similarity: Contains 1 bHLH (basic helix-loop-helix) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ID1_HUMAN, P41134

Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers

with other HLH proteins, thereby inhibiting DNA binding

Genatlas biochemistry entry for ID1:

inhibitor of DNA binding 1,putative transcription regulator,expressed during early development and in adult

tissues,inhibiting transcription factors of the basic helix loop helix family,controlling growth and/or

differentiation of several cell types,potentially required for neurogenesis and angiogenesis

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0005515	protein binding	IPI	17855368
GO:0046983	protein dimerization activity	IEA	--

ID1 for ontologies About GeneDecksing

Phenotypes:
15/19 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Id1) (see all 19):

cardiovascular system	cellular	digestive/alimentary	embryogenesis	endocrine/exocrine gland
growth/size	hematopoietic system	immune system	liver/biliary system	mortality/aging
muscle	nervous system	no phenotypic analysis	renal/urinary system	reproductive system

ID1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Id1^tm1Zhu for ID1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ID1

miRNA Products:		miRTarBase miRNAs that target ID1: hsa-mir-100 (MIRT003418), hsa-mir-520h (MIRT004739)

		OriGene 3'-UTR Clone (see all 2): ID1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ID1
		8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate ID1 (see all 21):
		hsa-miR-495 hsa-miR-3200-5p hsa-miR-607 hsa-miR-16-2* hsa-miR-300 hsa-miR-4251 hsa-miR-330-5p hsa-miR-7-1*

		SwitchGear 3'UTR luciferase reporter plasmid: ID1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ID1 (see all 7) OriGene shRNA RFP: ID1 OriGene siRNA: ID1
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		Sirion Biotech Custom design and validation of potent shRNA sequences against ID1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ID1
			Sirion Biotech Customized adenovirus for overexpression of ID1 Sirion Biotech Customized adenovirus for potent knockdown of ID1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ID1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ID1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ID1 (NM_017551)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ID1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ID1
		Search LifeMap BioReagents cell lines for ID1
		Sirion Biotech Customized stable knockdown cell line services for ID1 Sirion Biotech Customized inducible knockdown cell line services for ID1 Sirion Biotech Customized stable overexpressing cell line services for ID1 Sirion Biotech Customized inducible overexpressing cell line services for ID1

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ID1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune response_IL-2 activation and signaling pathway

Immune response IL-3 activation and signaling pathway

0.41

Immune response_IL-3 activation and signaling pathway

0.41

Selected targets of C/EBPalpha

Selected targets of C/EBPalpha

1.00

Selected targets of CREB1

Selected targets of CREB1

1.00

Neural Crest Differentiation

Neural Crest Differentiation

1.00

IL-3 Signaling Pathway

IL-3 Signaling Pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

4 EMD Millipore Pathways for ID1

	Selected targets of CREB1
	Immune response IL-3 activation and signaling pathway
	Selected targets of C/EBPalpha
	Selected targets of p53

1 GeneGo (Thomson Reuters) Pathway for ID1

Immune response IL-3 activation and signaling pathway

5 BioSystems Pathways for ID1

	Neural Crest Differentiation
	IL-3 Signaling Pathway
	Id Signaling Pathway
	Notch-mediated HES/HEY network
	ALK1 signaling events

1 Kegg Pathway (Kegg details for ID1):

TGF-beta signaling pathway

ID1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ID1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/33 Interacting proteins for ID1 (P41134^{1, 3} ENSP00000365280⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 33)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CASK	O14936¹^,³, ENSP00000367408⁴	EBI-1215527,EBI-1215506 I2D: score=6 STRING: ENSP00000367408
CAV1	Q03135¹^,³, ENSP00000339191⁴	EBI-1215527,EBI-603614 I2D: score=1 STRING: ENSP00000339191
TCF3	P15923³, ENSP00000262965⁴	I2D: score=6 STRING: ENSP00000262965
MYF6	P23409³, ENSP00000228641⁴	I2D: score=3 STRING: ENSP00000228641
PSMD4	P55036³, ENSP00000357879⁴	I2D: score=3 STRING: ENSP00000357879

About this table

Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0001525	angiogenesis	TAS	14522471
GO:0001886	endothelial cell morphogenesis	IEA	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006915	apoptotic process	IEA	--

ID1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ID1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ID1
7 Novoseek chemical compound relationships for ID1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
matrigel	33.5	3	17412691 (2)
oligonucleotide	20.9	2	15489884 (1), 12406909 (1)
dbc-amp	16.8	2	16878319 (1), 17412691 (1)
vegf	6.42	8	15370294 (2), 15494533 (2), 17785115 (2)
oxygen	0	2	9748268 (1), 16840720 (1)
zinc	0	5	16784536 (2), 17928372 (1), 17307745 (1)
tyrosine	0	6	18559972 (2), 17418011 (1), 19643984 (1), 18381431 (1) (see all 5)

Search CenterWatch for drugs/clinical trials and news about ID1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ID1 gene (2 alternative transcripts):

NM_002165.3 NM_181353.2

Unigene Cluster for ID1:

Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

Hs.504609 [show with all ESTs]

Unigene Representative Sequence: BG165657

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000376112(uc002wwg.2) ENST00000376105(uc002wwh.2)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ID1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ID1
		8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate ID1 (see all 21):
		hsa-miR-495 hsa-miR-3200-5p hsa-miR-607 hsa-miR-16-2* hsa-miR-300 hsa-miR-4251 hsa-miR-330-5p hsa-miR-7-1*

		SwitchGear 3'UTR luciferase reporter plasmid: ID1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ID1 (see all 7) OriGene shRNA RFP: ID1 OriGene siRNA: ID1
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		Sirion Biotech Custom design and validation of potent shRNA sequences against ID1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ID1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ID1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ID1 (NM_017551)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ID1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ID1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ID1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ID1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ID1

Additional cDNA sequence:

AK291152.1 AK313786.1 BC000613.2 BC012420.1 BT007443.1 D13889.1 D13890.1 S78825.1

S78986.1 X77956.1

11 DOTS entries:

DT.449322 DT.100674315 DT.95360225 DT.100674312 DT.100852491 DT.92026432 DT.100674319 DT.100858114

DT.120828837 DT.91767771 DT.95360242

24/765 AceView cDNA sequences (see all 765):

BU631785 BQ083666 AI693174 BI768231 BM822678 BM767490 AI419619 BM849251

CB163037 CB150020 BQ695279 BM737973 BM787215 BM711233 CB147499 CB142043

BM840893 AI245062 BQ222774 BM970822 AI187108 CR610338 AI567364 BQ940719

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ID1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGTTCCTGCG

About this image

ID1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Extraembryonic Mesoderm

Extraembryonic Mural Cells

Extraembryonic Tissues

Lateral Plate Mesoderm

Splanchnic Mesoderm

Mural Cells

Pericytes, Smooth Muscle

Limb

Limb Bud

Limb Bud Mesenchyme Cells

Mesoderm

Kidney

Reproductive System

Umbilical Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/14 LifeMap Cells (see all 14)

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Adult human kidney epithelial cells (Primary Cell)

Kidney

Endoderm progenitor-like cells (Generation and expan...)

Endothelial progenitor cells (Derivation and purif...)

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

HyStem+BMP4-induced SK11 cells (HyStem+BMP4 inductio...)

Bone, Cartilage

HyStem+BMP4-induced SM30 cells (HyStem+BMP4 inductio...)

Adipose, Bone, Cartilage

See ID1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ID1

SOURCE GeneReport for Unigene cluster: Hs.504609

SABiosciences Expression via Pathway-Focused PCR Arrays including ID1 (see all 10):

TGFB/BMP Signaling Pathway in human mouse rat

Angiogenesis in human mouse rat

Notch Signaling Pathway in human mouse rat

Notch Signaling Targets in human mouse rat

Breast Cancer in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ID1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ID1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ID1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ID1

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for ID1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ID1 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Id1^{1 , 5}	inhibitor of DNA binding 1^{1, 5}	88.96(n)¹ 94.59(a)¹	2 (75.41 cM)⁵ 15901¹ NM_010495.2¹ NP_034625.1¹ 152736251⁵
chicken (Gallus gallus)	Aves	ID1¹	inhibitor of DNA binding 1, dominant negative helix-loop-helix more	65.82(n) 60.17(a)	395282 NM_204590.1 NP_989921.1
zebrafish (Danio rerio)	Actinopterygii	id1¹	inhibitor of DNA binding 1	66.94(n) 63.41(a)	30493 NM_131245.1 NP_571320.1

ENSEMBL Gene Tree for ID1 (if available)
TreeFam Gene Tree for ID1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ID1 gene

ID3² ID2² ID4²

3 SIMAP similar genes for ID1 using alignment to 1 protein entry: ID1_HUMAN:

ID2 ID3 ID4

ID1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6119574^1,2	C,A	--	26980105(+)	`AGGCTG/TGAGTG`	2	--	us2k¹		2	NA WA	4
rs6119575^1,2	C	--	26980182(+)	`CTCCCG/CAGTAG`	2	--	us2k¹		1	NA	2
rs62204643^1,2	C	--	26980490(+)	`ATTAAA/GTATTA`	2	--	us2k¹		2	NA	122
rs79095298^1,2	F	--	26980604(+)	`GAGGTG/AGGGGG`	2	--	us2k¹		1	NA	120
rs11905777^1,2	C,F,A,H	--	26980788(+)	`GCTAGC/ACCAGT`	2	--	us2k¹		10	NA WA CSA	252
rs6058189^1,2	C,F,A,H	--	26981084(+)	`CAAGGA/GGCTGC`	2	--	us2k¹ tfbs³		18	NS EA NA WA CSA	1889
rs114675099^1,2	C,F	--	26981107(+)	`GAATCG/AAATGC`	2	--	us2k¹		1	WA	118
rs59235640^1,2	C	--	26981139(+)	`ATCTAG/CTTCAC`	2	--	us2k¹		1	WA	2
rs73235781^1,2	C	--	26981154(+)	`CAGCCG/ACCCAG`	2	--	us2k¹		1	WA	2
rs6060260^1,2	C,F,A,H	--	26981602(+)	`CCACCC/TTTGCT`	2	--	us2k¹		17	NS EA NA WA	2052

HapMap Linkage Disequilibrium report for ID1 (30193086 - 30194318 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ID1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ID1 for disorders           About GeneDecksing

OMIM gene information: 600349    OMIM disorders: --

20/57 diseases for ID1 (see all 57):    About MalaCards

primitive neuroectodermal tumor otitis media squamous cell carcinoma neuroectodermal tumors

adenoid cystic carcinoma oral squamous cell carcinoma esophageal squamous cell carcinoma acute promyelocytic leukemia

rhabdoid tumors basal cell carcinoma acute myeloid leukemia rett syndrome

myeloid leukemia kaposi's sarcoma adenoiditis endometrial carcinoma

hepatitis b chondrosarcoma carcinoma pulmonary fibrosis

1 disease from the University of Copenhagen DISEASES database for ID1:

Prostate cancer

10/16 Novoseek disease relationships for ID1 gene (see all 16) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	30.4	64	20414347 (6), 17108123 (6), 18752043 (3), 17565736 (2) (see all 25)
neovascularization	25	3	16267257 (1), 15494533 (1), 16136355 (1)
erythroleukemia	16.3	2	7629100 (2)
cancer	14.9	24	20235117 (3), 18381431 (2), 14755252 (2), 9070860 (1) (see all 9)
prostate cancer	14.2	12	18752043 (4), 20388787 (3), 20186495 (2), 17108123 (2)
chondrosarcoma	12.7	4	16273214 (2), 9821964 (1)
melanoma	8.58	39	11507043 (6), 17565736 (5), 18240291 (4), 16189525 (4) (see all 6)
metastasis	7.29	12	19491902 (4), 19801974 (2), 20388805 (1), 15342397 (1) (see all 6)
metastatic melanoma	7.17	2	15596294 (1), 11507043 (1)
breast cancer	6.2	14	18048329 (2), 19217708 (2), 19801974 (2), 18413773 (2) (see all 7)

Human Genome Epidemiology (HuGE) Navigator: ID1 (3 documents)

Export disorders for ID1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ID1 gene, integrated from 9 sources (see all 318):
(articles sorted by number of sources associating them with ID1)

Utopia: connect your pdf to the dynamic
world of online information

Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. (PubMed id 8294468)^{1, 2, 3} Hara E....Oda K. (1994)
Genomic organization, sequence, and chromosomal localization of the human helix-loop-helix Id1 gene. (PubMed id 9070860)^{1, 2, 9} Nehlin J.O.... Campisi J. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
Id gene expression during development and molecular cloning of the human Id-1 gene. (PubMed id 7637581)^{1, 2} Zhu W.... Israel M.A. (1995)
Nucleotide sequence of the cDNA encoding human helix-loop-helix Id-1 protein: identification of functionally conserved residues common to Id proteins. (PubMed id 8086456)^{1, 2} Deed R.W.... Norton J.D. (1994)
ID1, inhibitor of differentiation/DNA binding, is an effector of the p53-dependent DNA damage response pathway. (PubMed id 18556654)^{1, 9} Qian Y. and Chen X. (2008)
Id1 gene expression is up-regulated in hyperplastic and neoplastic thyroid tissue and regulates growth and differentiation in thyroid cancer cells. (PubMed id 15579766)^{1, 9} Kebebew E....Miner R. (2004)
ID1 enhances docetaxel cytotoxicity in prostate cance r cells through inhibition of p21. (PubMed id 20388787)^{1, 9} Geng H....Qian D.Z. (2010)
Strong expression of ID1 protein is associated with decreased survival, increased expression of ephrin-A1/EPHA2, and reduced thrombospondin-1 in malignant melanoma. (PubMed id 16189525)^{1, 9} Straume O. and Akslen L.A. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3397	HGNC: 5360	AceView: ID1	Ensembl:ENSG00000125968	euGenes: HUgn3397
ECgene: ID1	Kegg: 3397	H-InvDB: ID1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ID1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ID1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ID1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ID1 gene:
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GeneCards and IP:
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