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ID1 Gene

protein-coding GIFtS: 60

GC20P029656

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ID ^², ³
OTTHUMP00000030534 ^²
OTTHUMP00000030535 ^²
bHLHb24 ^¹, ²
dJ857M17.1.2 ^¹

Descriptions
DNA-binding protein inhibitor ID-1 ^²
Inhibitor of DNA binding 1 ^², ³
dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein) ^²
inhibitor of DNA binding 1, dominant negative helix-loop-helix protein ^²
inhibitor of differentiation 1 ^²

External Ids
HGNC: 5360¹
Entrez Gene: 3397²
UniProtKB: P41134³
Ensembl: ENSG00000125968⁷

Search outside databases for aliases for ID1 gene

Previous GC identifers: GC20P029981 GC20P030891 GC20P030938

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for ID1:

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers

with members of the basic HLH family of transcription factors. The encoded protein has no DNA

binding activity and therefore can inhibit the DNA binding and transcriptional activation ability

of basic HLH proteins with which it interacts. This protein may play a role in cell growth,

senescence, and differentiation. Two transcript variants encoding different isoforms have been

found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: ID1_HUMAN, P41134

Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able

to form heterodimers with other HLH proteins, thereby inhibiting DNA binding

Gene Wiki entry for ID1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ID1 gene

Entrez Gene cytogenetic band: 20q11 Ensembl cytogenetic band: 20q11.21 HGNC cytogenetic band: 20q11

ID1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P029656: (about GC identifiers)

Start:	29,656,753 bp from pter
End:	29,657,974 bp from pter
Size:	1,222 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000020.9 NT_028392.5

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ID1_HUMAN, P41134 (See protein sequence)

Recommended Name: DNA-binding protein inhibitor ID-1

Size: 155 amino acids; 16133 Da

Subunit: Heterodimer with other HLH proteins. Interacts with COPS5 (By similarity)

Subcellular location: Nucleus

Developmental stage: Expression correlates with proliferation in some types of cells

Secondary accessions: O00651 O00652 Q16371 Q16377 Q5TE66 Q5TE67 Q969Z7 Q9H0Z5 Q9H109

Alternative splicing: 2 isoforms: P41134-1 P41134-2 (Additional isoforms seem to exist)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_002156.2 NP_851998.1

ENSEMBL proteins:

ENSP00000365273 ENSP00000365280

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Id1)
	Human Recombinant Proteins from Abnova (ID1)

OriGene Purified Recombinant Human Protein: ID1

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

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Antibodies for ID1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ID1
	Sigma-Aldrich Antibodies for ID1
	R&D Systems Antibodies for ID1
	Antibodies from Abcam (Id1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ID1)
	Novus Biologicals Antibodies for ID1

Assays for ID1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P41134

ProtoNet protein and cluster: P41134

UniProtKB/Swiss-Prot: ID1_HUMAN, P41134

Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ID1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ID1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_181353

Applied Biosystems Silencer® siRNAs for ID1

Sigma-Aldrich siRNA for ID1

Sigma-Aldrich shRNA for ID1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ID1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002165
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002165
untagged cDNA clones in CMV expression vector (see all 3): NM_002165

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002165

UniProtKB/Swiss-Prot: ID1_HUMAN, P41134

Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able

to form heterodimers with other HLH proteins, thereby inhibiting DNA binding

Genatlas biochemistry entry for ID1:

inhibitor of DNA binding 1,putative transcription regulator,expressed during early development and

in adult tissues,inhibiting transcription factors of the basic helix loop helix family,controlling

growth and/or differentiation of several cell types,potentially required for neurogenesis and

angiogenesis

11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Id1):

	embryogenesis	growth/size	hematopoietic system	immune system
lethality-postnatal	lethality-prenatal/perinatal	nervous system	normal	respiratory system
tumorigenesis

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	15138269 15694377 17855368 17891176
GO:0016564	transcription repressor activity	IDA	15138269

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for ID1

5/50 Interacting proteins for ID1 (P41134¹ ENSP00000365280³) via UniProtKB, MINT, and/or STRING (see all 50 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PSMD4	P55036¹, ENSP00000357876³	EBI-1215527, EBI-359318 STRING (score=.978)
CAV1	Q03135¹, ENSP00000339191³	EBI-1215527, EBI-603614 STRING (score=.921)
CASK	O14936¹, ENSP00000367405³	EBI-1215527, EBI-1215506 STRING (score=.724)
MYOD1	ENSP00000250003³	STRING (score=.998)
TCF3	ENSP00000262965³	STRING (score=.992)

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5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0007275	multicellular organismal development	IEA	--
GO:0007507	heart development	IEA	--
GO:0010621	negative regulation of transcription by transcription factor localization	TAS	14522471
GO:0016481	negative regulation of transcription	IDA	15138269

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ID1
6 Novoseek chemical compound relationships for ID1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
matrigel	31.49	3	17412691 (2)
oligonucleotide	25.16	2	15489884 (1), 12406909 (1)
dbc-amp	20.39	2	16878319 (1), 17412691 (1)
oxygen	0.00	2	9748268 (1), 16840720 (1)
zinc	0.00	5	16784536 (2), 17928372 (1), 17307745 (1)
tyrosine	0.00	5	18559972 (2), 17418011 (1), 18381431 (1), 8284227 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ID1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ID1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_181353

Sigma-Aldrich siRNA for ID1

Sigma-Aldrich shRNA for ID1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002165 NM_181353

REFSEQ mRNAs for ID1 gene (2 alternative transcripts):

NM_002165.2 NM_181353.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002165 NM_181353

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002165
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002165
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_002165

Additional cDNA sequence:

AK291152.1 AK313786.1 BC000613.2 BC012420.1 BT007443.1 CR591965.1 CR592689.1 CR593062.1

CR599901.1 CR600217.1 CR610338.1 CR615862.1 CR621997.1 CR626444.1 D13889.1 D13890.1

S78825.1 S78986.1 X77956.1

11 DOTS entries:

DT.449322 DT.100674315 DT.95360225 DT.100674312 DT.100852491 DT.92026432 DT.100674319 DT.100858114

DT.120828837 DT.91767771 DT.95360242

24/765 AceView cDNA sequences (see all 765 ):

AI453028 AW297817 BQ695339 CB147499 BU727679 CB128281 AI419619 AI245062

BM918524 CR593062 CB144504 BQ219146 AU103028 BM825371 BU625831 CR592689

CB142361 AL546878 BE387715 NM_181353 BF194895 CB163037 BM755794 BQ045281

highest scoring ESTs for ID1:

AW009814 S78825 X77956 AA029307 AA039846 AA098812 AA100975 AA158021 AA219438 AA293531

Unigene Cluster for ID1:

Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

Hs.504609 [show with all ESTs]

Unigene Representative Sequence: BG165657

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000376105 ENST00000376112

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ID1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ID1

¹ / ² / ³

6 probe-sets matching ID1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36619_r_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.75	S78825	1.00	1.00	1.00	1
36618_g_at²^{, 3}	U95-A	1	1.00	1.00	1.00	0.90	X77956	1.00	1.00	1.00	1
36617_at²^{, 3}	U95-A	1	1.00	1.00	0.97	1.19	X77956	1.00	1.00	1.00	1
74752_at²^{, 3}	U95-D	1	0.88	1.00	0.97	1.16	AW009814	1.00	1.00	1.00	1
208937_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	D13889	0.80	1.00	0.91	1
208937_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ID1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CGTTCCTGCG

SOURCE GeneReport for Unigene cluster: Hs.504609
Expression variation in blood from EXPOLDB for ID1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ID1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ID1¹	--	inhibitor of DNA binding 1, dominant negative helix-loop-helix more	93.07(n) 94.81(a)	609779 XM_847117.1 XP_852210.1
chimpanzee (Pan troglodytes)	ID1¹	--	inhibitor of DNA binding 1, dominant negative helix-loop-helix more	98.92(n) 100(a)	469912 XM_001152873.1 XP_001152873.1
cow (Bos taurus)	ID1¹	--	inhibitor of DNA binding 1, dominant negative helix-loop-helix more	90.26(n) 91.56(a)	497011 XM_585780.3 XP_585780.2
rat (Rattus norvegicus)	Id1¹	--	inhibitor of DNA binding 1	87.61(n) 92.57(a)	25261 NM_012797.2 NP_036929.2
mouse (Mus musculus)	Id1^{1, 5}	2 (84.00 cM)⁵	inhibitor of DNA binding 1^{1, 5}	88.96(n)¹ 94.59(a)¹	15901¹ NM_010495.2¹ NP_034625.1¹ AA407767⁵ AB221668⁵ (see all 15)

About this table Species with no ortholog for ID1

ENSEMBL Gene Tree for ID1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ID1 gene

ID2² ID3² ID4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/37 NCBI SNPs in ID1 are shown (see all 37 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 24)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs6060262^1,2	A,C,F,H	29656732(+)	`AAGACA/CAGCTG`	2	--	ng5¹		4		EU EA WA	412
--	rs6060261^1,2	A,C,F,H	29656609(+)	`GCGAGC/GAGGCA`	2	--	ng5¹		4		EU EA WA	406
	rs6058189^1,2	A,C,F,H	29656050(+)	`CAAGGA/GGCTGC`	2	--	ng5¹ tfbs³		4		EU EA WA	412
--	rs6060260^1,2	A,C,F,H	29656568(+)	`CCACCC/TTTGCT`	2	--	ng5¹		4		EU EA WA	412
--	rs2811^1,2	A,C,F	29657909(+)	`ACTGAA/GAATAT`	2	--	ut3¹		2		MN	368
--	rs8116155^1,2	A,C	29657615(+)	`ATTACC/GTGCTC`	2	--	ut3¹ ese³		0	--	--	--	--
	rs6060272^1,2	H	29658387(+)	`GGAAAG/AGGACT`	2	--	ng3¹		1		WA	120
	rs6060263^1,2	A	29656771(+)	`AACTGC/TTCCAT`	2	--	ut5¹		0	--	--	--	--
--	rs6058196^1,2	A	29658375(+)	`GTGAGA/TCCCAG`	2	--	ng3¹		0	--	--	--	--
--	rs6119574^1,2	A	29655071(+)	`AGGCTG/TGAGTG`	2	--	ng5¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for ID1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600349

10/16 Novoseek disease relationships for ID1 gene (see all 16 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
neovascularization	29.86	3	16267257 (1), 15494533 (1), 16136355 (1)
tumors	27.66	49	17108123 (6), 18752043 (3), 17565736 (2), 11507043 (2) (see all 19)
erythroleukemia	20.02	2	7629100 (2)
chondrosarcoma	17.17	4	16273214 (2), 9821964 (1)
melanoma	13.72	39	11507043 (6), 17565736 (5), 18240291 (4), 16189525 (4) (see all 6)
metastatic melanoma	12.02	2	15596294 (1), 11507043 (1)
prostate cancer	11.15	7	18752043 (4), 17108123 (2)
cancer	8.17	18	18381431 (2), 14755252 (2), 9070860 (1), 17108123 (1) (see all 6)
endometrial carcinoma	7.44	5	11275368 (4)
thyroid cancer	5.45	8	15579766 (4), 16029118 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/226 PubMed articles for ID1 gene (see all 226 ):

Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. (PubMed id 8294468)^{2, 3, 4} Hara E....Oda K. (1994)
Genomic organization, sequence, and chromosomal localization of the human helix-loop-helix Id1 gene. (PubMed id 9070860)^{1, 3, 4} Nehlin J.O.... Campisi J. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{3, 4} Deloukas P....Rogers J. (2001)
Id gene expression during development and molecular cloning of the human Id-1 gene. (PubMed id 7637581)^{3, 4} Zhu W.... Israel M.A. (1995)
Nucleotide sequence of the cDNA encoding human helix-loop-helix Id-1 protein: identification of functionally conserved residues common to Id proteins. (PubMed id 8086456)^{3, 4} Deed R.W.... Norton J.D. (1994)
ID1, inhibitor of differentiation/DNA binding, is an effector of the p53-dependent DNA damage response pathway. (PubMed id 18556654)^{1, 3} Qian Y. and Chen X. (2008)
Id1 gene expression is up-regulated in hyperplastic and neoplastic thyroid tissue and regulates growth and differentiation in thyroid cancer cells. (PubMed id 15579766)^{1, 3} Kebebew E....Miner R. (2004)
Strong expression of ID1 protein is associated with decreased survival, increased expression of ephrin-A1/EPHA2, and reduced thrombospondin-1 in malignant melanoma. (PubMed id 16189525)^{1, 3} Straume O. and Akslen L.A. (2005)
The helix-loop-helix transcription factor Id1 is highly expressed in psoriatic involved skin. (PubMed id 14690332)^{1, 3} Bjorntorp E....Lindahl A. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 3397	HGNC: 5360	AceView: ID1	Ensembl:ENSG00000125968	euGenes: HUgn3397
ECgene: ID1	H-InvDB: ID1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ID1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ID1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ID1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ID1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ID1		Antibodies for ID1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ID1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ID1)
	Antibodies (ID1)
	Chimera RNAi (ID1)
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	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for ID1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ID1

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ID1 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for ID1

Summaries
for ID1

Genomic Location
for ID1

Proteins
for ID1

Protein Domains/
Families
for ID1

Gene Function
for ID1

Pathways & Interactions
for ID1

Drugs & Compounds
for ID1

Transcripts
for ID1

Expression
for ID1

Orthologs
for ID1

Paralogs
for ID1

SNPs/Variants
for ID1

Disorders & Mutations
for ID1

Medical News
for ID1

Publications
for ID1

Search for ID1

Genome Databases showing ID1

Other Databases showing ID1

Specialized Databases showing ID1

Licensable Technologies
for ID1

Services
for ID1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ID1 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor ID1

Summariesfor ID1

Genomic Locationfor ID1

Proteinsfor ID1

Protein Domains/Familiesfor ID1

Gene Functionfor ID1

Pathways & Interactionsfor ID1

Drugs & Compoundsfor ID1

Transcriptsfor ID1

Expression for ID1

Orthologsfor ID1

Paralogsfor ID1

SNPs/Variantsfor ID1

Disorders & Mutationsfor ID1

Medical Newsfor ID1

Publicationsfor ID1

Search for ID1

Genome Databases showing ID1

Other Databases showing ID1

Specialized Databases showing ID1

Licensable Technologiesfor ID1

Servicesfor ID1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ID1

Summaries
for ID1

Genomic Location
for ID1

Proteins
for ID1

Protein Domains/
Families
for ID1

Gene Function
for ID1

Pathways & Interactions
for ID1

Drugs & Compounds
for ID1

Transcripts
for ID1

Expression
for ID1

Orthologs
for ID1

Paralogs
for ID1

SNPs/Variants
for ID1

Disorders & Mutations
for ID1

Medical News
for ID1

Publications
for ID1

Licensable Technologies
for ID1

Services
for ID1