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ID1 Gene

protein-coding   GIFtS: 63
GCID: GC20P030193

Inhibitor Of DNA Binding 1, Dominant Negative Helix-Loop-Helix...

  See ID1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inhibitor Of DNA Binding 1, Dominant Negative Helix-Loop-Helix
Protein1 2
     DJ857M17.1.2 (Inhibitor Of DNA Binding 1, Dominant Negative
Helix-Loop-Helix Protein)2
DNA-Binding Protein Inhibitor ID-11 2     Inhibitor Of Differentiation 12
Class B Basic Helix-Loop-Helix Protein 242 3     BHLHB243
ID2 3     Inhibitor Of DNA Binding 13
bHLHb242 3     

External Ids:    HGNC: 53601   Entrez Gene: 33972   Ensembl: ENSG000001259687   OMIM: 6003495   UniProtKB: P411343   

Export aliases for ID1 gene to outside databases

Previous GC identifers: GC20P029981 GC20P030891 GC20P030938 GC20P029656 GC20P026981


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ID1 Gene:
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of
the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can
inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts.
This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ID1 Gene:
ID1 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein) is a protein-coding gene. Diseases associated with ID1 include prostate cancer. GO annotations related to this gene include protein dimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ID2.

UniProtKB/Swiss-Prot: ID1_HUMAN, P41134
Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form
heterodimers with other HLH proteins, thereby inhibiting DNA binding

Gene Wiki entry for ID1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the ID1 gene promoter:
         Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidID1 promoter sequence
   Search Chromatin IP Primers for ID1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ID1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11   Ensembl cytogenetic band:  20q11.21   HGNC cytogenetic band: 20q11

ID1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ID1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P030193:  view genomic region     (about GC identifiers)

Start:
30,193,086 bp from pter      End:
30,194,318 bp from pter
Size:
1,233 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ID1_HUMAN, P41134 (See protein sequence)
Recommended Name: DNA-binding protein inhibitor ID-1  
Size: 155 amino acids; 16133 Da
Subunit: Heterodimer with other HLH proteins. Interacts with COPS5 (By similarity)
Developmental stage: Expression correlates with proliferation in some types of cells
Secondary accessions: A8K537 E1P5L4 O00651 O00652 Q16371 Q16377 Q5TE66 Q5TE67 Q969Z7 Q9H0Z5
Q9H109
Alternative splicing: 2 isoforms:  P41134-1   P41134-2   

Explore the universe of human proteins at neXtProt for ID1: NX_P41134

Explore proteomics data for ID1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ID1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002156.2  NP_851998.1  

    ENSEMBL proteins: 
     ENSP00000365280   ENSP00000365273  
    Reactome Protein details: P41134

    ID1 Human Recombinant Protein Products:

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    OriGene Purified Protein for ID1
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    OriGene MassSpec for ID1
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    GenScript Custom Purified and Recombinant Proteins Services for ID1
    Novus Biologicals ID1 Proteins
    Novus Biologicals ID1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ID1
    Cloud-Clone Corp. Proteins for ID1

     
    Search eBioscience for Proteins for ID1 

     
    antibodies-online proteins for ID1 (5 products) 

     
    antibodies-online peptides for ID1

    ID1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ID1
    R&D Systems Antibodies for ID1
    OriGene Antibodies for ID1
    OriGene Custom Antibody Services for ID1
    Novus Biologicals ID1 Antibodies
    Abcam antibodies for ID1
    Cloud-Clone Corp. Antibodies for ID1
    Search ThermoFisher Antibodies for ID1
    antibodies-online antibodies for ID1 (65 products) 

    ID1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ID1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ID1
    Cloud-Clone Corp. CLIAs for ID1
    Search eBioscience for ELISAs for ID1 
    antibodies-online kits for ID1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    2 InterPro protein domains:
     IPR026052 DNA-bd_prot-inh
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry P41134

    ProtoNet protein and cluster: P41134

    UniProtKB/Swiss-Prot: ID1_HUMAN, P41134
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Find genes that share domains with ID1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ID1_HUMAN, P41134
    Function: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form
    heterodimers with other HLH proteins, thereby inhibiting DNA binding

         Genatlas biochemistry entry for ID1:
    inhibitor of DNA binding 1,putative transcription regulator,expressed during early development and in adult
    tissues,inhibiting transcription factors of the basic helix loop helix family,controlling growth and/or
    differentiation of several cell types,potentially required for neurogenesis and angiogenesis

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI15694377
    GO:0046983protein dimerization activity IEA--
         
    Find genes that share ontologies with ID1           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 5 alleles(MGI details for Id1) (see all 19):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  immune system  liver/biliary system  mortality/aging 
     muscle  nervous system  no phenotypic analysis  renal/urinary system  reproductive system 

    Find genes that share phenotypes with ID1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Id1tm1Zhu for ID1

       genOway: Develop your customized and physiologically relevant rodent model for ID1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ID1:
    hsa-mir-124-3p (MIRT022546), hsa-mir-192-5p (MIRT026397), hsa-mir-100-5p (MIRT003418), hsa-mir-26b-5p (MIRT029333), hsa-mir-215-5p (MIRT024947), hsa-mir-520h (MIRT004739)

    Block miRNA regulation of human, mouse, rat ID1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ID1 (see all 21):
    hsa-miR-495 hsa-miR-3200-5p hsa-miR-607 hsa-miR-16-2* hsa-miR-300 hsa-miR-4251 hsa-miR-330-5p hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidID1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ID1
    Predesigned siRNA for gene silencing in human, mouse, rat ID1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ID1

    Clone
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    OriGene clones in human, mouse for ID1 (see all 11)
    OriGene ORF clones in mouse, rat for ID1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ID1 (NM_017551)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ID1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ID1
    Addgene plasmids for ID1 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ID1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ID1

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-10519) for ID1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ID1_HUMAN, P41134: Cytoplasm (By similarity). Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    extracellular2
    plasma membrane2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus IDA--

    Find genes that share ontologies with ID1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ID1 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Cellular Senescence
    Cellular Senescence0.81
    Cellular responses to stress0.81
    2Immune response IL 2 activation and signaling pathway
    Immune response IL 3 activation and signaling pathway0.41
    3Ras signaling pathway
    Rap1 signaling pathway0.36
    4TGF-beta signaling pathway (KEGG)
    TGF-beta signaling pathway
    5Selected targets of p53
    Selected targets of p53


    Find genes that share SuperPaths with ID1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ID1
        Immune response IL-3 activation and signaling pathway

    5 BioSystems Pathways for ID1
        Neural Crest Differentiation
    Id Signaling Pathway
    IL-3 Signaling Pathway
    ALK1 signaling events
    Notch-mediated HES/HEY network

    1 Reactome Pathway for ID1
        Oncogene Induced Senescence


    3 Kegg Pathways  (Kegg details for ID1):
        Rap1 signaling pathway
    TGF-beta signaling pathway
    Hippo signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ID1 (see all 10): 
              TGFB/BMP Signaling Pathway in human mouse rat
              Angiogenesis in human mouse rat
              Notch Signaling Pathway in human mouse rat
              Notch Signaling Targets in human mouse rat
              Breast Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ID1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ID1 (P411341, 3 ENSP000003652804) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASKO149361, 3, ENSP000003674084EBI-1215527,EBI-1215506 I2D: score=6 STRING: ENSP00000367408
    CAV1Q031351, 3, ENSP000003391914EBI-1215527,EBI-603614 I2D: score=1 STRING: ENSP00000339191
    TCF3P159233, ENSP000002629654I2D: score=6 STRING: ENSP00000262965
    MYF6P234093, ENSP000002286414I2D: score=3 STRING: ENSP00000228641
    PSMD4P550363, ENSP000003578794I2D: score=3 STRING: ENSP00000357879
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001525angiogenesis TAS14522471
    GO:0001886endothelial cell morphogenesis IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006915apoptotic process ----

    Find genes that share ontologies with ID1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ID1

    7 Novoseek inferred chemical compound relationships for ID1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    matrigel 33.5 3 17412691 (2)
    oligonucleotide 20.9 2 15489884 (1), 12406909 (1)
    dbc-amp 16.8 2 16878319 (1), 17412691 (1)
    vegf 6.42 8 15370294 (2), 15494533 (2), 17785115 (2)
    oxygen 0 2 9748268 (1), 16840720 (1)
    zinc 0 5 16784536 (2), 17928372 (1), 17307745 (1)
    tyrosine 0 6 18559972 (2), 17418011 (1), 19643984 (1), 18381431 (1) (see all 5)



    Find genes that share compounds with ID1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ID1 gene (2 alternative transcripts): 
    NM_002165.3  NM_181353.2  

    Unigene Cluster for ID1:

    Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
    Hs.504609  [show with all ESTs]
    Unigene Representative Sequence: BG165657
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376112(uc002wwg.2) ENST00000376105(uc002wwh.2)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ID1 (see all 21):
    hsa-miR-495 hsa-miR-3200-5p hsa-miR-607 hsa-miR-16-2* hsa-miR-300 hsa-miR-4251 hsa-miR-330-5p hsa-miR-7-1*
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    GenScript: all cDNA clones in your preferred vector: ID1 (NM_017551)
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    Addgene plasmids for ID1 
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    OriGene qSTAR qPCR primer pairs in human, mouse for ID1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ID1
      QuantiTect SYBR Green Assays in human, mouse, rat ID1
      QuantiFast Probe-based Assays in human, mouse, rat ID1
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-10519) for ID1 

    Additional mRNA sequence: 

    AK291152.1 AK313786.1 BC000613.2 BC012420.1 BT007443.1 D13889.1 D13890.1 S78825.1 
    S78986.1 X77956.1 

    11 DOTS entries:

    DT.449322  DT.100674315  DT.95360225  DT.100674312  DT.100852491  DT.92026432  DT.100674319  DT.100858114 
    DT.120828837  DT.91767771  DT.95360242 

    Selected AceView cDNA sequences (see all 765):

    CB142043 BF725183 BM836285 CB144504 AI310349 BQ940719 CR626444 BM755815 
    BM762174 BM762850 BQ695339 CB148476 BM840893 BQ084038 BM746814 BQ229985 
    CK823341 BM971637 BQ219146 CB145589 BQ695279 BM679734 BQ083861 BQ183877 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ID1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGTTCCTGCG
    ID1 Expression
    About this image


    ID1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 24) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 12 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 11 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+BMP4-induced E15 cells
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
             Midbrain dopaminergic-like neurons
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Vascular endothelial growth factor-induced cells
    ID1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ID1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.504609
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ID1 (see all 10): 
              TGFB/BMP Signaling Pathway in human mouse rat
              Angiogenesis in human mouse rat
              Notch Signaling Pathway in human mouse rat
              Notch Signaling Targets in human mouse rat
              Breast Cancer in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ID1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ID1
    QuantiTect SYBR Green Assays in human, mouse, rat ID1
    QuantiFast Probe-based Assays in human, mouse, rat ID1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ID1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ID1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Id11 , 5 inhibitor of DNA binding 11, 5 89.38(n)1
    94.81(a)1
      2 (75.41 cM)5
    159011  NM_010495.31  NP_034625.11 
     1527362515 
    chicken
    (Gallus gallus)
    Aves ID11 inhibitor of DNA binding 1, dominant negative helix-loop-helix more 68.13(n)
    64.84(a)
      395282  NM_204590.1  NP_989921.1 
    zebrafish
    (Danio rerio)
    Actinopterygii id11 inhibitor of DNA binding 1 66.94(n)
    63.11(a)
      30493  NM_131245.1  NP_571320.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta emc6
    extra macrochaetae
    18(a)
    1 → many
    3L(749400-753492)


    ENSEMBL Gene Tree for ID1 (if available)
    TreeFam Gene Tree for ID1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ID1 gene
    ID22  ID32  ID42  
    3 SIMAP similar genes for ID1 using alignment to 1 protein entry:     ID1_HUMAN:
    ID2    ID3    ID4

    Find genes that share paralogs with ID1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ID1 (see all 162)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1817592411,2
    --30204305(+) AATCTC/TGGCTC 2 -- us2k10--------
    rs736137131,2
    C--30204439(+) CACCAC/TGTTGG 2 -- us2k10--------
    rs1863761791,2
    C--30204450(+) TCAGGC/GTGGTC 2 -- us2k10--------
    rs1905336621,2
    --30204521(+) GTGAGA/CCACTG 2 -- us2k10--------
    rs61195741,2
    C,F,A--30204594(+) AGGCTG/TGAGTG 2 -- us2k12Minor allele frequency- T:0.25NA WA 4
    rs1807513011,2
    --30204608(+) TGGTGC/TGATCT 2 -- us2k10--------
    rs61195751,2
    C,F--30204671(+) CTCCCG/CAGTAG 2 -- us2k11Minor allele frequency- C:0.50NA 2
    rs1461138401,2
    --30204826(+) CAGGCA/GTGAGC 2 -- us2k10--------
    rs622046431,2
    C--30204979(+) ATTAAA/GTATTA 2 -- us2k12Minor allele frequency- G:0.08NA 122
    rs790952981,2
    C,F--30205093(+) GAGGTG/AGGGGG 2 -- us2k11Minor allele frequency- A:0.03NA 120

    HapMap Linkage Disequilibrium report for ID1 (30193086 - 30194318 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ID1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv458961CNV Gain19166990
    nsv470546CNV Gain18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ID1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600349    OMIM disorders: --

    1 disease for ID1:    
    About MalaCards
    prostate cancer

    1 disease from the University of Copenhagen DISEASES database for ID1:
    Prostate cancer

    Find genes that share disorders with ID1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ID1 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 30.4 64 20414347 (6), 17108123 (6), 18752043 (3), 17565736 (2) (see all 25)
    neovascularization 25 3 16267257 (1), 15494533 (1), 16136355 (1)
    erythroleukemia 16.3 2 7629100 (2)
    cancer 14.9 24 20235117 (3), 18381431 (2), 14755252 (2), 9070860 (1) (see all 9)
    prostate cancer 14.2 12 18752043 (4), 20388787 (3), 20186495 (2), 17108123 (2)
    chondrosarcoma 12.7 4 16273214 (2), 9821964 (1)
    melanoma 8.58 39 11507043 (6), 17565736 (5), 18240291 (4), 16189525 (4) (see all 6)
    metastasis 7.29 12 19491902 (4), 19801974 (2), 20388805 (1), 15342397 (1) (see all 6)
    metastatic melanoma 7.17 2 15596294 (1), 11507043 (1)
    breast cancer 6.2 14 18048329 (2), 19217708 (2), 19801974 (2), 18413773 (2) (see all 7)

    Genetic Association Database (GAD): ID1
    Human Genome Epidemiology (HuGE) Navigator: ID1 (3 documents)

    Export disorders for ID1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ID1 gene, integrated from 10 sources (see all 337):
    (articles sorted by number of sources associating them with ID1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. (PubMed id 8294468)1, 2, 3 Hara E....Oda K. (J. Biol. Chem. 1994)
    2. Genomic organization, sequence, and chromosomal localization of the human helix-loop-helix Id1 gene. (PubMed id 9070860)1, 2, 9 Nehlin J.O.... Campisi J. (Biochem. Biophys. Res. Commun. 1997)
    3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    6. Id gene expression during development and molecular cloning of the human Id-1 gene. (PubMed id 7637581)1, 2 Zhu W.... Israel M.A. (Brain Res. Mol. Brain Res. 1995)
    7. Nucleotide sequence of the cDNA encoding human helix-loop-helix Id-1 protein: identification of functionally conserved residues common to Id proteins. (PubMed id 8086456)1, 2 Deed R.W.... Norton J.D. (Biochim. Biophys. Acta 1994)
    8. ID1, inhibitor of differentiation/DNA binding, is an effector of the p53-dependent DNA damage response pathway. (PubMed id 18556654)1, 9 Qian Y. and Chen X. (J. Biol. Chem. 2008)
    9. Id1 gene expression is up-regulated in hyperplastic and neoplastic thyroid tissue and regulates growth and differentiation in thyroid cancer cells. (PubMed id 15579766)1, 9 Kebebew E....Miner R. (J. Clin. Endocrinol. Metab. 2004)
    10. ID1 enhances docetaxel cytotoxicity in prostate cancer cells through inhibition of p21. (PubMed id 20388787)1, 9 Geng H....Qian D.Z. (Cancer Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3397 HGNC: 5360 AceView: ID1 Ensembl:ENSG00000125968 euGenes: HUgn3397
    ECgene: ID1 Kegg: 3397 H-InvDB: ID1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ID1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ID1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ID1 gene:
    Search GeneIP for patents involving ID1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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