Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ICT1 Gene

Aliases for ICT1 Gene

  • Immature Colon Carcinoma Transcript 1 2 3 5
  • Immature Colon Carcinoma Transcript 1 Protein 3 4
  • 39S Ribosomal Protein L58, Mitochondrial 3 4
  • Digestion Substraction 1 3 4
  • MRP-L58 3 4
  • DS-1 3 4
  • DS1 3 4
  • EC 3.1.1.29 4

External Ids for ICT1 Gene

Previous GeneCards Identifiers for ICT1 Gene

  • GC17M072980
  • GC17P076067
  • GC17P073472
  • GC17P073605
  • GC17P070520
  • GC17P073008
  • GC17P068419

Summaries for ICT1 Gene

Entrez Gene Summary for ICT1 Gene

  • The protein encoded by this gene is a peptidyl-tRNA hydrolase and a vital component of the large mitochondrial ribosome. The encoded protein serves as a ribosome release factor for this ribosome, which translates mitochondrial genes. This protein may be responsible for degrading prematurely-terminated polypeptides and for reusing stalled ribosomes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for ICT1 Gene

ICT1 (Immature Colon Carcinoma Transcript 1) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. GO annotations related to this gene include translation release factor activity and translation release factor activity, codon nonspecific.

UniProtKB/Swiss-Prot for ICT1 Gene

  • Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICT1 Gene

Genomics for ICT1 Gene

Regulatory Elements for ICT1 Gene

Promoters for ICT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ICT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ICT1 Gene

Chromosome:
17
Start:
75,012,664 bp from pter
End:
75,021,261 bp from pter
Size:
8,598 bases
Orientation:
Plus strand

Genomic View for ICT1 Gene

Genes around ICT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICT1 Gene

Proteins for ICT1 Gene

  • Protein details for ICT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14197-ICT1_HUMAN
    Recommended name:
    Peptidyl-tRNA hydrolase ICT1, mitochondrial
    Protein Accession:
    Q14197
    Secondary Accessions:
    • B2RAD1
    • Q53HM7
    • Q53Y11

    Protein attributes for ICT1 Gene

    Size:
    206 amino acids
    Molecular mass:
    23630 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.

    Three dimensional structures from OCA and Proteopedia for ICT1 Gene

neXtProt entry for ICT1 Gene

Proteomics data for ICT1 Gene at MOPED

Post-translational modifications for ICT1 Gene

  • Ubiquitination at Lys 47 and Lys 66
  • Modification sites at PhosphoSitePlus

Other Protein References for ICT1 Gene

Antibody Products

No data available for DME Specific Peptides for ICT1 Gene

Domains & Families for ICT1 Gene

Protein Domains for ICT1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ICT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14197

UniProtKB/Swiss-Prot:

ICT1_HUMAN :
  • Belongs to the prokaryotic/mitochondrial release factor family. ICT1 subfamily.
Family:
  • Belongs to the prokaryotic/mitochondrial release factor family. ICT1 subfamily.
genes like me logo Genes that share domains with ICT1: view

No data available for Gene Families for ICT1 Gene

Function for ICT1 Gene

Molecular function for ICT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
N-substituted aminoacyl-tRNA + H(2)O = N-substituted amino acid + tRNA.
UniProtKB/Swiss-Prot Function:
Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.

Enzyme Numbers (IUBMB) for ICT1 Gene

genes like me logo Genes that share phenotypes with ICT1: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ICT1 Gene

Localization for ICT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICT1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ICT1 Gene COMPARTMENTS Subcellular localization image for ICT1 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ICT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005762 mitochondrial large ribosomal subunit IDA 20186120
genes like me logo Genes that share ontologies with ICT1: view

Pathways & Interactions for ICT1 Gene

genes like me logo Genes that share pathways with ICT1: view

Gene Ontology (GO) - Biological Process for ICT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006415 translational termination IEA --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with ICT1: view

No data available for SIGNOR curated interactions for ICT1 Gene

Drugs & Compounds for ICT1 Gene

(1) Additional Compounds for ICT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with ICT1: view

Transcripts for ICT1 Gene

Unigene Clusters for ICT1 Gene

Immature colon carcinoma transcript 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ICT1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6
SP1: - -
SP2: -
SP3: -

Relevant External Links for ICT1 Gene

GeneLoc Exon Structure for
ICT1
ECgene alternative splicing isoforms for
ICT1

Expression for ICT1 Gene

mRNA expression in normal human tissues for ICT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ICT1 Gene

This gene is overexpressed in Lung (33.4), Tlymphocyte (7.3), and Pancreas (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ICT1 Gene



SOURCE GeneReport for Unigene cluster for ICT1 Gene Hs.407955

mRNA Expression by UniProt/SwissProt for ICT1 Gene

Q14197-ICT1_HUMAN
Tissue specificity: Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells.
genes like me logo Genes that share expression patterns with ICT1: view

Protein tissue co-expression partners for ICT1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ICT1 Gene

Orthologs for ICT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ICT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ICT1 35
  • 99.19 (n)
  • 99.03 (a)
ICT1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ICT1 36
  • 79 (a)
OneToOne
ICT1 35
  • 83.17 (n)
  • 80.1 (a)
dog
(Canis familiaris)
Mammalia ICT1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ict1 16
Ict1 36
  • 80 (a)
OneToOne
Ict1 35
  • 81.73 (n)
  • 79.66 (a)
oppossum
(Monodelphis domestica)
Mammalia ICT1 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ICT1 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ict1 35
  • 81.72 (n)
  • 80.1 (a)
chicken
(Gallus gallus)
Aves ICT1 36
  • 59 (a)
OneToOne
ICT1 35
  • 63.53 (n)
  • 62.83 (a)
lizard
(Anolis carolinensis)
Reptilia ICT1 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ict1 35
  • 60.34 (n)
  • 59.77 (a)
Str.10297 35
zebrafish
(Danio rerio)
Actinopterygii ICT1 36
  • 44 (a)
OneToOne
LOC100149182 35
  • 57.86 (n)
  • 52.14 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008425 35
  • 48.08 (n)
  • 44.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6094 36
  • 37 (a)
OneToOne
CG6094 35
  • 49.8 (n)
  • 43.29 (a)
worm
(Caenorhabditis elegans)
Secernentea R02F2.9 35
  • 46.91 (n)
  • 40 (a)
R02F2.9 36
  • 35 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 27 (a)
OneToOne
PTH4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G62850 35
  • 48.48 (n)
  • 37.76 (a)
rice
(Oryza sativa)
Liliopsida Os03g0249200 35
  • 49.52 (n)
  • 42.75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.345 36
  • 33 (a)
OneToOne
Species with no ortholog for ICT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ICT1 Gene

ENSEMBL:
Gene Tree for ICT1 (if available)
TreeFam:
Gene Tree for ICT1 (if available)

Paralogs for ICT1 Gene

No data available for Paralogs for ICT1 Gene

Variants for ICT1 Gene

Sequence variations from dbSNP and Humsavar for ICT1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs3744206 - 75,012,709(+) CCTGC(C/G/T)CTGGG reference, missense
rs10512599 - 75,019,707(-) ATTGT(C/G)AAGCG reference, missense
rs34496172 - 75,020,394(+) CATCA(C/T)GGTAA reference, missense
rs1142761 -- 75,015,398(+) agaat(C/T)gcttg intron-variant
rs4788856 -- 75,017,819(+) CTCGG(A/G)AGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ICT1 Gene

Variant ID Type Subtype PubMed ID
nsv908744 CNV Loss 21882294
nsv833540 CNV Loss 17160897
dgv3254n71 CNV Loss 21882294
nsv908753 CNV Loss 21882294

Variation tolerance for ICT1 Gene

Residual Variation Intolerance Score: 74.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ICT1 Gene

HapMap Linkage Disequilibrium report
ICT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICT1 Gene

Disorders for ICT1 Gene

Relevant External Links for ICT1

Genetic Association Database (GAD)
ICT1
Human Genome Epidemiology (HuGE) Navigator
ICT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ICT1

No disorders were found for ICT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ICT1 Gene

Publications for ICT1 Gene

  1. Identification of mRNAs that show modulated expression during colon carcinoma cell differentiation. (PMID: 8575443) van Belzen N. … Bosman F.T. (Eur. J. Biochem. 1995) 2 3 4 23 67
  2. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PMID: 20186120) Richter R. … Chrzanowska-Lightowlers Z.M. (EMBO J. 2010) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3

Products for ICT1 Gene

Sources for ICT1 Gene

Back to Top

Content