Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ICT1 Gene

protein-coding   GIFtS: 51
GCID: GC17P073008

immature colon carcinoma transcript 1

 Explore 6 diseases affiliated with
ICT1 via our new
 Human Malady Compendium 
Biological research products
for ICT1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Immature Colon Carcinoma Transcript 11 2     DS12 3
DS-11 2 3     Peptidyl-TRNA Hydrolase ICT1, Mitochondrial2
Digestion Substraction 12 3     EC 3.1.1.293
Immature Colon Carcinoma Transcript 1 Protein2 3     

External Ids:    HGNC: 53591   Entrez Gene: 33962   Ensembl: ENSG000001678627   OMIM: 6030005   UniProtKB: Q141973   

Export aliases for ICT1 gene to outside databases

Previous GC identifers: GC17M072980 GC17P076067 GC17P073472 GC17P073605 GC17P070520 GC17P068419


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ICT1:
The adult colon epithelium contains 3 differentiated cell types that arise from a multipotent stem cell. Deviation from
the normal maturation pathway by neoplastic transformation is thought to initiate in stem cells or their early
descendants. One potential marker is ICT1 whose mRNA and protein were more highly expressed in undifferentiated than
in differentiated cells. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ICT1_HUMAN, Q14197
Function: Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a
codon-independent translation release factor that has lost all stop codon specificity and directs the termination of
translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of
peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ICT1 gene promoter:
         USF1   C/EBPbeta   RFX1   Brachyury   Nkx2-5   PPAR-alpha   FOXC1   Zic1   USF-1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidICT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ICT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ICT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25

ICT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ICT1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P073008:  view genomic region     (about GC identifiers)

Start:
73,008,765 bp from pter      End:
73,017,356 bp from pter
Size:
8,592 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ICT1_HUMAN, Q14197 (See protein sequence)
Recommended Name: Peptidyl-tRNA hydrolase ICT1, mitochondrial precursor  
Size: 206 amino acids; 23630 Da
Subunit: Component of the mitochondrial 39S ribosomal subunit
Subcellular location: Mitochondrion
Caution: In contrast to other members of the family, lacks the regions that come into close contact with the mRNA in
the ribosomal A-site and determine the STOP codon specificity, explaining the loss of codon specificity for
translation release factor activity
Secondary accessions: B2RAD1 Q53HM7 Q53Y11

Explore the universe of human proteins at neXtProt for ICT1: NX_Q14197

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14197

  • ICT1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001536.1  
    ENSEMBL proteins: 
     ENSP00000462256   ENSP00000301585   ENSP00000464192  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ICT1
    OriGene Protein Over-expression Lysate: ICT1
    OriGene Custom Protein Services for ICT1 
    GenScript Custom Purified and Recombinant Proteins Services for ICT1
    Novus Biologicals ICT1 Protein
    Novus Biologicals ICT1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ICT1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005762mitochondrial large ribosomal subunit IDA--


    ICT1 for ontologies           About GeneDecksing



    ICT1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: ICT1
    OriGene Custom Antibody Services for ICT1 
    GenScript Custom Superior Antibodies Services for ICT1
    Novus Biologicals ICT1 Antibodies
    Search for Antibodies for ICT1 at Abcam  
    Uscn Antibodies for ICT1
    Search ThermoFisher Antibodies for ICT1

    Assay Products for ICT1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ICT1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ICT1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ICT1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000352 Pep_chain_release_fac_I_II

    Graphical View of Domain Structure for InterPro Entry Q14197

    ProtoNet protein and cluster: Q14197

    UniProtKB/Swiss-Prot: ICT1_HUMAN, Q14197
    Similarity: Belongs to the prokaryotic/mitochondrial release factor family. ICT1 subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ICT1_HUMAN, Q14197
    Function: Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a
    codon-independent translation release factor that has lost all stop codon specificity and directs the termination of
    translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of
    peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes
    Catalytic activity: N-substituted aminoacyl-tRNA + H(2)O = N-substituted amino acid + tRNA

    Enzyme Number (IUBMB): EC 3.1.1.291

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: ICT1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ICT1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ICT1
    SwitchGear 3'UTR luciferase reporter plasmidICT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ICT1 (see all 4)
    OriGene shRNA RFP: ICT1
    OriGene siRNA: ICT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ICT1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ICT1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ICT1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ICT1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ICT1 (NM_001545)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ICT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICT1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ICT1
    Search LifeMap BioReagents cell lines for ICT1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICT1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004045aminoacyl-tRNA hydrolase activity IDA--
    GO:0016150translation release factor activity, codon nonspecific IDA--


    ICT1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ICT1:
     Decreased POU5F1-GFP protein e 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ICT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/280 Interacting proteins for ICT1 (Q141972, 3 ENSP000003015854) via UniProtKB, MINT, STRING, and/or I2D (see all 280)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DAP3P513982, 3, ENSP000003416924MINT-8079752 MINT-8079764 MINT-8079030 MINT-8079734 I2D: score=1 STRING: ENSP00000341692
    ACAD9Q9H8452, 3, ENSP000003126184MINT-8079030 I2D: score=1 STRING: ENSP00000312618
    AFG3L2Q9Y4W62, 3, ENSP000002691434MINT-8079030 I2D: score=1 STRING: ENSP00000269143
    ALDH18A1P548862, 3, ENSP000003602684MINT-8079030 I2D: score=1 STRING: ENSP00000360268
    ALDH2P050912, 3, ENSP000002617334MINT-8079030 I2D: score=1 STRING: ENSP00000261733
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0070126mitochondrial translational termination IDA--


    ICT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ICT1
    Search CenterWatch for drugs/clinical trials and news about ICT1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ICT1 gene: 
    NM_001545.1  

    Unigene Cluster for ICT1:

    Immature colon carcinoma transcript 1
    Hs.407955  [show with all ESTs]
    Unigene Representative Sequence: BG177089
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000584208 ENST00000301585(uc002jmm.3) ENST00000580800 ENST00000583772


    miRNA
    Products:
         
    OriGene 3'-UTR Clone: ICT1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ICT1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ICT1
    SwitchGear 3'UTR luciferase reporter plasmidICT1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ICT1 (see all 4)
    OriGene shRNA RFP: ICT1
    OriGene siRNA: ICT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ICT1
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ICT1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ICT1 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ICT1 (NM_001545)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ICT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICT1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ICT1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ICT1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ICT1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ICT1

    Additional cDNA sequence: 

    AK222553.1 AK314138.1 BC015335.1 BT007111.1 X81788.1 

    4 DOTS entries:

    DT.312338  DT.97843678  DT.97843679  DT.95287871 

    24/94 AceView cDNA sequences (see all 94):

    AA988569 BM831439 BM790637 BM821741 BF724521 CA337908 BM773354 T49953 
    BM781675 BM785123 AA524079 BM726088 AI692751 BM850252 BG178129 AI688512 
    BC015335 BM744821 AA642525 CB142973 BM764915 BM831332 BU161221 AA307839 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ICT1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6
    SP1:        -                 -                           
    SP2:                          -                           
    SP3:        -                                             


    ECgene alternative splicing isoforms for ICT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ICT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATTAGTCAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ICT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ICT1

    SOURCE GeneReport for Unigene cluster: Hs.407955

    UniProtKB/Swiss-Prot: ICT1_HUMAN, Q14197
    Tissue specificity: Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells

        SABiosciences Custom PCR Arrays for ICT1
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ICT1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ICT1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ICT1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ICT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for ICT1 gene from 10/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ict11 , 5 immature colon carcinoma transcript 11, 5 81.73(n)1
    79.66(a)1
      11 (80.84 cM)5
    685721  NM_026729.11  NP_081005.11 
     1154037525 
    chicken
    (Gallus gallus)
    Aves ICT11 immature colon carcinoma transcript 1 63.35(n)
    62.3(a)
      422114  XM_420117.3  XP_420117.2 
    lizard
    (Anolis carolinensis)
    Reptilia ICT16
    --
    57(a)
    1 ↔ 1
    2(114953519-114960321)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD363285.12   -- 79.84(n)    CD363285.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001491821 peptidyl-tRNA hydrolase ICT1, mitochondrial-like 58.52(n)
    53.33(a)
      100149182  XM_001922675.2  XP_001922710.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG60941 CG6094 49.59(n)
    43.29(a)
      34446  NM_135572.2  NP_609416.1 
    worm
    (Caenorhabditis elegans)
    Secernentea R02F2.91 Protein R02F2.9 46.91(n)
    40(a)
      259963  NM_065773.4  NP_498174.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G628501 Class I peptide chain release factor 48.48(n)
    37.76(a)
      842585  NM_001084291.1  NP_001077760.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g02492001 hypothetical protein 48.53(n)
    38.78(a)
      4332255  NM_001056093.1  NP_001049558.1 
    E. coli
    (Escherichia coli)
    Gamma proteobacteria yaeJ6
    petidyl-tRNA hydrolase, ribosome-attached; stalled...
    23(a)
    1 ↔ 1
    Chromosome(214833-215255)


    ENSEMBL Gene Tree for ICT1 (if available)
    TreeFam Gene Tree for ICT1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/215 NCBI SNPs in ICT1 are shown (see all 215    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1500283881,2
    --73006820(+) AGGGCA/GGTACA 1 -- us2k10--------
    rs1451073051,2
    C,--73006840(+) AAAGG-/GGTC  
     CTATGTA
    GGTCC
    1 -- us2k10--------
    rs1443977201,2
    --73006955(+) CTTTCC/TTCTCT 1 -- us2k10--------
    rs1835611371,2
    --73006987(+) CTGAAA/GCACCA 1 -- us2k10--------
    rs99071771,2
    C,F,H,--73006996(+) CATCTC/TGGCCT 1 -- us2k118Minor allele frequency- T:0.17NS EA NA CSA 2226
    rs1153953981,2
    C,F,--73007234(+) ATGGCC/TCAAGC 1 -- us2k11Minor allele frequency- T:0.16WA 118
    rs1401720371,2
    --73007376(+) CCTTAG/TCCCCC 1 -- us2k10--------
    rs1431932961,2
    --73007435(+) TGCCAC/TAGAGA 1 -- us2k10--------
    rs1466639401,2
    --73007510(+) CCCAAC/TCCGAG 1 -- us2k10--------
    rs1403112331,2
    --73007537(+) GTCAAC/TTGTCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ICT1 (73008765 - 73017356 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ICT1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ICT1
    DNA2.0 Custom Variant and Variant Library Synthesis for ICT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ICT1 for disorders           About GeneDecksing

    OMIM gene information: 603000    OMIM disorders: --

    6 diseases for ICT1:    About MalaCards
    colon carcinoma    carcinoma    gastroenteritis    diarrhea
    colorectal cancer    malaria

    2 diseases from the University of Copenhagen DISEASES database for ICT1:
    Gastroenteritis     Diarrhea
    Human Genome Epidemiology (HuGE) Navigator: ICT1 (1 document)

    Export disorders for ICT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ICT1 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with ICT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of mRNAs that show modulated expression during colon carcinoma cell differentiation. (PubMed id 8575443)1, 2, 3, 9 van Belzen N.... Bosman F.T. (1995)
    2. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1, 2, 3 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Functional genomics identifies therapeutic targets for MYC-driven cancer. (PubMed id 22623531)1 Toyoshima M....Grandori C. (2012)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    9. Mutations in C12orf65 in patients with encephalomyopa thy and a mitochondrial translation defect. (PubMed id 20598281)1 Antonicka H....Shoubridge E.A. (2010)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3396 HGNC: 5359 AceView: ICT1 Ensembl:ENSG00000167862 euGenes: HUgn3396
    ECgene: ICT1 H-InvDB: ICT1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ICT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ICT1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ICT1 gene:
    Search GeneIP for patents involving ICT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for ICT1   OriGene shRNA RFP for ICT1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ICT1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ICT1  
     OriGene Protein Over-expression Lysate for ICT1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ICT1   OriGene 3'-UTR Clone for ICT1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ICT1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ICT1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for ICT1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ICT1   OriGene Custom Protein Services for ICT1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ICT1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ICT1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ICT1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ICT1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ICT1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ICT1
     GenScript Custom Purified and Recombinant Proteins Services for ICT1 GenScript cDNA clones with any tag delivered in your preferred vector for ICT1
     GenScript Custom Assay Services for ICT1 GenScript Custom Superior Antibodies Services for ICT1
     GenScript Custom overexpressing Cell Line Services for ICT1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ICT1 promoter
     Search Chromatin IP Primers for ICT1
     RT2 qPCR Primer Assay in human, mouse, rat ICT1
     Search GNC Networks for ICT1
     SABiosciences Custom PCR Arrays for ICT1
     Search Tocris compounds for ICT1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ICT1 antibodies
     ICT1 proteins
     ICT1 lysates
     Search for Antibodies for ICT1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ICT1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ICT1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ICT1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICT1
     SwitchGear 3'UTR luciferase reporter plasmids for ICT1
     SwitchGear Promoter luciferase reporter plasmids for ICT1
     Search ThermoFisher Antibodies for ICT1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICT1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ICT1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4