Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ICT1 Gene

Aliases for ICT1 Gene

  • Immature Colon Carcinoma Transcript 1 2 3
  • DS1 3 4 6
  • Immature Colon Carcinoma Transcript 1 Protein 3 4
  • 39S Ribosomal Protein L58, Mitochondrial 3 4
  • Digestion Substraction 1 3 4
  • MRP-L58 3 4
  • DS-1 3 4
  • Peptidyl-TRNA Hydrolase ICT1, Mitochondrial 3
  • EC 3.1.1.29 4

External Ids for ICT1 Gene

Previous GeneCards Identifiers for ICT1 Gene

  • GC17M072980
  • GC17P076067
  • GC17P073472
  • GC17P073605
  • GC17P070520
  • GC17P073008
  • GC17P068419

Summaries for ICT1 Gene

Entrez Gene Summary for ICT1 Gene

  • The protein encoded by this gene is a peptidyl-tRNA hydrolase and a vital component of the large mitochondrial ribosome. The encoded protein serves as a ribosome release factor for this ribosome, which translates mitochondrial genes. This protein may be responsible for degrading prematurely-terminated polypeptides and for reusing stalled ribosomes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for ICT1 Gene

ICT1 (Immature Colon Carcinoma Transcript 1) is a Protein Coding gene. GO annotations related to this gene include aminoacyl-tRNA hydrolase activity and translation release factor activity, codon nonspecific.

UniProtKB/Swiss-Prot for ICT1 Gene

  • Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICT1 Gene

Genomics for ICT1 Gene

Regulatory Elements for ICT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ICT1 Gene

Start:
75,012,670 bp from pter
End:
75,021,261 bp from pter
Size:
8,592 bases
Orientation:
Plus strand

Genomic View for ICT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ICT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICT1 Gene

Proteins for ICT1 Gene

  • Protein details for ICT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14197-ICT1_HUMAN
    Recommended name:
    Peptidyl-tRNA hydrolase ICT1, mitochondrial
    Protein Accession:
    Q14197
    Secondary Accessions:
    • B2RAD1
    • Q53HM7
    • Q53Y11

    Protein attributes for ICT1 Gene

    Size:
    206 amino acids
    Molecular mass:
    23630 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.

    Three dimensional structures from OCA and Proteopedia for ICT1 Gene

neXtProt entry for ICT1 Gene

Proteomics data for ICT1 Gene at MOPED

Post-translational modifications for ICT1 Gene

  • Ubiquitination at Lys47 and Lys66
  • Modification sites at PhosphoSitePlus

Other Protein References for ICT1 Gene

Antibody Products

No data available for DME Specific Peptides for ICT1 Gene

Domains for ICT1 Gene

Protein Domains for ICT1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ICT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14197

UniProtKB/Swiss-Prot:

ICT1_HUMAN :
  • Q14197
Family:
  • Belongs to the prokaryotic/mitochondrial release factor family. ICT1 subfamily.
genes like me logo Genes that share domains with ICT1: view

No data available for Gene Families for ICT1 Gene

Function for ICT1 Gene

Molecular function for ICT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
N-substituted aminoacyl-tRNA + H(2)O = N-substituted amino acid + tRNA
UniProtKB/Swiss-Prot Function:
Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.

Enzyme Numbers (IUBMB) for ICT1 Gene

Gene Ontology (GO) - Molecular Function for ICT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003747 translation release factor activity --
GO:0004045 aminoacyl-tRNA hydrolase activity IDA 20186120
GO:0016150 translation release factor activity, codon nonspecific IDA 20186120
genes like me logo Genes that share ontologies with ICT1: view

Phenotypes for ICT1 Gene

GenomeRNAi human phenotypes for ICT1:
genes like me logo Genes that share phenotypes with ICT1: view

Animal Model Products

miRNA for ICT1 Gene

miRTarBase miRNAs that target ICT1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ICT1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ICT1 Gene

Localization for ICT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICT1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ICT1 Gene COMPARTMENTS Subcellular localization image for ICT1 gene
Compartment Confidence
mitochondrion 5
cytosol 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ICT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 20186120
GO:0005743 mitochondrial inner membrane TAS --
GO:0005759 mitochondrial matrix TAS --
GO:0005762 mitochondrial large ribosomal subunit IDA 20186120
genes like me logo Genes that share ontologies with ICT1: view

Pathways for ICT1 Gene

SuperPathways for ICT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ICT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006415 translational termination --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with ICT1: view

No data available for Pathways by source for ICT1 Gene

Transcripts for ICT1 Gene

Unigene Clusters for ICT1 Gene

Immature colon carcinoma transcript 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ICT1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ICT1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6
SP1: - -
SP2: -
SP3: -

Relevant External Links for ICT1 Gene

GeneLoc Exon Structure for
ICT1
ECgene alternative splicing isoforms for
ICT1

Expression for ICT1 Gene

mRNA expression in normal human tissues for ICT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ICT1 Gene

This gene is overexpressed in Lung (33.4), Tlymphocyte (7.3), and Pancreas (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ICT1 Gene

SOURCE GeneReport for Unigene cluster for ICT1 Gene Hs.407955

mRNA Expression by UniProt/SwissProt for ICT1 Gene

Q14197-ICT1_HUMAN
Tissue specificity: Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells.
genes like me logo Genes that share expressions with ICT1: view

Expression partners for ICT1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ICT1 Gene

Orthologs for ICT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ICT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ICT1 35
  • 83.17 (n)
  • 80.1 (a)
ICT1 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ict1 35
  • 81.73 (n)
  • 79.66 (a)
Ict1 16
Ict1 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ICT1 35
  • 99.19 (n)
  • 99.03 (a)
ICT1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ict1 35
  • 81.72 (n)
  • 80.1 (a)
dog
(Canis familiaris)
Mammalia ICT1 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ICT1 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ICT1 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ICT1 35
  • 63.53 (n)
  • 62.83 (a)
ICT1 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ICT1 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ict1 35
  • 60.34 (n)
  • 59.77 (a)
Str.10297 35
zebrafish
(Danio rerio)
Actinopterygii LOC100149182 35
  • 57.86 (n)
  • 52.14 (a)
ICT1 36
  • 44 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008425 35
  • 48.08 (n)
  • 44.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6094 35
  • 49.8 (n)
  • 43.29 (a)
CG6094 36
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R02F2.9 35
  • 46.91 (n)
  • 40 (a)
R02F2.9 36
  • 35 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 27 (a)
OneToOne
-- 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G62850 35
  • 48.48 (n)
  • 37.76 (a)
rice
(Oryza sativa)
Liliopsida Os03g0249200 35
  • 49.52 (n)
  • 42.75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.345 36
  • 33 (a)
OneToOne
Species with no ortholog for ICT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ICT1 Gene

ENSEMBL:
Gene Tree for ICT1 (if available)
TreeFam:
Gene Tree for ICT1 (if available)

Paralogs for ICT1 Gene

No data available for Paralogs for ICT1 Gene

Variants for ICT1 Gene

Sequence variations from dbSNP and Humsavar for ICT1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs902726 -- 75,020,161(-) AAGCC(C/T)GCAAA intron-variant
rs1142761 -- 75,015,398(+) agaat(C/T)gcttg intron-variant
rs2035833 -- 75,020,805(-) TAGCC(C/T)GCAGG intron-variant
rs3744206 - 75,012,709(+) CCTGC(C/G/T)CTGGG missense, reference
rs4788856 -- 75,017,819(+) CTCGG(A/G)AGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ICT1 Gene

Variant ID Type Subtype PubMed ID
nsv908744 CNV Loss 21882294
nsv833540 CNV Loss 17160897
dgv3254n71 CNV Loss 21882294
nsv908753 CNV Loss 21882294

Relevant External Links for ICT1 Gene

HapMap Linkage Disequilibrium report
ICT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICT1 Gene

Disorders for ICT1 Gene

(2) University of Copenhagen DISEASES for ICT1 Gene

Relevant External Links for ICT1

Genetic Association Database (GAD)
ICT1
Human Genome Epidemiology (HuGE) Navigator
ICT1
genes like me logo Genes that share disorders with ICT1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for ICT1 Gene

Publications for ICT1 Gene

  1. Identification of mRNAs that show modulated expression during colon carcinoma cell differentiation. (PMID: 8575443) van Belzen N. … Bosman F.T. (Eur. J. Biochem. 1995) 2 3 4 23
  2. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PMID: 20186120) Richter R. … Chrzanowska-Lightowlers Z.M. (EMBO J. 2010) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for ICT1 Gene

Sources for ICT1 Gene

Back to Top

Content