Aliases for ICT1 Gene
External Ids for ICT1 Gene
The protein encoded by this gene is a peptidyl-tRNA hydrolase and a vital component of the large mitochondrial ribosome. The encoded protein serves as a ribosome release factor for this ribosome, which translates mitochondrial genes. This protein may be responsible for degrading prematurely-terminated polypeptides and for reusing stalled ribosomes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
GeneCards Summary for ICT1 Gene
ICT1 (Immature Colon Carcinoma Transcript 1) is a Protein Coding gene. GO annotations related to this gene include aminoacyl-tRNA hydrolase activity and translation release factor activity, codon nonspecific.
UniProtKB/Swiss-Prot for ICT1 Gene
Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.