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Aliases for ICOSLG Gene

Aliases for ICOSLG Gene

  • Inducible T-Cell Co-Stimulator Ligand 2 3
  • B7-Related Protein 1 2 3 4
  • B7 Homolog 2 2 3 4
  • B7RP1 3 4 6
  • B7H2 3 4 6
  • B7-Like Protein Gl50 3 4
  • B7 Homologue 2 2 3
  • B7RP-1 3 4
  • ICOSL 3 4
  • B7-H2 3 4
  • GL50 3 6
  • Transmembrane Protein B7-H2 ICOS Ligand 3
  • CD275 Antigen 4
  • ICOS Ligand 3
  • KIAA0653 4
  • ICOS-L 3
  • CD275 3
  • LICOS 3

External Ids for ICOSLG Gene

Previous HGNC Symbols for ICOSLG Gene

  • ICOSL

Previous GeneCards Identifiers for ICOSLG Gene

  • GC21M044468
  • GC21M045642
  • GC21M031016

Summaries for ICOSLG Gene

GeneCards Summary for ICOSLG Gene

ICOSLG (Inducible T-Cell Co-Stimulator Ligand) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and ICos-ICosL Pathway in T-Helper Cell. GO annotations related to this gene include receptor binding. An important paralog of this gene is LOC102723996.

UniProtKB/Swiss-Prot for ICOSLG Gene

  • Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).

Gene Wiki entry for ICOSLG Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICOSLG Gene

Genomics for ICOSLG Gene

Regulatory Elements for ICOSLG Gene

Genomic Location for ICOSLG Gene

Start:
44,222,991 bp from pter
End:
44,241,004 bp from pter
Size:
18,014 bases
Orientation:
Minus strand

Genomic View for ICOSLG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ICOSLG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICOSLG Gene

Proteins for ICOSLG Gene

  • Protein details for ICOSLG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75144-ICOSL_HUMAN
    Recommended name:
    ICOS ligand
    Protein Accession:
    O75144
    Secondary Accessions:
    • A8MUZ1
    • Q9HD18
    • Q9NRQ1

    Protein attributes for ICOSLG Gene

    Size:
    302 amino acids
    Molecular mass:
    33349 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA31628.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA31628.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown in position 300 onward for unknown reason.; Evidence={ECO:0000305};

    Alternative splice isoforms for ICOSLG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ICOSLG Gene

Proteomics data for ICOSLG Gene at MOPED

Post-translational modifications for ICOSLG Gene

  • Glycosylation at Asn70, Asn137, Asn173, Asn186, and Asn225
  • Modification sites at PhosphoSitePlus

Other Protein References for ICOSLG Gene

No data available for DME Specific Peptides for ICOSLG Gene

Domains for ICOSLG Gene

Gene Families for ICOSLG Gene

HGNC:
  • C2SET :Immunoglobulin superfamily / C2-set domain containing
  • CD :CD molecules
  • ENDOLIG :Endogenous ligands
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for ICOSLG Gene

Graphical View of Domain Structure for InterPro Entry

O75144

UniProtKB/Swiss-Prot:

ICOSL_HUMAN :
  • O75144
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with ICOSLG: view

Function for ICOSLG Gene

Molecular function for ICOSLG Gene

UniProtKB/Swiss-Prot Function: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).
UniProtKB/Swiss-Prot Induction: Constitutive expression is further enhanced by treatment with TNF in peripheral blood B-cells and monocytes, while it is decreased in dendritic cells

Gene Ontology (GO) - Molecular Function for ICOSLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 11429535
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ICOSLG: view
genes like me logo Genes that share phenotypes with ICOSLG: view

Animal Models for ICOSLG Gene

MGI Knock Outs for ICOSLG:

miRNA for ICOSLG Gene

miRTarBase miRNAs that target ICOSLG

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ICOSLG Gene

Localization for ICOSLG Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICOSLG Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ICOSLG Gene COMPARTMENTS Subcellular localization image for ICOSLG gene
Compartment Confidence
plasma membrane 4
mitochondrion 2
cytosol 1
extracellular 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ICOSLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane NAS 12145647
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ICOSLG: view

Pathways for ICOSLG Gene

genes like me logo Genes that share pathways with ICOSLG: view

Pathways by source for ICOSLG Gene

1 Qiagen pathway for ICOSLG Gene
2 Reactome pathways for ICOSLG Gene
1 GeneGo (Thomson Reuters) pathway for ICOSLG Gene

Interacting Proteins for ICOSLG Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000384432%0d%0a9606.ENSP00000319476%0d%0a9606.ENSP00000303939%0d%0a9606.ENSP00000324890%0d%0a
Selected Interacting proteins: ENSP00000384432 O75144-ICOSL_HUMAN for ICOSLG Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ICOSLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006952 defense response NAS 11983910
GO:0006972 hyperosmotic response NAS 12145647
GO:0007165 signal transduction NAS 12145647
GO:0031295 T cell costimulation TAS --
GO:0042104 positive regulation of activated T cell proliferation TAS 11429535
genes like me logo Genes that share ontologies with ICOSLG: view

Transcripts for ICOSLG Gene

Unigene Clusters for ICOSLG Gene

Inducible T-cell co-stimulator ligand:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ICOSLG Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2: - -
SP3:

Relevant External Links for ICOSLG Gene

GeneLoc Exon Structure for
ICOSLG
ECgene alternative splicing isoforms for
ICOSLG

Expression for ICOSLG Gene

mRNA expression in normal human tissues for ICOSLG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ICOSLG Gene

SOURCE GeneReport for Unigene cluster for ICOSLG Gene Hs.14155

mRNA Expression by UniProt/SwissProt for ICOSLG Gene

O75144-ICOSL_HUMAN
Tissue specificity: Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.
genes like me logo Genes that share expressions with ICOSLG: view

No data available for mRNA differential expression in normal tissues for ICOSLG Gene

Orthologs for ICOSLG Gene

This gene was present in the common ancestor of chordates.

Orthologs for ICOSLG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ICOSLG 35
  • 98.9 (n)
  • 98.34 (a)
ICOSLG 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ICOSLG 35
  • 73.06 (n)
  • 63.64 (a)
ICOSLG 36
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ICOSLG 35
  • 73.5 (n)
  • 65.27 (a)
ICOSLG 36
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Icosl 35
  • 61.58 (n)
  • 47.64 (a)
Icosl 16
Icosl 36
  • 41 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ICOSLG 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ICOSLG 36
  • 38 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Icoslg 35
  • 63.04 (n)
  • 51.36 (a)
chicken
(Gallus gallus)
Aves ICOSLG 35
  • 47.51 (n)
  • 37.8 (a)
LICOS 36
  • 32 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ICOSLG 36
  • 25 (a)
OneToOne
Species with no ortholog for ICOSLG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ICOSLG Gene

ENSEMBL:
Gene Tree for ICOSLG (if available)
TreeFam:
Gene Tree for ICOSLG (if available)

Paralogs for ICOSLG Gene

Paralogs for ICOSLG Gene

genes like me logo Genes that share paralogs with ICOSLG: view

Variants for ICOSLG Gene

Sequence variations from dbSNP and Humsavar for ICOSLG Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs15927 -- 44,227,763(-) CCGGG(A/G)CTATG intron-variant, utr-variant-3-prime
rs371970 -- 44,242,632(+) TGAGG(A/C)GGGCG upstream-variant-2KB
rs378299 -- 44,241,460(-) ATTCA(A/G)TCATT upstream-variant-2KB
rs378993 -- 44,241,635(+) AGAAA(C/T)CGAGG upstream-variant-2KB
rs390166 -- 44,242,646(+) GTGAG(C/G)CGGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ICOSLG Gene

Variant ID Type Subtype PubMed ID
esv33817 CNV Loss 17666407
nsv913887 CNV Loss 21882294
nsv913898 CNV Loss 21882294
nsv913901 CNV Loss 21882294
nsv913902 CNV Loss 21882294
nsv470906 CNV Loss 18288195
nsv913903 CNV Loss 21882294
dgv4767n71 CNV Loss 21882294
esv1737771 CNV Insertion 17803354
nsv913906 CNV Loss 21882294

Relevant External Links for ICOSLG Gene

HapMap Linkage Disequilibrium report
ICOSLG
Human Gene Mutation Database (HGMD)
ICOSLG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICOSLG Gene

Disorders for ICOSLG Gene

(3) Novoseek inferred disease relationships for ICOSLG Gene

Disease -log(P) Hits PubMed IDs
inflammation 5.28 2
necrosis 0 3
tumors 0 3

Relevant External Links for ICOSLG

Genetic Association Database (GAD)
ICOSLG
Human Genome Epidemiology (HuGE) Navigator
ICOSLG
genes like me logo Genes that share disorders with ICOSLG: view

No data available for UniProtKB/Swiss-Prot for ICOSLG Gene

Publications for ICOSLG Gene

  1. Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS. (PMID: 11007762) Yoshinaga S.K. … Coccia M.A. (Int. Immunol. 2000) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4
  3. Identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor. (PMID: 10657606) Ling V. … Collins M. (J. Immunol. 2000) 3 4
  4. Characterization of human inducible costimulator ligand expression and function. (PMID: 10779774) Aicher A. … Clark E.A. (J. Immunol. 2000) 3 4
  5. Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS. (PMID: 11023515) Wang S. … Chen L. (Blood 2000) 3 4

Products for ICOSLG Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ICOSLG
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for ICOSLG
  • Block miRNA regulation of ICOSLG using miScript Target Protectors

Sources for ICOSLG Gene

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