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Aliases for ICOSLG Gene

Aliases for ICOSLG Gene

  • Inducible T-Cell Co-Stimulator Ligand 2 3 5
  • B7-Related Protein 1 2 3 4
  • B7 Homolog 2 2 3 4
  • B7-Like Protein Gl50 3 4
  • B7 Homologue 2 2 3
  • B7RP-1 3 4
  • ICOSL 3 4
  • B7-H2 3 4
  • B7RP1 3 4
  • B7H2 3 4
  • Transmembrane Protein B7-H2 ICOS Ligand 3
  • CD275 Antigen 4
  • KIAA0653 4
  • ICOS-L 3
  • CD275 3
  • LICOS 3
  • GL50 3

External Ids for ICOSLG Gene

Previous HGNC Symbols for ICOSLG Gene

  • ICOSL

Previous GeneCards Identifiers for ICOSLG Gene

  • GC21M044468
  • GC21M045642
  • GC21M031016

Summaries for ICOSLG Gene

GeneCards Summary for ICOSLG Gene

ICOSLG (Inducible T-Cell Co-Stimulator Ligand) is a Protein Coding gene. Diseases associated with ICOSLG include inclusion body myositis and diffuse cutaneous systemic sclerosis. Among its related pathways are Immune System and Allograft rejection. GO annotations related to this gene include receptor binding. An important paralog of this gene is LOC102723996.

UniProtKB/Swiss-Prot for ICOSLG Gene

  • Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).

Gene Wiki entry for ICOSLG Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICOSLG Gene

Genomics for ICOSLG Gene

Regulatory Elements for ICOSLG Gene

Promoters for ICOSLG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ICOSLG on UCSC Golden Path with GeneCards custom track

Genomic Location for ICOSLG Gene

Chromosome:
21
Start:
44,216,971 bp from pter
End:
44,241,447 bp from pter
Size:
24,477 bases
Orientation:
Minus strand

Genomic View for ICOSLG Gene

Genes around ICOSLG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICOSLG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICOSLG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICOSLG Gene

Proteins for ICOSLG Gene

  • Protein details for ICOSLG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75144-ICOSL_HUMAN
    Recommended name:
    ICOS ligand
    Protein Accession:
    O75144
    Secondary Accessions:
    • A8MUZ1
    • Q9HD18
    • Q9NRQ1

    Protein attributes for ICOSLG Gene

    Size:
    302 amino acids
    Molecular mass:
    33349 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA31628.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA31628.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown in position 300 onward for unknown reason.; Evidence={ECO:0000305};

    Alternative splice isoforms for ICOSLG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ICOSLG Gene

Proteomics data for ICOSLG Gene at MOPED

Post-translational modifications for ICOSLG Gene

  • Glycosylation at Asn 70, Asn 102, Asn 137, Asn 173, Asn 186, and Asn 225
  • Modification sites at PhosphoSitePlus

Other Protein References for ICOSLG Gene

Antibody Products

No data available for DME Specific Peptides for ICOSLG Gene

Domains & Families for ICOSLG Gene

Protein Domains for ICOSLG Gene

Graphical View of Domain Structure for InterPro Entry

O75144

UniProtKB/Swiss-Prot:

ICOSL_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with ICOSLG: view

Function for ICOSLG Gene

Molecular function for ICOSLG Gene

UniProtKB/Swiss-Prot Function:
Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).
UniProtKB/Swiss-Prot Induction:
Constitutive expression is further enhanced by treatment with TNF in peripheral blood B-cells and monocytes, while it is decreased in dendritic cells.

Phenotypes for ICOSLG Gene

genes like me logo Genes that share phenotypes with ICOSLG: view

Animal Model Products

CRISPR Products

miRNA for ICOSLG Gene

miRTarBase miRNAs that target ICOSLG

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ICOSLG Gene

Localization for ICOSLG Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICOSLG Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ICOSLG Gene COMPARTMENTS Subcellular localization image for ICOSLG gene
Compartment Confidence
extracellular 5
plasma membrane 5
mitochondrion 3
cytosol 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for ICOSLG Gene

Pathways & Interactions for ICOSLG Gene

genes like me logo Genes that share pathways with ICOSLG: view

Pathways by source for ICOSLG Gene

Interacting Proteins for ICOSLG Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000384432%0d%0a9606.ENSP00000319476%0d%0a9606.ENSP00000303939%0d%0a9606.ENSP00000324890%0d%0a
Selected Interacting proteins: O75144-ICOSL_HUMAN ENSP00000384432 for ICOSLG Gene via I2D STRING

Gene Ontology (GO) - Biological Process for ICOSLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0007165 signal transduction NAS 12145647
GO:0031295 T cell costimulation TAS --
GO:0042104 positive regulation of activated T cell proliferation TAS 11429535
GO:0042113 B cell activation IEA --
genes like me logo Genes that share ontologies with ICOSLG: view

No data available for SIGNOR curated interactions for ICOSLG Gene

Drugs & Compounds for ICOSLG Gene

No Compound Related Data Available

Transcripts for ICOSLG Gene

Unigene Clusters for ICOSLG Gene

Inducible T-cell co-stimulator ligand:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ICOSLG Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2: - -
SP3:

Relevant External Links for ICOSLG Gene

GeneLoc Exon Structure for
ICOSLG
ECgene alternative splicing isoforms for
ICOSLG

Expression for ICOSLG Gene

mRNA expression in normal human tissues for ICOSLG Gene

Protein differential expression in normal tissues from HIPED for ICOSLG Gene

This gene is overexpressed in Urine (28.5) and Serum (26.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ICOSLG Gene



SOURCE GeneReport for Unigene cluster for ICOSLG Gene Hs.14155

mRNA Expression by UniProt/SwissProt for ICOSLG Gene

O75144-ICOSL_HUMAN
Tissue specificity: Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.
genes like me logo Genes that share expression patterns with ICOSLG: view

Protein tissue co-expression partners for ICOSLG Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ICOSLG Gene

Orthologs for ICOSLG Gene

This gene was present in the common ancestor of chordates.

Orthologs for ICOSLG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ICOSLG 35
  • 73.06 (n)
  • 63.64 (a)
ICOSLG 36
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ICOSLG 35
  • 73.5 (n)
  • 65.27 (a)
ICOSLG 36
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Icosl 35
  • 61.58 (n)
  • 47.64 (a)
Icosl 36
  • 41 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ICOSLG 35
  • 98.9 (n)
  • 98.34 (a)
ICOSLG 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Icoslg 35
  • 63.04 (n)
  • 51.36 (a)
oppossum
(Monodelphis domestica)
Mammalia ICOSLG 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ICOSLG 36
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves ICOSLG 35
  • 47.51 (n)
  • 37.8 (a)
LICOS 36
  • 32 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ICOSLG 36
  • 25 (a)
OneToOne
Species with no ortholog for ICOSLG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ICOSLG Gene

ENSEMBL:
Gene Tree for ICOSLG (if available)
TreeFam:
Gene Tree for ICOSLG (if available)

Paralogs for ICOSLG Gene

Paralogs for ICOSLG Gene

genes like me logo Genes that share paralogs with ICOSLG: view

Variants for ICOSLG Gene

Sequence variations from dbSNP and Humsavar for ICOSLG Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs11558819 - 44,236,891(-) TGAGC(A/G)TTGAG intron-variant, reference, missense
rs15927 -- 44,227,763(-) CCGGG(A/G)CTATG intron-variant, utr-variant-3-prime
rs390166 -- 44,242,646(+) GTGAG(C/G)CGGGC upstream-variant-2KB
rs390167 -- 44,242,647(+) TGAGC(A/C)GGGCG upstream-variant-2KB
rs419600 -- 44,242,631(+) GTGAG(C/G)AGGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ICOSLG Gene

Variant ID Type Subtype PubMed ID
esv33817 CNV Loss 17666407
nsv913887 CNV Loss 21882294
nsv913898 CNV Loss 21882294
nsv913901 CNV Loss 21882294
nsv913902 CNV Loss 21882294
nsv470906 CNV Loss 18288195
nsv913903 CNV Loss 21882294
dgv4767n71 CNV Loss 21882294
esv1737771 CNV Insertion 17803354
nsv913906 CNV Loss 21882294

Variation tolerance for ICOSLG Gene

Residual Variation Intolerance Score: 60% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.44; 85.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ICOSLG Gene

HapMap Linkage Disequilibrium report
ICOSLG
Human Gene Mutation Database (HGMD)
ICOSLG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICOSLG Gene

Disorders for ICOSLG Gene

MalaCards: The human disease database

(2) MalaCards diseases for ICOSLG Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
inclusion body myositis
  • nonaka myopathy
diffuse cutaneous systemic sclerosis
  • diffuse scleroderma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ICOSLG

Genetic Association Database (GAD)
ICOSLG
Human Genome Epidemiology (HuGE) Navigator
ICOSLG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ICOSLG
genes like me logo Genes that share disorders with ICOSLG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ICOSLG Gene

Publications for ICOSLG Gene

  1. Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS. (PMID: 11007762) Yoshinaga S.K. … Coccia M.A. (Int. Immunol. 2000) 2 3 4 23 67
  2. Impact of female cigarette smoking on circulating B cells in vivo: the suppressed ICOSLG, TCF3, and VCAM1 gene functional network may inhibit normal cell function. (PMID: 20217071) Pan F. … Deng H.W. (Immunogenetics 2010) 3 23
  3. [Expression of B7-related protein-1 on human coronary artery endothelial cells and its clinical significance]. (PMID: 19726311) Xu L. … Qiu J. (Nan Fang Yi Ke Da Xue Xue Bao 2009) 3 23
  4. [Expression of ICOSL on human coronary artery endothelial cells and its being interferentialed by ox-LDL]. (PMID: 19737469) Xu L. … Qiu J. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2009) 3 23
  5. Renal tubular epithelial cells modulate T-cell responses via ICOS-L and B7-H1. (PMID: 16221208) de Haij S. … van Kooten C. (Kidney Int. 2005) 3 23

Products for ICOSLG Gene

Sources for ICOSLG Gene

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