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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ICOSLG Gene

protein-coding   GIFtS: 63
GCID: GC21M045642

Inducible T-Cell Co-Stimulator Ligand


(Previous symbol: ICOSL)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Inducible T-Cell Co-Stimulator Ligand1 2     B7-Like Protein Gl502 3
ICOSL1 2 3     GL502 5
B7 Homolog 21 2 3     CD2752
B7-Related Protein 11 2 3     ICOS-L2
B7H22 3 5     LICOS2
B7RP12 3 5     ICOS Ligand2
B7 Homologue 21 2     Transmembrane Protein B7-H2 ICOS Ligand2
B7-H22 3     KIAA06533
B7RP-12 3     CD275 Antigen3

External Ids:    HGNC: 170871   Entrez Gene: 233082   Ensembl: ENSG000001602237   OMIM: 6057175   UniProtKB: O751443   

Export aliases for ICOSLG gene to outside databases

Previous GC identifers: GC21M044468 GC21M031016


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ICOSLG Gene: 
ICOSLG (inducible T-cell co-stimulator ligand) is a protein-coding gene. Diseases associated with ICOSLG include inclusion body myositis, and myositis, and among its related super-pathways are Immune System and Immune response ICOS pathway in T-helper cell. GO annotations related to this gene include receptor binding. An important paralog of this gene is VTCN1.

UniProtKB/Swiss-Prot: ICOSL_HUMAN, O75144
Function: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell
proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells.
Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in
modulating the secondary immune response by co-stimulating memory T-cell function (By similarity)

Gene Wiki entry for ICOSLG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000021.8  NT_011515.12  NC_018932.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ICOSLG gene promoter:
         SRF   Pax-5   Sp1   ATF-2   SRF (504 AA)   Pax-2   Pax-2a   CREB   CRE-BP1   deltaCREB   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ICOSLG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ICOSLG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3

ICOSLG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ICOSLG gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M045642:  view genomic region     (about GC identifiers)

Start:
45,642,874 bp from pter      End:
45,660,849 bp from pter
Size:
17,976 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ICOSL_HUMAN, O75144 (See protein sequence)
Recommended Name: ICOS ligand precursor  
Size: 302 amino acids; 33349 Da
Subcellular location: Membrane; Single-pass type I membrane protein (By similarity)
Sequence caution: Sequence=BAA31628.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAA31628.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown in position 300
onward for unknown reason;
Secondary accessions: Q9HD18 Q9NRQ1
Alternative splicing: 2 isoforms:  O75144-1   O75144-2   

Explore the universe of human proteins at neXtProt for ICOSLG: NX_O75144

Explore proteomics data for ICOSLG at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75144

  • ICOSLG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ICOSLG Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001269979.1  NP_001269980.1  NP_001269981.1  NP_056074.1  

    ENSEMBL proteins: 
     ENSP00000339477   ENSP00000384432   ENSP00000383230   ENSP00000383228  
    Reactome Protein details: O75144
    Human Recombinant Protein Products for ICOSLG: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ICOSLG (B7-H2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ICOSLG
    OriGene Protein Over-expression Lysate for ICOSLG
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    Novus Biologicals ICOSLG Protein
    Novus Biologicals ICOSLG Lysate
    Sino Biological Recombinant Protein for ICOSLG
    Sino Biological Cell Lysate for ICOSLG 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ICOSLG 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IEA--
    GO:0009897external side of plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane NAS12145647

    ICOSLG for ontologies           About GeneDecksing



    ICOSLG Antibody Products: 
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    Novus Biologicals ICOSLG Antibodies
    Abcam antibodies for ICOSLG
    Cloud-Clone Corp. Antibodies for ICOSLG 
    ThermoFisher Antibodies for ICOSLG
    LSBio Antibodies in human, mouse, rat for ICOSLG 

    Assay Products for ICOSLG: 
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    Cloud-Clone Corp. ELISAs for ICOSLG 
    Cloud-Clone Corp. CLIAs for ICOSLG


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry O75144

    ProtoNet protein and cluster: O75144

    2 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: ICOSL_HUMAN, O75144
    Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    ICOSLG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ICOSL_HUMAN, O75144
    Function: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell
    proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells.
    Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in
    modulating the secondary immune response by co-stimulating memory T-cell function (By similarity)
    Induction: Constitutive expression is further enhanced by treatment with TNF in peripheral blood B-cells and
    monocytes, while it is decreased in dendritic cells

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS11429535
    GO:0005515protein binding ----
         
    ICOSLG for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Icosl):
     cellular  hematopoietic system  homeostasis/metabolism  immune system 

    ICOSLG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ICOSLG: Icosltm1Cdon Icosltm1Mak Icosltm1Kplm

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ICOSLG 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ICOSLG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ICOSLG 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ICOSLG 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ICOSLG
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ICOSLG:
    hsa-miR-339-5p
    SwitchGear 3'UTR luciferase reporter plasmidICOSLG 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of ICOSLG 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICOSLG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ICOSLG About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Adaptive Immune System0.56
    2Immune response ICOS pathway in T-helper cell
    Immune response ICOS pathway in T-helper cell0.91
    3Allograft rejection
    Intestinal immune network for IgA production0.42
    4CD28 co-stimulation
    Costimulation by the CD28 family0.41
    5Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ICOSLG
        Immune response ICOS pathway in T-helper cell


    1 GeneGo (Thomson Reuters) Pathway for ICOSLG
        Immune response ICOS pathway in T-helper cell


    3        Reactome Pathways for ICOSLG
        Costimulation by the CD28 family
    Adaptive Immune System
    Immune System


    2         Kegg Pathways  (Kegg details for ICOSLG):
        Cell adhesion molecules (CAMs)
    Intestinal immune network for IgA production


    ICOSLG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ICOSLG

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ICOSLG (O751443 ENSP000003844324) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICOSQ9Y6W83, ENSP000003194764I2D: score=4 STRING: ENSP00000319476
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response NAS11983910
    GO:0006972hyperosmotic response NAS12145647
    GO:0007165signal transduction NAS12145647
    GO:0031295T cell costimulation TAS--
    GO:0042104positive regulation of activated T cell proliferation TAS11429535

    ICOSLG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ICOSLG (ICOSL)

    Search CenterWatch for drugs/clinical trials and news about ICOSLG / ICOSL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ICOSLG gene (4 alternative transcripts): 
    NM_001283050.1  NM_001283051.1  NM_001283052.1  NM_015259.5  

    Unigene Cluster for ICOSLG:

    Inducible T-cell co-stimulator ligand
    Hs.14155  [show with all ESTs]
    Unigene Representative Sequence: NM_015259
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344330 ENST00000407780 ENST00000400379(uc002zee.3 uc011afc.2 uc010gpp.1)
    ENST00000400377(uc002zef.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ICOSLG
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ICOSLG:
    hsa-miR-339-5p
    SwitchGear 3'UTR luciferase reporter plasmidICOSLG 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ICOSLG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ICOSLG
    Clone
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    GenScript: all cDNA clones in your preferred vector: ICOSLG (NM_015259)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ICOSLG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICOSLG
    Sirion Biotech Customized lentivirus for stable overexpression of ICOSLG 
                         Customized lentivirus expression plasmids for stable overexpression of ICOSLG 
    Primer
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    OriGene qPCR primer pairs and template standards for ICOSLG
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ICOSLG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ICOSLG

    Additional mRNA sequence: 

    AF199028.1 AF216749.1 AF289028.1 AK090492.1 AK290192.1 AK294031.1 AK311496.1 AK314369.1 
    AK316143.1 AK316176.1 AL355690.1 BC064637.1 

    6 DOTS entries:

    DT.121141597  DT.307580  DT.100750231  DT.311987  DT.100019380  DT.92420158 

    24/99 AceView cDNA sequences (see all 99):

    BX281778 BI488470 AA482045 BF221467 AF216749 BM923293 AA778249 AI144115 
    AI421115 D45643 AA476212 CK299365 AA733043 CR595366 NM_015259 AA781960 
    AF199028 AA812918 BM543561 AI818208 AW819666 BQ005303 BU193522 AW025733 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ICOSLG    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
    SP1:                                                  -               
    SP2:                          -                       -               
    SP3:                                                                  


    ECgene alternative splicing isoforms for ICOSLG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ICOSLG expression in normal human tissues (normalized intensities)      ICOSLG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGCATTAG
    ICOSLG Expression
    About this image


    ICOSLG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Epithelium (Reproductive System)    fully expand to see all 4 entries
             cervix, uterine ; squamous epithelial cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See ICOSLG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ICOSLG

    SOURCE GeneReport for Unigene cluster: Hs.14155

    UniProtKB/Swiss-Prot: ICOSL_HUMAN, O75144
    Tissue specificity: Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal
    muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while
    isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic
    cells

        SABiosciences Expression via Pathway-Focused PCR Array including ICOSLG: 
              T-cell & B-cell Activation in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ICOSLG
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICOSLG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ICOSLG gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Icosl1 , 5 icos ligand1, 5 62.27(n)1
    47.92(a)1
      10 (39.72 cM)5
    507231  NM_015790.31  NP_056605.11 
     780693685 
    chicken
    (Gallus gallus)
    Aves ICOSLG1 inducible T-cell co-stimulator ligand 46.81(n)
    35.74(a)
      395968  NM_205084.1  NP_990415.1 
    lizard
    (Anolis carolinensis)
    Reptilia ICOSLG6
    inducible T-cell co-stimulator ligand
    28(a)
    1 ↔ 1
    3(136293340-136315406)


    ENSEMBL Gene Tree for ICOSLG (if available)
    TreeFam Gene Tree for ICOSLG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ICOSLG gene
    VTCN12  HHLA22  CD2762  

    ICOSLG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/454 SNPs in ICOSLG are shown (see all 454)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs48188901,2
    C,F,A,H--45646256(+) CTTGAC/ATGGAG 1 -- ds500121Minor allele frequency- A:0.23NS EA NA WA 2348
    rs1396363511,2
    --45646317(+) CTGGCA/GAGAGT 1 -- ds50010--------
    rs1497616131,2
    --45646345(+) AGACCC/GGCAAG 1 -- ds50010--------
    rs1457119001,2
    --45646497(+) AACAGC/TATCTG 1 -- ds50010--------
    rs1891906731,2
    --45646514(+) CCACCC/TGCTGA 1 -- ds50010--------
    rs754738221,2
    C,F--45646537(+) GCCCCC/AAGCTG 1 -- ds50011Minor allele frequency- A:0.19WA 118
    rs1922330261,2
    --45646595(+) ACGGAA/TCAGCC 1 -- ds50010--------
    rs65183521,2
    C,F,A,H--45646698(+) CCACCG/AAAGCC 1 -- ds500124Minor allele frequency- A:0.26NS EA WA NA CSA 2351
    rs1846697361,2
    --45646820(+) TGTTGG/TGCTGA 1 -- ut310--------
    rs1884965441,2
    C--45646862(+) AATGCC/TGACGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ICOSLG (45642874 - 45660849 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ICOSLG:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1737771CNV Insertion17803354
    nsv913903CNV Loss21882294
    nsv913902CNV Loss21882294
    nsv913887CNV Loss21882294
    nsv470906CNV Loss18288195
    nsv913901CNV Loss21882294
    esv33817CNV Loss17666407
    dgv4767n71CNV Loss21882294
    nsv913906CNV Loss21882294
    nsv913898CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605717    OMIM disorders: --

    20/24 diseases for ICOSLG (see all 24):    About MalaCards
    inclusion body myositis    myositis    ankylosing spondylitis    tonsillitis
    lupus nephritis    spondylitis    crohn's disease    nephritis
    celiac disease    narcolepsy    cholera    acute myeloid leukemia
    systemic lupus erythematosus    type 1 diabetes    lupus erythematosus    myeloid leukemia
    neuropathy    asthma    rheumatoid arthritis    arthritis


    ICOSLG for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for ICOSLG gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 5.28 2 15047591 (2)
    necrosis 0 3 11007762 (1), 14603470 (1), 16221208 (1)
    tumors 0 3 11007762 (1), 14603470 (1), 16221208 (1)

    Genetic Association Database (GAD): ICOSLG
    Human Genome Epidemiology (HuGE) Navigator: ICOSLG (14 documents)

    Export disorders for ICOSLG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ICOSLG gene, integrated from 9 sources (see all 71):
    (articles sorted by number of sources associating them with ICOSLG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS. (PubMed id 11007762)1, 2, 3, 9 Yoshinaga S.K.... Coccia M.A. (2000)
    2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (1998)
    3. Multiple common variants for celiac disease influenci ng immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (2010)
    4. Analysis of 39 Crohn's disease risk loci in Swedish i nflammatory bowel disease patients. (PubMed id 19760754)1, 4 TAPrkvist L....Pettersson S. (2010)
    5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (2010)
    6. Comparative genetic analysis of inflammatory bowel di sease and type 1 diabetes implicates multiple loci with opposite effects. (PubMed id 20176734)1, 4 Wang K....Hakonarson H. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. (PubMed id 18587394)1, 4 Barrett J.C....Daly M.J. (2008)
    9. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23308 HGNC: 17087 AceView: ICOSL Ensembl:ENSG00000160223 euGenes: HUgn23308
    ECgene: ICOSLG Kegg: 23308 H-InvDB: ICOSLG

    (According to HUGE)
    About This Section
    HUGE: KIAA0653

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ICOSLG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ICOSLG gene:
    Search GeneIP for patents involving ICOSLG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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