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ICOSLG Gene

protein-coding GIFtS: 60

GC21M044468

inducible T-cell co-stimulator ligand
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: ICOSL)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
B7-H2 ^¹, ², ³
B7H2 ^¹, ², ³
B7RP-1 ^¹, ², ³
B7RP1 ^¹, ², ³
CD275 ^¹, ²
GL50 ^¹, ²
ICOS-L ^¹, ²
ICOSL ^², ³
KIAA0653 ^¹, ², ³
LICOS ^²
OTTHUMP00000109524 ^²

Descriptions
B7 homolog 2 ^³
B7-like protein ^²
B7-like protein Gl50 ^³
B7-related protein 1 ^³
CD275 antigen ^³
inducible T-cell co-stimulator ligand ^²
transmembrane protein B7-H2 ICOS ligand ^²

External Ids
HGNC: 17087¹
Entrez Gene: 23308²
UniProtKB: O75144³
Ensembl: ENSG00000160223⁷

Search outside databases for aliases for ICOSLG gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: ICOSL_HUMAN, O75144

Function: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal

for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and

differentiation into plasma cells. Could play an important role in mediating local tissue

responses to inflammatory conditions, as well as in modulating the secondary immune response by

co-stimulating memory T-cell function (By similarity)

Gene Wiki entry for ICOSLG

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ICOSLG gene

Entrez Gene cytogenetic band: 21q22.3 Ensembl cytogenetic band: 21q22.3 HGNC cytogenetic band: 21q22.3

ICOSLG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 21 GeneLoc Exon Structure

GeneLoc location for GC21M044468: (about GC identifiers)

Start:	44,467,302 bp from pter
End:	44,485,277 bp from pter
Size:	17,976 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000021.7 NT_011515.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ICOSL_HUMAN, O75144 (See protein sequence)

Recommended Name: ICOS ligand precursor

Size: 302 amino acids; 33349 Da

Subcellular location: Membrane; Single-pass type I membrane protein (By similarity)

Sequence caution: Sequence=BAA31628.1; Type=Erroneous initiation; Note=Translation N-terminally

shortened; Sequence=BAA31628.1; Type=Miscellaneous discrepancy; Note=The sequence differs from

that shown in position 300 onward for unknown reason;

Secondary accessions: Q9HD18 Q9NRQ1

Alternative splicing: 2 isoforms: O75144-1 O75144-2 (Additional isoforms seem to exist)

REFSEQ proteins: NP_056074.1

ENSEMBL proteins:

ENSP00000383228 ENSP00000383227 ENSP00000383229 ENSP00000339477 ENSP00000383230 ENSP00000384432

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for ICOSLG (B7-H2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ICOS Ligand)
	Human Recombinant Proteins from Abnova (ICOSLG)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	NAS	12145647

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Antibodies for ICOSLG:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ICOSLG
	R&D Systems Antibodies for ICOSLG (B7-H2)
	Antibodies from Abcam (ICOS Ligand), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ICOSLG)
	Novus Biologicals Antibodies for ICOSLG

Assays for ICOSLG:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O75144

ProtoNet protein and cluster: O75144

2 Blocks protein families:

IPB003599 Immunoglobulin subtype

IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: ICOSL_HUMAN, O75144

Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ICOSLG)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ICOSLG)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015259

Applied Biosystems Silencer® siRNAs for ICOSLG

Sigma-Aldrich siRNA for ICOSLG

Sigma-Aldrich shRNA Panels and shRNA for ICOSLG

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_015259
Myc/DDK tagged cDNA clone in CMV expression vector: NM_015259
untagged cDNA clone in CMV expression vector: NM_015259

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_015259

UniProtKB/Swiss-Prot: ICOSL_HUMAN, O75144

Function: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal

for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and

differentiation into plasma cells. Could play an important role in mediating local tissue

responses to inflammatory conditions, as well as in modulating the secondary immune response by

co-stimulating memory T-cell function (By similarity)

Induction: Constitutive expression is further enhanced by treatment with TNF-alpha in peripheral

blood B-cells and monocytes, while it is decreased in dendritic cells

3 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Icosl):

hematopoietic system

homeostasis/metabolism

immune system

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	TAS	11429535

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for ICOSLG (Your Favorite Gene powered by Ingenuity)

iCOS-iCOSL Signaling in T Helper Cells

GeneDecks ICOSLG for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ICOSLG

5/16 Interacting proteins for ICOSLG (ENSP00000339477³) via UniProtKB, MINT, and/or STRING (see all 16 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ICOS	ENSP00000319476³	STRING (score=.999)
CD28	ENSP00000324890³	STRING (score=.991)
CTLA4	ENSP00000303939³	STRING (score=.926)
IL10	ENSP00000356066³	STRING (score=.891)
BTLA	ENSP00000333919³	STRING (score=.868)

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006952	defense response	NAS	11983910
GO:0006955	immune response	IEA	--
GO:0006972	hyperosmotic response	NAS	12145647
GO:0007165	signal transduction	NAS	12145647
GO:0042104	positive regulation of activated T cell proliferation	TAS	11429535

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ICOSLG

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ICOSLG)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ICOSLG)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015259

Sigma-Aldrich siRNA for ICOSLG

Sigma-Aldrich shRNA Panels and shRNA for ICOSLG

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_015259

REFSEQ mRNAs for ICOSLG gene:

NM_015259.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_015259

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015259
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_015259
                                 untagged cDNA clone in CMV expression vector: NM_015259

Additional cDNA sequence:

AF199028.1 AF216749.1 AF289028.1 AK090492.1 AK290192.1 AK294031.1 AK311496.1 AK314369.1

AK316143.1 AK316176.1 AL355690.1 BC064637.1 CR595366.1

6 DOTS entries:

DT.121141597 DT.307580 DT.100750231 DT.311987 DT.100019380 DT.92420158

24/99 AceView cDNA sequences (see all 99 ):

BM923293 CR595366 AA476212 AF199028 NM_015259 BX281778 BI488470 AA733043

AA781960 AI144115 AI421115 D45643 AF216749 BM543561 CK299365 AA812918

BF221467 AA778249 AA482045 BQ005303 AI383891 AI359801 AI361552 AB014553

highest scoring ESTs for ICOSLG:

AB014553 AF199028 AF216749 AF289028 AK090492 AL560774 BC064637 BI488470 BM543561 BM923293

Unigene Cluster for ICOSLG:

Inducible T-cell co-stimulator ligand

Hs.14155 [show with all ESTs]

Unigene Representative Sequence: NM_015259

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ICOSLG

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b
SP1:																	-
SP2:									-								-
SP3:

About this scheme

ECgene alternative splicing isoforms for ICOSLG

6 Ensembl transcripts including schematic representations:

ENST00000400377 ENST00000400376 ENST00000400378 ENST00000344330 ENST00000400379 ENST00000407780

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ICOSLG expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ICOSLG

¹ / ² / ³

12 probe-sets matching ICOSLG gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
31803_at²^{, 3}	U95-A	1	1.00	1.00	0.09	0.66	AB014553	0.80	1.00	0.91	1
57680_at²^{, 3}	U95-C	1	1.00	1.00	0.82	1.35	AA778249	0.40	1.00	0.76	1
228976_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA778249	0.40	1.00	0.76	1
211198_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF289028	0.80	1.00	0.91	1
213450_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI659611	0.60	1.00	0.82	1
211197_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL355690	0.40	1.00	0.76	1
211199_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF199028	0.80	1.00	0.91	1
228976_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211198_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
213450_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211197_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211199_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ICOSLG for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAAGCATTAG

SOURCE GeneReport for Unigene cluster: Hs.14155
Expression variation in blood from EXPOLDB for ICOSLG
UniProtKB/Swiss-Prot: ICOSL_HUMAN, O75144
Tissue specificity: Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas,
placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes,
spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and
spleen. Expressed on activated monocytes and dendritic cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ICOSLG gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ICOSLG¹	--	inducible T-cell co-stimulator ligand	70.47(n) 61.03(a)	487793 XM_544918.2 XP_544918.2
chimpanzee (Pan troglodytes)	ICOSLG¹	--	inducible T-cell co-stimulator ligand	98.89(n) 98.33(a)	474132 XM_531578.2 XP_531578.2
cow (Bos taurus)	ICOSLG¹	--	inducible T-cell co-stimulator ligand	73.11(n) 63.73(a)	507857 XM_584543.3 XP_584543.2
rat (Rattus norvegicus)	Icoslg¹	--	inducible T-cell co-stimulator ligand	62.7(n) 51.26(a)	499415 XM_574731.2 XP_574731.2
mouse (Mus musculus)	Icosl^{1, 5}	10⁵	icos ligand^{1, 5}	62.27(n)¹ 47.92(a)¹	50723¹ NM_015790.3¹ NP_056605.1¹ AC015891⁵ AF199027⁵ (see all 20)

About this table Species with no ortholog for ICOSLG

ENSEMBL Gene Tree for ICOSLG

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/123 NCBI SNPs in ICOSLG are shown (see all 123 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 70)

AB	SNP ID	Valid	Chr 21 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4818890^1,2	A,C,F,H	44470684(+)	`CTTGAC/ATGGAG`	1	--	ng5¹		4		EU EA WA	402
	rs4819388^1,2	A,C,F,H	44471849(+)	`AAGGCC/TCAGGT`	1	--	ut3¹		4		EU EA WA	416
	rs6518352^1,2	A,C,F,H	44471126(+)	`CCACCG/AAAGCC`	1	--	ng5¹		1		WA	120
	rs15927^1,2	A,C,F,H	44472074(-)	`CCGGGG/ACTATG`	1	--	ut3¹		6		MN EU EA WA	784
	rs378299^1,2	A,C,F,H	44485771(-)	`attcaA/Gtcatt`	1	--	ng3¹		4		EU EA WA	420
	rs11701509^1,2	C,H	44481249(+)	`GGCAGT/AGAAAC`	1	L/H	mis¹ ese³		4		EU EA WA	420
	rs8129253^1,2	A,C	44486664(+)	`CGCGGA/CGTGCA`	1	--	ng3¹		0	--	--	--	--
	rs11558819^1,2	C,F	44481202(-)	`TGAGCG/ATTGAG`	1	I/V	mis¹		4		EU EA WA	420
	rs3804033^1,2	H	44472916(+)	`ACAGAC/GGCCGT`	1	--	ut3¹		2		EA EU	1230
	rs3746961^1,2	H	44471418(+)	`CCGTGC/TCCTCA`	1	--	ut3¹		4		EU EA WA	416

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HapMap Linkage Disequilibrium images for ICOSLG (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 605717

3 Novoseek disease relationships for ICOSLG gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	10.61	2	15047591 (2)
necrosis	2.62	3	11007762 (1), 14603470 (1), 16221208 (1)
tumors	0.00	3	11007762 (1), 14603470 (1), 16221208 (1)

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Human Genome Epidemiology Navigator: ICOSLG (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/47 PubMed articles for ICOSLG gene (see all 47 ):

Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS. (PubMed id 11007762)^{1, 2, 3, 4} Yoshinaga S.K....Coccia M.A. (2000)
Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)^{2, 3, 4} Ishikawa K....Ohara O. (1998)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{3, 4} Liu T.... Smith R.D. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS. (PubMed id 11023515)^{3, 4} Wang S.... Chen L. (2000)
Characterization of human inducible costimulator ligand expression and function. (PubMed id 10779774)^{3, 4} Aicher A.... Clark E.A. (2000)
Identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor. (PubMed id 10657606)^{3, 4} Ling V.... Collins M. (2000)
Expression of the B7-related molecule ICOSL by human glioma cells in vitro and in vivo. (PubMed id 14603470)^{1, 3} Schreiner B....Wiendl H. (2003)
Renal tubular epithelial cells modulate T-cell responses via ICOS-L and B7-H1. (PubMed id 16221208)^{1, 3} de Haij S....van Kooten C. (2005)
Differential expression of inducible costimulator-ligand splice variants: lymphoid regulation of mouse GL50-B and human GL50 molecules. (PubMed id 11390480)^{1, 3} Ling V....Collins M. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 23308	HGNC: 17087	AceView: ICOSL	Ensembl:ENSG00000160223	euGenes: HUgn23308
ECgene: ICOSLG	H-InvDB: ICOSLG

(According to HUGE)
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HUGE: KIAA0653

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ICOSLG
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ICOSLG:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ICOSLG-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ICOSLG		Antibodies for ICOSLG
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ICOSLG		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ICOSLG)
	Antibodies (ICOSLG)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (ICOS Ligand)
	Antibodies (ICOS Ligand)

Search OriGene for ICOSLG

Search Tocris compounds for ICOSLG

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ICOSLG

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ICOSLG Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for ICOSLG

Summaries
for ICOSLG

Genomic Location
for ICOSLG

Proteins
for ICOSLG

Protein Domains/
Families
for ICOSLG

Gene Function
for ICOSLG

Pathways & Interactions
for ICOSLG

Drugs & Compounds
for ICOSLG

Transcripts
for ICOSLG

Expression
for ICOSLG

Orthologs
for ICOSLG

Paralogs
for ICOSLG

SNPs/Variants
for ICOSLG

Disorders & Mutations
for ICOSLG

Medical News
for ICOSLG

Publications
for ICOSLG

Search for ICOSLG

Genome Databases showing ICOSLG

Other Databases showing ICOSLG

Specialized Databases showing ICOSLG

Licensable Technologies
for ICOSLG

Services
for ICOSLG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ICOSLG Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor ICOSLG

Summariesfor ICOSLG

Genomic Locationfor ICOSLG

Proteinsfor ICOSLG

Protein Domains/Familiesfor ICOSLG

Gene Functionfor ICOSLG

Pathways & Interactionsfor ICOSLG

Drugs & Compoundsfor ICOSLG

Transcriptsfor ICOSLG

Expression for ICOSLG

Orthologsfor ICOSLG

Paralogsfor ICOSLG

SNPs/Variantsfor ICOSLG

Disorders & Mutationsfor ICOSLG

Medical Newsfor ICOSLG

Publicationsfor ICOSLG

Search for ICOSLG

Genome Databases showing ICOSLG

Other Databases showing ICOSLG

Specialized Databases showing ICOSLG

Licensable Technologiesfor ICOSLG

Servicesfor ICOSLG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ICOSLG

Summaries
for ICOSLG

Genomic Location
for ICOSLG

Proteins
for ICOSLG

Protein Domains/
Families
for ICOSLG

Gene Function
for ICOSLG

Pathways & Interactions
for ICOSLG

Drugs & Compounds
for ICOSLG

Transcripts
for ICOSLG

Expression
for ICOSLG

Orthologs
for ICOSLG

Paralogs
for ICOSLG

SNPs/Variants
for ICOSLG

Disorders & Mutations
for ICOSLG

Medical News
for ICOSLG

Publications
for ICOSLG

Licensable Technologies
for ICOSLG

Services
for ICOSLG