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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ICOSLG Gene

protein-coding   GIFtS: 63
GCID: GC21M045642

inducible T-cell co-stimulator ligand


(Previous symbol: ICOSL)
 Explore 22 diseases affiliated with
ICOSLG via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ICOSLG    

Aliases
for ICOSLG gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Inducible T-Cell Co-Stimulator Ligand1 2     KIAA06531 3
B7H21 2 3 5     B7 Homolog 22 3
B7RP11 2 3 5     B7-Like Protein Gl502 3
B7-H21 2 3     B7-Related Protein 12 3
B7RP-11 2 3     LICOS2
ICOSL1 2 3     B7 Homologue 22
GL501 2 5     ICOS Ligand2
CD2751 2     Transmembrane Protein B7-H2 ICOS Ligand2
ICOS-L1 2     CD275 Antigen3

External Ids:    HGNC: 170871   Entrez Gene: 233082   Ensembl: ENSG000001602237   OMIM: 6057175   UniProtKB: O751443   

Export aliases for ICOSLG gene to outside databases

Previous GC identifers: GC21M044468 GC21M031016


Summaries
for ICOSLG gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ICOSL_HUMAN, O75144
Function: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell
proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could
play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the
secondary immune response by co-stimulating memory T-cell function (By similarity)

Gene Wiki entry for ICOSLG


Genomic Views
for ICOSLG gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011515.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ICOSLG gene promoter:
         SRF   Pax-5   Sp1   ATF-2   SRF (504 AA)   Pax-2   Pax-2a   CREB   CRE-BP1   deltaCREB   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ICOSLG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ICOSLG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3

ICOSLG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ICOSLG gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M045642:  view genomic region     (about GC identifiers)

Start:
 45,642,874 bp from pter      End:
 45,660,849 bp from pter
Size:
 17,976 bases      Orientation:
 minus strand

Proteins
for ICOSLG gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ICOSL_HUMAN, O75144 (See protein sequence)
Recommended Name: ICOS ligand precursor  
Size: 302 amino acids; 33349 Da
Subcellular location: Membrane; Single-pass type I membrane protein (By similarity)
Sequence caution: Sequence=BAA31628.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAA31628.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown in position 300 onward
for unknown reason;
Secondary accessions: Q9HD18 Q9NRQ1
Alternative splicing: 2 isoforms:  O75144-1   O75144-2   

Explore the universe of human proteins at neXtProt for ICOSLG: NX_O75144

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75144

    • ICOSLG Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_056074.1  
    ENSEMBL proteins: 
     ENSP00000339477   ENSP00000384432   ENSP00000383230   ENSP00000383228  
    Reactome Protein details: O75144
    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for ICOSLG (B7-H2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ICOSLG
    OriGene Protein Over-expression Lysate: ICOSLG
    OriGene Custom Protein Services for ICOSLG 
    GenScript Custom Purified and Recombinant Proteins Services for ICOSLG
    Novus Biologicals ICOSLG Protein
    Novus Biologicals ICOSLG Lysate
    Sino Biological Recombinant Protein for ICOSLG
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ICOSLG

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IEA--
    GO:0009897external side of plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane NAS12145647


    ICOSLG for ontologies           About GeneDecksing



    ICOSLG Antibody Products: 
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    Assay Products for ICOSLG: 
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    Uscn ELISAs and CLIAs for ICOSLG

    Protein Domains /
    Families
    for ICOSLG gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ICOSLG for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry O75144

    ProtoNet protein and cluster: O75144

    2 Blocks protein families:
    IPB003599 Immunoglobulin subtype
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: ICOSL_HUMAN, O75144
    Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Function
    for ICOSLG gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ICOSL_HUMAN, O75144
    Function: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell
    proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could
    play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the
    secondary immune response by co-stimulating memory T-cell function (By similarity)
    Induction: Constitutive expression is further enhanced by treatment with TNF in peripheral blood B-cells and monocytes,
    while it is decreased in dendritic cells

    miRNA
    Products:            		 OriGene 3'-UTR Clone: ICOSLG
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ICOSLG
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ICOSLG:
    hsa-miR-339-5p
    SwitchGear 3'UTR luciferase reporter plasmid: ICOSLG 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ICOSLG (see all 4)
    OriGene shRNA RFP: ICOSLG
    OriGene siRNA: ICOSLG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ICOSLG

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ICOSLG

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ICOSLG (see all 2)
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    Sino Biological Human cDNA Clone for ICOSLG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ICOSLG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICOSLG 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ICOSLG
    Search LifeMap BioReagents cell lines for ICOSLG

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICOSLG

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS11429535
    GO:0005515protein binding ----


    ICOSLG for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for ICOSLG: Icosltm1Cdon Icosltm1Mak Icosltm1Kplm
         4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Icosl):
     cellular  hematopoietic system  homeostasis/metabolism  immune system 

    ICOSLG for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ICOSLG gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    2Immune response_ICOS pathway in T-helper cell
    		Immune response_ICOS pathway in T-helper cell1.00
    		Immune response ICOS pathway in T-helper cell0.91
    3Cell adhesion molecules (CAMs)
    		Cell adhesion molecules (CAMs)1.00
    4CD28 co-stimulation
    		Costimulation by the CD28 family0.41
    5Allograft rejection
    		Intestinal immune network for IgA production0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ICOSLG
        Immune response ICOS pathway in T-helper cell


    1 GeneGo (Thomson Reuters) Pathway for ICOSLG
        Immune response ICOS pathway in T-helper cell

    3        Reactome Pathways for ICOSLG
        Costimulation by the CD28 family
    Adaptive Immune System
    Immune System


    2         Kegg Pathways  (Kegg details for ICOSLG):
        Cell adhesion molecules (CAMs)
    Intestinal immune network for IgA production


    ICOSLG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ICOSLG

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ICOSLG (O751443 ENSP000003844324) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICOSQ9Y6W83, ENSP000003194764I2D: score=4 STRING: ENSP00000319476
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response NAS11983910
    GO:0006972hyperosmotic response NAS12145647
    GO:0007165signal transduction NAS12145647
    GO:0031295T cell costimulation TAS--
    GO:0042104positive regulation of activated T cell proliferation TAS11429535


    ICOSLG for ontologies           About GeneDecksing



    Drugs & Compounds
    for ICOSLG gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ICOSLG
    Search CenterWatch for drugs/clinical trials and news about ICOSLG / ICOSL 

    Transcripts
    for ICOSLG gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ICOSLG gene: 
    NM_015259.4  

    Unigene Cluster for ICOSLG:

    Inducible T-cell co-stimulator ligand
    Hs.14155  [show with all ESTs]
    Unigene Representative Sequence: NM_015259
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344330 ENST00000407780 ENST00000400379(uc002zee.3 uc011afc.2 uc010gpp.1)
    ENST00000400377(uc002zef.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ICOSLG
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ICOSLG
    1 QIAGEN miScript miRNA Assays for microRNA that regulate ICOSLG:
    hsa-miR-339-5p
    SwitchGear 3'UTR luciferase reporter plasmid: ICOSLG 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ICOSLG (see all 4)
    OriGene shRNA RFP: ICOSLG
    OriGene siRNA: ICOSLG
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ICOSLG
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ICOSLG (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ICOSLG
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ICOSLG (NM_015259)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ICOSLG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICOSLG 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ICOSLG
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ICOSLG
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ICOSLG

    Additional cDNA sequence: 

    AF199028.1 AF216749.1 AF289028.1 AK090492.1 AK290192.1 AK294031.1 AK311496.1 AK314369.1 
    AK316143.1 AK316176.1 AL355690.1 BC064637.1 

    6 DOTS entries:

    DT.121141597  DT.307580  DT.100750231  DT.311987  DT.100019380  DT.92420158 

    24/99 AceView cDNA sequences (see all 99):

    AI421115 BX281778 CK299365 AA812918 CR595366 BI488470 BM923293 BF221467 
    AF199028 AA781960 AA482045 AA778249 NM_015259 AI144115 AA476212 D45643 
    AF216749 AA733043 BM543561 AW150924 CB055212 BQ189193 AX746477 AK090492 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ICOSLG    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
    SP1:                                                  -               
    SP2:                          -                       -               
    SP3:                                                                  


    ECgene alternative splicing isoforms for ICOSLG

    Expression
    for ICOSLG gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ICOSLG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAAGCATTAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ICOSLG expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ICOSLG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ICOSLG

    SOURCE GeneReport for Unigene cluster: Hs.14155

    UniProtKB/Swiss-Prot: ICOSL_HUMAN, O75144
    Tissue specificity: Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal
    muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while
    isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells

        SABiosciences Expression via Pathway-Focused PCR Array including ICOSLG: 
              T-cell & B-cell Activation in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ICOSLG
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICOSLG

    Orthologs
    for ICOSLG gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ICOSLG gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ICOSLG1 inducible T-cell co-stimulator ligand 46.81(n)
    35.74(a)    		   395968  NM_205084.1  NP_990415.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ICOSLG6
    		 --
    		 32(a)
    		 1 ↔ 1
    		 3(136306624-136309882)


    ENSEMBL Gene Tree for ICOSLG (if available)
    TreeFam Gene Tree for ICOSLG (if available) 

    Paralogs
    for ICOSLG gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for ICOSLG gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/347 NCBI SNPs in ICOSLG are shown (see all 347)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 21 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs48188901,2
    		C,F,A,H,--45646256(+) CTTGAC/ATGGAG 1 -- ds500121Minor allele frequency- A:0.23NS EA NA WA 2348
    rs1396363511,2
    		--45646317(+) CTGGCA/GAGAGT 1 -- ds50010--------
    rs1497616131,2
    		--45646345(+) AGACCC/GGCAAG 1 -- ds50010--------
    rs1457119001,2
    		--45646497(+) AACAGC/TATCTG 1 -- ds50010--------
    rs1891906731,2
    		--45646514(+) CCACCC/TGCTGA 1 -- ds50010--------
    rs754738221,2
    		F,--45646537(+) GCCCCC/AAGCTG 1 -- ds50011Minor allele frequency- A:0.19WA 118
    rs1922330261,2
    		--45646595(+) ACGGAA/TCAGCC 1 -- ds50010--------
    rs65183521,2
    		C,F,A,H,--45646698(+) CCACCG/AAAGCC 1 -- ds500124Minor allele frequency- A:0.26NS EA WA NA CSA 2351
    rs1846697361,2
    		--45646820(+) TGTTGG/TGCTGA 1 -- ut310--------
    rs1884965441,2
    		--45646862(+) AATGCC/TGACGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ICOSLG (45642874 - 45660849 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ICOSLG
         2 CNVs: 30146 7327

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ICOSLG
    DNA2.0 Custom Variant and Variant Library Synthesis for ICOSLG

    Disorders / Diseases
    for ICOSLG gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ICOSLG for disorders           About GeneDecksing

    OMIM gene information: 605717    OMIM disorders: --

    20/22 diseases for ICOSLG (see all 22):    About MalaCards
    inclusion body myositis    ankylosing spondylitis    systemic lupus erythematosus    lupus erythematosus
    lupus nephritis    acute myeloid leukemia    myositis    myeloid leukemia
    spondylitis    nephritis    celiac disease    rheumatoid arthritis
    crohn's disease    tonsillitis    cholera    arthritis
    neuropathy    leukemia    asthma    melanoma

    3 Novoseek disease relationships for ICOSLG gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 5.28 2 15047591 (2)
    necrosis 0 3 11007762 (1), 14603470 (1), 16221208 (1)
    tumors 0 3 11007762 (1), 14603470 (1), 16221208 (1)

    Human Genome Epidemiology (HuGE) Navigator: ICOSLG (14 documents)

    Export disorders for ICOSLG gene to outside databases

    Publications
    for ICOSLG gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ICOSLG gene, integrated from 9 sources (see all 66):
    (articles sorted by number of sources associating them with ICOSLG)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS. (PubMed id 11007762)1, 2, 3, 9 Yoshinaga S.K.... Coccia M.A. (2000)
    2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (1998)
    3. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor. (PubMed id 10657606)1, 2 Ling V.... Collins M. (2000)
    6. Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS. (PubMed id 11023515)1, 2 Wang S.... Chen L. (2000)
    7. Characterization of human inducible costimulator ligand expression and function. (PubMed id 10779774)1, 2 Aicher A.... Clark E.A. (2000)
    8. [Expression of B7-related protein-1 on human coronary artery endothelial cells and its clinical significance] (PubMed id 19726311)1, 9 Xu L....Qiu J. (2009)
    9. Expression of the B7-related molecule ICOSL by human glioma cells in vitro and in vivo. (PubMed id 14603470)1, 9 Schreiner B....Wiendl H. (2003)
    10. Renal tubular epithelial cells modulate T-cell responses via ICOS-L and B7-H1. (PubMed id 16221208)1, 9 de Haij S....van Kooten C. (2005)

    External Searches for ICOSLG gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing ICOSLG gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23308 HGNC: 17087 AceView: ICOSL Ensembl:ENSG00000160223 euGenes: HUgn23308
    ECgene: ICOSLG Kegg: 23308 H-InvDB: ICOSLG

    Other Databases showing ICOSLG gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0653

    Specialized Databases showing ICOSLG gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ICOSLG Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ICOSLG gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ICOSLG gene:
    Search GeneIP for patents involving ICOSLG

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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