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ICOS Gene

protein-coding   GIFtS: 60
GCID: GC02P204765

Inducible T-Cell Co-Stimulator

  See ICOS-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Inducible T-Cell Co-Stimulator1 2     CD2782
Activation-Inducible Lymphocyte Immunomediatory Molecule1 2 3     Inducible Costimulator2
AILIM2 3 5     Inducible T-Cell Costimulator2
CVID12 5     CD278 Antigen3

External Ids:    HGNC: 53511   Entrez Gene: 298512   Ensembl: ENSG000001636007   OMIM: 6045585   UniProtKB: Q9Y6W83   

Export aliases for ICOS gene to outside databases

Previous GC identifers: GC02P203018 GC02P203526 GC02P205004 GC02P204626 GC02P204509 GC02P196648


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ICOS Gene:
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers
and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.
(provided by RefSeq, Jul 2008)

GeneCards Summary for ICOS Gene:
ICOS (inducible T-cell co-stimulator) is a protein-coding gene. Diseases associated with ICOS include autoimmune myocarditis, and icos-related common variable immune deficiency.

UniProtKB/Swiss-Prot: ICOS_HUMAN, Q9Y6W8
Function: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of
lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody
secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody
responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces
the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in
CD40-mediated class switching of immunoglobin isotypes (By similarity)

Gene Wiki entry for ICOS (CD278) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ICOS gene promoter:
         HOXA3   AML1a   Sp1   AP-1   ATF-2   LCR-F1   IRF-7A   Chx10   c-Jun   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidICOS promoter sequence
   Search Chromatin IP Primers for ICOS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ICOS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33   Ensembl cytogenetic band:  2q33.2   HGNC cytogenetic band: 2q33

ICOS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ICOS gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P204765:  view genomic region     (about GC identifiers)

Start:
204,801,471 bp from pter      End:
204,826,300 bp from pter
Size:
24,830 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ICOS_HUMAN, Q9Y6W8 (See protein sequence)
Recommended Name: Inducible T-cell costimulator precursor  
Size: 199 amino acids; 22625 Da
Subunit: Homodimer; disulfide-linked
Secondary accessions: Q8N6W8
Alternative splicing: 2 isoforms:  Q9Y6W8-1   Q9Y6W8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ICOS: NX_Q9Y6W8

Explore proteomics data for ICOS at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn23, Asn89, Asn110
  • Modification sites at PhosphoSitePlus

  • See ICOS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036224.1  
    ENSEMBL proteins: 
     ENSP00000319476   ENSP00000415951  

    ICOS Human Recombinant Protein Products:

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    Novus Biologicals ICOS Proteins
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    Sino Biological Recombinant Protein for ICOS
    Sino Biological Cell Lysate for ICOS
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    Cloud-Clone Corp. Proteins for ICOS

     
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    ICOS Antibody Products:

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    Cloud-Clone Corp. ELISAs for ICOS
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    Search eBioscience for ELISAs for ICOS 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules

    ProtoNet protein and cluster: Q9Y6W8

    UniProtKB/Swiss-Prot: ICOS_HUMAN, Q9Y6W8
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ICOS_HUMAN, Q9Y6W8
    Function: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of
    lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody
    secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody
    responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces
    the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in
    CD40-mediated class switching of immunoglobin isotypes (By similarity)
    Induction: By phorbol myristate acetate (PMA) and ionomycin. Up-regulated early on T-cells and continues to be
    expressed into the later phases of T-cell activation

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ICOS           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ICOS:
     Synthetic lethal with Ras 

         7 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Icos):
     digestive/alimentary  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system 
     no phenotypic analysis  tumorigenesis 

    Find genes that share phenotypes with ICOS           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ICOS: Icostm1Mak Icostm1Flv Icostm1Tkan Icostm1Dgry Icostm1Shr

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ICOS
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ICOS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ICOS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ICOS

    miRNA
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    Block miRNA regulation of human, mouse, rat ICOS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ICOS (see all 32):
    hsa-miR-3678-3p hsa-miR-607 hsa-let-7d hsa-miR-513a-5p hsa-miR-29a hsa-miR-10b* hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidICOS 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ICOS
    Predesigned siRNA for gene silencing in human, mouse, rat ICOS

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ICOS

    Clone
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    OriGene clones in human, mouse for ICOS (see all 5)
    OriGene ORF clones in mouse, rat for ICOS
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    GenScript: all cDNA clones in your preferred vector: ICOS (NM_015259)
    Sino Biological Human cDNA Clone for ICOS
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ICOS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICOS

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    Browse ESI BIO Cell Lines and PureStem Progenitors for ICOS 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICOS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ICOS_HUMAN, Q9Y6W8: Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential)
    ICOS_HUMAN, Q9Y6W8: Isoform 2: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    cytosol1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0009897external side of plasma membrane IEA--
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with ICOS           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ICOS About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1B cell receptor signaling pathway (KEGG)
    T cell receptor signaling pathway0.38
    TCR Signaling Pathway0.36
    2ICos-ICosL Pathway in T-Helper Cell
    ICos-ICosL Pathway in T-Helper Cell0.66
    3Immune response NFAT in immune response
    Immune response ICOS pathway in T helper cell0.55
    4CD28 co-stimulation
    Costimulation by the CD28 family0.44
    5Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41


    Find genes that share SuperPaths with ICOS           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ICOS
        ICos-ICosL Pathway in T-Helper Cell

    1 GeneGo (Thomson Reuters) Pathway for ICOS
        Immune response ICOS pathway in T-helper cell

    1 BioSystems Pathway for ICOS
        TCR Signaling Pathway



    4 Kegg Pathways  (Kegg details for ICOS):
        Cell adhesion molecules (CAMs)
    T cell receptor signaling pathway
    Intestinal immune network for IgA production
    Primary immunodeficiency

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ICOS: 
              Th17 Response in human mouse rat
              Th1/Th2 Response in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Allergy & Asthma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ICOS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for ICOS (Q9Y6W83 ENSP000003194764) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICOSLGO751443, ENSP000003844324I2D: score=4 STRING: ENSP00000384432
    CD40LGENSP000003596634STRING: ENSP00000359663
    PIK3CAENSP000002639674STRING: ENSP00000263967
    PIK3CBENSP000002891534STRING: ENSP00000289153
    PIK3CDENSP000003665634STRING: ENSP00000366563
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002517T cell tolerance induction IEA--
    GO:0006955immune response NAS9930702
    GO:0016337cell-cell adhesion IEA--
    GO:0031295T cell costimulation TAS--

    Find genes that share ontologies with ICOS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ICOS

    1 Novoseek inferred chemical compound relationship for ICOS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytidine 46.1 2 18025189 (1), 15963052 (1)



    Find genes that share compounds with ICOS           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ICOS gene: 
    NM_012092.3  

    Unigene Cluster for ICOS:

    Inducible T-cell co-stimulator
    Hs.56247  [show with all ESTs]
    Unigene Representative Sequence: NM_012092
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316386(uc010zip.1 uc002vam.3 uc010fua.3) ENST00000435193

    miRNA
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    Block miRNA regulation of human, mouse, rat ICOS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ICOS (see all 32):
    hsa-miR-3678-3p hsa-miR-607 hsa-let-7d hsa-miR-513a-5p hsa-miR-29a hsa-miR-10b* hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidICOS 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ICOS
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    OriGene ORF clones in mouse, rat for ICOS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ICOS (NM_015259)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ICOS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICOS
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ICOS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ICOS
      QuantiTect SYBR Green Assays in human, mouse, rat ICOS
      QuantiFast Probe-based Assays in human, mouse, rat ICOS

    Additional mRNA sequence: 

    AB023135.1 AJ277832.1 AK314985.1 BC028006.1 BC028210.1 

    2 DOTS entries:

    DT.40113835  DT.95364711 

    16 AceView cDNA sequences:

    BF061888 AB023135 AJ277832 BC028006 BI907838 NM_012092 BC028210 W57945 
    BX116591 CB528580 BI907242 BI818907 AW451448 W58028 CD709661 AW188759 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ICOS    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4
    SP1:                        
    SP2:              -         


    ECgene alternative splicing isoforms for ICOS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ICOS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ICOS Expression
    About this image


    ICOS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Blood (Hematopoietic System)
             T Helper Cells Peripheral Blood
    ICOS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ICOS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.56247

    UniProtKB/Swiss-Prot: ICOS_HUMAN, Q9Y6W8
    Tissue specificity: Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with
    B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower
    levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn
    thymus

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ICOS: 
              Th17 Response in human mouse rat
              Th1/Th2 Response in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              T-Cell Anergy & Immune Tolerance in human mouse rat
              Allergy & Asthma in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat ICOS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICOS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ICOS gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Icos1 , 5 inducible T cell co-stimulator1, 5 77.44(n)1
    69.7(a)1
      1 (30.60 cM)5
    541671  NM_017480.21  NP_059508.21 
     609779275 
    chicken
    (Gallus gallus)
    Aves ICOS6
    Gallus gallus inducible T-cell co-stimulator (ICOS...
    29(a)
    1 ↔ 1
    7(12876549-12889458)
    lizard
    (Anolis carolinensis)
    Reptilia ICOS6
    inducible T-cell co-stimulator
    22(a)
    1 ↔ 1
    GL344879.1(2973-13642)


    ENSEMBL Gene Tree for ICOS (if available)
    TreeFam Gene Tree for ICOS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ICOS (see all 493)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1473892821,2
    --204189600(+) TGCACA/GTGGAG 1 -- us2k10--------
    rs44521241,2
    C,F,A,H--204189609(+) AGCCCT/CGTGTC 1 -- us2k1 tfbs314Minor allele frequency- C:0.34NS EA NA CSA WA 791
    rs1396491071,2
    --204189662(+) CTGCTG/TTGTAT 1 -- us2k10--------
    rs1140498121,2
    C,F--204189767(+) CACCTA/GGGTTG 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1808453271,2
    --204189769(+) CCTAGA/GTTGGA 1 -- us2k10--------
    rs798977661,2
    C,F--204189863(+) ATGATG/ACTACG 1 -- us2k11Minor allele frequency- A:0.06WA 118
    rs1171108721,2
    F--204189894(+) GGAGAT/CTGGGG 1 -- us2k11Minor allele frequency- C:0.03EA 120
    rs1854842771,2
    C--204189921(+) GTCCTA/GGCAGC 1 -- us2k10--------
    rs115713051,2
    C,F--204190038(-) GATCCC/TCCTAG 1 -- us2k19Minor allele frequency- T:0.34WA NA CSA EA 370
    rs1166506561,2
    C,F--204190060(+) AGCCTC/TCTCCT 1 -- us2k11Minor allele frequency- T:0.05WA 118

    HapMap Linkage Disequilibrium report for ICOS (204801471 - 204826300 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ICOS:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv875720CNV Gain21882294

    Human Gene Mutation Database (HGMD): ICOS
    Locus Specific Mutation Databases (LSDB): ICOS

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ICOS
    DNA2.0 Custom Variant and Variant Library Synthesis for ICOS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604558   
    OMIM disorders: 607594  
    UniProtKB/Swiss-Prot: ICOS_HUMAN, Q9Y6W8
  • Immunodeficiency, common variable, 1 (CVID1) [MIM:607594]: A primary immunodeficiency characterized by
    antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody
    response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of
    immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 12 diseases for ICOS:    
    About MalaCards
    autoimmune myocarditis    icos-related common variable immune deficiency    immunodeficiency, common variable, 1    angioimmunoblastic t-cell lymphoma
    common variable immune deficiency    common variable immunodeficiency    autoimmune pancreatitis    immunodeficiency, common variable, 9
    paracoccidioidomycosis    myocarditis    primary sclerosing cholangitis    b-cell chronic lymphocytic leukemia


    Find genes that share disorders with ICOS           About GenesLikeMe

    8 Novoseek inferred disease relationships for ICOS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    icos deficiency 92.3 7 16757923 (4), 16630927 (1), 12577056 (1)
    common variable immunodeficiency 75.8 3 16757923 (1), 12577056 (1), 15963052 (1)
    autoimmune diseases 29.8 4 12753665 (1), 11904679 (1), 16187941 (1)
    lupus erythematosus systemic 22.4 1 17000707 (1)
    autoimmunity 6.47 1 16026134 (1)
    necrosis 0 1 19786798 (1)
    inflammation 0 2 14731127 (2)
    tumors 0 1 19786798 (1)

    GeneTests: ICOS
    GeneReviews: ICOS
    Genetic Association Database (GAD): ICOS
    Human Genome Epidemiology (HuGE) Navigator: ICOS (42 documents)

    Export disorders for ICOS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ICOS gene, integrated from 10 sources (see all 164):
    (articles sorted by number of sources associating them with ICOS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. (PubMed id 9930702)1, 2, 3 Hutloff A.... Kroczek R.A. (Nature 1999)
    2. Inducible CO-stimulator molecule, a candidate gene for defective isotype switching, is normal in patients with hyper-IgM syndrome of unknown molecular diagnosis. (PubMed id 14610488)1, 4, 9 Lee W.I....Ochs H.D. (J. Allergy Clin. Immunol. 2003)
    3. Association of genetic variation in inducible costimulator gene with outcome of kidney transplantation. (PubMed id 19202444)1, 4, 9 Haimila K....Partanen J. (Transplantation 2009)
    4. Functional polymorphism of CTLA-4 and ICOS genes in allogeneic hematopoietic stem cell transplantation. (PubMed id 19332044)1, 4, 9 Wu J....Yang Y.C. ( international journal of clinical chemistry 2009)
    5. Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. (PubMed id 12577056)1, 2, 9 Grimbacher B.... Peter H.H. (Nat. Immunol. 2003)
    6. Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with B-cell chronic lymphocytic leukemia in the Polish population. (PubMed id 18396212)1, 4, 9 Suwalska K....Frydecka I. (Hum. Immunol. 2008)
    7. Characterization of CD28, CTLA4, and ICOS polymorphisms in three Brazilian ethnic groups. (PubMed id 16112024)1, 4, 9 Guzman V.B....Gerbase-Delima M. (Hum. Immunol. 2005)
    8. Allelic variation of the inducible costimulator (ICOS) gene: detection of polymorphisms, analysis of the promoter region, and extended haplotype estimation. (PubMed id 12753665)1, 2, 9 Haaning Andersen A.D.... Lillevang S.T. (Tissue Antigens 2003)
    9. Association of the CD28/CTLA4/ICOS polymorphisms with susceptibility to rheumatoid arthritis. (PubMed id 20113255)1, 4, 9 Kim Y.O....Hong S.J. (Clin. Chem. Lab. Med. 2010)
    10. T-cell co-stimulation through B7RP-1 and ICOS. (PubMed id 10617205)1, 3, 9 Yoshinaga S.K....Senaldi G. (Nature 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29851 HGNC: 5351 AceView: ICOS Ensembl:ENSG00000163600 euGenes: HUgn29851
    ECgene: ICOS Kegg: 29851 H-InvDB: ICOS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ICOS Pharmacogenomics, SNPs, Pathways
    ICOSbasehttp://bioinf.uta.fi/ICOSbase/
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=ICOS[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ICOS gene:
    Search GeneIP for patents involving ICOS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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