ICOS Gene
protein-coding GIFtS: 61
GCID: GC02P204765
|
|
inducible T-cell co-stimulator
| |
Aliases
for ICOS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Inducible T-Cell Co-Stimulator1 2 | | CVID12 5 | | AILIM1 2 3 5 | | Inducible Costimulator2 | | CD2781 2 | | Inducible T-Cell Costimulator2 | | Activation-Inducible Lymphocyte Immunomediatory Molecule2 3 | | CD278 Antigen3 |
Export aliases for ICOS gene to outside databasesPrevious GC identifers: GC02P203018 GC02P203526 GC02P205004 GC02P204626 GC02P204509 GC02P196648 |
Summaries
for ICOS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ICOS:
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers andplays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ICOS_HUMAN, Q9Y6W8Function: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines,up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells.Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependentantigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10.Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching ofimmunoglobin isotypes (By similarity)
Gene Wiki entry for ICOS (CD278)
|
Genomic Views
for ICOS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ICOS gene promoter:
HOXA3 AML1a Sp1 AP-1 ATF-2 LCR-F1 IRF-7A Chx10 c-Jun Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for ICOS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ICOS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q33 Ensembl cytogenetic band: 2q33.2 HGNC cytogenetic band: 2q33ICOS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P204765: view genomic region
(about GC identifiers)
Start:
|
204,801,471 bp from pter |
End:
|
204,826,300 bp from pter |
Size:
|
24,830 bases |
Orientation:
|
plus strand |
|
Proteins
for ICOS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ICOS_HUMAN, Q9Y6W8 (See
protein sequence)Recommended Name: Inducible T-cell costimulator precursor Size: 199 amino acids; 22625 Da
Subunit: Homodimer; disulfide-linked
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential)
Subcellular location: Isoform 2: Secreted (Potential)
Secondary accessions: Q8N6W8Alternative splicing: 2 isoforms: Q9Y6W8-1 Q9Y6W8-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ICOS: NX_Q9Y6W8
Post-translational modifications:
N-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y6W8
ICOS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_036224.1
ENSEMBL proteins: ENSP00000319476 ENSP00000415951 Reactome Protein details: Q9Y6W8
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
ICOS for ontologies About GeneDecksing
ICOS Antibody Products:
Assay Products for ICOS: |
Protein
Domains /
Families
for ICOS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9Y6W8 UniProtKB/Swiss-Prot: ICOS_HUMAN, Q9Y6W8Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain |
Function
for ICOS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ICOS_HUMAN, Q9Y6W8Function: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines,up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells.Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependentantigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10.Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching ofimmunoglobin isotypes (By similarity)Induction: By phorbol myristate acetate (PMA) and ionomycin. Up-regulated early on T-cells and continues to beexpressed into the later phases of T-cell activation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ICOS (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ICOS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ICOS (NM_015259) | |  | Sino Biological Human cDNA Clone for ICOS | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ICOS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICOS |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICOS |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- |
ICOS for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ICOS:
Animal Models:
Mouse knock-outs for ICOS: Icostm1Mak Icostm1Flv Icostm1Shr Icostm1Tkan Icostm1Dgry
8 MGI mutant phenotypes (inferred from 7 alleles ) (MGI details for Icos):
ICOS for phenotypes About GeneDecksing
|
Pathways & Interactions
for ICOS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune System | | | 2 | Immune response_ICOS pathway in T-helper cell | | | 3 | B cell receptor signaling pathway | | | 4 | ICos-ICosL Pathway in T-Helper Cell | | | 5 | Primary immunodeficiency | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for ICOS
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ICOS
1  GeneGo (Thomson Reuters) Pathway for ICOS
1  BioSystems Pathway for ICOS
3 
Reactome Pathways for ICOS
4 
Kegg Pathways (Kegg details for ICOS):
ICOS for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ICOS
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/14 Interacting proteins for ICOS (Q9Y6W83 ENSP000003194764) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
ICOS for ontologies About GeneDecksing
|
Drugs & Compounds
for ICOS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ICOS for compounds About GeneDecksing
 Browse Tocris compounds for ICOS
1 Novoseek chemical compound relationship for ICOS gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cytidine |
46.1 |
2 |
18025189 (1), 15963052 (1) |
Search CenterWatch for drugs/clinical trials and news about ICOS
|
Transcripts
for ICOS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ICOS gene: NM_012092.3 Unigene Cluster for ICOS: Inducible T-cell co-stimulator Hs.56247 [show with all ESTs]Unigene Representative Sequence: NM_0120922 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000316386(uc010zip.1 uc002vam.3 uc010fua.3) ENST00000435193
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ICOS (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ICOS
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ICOS (NM_015259) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ICOS | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICOS |
Additional cDNA sequence: AB023135.1 AJ277832.1 AK314985.1 BC028006.1 BC028210.1 2 DOTS entries: DT.40113835 DT.95364711 16 AceView cDNA sequences: BI907838 BF061888 BC028006 NM_012092 AJ277832 AB023135 BC028210 BI907242 CB528580 W57945 BX116591 BI818907 W58028 AW451448 CD709661 AW188759
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for ICOS About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | - | | | |
ECgene alternative splicing isoforms for ICOS
|
Expression
for ICOS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ICOS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ICOS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ICOS
SOURCE GeneReport for Unigene cluster: Hs.56247
UniProtKB/Swiss-Prot: ICOS_HUMAN, Q9Y6W8Tissue specificity: Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cellsin the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels inthymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus
SABiosciences Expression via Pathway-Focused PCR Arrays including ICOS:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ICOS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ICOS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ICOS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ICOS | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICOS |
Orthologs
for ICOS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ICOS gene from 2/7 species (see all 7) About this table
ENSEMBL Gene Tree for ICOS (if available)
TreeFam Gene Tree for ICOS (if available) |
Paralogs
for ICOS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ICOS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ICOS (204801471 - 204826300 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ICOS: --
Human Gene Mutation Database (HGMD): ICOS
Locus Specific Mutation Databases (LSDB): ICOS
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ICOS |
|
Disorders
/ Diseases
for ICOS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ICOS for disorders About GeneDecksing
OMIM gene information: 604558
OMIM disorders: 607594
UniProtKB/Swiss-Prot: ICOS_HUMAN, Q9Y6W8
Defects in ICOS are the cause of immunodeficiency common variable type 1 (CVID1) [MIM:607594]. CVID1 is aprimary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infectionsand an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiationand impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but canbe lo
20/67  diseases for ICOS (see all 67): About MalaCardscommon variable immunodeficiency icos deficiency hypersensitivity reaction type ii disease graft versus host disease
sclerosing cholangitis primary sclerosing cholangitis pre-eclampsia non-hodgkin lymphoma
alopecia areata primary biliary cirrhosis squamous cell carcinoma lupus erythematosus
cholangitis oral squamous cell carcinoma cervical squamous cell carcinoma primary pulmonary hypertension
systemic lupus erythematosus allergic rhinitis hodgkin's lymphoma autoimmune myocarditis
8 Novoseek disease relationships for ICOS gene About this table
GeneTests: ICOS
Common Variable Immune Deficiency
Genetic Association Database (GAD): ICOS
Human Genome Epidemiology (HuGE) Navigator: ICOS (42 documents)
Export disorders for ICOS gene to outside databases
|
Publications
for ICOS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ICOS gene, integrated from 9 sources (see all 155):
(articles sorted by number of sources associating them with ICOS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. (PubMed id 9930702)1, 2, 3 Hutloff A.... Kroczek R.A. (1999)
- Inducible CO-stimulator molecule, a candidate gene for defective isotype switching, is normal in patients with hyper-IgM syndrome of unknown molecular diagnosis. (PubMed id 14610488)1, 4, 9 Lee W.I....Ochs H.D. (2003)
- Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. (PubMed id 12577056)1, 2, 9 Grimbacher B.... Peter H.H. (2003)
- Characterization of CD28, CTLA4, and ICOS polymorphisms in three Brazilian ethnic groups. (PubMed id 16112024)1, 4, 9 Guzman V.B....Gerbase-Delima M. (2005)
- Allelic variation of the inducible costimulator (ICOS) gene: detection of polymorphisms, analysis of the promoter region, and extended haplotype estimation. (PubMed id 12753665)1, 2, 9 Haaning Andersen A.D.... Lillevang S.T. (2003)
- T-cell co-stimulation through B7RP-1 and ICOS. (PubMed id 10617205)1, 3, 9 Yoshinaga S.K....Senaldi G. (1999)
- Haplotypes in the CTLA4 region are associated with coeliac disease in the Irish population. (PubMed id 16237465)1, 4 Brophy K....McManus R. (2006)
- Genetic analysis of the 2q33 region containing CD28-CTLA4-ICOS genes: association with non-Hodgkin's lymphoma. (PubMed id 15953005)1, 4 Piras G....Gabbas A. (2005)
- A common CTLA4 haplotype associated with coeliac disease. (PubMed id 15657618)1, 4 Hunt K.A.... van Heel D.A. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
|
External Searches for ICOS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ICOS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ICOS gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ICOS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ICOS | Pharmacogenomics, SNPs, Pathways | | ICOSbase | http://bioinf.uta.fi/ICOSbase/ | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ICOS |
|
| | |
About This Section
| Patent Information for ICOS gene:
Search GeneIP for patents involving ICOS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ICOS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for ICOS | | OriGene shRNA RFP for ICOS | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ICOS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ICOS | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ICOS | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ICOS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ICOS | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ICOS | | OriGene Custom Protein Services for ICOS | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ICOS | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ICOS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ICOS | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ICOS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ICOS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ICOS |
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 |  |  |  | |
| | | | Search Tocris compounds for ICOS |
| |  |  |  |  | | | | |
 |
 |
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 | | | ICOS Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICOS |
|  |  |  | | | | ThermoFisher Antibodies for ICOS |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICOS |
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