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Aliases for ICOS Gene

Aliases for ICOS Gene

  • Inducible T-Cell Co-Stimulator 2 3 5
  • Activation-Inducible Lymphocyte Immunomediatory Molecule 2 3 4
  • AILIM 3 4
  • Inducible Costimulator 3
  • CD278 Antigen 4
  • CD278 3
  • CVID1 3

External Ids for ICOS Gene

Previous GeneCards Identifiers for ICOS Gene

  • GC02P203018
  • GC02P203526
  • GC02P204765
  • GC02P205004
  • GC02P204626
  • GC02P204509
  • GC02P196648

Summaries for ICOS Gene

Entrez Gene Summary for ICOS Gene

  • The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ICOS Gene

ICOS (Inducible T-Cell Co-Stimulator) is a Protein Coding gene. Diseases associated with ICOS include immunodeficiency, common variable, 1 and common variable immunodeficiency. Among its related pathways are Immune System and Innate Lymphoid Cell Differentiation Pathways.

UniProtKB/Swiss-Prot for ICOS Gene

  • Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).

Gene Wiki entry for ICOS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICOS Gene

Genomics for ICOS Gene

Regulatory Elements for ICOS Gene

Promoters for ICOS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ICOS on UCSC Golden Path with GeneCards custom track

Genomic Location for ICOS Gene

Chromosome:
2
Start:
203,936,731 bp from pter
End:
203,961,579 bp from pter
Size:
24,849 bases
Orientation:
Plus strand

Genomic View for ICOS Gene

Genes around ICOS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICOS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICOS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICOS Gene

Proteins for ICOS Gene

  • Protein details for ICOS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6W8-ICOS_HUMAN
    Recommended name:
    Inducible T-cell costimulator
    Protein Accession:
    Q9Y6W8
    Secondary Accessions:
    • Q8N6W8

    Protein attributes for ICOS Gene

    Size:
    199 amino acids
    Molecular mass:
    22625 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Alternative splice isoforms for ICOS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ICOS Gene

Proteomics data for ICOS Gene at MOPED

Post-translational modifications for ICOS Gene

Other Protein References for ICOS Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ICOS (ICOS)

No data available for DME Specific Peptides for ICOS Gene

Domains & Families for ICOS Gene

Gene Families for ICOS Gene

Protein Domains for ICOS Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9Y6W8

UniProtKB/Swiss-Prot:

ICOS_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with ICOS: view

Function for ICOS Gene

Molecular function for ICOS Gene

UniProtKB/Swiss-Prot Function:
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
UniProtKB/Swiss-Prot Induction:
By phorbol myristate acetate (PMA) and ionomycin. Up-regulated early on T-cells and continues to be expressed into the later phases of T-cell activation.
genes like me logo Genes that share phenotypes with ICOS: view

Human Phenotype Ontology for ICOS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ICOS Gene

MGI Knock Outs for ICOS:

Animal Model Products

miRNA for ICOS Gene

miRTarBase miRNAs that target ICOS

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for ICOS Gene

Localization for ICOS Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICOS Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ICOS Gene COMPARTMENTS Subcellular localization image for ICOS gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ICOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with ICOS: view

Pathways & Interactions for ICOS Gene

genes like me logo Genes that share pathways with ICOS: view

Gene Ontology (GO) - Biological Process for ICOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002517 T cell tolerance induction IEA --
genes like me logo Genes that share ontologies with ICOS: view

No data available for SIGNOR curated interactions for ICOS Gene

Drugs & Compounds for ICOS Gene

(1) Drugs for ICOS Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ICOS: view

Transcripts for ICOS Gene

mRNA/cDNA for ICOS Gene

Unigene Clusters for ICOS Gene

Inducible T-cell co-stimulator:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ICOS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4
SP1:
SP2: -

Relevant External Links for ICOS Gene

GeneLoc Exon Structure for
ICOS
ECgene alternative splicing isoforms for
ICOS

Expression for ICOS Gene

mRNA expression in normal human tissues for ICOS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ICOS Gene

This gene is overexpressed in Whole Blood (x15.2), Small Intestine - Terminal Ileum (x7.1), Spleen (x6.0), and Lung (x4.2).

SOURCE GeneReport for Unigene cluster for ICOS Gene Hs.56247

mRNA Expression by UniProt/SwissProt for ICOS Gene

Q9Y6W8-ICOS_HUMAN
Tissue specificity: Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.
genes like me logo Genes that share expression patterns with ICOS: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ICOS Gene

Orthologs for ICOS Gene

This gene was present in the common ancestor of chordates.

Orthologs for ICOS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ICOS 35
  • 83.67 (n)
  • 73.74 (a)
ICOS 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ICOS 35
  • 84.26 (n)
  • 71.57 (a)
ICOS 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Icos 35
  • 77.44 (n)
  • 69.7 (a)
Icos 16
Icos 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ICOS 35
  • 99.16 (n)
  • 99.5 (a)
ICOS 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Icos 35
  • 77.54 (n)
  • 68.95 (a)
oppossum
(Monodelphis domestica)
Mammalia ICOS 36
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ICOS 36
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves ICOS 36
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ICOS 36
  • 22 (a)
OneToOne
Species with no ortholog for ICOS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ICOS Gene

ENSEMBL:
Gene Tree for ICOS (if available)
TreeFam:
Gene Tree for ICOS (if available)

Paralogs for ICOS Gene

No data available for Paralogs for ICOS Gene

Variants for ICOS Gene

Sequence variations from dbSNP and Humsavar for ICOS Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1559931 -- 203,961,006(+) AATAT(A/G)TGGAA utr-variant-3-prime
rs4404254 -- 203,960,563(+) TTTAG(C/T)TCTTT utr-variant-3-prime
rs4264550 -- 203,956,771(+) GTAAG(C/G/T)GATTT intron-variant
rs4270326 -- 203,956,891(+) CCCCC(C/G)AAGAC intron-variant
rs4521021 -- 203,951,852(+) TATTT(C/T)ACTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ICOS Gene

Variant ID Type Subtype PubMed ID
nsv875720 CNV Gain 21882294

Variation tolerance for ICOS Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ICOS Gene

HapMap Linkage Disequilibrium report
ICOS
Human Gene Mutation Database (HGMD)
ICOS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICOS Gene

Disorders for ICOS Gene

MalaCards: The human disease database

(5) MalaCards diseases for ICOS Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency, common variable, 1
  • cvid1
common variable immunodeficiency
  • acquired agammaglobulinemia
icos-related common variable immune deficiency
  • immunodeficiency, common variable, 1
good syndrome
  • thymoma with hypogammaglobulinemia
diffuse cutaneous systemic sclerosis
  • diffuse scleroderma
- elite association - COSMIC cancer census association via MalaCards
Search ICOS in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ICOS_HUMAN
  • Immunodeficiency, common variable, 1 (CVID1) [MIM:607594]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269 PubMed:12577056}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ICOS

Genetic Association Database (GAD)
ICOS
Human Genome Epidemiology (HuGE) Navigator
ICOS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ICOS
genes like me logo Genes that share disorders with ICOS: view

No data available for Genatlas for ICOS Gene

Publications for ICOS Gene

  1. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. (PMID: 9930702) Hutloff A. … Kroczek R.A. (Nature 1999) 2 3 4 67
  2. T-cell co-stimulation through B7RP-1 and ICOS. (PMID: 10617205) Yoshinaga S.K. … Senaldi G. (Nature 1999) 2 3 23
  3. The inducible T-cell co-stimulator molecule is expressed on subsets of T cells and is a new marker of lymphomas of T follicular helper cell-derivation. (PMID: 20207847) Marafioti T. … Gaulard P. (Haematologica 2010) 3 23
  4. Association of the CD28/CTLA4/ICOS polymorphisms with susceptibility to rheumatoid arthritis. (PMID: 20113255) Kim Y.O. … Hong S.J. (Clin. Chem. Lab. Med. 2010) 3 23
  5. Antigen-independent adhesion and cell spreading by inducible costimulator engagement inhibits T cell migration in a PI-3K-dependent manner. (PMID: 19095735) Franko J.L. … Levine A.D. (J. Leukoc. Biol. 2009) 3 23

Products for ICOS Gene

Sources for ICOS Gene

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