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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ICMT Gene

protein-coding   GIFtS: 61
GCID: GC01M006282

isoprenylcysteine carboxyl methyltransferase
 Explore 18 diseases affiliated with
ICMT via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ICMT    

Aliases
for ICMT gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Isoprenylcysteine Carboxyl Methyltransferase1 2     MST0982
PCCMT1 2 3     MSTP0982
PPMT1 2 3     PCMT2
HSTE141 2     Protein-S Isoprenylcysteine O-Methyltransferase2
Prenylated Protein Carboxyl Methyltransferase2 3     Protein-S-Isoprenylcysteine O-Methyltransferase2
Prenylcysteine Carboxyl Methyltransferase2 3     Isoprenylcysteine Carboxylmethyltransferase3
EC 2.1.1.1003 8     PcCMT1

External Ids:    HGNC: 53501   Entrez Gene: 234632   Ensembl: ENSG000001162377   OMIM: 6058515   UniProtKB: O607253   

Export aliases for ICMT gene to outside databases

Previous GC identifers: GC01M005857 GC01M006090 GC01M005990 GC01M006215 GC01M005429


Summaries
for ICMT gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ICMT:
This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues
in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic
reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those
transcripts has not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ICMT_HUMAN, O60725
Function: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues

Gene Wiki entry for ICMT


Genomic Views
for ICMT gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_021937.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ICMT gene promoter:
         Max1   Bach2   NRSF form 1   NRSF form 2   COMP1   STAT3   ARP-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ICMT promoter sequence
   Search SABiosciences Chromatin IP Primers for ICMT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ICMT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.21   Ensembl cytogenetic band:  1p36.31   HGNC cytogenetic band: 1p36

ICMT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ICMT gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M006282:  view genomic region     (about GC identifiers)

Start:
 6,281,252 bp from pter      End:
 6,296,044 bp from pter
Size:
 14,793 bases      Orientation:
 minus strand

Proteins
for ICMT gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ICMT_HUMAN, O60725 (See protein sequence)
Recommended Name: Protein-S-isoprenylcysteine O-methyltransferase  
Size: 284 amino acids; 31938 Da
Cofactor: Divalent cations. Probably zinc (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Secondary accessions: Q6FHT0

Explore the universe of human proteins at neXtProt for ICMT: NX_O60725

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60725

    • 4/6 DME Specific Peptides for ICMT (O60725) (see all 6)
     RHPSYVG  SFLLNHS  SLIHFFGE  GTQVMLCNP 

    ICMT Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_036537.1  
    ENSEMBL proteins: 
     ENSP00000343552   ENSP00000466222   ENSP00000467999   ENSP00000354894  

    Human Recombinant Protein Products: 
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    Novus Biologicals ICMT Proteins
    Novus Biologicals ICMT Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ICMT

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005783endoplasmic reticulum IDA9614111
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016020membrane TAS10441503
    GO:0016021integral to membrane IEA--


    ICMT for ontologies           About GeneDecksing



    ICMT Antibody Products: 
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    Search for Antibodies for ICMT at Abcam  
    Uscn Antibodies for ICMT
    ThermoFisher Antibodies for ICMT

    Assay Products for ICMT: 
    Browse Kits and Assays available from EMD Millipore
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    Uscn ELISAs and CLIAs for ICMT

    Protein Domains /
    Families
    for ICMT gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ICMT for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR007269 ICMT_MeTrfase
     IPR025770 PPMT_MeTrfase

    Graphical View of Domain Structure for InterPro Entry O60725

    ProtoNet protein and cluster: O60725

    2 Blocks protein families:
    IPB007269 Isoprenylcysteine carboxyl methyltransferase
    IPB011024 Gamma-crystallin related


    UniProtKB/Swiss-Prot: ICMT_HUMAN, O60725
    Similarity: Belongs to the isoprenylcysteine O-methyltransferase family


    Function
    for ICMT gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ICMT_HUMAN, O60725
    Function: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues
    Catalytic activity: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine +
    protein C-terminal S-farnesyl-L-cysteine methyl ester

    Enzyme Number (IUBMB): EC 2.1.1.1001 2

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ICMT
    8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate ICMT (see all 62):
    hsa-miR-4328 hsa-let-7d hsa-miR-106a hsa-miR-16-1* hsa-miR-3653 hsa-miR-519a hsa-let-7g hsa-miR-3142
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ICMT (see all 7)
    OriGene shRNA RFP: ICMT
    OriGene siRNA: ICMT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ICMT

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ICMT

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ICMT (see all 3)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICMT 

    Cell Line
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    Search LifeMap BioReagents cell lines for ICMT

    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003880protein C-terminal carboxyl O-methyltransferase activity TAS9614111
    GO:0004671protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity IEA--
    GO:0008140cAMP response element binding protein binding IEA--


    ICMT for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ICMT:
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-outs for ICMT: Icmttm1Hzo Icmttm1Sgy
         8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Icmt):
     cellular  embryogenesis  growth/size  hematopoietic system  liver/biliary system 
     mortality/aging  nervous system  normal 

    ICMT for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ICMT gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1G-protein signaling K-RAS regulation pathway
    		G-protein signaling K-RAS regulation pathway1.00
    		G-protein signaling H-RAS regulation pathway0.27
    		G-protein signaling_K-RAS regulation pathway0.96
    		G-protein signaling_H-RAS regulation pathway0.27
    2G-protein signaling N-RAS regulation pathway
    		G-protein signaling N-RAS regulation pathway1.00
    		G-protein signaling_N-RAS regulation pathway0.83

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for ICMT
        G-protein signaling K-RAS regulation pathway
    G-protein signaling N-RAS regulation pathway
    G-protein signaling H-RAS regulation pathway


    3 GeneGo (Thomson Reuters) Pathways for ICMT
        G-protein signaling H-RAS regulation pathway
    G-protein signaling K-RAS regulation pathway
    G-protein signaling N-RAS regulation pathway



    ICMT for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ICMT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/17 Interacting proteins for ICMT (O607253 ENSP000003435524) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAC2P151533, ENSP000002490714I2D: score=3 STRING: ENSP00000249071
    RHOAP615863, ENSP000004001754I2D: score=3 STRING: ENSP00000400175
    HRASP011123, ENSP000003098454I2D: score=2 STRING: ENSP00000309845
    ZMPSTE24O758443, ENSP000003618454I2D: score=1 STRING: ENSP00000361845
    RAC1P630003, ENSP000003484614I2D: score=2 STRING: ENSP00000348461
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001889liver development IEA--
    GO:0006464cellular protein modification process TAS9614111
    GO:0006479protein methylation ----
    GO:0006481C-terminal protein methylation TAS10441503


    ICMT for ontologies           About GeneDecksing



    Drugs & Compounds
    for ICMT gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ICMT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ICMT

    2 HMDB Compounds for ICMT    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--
    7 Novoseek chemical compound relationships for ICMT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysmethynil 98.4 13 17209565 (2), 15784746 (2), 16757321 (1), 19157999 (1) (see all 6)
    s-adenosylhomocysteine 81.8 5 17360897 (2), 12631708 (1), 12750467 (1)
    s-adenosylmethionine 69.5 4 12631708 (1), 17360897 (1), 15625008 (1)
    homocysteine 51.5 3 12750467 (1), 17360897 (1)
    cysteine 35.8 4 16757321 (1), 15625008 (1)
    indole 32.9 3 17209565 (3)
    aspartate 4.56 2 11985579 (1), 10880963 (1)

    Search CenterWatch for drugs/clinical trials and news about ICMT 

    Transcripts
    for ICMT gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ICMT gene (2 alternative transcripts): 
    NM_012405.3  NM_170705.1  

    Unigene Cluster for ICMT:

    Isoprenylcysteine carboxyl methyltransferase
    Hs.515688  [show with all ESTs]
    Unigene Representative Sequence: NM_012405
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483852 ENST00000343813(uc001amk.3 uc001aml.3) ENST00000495791
    ENST00000489498 ENST00000474756 ENST00000362035

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ICMT
    8/62 QIAGEN miScript miRNA Assays for microRNAs that regulate ICMT (see all 62):
    hsa-miR-4328 hsa-let-7d hsa-miR-106a hsa-miR-16-1* hsa-miR-3653 hsa-miR-519a hsa-let-7g hsa-miR-3142
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ICMT (see all 7)
    OriGene shRNA RFP: ICMT
    OriGene siRNA: ICMT
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ICMT
    Clone
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    Additional cDNA sequence: 

    AF173157.1 BC028168.1 CR541671.1 CR541711.1 

    16 DOTS entries:

    DT.100790533  DT.87017640  DT.100790540  DT.86855797  DT.95345873  DT.100790531  DT.95343582  DT.100790535 
    DT.121366499  DT.91771617  DT.40109201  DT.40109202  DT.86840009  DT.100029749  DT.91749368  DT.95283915 

    24/374 AceView cDNA sequences (see all 374):

    BM676563 BC017037 BU157494 AA934651 CR595162 AI085228 CA413730 AI383141 
    CN481591 CB162974 AL558860 AA903411 AW169682 BM995289 AA487020 BE501534 
    NM_170705 AI434366 BE740204 BU617580 AI636921 BU955941 AI214943 NM_012405 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ICMT    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:                                                                  
    SP2:                    -                                             
    SP3:                    -                                             
    SP4:                    -     -                                       


    ECgene alternative splicing isoforms for ICMT

    Expression
    for ICMT gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ICMT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGTTTGGAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ICMT expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver BudHepatoblastsLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ICMT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ICMT

    SOURCE GeneReport for Unigene cluster: Hs.515688

    UniProtKB/Swiss-Prot: ICMT_HUMAN, O60725
    Tissue specificity: Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other
    brain regions. Abundant expression seen in the Purkinje cells and pontine neurons

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    In Situ
    Assay Products:     
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    Orthologs
    for ICMT gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ICMT gene from 9/33 species (see all 33)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Icmt1 , 5 isoprenylcysteine carboxyl methyltransferase1, 5 89.08(n)1
    96.13(a)1    		   4 (83.02 cM)5
    572951  NM_133788.21  NP_598549.11 
     1522972275 
    chicken
    (Gallus gallus)    		 Aves ICMT1 isoprenylcysteine carboxyl methyltransferase 75.15(n)
    77.74(a)    		   419373  NM_001006298.1  NP_001006298.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3977172 farnesyl cysteine carboxyl methyltransferase 73.58(n)    D87750.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii icmt1 isoprenylcysteine carboxyl methyltransferase 63.71(n)
    65.31(a)    		   550281  NM_001017618.1  NP_001017618.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG112683
    ste141    		 protein-S-isoprenylcysteine
    O-methyltransferase3
    isoprenylcysteine carboxylmethyltransferase1    		 49(a)3
    54.74(n)1
    51.66(a)1    		   69F53
    394781  NM_140366.21  NP_648623.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea M01E11.11 , 3 Protein M01E11.11 43(a)
    (best of 2)3
    51.91(n)1
    46.27(a)1    		   I(5582106-5583267)3
    1873741  NM_059234.31  NP_491635.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes STE14(YDR410C)4
    STE141    		 Farnesyl cysteine-carboxyl methyltransferase, mediates more4
    Ste14p1    		 50.69(n)1
    42.4(a)1    		   4(1293091-1292372)4
    8520191, 4  NP_010698.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons STE14A1 protein-S-isoprenylcysteine O-methyltransferase A 51.13(n)
    45.55(a)    		   832396  NM_122238.1  NP_197723.1 
    rice
    (Oryza sativa)    		 Liliopsida Os04g06029001 hypothetical protein 52.89(n)
    47.33(a)    		   4336894  NM_001060312.1  NP_001053777.1 


    ENSEMBL Gene Tree for ICMT (if available)
    TreeFam Gene Tree for ICMT (if available) 

    Paralogs
    for ICMT gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for ICMT gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/304 NCBI SNPs in ICMT are shown (see all 304)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1125902431,2
    		C,--5445389(+) GTACCT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs22065401,2
    		C--5445984(-) GCTACC/TTGAGG 1 -- nc-transcript-variant1Minor allele frequency- T:0.00NA 2
    rs412789221,2
    		C,--6280872(+) GTGACG/CTAAAA 2 -- ut31 ds50015Minor allele frequency- C:0.17NA WA EA 362
    rs1132881721,2
    		--6280915(+) GATAGC/TCACAT 2 -- ut31 ds50011Minor allele frequency- T:0.50CSA 2
    rs1403605231,2
    		--6280998(+) ACACAC/TAACAC 2 -- ds5001 ut310--------
    rs66899401,2
    		C,F,A,H,--6281090(+) ATGTGG/ATGGCC 2 -- ut31 ds500113Minor allele frequency- A:0.10NS EA NA WA 1472
    rs1864157051,2
    		--6281121(+) CATTAA/CAACTG 2 -- ut31 ds50010--------
    rs1884762171,2
    		--6281250(+) CACTGC/TGGTTG 2 -- ut31 ds50010--------
    rs1808960391,2
    		--6281256(+) GGTTGA/GGTGAA 2 -- ut310--------
    rs10647211,2
    		C,F,A,H,--6281377(-) TGAACG/AGNNNN 2 -- int1 ut3119Minor allele frequency- A:0.11MN NA NS EA WA 2510

    HapMap Linkage Disequilibrium report for ICMT (6281252 - 6296044 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ICMT
         1 CNV: 4200

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ICMT
    DNA2.0 Custom Variant and Variant Library Synthesis for ICMT

    Disorders / Diseases
    for ICMT gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ICMT for disorders           About GeneDecksing

    OMIM gene information: 605851    OMIM disorders: --

    18 diseases for ICMT:    About MalaCards
    spina bifida    hereditary spherocytosis    legionnaires' disease    spinocerebellar ataxia
    hyperhomocysteinemia    spherocytosis    uremia    endometrial carcinoma
    liver disease    ataxia    homocysteine    alzheimer's disease
    neuroblastoma    melanoma    carcinoma    malaria
    neuronitis    alcoholism

    4 Novoseek disease relationships for ICMT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperhomocysteinemia 52.6 1 17360897 (1)
    necrosis 0 2 12631708 (1), 12006387 (1)
    tumors 0 2 12631708 (1), 12006387 (1)
    cancer 0 3 17964784 (1), 18466935 (1), 15784746 (1)

    Human Genome Epidemiology (HuGE) Navigator: ICMT (2 documents)

    Export disorders for ICMT gene to outside databases

    Publications
    for ICMT gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ICMT gene, integrated from 9 sources (see all 67):
    (articles sorted by number of sources associating them with ICMT)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. (PubMed id 9614111)1, 2, 3, 9 Dai Q.... Philips M.R. (1998)
    2. Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe. (PubMed id 19158273)1, 2, 9 Wright L.P....Philips M.R. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1. (PubMed id 10649571)1, 2 Lin X.... Zoghbi H.Y. (2000)
    5. The carboxyl methyltransferase modifying G proteins is a metalloenzyme. (PubMed id 10441503)1, 3 Desrosiers R.R....Beliveau R. (1999)
    6. Inhibition of ICMT induces endothelial cell apoptosis through GRP94. (PubMed id 17347446)1, 9 Lu Q....Rounds S. (2007)
    7. Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis. (PubMed id 12631708)1, 9 Kramer K....Rounds S. (2003)
    8. Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate. (PubMed id 12750467)1, 9 Winter-Vann A.M....Casey P.J. (2003)
    9. Role of isoprenylcysteine carboxylmethyltransferase-c atalyzed methylation in Rho function and migration. (PubMed id 19651782)1, 9 Cushman I. and Casey P.J. (2009)
    10. Role of isoprenylcysteine carboxyl methyltransferase in tumor necrosis factor-alpha stimulation of expression of vascular cell adhesion molecule-1 in endothelial cells. (PubMed id 12006387)1, 9 Ahmad M....Alexander R.W. (2002)

    External Searches for ICMT gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ICMT gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23463 HGNC: 5350 AceView: ICMT Ensembl:ENSG00000116237 euGenes: HUgn23463
    ECgene: ICMT H-InvDB: ICMT

    Other Databases showing ICMT gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ICMT gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ICMT Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ICMT gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ICMT gene:
    Search GeneIP for patents involving ICMT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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