Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ICMT Gene

Aliases for ICMT Gene

  • Isoprenylcysteine Carboxyl Methyltransferase 2 3
  • Protein-S-Isoprenylcysteine O-Methyltransferase 2 3
  • Prenylated Protein Carboxyl Methyltransferase 3 4
  • Prenylcysteine Carboxyl Methyltransferase 3 4
  • EC 2.1.1.100 4 63
  • PCCMT 3 4
  • PPMT 3 4
  • Protein-S Isoprenylcysteine O-Methyltransferase 3
  • Isoprenylcysteine Carboxylmethyltransferase 4
  • MSTP098 3
  • HSTE14 3
  • MST098 3
  • PCMT 3

External Ids for ICMT Gene

Summaries for ICMT Gene

Entrez Gene Summary for ICMT Gene

  • This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ICMT Gene

ICMT (Isoprenylcysteine Carboxyl Methyltransferase) is a Protein Coding gene. Among its related pathways are G-protein signaling_K-RAS regulation pathway and Immune response Antigen presentation by MHC class II. GO annotations related to this gene include cAMP response element binding protein binding and protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity.

UniProtKB/Swiss-Prot for ICMT Gene

  • Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues

Gene Wiki entry for ICMT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICMT Gene

Genomics for ICMT Gene

Genomic Location for ICMT Gene

Start:
6,221,193 bp from pter
End:
6,235,984 bp from pter
Size:
14,792 bases
Orientation:
Minus strand

Genomic View for ICMT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ICMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICMT Gene

Regulatory Elements for ICMT Gene

Proteins for ICMT Gene

  • Protein details for ICMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60725-ICMT_HUMAN
    Recommended name:
    Protein-S-isoprenylcysteine O-methyltransferase
    Protein Accession:
    O60725
    Secondary Accessions:
    • Q6FHT0

    Protein attributes for ICMT Gene

    Size:
    284 amino acids
    Molecular mass:
    31938 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Divalent metal cations. Probably Zn(2+).;
    Quaternary structure:
    No Data Available

neXtProt entry for ICMT Gene

Proteomics data for ICMT Gene at MOPED

Selected DME Specific Peptides for ICMT Gene

Post-translational modifications for ICMT Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys278

Other Protein References for ICMT Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for ICMT Gene

Graphical View of Domain Structure for InterPro Entry

O60725

UniProtKB/Swiss-Prot:

ICMT_HUMAN
Family:
  • Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.:
    • O60725
genes like me logo Genes that share domains with ICMT: view

No data available for Gene Families for ICMT Gene

Function for ICMT Gene

Molecular function for ICMT Gene

UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.
UniProtKB/Swiss-Prot Function: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues

Enzyme Numbers (IUBMB) for ICMT Gene

Gene Ontology (GO) - Molecular Function for ICMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003880 protein C-terminal carboxyl O-methyltransferase activity TAS 9614111
GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity IEA --
GO:0008140 cAMP response element binding protein binding IEA --
genes like me logo Genes that share ontologies with ICMT: view
genes like me logo Genes that share phenotypes with ICMT: view

Animal Models for ICMT Gene

MGI Knock Outs for ICMT:

No data available for Transcription Factor Targeting and HOMER Transcription for ICMT Gene

Localization for ICMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICMT Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ICMT Gene COMPARTMENTS Subcellular localization image for ICMT gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 2
cytosol 1
extracellular 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ICMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 9614111
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane TAS 10441503
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ICMT: view

Pathways for ICMT Gene

genes like me logo Genes that share pathways with ICMT: view

Pathways by source for ICMT Gene

Gene Ontology (GO) - Biological Process for ICMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0001889 liver development IEA --
GO:0006464 cellular protein modification process TAS 9614111
GO:0006479 protein methylation --
GO:0006481 C-terminal protein methylation IEA --
genes like me logo Genes that share ontologies with ICMT: view

Compounds for ICMT Gene

(2) HMDB Compounds for ICMT Gene

Compound Synonyms Cas Number PubMed IDs
S-Adenosylhomocysteine
  • (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine
979-92-0
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0

(7) Novoseek inferred chemical compound relationships for ICMT Gene

Compound -log(P) Hits PubMed IDs
cysmethynil 98.4 8
s-adenosylhomocysteine 81.8 4
s-adenosylmethionine 69.5 3
homocysteine 51.5 2
cysteine 35.8 2
genes like me logo Genes that share compounds with ICMT: view

Transcripts for ICMT Gene

Unigene Clusters for ICMT Gene

Isoprenylcysteine carboxyl methyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ICMT Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1:
SP2: -
SP3: -
SP4: - -

Relevant External Links for ICMT Gene

GeneLoc Exon Structure for
ICMT
ECgene alternative splicing isoforms for
ICMT

Expression for ICMT Gene

mRNA expression in normal human tissues for ICMT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ICMT Gene

SOURCE GeneReport for Unigene cluster for ICMT Gene Hs.515688

mRNA Expression by UniProt/SwissProt for ICMT Gene

O60725-ICMT_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.
genes like me logo Genes that share expressions with ICMT: view

No data available for mRNA differential expression in normal tissues for ICMT Gene

Orthologs for ICMT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ICMT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ICMT 35
  • 99.53 (n)
  • 99.65 (a)
ICMT 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ICMT 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ICMT 35
  • 92.61 (n)
  • 97.18 (a)
mouse
(Mus musculus)
Mammalia Icmt 35
  • 89.08 (n)
  • 96.13 (a)
Icmt 16
Icmt 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ICMT 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ICMT 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Icmt 35
  • 88.03 (n)
  • 95.07 (a)
chicken
(Gallus gallus)
Aves ICMT 35
  • 75.15 (n)
  • 77.74 (a)
ICMT 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397717 35
tropical clawed frog
(Silurana tropicalis)
Amphibia icmt 35
  • 70.48 (n)
  • 73.43 (a)
zebrafish
(Danio rerio)
Actinopterygii icmt 35
  • 63.71 (n)
  • 65.31 (a)
icmt 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001310 35
  • 52.52 (n)
  • 50.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta ste14 35
  • 54.74 (n)
  • 51.66 (a)
ste14 36
  • 46 (a)
OneToOne
CG11268 37
  • 49 (a)
worm
(Caenorhabditis elegans)
Secernentea F21F3.3 36
  • 33 (a)
OneToMany
M01E11.1 35
  • 51.58 (n)
  • 46.27 (a)
M01E11.1 36
  • 35 (a)
OneToMany
M01E11.1 37
  • 43 (a)
F21F3.3 37
  • 42 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR122C 35
  • 50.55 (n)
  • 37.91 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE14 35
  • 50.94 (n)
  • 42.45 (a)
STE14 36
  • 38 (a)
OneToOne
STE14 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A02167g 35
  • 50.08 (n)
  • 41.31 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons STE14A 35
  • 51.22 (n)
  • 45.83 (a)
rice
(Oryza sativa)
Liliopsida Os04g0602900 35
  • 52.89 (n)
  • 47.33 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00034 35
  • 48.97 (n)
  • 42.18 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mam4 35
  • 45.95 (n)
  • 41.26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10934 36
  • 39 (a)
OneToOne
Species with no ortholog for ICMT:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ICMT Gene

ENSEMBL:
Gene Tree for ICMT (if available)
TreeFam:
Gene Tree for ICMT (if available)

Paralogs for ICMT Gene

No data available for Paralogs for ICMT Gene

Variants for ICMT Gene

Sequence variations from dbSNP and Humsavar for ICMT Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2732 -- 6,223,538(+) TGAAC(A/G)TACAT utr-variant-3-prime
rs846106 -- 6,234,012(-) AATGA(A/G)CTGGG intron-variant
rs846107 -- 6,233,935(-) ggagg(C/T)ggagg intron-variant
rs846108 -- 6,233,332(-) TTTAT(A/G)AAGGA intron-variant
rs846109 -- 6,229,775(-) TTTTT(A/T)ATTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ICMT Gene

Variant ID Type Subtype PubMed ID
nsv871698 CNV Loss 21882294
nsv870945 CNV Loss 21882294
dgv119n71 CNV Loss 21882294
nsv831425 CNV Loss 17160897
dgv120n71 CNV Loss 21882294
dgv121n71 CNV Loss 21882294
dgv8n67 CNV Gain 20364138
nsv508825 CNV Insertion 20534489
nsv871569 CNV Loss 21882294
dgv122n71 CNV Loss 21882294
dgv123n71 CNV Loss 21882294
nsv871385 CNV Loss 21882294

Relevant External Links for ICMT Gene

HapMap Linkage Disequilibrium report
ICMT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICMT Gene

Disorders for ICMT Gene

(4) Novoseek inferred disease relationships for ICMT Gene

Disease -log(P) Hits PubMed IDs
hyperhomocysteinemia 52.6 1
necrosis 0 2
tumors 0 2
cancer 0 3

Relevant External Links for ICMT

Genetic Association Database (GAD)
ICMT
Human Genome Epidemiology (HuGE) Navigator
ICMT
genes like me logo Genes that share disorders with ICMT: view

No data available for UniProtKB/Swiss-Prot for ICMT Gene

Publications for ICMT Gene

  1. Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. (PMID: 9614111) Dai Q. … Philips M.R. (J. Biol. Chem. 1998) 2 3 4 23
  2. Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe. (PMID: 19158273) Wright L.P. … Philips M.R. (Mol. Cell. Biol. 2009) 3 4 23
  3. Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis. (PMID: 12631708) Kramer K. … Rounds S. (Mol. Biol. Cell 2003) 3 23
  4. Prenylcysteine carboxymethyltransferase type III activity is decreased in retinoic acid-treated SH-SY5Y neuroblastoma cells. (PMID: 11906819) Van Dessel G.A. … Lagrou A.R. (Int. J. Biochem. Cell Biol. 2002) 3 23
  5. Role of isoprenylcysteine carboxyl methyltransferase in tumor necrosis factor-alpha stimulation of expression of vascular cell adhesion molecule-1 in endothelial cells. (PMID: 12006387) Ahmad M. … Alexander R.W. (Arterioscler. Thromb. Vasc. Biol. 2002) 3 23

Products for ICMT Gene

  • Addgene plasmids for ICMT

Sources for ICMT Gene

Back to Top

Content