Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ICMT Gene

Aliases for ICMT Gene

  • Isoprenylcysteine Carboxyl Methyltransferase 2 3 5
  • Protein-S-Isoprenylcysteine O-Methyltransferase 2 3
  • Prenylated Protein Carboxyl Methyltransferase 3 4
  • Prenylcysteine Carboxyl Methyltransferase 3 4
  • EC 2.1.1.100 4 61
  • PCCMT 3 4
  • PPMT 3 4
  • Isoprenylcysteine Carboxylmethyltransferase 4
  • MSTP098 3
  • HSTE14 3
  • MST098 3
  • PCMT 3

External Ids for ICMT Gene

Previous GeneCards Identifiers for ICMT Gene

  • GC01M005857
  • GC01M006090
  • GC01M005990
  • GC01M006215
  • GC01M005429

Summaries for ICMT Gene

Entrez Gene Summary for ICMT Gene

  • This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ICMT Gene

ICMT (Isoprenylcysteine Carboxyl Methyltransferase) is a Protein Coding gene. Diseases associated with ICMT include Legionaire Disease and Hallermann-Streiff Syndrome. Among its related pathways are G-protein signaling_H-RAS regulation pathway and Metabolism of proteins. GO annotations related to this gene include cAMP response element binding protein binding and protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity.

UniProtKB/Swiss-Prot for ICMT Gene

  • Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.

Gene Wiki entry for ICMT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICMT Gene

Genomics for ICMT Gene

Regulatory Elements for ICMT Gene

Enhancers for ICMT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F006222 0.2 ENCODE 20.1 +13.1 13122 1.6 ELF3 MAZ SAP130 SP5 NFIA ARID4B ZNF644 ZNF48 ZFHX2 POLR2A ICMT HES3 CHD5 LINC00337 RPL22
GH01F006218 0.2 ENCODE 20.1 +15.5 15546 2.9 ELF3 ATF1 PKNOX1 ARID4B SIN3A RAD21 THRB ZNF48 ZNF121 RCOR1 ICMT HES3 CHD5 LINC00337 RPL22
GH01F006233 0.5 ENCODE 19 +1.0 994 3.4 ATF1 PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 BRCA1 ZNF2 YY1 ICMT HES3 LINC00337 ZBTB48 GPR153 RNF207 RPL22
GH01F006259 1.5 FANTOM5 Ensembl ENCODE 18.6 -26.0 -26015 4.6 PKNOX1 ATF1 CREB3L1 ARID4B SIN3A BRCA1 GLIS2 KLF7 ZNF263 SP3 GPR153 ICMT LINC00337 RPL22 CHD5 LOC102724450 RNF207 THAP3 GC01P006262 ENSG00000271746
GH01F006223 0.4 ENCODE 13 +11.1 11072 1.9 ZFHX2 GLIS2 POLR2A GLIS1 EGR2 ICMT CHD5 RPL22
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ICMT on UCSC Golden Path with GeneCards custom track

Promoters for ICMT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001516966 184 2000 ARNT CREB3L1 SIN3A FEZF1 BRCA1 ZNF2 YY1 ZNF121 GTF3C2 GLIS2

Genomic Location for ICMT Gene

Chromosome:
1
Start:
6,221,193 bp from pter
End:
6,235,984 bp from pter
Size:
14,792 bases
Orientation:
Minus strand

Genomic View for ICMT Gene

Genes around ICMT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICMT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICMT Gene

Proteins for ICMT Gene

  • Protein details for ICMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60725-ICMT_HUMAN
    Recommended name:
    Protein-S-isoprenylcysteine O-methyltransferase
    Protein Accession:
    O60725
    Secondary Accessions:
    • Q6FHT0

    Protein attributes for ICMT Gene

    Size:
    284 amino acids
    Molecular mass:
    31938 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for ICMT Gene

Selected DME Specific Peptides for ICMT Gene

Post-translational modifications for ICMT Gene

  • Ubiquitination at Lys 278
  • Modification sites at PhosphoSitePlus

Other Protein References for ICMT Gene

Domains & Families for ICMT Gene

Graphical View of Domain Structure for InterPro Entry

O60725

UniProtKB/Swiss-Prot:

ICMT_HUMAN :
  • Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
Family:
  • Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
genes like me logo Genes that share domains with ICMT: view

No data available for Gene Families for ICMT Gene

Function for ICMT Gene

Molecular function for ICMT Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.
UniProtKB/Swiss-Prot Function:
Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.

Enzyme Numbers (IUBMB) for ICMT Gene

Gene Ontology (GO) - Molecular Function for ICMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003880 protein C-terminal carboxyl O-methyltransferase activity TAS 9614111
GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity IEA,TAS --
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with ICMT: view
genes like me logo Genes that share phenotypes with ICMT: view

Animal Models for ICMT Gene

MGI Knock Outs for ICMT:

Animal Model Products

  • Taconic Biosciences Mouse Models for ICMT

miRNA for ICMT Gene

miRTarBase miRNAs that target ICMT

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ICMT

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ICMT Gene

Localization for ICMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICMT Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ICMT Gene COMPARTMENTS Subcellular localization image for ICMT gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
cytosol 1
extracellular 1
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ICMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA 9614111
GO:0005789 endoplasmic reticulum membrane IEA,TAS --
GO:0016020 membrane IEA,TAS 10441503
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ICMT: view

Pathways & Interactions for ICMT Gene

genes like me logo Genes that share pathways with ICMT: view

Gene Ontology (GO) - Biological Process for ICMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 9614111
GO:0006481 C-terminal protein methylation IEA --
GO:0006612 protein targeting to membrane TAS 9614111
GO:0032259 methylation IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ICMT: view

No data available for SIGNOR curated interactions for ICMT Gene

Drugs & Compounds for ICMT Gene

(4) Drugs for ICMT Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0

(3) Additional Compounds for ICMT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ICMT: view

Transcripts for ICMT Gene

Unigene Clusters for ICMT Gene

Isoprenylcysteine carboxyl methyltransferase:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ICMT

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ICMT Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1:
SP2: -
SP3: -
SP4: - -

Relevant External Links for ICMT Gene

GeneLoc Exon Structure for
ICMT
ECgene alternative splicing isoforms for
ICMT

Expression for ICMT Gene

mRNA expression in normal human tissues for ICMT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ICMT Gene

This gene is overexpressed in Lung (25.4) and Placenta (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ICMT Gene



Protein tissue co-expression partners for ICMT Gene

NURSA nuclear receptor signaling pathways regulating expression of ICMT Gene:

ICMT

SOURCE GeneReport for Unigene cluster for ICMT Gene:

Hs.515688

mRNA Expression by UniProt/SwissProt for ICMT Gene:

O60725-ICMT_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.
genes like me logo Genes that share expression patterns with ICMT: view

Primer Products

No data available for mRNA differential expression in normal tissues for ICMT Gene

Orthologs for ICMT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ICMT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ICMT 34 35
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia ICMT 34
  • 92.61 (n)
mouse
(Mus musculus)
Mammalia Icmt 34 16 35
  • 89.08 (n)
rat
(Rattus norvegicus)
Mammalia Icmt 34
  • 88.03 (n)
cow
(Bos Taurus)
Mammalia ICMT 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ICMT 35
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ICMT 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves ICMT 34 35
  • 75.15 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia icmt 34
  • 70.48 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC397717 34
zebrafish
(Danio rerio)
Actinopterygii icmt 34 35
  • 63.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta ste14 34 35
  • 54.74 (n)
CG11268 36
  • 49 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001310 34
  • 52.52 (n)
worm
(Caenorhabditis elegans)
Secernentea M01E11.1 36 34 35
  • 51.58 (n)
F21F3.3 36 35
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE14 34 35 37
  • 50.94 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR122C 34
  • 50.55 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A02167g 34
  • 50.08 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons STE14A 34
  • 51.22 (n)
rice
(Oryza sativa)
Liliopsida Os04g0602900 34
  • 52.89 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00034 34
  • 48.97 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mam4 34
  • 45.95 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10934 35
  • 39 (a)
OneToOne
Species where no ortholog for ICMT was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ICMT Gene

ENSEMBL:
Gene Tree for ICMT (if available)
TreeFam:
Gene Tree for ICMT (if available)

Paralogs for ICMT Gene

No data available for Paralogs for ICMT Gene

Variants for ICMT Gene

Sequence variations from dbSNP and Humsavar for ICMT Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1059867 -- 6,221,794(-) GAGGT(C/T)GCGGG intron-variant, utr-variant-3-prime
rs1064721 -- 6,221,317(-) TGAAC(A/G)GAGTA intron-variant, utr-variant-3-prime
rs1064729 -- 6,221,253(-) TTTTC(A/T)TTCAC downstream-variant-500B, utr-variant-3-prime
rs11121506 -- 6,225,985(+) aagta(A/G)ctggg intron-variant
rs111395730 -- 6,229,392(+) AGAAT(A/C)GCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ICMT Gene

Variant ID Type Subtype PubMed ID
dgv28n106 CNV deletion 24896259
dgv8n67 CNV gain 20364138
nsv1076987 CNV deletion 25765185
nsv1119659 CNV deletion 24896259
nsv1119660 CNV deletion 24896259
nsv508825 CNV insertion 20534489
nsv545236 CNV loss 21841781
nsv831425 CNV loss 17160897

Variation tolerance for ICMT Gene

Residual Variation Intolerance Score: 56.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ICMT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ICMT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICMT Gene

Disorders for ICMT Gene

MalaCards: The human disease database

(2) MalaCards diseases for ICMT Gene - From: DISEASES

Disorder Aliases PubMed IDs
legionaire disease
  • legionnaires' disease
hallermann-streiff syndrome
  • francois dyscephalic syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ICMT in MalaCards View complete list of genes associated with diseases

Relevant External Links for ICMT

Genetic Association Database (GAD)
ICMT
Human Genome Epidemiology (HuGE) Navigator
ICMT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ICMT
genes like me logo Genes that share disorders with ICMT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ICMT Gene

Publications for ICMT Gene

  1. Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. (PMID: 9614111) Dai Q. … Philips M.R. (J. Biol. Chem. 1998) 2 3 4 22 64
  2. Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe. (PMID: 19158273) Wright L.P. … Philips M.R. (Mol. Cell. Biol. 2009) 3 4 22 64
  3. Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study. (PMID: 19841875) Fontaine-Bisson B. … Morange P.E. (J. Mol. Med. 2010) 3 46 64
  4. An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). (PMID: 19161160) Franke B. … Blom H.J. (Birth Defects Res. Part A Clin. Mol. Teratol. 2009) 3 46 64
  5. Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration. (PMID: 19651782) Cushman I. … Casey P.J. (J. Biol. Chem. 2009) 3 22 64

Products for ICMT Gene

Sources for ICMT Gene

Content
Loading form....