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ICMT Gene

protein-coding GIFtS: 59

GC01M006215

isoprenylcysteine carboxyl methyltransferase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.1.1.100 ^³
HSTE14 ^¹, ²
MGC39955 ^²
MST098 ^²
MSTP098 ^²
OTTHUMP00000001381 ^²
PCCMT ^¹, ², ³
PCMT ^²
PPMT ^¹, ², ³
pcCMT ^³

Descriptions
Isoprenylcysteine carboxylmethyltransferase ^³
Prenylated protein carboxyl methyltransferase ^², ³
Prenylcysteine carboxyl methyltransferase ^², ³
isoprenylcysteine carboxyl methyltransferase ^²
protein-S isoprenylcysteine O-methyltransferase ^²

External Ids
HGNC: 5350¹
Entrez Gene: 23463²
UniProtKB: O60725³
Ensembl: ENSG00000116237⁷

Search outside databases for aliases for ICMT gene

Previous GC identifers: GC01M005857 GC01M006090 GC01M005990

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ICMT:

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated

C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane.

This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other

transcript variants, but the biological validity of those transcripts has not been determined.

[provided by RefSeq]

UniProtKB/Swiss-Prot: ICMT_HUMAN, O60725

Function: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine

residues

Gene Wiki entry for ICMT

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ICMT gene

Entrez Gene cytogenetic band: 1p36.21 Ensembl cytogenetic band: 1p36.31 HGNC cytogenetic band: 1p36

ICMT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M006215: (about GC identifiers)

Start:	6,203,840 bp from pter
End:	6,218,631 bp from pter
Size:	14,792 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_021937.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ICMT_HUMAN, O60725 (See protein sequence)

Recommended Name: Protein-S-isoprenylcysteine O-methyltransferase

Size: 284 amino acids; 31938 Da

Cofactor: Divalent cations. Probably zinc (By similarity)

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein

REFSEQ proteins: NP_036537.1

ENSEMBL proteins:

ENSP00000354894 ENSP00000343552

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CMT)
	Human Recombinant Proteins from Abnova (ICMT)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	TAS	10441503
GO:0005783	endoplasmic reticulum	IDA	9614111
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for ICMT:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ICMT
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (CMT), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ICMT)
	Novus Biologicals Antibody for ICMT

Assays for ICMT:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O60725

ProtoNet protein and cluster: O60725

2 Blocks protein families:

IPB007269 Isoprenylcysteine carboxyl methyltransferase

IPB011024 Gamma-crystallin related

UniProtKB/Swiss-Prot: ICMT_HUMAN, O60725

Similarity: Belongs to the isoprenylcysteine O-methyltransferase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ICMT)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ICMT)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_012405

Applied Biosystems Silencer® siRNAs for ICMT

Sigma-Aldrich siRNA for ICMT

Sigma-Aldrich shRNA for ICMT

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ICMT
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_012405
Myc/DDK tagged cDNA clone in CMV expression vector: NM_012405
untagged cDNA clone in CMV expression vector: NM_012405

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_012405

UniProtKB/Swiss-Prot: ICMT_HUMAN, O60725

Function: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine

residues

Catalytic activity: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine =

S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester

Enzyme Number (IUBMB): EC 2.1.1.100

8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Icmt):

cellular	embryogenesis	growth/size	hematopoietic system	lethality-prenatal/perinatal
liver/biliary system	nervous system	normal

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004671	protein-S-isoprenylcysteine O-methyltransferase activity	IEA	--
GO:0008140	cAMP response element binding protein binding	IEA	--
GO:0008168	methyltransferase activity	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for ICMT (Your Favorite Gene powered by Ingenuity)

Aldosterone Signaling in Epithelial Cells

GeneDecks ICMT for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ICMT

5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001701	in utero embryonic development	IEA	--
GO:0001889	liver development	IEA	--
GO:0006464	protein modification process	TAS	9614111
GO:0006481	C-terminal protein amino acid methylation	TAS	10441503
GO:0006612	protein targeting to membrane	TAS	9614111

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ICMT
5 Novoseek chemical compound relationships for ICMT gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cysmethynil	98.00	12	17209565 (2), 15784746 (2), 16757321 (1), 19157999 (1) (see all 5)
s-adenosylhomocysteine	82.30	5	17360897 (2), 12631708 (1), 12750467 (1)
s-adenosylmethionine	70.13	4	12631708 (1), 17360897 (1), 15625008 (1)
homocysteine	52.52	3	12750467 (1), 17360897 (1)
indole	34.15	3	17209565 (3)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ICMT)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ICMT)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_012405

Sigma-Aldrich siRNA for ICMT

Sigma-Aldrich shRNA for ICMT

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_012405

REFSEQ mRNAs for ICMT gene:

NM_012405.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_012405

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012405
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_012405
                                 untagged cDNA clone in CMV expression vector: NM_012405

Additional cDNA sequence:

AF173157.1 BC028168.1 CR541671.1 CR541711.1 CR595162.1 CR605804.1

16 DOTS entries:

DT.100790533 DT.87017640 DT.100790540 DT.86855797 DT.95345873 DT.100790531 DT.95343582 DT.100790535

DT.121366499 DT.91771617 DT.40109201 DT.40109202 DT.86840009 DT.100029749 DT.91749368 DT.95283915

24/374 AceView cDNA sequences (see all 374 ):

CB048275 AW779430 AA984028 BU617580 AI304898 W78108 CR541711 AI222981

AL553748 AW169707 AW612700 BF001263 CA390765 CA429871 BU955941 BU617626

CB160354 NM_170705 BM771396 AI244487 BQ045349 BM709703 BE740204 BU839281

highest scoring ESTs for ICMT:

AL513958 BC028168 BI464077 BI919113 BM546276 BM564792 BP429984 BU160832 BU501528 CA390765

Unigene Cluster for ICMT:

Isoprenylcysteine carboxyl methyltransferase

Hs.515688 [show with all ESTs]

Unigene Representative Sequence: NM_012405

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ICMT

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7a	·	7b	·	7c	·	7d
SP1:
SP2:							-
SP3:							-
SP4:							-		-

About this scheme

ECgene alternative splicing isoforms for ICMT

2 Ensembl transcripts including schematic representations:

ENST00000362035 ENST00000343813

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ICMT expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ICMT

¹ / ² / ³

7 probe-sets matching ICMT gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41775_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AF064084	0.60	1.00	0.82	1
201609_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL578502	0.40	1.00	0.76	1
201611_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_012405	0.60	1.00	0.82	1
201610_at*²^{, 3}	U133-A	NULL	0.00	0.00	--	--	AF064084	0.60	1.00	0.82	1
201609_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201611_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201610_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGTTTGGAAG

SOURCE GeneReport for Unigene cluster: Hs.515688
Expression variation in blood from EXPOLDB for ICMT
UniProtKB/Swiss-Prot: ICMT_HUMAN, O60725
Tissue specificity: Ubiquitously expressed. Expressed at higher levels in the cerebellum and
putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine
neurons

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ICMT gene from 5/19 species (see all 19 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ICMT¹	--	isoprenylcysteine carboxyl methyltransferase	92.61(n) 97.18(a)	489628 XM_546748.2 XP_546748.1
chimpanzee (Pan troglodytes)	ICMT¹	--	isoprenylcysteine carboxyl methyltransferase	99.53(n) 99.65(a)	469782 XM_525166.2 XP_525166.2
rat (Rattus norvegicus)	Icmt¹	--	isoprenylcysteine carboxyl methyltransferase	91.23(n) 96.84(a)	170818 NM_133310.1 NP_579844.1
mouse (Mus musculus)	Icmt^{1, 5}	4⁵	isoprenylcysteine carboxyl methyltransferase^{1, 5}	89.08(n)¹ 96.13(a)¹	57295¹ NM_133788.1¹ NP_598549.1¹ AA022288⁵ AA387313⁵ (see all 23)
chicken (Gallus gallus)	ICMT¹	--	isoprenylcysteine carboxyl methyltransferase	75.15(n) 77.74(a)	419373 NM_001006298.1 NP_001006298.1

About this table Species with no ortholog for ICMT

ENSEMBL Gene Tree for ICMT

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/86 NCBI SNPs in ICMT are shown (see all 86 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 44)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1802353^1,2	A,C,F,H	6207267(-)	`ACACAG/AACCGC`	1	--	ut3¹ ese³		9		EA EU WA	2332
--	rs12070839^1,2	A,C,F,H	6205649(+)	`GGATCC/ATTTAC`	1	--	ut3¹		4		EU EA WA	412
--	rs9970334^1,2	A,C	6218825(+)	`GGAAGG/TGGTGG`	1	--	ng3¹		0	--	--	--	--
	rs2206540^1,2	C	6220460(-)	`GCTACC/TTGAGG`	1	--	ng3¹		0	--	--	--	--
	rs3747976^1,2	H	6207044(-)	`TACACG/AATTTG`	1	--	ut3¹ ese³		5		EA EU WA	1918
	rs35465282^1,2	F	6214657(+)	`TGTACC/TACGTG`	1	V/V	syn¹		1		NA	70
	rs4908541^1,2	C,F,H	6214397(+)	`TACCTA/GTTATT`	1	--	int¹		4		EU EA WA	412
	rs846108^1,2	C,H	6215979(-)	`TTTATA/GAAGGA`	1	--	int¹		5		MN EU EA WA	600
	rs12073932^1,2	F,H	6216477(+)	`AAGGGG/ACTGtt`	1	--	int¹		4		EU EA WA	388
--	rs846106^1,2	A,C	6216659(-)	`AATGAA/GCTGGG`	1	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for ICMT (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605851

4 Novoseek disease relationships for ICMT gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hyperhomocysteinemia	53.43	1	17360897 (1)
necrosis	0.00	2	12631708 (1), 12006387 (1)
cancer	0.00	3	17964784 (1), 18466935 (1), 15784746 (1)
tumors	0.00	2	12631708 (1), 12006387 (1)

About this table

Human Genome Epidemiology Navigator: ICMT (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/60 PubMed articles for ICMT gene (see all 60 ):

Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. (PubMed id 9614111)^{1, 2, 3, 4} Dai Q.... Philips M.R. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1. (PubMed id 10649571)^{3, 4} Lin X.... Zoghbi H.Y. (2000)
The carboxyl methyltransferase modifying G proteins is a metalloenzyme. (PubMed id 10441503)^{2, 3} Desrosiers R.R....Beliveau R. (1999)
Inhibition of ICMT induces endothelial cell apoptosis through GRP94. (PubMed id 17347446)^{1, 3} Lu Q....Rounds S. (2007)
Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis. (PubMed id 12631708)^{1, 3} Kramer K....Rounds S. (2003)
Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate. (PubMed id 12750467)^{1, 3} Winter-Vann A.M....Casey P.J. (2003)
Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe. (PubMed id 19158273)^{1, 3} Wright L.P....Philips M.R. (2009)
Role of isoprenylcysteine carboxyl methyltransferase in tumor necrosis factor-alpha stimulation of expression of vascular cell adhesion molecule-1 in endothelial cells. (PubMed id 12006387)^{1, 3} Ahmad M....Alexander R.W. (2002)
Prenylcysteine carboxymethyltransferase type III activity is decreased in retinoic acid-treated SH-SY5Y neuroblastoma cells. (PubMed id 11906819)^{1, 3} Van Dessel G.A....Lagrou A.R. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 23463	HGNC: 5350	AceView: ICMT	Ensembl:ENSG00000116237	euGenes: HUgn23463
ECgene: ICMT	H-InvDB: ICMT

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ICMT
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ICMT:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ICMT-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ICMT		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ICMT		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ICMT)
	Antibodies (ICMT)
	Chimera RNAi (ICMT)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (CMT)
	Antibodies (CMT)

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Search Tocris compounds for ICMT

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ICMT

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ICMT Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for ICMT

Summaries
for ICMT

Genomic Location
for ICMT

Proteins
for ICMT

Protein Domains/
Families
for ICMT

Gene Function
for ICMT

Pathways & Interactions
for ICMT

Drugs & Compounds
for ICMT

Transcripts
for ICMT

Expression
for ICMT

Orthologs
for ICMT

Paralogs
for ICMT

SNPs/Variants
for ICMT

Disorders & Mutations
for ICMT

Medical News
for ICMT

Publications
for ICMT

Search for ICMT

Genome Databases showing ICMT

Other Databases showing ICMT

Specialized Databases showing ICMT

Licensable Technologies
for ICMT

Services
for ICMT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ICMT Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor ICMT

Summariesfor ICMT

Genomic Locationfor ICMT

Proteinsfor ICMT

Protein Domains/Familiesfor ICMT

Gene Functionfor ICMT

Pathways & Interactionsfor ICMT

Drugs & Compoundsfor ICMT

Transcriptsfor ICMT

Expression for ICMT

Orthologsfor ICMT

Paralogsfor ICMT

SNPs/Variantsfor ICMT

Disorders & Mutationsfor ICMT

Medical Newsfor ICMT

Publicationsfor ICMT

Search for ICMT

Genome Databases showing ICMT

Other Databases showing ICMT

Specialized Databases showing ICMT

Licensable Technologiesfor ICMT

Servicesfor ICMT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ICMT

Summaries
for ICMT

Genomic Location
for ICMT

Proteins
for ICMT

Protein Domains/
Families
for ICMT

Gene Function
for ICMT

Pathways & Interactions
for ICMT

Drugs & Compounds
for ICMT

Transcripts
for ICMT

Expression
for ICMT

Orthologs
for ICMT

Paralogs
for ICMT

SNPs/Variants
for ICMT

Disorders & Mutations
for ICMT

Medical News
for ICMT

Publications
for ICMT

Licensable Technologies
for ICMT

Services
for ICMT