Aliases for ICMT Gene
Aliases for ICMT Gene
External Ids for ICMT Gene
- HGNC: 5350
- Entrez Gene: 23463
- Ensembl: ENSG00000116237
- OMIM: 605851
- UniProtKB: O60725
Previous GeneCards Identifiers for ICMT Gene
- GC01M005857
- GC01M006090
- GC01M005990
- GC01M006215
- GC01M005429
Summaries for ICMT Gene
-
This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for ICMT Gene
ICMT (Isoprenylcysteine Carboxyl Methyltransferase) is a Protein Coding gene. Diseases associated with ICMT include Legionaire Disease. Among its related pathways are Gamma carboxylation, hypusine formation and arylsulfatase activation and G-protein signaling_H-RAS regulation pathway. GO annotations related to this gene include cAMP response element binding protein binding and protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity.
UniProtKB/Swiss-Prot for ICMT Gene
-
Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICMT Gene
Genomics for ICMT Gene
Regulatory Elements for ICMT Gene
Enhancers for ICMT Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around ICMT on UCSC Golden Path with GeneCards custom track
Promoters for ICMT Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around ICMT on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ICMT gene promoter:
Regulatory Element Products
Genomic Location for ICMT Gene
- Chromosome:
- 1
- Start:
- 6,221,193 bp from pter
- End:
- 6,235,984 bp from pter
- Size:
- 14,792 bases
- Orientation:
- Minus strand
Genomic View for ICMT Gene
Genes around ICMT on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p36.31 by Ensembl
- 1p36.21 by Entrez Gene
- 1p36 by HGNC
ICMT Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ICMT Gene
Proteins for ICMT Gene
-
Protein details for ICMT Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60725-ICMT_HUMAN
- Recommended name:
- Protein-S-isoprenylcysteine O-methyltransferase
- Protein Accession:
- O60725
- Q6FHT0
Protein attributes for ICMT Gene
- Size:
- 284 amino acids
- Molecular mass:
- 31938 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
- No Data Available
Protein Expression for ICMT Gene
Selected DME Specific Peptides for ICMT Gene
Post-translational modifications for ICMT Gene
Other Protein References for ICMT Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for ICMT
-
Custom Antibody ServicesOriGene Antibodies for ICMT
- Novus Biologicals Antibodies for ICMT
- Abcam antibodies for CMT
- Invitrogen Antibodies for ICMT
- antibodies-online Antibodies for ICMT: See all 46
- GeneTex ICMT antibody for ICMT
-
Santa Cruz Biotechnology (SCBT) Antibodies for ICMT
Protein Products
-
OriGene Purified Proteins for ICMT
- Search Origene for MassSpec and Protein Over-expression Lysates for ICMT
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- antibodies-online Proteins for ICMT: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ICMT
- Abcam proteins for CMT
Assay Products
- antibodies-online Kits for ICMT: See all 3
Domains & Families for ICMT Gene
Protein Domains for ICMT Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ICMT Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O60725UniProtKB/Swiss-Prot:
ICMT_HUMAN :- Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
- Family:
-
- Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
No data available for Gene Families for ICMT Gene
Function for ICMT Gene
Molecular function for ICMT Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.
- UniProtKB/Swiss-Prot Function:
- Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
Enzyme Numbers (IUBMB) for ICMT Gene
- EC 2.1.1.100 63 4
Phenotypes for ICMT Gene
- MGI mutant phenotypes for ICMT:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for ICMT:
-
- Increased vaccinia virus (VACV) infection
- Synthetic lethal with Ras
- Decreased ionizing radiation sensitivity
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased shRNA abundance (Z-score > 2)
- Decreased viability after Maraba virus infection
- Decreased viability
- Decreased shRNA abundance
- Decreased shRNA abundance (Z-score < -2)
Animal Model Products
-
Taconic Biosciences Mouse Models for ICMT
-
ViGene Biosciences lentiviral particle packaged cDNA for ICMT gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ICMT gene
- Search ViGene Biosciences for ICMT
CRISPR Products
-
OriGene CRISPR knockouts for ICMT
-
Santa Cruz Biotechnology (SCBT) CRISPR for ICMT
- GenScript: Design CRISPR guide RNA sequences for ICMT
miRNA for ICMT Gene
- miRTarBase miRNAs that target ICMT
-
- hsa-mir-130b-3p (MIRT020175)
- hsa-mir-124-3p (MIRT022702)
- hsa-mir-93-5p (MIRT028069)
- hsa-mir-26b-5p (MIRT029560)
- hsa-mir-331-3p (MIRT043333)
- hsa-mir-1260b (MIRT052699)
- hsa-mir-4433b-5p (MIRT074491)
- hsa-mir-4475 (MIRT283557)
- hsa-mir-6504-3p (MIRT343357)
- hsa-mir-210-3p (MIRT440033)
- hsa-mir-218-5p (MIRT440471)
- hsa-mir-4436b-3p (MIRT475394)
- hsa-mir-6864-5p (MIRT475395)
- hsa-mir-3650 (MIRT475396)
- hsa-mir-6499-3p (MIRT475397)
- hsa-mir-873-5p (MIRT475398)
- hsa-mir-3179 (MIRT475399)
- hsa-mir-7515 (MIRT475400)
- hsa-mir-7845-5p (MIRT475401)
- hsa-mir-940 (MIRT475402)
- hsa-mir-6893-5p (MIRT475403)
- hsa-mir-6808-5p (MIRT475404)
- hsa-mir-3910 (MIRT475405)
- hsa-mir-3714 (MIRT475406)
- hsa-mir-506-3p (MIRT475407)
- hsa-mir-106b-5p (MIRT475408)
- hsa-mir-17-5p (MIRT475409)
- hsa-mir-20a-5p (MIRT475410)
- hsa-mir-20b-5p (MIRT475411)
- hsa-mir-519d-3p (MIRT475412)
- hsa-mir-526b-3p (MIRT475413)
- hsa-mir-106a-5p (MIRT475414)
- hsa-mir-6807-5p (MIRT523047)
- hsa-mir-6888-3p (MIRT523048)
- hsa-mir-7151-3p (MIRT523049)
- hsa-mir-5095 (MIRT523050)
- hsa-mir-3120-5p (MIRT523051)
- hsa-mir-1292-3p (MIRT523052)
- hsa-mir-6850-3p (MIRT523053)
- hsa-mir-4438 (MIRT523054)
- hsa-mir-1260a (MIRT529513)
- hsa-mir-4433a-5p (MIRT529514)
- hsa-mir-219b-5p (MIRT529515)
- hsa-mir-5009-3p (MIRT529516)
- hsa-mir-1224-3p (MIRT529517)
- hsa-mir-6834-3p (MIRT529518)
- hsa-mir-501-5p (MIRT529519)
- hsa-mir-508-5p (MIRT529520)
- hsa-mir-3145-5p (MIRT529521)
- hsa-mir-4797-5p (MIRT529522)
- hsa-mir-520e (MIRT529523)
- hsa-mir-520d-3p (MIRT529524)
- hsa-mir-520c-3p (MIRT529525)
- hsa-mir-520b (MIRT529526)
- hsa-mir-520a-3p (MIRT529527)
- hsa-mir-373-3p (MIRT529528)
- hsa-mir-372-3p (MIRT529529)
- hsa-mir-302e (MIRT529530)
- hsa-mir-302d-3p (MIRT529531)
- hsa-mir-302c-3p (MIRT529532)
- hsa-mir-302b-3p (MIRT529533)
- hsa-mir-302a-3p (MIRT529534)
- hsa-mir-519c-3p (MIRT529535)
- hsa-mir-519b-3p (MIRT529536)
- hsa-mir-519a-3p (MIRT529537)
miRNA Products
- Search ViGene Biosciences for ICMT
Clone Products
- OriGene clones in human for ICMT
- OriGene ORF clones in human,mouse,rat for ICMT
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Addgene plasmids for ICMT
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for ICMT gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ICMT gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ICMT gene
Flow Cytometry Products
No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ICMT Gene
Localization for ICMT Gene
Subcellular locations from UniProtKB/Swiss-Prot for ICMT Gene
- Endoplasmic reticulum membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| plasma membrane | 3 |
| cytosol | 1 |
| extracellular | 1 |
| golgi apparatus | 1 |
| lysosome | 1 |
| vacuole | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005789 | endoplasmic reticulum membrane | IEA,TAS | -- |
Pathways & Interactions for ICMT Gene
More details on SuperPathways for ICMTPathways by source for ICMT Gene
3 Reactome pathways for ICMT Gene
1 KEGG pathway for ICMT Gene
3 GeneGo (Thomson Reuters) pathways for ICMT Gene
Interacting Proteins for ICMT Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006464 | cellular protein modification process | TAS | 9614111 |
| GO:0046498 | S-adenosylhomocysteine metabolic process | IEA | -- |
No data available for SIGNOR curated interactions for ICMT Gene
Transcripts for ICMT Gene
mRNA/cDNA for ICMT Gene
- (3) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (374) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ICMT Gene
CRISPR Products
-
OriGene CRISPR knockouts for ICMT
-
Santa Cruz Biotechnology (SCBT) CRISPR for ICMT
- GenScript: Design CRISPR guide RNA sequences for ICMT
miRNA Products
- Search ViGene Biosciences for ICMT
Clone Products
- OriGene clones in human for ICMT
- OriGene ORF clones in human,mouse,rat for ICMT
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ICMT
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||
| SP4: | - | - |
Expression for ICMT Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Liver (Hepatobiliary System)
- Hepatoblasts Liver Bud
-
Epithelial Cells
- Hepatoblasts Liver Bud
- Eye (Sensory Organs)
-
Fibroblasts (Uncategorized)
This gene is overexpressed in Lung (25.4) and Placenta (9.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ICMT Gene
SOURCE GeneReport for Unigene cluster for ICMT Gene Hs.515688
mRNA Expression by UniProt/SwissProt for ICMT Gene
O60725-ICMT_HUMAN
Tissue specificity:
Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.
Primer Products
-
OriGene qPCR primer pairs and template standards for ICMT
-
OriGene qPCR primer pairs for ICMT
No data available for mRNA differential expression in normal tissues for ICMT Gene
Orthologs for ICMT Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | ICMT 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Icmt 35 |
|
||
| Icmt 16 |
|
||||
| Icmt 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | ICMT 35 |
|
||
| ICMT 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Icmt 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ICMT 36 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ICMT 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ICMT 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ICMT 35 |
|
||
| ICMT 36 |
|
OneToOne | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | icmt 35 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC397717 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | icmt 35 |
|
||
| icmt 36 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG11268 37 |
|
|
|
| ste14 35 |
|
||||
| ste14 36 |
|
OneToOne | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001310 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | F21F3.3 37 |
|
|
|
| M01E11.1 37 |
|
|
|||
| M01E11.1 35 |
|
||||
| F21F3.3 36 |
|
OneToMany | |||
| M01E11.1 36 |
|
OneToMany | |||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AAR122C 35 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A02167g 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | STE14 35 |
|
||
| STE14 36 |
|
OneToOne | |||
| STE14 38 |
|
|
|||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | STE14A 35 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os04g0602900 35 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU00034 35 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | mam4 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10934 36 |
|
OneToOne |
- Species with no ortholog for ICMT:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ICMT Gene
No data available for Paralogs for ICMT Gene
Variants for ICMT Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs2732 | -- | 6,223,538(+) | TGAAC(A/G)TACAT | utr-variant-3-prime | |
| rs846106 | -- | 6,234,012(-) | AATGA(A/G)CTGGG | intron-variant | |
| rs846107 | -- | 6,233,935(-) | ggagg(C/T)ggagg | intron-variant | |
| rs846108 | -- | 6,233,332(+) | TTTAT(A/C/G/T)AAGGA | intron-variant | |
| rs846109 | -- | 6,229,775(-) | TTTTT(A/T)ATTTA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv871698 | CNV | Loss | 21882294 |
| nsv870945 | CNV | Loss | 21882294 |
| dgv119n71 | CNV | Loss | 21882294 |
| nsv831425 | CNV | Loss | 17160897 |
| dgv120n71 | CNV | Loss | 21882294 |
| dgv121n71 | CNV | Loss | 21882294 |
| dgv8n67 | CNV | Gain | 20364138 |
| nsv508825 | CNV | Insertion | 20534489 |
| nsv871569 | CNV | Loss | 21882294 |
| dgv122n71 | CNV | Loss | 21882294 |
| dgv123n71 | CNV | Loss | 21882294 |
| nsv871385 | CNV | Loss | 21882294 |
Residual Variation Intolerance Score:
56.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.92;
35.73% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ICMT Gene
Disorders for ICMT Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| legionaire disease |
|
|
Search ICMT in MalaCards
View complete list of genes associated with diseases
Relevant External Links for ICMT
No data available for UniProtKB/Swiss-Prot and Genatlas for ICMT Gene
Publications for ICMT Gene
- Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. (PMID: 9614111) Dai Q. … Philips M.R. (J. Biol. Chem. 1998) 2 3 4 23 67
- Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe. (PMID: 19158273) Wright L.P. … Philips M.R. (Mol. Cell. Biol. 2009) 3 23
- Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration. (PMID: 19651782) Cushman I. … Casey P.J. (J. Biol. Chem. 2009) 3 23
- Inhibition of ICMT induces endothelial cell apoptosis through GRP94. (PMID: 17347446) Lu Q. … Rounds S. (Am. J. Respir. Cell Mol. Biol. 2007) 3 23
- Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis. (PMID: 12631708) Kramer K. … Rounds S. (Mol. Biol. Cell 2003) 3 23
Products for ICMT Gene
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- Custom Antibody ServicesOriGene Antibodies for ICMT
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- OriGene qPCR primer pairs for ICMT
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- GenScript: Design CRISPR guide RNA sequences for ICMT
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- CloneReady with Over 120,000 Genes
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- Novus Biologicals Antibodies for ICMT
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- Novus Biologicals
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- Abcam antibodies for CMT
- Abcam proteins for CMT
- Search for Assays for ICMT at Abcam
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- Taconic Biosciences Mouse Models for ICMT
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Addgene plasmids for ICMT
- antibodies-online Antibodies for ICMT: See all 46
- antibodies-online Kits for ICMT: See all 3
- antibodies-online Proteins for ICMT: See all 5
- Search antibodies-online for peptides
- GeneTex ICMT antibody for ICMT
- Search GeneTex for Proteins for ICMT
- ViGene Biosciences adenoviral particle packaged cDNA for ICMT gene
- ViGene Biosciences lentiviral particle packaged cDNA for ICMT gene
- ViGene Biosciences lentiviral particle packaged cDNA for ICMT gene
- ViGene Biosciences ready-to-package AAV shRNAs for ICMT gene
- ViGene Biosciences ready-to-package AAV shRNAs for ICMT gene
- ViGene Biosciences ready-to-package AAV shRNAs for ICMT gene
- Search ViGene Biosciences for ICMT
- Search ViGene Biosciences for ICMT
- Santa Cruz Biotechnology (SCBT) Antibodies for ICMT
- Search Santa Cruz Biotechnology (SCBT) for ICMT siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ICMT
Sources for ICMT Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
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