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Set Analyses:

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ICMT Gene

protein-coding GIFtS: 64
GCID: GC01M006282

Isoprenylcysteine Carboxyl Methyltransferase

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Isoprenylcysteine Carboxyl Methyltransferase¹ ²		HSTE14²
Protein-S-Isoprenylcysteine O-Methyltransferase¹ ²		MST098²
Prenylated Protein Carboxyl Methyltransferase² ³		MSTP098²
Prenylcysteine Carboxyl Methyltransferase² ³		PCMT²
PCCMT² ³		Protein-S Isoprenylcysteine O-Methyltransferase²
PPMT² ³		Isoprenylcysteine Carboxylmethyltransferase³
EC 2.1.1.100³ ⁸		pcCMT³

External Ids:	HGNC: 5350¹	Entrez Gene: 23463²	Ensembl: ENSG00000116237⁷	OMIM: 605851⁵	UniProtKB: O60725³

Export aliases for ICMT gene to outside databases

Previous GC identifers: GC01M005857 GC01M006090 GC01M005990 GC01M006215 GC01M005429

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ICMT Gene:

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine

residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the

endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity

of those transcripts has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for ICMT Gene:

ICMT (isoprenylcysteine carboxyl methyltransferase) is a protein-coding gene. Diseases associated with ICMT include legionnaires' disease, and hyperhomocysteinemia. GO annotations related to this gene include protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity and cAMP response element binding protein binding.

UniProtKB/Swiss-Prot: ICMT_HUMAN, O60725

Function: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues

Gene Wiki entry for ICMT Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000001.11 NT_032977.10 NC_018912.2

Regulatory elements:

Regulatory transcription factor binding sites in the ICMT gene promoter:
Max1 Bach2 NRSF form 1 NRSF form 2 COMP1 STAT3 ARP-1 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ICMT promoter sequence

Search Chromatin IP Primers for ICMT

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ICMT

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.21 Ensembl cytogenetic band: 1p36.31 HGNC cytogenetic band: 1p36

ICMT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ICMT gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M006282: view genomic region (about GC identifiers)

Start:	6,281,253 bp from pter	End:	6,296,044 bp from pter
Size:	14,792 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ICMT_HUMAN, O60725 (See protein sequence)

Recommended Name: Protein-S-isoprenylcysteine O-methyltransferase

Size: 284 amino acids; 31938 Da

Cofactor: Divalent cations. Probably zinc (By similarity)

Secondary accessions: Q6FHT0

Explore the universe of human proteins at neXtProt for ICMT: NX_O60725

Explore proteomics data for ICMT at MOPED

Post-translational modifications:

Ubiquitination² at Lys278

Modification sites at PhosphoSitePlus

Selected DME Specific Peptides for ICMT (O60725) (see all 6)

RHPSYVG

SFLLNHS

SLIHFFGE

GTQVMLCNP

See ICMT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_036537.1

ENSEMBL proteins:

ENSP00000343552 ENSP00000466222 ENSP00000467999 ENSP00000354894

ICMT Human Recombinant Protein Products:

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ICMT Antibody Products:

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	LSBio Antibodies in human, mouse, rat for ICMT

ICMT Assay Products:

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	Cloud-Clone Corp. ELISAs for ICMT Cloud-Clone Corp. CLIAs for ICMT

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:

IPR007269 ICMT_MeTrfase

IPR025770 PPMT_MeTrfase

Graphical View of Domain Structure for InterPro Entry O60725

ProtoNet protein and cluster: O60725

2 Blocks protein domains:

IPB007269 Isoprenylcysteine carboxyl methyltransferase

IPB011024 Gamma-crystallin related

UniProtKB/Swiss-Prot: ICMT_HUMAN, O60725

Similarity: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl

methyltransferase family

ICMT for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: ICMT_HUMAN, O60725

Function: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues

Catalytic activity: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine

+ protein C-terminal S-farnesyl-L-cysteine methyl ester

Enzyme Number (IUBMB): EC 2.1.1.100¹ ²

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003880	protein C-terminal carboxyl O-methyltransferase activity	TAS	9614111
GO:0004671	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity	IEA	--
GO:0008140	cAMP response element binding protein binding	IEA	--

ICMT for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ICMT:

Synthetic lethal with Ras

9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Icmt):

cellular	embryogenesis	growth/size/body	hematopoietic system	integument
liver/biliary system	mortality/aging	nervous system	normal

ICMT for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for ICMT: Icmt^tm1Hzo Icmt^tm1Sgy

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ICMT

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ICMT

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miRNA Products:		miRTarBase miRNAs that target ICMT: hsa-mir-1260b (MIRT052699), hsa-mir-331-3p (MIRT043333), hsa-mir-93-5p (MIRT028069), hsa-mir-124-3p (MIRT022702), hsa-mir-26b-5p (MIRT029560), hsa-mir-130b-3p (MIRT020175)

		Block miRNA regulation of human, mouse, rat ICMT using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate ICMT (see all 62):
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		Browse SwitchGear 3'UTR luciferase reporter plasmids

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICMT

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

ICMT_HUMAN, O60725: Endoplasmic reticulum membrane; Multi-pass membrane protein

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
endoplasmic reticulum	5
plasma membrane	2
cytosol	1
extracellular	1
golgi apparatus	1
lysosome	1

About this image

Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IDA	9614111
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0016020	membrane	TAS	10441503
GO:0016021	integral component of membrane	IEA	--

ICMT for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ICMT About

See pathways by source

SuperPath

Contained pathways About

Immune response Antigen presentation by MHC class II

G protein signaling N RAS regulation pathway

0.46

superpathway of cholesterol biosynthesis

Terpenoid backbone biosynthesis

0.34

G protein signaling K RAS regulation pathway

G protein signaling K RAS regulation pathway

G protein signaling H RAS regulation pathway

G protein signaling H RAS regulation pathway

Pathways by source See SuperPaths
Show all pathways

3 GeneGo (Thomson Reuters) Pathways for ICMT

	G-protein signaling H-RAS regulation pathway
	G-protein signaling K-RAS regulation pathway
	G-protein signaling N-RAS regulation pathway

1 Kegg Pathway (Kegg details for ICMT):

Terpenoid backbone biosynthesis

ICMT for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for ICMT
Interactions:

GeneGlobe Interaction Network for ICMT

STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

Selected Interacting proteins for ICMT (O60725³ ENSP00000343552⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RAC2	P15153³, ENSP00000249071⁴	I2D: score=3 STRING: ENSP00000249071
RHOA	P61586³, ENSP00000400175⁴	I2D: score=3 STRING: ENSP00000400175
HRAS	P01112³, ENSP00000309845⁴	I2D: score=2 STRING: ENSP00000309845
USO1	O60763³, ENSP00000411698⁴	I2D: score=1 STRING: ENSP00000411698
ZMPSTE24	O75844³, ENSP00000361845⁴	I2D: score=1 STRING: ENSP00000361845

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Gene Ontology (GO): Selected biological process terms (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001701	in utero embryonic development	IEA	--
GO:0001889	liver development	IEA	--
GO:0006464	cellular protein modification process	TAS	9614111
GO:0006479	protein methylation	--	--
GO:0006481	C-terminal protein methylation	TAS	10441503

ICMT for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for ICMT

2 HMDB Compounds for ICMT About this table

Compound	Synonyms	CAS #	PubMed Ids
S-Adenosylhomocysteine	(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)	979-92-0	--
S-Adenosylmethionine	(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)	29908-03-0	--

7 Novoseek inferred chemical compound relationships for ICMT gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cysmethynil	98.4	13	17209565 (2), 15784746 (2), 16757321 (1), 19157999 (1) (see all 6)
s-adenosylhomocysteine	81.8	5	17360897 (2), 12631708 (1), 12750467 (1)
s-adenosylmethionine	69.5	4	12631708 (1), 17360897 (1), 15625008 (1)
homocysteine	51.5	3	12750467 (1), 17360897 (1)
cysteine	35.8	4	16757321 (1), 15625008 (1)
indole	32.9	3	17209565 (3)
aspartate	4.56	2	11985579 (1), 10880963 (1)

ICMT for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ICMT gene (2 alternative transcripts):

NM_012405.3 NM_170705.1

Unigene Cluster for ICMT:

Isoprenylcysteine carboxyl methyltransferase

Hs.515688 [show with all ESTs]

Unigene Representative Sequence: NM_012405

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000343813(uc001amk.3 uc001aml.3) ENST00000495791 ENST00000489498

ENST00000474756 ENST00000362035

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		Selected qRT-PCR Assays for microRNAs that regulate ICMT (see all 62):
		hsa-miR-4328 hsa-let-7d hsa-miR-106a hsa-miR-16-1* hsa-miR-3653 hsa-miR-519a hsa-let-7g hsa-miR-3142

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		QuantiFast Probe-based Assays in human, mouse, rat ICMT

Additional mRNA sequence:

AF173157.1 BC028168.1 CR541671.1 CR541711.1

16 DOTS entries:

DT.100790533 DT.87017640 DT.100790540 DT.86855797 DT.95345873 DT.100790531 DT.95343582 DT.100790535

DT.121366499 DT.91771617 DT.40109201 DT.40109202 DT.86840009 DT.100029749 DT.91749368 DT.95283915

Selected AceView cDNA sequences (see all 374):

BU617580 AW779430 AU141081 AW612700 BE220666 AI214943 AI222981 CN481591

CA314834 BM995289 BM676563 W79933 CN479517 BM454345 AA487020 BQ045104

BM772715 BU157494 CK904501 AI085228 BU689969 CA309880 AW169707 BM709703

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ICMT About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7a	·	7b	·	7c	·	7d
SP1:
SP2:							-
SP3:							-
SP4:							-		-

ECgene alternative splicing isoforms for ICMT

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ICMT expression in normal human tissues (normalized intensities) ICMT embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GGTTTGGAAG

About this image

ICMT expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 5) fully expand


Epithelial Cells
Hepatoblasts Liver Bud

Liver (Hepatobiliary System)
Hepatoblasts Liver Bud

Eye (Sensory Organs)
Retina

Peripheral Nervous System (Nervous System)

Fibroblasts (Uncategorized)

ICMT Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ICMT Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.515688

UniProtKB/Swiss-Prot: ICMT_HUMAN, O60725

Tissue specificity: Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other

brain regions. Abundant expression seen in the Purkinje cells and pontine neurons

Custom PCR Arrays for ICMT

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		QuantiFast Probe-based Assays in human, mouse, rat ICMT

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICMT

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for ICMT gene from Selected species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	Icmt^{1 , 5}	isoprenylcysteine carboxyl methyltransferase^{1, 5}	89.08(n)¹ 96.13(a)¹	4 (83.02 cM)⁵ 57295¹ NM_133788.2¹ NP_598549.1¹ 152297227⁵
chicken (Gallus gallus)	Aves	ICMT¹	isoprenylcysteine carboxyl methyltransferase	75.15(n) 77.74(a)	419373 NM_001006298.1 NP_001006298.1
African clawed frog (Xenopus laevis)	Amphibia	LOC397717²	farnesyl cysteine carboxyl methyltransferase	73.58(n)	D87750.1
zebrafish (Danio rerio)	Actinopterygii	icmt¹	isoprenylcysteine carboxyl methyltransferase	63.71(n) 65.31(a)	550281 NM_001017618.1 NP_001017618.1
fruit fly (Drosophila melanogaster)	Insecta	CG11268³ ste14¹	protein-S-isoprenylcysteine O-methyltransferase³ isoprenylcysteine carboxylmethyltransferase¹	49(a)³ 54.74(n)¹ 51.66(a)¹	69F5³ 39478¹ NM_001274864.1¹ NP_001261793.1¹
worm (Caenorhabditis elegans)	Secernentea	M01E11.1^{1 , 3}	M01E11.1¹	43(a) (best of 2)³ 51.58(n)¹ 46.27(a)¹	I(5582106-5583267)³ 187374¹ NM_059234.4¹ NP_491635.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	STE14(YDR410C)⁴ STE14¹	Farnesyl cysteine-carboxyl methyltransferase, mediates more⁴ STE14¹	50.94(n)¹ 42.45(a)¹	4(1293091-1292372)⁴ 852019^{1, 4} NP_010698.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	STE14A¹	STE14A	51.22(n) 45.83(a)	832396 NM_122238.1 NP_197723.1
rice (Oryza sativa)	Liliopsida	Os04g0602900¹	Os04g0602900	52.89(n) 47.33(a)	4336894 NM_001060312.1 NP_001053777.1

ENSEMBL Gene Tree for ICMT (if available)
TreeFam Gene Tree for ICMT (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191483881^1,2		--	6281947(+)	`GACAGA/TACCTA`	1	--	ut3¹		0	--	--	--	--
rs182857230^1,2		--	6281973(+)	`TCTCCA/CCTTTA`	1	--	ut3¹		0	--	--	--	--
rs187079677^1,2		--	6282017(+)	`TTTTTC/TAAATC`	1	--	ut3¹		0	--	--	--	--
rs11538542^1,2	C,H	--	6282155(+)	`AAAAAG/AAAGTC`	1	--	ut3¹ ese³		2		NS NA	172
rs111517383^1,2	F	--	6282256(+)	`CGCGTG/AGATCA`	1	--	ut3¹		1		CSA	2
rs150391371^1,2		--	6282580(+)	`TCCCAC/TCATCC`	1	--	ut3¹		0	--	--	--	--
rs183421578^1,2		--	6282626(+)	`CAAGTC/TTTCCC`	1	--	ut3¹		0	--	--	--	--
rs74049509^1,2	C,F	--	6282679(+)	`TCCTGG/CGCTCC`	1	--	ut3¹		2		WA	120
rs187746028^1,2	C	--	6282887(+)	`AAGAAC/GTTTTC`	1	--	ut3¹		0	--	--	--	--
rs192302681^1,2		--	6282905(+)	`GAGCCA/GGGGCA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ICMT (6281253 - 6296044 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for ICMT (see all 12): About this table

Variant ID	Type	Subtype	PubMed ID
nsv508825	CNV	Insertion	20534489
nsv871698	CNV	Loss	21882294
dgv121n71	CNV	Loss	21882294
dgv120n71	CNV	Loss	21882294
dgv122n71	CNV	Loss	21882294
nsv870945	CNV	Loss	21882294
dgv123n71	CNV	Loss	21882294
nsv831425	CNV	Loss	17160897
nsv871385	CNV	Loss	21882294
nsv871569	CNV	Loss	21882294

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605851 OMIM disorders: --

14 diseases for ICMT: About MalaCards

legionnaires' disease hyperhomocysteinemia uremia spina bifida

spinocerebellar ataxia endometrial carcinoma ataxia liver disease

neuroblastoma endotheliitis alzheimer's disease melanoma

malaria neuronitis

ICMT for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

4 Novoseek inferred disease relationships for ICMT gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hyperhomocysteinemia	52.6	1	17360897 (1)
necrosis	0	2	12631708 (1), 12006387 (1)
tumors	0	2	12631708 (1), 12006387 (1)
cancer	0	3	17964784 (1), 18466935 (1), 15784746 (1)

Genetic Association Database (GAD): ICMT
Human Genome Epidemiology (HuGE) Navigator: ICMT (2 documents)

Export disorders for ICMT gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ICMT gene, integrated from 10 sources (see all 69):
(articles sorted by number of sources associating them with ICMT)

Utopia: connect your pdf to the dynamic
world of online information

Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. (PubMed id 9614111)^{1, 2, 3, 9} Dai Q.... Philips M.R. (J. Biol. Chem. 1998)
Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe. (PubMed id 19158273)^{1, 2, 9} Wright L.P.... Philips M.R. (Mol. Cell. Biol. 2009)
Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study. (PubMed id 19841875)^{1, 4} Fontaine-Bisson B....Morange P.E. (J. Mol. Med. 2010)
An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). (PubMed id 19161160)^{1, 4} Franke B....Blom H.J. (Birth Defects Res. Part A Clin. Mol. Teratol. 2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1. (PubMed id 10649571)^{1, 2} Lin X.... Zoghbi H.Y. (Nat. Neurosci. 2000)
The carboxyl methyltransferase modifying G proteins is a metalloenzyme. (PubMed id 10441503)^{1, 3} Desrosiers R.R....BAcliveau R. (Biochem. Biophys. Res. Commun. 1999)
Inhibition of ICMT induces endothelial cell apoptosis through GRP94. (PubMed id 17347446)^{1, 9} Lu Q....Rounds S. (Am. J. Respir. Cell Mol. Biol. 2007)
Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis. (PubMed id 12631708)^{1, 9} Kramer K....Rounds S. (Mol. Biol. Cell 2003)
Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate. (PubMed id 12750467)^{1, 9} Winter-Vann A.M....Casey P.J. (Proc. Natl. Acad. Sci. U.S.A. 2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23463	HGNC: 5350	AceView: ICMT	Ensembl:ENSG00000116237	euGenes: HUgn23463
ECgene: ICMT	Kegg: 23463	H-InvDB: ICMT

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ICMT	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ICMT gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ICMT gene:
Search GeneIP for patents involving ICMT

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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