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ICMT Gene

protein-coding   GIFtS: 64
GCID: GC01M006282

Isoprenylcysteine Carboxyl Methyltransferase

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Isoprenylcysteine Carboxyl Methyltransferase1 2     HSTE142
Protein-S-Isoprenylcysteine O-Methyltransferase1 2     MST0982
Prenylated Protein Carboxyl Methyltransferase2 3     MSTP0982
Prenylcysteine Carboxyl Methyltransferase2 3     PCMT2
PCCMT2 3     Protein-S Isoprenylcysteine O-Methyltransferase2
PPMT2 3     Isoprenylcysteine Carboxylmethyltransferase3
EC 2.1.1.1003 8     pcCMT3

External Ids:    HGNC: 53501   Entrez Gene: 234632   Ensembl: ENSG000001162377   OMIM: 6058515   UniProtKB: O607253   

Export aliases for ICMT gene to outside databases

Previous GC identifers: GC01M005857 GC01M006090 GC01M005990 GC01M006215 GC01M005429


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ICMT Gene:
This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine
residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the
endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity
of those transcripts has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for ICMT Gene:
ICMT (isoprenylcysteine carboxyl methyltransferase) is a protein-coding gene. Diseases associated with ICMT include legionnaires' disease, and hyperhomocysteinemia. GO annotations related to this gene include protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity and cAMP response element binding protein binding.

UniProtKB/Swiss-Prot: ICMT_HUMAN, O60725
Function: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues

Gene Wiki entry for ICMT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ICMT gene promoter:
         Max1   Bach2   NRSF form 1   NRSF form 2   COMP1   STAT3   ARP-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidICMT promoter sequence
   Search Chromatin IP Primers for ICMT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ICMT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.21   Ensembl cytogenetic band:  1p36.31   HGNC cytogenetic band: 1p36

ICMT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ICMT gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M006282:  view genomic region     (about GC identifiers)

Start:
6,281,253 bp from pter      End:
6,296,044 bp from pter
Size:
14,792 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ICMT_HUMAN, O60725 (See protein sequence)
Recommended Name: Protein-S-isoprenylcysteine O-methyltransferase  
Size: 284 amino acids; 31938 Da
Cofactor: Divalent cations. Probably zinc (By similarity)
Secondary accessions: Q6FHT0

Explore the universe of human proteins at neXtProt for ICMT: NX_O60725

Explore proteomics data for ICMT at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys278
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ICMT (O60725) (see all 6)
     RHPSYVG  SFLLNHS  SLIHFFGE  GTQVMLCNP 


    See ICMT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036537.1  
    ENSEMBL proteins: 
     ENSP00000343552   ENSP00000466222   ENSP00000467999   ENSP00000354894  

    ICMT Human Recombinant Protein Products:

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    Novus Biologicals ICMT Proteins
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for ICMT

    ICMT Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ICMT
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    Abcam antibodies for ICMT
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    LSBio Antibodies in human, mouse, rat for ICMT

    ICMT Assay Products:

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    Cloud-Clone Corp. ELISAs for ICMT
    Cloud-Clone Corp. CLIAs for ICMT


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR007269 ICMT_MeTrfase
     IPR025770 PPMT_MeTrfase

    Graphical View of Domain Structure for InterPro Entry O60725

    ProtoNet protein and cluster: O60725

    2 Blocks protein domains:
    IPB007269 Isoprenylcysteine carboxyl methyltransferase
    IPB011024 Gamma-crystallin related


    UniProtKB/Swiss-Prot: ICMT_HUMAN, O60725
    Similarity: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl
    methyltransferase family


    ICMT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ICMT_HUMAN, O60725
    Function: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues
    Catalytic activity: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine
    + protein C-terminal S-farnesyl-L-cysteine methyl ester

         Enzyme Number (IUBMB): EC 2.1.1.1001 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003880protein C-terminal carboxyl O-methyltransferase activity TAS9614111
    GO:0004671protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity IEA--
    GO:0008140cAMP response element binding protein binding IEA--
         
    ICMT for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ICMT:
     Synthetic lethal with Ras 

         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Icmt):
     cellular  embryogenesis  growth/size/body  hematopoietic system  integument 
     liver/biliary system  mortality/aging  nervous system  normal 

    ICMT for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ICMT: Icmttm1Hzo Icmttm1Sgy

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ICMT
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    miRNA
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    miRTarBase miRNAs that target ICMT:
    hsa-mir-1260b (MIRT052699), hsa-mir-331-3p (MIRT043333), hsa-mir-93-5p (MIRT028069), hsa-mir-124-3p (MIRT022702), hsa-mir-26b-5p (MIRT029560), hsa-mir-130b-3p (MIRT020175)

    Block miRNA regulation of human, mouse, rat ICMT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ICMT (see all 62):
    hsa-miR-4328 hsa-let-7d hsa-miR-106a hsa-miR-16-1* hsa-miR-3653 hsa-miR-519a hsa-let-7g hsa-miR-3142
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ICMT (NM_012405)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ICMT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICMT

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICMT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ICMT_HUMAN, O60725: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane2
    cytosol1
    extracellular1
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA9614111
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016020membrane TAS10441503
    GO:0016021integral component of membrane IEA--

    ICMT for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ICMT About    
    See pathways by source

    SuperPathContained pathways About
    1Immune response Antigen presentation by MHC class II
    G protein signaling N RAS regulation pathway0.46
    2superpathway of cholesterol biosynthesis
    Terpenoid backbone biosynthesis0.34
    3G protein signaling K RAS regulation pathway
    G protein signaling K RAS regulation pathway
    4G protein signaling H RAS regulation pathway
    G protein signaling H RAS regulation pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 GeneGo (Thomson Reuters) Pathways for ICMT
        G-protein signaling H-RAS regulation pathway
    G-protein signaling K-RAS regulation pathway
    G-protein signaling N-RAS regulation pathway


    1 Kegg Pathway  (Kegg details for ICMT):
        Terpenoid backbone biosynthesis


    ICMT for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ICMT
    Interactions:

        GeneGlobe Interaction Network for ICMT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for ICMT (O607253 ENSP000003435524) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAC2P151533, ENSP000002490714I2D: score=3 STRING: ENSP00000249071
    RHOAP615863, ENSP000004001754I2D: score=3 STRING: ENSP00000400175
    HRASP011123, ENSP000003098454I2D: score=2 STRING: ENSP00000309845
    USO1O607633, ENSP000004116984I2D: score=1 STRING: ENSP00000411698
    ZMPSTE24O758443, ENSP000003618454I2D: score=1 STRING: ENSP00000361845
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001889liver development IEA--
    GO:0006464cellular protein modification process TAS9614111
    GO:0006479protein methylation ----
    GO:0006481C-terminal protein methylation TAS10441503

    ICMT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ICMT

    2 HMDB Compounds for ICMT    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylhomocysteine(S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine (see all 19)979-92-0--
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--

    7 Novoseek inferred chemical compound relationships for ICMT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysmethynil 98.4 13 17209565 (2), 15784746 (2), 16757321 (1), 19157999 (1) (see all 6)
    s-adenosylhomocysteine 81.8 5 17360897 (2), 12631708 (1), 12750467 (1)
    s-adenosylmethionine 69.5 4 12631708 (1), 17360897 (1), 15625008 (1)
    homocysteine 51.5 3 12750467 (1), 17360897 (1)
    cysteine 35.8 4 16757321 (1), 15625008 (1)
    indole 32.9 3 17209565 (3)
    aspartate 4.56 2 11985579 (1), 10880963 (1)



    ICMT for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ICMT gene (2 alternative transcripts): 
    NM_012405.3  NM_170705.1  

    Unigene Cluster for ICMT:

    Isoprenylcysteine carboxyl methyltransferase
    Hs.515688  [show with all ESTs]
    Unigene Representative Sequence: NM_012405
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343813(uc001amk.3 uc001aml.3) ENST00000495791 ENST00000489498
    ENST00000474756 ENST00000362035

    miRNA
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    Block miRNA regulation of human, mouse, rat ICMT using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ICMT (see all 62):
    hsa-miR-4328 hsa-let-7d hsa-miR-106a hsa-miR-16-1* hsa-miR-3653 hsa-miR-519a hsa-let-7g hsa-miR-3142
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ICMT
      QuantiFast Probe-based Assays in human, mouse, rat ICMT

    Additional mRNA sequence: 

    AF173157.1 BC028168.1 CR541671.1 CR541711.1 

    16 DOTS entries:

    DT.100790533  DT.87017640  DT.100790540  DT.86855797  DT.95345873  DT.100790531  DT.95343582  DT.100790535 
    DT.121366499  DT.91771617  DT.40109201  DT.40109202  DT.86840009  DT.100029749  DT.91749368  DT.95283915 

    Selected AceView cDNA sequences (see all 374):

    BU617580 AW779430 AU141081 AW612700 BE220666 AI214943 AI222981 CN481591 
    CA314834 BM995289 BM676563 W79933 CN479517 BM454345 AA487020 BQ045104 
    BM772715 BU157494 CK904501 AI085228 BU689969 CA309880 AW169707 BM709703 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ICMT    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
    SP1:                                                                  
    SP2:                    -                                             
    SP3:                    -                                             
    SP4:                    -     -                                       


    ECgene alternative splicing isoforms for ICMT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ICMT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTTTGGAAG
    ICMT Expression
    About this image


    ICMT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Epithelial Cells
             Hepatoblasts Liver Bud
     
     Liver (Hepatobiliary System)
             Hepatoblasts Liver Bud
     
     Eye (Sensory Organs)
             Retina
     
     Peripheral Nervous System (Nervous System)
     
     Fibroblasts (Uncategorized)
    ICMT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ICMT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515688

    UniProtKB/Swiss-Prot: ICMT_HUMAN, O60725
    Tissue specificity: Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other
    brain regions. Abundant expression seen in the Purkinje cells and pontine neurons

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICMT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ICMT gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Icmt1 , 5 isoprenylcysteine carboxyl methyltransferase1, 5 89.08(n)1
    96.13(a)1
      4 (83.02 cM)5
    572951  NM_133788.21  NP_598549.11 
     1522972275 
    chicken
    (Gallus gallus)
    Aves ICMT1 isoprenylcysteine carboxyl methyltransferase 75.15(n)
    77.74(a)
      419373  NM_001006298.1  NP_001006298.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3977172 farnesyl cysteine carboxyl methyltransferase 73.58(n)    D87750.1 
    zebrafish
    (Danio rerio)
    Actinopterygii icmt1 isoprenylcysteine carboxyl methyltransferase 63.71(n)
    65.31(a)
      550281  NM_001017618.1  NP_001017618.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG112683
    ste141
    protein-S-isoprenylcysteine
    O-methyltransferase3
    isoprenylcysteine carboxylmethyltransferase1
    49(a)3
    54.74(n)1
    51.66(a)1
      69F53
    394781  NM_001274864.11  NP_001261793.11 
    worm
    (Caenorhabditis elegans)
    Secernentea M01E11.11 , 3 M01E11.11 43(a)
    (best of 2)3
    51.58(n)1
    46.27(a)1
      I(5582106-5583267)3
    1873741  NM_059234.41  NP_491635.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STE14(YDR410C)4
    STE141
    Farnesyl cysteine-carboxyl methyltransferase, mediates more4
    STE141
    50.94(n)1
    42.45(a)1
      4(1293091-1292372)4
    8520191, 4  NP_010698.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons STE14A1 STE14A 51.22(n)
    45.83(a)
      832396  NM_122238.1  NP_197723.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g06029001 Os04g0602900 52.89(n)
    47.33(a)
      4336894  NM_001060312.1  NP_001053777.1 


    ENSEMBL Gene Tree for ICMT (if available)
    TreeFam Gene Tree for ICMT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ICMT (see all 314)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1914838811,2
    --6281947(+) GACAGA/TACCTA 1 -- ut310--------
    rs1828572301,2
    --6281973(+) TCTCCA/CCTTTA 1 -- ut310--------
    rs1870796771,2
    --6282017(+) TTTTTC/TAAATC 1 -- ut310--------
    rs115385421,2
    C,H--6282155(+) AAAAAG/AAAGTC 1 -- ut31 ese32Minor allele frequency- A:0.01NS NA 172
    rs1115173831,2
    F--6282256(+) CGCGTG/AGATCA 1 -- ut311Minor allele frequency- A:0.50CSA 2
    rs1503913711,2
    --6282580(+) TCCCAC/TCATCC 1 -- ut310--------
    rs1834215781,2
    --6282626(+) CAAGTC/TTTCCC 1 -- ut310--------
    rs740495091,2
    C,F--6282679(+) TCCTGG/CGCTCC 1 -- ut312Minor allele frequency- C:0.19WA 120
    rs1877460281,2
    C--6282887(+) AAGAAC/GTTTTC 1 -- ut310--------
    rs1923026811,2
    --6282905(+) GAGCCA/GGGGCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ICMT (6281253 - 6296044 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ICMT (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508825CNV Insertion20534489
    nsv871698CNV Loss21882294
    dgv121n71CNV Loss21882294
    dgv120n71CNV Loss21882294
    dgv122n71CNV Loss21882294
    nsv870945CNV Loss21882294
    dgv123n71CNV Loss21882294
    nsv831425CNV Loss17160897
    nsv871385CNV Loss21882294
    nsv871569CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ICMT
    DNA2.0 Custom Variant and Variant Library Synthesis for ICMT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605851    OMIM disorders: --

    14 diseases for ICMT:    
    About MalaCards
    legionnaires' disease    hyperhomocysteinemia    uremia    spina bifida
    spinocerebellar ataxia    endometrial carcinoma    ataxia    liver disease
    neuroblastoma    endotheliitis    alzheimer's disease    melanoma
    malaria    neuronitis


    ICMT for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for ICMT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hyperhomocysteinemia 52.6 1 17360897 (1)
    necrosis 0 2 12631708 (1), 12006387 (1)
    tumors 0 2 12631708 (1), 12006387 (1)
    cancer 0 3 17964784 (1), 18466935 (1), 15784746 (1)

    Genetic Association Database (GAD): ICMT
    Human Genome Epidemiology (HuGE) Navigator: ICMT (2 documents)

    Export disorders for ICMT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ICMT gene, integrated from 10 sources (see all 69):
    (articles sorted by number of sources associating them with ICMT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. (PubMed id 9614111)1, 2, 3, 9 Dai Q.... Philips M.R. (J. Biol. Chem. 1998)
    2. Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe. (PubMed id 19158273)1, 2, 9 Wright L.P.... Philips M.R. (Mol. Cell. Biol. 2009)
    3. Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study. (PubMed id 19841875)1, 4 Fontaine-Bisson B....Morange P.E. (J. Mol. Med. 2010)
    4. An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). (PubMed id 19161160)1, 4 Franke B....Blom H.J. (Birth Defects Res. Part A Clin. Mol. Teratol. 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1. (PubMed id 10649571)1, 2 Lin X.... Zoghbi H.Y. (Nat. Neurosci. 2000)
    7. The carboxyl methyltransferase modifying G proteins is a metalloenzyme. (PubMed id 10441503)1, 3 Desrosiers R.R....BAcliveau R. (Biochem. Biophys. Res. Commun. 1999)
    8. Inhibition of ICMT induces endothelial cell apoptosis through GRP94. (PubMed id 17347446)1, 9 Lu Q....Rounds S. (Am. J. Respir. Cell Mol. Biol. 2007)
    9. Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis. (PubMed id 12631708)1, 9 Kramer K....Rounds S. (Mol. Biol. Cell 2003)
    10. Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate. (PubMed id 12750467)1, 9 Winter-Vann A.M....Casey P.J. (Proc. Natl. Acad. Sci. U.S.A. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23463 HGNC: 5350 AceView: ICMT Ensembl:ENSG00000116237 euGenes: HUgn23463
    ECgene: ICMT Kegg: 23463 H-InvDB: ICMT

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ICMT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ICMT gene:
    Search GeneIP for patents involving ICMT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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