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Aliases for ICMT Gene

Aliases for ICMT Gene

  • Isoprenylcysteine Carboxyl Methyltransferase 2 3 5
  • Prenylated Protein Carboxyl Methyltransferase 3 4
  • Prenylcysteine Carboxyl Methyltransferase 3 4
  • EC 4 63
  • PCCMT 3 4
  • PPMT 3 4
  • Protein-S-Isoprenylcysteine O-Methyltransferase 2
  • Protein-S Isoprenylcysteine O-Methyltransferase 3
  • Isoprenylcysteine Carboxylmethyltransferase 4
  • MSTP098 3
  • HSTE14 3
  • MST098 3
  • PCMT 3

External Ids for ICMT Gene

Previous GeneCards Identifiers for ICMT Gene

  • GC01M005857
  • GC01M006090
  • GC01M005990
  • GC01M006215
  • GC01M005429

Summaries for ICMT Gene

Entrez Gene Summary for ICMT Gene

  • This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ICMT Gene

ICMT (Isoprenylcysteine Carboxyl Methyltransferase) is a Protein Coding gene. Diseases associated with ICMT include Legionaire Disease. Among its related pathways are Gamma carboxylation, hypusine formation and arylsulfatase activation and G-protein signaling_H-RAS regulation pathway. GO annotations related to this gene include cAMP response element binding protein binding and protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity.

UniProtKB/Swiss-Prot for ICMT Gene

  • Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.

Gene Wiki entry for ICMT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICMT Gene

Genomics for ICMT Gene

Regulatory Elements for ICMT Gene

Enhancers for ICMT Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ICMT on UCSC Golden Path with GeneCards custom track

Promoters for ICMT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ICMT on UCSC Golden Path with GeneCards custom track

Genomic Location for ICMT Gene

6,221,193 bp from pter
6,235,984 bp from pter
14,792 bases
Minus strand

Genomic View for ICMT Gene

Genes around ICMT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICMT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICMT Gene

Proteins for ICMT Gene

  • Protein details for ICMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein-S-isoprenylcysteine O-methyltransferase
    Protein Accession:
    Secondary Accessions:
    • Q6FHT0

    Protein attributes for ICMT Gene

    284 amino acids
    Molecular mass:
    31938 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for ICMT Gene

Proteomics data for ICMT Gene at MOPED

Selected DME Specific Peptides for ICMT Gene

Post-translational modifications for ICMT Gene

  • Ubiquitination at Lys 278
  • Modification sites at PhosphoSitePlus

Other Protein References for ICMT Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CMT

Domains & Families for ICMT Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
  • Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
genes like me logo Genes that share domains with ICMT: view

No data available for Gene Families for ICMT Gene

Function for ICMT Gene

Molecular function for ICMT Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.
UniProtKB/Swiss-Prot Function:
Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.

Enzyme Numbers (IUBMB) for ICMT Gene

genes like me logo Genes that share phenotypes with ICMT: view

Animal Models for ICMT Gene

MGI Knock Outs for ICMT:

Animal Model Products

  • Taconic Biosciences Mouse Models for ICMT

miRNA for ICMT Gene

miRTarBase miRNAs that target ICMT

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ICMT Gene

Localization for ICMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICMT Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ICMT Gene COMPARTMENTS Subcellular localization image for ICMT gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
cytosol 1
extracellular 1
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ICMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA,TAS --
genes like me logo Genes that share ontologies with ICMT: view

Pathways & Interactions for ICMT Gene

genes like me logo Genes that share pathways with ICMT: view

Gene Ontology (GO) - Biological Process for ICMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 9614111
GO:0046498 S-adenosylhomocysteine metabolic process IEA --
genes like me logo Genes that share ontologies with ICMT: view

No data available for SIGNOR curated interactions for ICMT Gene

Drugs & Compounds for ICMT Gene

(4) Drugs for ICMT Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0

(3) Additional Compounds for ICMT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ICMT: view

Transcripts for ICMT Gene

Unigene Clusters for ICMT Gene

Isoprenylcysteine carboxyl methyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ICMT Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP2: -
SP3: -
SP4: - -

Relevant External Links for ICMT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ICMT Gene

mRNA expression in normal human tissues for ICMT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ICMT Gene

This gene is overexpressed in Lung (25.4) and Placenta (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ICMT Gene

SOURCE GeneReport for Unigene cluster for ICMT Gene Hs.515688

mRNA Expression by UniProt/SwissProt for ICMT Gene

Tissue specificity: Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.
genes like me logo Genes that share expression patterns with ICMT: view

Protein tissue co-expression partners for ICMT Gene

Primer Products

No data available for mRNA differential expression in normal tissues for ICMT Gene

Orthologs for ICMT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ICMT Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ICMT 35
  • 92.61 (n)
  • 97.18 (a)
(Mus musculus)
Mammalia Icmt 35
  • 89.08 (n)
  • 96.13 (a)
Icmt 16
Icmt 36
  • 96 (a)
(Pan troglodytes)
Mammalia ICMT 35
  • 99.53 (n)
  • 99.65 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Icmt 35
  • 88.03 (n)
  • 95.07 (a)
(Bos Taurus)
Mammalia ICMT 36
  • 88 (a)
(Monodelphis domestica)
Mammalia ICMT 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia ICMT 36
  • 88 (a)
(Gallus gallus)
Aves ICMT 35
  • 75.15 (n)
  • 77.74 (a)
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia icmt 35
  • 70.48 (n)
  • 73.43 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC397717 35
(Danio rerio)
Actinopterygii icmt 35
  • 63.71 (n)
  • 65.31 (a)
icmt 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11268 37
  • 49 (a)
ste14 35
  • 54.74 (n)
  • 51.66 (a)
ste14 36
  • 46 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001310 35
  • 52.52 (n)
  • 50.18 (a)
(Caenorhabditis elegans)
Secernentea F21F3.3 37
  • 42 (a)
M01E11.1 37
  • 43 (a)
M01E11.1 35
  • 51.58 (n)
  • 46.27 (a)
F21F3.3 36
  • 33 (a)
M01E11.1 36
  • 35 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR122C 35
  • 50.55 (n)
  • 37.91 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A02167g 35
  • 50.08 (n)
  • 41.31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STE14 35
  • 50.94 (n)
  • 42.45 (a)
STE14 36
  • 38 (a)
STE14 38
thale cress
(Arabidopsis thaliana)
eudicotyledons STE14A 35
  • 51.22 (n)
  • 45.83 (a)
(Oryza sativa)
Liliopsida Os04g0602900 35
  • 52.89 (n)
  • 47.33 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00034 35
  • 48.97 (n)
  • 42.18 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mam4 35
  • 45.95 (n)
  • 41.26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10934 36
  • 39 (a)
Species with no ortholog for ICMT:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ICMT Gene

Gene Tree for ICMT (if available)
Gene Tree for ICMT (if available)

Paralogs for ICMT Gene

No data available for Paralogs for ICMT Gene

Variants for ICMT Gene

Sequence variations from dbSNP and Humsavar for ICMT Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2732 -- 6,223,538(+) TGAAC(A/G)TACAT utr-variant-3-prime
rs846106 -- 6,234,012(-) AATGA(A/G)CTGGG intron-variant
rs846107 -- 6,233,935(-) ggagg(C/T)ggagg intron-variant
rs846108 -- 6,233,332(+) TTTAT(A/C/G/T)AAGGA intron-variant
rs846109 -- 6,229,775(-) TTTTT(A/T)ATTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ICMT Gene

Variant ID Type Subtype PubMed ID
nsv871698 CNV Loss 21882294
nsv870945 CNV Loss 21882294
dgv119n71 CNV Loss 21882294
nsv831425 CNV Loss 17160897
dgv120n71 CNV Loss 21882294
dgv121n71 CNV Loss 21882294
dgv8n67 CNV Gain 20364138
nsv508825 CNV Insertion 20534489
nsv871569 CNV Loss 21882294
dgv122n71 CNV Loss 21882294
dgv123n71 CNV Loss 21882294
nsv871385 CNV Loss 21882294

Variation tolerance for ICMT Gene

Residual Variation Intolerance Score: 56.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.92; 35.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ICMT Gene

Disorders for ICMT Gene

MalaCards: The human disease database

(1) MalaCards diseases for ICMT Gene - From: DISEASES

Disorder Aliases PubMed IDs
legionaire disease
  • legionnaires' disease
- elite association - COSMIC cancer census association via MalaCards
Search ICMT in MalaCards View complete list of genes associated with diseases

Relevant External Links for ICMT

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ICMT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ICMT Gene

Publications for ICMT Gene

  1. Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. (PMID: 9614111) Dai Q. … Philips M.R. (J. Biol. Chem. 1998) 2 3 4 23 67
  2. Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe. (PMID: 19158273) Wright L.P. … Philips M.R. (Mol. Cell. Biol. 2009) 3 23
  3. Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration. (PMID: 19651782) Cushman I. … Casey P.J. (J. Biol. Chem. 2009) 3 23
  4. Inhibition of ICMT induces endothelial cell apoptosis through GRP94. (PMID: 17347446) Lu Q. … Rounds S. (Am. J. Respir. Cell Mol. Biol. 2007) 3 23
  5. Isoprenylcysteine carboxyl methyltransferase activity modulates endothelial cell apoptosis. (PMID: 12631708) Kramer K. … Rounds S. (Mol. Biol. Cell 2003) 3 23

Products for ICMT Gene

Sources for ICMT Gene