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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ICK Gene

protein-coding GIFtS: 57
GCID: GC06M052912

intestinal cell (MAK-like) kinase

Explore 8 diseases affiliated with
ICK via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Intestinal Cell (MAK-Like) Kinase¹ ²		EC 2.7.11.22³ ⁸
MRK¹ ² ³ ⁵		ECO² ⁵
LCK2¹ ² ³		MGC46090¹
KIAA0936¹ ³ ⁵		Serine/Threonine Protein Kinase²
Laryngeal Cancer Kinase 2² ³		Serine/Threonine-Protein Kinase ICK²
HICK¹		Intestinal Cell Kinase³
MAK-Related Kinase² ³		EC 2.7.11⁸

External Ids:	HGNC: 21219¹	Entrez Gene: 22858²	Ensembl: ENSG00000112144⁷	OMIM: 612325⁵	UniProtKB: Q9UPZ9³

Export aliases for ICK gene to outside databases

Previous GC identifers: GC06M052868 GC06M052974 GC06M052698

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ICK:

Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved

catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal

serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The

protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell

proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the

same isoform, have been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ICK_HUMAN, Q9UPZ9

Function: May play a key role in the development of multiple organ systems and particularly in cardiac development (By

similarity)

Gene Wiki entry for ICK

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ICK gene promoter:
Brachyury GCNF STAT5A Ik-3 RORalpha2 SRY HFH-1 GCNF-1 GCNF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ICK promoter sequence

Search SABiosciences Chromatin IP Primers for ICK

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ICK

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.1 Ensembl cytogenetic band: 6p12.1 HGNC cytogenetic band: 6p12.3-p11.2

ICK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ICK gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M052912: view genomic region (about GC identifiers)

Start:	52,866,077 bp from pter	End:	52,926,600 bp from pter
Size:	60,524 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ICK_HUMAN, Q9UPZ9 (See protein sequence)

Recommended Name: Serine/threonine-protein kinase ICK

Size: 632 amino acids; 71427 Da

Cofactor: Magnesium

Subcellular location: Nucleus. Cytoplasm, cytosol (By similarity). Note=Nuclear localization has been observed with a

GFP-tagged construct in transfected HeLa cells (PubMed:12103360). Cytosolic localization was shown in rat embryonic

cardiomyocytes by immunostaining (PubMed:8570168)

Sequence caution: Sequence=BAA76780.2; Type=Erroneous initiation;

Secondary accessions: A7MD41 O75985 Q5THL2 Q8IYH8 Q9BX17 Q9NYX3

Alternative splicing: 2 isoforms: Q9UPZ9-1 Q9UPZ9-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ICK: NX_Q9UPZ9

Post-translational modifications:

Autophosphorylated on serine and threonine residues. May play a role in enzyme activation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UPZ9

4/6 DME Specific Peptides for ICK (Q9UPZ9) (see all 6)

LKPENLL

VHGRTDW

RDLKPEN

PKKRPTA

ICK Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_055735.1 NP_057597.2

ENSEMBL proteins:

ENSP00000263043 ENSP00000349458

Human Recombinant Protein Products for ICK:

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	Novus Biologicals ICK Proteins Novus Biologicals ICK Lysates
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	Uscn Proteins for ICK

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	IEA	--
GO:0043231	intracellular membrane-bounded organelle	IDA	--

ICK for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ICK

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ICK for domains About GeneDecksing

5 InterPro domains/families:

IPR017441 Protein_kinase_ATP_BS

IPR002290 Ser/Thr_dual-sp_kinase_dom

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_kinase_AS

IPR000719 Prot_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry Q9UPZ9

ProtoNet protein and cluster: Q9UPZ9

UniProtKB/Swiss-Prot: ICK_HUMAN, Q9UPZ9

Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ICK_HUMAN, Q9UPZ9

Function: May play a key role in the development of multiple organ systems and particularly in cardiac development (By

similarity)

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB): EC 2.7.11.22¹ ² EC 2.7.11²

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IDA	10699974
GO:0004674	protein serine/threonine kinase activity	IDA	10699974
GO:0004693	cyclin-dependent protein kinase activity	IEA	--
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IDA	10699974

ICK for ontologies About GeneDecksing

Phenotypes:
4 GenomeRNAi human phenotypes for ICK:

Decreased substrate adherent c

Increased cell death HMECs cel

Synthetic lethal with Ras

Wnt reporter downregulated

1 MGI phenotypic allele

for Ick (no phenotypes)

ICK for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ICK

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ICK Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ICK
		8/82 QIAGEN miScript miRNA Assays for microRNAs that regulate ICK (see all 82):
		hsa-miR-3130-5p hsa-miR-3607-3p hsa-miR-607 hsa-miR-300 hsa-miR-485-3p hsa-miR-374a hsa-miR-30d hsa-miR-3653

		SwitchGear 3'UTR luciferase reporter plasmid: ICK 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICK

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ICK

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

5/40 Interacting proteins for ICK (Q9UPZ9^{1, 2, 3} ENSP00000263043⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 40)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMAD1	Q15797²^,³	MINT-62019 I2D: score=3
ATP6V0D1	P61421³	I2D: score=5
CCT2	P78371³	I2D: score=4
TCP1	P17987³	I2D: score=4
FZR1	Q9UM11³	I2D: score=3

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein phosphorylation	IDA	10699974
GO:0007165	signal transduction	TAS	10699974
GO:0007243	intracellular protein kinase cascade	IDA	10699974
GO:0007275	multicellular organismal development	IEA	--

ICK for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ICK

3 HMDB Compounds for ICK About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Magnesium	Magnesium (see all 2)	7439-95-4	--

Search CenterWatch for drugs/clinical trials and news about ICK

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ICK gene (2 alternative transcripts):

NM_014920.3 NM_016513.4

Unigene Cluster for ICK:

Intestinal cell (MAK-like) kinase

Hs.417022 [show with all ESTs]

Unigene Representative Sequence: NM_016513

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000350082 ENST00000356971(uc003pbh.2 uc003pbi.2 uc003pbj.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ICK Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ICK
		8/82 QIAGEN miScript miRNA Assays for microRNAs that regulate ICK (see all 82):
		hsa-miR-3130-5p hsa-miR-3607-3p hsa-miR-607 hsa-miR-300 hsa-miR-485-3p hsa-miR-374a hsa-miR-30d hsa-miR-3653

		SwitchGear 3'UTR luciferase reporter plasmid: ICK 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ICK

Additional cDNA sequence:

AB023153.1 AF152469.1 AF225919.1 AJ420557.1 AK074892.1 BC035807.1 BC136420.1 BC136421.1

BC152464.1 BX647493.1

8 DOTS entries:

DT.95372370 DT.115329 DT.100663013 DT.100018316 DT.40195675 DT.100805092 DT.92426700 DT.92426701

24/127 AceView cDNA sequences (see all 127):

AA736840 AA889876 AA733178 NM_014920 BM932175 AI796746 CB128950 BM852751

AL600198 Z38609 AI218356 BM548744 BF514365 CA312371 AI560203 NM_016513

BX505790 AA766751 AB023153 AW872989 BQ440526 AA428139 AW241393 AL530318

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ICK (see all 6) About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16a	·	16b	·	16c	·	16d
SP1:			-						-														-								-				-
SP2:			-		-				-														-								-				-
SP3:									-
SP4:																																			-
SP5:			-		-

ECgene alternative splicing isoforms for ICK

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ICK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See ICK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ICK

SOURCE GeneReport for Unigene cluster: Hs.417022

UniProtKB/Swiss-Prot: ICK_HUMAN, Q9UPZ9

Tissue specificity: Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and

colon, with highest levels in placenta and testis. Not detected in spleen. Also expressed in many cancer cell lines

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ICK gene from 6/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ICK¹	intestinal cell (MAK-like) kinase	75.2(n) 76.17(a)		421896 XM_419912.3 XP_419912.3
lizard (Anolis carolinensis)	Reptilia	ICK⁶	--	71(a)	1 ↔ 1	1(151669078-151688443)
fruit fly (Drosophila melanogaster)	Insecta	CG42366⁶	--	32(a)	1 → many	2L(9925161-9930378)
worm (Caenorhabditis elegans)	Secernentea	M04C9.5³	serine/threonine kinase (CDC2/CDKX subfamily)	67(a) (best of 2)		I(9367904-9370983) --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G19110⁶ MHK⁶ (see all 3)	serine/threonine-protein kinase MHK (see all 3)	38(a) 38(a) (see all 3)	many ↔ many many ↔ many (see all 3)	4(10454497-10459328) 4(7603101-7607155)
rice (Oryza sativa)	Liliopsida	Os02g0700600¹	hypothetical protein	54.66(n) 51.4(a)		4330434 NM_001054376.1 NP_001047841.1

ENSEMBL Gene Tree for ICK (if available)
TreeFam Gene Tree for ICK (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ICK gene

CDKL1² CDKL2² CDKL5² MOK² CDKL3² MAK² CDKL4²

18 SIMAP similar genes for ICK using alignment to 1 protein entry: ICK_HUMAN:

MAK CDK2 CDK3 CDK10 CDK7 MOK

CDK16 PCTK1 CDK4 CDK6 MAPK1 MAPK14

PRKAA1 MAPK12 CDK9 MAPK11 MAPK13 GSK3B

ICK for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192638784^1,2		--	52865601(+)	`ACAGGG/TCCTCA`	2	--	ds500¹		0	--	--	--	--
rs138973140^1,2		--	52865675(+)	`GCTCAA/GGTGAT`	2	--	ds500¹		0	--	--	--	--
rs184222803^1,2		--	52865820(+)	`CCTCAC/TGCCTC`	2	--	ds500¹		0	--	--	--	--
rs9382167^1,2	A	--	52865835(+)	`tcccaA/Gagtgc`	2	--	ds500¹		0	--	--	--	--
rs187948984^1,2		--	52865840(+)	`GAGTGA/CCGGGA`	2	--	ds500¹		0	--	--	--	--
rs2397135^1,2	C,F,A,H	--	52865902(+)	`TTTAAC/AAAAAC`	2	--	ds500¹		13		NS EA NA WA	922
rs2397136^1,2	C,F,A,H	--	52865914(+)	`TCCACA/GTTGCA`	2	--	ds500¹		19		NS EA NA WA CSA	2344
rs200796689^1,2		--	52866144(+)	`TTTCC-/TTACA TAAGG`	2	--	ut3¹		0	--	--	--	--
rs10950^1,2	C,F	--	52866287(+)	`ATTGTC/TGGTTA`	2	--	ut3¹ ese³		2		MN WA	302
rs75183762^1,2	C,F	--	52866331(+)	`ATCTGT/CACTGA`	2	--	ut3¹		1		EA	120

HapMap Linkage Disequilibrium report for ICK (52866077 - 52926600 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ICK: --
Human Gene Mutation Database (HGMD): ICK

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ICK

DNA2.0 Custom Variant and Variant Library Synthesis for ICK

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ICK for disorders           About GeneDecksing

OMIM gene information: 612325
OMIM disorders: 612651
UniProtKB/Swiss-Prot: ICK_HUMAN, Q9UPZ9

Defects in ICK are the cause of endocrine-cerebroosteodysplasia (ECO) [MIM:612651]. ECO is a previously

unidentified neonatal lethal recessive disorder with multiple anomalies involving the endocrine, cerebral, and

skeletal systems

8 diseases for ICK: About MalaCards

laryngeal cancer endocrine-cerebroosteodysplasia laryngitis ehrlichiosis

keratopathy malaria prostatitis neuronitis

1 disease from the University of Copenhagen DISEASES database for ICK:

Ehrlichiosis

Human Genome Epidemiology (HuGE) Navigator: ICK (1 document)

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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ICK gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with ICK)

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The identification and subcellular localization of human MRK. (PubMed id 12103360)^{1, 2, 3} Yang T.... Chen J. (2002)
Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases. (PubMed id 10699974)^{1, 2, 9} Togawa K.... Rustgi A.K. (2000)
A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems. (PubMed id 19185282)^{1, 2, 9} Lahiry P.... Hegele R.A. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)^{1, 2} Nagase T.... Ohara O. (1999)
Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase. (PubMed id 16954377)^{1, 9} Fu Z....Sturgill T.W. (2006)
The promoter for intestinal cell kinase is head-to-he ad with F-Box 9 and contains functional sites for TCF7L2 and FOXA factors. (PubMed id 20459822)^{1, 9} Sturgill T.W....Mayo M.W. (2010)
Intestinal cell kinase (ICK) promotes activation of mT OR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908. (PubMed id 22356909)¹ Wu D....Fu Z. (2012)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 22858	HGNC: 21219	AceView: ICK	Ensembl:ENSG00000112144	euGenes: HUgn22858
ECgene: ICK	H-InvDB: ICK

(According to HUGE)
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HUGE: KIAA0936

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ICK	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ICK gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ICK gene:
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