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ICK Gene

protein-coding GIFtS: 59

GC06M052974

intestinal cell (MAK-like) kinase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.11.22 ^³
ECO ^², ⁵
KIAA0936 ^¹, ², ³, ⁵
LCK2 ^¹, ², ³
MGC46090 ^¹, ²
MRK ^¹, ², ³, ⁵
OTTHUMP00000016630 ^²
OTTHUMP00000039961 ^²
hICK ^³

Descriptions
Intestinal cell kinase ^², ³
Laryngeal cancer kinase 2 ^³
MAK-related kinase ^², ³
intestinal cell (MAK-like) kinase ^²
serine/threonine protein kinase ^²

External Ids
HGNC: 21219¹
Entrez Gene: 22858²
UniProtKB: Q9UPZ9³
Ensembl: ENSG00000112144⁷

Search outside databases for aliases for ICK gene

Previous GC identifers: GC06M052868 GC06M052912

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ICK:

Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which

share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases.

This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site

found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt

region and is thought to be important in intestinal epithelial cell proliferation and

differentiation. Alternative splicing has been observed at this locus and two variants, encoding

the same isoform, have been identified. [provided by RefSeq]

UniProtKB/Swiss-Prot: ICK_HUMAN, Q9UPZ9

Function: May play a key role in the development of multiple organ systems and particularly in

cardiac development (By similarity)

Gene Wiki entry for ICK

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ICK gene

Entrez Gene cytogenetic band: 6p12.1 Ensembl cytogenetic band: 6p12.1 HGNC cytogenetic band: 6p12.3-p11.2

ICK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M052974: (about GC identifiers)

Start:	52,974,057 bp from pter
End:	53,034,559 bp from pter
Size:	60,503 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000006.10 NT_007592.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ICK_HUMAN, Q9UPZ9 (See protein sequence)

Recommended Name: Serine/threonine-protein kinase ICK

Size: 632 amino acids; 71427 Da

Cofactor: Magnesium

Subcellular location: Nucleus. Cytoplasm, cytosol (By similarity). Note=Nuclear localization has

been observed with a GFP-tagged construct in transfected HeLa cells (PubMed:12103360). Cytosolic

localization was shown in rat embryonic cardiomyocytes by immunostaining (PubMed:8570168)

Secondary accessions: O75985 Q5THL2 Q8IYH8 Q9BX17 Q9NYX3

Alternative splicing: 2 isoforms: Q9UPZ9-1 Q9UPZ9-2

Post-translational modifications:

Autophosphorylated on serine and threonine residues. May play a role in enzyme activation¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_055735.1 NP_057597.2

ENSEMBL proteins:

ENSP00000263043 ENSP00000349458

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (ICK)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

About this table

Antibodies for ICK:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ICK
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Monoclonal and Polyclonal Antibodies from Abnova (ICK)
	Novus Biologicals Antibody for ICK

Assays for ICK:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9UPZ9

ProtoNet protein and cluster: Q9UPZ9

UniProtKB/Swiss-Prot: ICK_HUMAN, Q9UPZ9

Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.

CDC2/CDKX subfamily

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ICK)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ICK)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_173041

Applied Biosystems Silencer® siRNAs for ICK

Sigma-Aldrich siRNA and siRNA Panels for ICK

Sigma-Aldrich shRNA Panels and shRNA for ICK

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ICK
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_014920
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_014920
untagged cDNA clones in CMV expression vector (see all 4): BC035807

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_016513

UniProtKB/Swiss-Prot: ICK_HUMAN, Q9UPZ9

Function: May play a key role in the development of multiple organ systems and particularly in

cardiac development (By similarity)

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Number (IUBMB): EC 2.7.11.22

1 MGI phenotypic allele for Ick (no phenotypes)

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0000287	magnesium ion binding	IDA	10699974
GO:0004693	cyclin-dependent protein kinase activity	IEA	--
GO:0005524	ATP binding	IDA	10699974
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Interacting protein for ICK (Q9UPZ9²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
SMAD1 Q15797² MINT-62019
About this table
4 Gene Ontology (GO) biological process terms (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein amino acid phosphorylation IDA 10699974
GO:0007165 signal transduction TAS 10699974
GO:0007243 protein kinase cascade IDA 10699974
GO:0007275 multicellular organismal development IEA --
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ICK

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ICK)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ICK)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_173041

Sigma-Aldrich siRNA and siRNA Panels for ICK

Sigma-Aldrich shRNA Panels and shRNA for ICK

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_014920 NM_016513

REFSEQ mRNAs for ICK gene (2 alternative transcripts):

NM_014920.3 NM_016513.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_014920 NM_016513

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_014920
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_014920
                                 untagged cDNA clones in CMV expression vector (see all 4): BC035807

Additional cDNA sequence:

AB023153.1 AF152469.1 AF225919.1 AJ420557.1 AK074892.1 BC035807.1 BC136420.1 BC136421.1

BC152464.1 BX647493.1 CR608568.1

8 DOTS entries:

DT.95372370 DT.115329 DT.100663013 DT.100018316 DT.40195675 DT.100805092 DT.92426700 DT.92426701

24/127 AceView cDNA sequences (see all 127 ):

Z42402 BU186351 AK074892 AA766751 BG681441 AA428138 AA733178 CD245100

AW872989 AA993852 AL600198 CR608568 AB023153 NM_016513 AA908456 AI468694

BF514365 AA736840 AA452290 AI796746 BQ022166 BM128705 Z38609 AA428139

highest scoring ESTs for ICK:

AB023153 AA908197 AF152469 AK074892 BX490894 AA045951 AA047491 AA428139 AA452290 AA628396

Unigene Cluster for ICK:

Intestinal cell (MAK-like) kinase

Hs.417022 [show with all ESTs]

Unigene Representative Sequence: NM_016513

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ICK (see all 6 )

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16a	·	16b	·	16c	·	16d
SP1:			-						-														-								-				-
SP2:			-		-				-														-								-				-
SP3:									-
SP4:																																			-
SP5:			-		-

About this scheme

ECgene alternative splicing isoforms for ICK

2 Ensembl transcripts including schematic representations:

ENST00000350082 ENST00000356971

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ICK expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ICK

¹ / ² / ³

4 probe-sets matching ICK gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
41431_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AB023153	1.00	1.00	1.00	1
204569_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_014920	0.60	1.00	0.82	1
204569_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1552837_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.417022
Expression variation in blood from EXPOLDB for ICK
UniProtKB/Swiss-Prot: ICK_HUMAN, Q9UPZ9
Tissue specificity: Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary,
small intestine and colon, with highest levels in placenta and testis. Not detected in spleen.
Also expressed in many cancer cell lines

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ICK gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ICK¹	--	intestinal cell (MAK-like) kinase	90.45(n) 93.35(a)	481843 XM_538964.2 XP_538964.2
chimpanzee (Pan troglodytes)	ICK¹	--	intestinal cell (MAK-like) kinase	99.47(n) 99.21(a)	462772 XM_001154965.1 XP_001154965.1
cow (Bos taurus)	ICK¹	--	intestinal cell (MAK-like) kinase	88.43(n) 92.04(a)	506286 XM_582713.3 XP_582713.3
rat (Rattus norvegicus)	Ick¹	--	intestinal cell kinase	84.63(n) 86.01(a)	84411 NM_138886.1 NP_620241.1
mouse (Mus musculus)	Ick^{1, 5}	9⁵	intestinal cell kinase^{1, 5}	84.63(n)¹ 86.49(a)¹	56542¹ NM_019987.1¹ NP_064371.1¹ AF225918⁵ AI848300⁵ (see all 19)

About this table Species with no ortholog for ICK

ENSEMBL Gene Tree for ICK

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ICK gene

MAK²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/231 NCBI SNPs in ICK are shown (see all 231 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 98)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2397135^1,2	A,C,F,H	52973861(+)	`TTTAAC/AAAAAC`	2	--	ng5¹		7		EU EA WA NA	558
	rs2397136^1,2	A,C,F,H	52973873(+)	`TCCACA/GTTGCA`	2	--	ng5¹		4		EU EA WA	420
	rs1493105^1,2	C,H	53003887(-)	`GTTTCC/TTGAGT`	2	P/L	mis¹ ese³		4		EU EA WA	406
	rs33936662^1,2	C,F	52986613(+)	`TGGGAC/TTGGCT`	2	V/I	mis¹		5		NA EU EA WA	494
	rs3756976^1,2	F,H	53035357(-)	`gctaaT/Agttta`	2	--	ng3¹		3		EA WA	298
--	rs9382167^1,2	A	52973794(+)	`tcccaA/Gagtgc`	2	--	ng5¹		0	--	--	--	--
--	rs17616213^1,2	F	53034910(+)	`TTTTCT/GGATTT`	2	--	ng3¹		3		NA	142
	rs967762^1,2	C	53035274(-)	`CTCTAG/TCCTTA`	2	--	ng3¹ tfbs³		0	--	--	--	--
	rs1565699^1,2	H	52977880(+)	`CTAGGA/CAGAGA`	2	--	ut3¹ ese³		9		NA EA MN EU WA	666
	rs2297211^1,2	A,C,F,H	52986596(+)	`GCTGGT/CGGCTG`	2	P/P	syn¹ ese³		3		EA NA	248

About this table

HapMap Linkage Disequilibrium images for ICK (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 612325 disorders: 612651

UniProtKB/Swiss-Prot: ICK_HUMAN, Q9UPZ9

Defects in ICK are the cause of endocrine-cerebroosteodysplasia (ECO) [MIM:612651]. ECO is

a previously unidentified neonatal lethal recessive disorder with multiple anomalies involving the

endocrine, cerebral, and skeletal systems

Human Gene Mutation Database: ICK
Human Genome Epidemiology Navigator: ICK (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/16 PubMed articles for ICK gene (see all 16 ):

The identification and subcellular localization of human MRK. (PubMed id 12103360)^{2, 3, 4} Yang T....Chen J. (2002)
Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases. (PubMed id 10699974)^{1, 3, 4} Togawa K.... Rustgi A.K. (2000)
A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems. (PubMed id 19185282)^{1, 3, 4} Lahiry P....Hegele R.A. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{3, 4} Mungall A.J.... Beck S. (2003)
Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)^{3, 4} Nagase T....Ohara O. (1999)
Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)³ Trynka G....Wijmenga C. (2009)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)³ Barbe L....Andersson-Svahn H. (2008)
Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)⁴ Greenman C.... Stratton M.R. (2007)
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. (PubMed id 18083107)⁴ Rikova K....Comb M.J. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 22858	HGNC: 21219	AceView: ICK	Ensembl:ENSG00000112144	euGenes: HUgn22858
ECgene: ICK	H-InvDB: ICK

(According to HUGE)
About This Section

HUGE: KIAA0936

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for ICK
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ICK:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ICK-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ICK		Antibodies for ICK
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ICK		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ICK)
	Antibodies (ICK)
	Chimera RNAi (ICK)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

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Search OriGene for ICK

Search Tocris compounds for ICK

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ICK

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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ICK Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for ICK

Summaries
for ICK

Genomic Location
for ICK

Proteins
for ICK

Protein Domains/
Families
for ICK

Gene Function
for ICK

Pathways & Interactions
for ICK

Drugs & Compounds
for ICK

Transcripts
for ICK

Expression
for ICK

Orthologs
for ICK

Paralogs
for ICK

SNPs/Variants
for ICK

Disorders & Mutations
for ICK

Medical News
for ICK

Publications
for ICK

Search for ICK

Genome Databases showing ICK

Other Databases showing ICK

Specialized Databases showing ICK

Licensable Technologies
for ICK

Services
for ICK

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ICK Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor ICK

Summariesfor ICK

Genomic Locationfor ICK

Proteinsfor ICK

Protein Domains/Familiesfor ICK

Gene Functionfor ICK

Pathways & Interactionsfor ICK

Drugs & Compoundsfor ICK

Transcriptsfor ICK

Expression for ICK

Orthologsfor ICK

Paralogsfor ICK

SNPs/Variantsfor ICK

Disorders & Mutationsfor ICK

Medical Newsfor ICK

Publicationsfor ICK

Search for ICK

Genome Databases showing ICK

Other Databases showing ICK

Specialized Databases showing ICK

Licensable Technologiesfor ICK

Servicesfor ICK

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ICK

Summaries
for ICK

Genomic Location
for ICK

Proteins
for ICK

Protein Domains/
Families
for ICK

Gene Function
for ICK

Pathways & Interactions
for ICK

Drugs & Compounds
for ICK

Transcripts
for ICK

Expression
for ICK

Orthologs
for ICK

Paralogs
for ICK

SNPs/Variants
for ICK

Disorders & Mutations
for ICK

Medical News
for ICK

Publications
for ICK

Licensable Technologies
for ICK

Services
for ICK