Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ICK Gene

Aliases for ICK Gene

  • Intestinal Cell (MAK-Like) Kinase 2 3
  • MRK 3 4 6
  • Laryngeal Cancer Kinase 2 3 4
  • MAK-Related Kinase 3 4
  • EC 4 63
  • KIAA0936 4 6
  • LCK2 3 4
  • HICK 3 4
  • ECO 3 6
  • Serine/Threonine-Protein Kinase ICK 3
  • Serine/Threonine Protein Kinase 3
  • Intestinal Cell Kinase 4
  • EC 2.7.11 63

External Ids for ICK Gene

Previous GeneCards Identifiers for ICK Gene

  • GC06M052868
  • GC06M052912
  • GC06M052974
  • GC06M052698

Summaries for ICK Gene

Entrez Gene Summary for ICK Gene

  • Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for ICK Gene

ICK (Intestinal Cell (MAK-Like) Kinase) is a Protein Coding gene. Diseases associated with ICK include endocrine-cerebroosteodysplasia. GO annotations related to this gene include protein serine/threonine kinase activity and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is MOK.

UniProtKB/Swiss-Prot for ICK Gene

  • Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity).

Gene Wiki entry for ICK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICK Gene

Genomics for ICK Gene

Regulatory Elements for ICK Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ICK Gene

53,001,279 bp from pter
53,061,802 bp from pter
60,524 bases
Minus strand

Genomic View for ICK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ICK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICK Gene

Proteins for ICK Gene

  • Protein details for ICK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase ICK
    Protein Accession:
    Secondary Accessions:
    • A7MD41
    • O75985
    • Q5THL2
    • Q8IYH8
    • Q9BX17
    • Q9NYX3

    Protein attributes for ICK Gene

    632 amino acids
    Molecular mass:
    71427 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    • Sequence=BAA76780.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ICK Gene


neXtProt entry for ICK Gene

Proteomics data for ICK Gene at MOPED

Selected DME Specific Peptides for ICK Gene

Post-translational modifications for ICK Gene

  • Autophosphorylated on serine and threonine residues. May play a role in enzyme activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ICK Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for ICK Gene

Gene Families for ICK Gene

Suggested Antigen Peptide Sequences for ICK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9UPZ9
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with ICK: view

Function for ICK Gene

Molecular function for ICK Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity).

Enzyme Numbers (IUBMB) for ICK Gene

Gene Ontology (GO) - Molecular Function for ICK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 10699974
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 10699974
GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with ICK: view
genes like me logo Genes that share phenotypes with ICK: view

Animal Model Products

CRISPR Products

miRNA for ICK Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ICK

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ICK Gene

Localization for ICK Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICK Gene

Nucleus. Cytoplasm, cytosol. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Also found at the ciliary tip (PubMed:24797473). Nuclear localization has been observed with a GFP-tagged construct in transfected HeLa cells (PubMed:12103360). {ECO:0000250 UniProtKB:Q62726, ECO:0000250 UniProtKB:Q9JKV2, ECO:0000269 PubMed:12103360, ECO:0000269 PubMed:24797473}.

Subcellular locations from

Jensen Localization Image for ICK Gene COMPARTMENTS Subcellular localization image for ICK gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ICK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol IEA --
GO:0036064 ciliary basal body ISS --
GO:0097542 ciliary tip IMP 24797473
genes like me logo Genes that share ontologies with ICK: view

Pathways for ICK Gene

SuperPathways for ICK Gene

No Data Available

Gene Ontology (GO) - Biological Process for ICK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 10699974
GO:0007165 signal transduction TAS 10699974
GO:0007275 multicellular organismal development IEA --
GO:0035556 intracellular signal transduction IDA 10699974
GO:0042073 intraciliary transport ISS --
genes like me logo Genes that share ontologies with ICK: view

No data available for Pathways by source for ICK Gene

Compounds for ICK Gene

(3) HMDB Compounds for ICK Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
  • Magnesium
genes like me logo Genes that share compounds with ICK: view

Transcripts for ICK Gene

Unigene Clusters for ICK Gene

Intestinal cell (MAK-like) kinase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ICK

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ICK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ICK Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c · 16d
SP1: - - - - -
SP2: - - - - - -
SP3: -
SP4: -
SP5: - -

Relevant External Links for ICK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ICK Gene

mRNA expression in normal human tissues for ICK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ICK Gene

SOURCE GeneReport for Unigene cluster for ICK Gene Hs.417022

mRNA Expression by UniProt/SwissProt for ICK Gene

Tissue specificity: Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon, with highest levels in placenta and testis. Not detected in spleen. Also expressed in many cancer cell lines.
genes like me logo Genes that share expressions with ICK: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ICK Gene

Orthologs for ICK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ICK Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ICK 35
  • 99.58 (n)
  • 99.21 (a)
ICK 36
  • 99 (a)
(Bos Taurus)
Mammalia ICK 35
  • 88.43 (n)
  • 92.04 (a)
ICK 36
  • 92 (a)
(Canis familiaris)
Mammalia ICK 35
  • 89.4 (n)
  • 92.25 (a)
ICK 36
  • 93 (a)
(Mus musculus)
Mammalia Ick 35
  • 84.74 (n)
  • 86.8 (a)
Ick 16
Ick 36
  • 87 (a)
(Monodelphis domestica)
Mammalia ICK 36
  • 85 (a)
(Rattus norvegicus)
Mammalia Ick 35
  • 84.63 (n)
  • 86.01 (a)
(Gallus gallus)
Aves ICK 35
  • 74.99 (n)
  • 75.85 (a)
ICK 36
  • 75 (a)
(Anolis carolinensis)
Reptilia ICK 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ick 35
  • 63.9 (n)
  • 62.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42366 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea dyf-5 36
  • 46 (a)
M04C9.5 37
  • 67 (a)
H01G02.2 37
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IME2 36
  • 23 (a)
IME2 38
(Hordeum vulgare)
Liliopsida Hv.1455 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8284 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 70 (a)
Species with no ortholog for ICK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ICK Gene

Gene Tree for ICK (if available)
Gene Tree for ICK (if available)

Paralogs for ICK Gene

Paralogs for ICK Gene

Selected SIMAP similar genes for ICK Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ICK: view

Variants for ICK Gene

Sequence variations from dbSNP and Humsavar for ICK Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs10950 -- 53,001,489(+) ATTGT(C/T)GGTTA utr-variant-3-prime
rs150833 -- 53,038,384(-) tgctc(A/G)gtagc intron-variant
rs150834 -- 53,032,328(-) CATGC(A/T)GGTGT intron-variant
rs150835 -- 53,023,340(-) CAAGA(A/G)TATAT intron-variant
rs160629 -- 53,037,889(-) AGCTT(C/T)GTACA intron-variant

Relevant External Links for ICK Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ICK Gene

Disorders for ICK Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ICK Gene including...

Search for ICK Gene in MalaCards »

(1) OMIM Diseases for ICK Gene (612325)


  • Endocrine-cerebroosteodysplasia (ECO) [MIM:612651]: Previously unidentified neonatal lethal recessive disorder with multiple anomalies involving the endocrine, cerebral, and skeletal systems. {ECO:0000269 PubMed:19185282}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for ICK Gene

Relevant External Links for ICK

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ICK: view

Publications for ICK Gene

  1. Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases. (PMID: 10699974) Togawa K. … Rustgi A.K. (J. Cell. Physiol. 2000) 3 4 23
  2. A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems. (PMID: 19185282) Lahiry P. … Hegele R.A. (Am. J. Hum. Genet. 2009) 3 4 23
  3. The identification and subcellular localization of human MRK. (PMID: 12103360) Yang T. … Chen J. (Biomol. Eng. 2002) 2 3 4
  4. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  5. The promoter for intestinal cell kinase is head-to-head with F-Box 9 and contains functional sites for TCF7L2 and FOXA factors. (PMID: 20459822) Sturgill T.W. … Mayo M.W. (Mol. Cancer 2010) 3 23

Products for ICK Gene

Sources for ICK Gene

Back to Top