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Aliases for ICK Gene

Aliases for ICK Gene

  • Intestinal Cell (MAK-Like) Kinase 2 3 5
  • Laryngeal Cancer Kinase 2 3 4
  • MAK-Related Kinase 3 4
  • EC 2.7.11.22 4 63
  • LCK2 3 4
  • HICK 3 4
  • MRK 3 4
  • Serine/Threonine Protein Kinase 3
  • Intestinal Cell Kinase 4
  • EC 2.7.11 63
  • KIAA0936 4
  • ECO 3

External Ids for ICK Gene

Previous GeneCards Identifiers for ICK Gene

  • GC06M052868
  • GC06M052912
  • GC06M052974
  • GC06M052698

Summaries for ICK Gene

Entrez Gene Summary for ICK Gene

  • Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for ICK Gene

ICK (Intestinal Cell (MAK-Like) Kinase) is a Protein Coding gene. Diseases associated with ICK include endocrine-cerebroosteodysplasia and endemic typhus. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MOK.

UniProtKB/Swiss-Prot for ICK Gene

  • Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity).

Gene Wiki entry for ICK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICK Gene

Genomics for ICK Gene

Regulatory Elements for ICK Gene

Promoters for ICK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ICK on UCSC Golden Path with GeneCards custom track

Genomic Location for ICK Gene

Chromosome:
6
Start:
53,001,279 bp from pter
End:
53,061,833 bp from pter
Size:
60,555 bases
Orientation:
Minus strand

Genomic View for ICK Gene

Genes around ICK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICK Gene

Proteins for ICK Gene

  • Protein details for ICK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPZ9-ICK_HUMAN
    Recommended name:
    Serine/threonine-protein kinase ICK
    Protein Accession:
    Q9UPZ9
    Secondary Accessions:
    • A7MD41
    • O75985
    • Q5THL2
    • Q8IYH8
    • Q9BX17
    • Q9NYX3

    Protein attributes for ICK Gene

    Size:
    632 amino acids
    Molecular mass:
    71427 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76780.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ICK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ICK Gene

Proteomics data for ICK Gene at MOPED

Selected DME Specific Peptides for ICK Gene

Post-translational modifications for ICK Gene

  • Autophosphorylated on serine and threonine residues. May play a role in enzyme activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ICK Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for ICK Gene

Gene Families for ICK Gene

Suggested Antigen Peptide Sequences for ICK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UPZ9

UniProtKB/Swiss-Prot:

ICK_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with ICK: view

Function for ICK Gene

Molecular function for ICK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity).

Enzyme Numbers (IUBMB) for ICK Gene

Gene Ontology (GO) - Molecular Function for ICK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 10699974
GO:0004672 protein kinase activity IEA --
genes like me logo Genes that share ontologies with ICK: view
genes like me logo Genes that share phenotypes with ICK: view

Human Phenotype Ontology for ICK Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ICK Gene

MGI Knock Outs for ICK:
  • Ick tm1a(KOMP)Mbp

Animal Model Products

  • Taconic Biosciences Mouse Models for ICK

No data available for Transcription Factor Targets and HOMER Transcription for ICK Gene

Localization for ICK Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICK Gene

Nucleus. Cytoplasm, cytosol. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Also found at the ciliary tip (PubMed:24797473). Nuclear localization has been observed with a GFP-tagged construct in transfected HeLa cells (PubMed:12103360). {ECO:0000250 UniProtKB:Q62726, ECO:0000250 UniProtKB:Q9JKV2, ECO:0000269 PubMed:12103360, ECO:0000269 PubMed:24797473}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ICK Gene COMPARTMENTS Subcellular localization image for ICK gene
Compartment Confidence
cytoskeleton 4
cytosol 4
nucleus 4
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ICK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0097542 ciliary tip IEA,IMP 24797473
genes like me logo Genes that share ontologies with ICK: view

Pathways & Interactions for ICK Gene

SuperPathways for ICK Gene

No Data Available

SIGNOR curated interactions for ICK Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ICK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 10699974
GO:0007165 signal transduction TAS 10699974
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with ICK: view

No data available for Pathways by source for ICK Gene

Drugs & Compounds for ICK Gene

(2) Drugs for ICK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for ICK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with ICK: view

Transcripts for ICK Gene

Unigene Clusters for ICK Gene

Intestinal cell (MAK-like) kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ICK Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c · 16d
SP1: - - - - -
SP2: - - - - - -
SP3: -
SP4: -
SP5: - -
SP6:

Relevant External Links for ICK Gene

GeneLoc Exon Structure for
ICK
ECgene alternative splicing isoforms for
ICK

Expression for ICK Gene

mRNA expression in normal human tissues for ICK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ICK Gene

This gene is overexpressed in Synovial fluid (66.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ICK Gene



SOURCE GeneReport for Unigene cluster for ICK Gene Hs.417022

mRNA Expression by UniProt/SwissProt for ICK Gene

Q9UPZ9-ICK_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon, with highest levels in placenta and testis. Not detected in spleen. Also expressed in many cancer cell lines.
genes like me logo Genes that share expression patterns with ICK: view

Protein tissue co-expression partners for ICK Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ICK Gene

Orthologs for ICK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ICK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ICK 35
  • 88.43 (n)
  • 92.04 (a)
ICK 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ICK 35
  • 89.4 (n)
  • 92.25 (a)
ICK 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ick 35
  • 84.74 (n)
  • 86.8 (a)
Ick 16
Ick 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ICK 35
  • 99.58 (n)
  • 99.21 (a)
ICK 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ick 35
  • 84.63 (n)
  • 86.01 (a)
oppossum
(Monodelphis domestica)
Mammalia ICK 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves ICK 35
  • 74.99 (n)
  • 75.85 (a)
ICK 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ICK 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ick 35
  • 63.9 (n)
  • 62.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42366 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea H01G02.2 37
  • 33 (a)
M04C9.5 37
  • 67 (a)
dyf-5 36
  • 46 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IME2 36
  • 23 (a)
OneToMany
IME2 38
barley
(Hordeum vulgare)
Liliopsida Hv.1455 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8284 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 70 (a)
OneToMany
Species with no ortholog for ICK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ICK Gene

ENSEMBL:
Gene Tree for ICK (if available)
TreeFam:
Gene Tree for ICK (if available)

Paralogs for ICK Gene

Paralogs for ICK Gene

(18) SIMAP similar genes for ICK Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ICK: view

Variants for ICK Gene

Sequence variations from dbSNP and Humsavar for ICK Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_042001 A renal clear cell carcinoma sample
rs33936662 - 53,013,856(+) TGGGA(A/C/T)TGGCT reference, missense
rs56164633 - 53,011,849(+) ATGAC(A/G/T)TCTGG reference, missense
rs55895113 - 53,011,834(+) TGTCT(C/T)GCCGC reference, missense
rs55932059 - 53,005,205(+) CTGGG(A/C/G/T)GGCTG reference, missense

Variation tolerance for ICK Gene

Residual Variation Intolerance Score: 13.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.26; 62.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ICK Gene

HapMap Linkage Disequilibrium report
ICK
Human Gene Mutation Database (HGMD)
ICK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ICK Gene

Disorders for ICK Gene

MalaCards: The human disease database

(4) MalaCards diseases for ICK Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
endocrine-cerebroosteodysplasia
  • endocrine-cerebro-osteodysplasia syndrome
endemic typhus
  • cat flea rickettsiosis
epulis
  • epulides
tinea pedis
  • athlete's foot
- elite association - COSMIC cancer census association via MalaCards
Search ICK in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ICK_HUMAN
  • Endocrine-cerebroosteodysplasia (ECO) [MIM:612651]: Previously unidentified neonatal lethal recessive disorder with multiple anomalies involving the endocrine, cerebral, and skeletal systems. {ECO:0000269 PubMed:19185282}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ICK

Genetic Association Database (GAD)
ICK
Human Genome Epidemiology (HuGE) Navigator
ICK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ICK
genes like me logo Genes that share disorders with ICK: view

No data available for Genatlas for ICK Gene

Publications for ICK Gene

  1. The identification and subcellular localization of human MRK. (PMID: 12103360) Yang T. … Chen J. (Biomol. Eng. 2002) 2 3 4 67
  2. The promoter for intestinal cell kinase is head-to-head with F-Box 9 and contains functional sites for TCF7L2 and FOXA factors. (PMID: 20459822) Sturgill T.W. … Mayo M.W. (Mol. Cancer 2010) 3 23
  3. A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems. (PMID: 19185282) Lahiry P. … Hegele R.A. (Am. J. Hum. Genet. 2009) 3 23
  4. Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase. (PMID: 16954377) Fu Z. … Sturgill T.W. (Mol. Cell. Biol. 2006) 3 23
  5. Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases. (PMID: 10699974) Togawa K. … Rustgi A.K. (J. Cell. Physiol. 2000) 3 23

Products for ICK Gene

Sources for ICK Gene

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