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Aliases for ICK Gene

Aliases for ICK Gene

  • Intestinal Cell Kinase 2 3 4 5
  • MAK-Related Kinase 2 3 4
  • Serine/Threonine-Protein Kinase ICK 2 3
  • Intestinal Cell (MAK-Like) Kinase 2 3
  • Laryngeal Cancer Kinase 2 3 4
  • LCK2 3 4
  • HICK 3 4
  • MRK 3 4
  • Serine/Threonine Protein Kinase 3
  • EC 2.7.11.22 61
  • EC 2.7.11.1 4
  • EC 2.7.11 61
  • KIAA0936 4
  • ECO 3

External Ids for ICK Gene

Previous GeneCards Identifiers for ICK Gene

  • GC06M052868
  • GC06M052912
  • GC06M052974
  • GC06M052698

Summaries for ICK Gene

Entrez Gene Summary for ICK Gene

  • Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for ICK Gene

ICK (Intestinal Cell Kinase) is a Protein Coding gene. Diseases associated with ICK include Endocrine-Cerebroosteodysplasia and Ovarian Embryonal Carcinoma. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAK.

UniProtKB/Swiss-Prot for ICK Gene

  • Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity (By similarity).

Gene Wiki entry for ICK Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICK Gene

Genomics for ICK Gene

Regulatory Elements for ICK Gene

Enhancers for ICK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G052992 1.4 ENCODE dbSUPER 16.2 +66.8 66792 4.1 CREB3L1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ICK GSTA3 GSTA4 GC06P052982
GH06G053032 1.1 Ensembl ENCODE dbSUPER 16.8 +27.4 27390 4.0 L3MBTL2 ATF2 FOSL1 ZFHX2 GATA2 PBX2 FOS EGR2 ICK GC06P053034 FBXO9
GH06G053009 1.1 ENCODE dbSUPER 15.8 +48.6 48649 7.1 HDAC1 PKNOX1 FOXA2 NFIB SIN3A ZBTB40 RAD21 GATA2 FOS RCOR1 ICK FBXO9 GC06P053016 ENSG00000202198 RN7SK
GH06G052814 1.1 Ensembl ENCODE 10.5 +246.4 246397 1.0 ELF3 FOXA2 ARID4B DMAP1 ZSCAN9 RAD21 RARA YY1 ZNF143 CREM GSTA1 GSTA3 ICK GSTA6P PIR38149
GH06G053111 0.8 ENCODE 14.1 -50.9 -50942 1.8 ELF3 PKNOX1 FOXA2 NFIB SIN3A FOS CREM HMG20B SP5 CEBPB ICK ENSG00000261745 PIR53393
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ICK on UCSC Golden Path with GeneCards custom track

Promoters for ICK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000197984 433 2001 HNRNPUL1 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for ICK Gene

Chromosome:
6
Start:
53,001,279 bp from pter
End:
53,061,833 bp from pter
Size:
60,555 bases
Orientation:
Minus strand

Genomic View for ICK Gene

Genes around ICK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICK Gene

Proteins for ICK Gene

  • Protein details for ICK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPZ9-ICK_HUMAN
    Recommended name:
    Serine/threonine-protein kinase ICK
    Protein Accession:
    Q9UPZ9
    Secondary Accessions:
    • A7MD41
    • O75985
    • Q5THL2
    • Q8IYH8
    • Q9BX17
    • Q9NYX3

    Protein attributes for ICK Gene

    Size:
    632 amino acids
    Molecular mass:
    71427 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA76780.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ICK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ICK Gene

Selected DME Specific Peptides for ICK Gene

Q9UPZ9:
  • YSSPIDVWAVG
  • PKKRPTA
  • VHGRTDW
  • LKPENLL
  • RDLKPEN
  • TRWYRAPE

Post-translational modifications for ICK Gene

  • Autophosphorylated on serine and threonine residues. May play a role in enzyme activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for ICK Gene

Gene Families for ICK Gene

Suggested Antigen Peptide Sequences for ICK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UPZ9

UniProtKB/Swiss-Prot:

ICK_HUMAN :
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
genes like me logo Genes that share domains with ICK: view

Function for ICK Gene

Molecular function for ICK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Required for ciliogenesis (PubMed:24797473). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a key role in the development of multiple organ systems and particularly in cardiac development (By similarity). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity (By similarity).

Enzyme Numbers (IUBMB) for ICK Gene

Gene Ontology (GO) - Molecular Function for ICK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 10699974
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IDA 10699974
GO:0005515 protein binding IPI 22939624
GO:0005524 ATP binding IDA 10699974
genes like me logo Genes that share ontologies with ICK: view
genes like me logo Genes that share phenotypes with ICK: view

Human Phenotype Ontology for ICK Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ICK Gene

MGI Knock Outs for ICK:
  • Ick tm1a(KOMP)Mbp

Animal Model Products

  • Taconic Biosciences Mouse Models for ICK

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for ICK Gene

Localization for ICK Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICK Gene

Nucleus. Cytoplasm, cytosol. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Also found at the ciliary tip (PubMed:24797473). Nuclear localization has been observed with a GFP-tagged construct in transfected HeLa cells (PubMed:12103360). {ECO:0000269 PubMed:12103360, ECO:0000269 PubMed:24797473}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ICK gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 4
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ICK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IBA --
GO:0005737 cytoplasm IEA,IBA --
GO:0005829 cytosol IEA --
GO:0005856 cytoskeleton IEA --
GO:0005929 cilium ISS --
genes like me logo Genes that share ontologies with ICK: view

Pathways & Interactions for ICK Gene

No Data Available

SIGNOR curated interactions for ICK Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ICK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 10699974
GO:0007165 signal transduction TAS 10699974
GO:0007275 multicellular organism development IEA --
GO:0010468 regulation of gene expression IBA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with ICK: view

No data available for Pathways by source for ICK Gene

Drugs & Compounds for ICK Gene

(2) Drugs for ICK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for ICK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with ICK: view

Transcripts for ICK Gene

Unigene Clusters for ICK Gene

Intestinal cell (MAK-like) kinase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ICK Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c · 16d
SP1: - - - - -
SP2: - - - - - -
SP3: -
SP4: -
SP5: - -
SP6:

Relevant External Links for ICK Gene

GeneLoc Exon Structure for
ICK
ECgene alternative splicing isoforms for
ICK

Expression for ICK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ICK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ICK Gene

This gene is overexpressed in Synovial fluid (66.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ICK Gene



Protein tissue co-expression partners for ICK Gene

NURSA nuclear receptor signaling pathways regulating expression of ICK Gene:

ICK

SOURCE GeneReport for Unigene cluster for ICK Gene:

Hs.417022

mRNA Expression by UniProt/SwissProt for ICK Gene:

Q9UPZ9-ICK_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon, with highest levels in placenta and testis. Not detected in spleen. Also expressed in many cancer cell lines.

Evidence on tissue expression from TISSUES for ICK Gene

  • Nervous system(2.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ICK Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • cerebellum
  • cerebrospinal fluid
  • cheek
  • chin
  • ear
  • face
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • meninges
  • mouth
  • nose
  • outer ear
  • skull
Thorax:
  • breast
  • chest wall
  • rib
  • rib cage
  • sternum
Abdomen:
  • adrenal gland
Pelvis:
  • penis
  • testicle
  • urethra
  • vagina
  • vulva
Limb:
  • arm
  • digit
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • humerus
  • lower limb
  • radius
  • shin
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
General:
  • skin
genes like me logo Genes that share expression patterns with ICK: view

Primer Products

No data available for mRNA differential expression in normal tissues for ICK Gene

Orthologs for ICK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ICK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ICK 34 35
  • 99.58 (n)
dog
(Canis familiaris)
Mammalia ICK 34 35
  • 89.4 (n)
cow
(Bos Taurus)
Mammalia ICK 34 35
  • 88.43 (n)
oppossum
(Monodelphis domestica)
Mammalia ICK 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ick 34 16 35
  • 84.74 (n)
rat
(Rattus norvegicus)
Mammalia Ick 34
  • 84.63 (n)
chicken
(Gallus gallus)
Aves ICK 34 35
  • 74.99 (n)
lizard
(Anolis carolinensis)
Reptilia ICK 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ick 34
  • 63.9 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG42366 35
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M04C9.5 36
  • 67 (a)
dyf-5 35
  • 46 (a)
OneToMany
H01G02.2 36
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IME2 35 37
  • 23 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.1455 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 70 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8284 34
Species where no ortholog for ICK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for ICK Gene

ENSEMBL:
Gene Tree for ICK (if available)
TreeFam:
Gene Tree for ICK (if available)

Paralogs for ICK Gene

Paralogs for ICK Gene

(18) SIMAP similar genes for ICK Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ICK: view

Variants for ICK Gene

Sequence variations from dbSNP and Humsavar for ICK Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs118203918 Pathogenic, Endocrine-cerebroosteodysplasia (ECO) [MIM:612651] 53,016,099(-) GAAAC(A/G)ACCAA reference, missense
VAR_042001 A renal clear cell carcinoma sample
rs138668959 Likely benign 53,018,438(+) CCCAC(C/T)GCCCA reference, synonymous-codon
rs34168889 Likely benign 53,011,842(+) CGCTG(A/G)TATGA reference, synonymous-codon
rs868057037 Uncertain significance 53,016,098(+) GTTGG(A/T)CGTTT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ICK Gene

Variant ID Type Subtype PubMed ID
nsv472194 CNV novel sequence insertion 20440878

Variation tolerance for ICK Gene

Residual Variation Intolerance Score: 13.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.26; 62.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ICK Gene

Human Gene Mutation Database (HGMD)
ICK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ICK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICK Gene

Disorders for ICK Gene

MalaCards: The human disease database

(3) MalaCards diseases for ICK Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
endocrine-cerebroosteodysplasia
  • endocrine-cerebro-osteodysplasia syndrome
ovarian embryonal carcinoma
  • embryonal carcinoma of ovary
hydrolethalus syndrome
  • salonen-herva-norio syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ICK in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ICK_HUMAN
  • Endocrine-cerebroosteodysplasia (ECO) [MIM:612651]: Previously unidentified neonatal lethal recessive disorder with multiple anomalies involving the endocrine, cerebral, and skeletal systems. {ECO:0000269 PubMed:19185282, ECO:0000269 PubMed:24797473, ECO:0000269 PubMed:24853502}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ICK

Genetic Association Database (GAD)
ICK
Human Genome Epidemiology (HuGE) Navigator
ICK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ICK
genes like me logo Genes that share disorders with ICK: view

No data available for Genatlas for ICK Gene

Publications for ICK Gene

  1. A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems. (PMID: 19185282) Lahiry P. … Hegele R.A. (Am. J. Hum. Genet. 2009) 3 4 22 64
  2. The identification and subcellular localization of human MRK. (PMID: 12103360) Yang T. … Chen J. (Biomol. Eng. 2002) 2 3 4 64
  3. Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases. (PMID: 10699974) Togawa K. … Rustgi A.K. (J. Cell. Physiol. 2000) 3 4 22 64
  4. ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport. (PMID: 24797473) Chaya T. … Furukawa T. (EMBO J. 2014) 3 4 64
  5. The promoter for intestinal cell kinase is head-to-head with F-Box 9 and contains functional sites for TCF7L2 and FOXA factors. (PMID: 20459822) Sturgill T.W. … Mayo M.W. (Mol. Cancer 2010) 3 22 64

Products for ICK Gene

Sources for ICK Gene

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