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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ICK Gene

protein-coding   GIFtS: 60
GCID: GC06M052912

Intestinal Cell (MAK-Like) Kinase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Intestinal Cell (MAK-Like) Kinase1 2     ECO2 5
MRK2 3 5     KIAA09363 5
Laryngeal Cancer Kinase 22 3     Serine/Threonine Protein Kinase2
LCK22 3     Serine/Threonine-Protein Kinase ICK2
hICK2 3     Intestinal Cell Kinase3
MAK-Related Kinase2 3     EC 2.7.118
EC 2.7.11.223 8     

External Ids:    HGNC: 212191   Entrez Gene: 228582   Ensembl: ENSG000001121447   OMIM: 6123255   UniProtKB: Q9UPZ93   

Export aliases for ICK gene to outside databases

Previous GC identifers: GC06M052868 GC06M052974 GC06M052698


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ICK Gene:
Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved
catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal
serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases.
The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell
proliferation and differentiation. Alternative splicing has been observed at this locus and two variants,
encoding the same isoform, have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for ICK Gene: 
ICK (intestinal cell (MAK-like) kinase) is a protein-coding gene. Diseases associated with ICK include endocrine-cerebroosteodysplasia, and laryngitis. GO annotations related to this gene include protein serine/threonine kinase activity and cyclin-dependent protein serine/threonine kinase activity. An important paralog of this gene is MOK.

UniProtKB/Swiss-Prot: ICK_HUMAN, Q9UPZ9
Function: May play a key role in the development of multiple organ systems and particularly in cardiac development
(By similarity)

Gene Wiki entry for ICK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ICK gene promoter:
         Brachyury   GCNF   STAT5A   Ik-3   RORalpha2   SRY   HFH-1   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidICK promoter sequence
   Search SABiosciences Chromatin IP Primers for ICK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ICK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.1   Ensembl cytogenetic band:  6p12.1   HGNC cytogenetic band: 6p12.3-p11.2

ICK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ICK gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M052912:  view genomic region     (about GC identifiers)

Start:
52,866,077 bp from pter      End:
52,926,600 bp from pter
Size:
60,524 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ICK_HUMAN, Q9UPZ9 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase ICK  
Size: 632 amino acids; 71427 Da
Cofactor: Magnesium
Subcellular location: Nucleus. Cytoplasm, cytosol (By similarity). Note=Nuclear localization has been observed
with a GFP-tagged construct in transfected HeLa cells (PubMed:12103360). Cytosolic localization was shown in rat
embryonic cardiomyocytes by immunostaining (PubMed:8570168)
Sequence caution: Sequence=BAA76780.2; Type=Erroneous initiation;
Secondary accessions: A7MD41 O75985 Q5THL2 Q8IYH8 Q9BX17 Q9NYX3
Alternative splicing: 2 isoforms:  Q9UPZ9-1   Q9UPZ9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ICK: NX_Q9UPZ9

Explore proteomics data for ICK at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated on serine and threonine residues. May play a role in enzyme activation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UPZ9

  • 4/6 DME Specific Peptides for ICK (Q9UPZ9) (see all 6)
     LKPENLL  VHGRTDW  RDLKPEN  PKKRPTA 

    ICK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ICK Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_055735.1  NP_057597.2  

    ENSEMBL proteins: 
     ENSP00000263043   ENSP00000349458  

    Human Recombinant Protein Products for ICK: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for ICK 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    ICK for ontologies           About GeneDecksing



    ICK Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: intestinal cell (MAK-like) kinase 
    RCK family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9UPZ9

    ProtoNet protein and cluster: Q9UPZ9

    UniProtKB/Swiss-Prot: ICK_HUMAN, Q9UPZ9
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily
    Similarity: Contains 1 protein kinase domain


    ICK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ICK_HUMAN, Q9UPZ9
    Function: May play a key role in the development of multiple organ systems and particularly in cardiac development
    (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.221 2 EC 2.7.112

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA10699974
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA10699974
    GO:0004693cyclin-dependent protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
         
    ICK for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for ICK:
     Decreased substrate adherent c  Increased cell death HMECs cel  Synthetic lethal with Ras  Wnt reporter downregulated 

         1 MGI phenotypic allele for Ick (no phenotypes)

    ICK for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ICK 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ICK 
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ICK
    8/82 QIAGEN miScript miRNA Assays for microRNAs that regulate ICK (see all 82):
    hsa-miR-3130-5p hsa-miR-3607-3p hsa-miR-607 hsa-miR-300 hsa-miR-485-3p hsa-miR-374a hsa-miR-30d hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidICK 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICK


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ICK

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/40 Interacting proteins for ICK (Q9UPZ91, 2, 3 ENSP000002630434) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD1Q157972, 3MINT-62019 I2D: score=3 
    ATP6V0D1P614213I2D: score=5 
    CCT2P783713I2D: score=4 
    TCP1P179873I2D: score=4 
    FZR1Q9UM113I2D: score=3 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA10699974
    GO:0007165signal transduction TAS10699974
    GO:0007243intracellular protein kinase cascade IDA10699974
    GO:0007275multicellular organismal development IEA--

    ICK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ICK

    3 HMDB Compounds for ICK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    Search CenterWatch for drugs/clinical trials and news about ICK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ICK gene (2 alternative transcripts): 
    NM_014920.3  NM_016513.4  

    Unigene Cluster for ICK:

    Intestinal cell (MAK-like) kinase
    Hs.417022  [show with all ESTs]
    Unigene Representative Sequence: NM_016513
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000350082 ENST00000356971(uc003pbh.2 uc003pbi.2 uc003pbj.3)

    miRNA
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    8/82 QIAGEN miScript miRNA Assays for microRNAs that regulate ICK (see all 82):
    hsa-miR-3130-5p hsa-miR-3607-3p hsa-miR-607 hsa-miR-300 hsa-miR-485-3p hsa-miR-374a hsa-miR-30d hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidICK 3' UTR sequence
    Inhib. RNA
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    Clone
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ICK

    Additional mRNA sequence: 

    AB023153.1 AF152469.1 AF225919.1 AJ420557.1 AK074892.1 BC035807.1 BC136420.1 BC136421.1 
    BC152464.1 BX647493.1 

    8 DOTS entries:

    DT.95372370  DT.115329  DT.100663013  DT.100018316  DT.40195675  DT.100805092  DT.92426700  DT.92426701 

    24/127 AceView cDNA sequences (see all 127):

    BU186351 CD245100 BX284015 Z42402 AA733178 AI560203 AA736840 BM464463 
    NM_014920 AI468694 AI277911 BG681441 AL600198 BM128705 CA312371 AA047491 
    BQ440526 AA908456 BM802745 BF514365 BC035807 BM932175 AK074892 CB128950 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ICK (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c · 16d
    SP1:        -                 -                                         -                       -           -                                 
    SP2:        -     -           -                                         -                       -           -                                 
    SP3:                          -                                                                                                               
    SP4:                                                                                                        -                                 
    SP5:        -     -                                                                                                                           


    ECgene alternative splicing isoforms for ICK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ICK expression in normal human tissues (normalized intensities)      ICK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ICK Expression
    About this image


    ICK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Adrenal Gland (Endocrine System)
             adrenal cortex   
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow

    See ICK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ICK

    SOURCE GeneReport for Unigene cluster: Hs.417022

    UniProtKB/Swiss-Prot: ICK_HUMAN, Q9UPZ9
    Tissue specificity: Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small
    intestine and colon, with highest levels in placenta and testis. Not detected in spleen. Also expressed in many
    cancer cell lines

        SABiosciences Custom PCR Arrays for ICK
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ICK gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ick1 , 5 intestinal cell kinase1, 5 84.74(n)1
    86.8(a)1
      9 (43.56 cM)5
    565421  NM_001163780.11  NP_001157252.11 
     781091925 
    chicken
    (Gallus gallus)
    Aves ICK1 intestinal cell (MAK-like) kinase 75.2(n)
    76.17(a)
      421896  XM_419912.3  XP_419912.3 
    lizard
    (Anolis carolinensis)
    Reptilia ICK6
    intestinal cell (MAK-like) kinase
    72(a)
    1 ↔ 1
    1(151668906-151692366)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG423666
    --
    32(a)
    1 → many
    2L(9925161-9930378)
    worm
    (Caenorhabditis elegans)
    Secernentea M04C9.53 serine/threonine kinase (CDC2/CDKX
    subfamily)
    67(a)
    (best of 2)
      I(9367904-9370983)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IME2(YJL106W)4 Serine/threonine protein kinase involved in activation more   --   10(221390-223327) 853338  NP_012429.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g07006001 hypothetical protein 54.66(n)
    51.4(a)
      4330434  NM_001054376.1  NP_001047841.1 


    ENSEMBL Gene Tree for ICK (if available)
    TreeFam Gene Tree for ICK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ICK gene
    MOK2  MAK2  
    18 SIMAP similar genes for ICK using alignment to 1 protein entry:     ICK_HUMAN:
    MAK    CDK2    CDK3    CDK10    CDK7    MOK
    CDK16    PCTK1    CDK4    CDK6    MAPK1    MAPK14
    PRKAA1    MAPK12    CDK9    MAPK11    MAPK13    GSK3B

    ICK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1120 SNPs in ICK are shown (see all 1120)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0579944
    Endocrine-cerebroosteodysplasia (ECO)4--see VAR_0579942 R Q mis40--------
    VAR_0420014
    A renal clear cell carcinoma sample4--see VAR_0420012 F Y mis40--------
    rs1182039181,2
    Cpathogenic152792497(-) GAAACA/GACCAA 4 Q R mis10--------
    rs1926387841,2
    --52777201(+) ACAGGG/TCCTCA 2 -- ds50010--------
    rs1389731401,2
    --52777275(+) GCTCAA/GGTGAT 2 -- ds50010--------
    rs1842228031,2
    --52777420(+) CCTCAC/TGCCTC 2 -- ds50010--------
    rs93821671,2
    A--52777435(+) tcccaA/Gagtgc 2 -- ds50010--------
    rs1879489841,2
    --52777440(+) GAGTGA/CCGGGA 2 -- ds50010--------
    rs23971351,2
    C,F,A,H--52777502(+) TTTAAC/AAAAAC 2 -- ds500113Minor allele frequency- A:0.28NS EA NA WA 922
    rs23971361,2
    C,F,A,H--52777514(+) TCCACA/GTTGCA 2 -- ds500119Minor allele frequency- G:0.21NS EA NA WA CSA 2344

    HapMap Linkage Disequilibrium report for ICK (52866077 - 52926600 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ICK: --

    Human Gene Mutation Database (HGMD): ICK
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ICK
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612325   
    OMIM disorders: 612651  
    UniProtKB/Swiss-Prot: ICK_HUMAN, Q9UPZ9
  • Endocrine-cerebroosteodysplasia (ECO) [MIM:612651]: Previously unidentified neonatal lethal recessive
    disorder with multiple anomalies involving the endocrine, cerebral, and skeletal systems. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • 6 diseases for ICK:    About MalaCards
    endocrine-cerebroosteodysplasia    laryngitis    ehrlichiosis    keratopathy
    cerebritis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for ICK:
    Ehrlichiosis

    ICK for disorders           About GeneDecksing

    Genetic Association Database (GAD): ICK
    Human Genome Epidemiology (HuGE) Navigator: ICK (1 document)

    Export disorders for ICK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ICK gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with ICK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The identification and subcellular localization of human MRK. (PubMed id 12103360)1, 2, 3 Yang T.... Chen J. (2002)
    2. Intestinal cell kinase (ICK) localizes to the crypt region and requires a dual phosphorylation site found in map kinases. (PubMed id 10699974)1, 2, 9 Togawa K.... Rustgi A.K. (2000)
    3. A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems. (PubMed id 19185282)1, 2, 9 Lahiry P.... Hegele R.A. (2009)
    4. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    7. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (1999)
    8. Identification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase. (PubMed id 16954377)1, 9 Fu Z....Sturgill T.W. (2006)
    9. The promoter for intestinal cell kinase is head-to-he ad with F-Box 9 and contains functional sites for TCF7L2 and FOXA factors. (PubMed id 20459822)1, 9 Sturgill T.W....Mayo M.W. (2010)
    10. VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22858 HGNC: 21219 AceView: ICK Ensembl:ENSG00000112144 euGenes: HUgn22858
    ECgene: ICK H-InvDB: ICK

    (According to HUGE)
    About This Section
    HUGE: KIAA0936

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ICK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ICK gene:
    Search GeneIP for patents involving ICK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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