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Aliases for ICE2 Gene

Aliases for ICE2 Gene

  • Interactor Of Little Elongation Complex ELL Subunit 2 2 3 5
  • Interactor Of Little Elongator Complex ELL Subunit 2 3 4
  • NMDA Receptor-Regulated Protein 2 3 4
  • NMDA Receptor Regulated 2 2 3
  • Breast Cancer Cell 1 2 3
  • BRCC1 3 4
  • NARG2 3 4
  • NMDA Receptor-Regulated Gene 2 3

External Ids for ICE2 Gene

Previous HGNC Symbols for ICE2 Gene

  • NARG2

Summaries for ICE2 Gene

GeneCards Summary for ICE2 Gene

ICE2 (Interactor Of Little Elongation Complex ELL Subunit 2) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance.

UniProtKB/Swiss-Prot for ICE2 Gene

  • Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICE2 Gene

Genomics for ICE2 Gene

Regulatory Elements for ICE2 Gene

Enhancers for ICE2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ICE2 on UCSC Golden Path with GeneCards custom track

Promoters for ICE2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ICE2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ICE2 Gene

Chromosome:
15
Start:
60,419,609 bp from pter
End:
60,479,160 bp from pter
Size:
59,552 bases
Orientation:
Minus strand

Genomic View for ICE2 Gene

Genes around ICE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICE2 Gene

Proteins for ICE2 Gene

  • Protein details for ICE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q659A1-ICE2_HUMAN
    Recommended name:
    Little elongation complex subunit 2
    Protein Accession:
    Q659A1
    Secondary Accessions:
    • B2RU08
    • Q05CT1
    • Q3B7W6
    • Q63HP4
    • Q658Q0
    • Q68CN8
    • Q6IPW7
    • Q6UX23
    • Q71H65
    • Q96CY5
    • Q9HAA2

    Protein attributes for ICE2 Gene

    Size:
    982 amino acids
    Molecular mass:
    110011 Da
    Quaternary structure:
    • Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2. Interacts with ICE1 (via C-terminus domain). Interacts with ELL.
    SequenceCaution:
    • Sequence=AAH13684.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH20918.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI07428.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAQ88910.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305}; Sequence=BAB13948.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH18700.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for ICE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ICE2 Gene

Proteomics data for ICE2 Gene at MOPED

Post-translational modifications for ICE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ICE2 Gene

Domains & Families for ICE2 Gene

Protein Domains for ICE2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ICE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q659A1

UniProtKB/Swiss-Prot:

ICE2_HUMAN :
  • Belongs to the ICE2 family.
Family:
  • Belongs to the ICE2 family.
genes like me logo Genes that share domains with ICE2: view

No data available for Gene Families for ICE2 Gene

Function for ICE2 Gene

Molecular function for ICE2 Gene

UniProtKB/Swiss-Prot Function:
Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.
genes like me logo Genes that share phenotypes with ICE2: view

Animal Model Products

miRNA for ICE2 Gene

miRTarBase miRNAs that target ICE2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ICE2 Gene

Localization for ICE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICE2 Gene

Nucleus. Note=Colocalizes with COIL in subnuclear Cajal and histone locus bodies. Translocates in the LEC complex to Cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.

Gene Ontology (GO) - Cellular Components for ICE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0008023 transcription elongation factor complex IMP 22195968
GO:0015030 Cajal body IDA 23932780
genes like me logo Genes that share ontologies with ICE2: view

No data available for Subcellular locations from COMPARTMENTS for ICE2 Gene

Pathways & Interactions for ICE2 Gene

genes like me logo Genes that share pathways with ICE2: view

Pathways by source for ICE2 Gene

Interacting Proteins for ICE2 Gene

Gene Ontology (GO) - Biological Process for ICE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042795 snRNA transcription from RNA polymerase II promoter IMP,TAS --
genes like me logo Genes that share ontologies with ICE2: view

No data available for SIGNOR curated interactions for ICE2 Gene

Drugs & Compounds for ICE2 Gene

No Compound Related Data Available

Transcripts for ICE2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ICE2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: - - -
SP5:
SP6: -
SP7:

Relevant External Links for ICE2 Gene

GeneLoc Exon Structure for
ICE2
ECgene alternative splicing isoforms for
ICE2

Expression for ICE2 Gene

mRNA expression in normal human tissues for ICE2 Gene

Protein differential expression in normal tissues from HIPED for ICE2 Gene

This gene is overexpressed in Plasma (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ICE2 Gene



mRNA Expression by UniProt/SwissProt for ICE2 Gene

Q659A1-ICE2_HUMAN
Tissue specificity: Expressed at low levels in lung and testis.
genes like me logo Genes that share expression patterns with ICE2: view

Protein tissue co-expression partners for ICE2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ICE2 Gene

Orthologs for ICE2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ICE2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NARG2 35
  • 89.88 (n)
  • 87.93 (a)
NARG2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NARG2 35
  • 91.24 (n)
  • 89.06 (a)
NARG2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Narg2 35
  • 82.13 (n)
  • 78.74 (a)
Ice2 16
Narg2 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NARG2 35
  • 99.25 (n)
  • 99.08 (a)
NARG2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Narg2 35
  • 82.98 (n)
  • 80.13 (a)
oppossum
(Monodelphis domestica)
Mammalia NARG2 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NARG2 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves NARG2 35
  • 61.3 (n)
  • 49.89 (a)
NARG2 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NARG2 36
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia narg2 35
  • 52.93 (n)
  • 45.66 (a)
zebrafish
(Danio rerio)
Actinopterygii narg2 35
  • 46.56 (n)
  • 40.21 (a)
narg2 36
  • 30 (a)
OneToOne
Species with no ortholog for ICE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ICE2 Gene

ENSEMBL:
Gene Tree for ICE2 (if available)
TreeFam:
Gene Tree for ICE2 (if available)

Paralogs for ICE2 Gene

Pseudogenes.org Pseudogenes for ICE2 Gene

genes like me logo Genes that share paralogs with ICE2: view

No data available for Paralogs for ICE2 Gene

Variants for ICE2 Gene

Sequence variations from dbSNP and Humsavar for ICE2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs3068 -- 60,423,444(-) CCCTT(A/G)AAGTT nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs5813026 -- 60,420,151(+) TGACT(-/A)AAAAA utr-variant-3-prime
rs5813028 -- 60,458,196(+) GTAGC(-/A)AAAAA intron-variant
rs6494197 -- 60,426,542(+) TGTGT(A/T)ATTGT intron-variant
rs6494198 -- 60,439,272(+) gtaat(C/T)caaaa intron-variant

Variation tolerance for ICE2 Gene

Residual Variation Intolerance Score: 6.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.45% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ICE2 Gene

Disorders for ICE2 Gene

Relevant External Links for ICE2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ICE2

No disorders were found for ICE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ICE2 Gene

Publications for ICE2 Gene

  1. The little elongation complex functions at initiation and elongation phases of snRNA gene transcription. (PMID: 23932780) Hu D. … Shilatifard A. (Mol. Cell 2013) 2 3 4 67
  2. N-methyl-D-aspartate receptors regulate a group of transiently expressed genes in the developing brain. (PMID: 11297529) Sugiura N. … Corriveau R.A. (J. Biol. Chem. 2001) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3

Products for ICE2 Gene

Sources for ICE2 Gene

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