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Aliases for ICE2 Gene

Aliases for ICE2 Gene

  • Interactor Of Little Elongation Complex ELL Subunit 2 2 3 5
  • Interactor Of Little Elongator Complex ELL Subunit 2 3 4
  • NMDA Receptor-Regulated Protein 2 3 4
  • NMDA Receptor Regulated 2 2 3
  • Breast Cancer Cell 1 2 3
  • BRCC1 3 4
  • NARG2 3 4
  • Little Elongation Complex Subunit 2 3
  • NMDA Receptor-Regulated Gene 2 3

External Ids for ICE2 Gene

Previous HGNC Symbols for ICE2 Gene

  • NARG2

Summaries for ICE2 Gene

Entrez Gene Summary for ICE2 Gene

  • This gene encodes a protein component of the little elongation complex (LEC), which plays a role in small nuclear RNA (snRNA) transcription. The LEC regulates snRNA transcription by enhancing both RNA Polymerase II occupancy and transcriptional elongation. The encoded protein and other LEC components have been shown to localize to Cajal bodies, which are sites of ribonucleoprotein (RNP) complex assembly. Pseudogenes of this gene have been identified on chromosomes 3 and 4. [provided by RefSeq, May 2017]

GeneCards Summary for ICE2 Gene

ICE2 (Interactor Of Little Elongation Complex ELL Subunit 2) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA polymerase II transcribes snRNA genes.

UniProtKB/Swiss-Prot for ICE2 Gene

  • Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICE2 Gene

Genomics for ICE2 Gene

Regulatory Elements for ICE2 Gene

Enhancers for ICE2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G060388 1.7 Ensembl ENCODE dbSUPER 19.2 +83.2 83178 15.4 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 NFYC TBX21 ICE2 RPS3AP6 RPL36AP44 RORA-AS1 GC15P060391 ANXA2
GH15G059684 1.7 FANTOM5 ENCODE dbSUPER 14 +791.6 791582 7.1 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 GTF2A2 ICE2 RPS3AP6 BNIP2 ENSG00000259238 PIR36988
GH15G059586 0.8 ENCODE 25.8 +891.6 891583 1.3 JUN SALL2 CTBP1 ZNF316 GATA3 ZNF366 SCRT2 ZNF169 ZNF26 FOS ICE2 MINDY2 RPS3AP6 GCNT3 GC15M059575
GH15G060744 0.8 ENCODE 24.9 -266.4 -266363 1.8 PKNOX1 NFIB INSM2 ZNF195 FEZF1 RAD21 ZNF366 SCRT2 ZNF350 ZIK1 ICE2 RPS3AP6 RNA5SP397 LOC105370844
GH15G061038 0.8 ENCODE 24.8 -559.5 -559457 0.2 PKNOX1 NFIB INSM2 ZNF195 FEZF1 RAD21 ZNF366 SCRT2 ZNF350 ZIK1 ICE2 PIR44161 GC15M060908
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ICE2 on UCSC Golden Path with GeneCards custom track

Promoters for ICE2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000077430 160 1601 HNRNPUL1 HDGF PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for ICE2 Gene

Chromosome:
15
Start:
60,419,609 bp from pter
End:
60,479,160 bp from pter
Size:
59,552 bases
Orientation:
Minus strand

Genomic View for ICE2 Gene

Genes around ICE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICE2 Gene

Proteins for ICE2 Gene

  • Protein details for ICE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q659A1-ICE2_HUMAN
    Recommended name:
    Little elongation complex subunit 2
    Protein Accession:
    Q659A1
    Secondary Accessions:
    • B2RU08
    • Q05CT1
    • Q3B7W6
    • Q63HP4
    • Q658Q0
    • Q68CN8
    • Q6IPW7
    • Q6UX23
    • Q71H65
    • Q96CY5
    • Q9HAA2

    Protein attributes for ICE2 Gene

    Size:
    982 amino acids
    Molecular mass:
    110011 Da
    Quaternary structure:
    • Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2. Interacts with ICE1 (via C-terminus domain). Interacts with ELL.
    SequenceCaution:
    • Sequence=AAH13684.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH20918.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI07428.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAQ88910.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305}; Sequence=BAB13948.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH18700.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for ICE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ICE2 Gene

Post-translational modifications for ICE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ICE2 Gene

Domains & Families for ICE2 Gene

Protein Domains for ICE2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ICE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q659A1

UniProtKB/Swiss-Prot:

ICE2_HUMAN :
  • Belongs to the ICE2 family.
Family:
  • Belongs to the ICE2 family.
genes like me logo Genes that share domains with ICE2: view

No data available for Gene Families for ICE2 Gene

Function for ICE2 Gene

Molecular function for ICE2 Gene

UniProtKB/Swiss-Prot Function:
Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.

Gene Ontology (GO) - Molecular Function for ICE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22195968
genes like me logo Genes that share ontologies with ICE2: view
genes like me logo Genes that share phenotypes with ICE2: view

Animal Model Products

miRNA for ICE2 Gene

miRTarBase miRNAs that target ICE2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ICE2 Gene

Localization for ICE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICE2 Gene

Nucleus. Note=Colocalizes with COIL in subnuclear Cajal and histone locus bodies. Translocates in the LEC complex to Cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ICE2 gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for ICE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol IDA --
GO:0008023 transcription elongation factor complex IMP 22195968
GO:0015030 Cajal body IDA 23932780
genes like me logo Genes that share ontologies with ICE2: view

Pathways & Interactions for ICE2 Gene

genes like me logo Genes that share pathways with ICE2: view

Pathways by source for ICE2 Gene

Gene Ontology (GO) - Biological Process for ICE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0042795 snRNA transcription from RNA polymerase II promoter TAS --
GO:0042796 snRNA transcription from RNA polymerase III promoter IMP 23932780
GO:0045945 positive regulation of transcription from RNA polymerase III promoter IMP 23932780
genes like me logo Genes that share ontologies with ICE2: view

No data available for SIGNOR curated interactions for ICE2 Gene

Drugs & Compounds for ICE2 Gene

No Compound Related Data Available

Transcripts for ICE2 Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ICE2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: - - -
SP5:
SP6: -
SP7:

Relevant External Links for ICE2 Gene

GeneLoc Exon Structure for
ICE2
ECgene alternative splicing isoforms for
ICE2

Expression for ICE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ICE2 Gene

Protein differential expression in normal tissues from HIPED for ICE2 Gene

This gene is overexpressed in Plasma (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ICE2 Gene



Protein tissue co-expression partners for ICE2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ICE2 Gene:

ICE2

mRNA Expression by UniProt/SwissProt for ICE2 Gene:

Q659A1-ICE2_HUMAN
Tissue specificity: Expressed at low levels in lung and testis.

Evidence on tissue expression from TISSUES for ICE2 Gene

  • Nervous system(4.5)
  • Kidney(4.3)
  • Heart(4.2)
  • Liver(4.2)
  • Bone marrow(4.1)
  • Bone(4)
genes like me logo Genes that share expression patterns with ICE2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ICE2 Gene

Orthologs for ICE2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ICE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NARG2 35 34
  • 99.25 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NARG2 34 35
  • 91.24 (n)
cow
(Bos Taurus)
Mammalia NARG2 34 35
  • 89.88 (n)
rat
(Rattus norvegicus)
Mammalia Narg2 34
  • 82.98 (n)
mouse
(Mus musculus)
Mammalia Narg2 34 35
  • 82.13 (n)
Ice2 16
oppossum
(Monodelphis domestica)
Mammalia NARG2 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NARG2 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves NARG2 34 35
  • 61.3 (n)
lizard
(Anolis carolinensis)
Reptilia NARG2 35
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia narg2 34
  • 52.93 (n)
zebrafish
(Danio rerio)
Actinopterygii narg2 34 35
  • 46.56 (n)
Species where no ortholog for ICE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ICE2 Gene

ENSEMBL:
Gene Tree for ICE2 (if available)
TreeFam:
Gene Tree for ICE2 (if available)

Paralogs for ICE2 Gene

Pseudogenes.org Pseudogenes for ICE2 Gene

genes like me logo Genes that share paralogs with ICE2: view

No data available for Paralogs for ICE2 Gene

Variants for ICE2 Gene

Sequence variations from dbSNP and Humsavar for ICE2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs141469235 Benign 60,466,706(+) GTTTT(C/T)TCATA nc-transcript-variant, reference, missense
rs1000023766 -- 60,451,528(+) ACACT(C/T)AGCAA intron-variant, utr-variant-3-prime
rs1000054552 -- 60,465,202(+) CCTTC(A/C)TTTTT intron-variant
rs1000086576 -- 60,479,325(+) GGGGA(A/G)TGATA nc-transcript-variant, upstream-variant-2KB
rs1000093034 -- 60,441,197(+) GTTAC(A/G)GAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ICE2 Gene

Variant ID Type Subtype PubMed ID
esv3581733 CNV loss 25503493
nsv507783 OTHER sequence alteration 20534489
nsv525689 CNV gain 19592680
nsv527607 CNV loss 19592680
nsv569609 CNV loss 21841781
nsv7266 OTHER inversion 18451855

Variation tolerance for ICE2 Gene

Residual Variation Intolerance Score: 6.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ICE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ICE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICE2 Gene

Disorders for ICE2 Gene

Relevant External Links for ICE2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ICE2

No disorders were found for ICE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ICE2 Gene

Publications for ICE2 Gene

  1. The little elongation complex functions at initiation and elongation phases of snRNA gene transcription. (PMID: 23932780) Hu D. … Shilatifard A. (Mol. Cell 2013) 2 3 4 64
  2. The little elongation complex regulates small nuclear RNA transcription. (PMID: 22195968) Smith E.R. … Shilatifard A. (Mol. Cell 2011) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. NARG2 encodes a novel nuclear protein with (S/T)PXX motifs that is expressed during development. (PMID: 15606750) Sugiura N. … Corriveau R.A. (Eur. J. Biochem. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for ICE2 Gene

Sources for ICE2 Gene

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