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Aliases for ICE2 Gene

Aliases for ICE2 Gene

  • Interactor Of Little Elongation Complex ELL Subunit 2 2 3
  • NARG2 3 4 6
  • Interactor Of Little Elongator Complex ELL Subunit 2 3 4
  • NMDA Receptor-Regulated Protein 2 3 4
  • NMDA Receptor Regulated 2 2 3
  • Breast Cancer Cell 1 2 3
  • BRCC1 3 4
  • Little Elongation Complex Subunit 2 3
  • NMDA Receptor-Regulated Gene 2 3

External Ids for ICE2 Gene

Previous HGNC Symbols for ICE2 Gene

  • NARG2

Summaries for ICE2 Gene

GeneCards Summary for ICE2 Gene

ICE2 (Interactor Of Little Elongation Complex ELL Subunit 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ICE2 Gene

  • Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICE2 Gene

Genomics for ICE2 Gene

Genomic Location for ICE2 Gene

Start:
60,419,609 bp from pter
End:
60,479,160 bp from pter
Size:
59,552 bases
Orientation:
Minus strand

Genomic View for ICE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ICE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICE2 Gene

No data available for Regulatory Elements for ICE2 Gene

Proteins for ICE2 Gene

  • Protein details for ICE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q659A1-ICE2_HUMAN
    Recommended name:
    Little elongation complex subunit 2
    Protein Accession:
    Q659A1
    Secondary Accessions:
    • B2RU08
    • Q05CT1
    • Q3B7W6
    • Q63HP4
    • Q658Q0
    • Q68CN8
    • Q6IPW7
    • Q6UX23
    • Q71H65
    • Q96CY5
    • Q9HAA2

    Protein attributes for ICE2 Gene

    Size:
    982 amino acids
    Molecular mass:
    110011 Da
    Quaternary structure:
    • Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2. Interacts with ICE1 (via C-terminus domain). Interacts with ELL.
    SequenceCaution:
    • Sequence=AAH13684.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH20918.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI07428.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAQ88910.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305}; Sequence=BAB13948.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH18700.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for ICE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ICE2 Gene

Proteomics data for ICE2 Gene at MOPED

Post-translational modifications for ICE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ICE2 Gene

Domains for ICE2 Gene

Protein Domains for ICE2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q659A1

UniProtKB/Swiss-Prot:

ICE2_HUMAN :
  • Q659A1
Family:
  • Belongs to the ICE2 family.
genes like me logo Genes that share domains with ICE2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for ICE2 Gene

Function for ICE2 Gene

Molecular function for ICE2 Gene

UniProtKB/Swiss-Prot Function: Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.

Gene Ontology (GO) - Molecular Function for ICE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22195968
genes like me logo Genes that share ontologies with ICE2: view

Phenotypes for ICE2 Gene

GenomeRNAi human phenotypes for ICE2:
genes like me logo Genes that share phenotypes with ICE2: view

miRNA for ICE2 Gene

miRTarBase miRNAs that target ICE2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ICE2 Gene

Localization for ICE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICE2 Gene

Nucleus. Note=Colocalizes with COIL in subnuclear Cajal and histone locus bodies. Translocates in the LEC complex to Cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.

Gene Ontology (GO) - Cellular Components for ICE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0008023 transcription elongation factor complex IMP 22195968
GO:0015030 Cajal body IDA 23932780
GO:0035327 transcriptionally active chromatin IDA 22195968
GO:0035363 histone locus body IDA 23932780
genes like me logo Genes that share ontologies with ICE2: view

No data available for Subcellular locations from COMPARTMENTS for ICE2 Gene

Pathways for ICE2 Gene

SuperPathways for ICE2 Gene

No Data Available

Interacting Proteins for ICE2 Gene

Gene Ontology (GO) - Biological Process for ICE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042795 snRNA transcription from RNA polymerase II promoter IMP 23932780
GO:0042796 snRNA transcription from RNA polymerase III promoter IMP 23932780
GO:0045945 positive regulation of transcription from RNA polymerase III promoter IMP 23932780
genes like me logo Genes that share ontologies with ICE2: view

No data available for Pathways by source for ICE2 Gene

Transcripts for ICE2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ICE2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: - - -
SP5:
SP6: -
SP7:

Relevant External Links for ICE2 Gene

GeneLoc Exon Structure for
ICE2
ECgene alternative splicing isoforms for
ICE2

Expression for ICE2 Gene

mRNA expression in normal human tissues for ICE2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ICE2 Gene

mRNA Expression by UniProt/SwissProt for ICE2 Gene

Q659A1-ICE2_HUMAN
Tissue specificity: Expressed at low levels in lung and testis.
genes like me logo Genes that share expressions with ICE2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ICE2 Gene

Orthologs for ICE2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ICE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NARG2 35
  • 99.25 (n)
  • 99.08 (a)
NARG2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NARG2 35
  • 89.88 (n)
  • 87.93 (a)
NARG2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NARG2 35
  • 91.24 (n)
  • 89.06 (a)
NARG2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Narg2 35
  • 82.13 (n)
  • 78.74 (a)
Narg2 16
Narg2 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NARG2 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NARG2 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Narg2 35
  • 82.98 (n)
  • 80.13 (a)
chicken
(Gallus gallus)
Aves NARG2 35
  • 61.3 (n)
  • 49.89 (a)
NARG2 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NARG2 36
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia narg2 35
  • 52.93 (n)
  • 45.66 (a)
zebrafish
(Danio rerio)
Actinopterygii narg2 35
  • 46.56 (n)
  • 40.21 (a)
narg2 36
  • 30 (a)
OneToOne
Species with no ortholog for ICE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ICE2 Gene

ENSEMBL:
Gene Tree for ICE2 (if available)
TreeFam:
Gene Tree for ICE2 (if available)

Paralogs for ICE2 Gene

Pseudogenes.org Pseudogenes for ICE2 Gene

genes like me logo Genes that share paralogs with ICE2: view

No data available for Paralogs for ICE2 Gene

Variants for ICE2 Gene

Sequence variations from dbSNP and Humsavar for ICE2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs3068 -- 60,423,444(-) CCCTT(A/G)AAGTT utr-variant-3-prime
rs936013 -- 60,426,066(-) GCATT(C/G)AGTCC intron-variant
rs1046657 -- 60,423,601(-) AAAAA(A/C)CAGTT utr-variant-3-prime
rs1057525 -- 60,431,481(-) TCCTC(A/C)ATTCT intron-variant
rs1063100 -- 60,442,498(-) TGTTA(C/T)GGAGT synonymous-codon, reference

Relevant External Links for ICE2 Gene

HapMap Linkage Disequilibrium report
ICE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ICE2 Gene

Disorders for ICE2 Gene

No disorders were found for ICE2 Gene.

No data available for UniProtKB/Swiss-Prot for ICE2 Gene

Publications for ICE2 Gene

  1. The little elongation complex functions at initiation and elongation phases of snRNA gene transcription. (PMID: 23932780) Hu D. … Shilatifard A. (Mol. Cell 2013) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The little elongation complex regulates small nuclear RNA transcription. (PMID: 22195968) Smith E.R. … Shilatifard A. (Mol. Cell 2011) 3 4
  5. N-methyl-D-aspartate receptors regulate a group of transiently expressed genes in the developing brain. (PMID: 11297529) Sugiura N. … Corriveau R.A. (J. Biol. Chem. 2001) 2 3

Products for ICE2 Gene

Sources for ICE2 Gene

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