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Aliases for ICAM5 Gene

Aliases for ICAM5 Gene

  • Intercellular Adhesion Molecule 5 2 3 5
  • Telencephalin 2 3 4
  • ICAM-5 3 4
  • TLCN 3 4
  • TLN 3 4
  • Intercellular Adhesion Molecule 5, Telencephalin 3

External Ids for ICAM5 Gene

Previous HGNC Symbols for ICAM5 Gene

  • TLCN

Previous GeneCards Identifiers for ICAM5 Gene

  • GC19P010522
  • GC19P010623
  • GC19P010246
  • GC19P010261
  • GC19P010400
  • GC19P009980

Summaries for ICAM5 Gene

Entrez Gene Summary for ICAM5 Gene

  • The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008]

GeneCards Summary for ICAM5 Gene

ICAM5 (Intercellular Adhesion Molecule 5) is a Protein Coding gene. Among its related pathways are Immune System and ECM-receptor interaction. GO annotations related to this gene include integrin binding. An important paralog of this gene is ICAM1.

UniProtKB/Swiss-Prot for ICAM5 Gene

  • ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).

Gene Wiki entry for ICAM5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICAM5 Gene

Genomics for ICAM5 Gene

Regulatory Elements for ICAM5 Gene

Enhancers for ICAM5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ICAM5 on UCSC Golden Path with GeneCards custom track

Promoters for ICAM5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ICAM5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ICAM5 Gene

10,289,435 bp from pter
10,296,778 bp from pter
7,344 bases
Plus strand

Genomic View for ICAM5 Gene

Genes around ICAM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICAM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICAM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICAM5 Gene

Proteins for ICAM5 Gene

  • Protein details for ICAM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Intercellular adhesion molecule 5
    Protein Accession:
    Secondary Accessions:
    • Q9Y6F3

    Protein attributes for ICAM5 Gene

    924 amino acids
    Molecular mass:
    97116 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ICAM5 Gene

neXtProt entry for ICAM5 Gene

Proteomics data for ICAM5 Gene at MOPED

Post-translational modifications for ICAM5 Gene

  • Glycosylation at Asn-54 is critical for functional folding.
  • Glycosylation at Asn 54, Asn 74, Asn 137, Asn 195, Asn 214, Asn 303, Asn 316, Asn 371, Asn 397, Asn 583, Asn 646, Asn 764, Asn 795, and Asn 796
  • Modification sites at PhosphoSitePlus

Other Protein References for ICAM5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ICAM5

No data available for DME Specific Peptides for ICAM5 Gene

Domains & Families for ICAM5 Gene

Gene Families for ICAM5 Gene

Suggested Antigen Peptide Sequences for ICAM5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 9 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. ICAM family.
  • Contains 9 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. ICAM family.
genes like me logo Genes that share domains with ICAM5: view

Function for ICAM5 Gene

Molecular function for ICAM5 Gene

GENATLAS Biochemistry:
intercellular adhesion molecule 5,telencephalin,ligand for LFA1,brain segment specific neuronal adhesion molecule,Ig superfamily,highly homolog to ICAM1,ICAM3,expressed in cell body and dendrites of neurons in the telencephalin from birth and throughout life
UniProtKB/Swiss-Prot Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).
genes like me logo Genes that share phenotypes with ICAM5: view

Animal Model Products

miRNA for ICAM5 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ICAM5 Gene

Localization for ICAM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICAM5 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for ICAM5 Gene COMPARTMENTS Subcellular localization image for ICAM5 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytosol 1
endosome 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for ICAM5 Gene

Pathways & Interactions for ICAM5 Gene

genes like me logo Genes that share pathways with ICAM5: view

Gene Ontology (GO) - Biological Process for ICAM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006909 phagocytosis IEA --
GO:0016337 single organismal cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with ICAM5: view

No data available for SIGNOR curated interactions for ICAM5 Gene

Drugs & Compounds for ICAM5 Gene

No Compound Related Data Available

Transcripts for ICAM5 Gene

Unigene Clusters for ICAM5 Gene

Intercellular adhesion molecule 5, telencephalin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ICAM5 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: - -

Relevant External Links for ICAM5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ICAM5 Gene

mRNA expression in normal human tissues for ICAM5 Gene

mRNA differential expression in normal tissues according to GTEx for ICAM5 Gene

This gene is overexpressed in Brain - Hippocampus (x6.8), Brain - Nucleus accumbens (basal ganglia) (x6.6), Brain - Cortex (x6.5), Brain - Anterior cingulate cortex (BA24) (x5.7), Brain - Frontal Cortex (BA9) (x5.5), and Brain - Putamen (basal ganglia) (x4.3).

Protein differential expression in normal tissues from HIPED for ICAM5 Gene

This gene is overexpressed in Brain (39.9) and Frontal cortex (25.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ICAM5 Gene

SOURCE GeneReport for Unigene cluster for ICAM5 Gene Hs.465862

mRNA Expression by UniProt/SwissProt for ICAM5 Gene

Tissue specificity: Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon.
genes like me logo Genes that share expression patterns with ICAM5: view

Protein tissue co-expression partners for ICAM5 Gene

Primer Products

Orthologs for ICAM5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ICAM5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ICAM5 35
  • 86.91 (n)
  • 88.83 (a)
ICAM5 36
  • 88 (a)
(Canis familiaris)
Mammalia ICAM5 35
  • 87.2 (n)
  • 89.26 (a)
ICAM5 36
  • 89 (a)
(Mus musculus)
Mammalia Icam5 35
  • 82.08 (n)
  • 84.62 (a)
Icam5 16
Icam5 36
  • 85 (a)
(Pan troglodytes)
Mammalia ICAM5 35
  • 94.63 (n)
  • 93.71 (a)
ICAM5 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Icam5 35
  • 81.79 (n)
  • 85.28 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 22 (a)
-- 36
  • 29 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia icam5 35
  • 45.4 (n)
  • 36.21 (a)
Species with no ortholog for ICAM5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ICAM5 Gene

Gene Tree for ICAM5 (if available)
Gene Tree for ICAM5 (if available)

Paralogs for ICAM5 Gene

Paralogs for ICAM5 Gene

(4) SIMAP similar genes for ICAM5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ICAM5: view

Variants for ICAM5 Gene

Sequence variations from dbSNP and Humsavar for ICAM5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_035515 A breast cancer sample
VAR_035516 A breast cancer sample
VAR_035517 A breast cancer sample
rs1056538 - 10,292,262(-) GCAGA(C/T)CAGCT reference, missense
rs2228615 - 10,292,692(+) CTGGG(A/G)CCCAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ICAM5 Gene

Variant ID Type Subtype PubMed ID
nsv911029 CNV Loss 21882294
nsv911030 CNV Loss 21882294
dgv3725n71 CNV Loss 21882294
nsv911033 CNV Gain 21882294
dgv3726n71 CNV Loss 21882294
nsv911037 CNV Gain 21882294
nsv470124 CNV Gain 18288195

Variation tolerance for ICAM5 Gene

Residual Variation Intolerance Score: 15.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.33; 96.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ICAM5 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICAM5 Gene

Disorders for ICAM5 Gene

Relevant External Links for ICAM5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ICAM5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ICAM5 Gene

Publications for ICAM5 Gene

  1. cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1. (PMID: 8995416) Mizuno T. … Mori K. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2. (PMID: 9828136) Kilgannon P. … Gallatin W.M. (Genomics 1998) 2 3 23
  3. Shedded neuronal ICAM-5 suppresses T-cell activation. (PMID: 18223167) Tian L. … Gahmberg C.G. (Blood 2008) 3 23
  4. Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins. (PMID: 11719200) Annaert W.G. … De Strooper B. (Neuron 2001) 3 23
  5. Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction with the leukocyte integrin CD11a/CD18. (PMID: 10741396) Tian L. … Gahmberg C.G. (Eur. J. Immunol. 2000) 3 23

Products for ICAM5 Gene

Sources for ICAM5 Gene