ICAM5 Gene

Aliases
for ICAM5 gene

Previous GC identifers: GC19P010522 GC19P010623 GC19P010246 GC19P010261 GC19P009980

Summaries
for ICAM5 gene

Genomic Views
for ICAM5 gene

RefSeq DNA sequence:

NC_000019.9  NC_018930.1  NT_011295.11  

SwitchGear Promoter luciferase reporter plasmid: ICAM5 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ICAM5

ICAM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P010400:  view genomic region     (about GC identifiers)

Proteins
for ICAM5 gene

1 PDB 3D structure from and Proteopedia for ICAM5:

3BN3 (3D)    

Explore the universe of human proteins at neXtProt for ICAM5: NX_Q9UMF0

Post-translational modifications:

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	R&D Systems Recombinant & Natural Proteins for ICAM5 (ICAM-5)
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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for ICAM5
	GenScript Custom Purified and Recombinant Proteins Services for ICAM5
	Novus Biologicals ICAM5 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ICAM5

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

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	R&D Systems Antibodies for ICAM5 (ICAM-5)
	OriGene Antibodies: ICAM5 OriGene Custom Antibody Services for ICAM5
	GenScript Custom Superior Antibodies Services for ICAM5
	Novus Biologicals ICAM5 Antibodies
	Search for Antibodies for ICAM5 at Abcam
	Uscn Antibodies for ICAM5
	ThermoFisher Antibodies for ICAM5

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ICAM5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ICAM5

Protein Domains /
Families
for ICAM5 gene

ProtoNet protein and cluster: Q9UMF0

Function
for ICAM5 gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ICAM5
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate ICAM5:
		hsa-miR-3163 hsa-miR-548am hsa-miR-3132 hsa-miR-548x hsa-miR-340
		SwitchGear 3'UTR luciferase reporter plasmid: ICAM5 3' UTR sequence

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ICAM5 (see all 4) OriGene shRNA RFP: ICAM5 OriGene siRNA: ICAM5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ICAM5

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for ICAM5

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ICAM5 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ICAM5 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ICAM5 (NM_003259)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICAM5

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM5

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

(inferred from 1 allele) (MGI details for Icam5)

Pathways & Interactions
for ICAM5 gene

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for ICAM5 gene

Transcripts
for ICAM5 gene

Expression
for ICAM5 gene

ICAM5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAAGCCACG

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ICAM5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ICAM5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ICAM5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ICAM5

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM5

Orthologs
for ICAM5 gene

Paralogs
for ICAM5 gene

Paralogs for ICAM5 gene

ICAM4²  ICAM2²  ICAM1²  ICAM3²  

4 SIMAP similar genes for ICAM5 using alignment to 4 protein entries:     ICAM5_HUMAN (see all proteins):

ICAM3    P3.58    ICAM1    ICAM-1

ICAM5 for paralogs           About GeneDecksing

Genomic Variants
for ICAM5 gene

10/155 NCBI SNPs in ICAM5 are shown (see all 155)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1836884561,2		--	10399770(+)	GAATTC/TTGACG	1	--	us2k1		0	--	--	--	--
rs346695511,2	C,	--	10399785(+)	TCTGGT/CAGTCA	1	--	us2k1		4		NS NA	98
rs779230451,2	F,	--	10399823(+)	GGGTGG/AGGGGT	1	--	us2k1		1		EA	120
rs1894302861,2		--	10399889(+)	CTCGCA/GTGGAT	1	--	us2k1		0	--	--	--	--
rs25696931,2	C,F,H,	--	10399904(+)	GGGCCC/TCCACC	1	--	us2k1		20		NA EA NS WA	3392
rs1815259271,2		--	10399955(+)	TCGAGC/GTCACA	1	--	us2k1		0	--	--	--	--
rs1163812631,2	F,	--	10399988(+)	GCTGCA/CCCCTG	1	--	us2k1		1		WA	118
rs350993611,2	C,F,	--	10400025(+)	GATTCT/CAATTT	1	--	us2k1		5		NS NA WA	216
rs2814391,2	C,F,H,	--	10400110(+)	CGTGCC/GGGAGC	1	--	us2k1		16		MN NS EA NA WA CSA	1065
rs2814401,2	C,F,A,H,	--	10400304(+)	GGCGGA/GGCTCG	1	--	us2k1		36		EA NA MN NS WA CSA	4345

HapMap Linkage Disequilibrium report for ICAM5 (10400655 - 10407454 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ICAM5
     1 CNV: 29685
Human Gene Mutation Database (HGMD): ICAM5

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ICAM5

DNA2.0 Custom Variant and Variant Library Synthesis for ICAM5

Disorders / Diseases
for ICAM5 gene

18 diseases for ICAM5

1 Novoseek disease relationship for ICAM5 gene    About this table

Publications
for ICAM5 gene

PubMed articles for ICAM5 gene, integrated from 9 sources (see all 55) (see top 10): (articles sorted by number of sources associating them with ICAM5)

Utopia: connect your pdf to the dynamic world of online information

1. cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1. (PubMed id 8995416)^{1, 2, 3, 9} Mizuno T.... Mori K. (1997)
2. Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2. (PubMed id 9828136)^{1, 2, 3, 9} Kilgannon P.... Gallatin W.M. (1998)
3. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)^{1, 2} Brill L.M....Peters E.C. (2004)
4. Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction with the leukocyte integrin CD11a/CD18. (PubMed id 10741396)^{1, 9} Tian L....Gahmberg C.G. (2000)
5. Neuronal adhesion molecule telencephalin induces rapid cell spreading of microglia. (PubMed id 10592287)^{1, 9} Mizuno T....Mori K. (1999)
6. Development of telencephalin in the human cerebrum. (PubMed id 10402269)^{1, 9} Arii N....Takashima S. (1999)
7. Telencephalin: a neuronal area code molecule? (PubMed id 7724062)^{1, 9} Yoshihara Y. and Mori K. (1994)
8. Shedded neuronal ICAM-5 suppresses T-cell activation. (PubMed id 18223167)^{1, 9} Tian L....Gahmberg C.G. (2008)
9. Polarized distribution and cell type-specific localization of telencephalin, an intercellular adhesion molecule. (PubMed id 9556028)^{1, 9} Benson D.L....Mori K. (1998)
10. Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins. (PubMed id 11719200)^{1, 9} Annaert W.G....De Strooper B. (2001)
11. Telencephalin as an indicator for temporal-lobe dysfunction. (PubMed id 9717930)^{1, 9} Rieckmann P....Steinhoff B.J. (1998)
12. ARF6-mediated endosomal transport of Telencephalin aff ects dendritic filopodia-to-spine maturation. (PubMed id 22781129)¹ Raemaekers T....Annaert W. (2012)
13. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)¹ Rajaraman P....Inskip P.D. (2010)
14. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (2010)
15. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)¹ Han S....Kang D. (2010)
16. Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)¹ Mosbruger T.L....Thio C.L. (2010)
17. A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiat ion in rectal cancer. (PubMed id 20644561)¹ Ho-Pun-Cheung A....Lopez-Crapez E. (2010)
18. Common single nucleotide polymorphisms in immunoregul atory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)¹ Lee K.M....Lan Q. (2010)
19. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
20. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)¹ Hosgood H.D....Lan Q. (2009)
21. Common variation in genes related to innate immunity and risk of adult glioma. (PubMed id 19423540)¹ Rajaraman P....Chanock S.J. (2009)
22. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)¹ Mavaddat N....Pharoah P.D. (2009)
23. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
24. An unusual allosteric mobility of the C-terminal helix of a high- affinity alphaL integrin I domain variant bound to ICAM-5. (PubMed id 18691975)² Zhang H.... Wang J.H. (2008)
25. A common coding variant in CASP8 is associated with breast cancer risk. (PubMed id 17293864)¹ Cox A....Easton D.F. (2007)
26. Polymorphisms in the ICAM gene locus are not associated with breast cancer Risk. (PubMed id 16434609)¹ Cox D.G....Hunter D.J. (2006)
27. alpha-Actinin-dependent cytoskeletal anchorage is important for ICAM-5-mediated neuritic outgrowth. (PubMed id 16820411)¹ Nyman-Huttunen H....Gahmberg C.G. (2006)
28. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)² Sjoeblom T.... Velculescu V.E. (2006)
29. ICAM gene cluster SNPs and prostate cancer risk in African Americans. (PubMed id 16733712)¹ Chen H....Kittles R.A. (2006)
30. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (2004)
31. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)¹ Gevaert K.... Vandekerckhove J. (2003)
32. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
33. Intercellular adhesion molecule-5 induces dendritic outgrowth by homophilic adhesion. (PubMed id 10893271)¹ Tian L....Gahmberg C.G. (2000)
34. The intercellular adhesion molecule (ICAM) family of proteins. New members and novel functions. (PubMed id 9638475)¹ Hayflick J.S....Gallatin W.M. (1998)
35. ICAM-5 (telencephalin) gene expression in head and neck squamous carcinoma tumorigenesis and perineural invasion! (PubMed id 15975520)⁹ Maruya S.I....El-Naggar A.K. (2005)
36. Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. (PubMed id 15452145)⁹ Esselens C....Annaert W. (2004)
37. A transcriptional enhancer that directs telencephalon-specific transgene expression in mouse brain. (PubMed id 16581979)⁹ Mitsui S....Yoshihara Y. (2007)
38. Structural study of the N-glycans of intercellular ad hesion molecule-5 (telencephalin). (PubMed id 19733219)⁹ Ohgomori T....Ikekita M. (2009)
39. Interaction between telencephalin and ERM family proteins mediates dendritic filopodia formation. (PubMed id 17699668)⁹ Furutani Y....Yoshihara Y. (2007)
40. Ectopic expression of telencephalin in brains with holoprosencephaly. (PubMed id 11045672)⁹ Arii N....Takashima S. (2000)
41. Cognitive fMRI and soluble telencephalin assessment in patients with localization-related epilepsy. (PubMed id 18460045)⁹ Jansen J.F....Aldenkamp A.P. (2008)
42. The neuronal glycoprotein telencephalin is a cellular ligand for the CD11a/CD18 leukocyte integrin. (PubMed id 8993013)⁹ Tian L....Gahmberg C.G. (1997)
43. Involvement of dendritic adhesion molecule telencephalin in hippocampal long-term potentiation. (PubMed id 9579684)⁹ Sakurai E....Mori K. (1998)
44. Reduction of telencephalin immunoreactivity in the brain of patients with Alzheimer's disease. (PubMed id 9125424)⁹ Hino H....Kosaka K. (1997)
45. Appearance of LFA-1 in the initial stage of synaptogenesis of developing hippocampal neurons. (PubMed id 18622091)⁹ Wakabayashi Y....Kawata M. (2008)
46. Soluble Telencephalin in the serum of children after febrile seizures. (PubMed id 15726263)⁹ Borusiak P....Rieckmann P. (2005)
47. Release of soluble ICAM-5, a neuronal adhesion molecule, in acute encephalitis. (PubMed id 11839847)⁹ Lindsberg P.J....Gahmberg C.G. (2002)
48. [Telencephalin, a dendrite-associated cell adhesion molecule with brain segment-specific expression] (PubMed id 9162997)⁹ Mori K. and Yoshihara Y. (1997)
49. [Telencephalon-specific cell adhesion molecule, telen cephalin] (PubMed id 8787047)⁹ Yoshihara Y....Tamada A. (1996)
50. [AxCAMs and DenCAMs: a novel classification of neuronal cell recognition/adhesion molecules--with special reference to a telencephalon-specific glycoprotein, telencephalin] (PubMed id 7886240)⁹ Yoshihara Y. and Mori K. (1995)
51. Dendritic spine formation and stabilization. (PubMed id 19523814)⁹ Yoshihara Y....Muller D. (2009)
52. ICAM-5--a novel two-facetted adhesion molecule in the mammalian brain. (PubMed id 18367254)⁹ Gahmberg C.G....Nyman-Huttunen H. (2008)
53. Presenilin 1: more than just gamma-secretase. (PubMed id 16042544)⁹ Raemaekers T....Annaert W. (2005)

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