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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ICAM5 Gene

protein-coding   GIFtS: 59
GCID: GC19P010400

Intercellular Adhesion Molecule 5, Telencephalin


(Previous symbol: TLCN)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Intercellular Adhesion Molecule 5, Telencephalin1 2     ICAM-52 3
TLCN1 2 3 5     Intercellular Adhesion Molecule 52
TLN2 3 5     Telencephalin3
telencephalin1 2     

External Ids:    HGNC: 53481   Entrez Gene: 70872   Ensembl: ENSG000001053767   OMIM: 6018525   UniProtKB: Q9UMF03   

Export aliases for ICAM5 gene to outside databases

Previous GC identifers: GC19P010522 GC19P010623 GC19P010246 GC19P010261 GC19P009980


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ICAM5 Gene:
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM
proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the
leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays
two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and
leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal
development or as part of neurodegenerative diseases. (provided by RefSeq, Jul 2008)

GeneCards Summary for ICAM5 Gene: 
ICAM5 (intercellular adhesion molecule 5, telencephalin) is a protein-coding gene. Diseases associated with ICAM5 include febrile seizures, and holoprosencephaly. GO annotations related to this gene include protein binding. An important paralog of this gene is ICAM4.

UniProtKB/Swiss-Prot: ICAM5_HUMAN, Q9UMF0
Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2)

Gene Wiki entry for ICAM5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ICAM5 gene promoter:
         GR   STAT1   AP-2alpha isoform 3   STAT1beta   AP-2alpha isoform 2   STAT1alpha   AP-2alpha isoform 4   GR-alpha   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidICAM5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ICAM5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ICAM5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ICAM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ICAM5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P010400:  view genomic region     (about GC identifiers)

Start:
10,400,655 bp from pter      End:
10,407,454 bp from pter
Size:
6,800 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ICAM5_HUMAN, Q9UMF0 (See protein sequence)
Recommended Name: Intercellular adhesion molecule 5 precursor  
Size: 924 amino acids; 97116 Da
Subcellular location: Membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for ICAM5:
3BN3 (3D)    
Secondary accessions: Q9Y6F3

Explore the universe of human proteins at neXtProt for ICAM5: NX_Q9UMF0

Explore proteomics data for ICAM5 at MOPED 

Post-translational modifications:

  • UniProtKB: Glycosylation at Asn-54 is critical for functional folding (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UMF0

  • ICAM5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ICAM5 Protein Expression
    REFSEQ proteins: NP_003250.3  
    ENSEMBL proteins: 
     ENSP00000221980   ENSP00000464796  

    Human Recombinant Protein Products for ICAM5: 
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    Novus Biologicals ICAM5 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ICAM5 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS8995416
    GO:0005887integral to plasma membrane TAS8995416

    ICAM5 for ontologies           About GeneDecksing



    ICAM5 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for ICAM5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    5/7 InterPro protein domains (see all 7):
     IPR003598 Ig_sub2
     IPR003988 ICAM
     IPR013768 ICAM_N
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UMF0

    ProtoNet protein and cluster: Q9UMF0

    5 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB003987 Intercellular adhesion molecule/vascular cell adhesion molecule-1 signature
    IPB003988 Intercellular adhesion molecule (ICAM) family signature
    IPB013098 Immunoglobulin I-set
    IPB013768 Intercellular adhesion molecule


    UniProtKB/Swiss-Prot: ICAM5_HUMAN, Q9UMF0
    Similarity: Belongs to the immunoglobulin superfamily. ICAM family
    Similarity: Contains 9 Ig-like C2-type (immunoglobulin-like) domains


    ICAM5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ICAM5_HUMAN, Q9UMF0
    Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2)

         Genatlas biochemistry entry for ICAM5:
    intercellular adhesion molecule 5,telencephalin,ligand for LFA1,brain segment specific neuronal adhesion
    molecule,Ig superfamily,highly homolog to ICAM1,ICAM3,expressed in cell body and dendrites of neurons in the
    telencephalin from birth and throughout life

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16820411
         
    ICAM5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ICAM5:
     Increased circadian period len 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Icam5):
     behavior/neurological  nervous system 

    ICAM5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ICAM5 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ICAM5 
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    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate ICAM5:
    hsa-miR-3163 hsa-miR-548am hsa-miR-3132 hsa-miR-548x hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidICAM5 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ICAM5

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for ICAM5 (Q9UMF01, 3 ENSP000002219804) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSEN1P497683, ENSP000003263664I2D: score=3 STRING: ENSP00000326366
    CSF1P096033, ENSP000003275134I2D: score=1 STRING: ENSP00000327513
    ITGB2P051073, ENSP000003032424I2D: score=1 STRING: ENSP00000303242
    ITGALP207013, ENSP000003492524I2D: score=1 STRING: ENSP00000349252
    PSEN2P498103, ENSP000003557474I2D: score=3 STRING: ENSP00000355747
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006909phagocytosis IEA--
    GO:0016337cell-cell adhesion IEA--

    ICAM5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ICAM5

    Search CenterWatch for drugs/clinical trials and news about ICAM5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ICAM5 gene: 
    NM_003259.3  

    Unigene Cluster for ICAM5:

    Intercellular adhesion molecule 5, telencephalin
    Hs.465862  [show with all ESTs]
    Unigene Representative Sequence: BC026338
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000221980(uc002mnu.4 uc002mnv.4) ENST00000588912 ENST00000586004
    ENST00000587398 ENST00000586480

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate ICAM5:
    hsa-miR-3163 hsa-miR-548am hsa-miR-3132 hsa-miR-548x hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidICAM5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ICAM5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ICAM5
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ICAM5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICAM5
    Sirion Biotech Customized lentivirus for stable overexpression of ICAM5 
                         Customized lentivirus expression plasmids for stable overexpression of ICAM5 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ICAM5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ICAM5

    Additional mRNA sequence: 

    AK295887.1 BC026338.1 BC030132.2 U72671.1 

    2 DOTS entries:

    DT.209677  DT.97805583 

    24/33 AceView cDNA sequences (see all 33):

    AI769028 BF732427 AI568610 AI085324 BV188540 BC030132 BX106276 AI199660 
    BM544595 BF527698 AW276559 BV183832 NM_003259 BM921826 BV174838 BU689127 
    U72671 BC026338 BE163470 AI811252 BG701036 R61108 BM805464 AI968424 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ICAM5    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:              -                                                                                 
    SP2:              -           -                                                                     
    SP3:                                                                                                


    ECgene alternative splicing isoforms for ICAM5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ICAM5 expression in normal human tissues (normalized intensities)      ICAM5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAGCCACG
    ICAM5 Expression
    About this image


    ICAM5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 23 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   

    See ICAM5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ICAM5

    SOURCE GeneReport for Unigene cluster: Hs.465862

    UniProtKB/Swiss-Prot: ICAM5_HUMAN, Q9UMF0
    Tissue specificity: Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ICAM5 gene from 6 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia ICAM56
    intercellular adhesion molecule 5, telencephalin
    99(a)
    1 ↔ 1
    19(10479636-10487882)
    mouse
    (Mus musculus)
    Mammalia Icam51 , 5 intercellular adhesion molecule 5, telencephalin1, 5 82.59(n)1
    85.5(a)1
      9 (7.70 cM)5
    158981  NM_008319.21  NP_032345.21 
     210320385 
    rat
    (Rattus norvegicus)
    Mammalia Icam51 intercellular adhesion molecule 5, telencephalin 82.3(n)
    86.15(a)
      313785  XM_233737.5  XP_233737.5 
    cow
    (Bos taurus)
    Mammalia ICAM51 intercellular adhesion molecule 5, telencephalin 86.91(n)
    88.83(a)
      505158  NM_001113762.1  NP_001107234.1 
    dog
    (Canis familiaris)
    Mammalia ICAM51 intercellular adhesion molecule 5, telencephalin 87.2(n)
    89.26(a)
      484958  XM_542074.2  XP_542074.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    28(a)
    25(a)
    1 ↔ many
    possible ortholog
    GL344305.1(30522-49910)
    GL343233.1(1353200-1357090)
            Species with no ortholog for ICAM5

    ENSEMBL Gene Tree for ICAM5 (if available)
    TreeFam Gene Tree for ICAM5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ICAM5 gene
    ICAM42  ICAM22  ICAM12  ICAM32  
    4 SIMAP similar genes for ICAM5 using alignment to 4 protein entries:     ICAM5_HUMAN (see all proteins):
    ICAM3    P3.58    ICAM1    ICAM-1

    ICAM5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/219 SNPs in ICAM5 are shown (see all 219)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355154
    A breast cancer sample4--see VAR_0355152 L V mis40--------
    VAR_0355174
    A breast cancer sample4--see VAR_0355172 E Q mis40--------
    VAR_0355164
    A breast cancer sample4--see VAR_0355162 R W mis40--------
    rs1836884561,2
    --10399770(+) GAATTC/TTGACG 1 -- us2k10--------
    rs346695511,2
    C--10399785(+) TCTGGT/CAGTCA 1 -- us2k14Minor allele frequency- C:0.01NS NA 98
    rs779230451,2
    F--10399823(+) GGGTGG/AGGGGT 1 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1894302861,2
    --10399889(+) CTCGCA/GTGGAT 1 -- us2k10--------
    rs25696931,2
    C,F,H--10399904(+) GGGCCC/TCCACC 1 -- us2k120Minor allele frequency- T:0.27NA EA NS WA 3392
    rs1815259271,2
    --10399955(+) TCGAGC/GTCACA 1 -- us2k10--------
    rs1163812631,2
    C,F--10399988(+) GCTGCA/CCCCTG 1 -- us2k11Minor allele frequency- C:0.05WA 118

    HapMap Linkage Disequilibrium report for ICAM5 (10400655 - 10407454 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ICAM5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911030CNV Loss21882294
    nsv911029CNV Loss21882294
    dgv3726n71CNV Loss21882294
    dgv3725n71CNV Loss21882294
    nsv911033CNV Gain21882294
    nsv470124CNV Gain18288195
    nsv911037CNV Gain21882294


    Human Gene Mutation Database (HGMD): ICAM5
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601852    OMIM disorders: --

    15 diseases for ICAM5:    About MalaCards
    febrile seizures    holoprosencephaly    multiple myeloma    neuronitis
    alzheimer's disease    meningioma    encephalitis    myeloma
    hepatitis c    hepatitis b    hepatitis    prostate cancer
    prostatitis    breast cancer    leukemia


    ICAM5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for ICAM5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 11.4 2 9125424 (2)

    Genetic Association Database (GAD): ICAM5
    Human Genome Epidemiology (HuGE) Navigator: ICAM5 (16 documents)

    Export disorders for ICAM5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ICAM5 gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with ICAM5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1. (PubMed id 8995416)1, 2, 3, 9 Mizuno T.... Mori K. (1997)
    2. Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2. (PubMed id 9828136)1, 2, 3, 9 Kilgannon P.... Gallatin W.M. (1998)
    3. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    4. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    5. Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (2010)
    6. Common single nucleotide polymorphisms in immunoregul atory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    9. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (2009)
    10. A common coding variant in CASP8 is associated with breast cancer risk. (PubMed id 17293864)1, 4 Cox A....Easton D.F. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7087 HGNC: 5348 AceView: ICAM5 Ensembl:ENSG00000105376 euGenes: HUgn7087
    ECgene: ICAM5 H-InvDB: ICAM5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ICAM5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ICAM5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ICAM5 gene:
    Search GeneIP for patents involving ICAM5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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