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Aliases for ICAM5 Gene

Aliases for ICAM5 Gene

  • Intercellular Adhesion Molecule 5 2 3 5
  • Telencephalin 2 3 4
  • ICAM-5 3 4
  • TLCN 3 4
  • TLN 3 4
  • Intercellular Adhesion Molecule 5, Telencephalin 3

External Ids for ICAM5 Gene

Previous HGNC Symbols for ICAM5 Gene

  • TLCN

Previous GeneCards Identifiers for ICAM5 Gene

  • GC19P010522
  • GC19P010623
  • GC19P010246
  • GC19P010261
  • GC19P010400
  • GC19P009980

Summaries for ICAM5 Gene

Entrez Gene Summary for ICAM5 Gene

  • The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008]

GeneCards Summary for ICAM5 Gene

ICAM5 (Intercellular Adhesion Molecule 5) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and ECM-receptor interaction. GO annotations related to this gene include integrin binding. An important paralog of this gene is ICAM3.

UniProtKB/Swiss-Prot for ICAM5 Gene

  • ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).

Gene Wiki entry for ICAM5 Gene

Additional gene information for ICAM5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICAM5 Gene

Genomics for ICAM5 Gene

Regulatory Elements for ICAM5 Gene

Enhancers for ICAM5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H010400 1.5 FANTOM5 ENCODE 12.4 +114.8 114783 6.5 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 SP3 ICAM1 KANK2 MRPL4 ICAM5 ICAM4 RAVER1 PDE4A TYK2 C19orf38 P2RY11
GH19H010285 1.6 Ensembl ENCODE dbSUPER 11.5 +0.3 257 7.6 HNRNPUL1 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF143 ILF3 ZNF266 ZNF699 KRI1 ZNF559 LOC100419831 FBXL12 RAVER1 ZNF561 EIF3G
GH19H010250 1.1 Ensembl ENCODE 12 -39.2 -39235 0.4 HDAC1 RB1 ARNT ARID4B SIN3A KLF17 ZNF2 RAD21 ZNF121 ZNF143 ICAM5 ICAM4 EIF3G TYK2 C19orf66 MRPL4 S1PR2
GH19H010338 1 Ensembl ENCODE 12.6 +49.9 49909 2.3 BCOR HDGF TBL1XR1 MAX BACH1 SIN3A ZNF384 EBF1 RELA YY1 ICAM3 ENSG00000167807 ZGLP1 TYK2 ICAM5 ICAM4 ICAM1 MRPL4 PIR48013
GH19H010388 0.9 ENCODE 13 +99.6 99625 0.2 PKNOX1 ARID4B RAD21 ZNF143 ZNF207 IKZF2 DEK PAF1 SMARCA5 ZNF654 ZGLP1 ICAM5 ICAM1 MRPL4 ICAM4 EIF3G GC19P010382 MIR1181
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ICAM5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ICAM5 Gene

Genomic Locations for ICAM5 Gene
7,344 bases
Plus strand

Genomic View for ICAM5 Gene

Genes around ICAM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICAM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICAM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICAM5 Gene

Proteins for ICAM5 Gene

  • Protein details for ICAM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Intercellular adhesion molecule 5
    Protein Accession:
    Secondary Accessions:
    • Q9Y6F3

    Protein attributes for ICAM5 Gene

    924 amino acids
    Molecular mass:
    97116 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ICAM5 Gene

neXtProt entry for ICAM5 Gene

Post-translational modifications for ICAM5 Gene

  • Glycosylation at Asn-54 is critical for functional folding.
  • Glycosylation at posLast=5454, posLast=7474, isoforms=137, posLast=195195, isoforms=214, isoforms=303, posLast=316316, posLast=371371, isoforms=397, isoforms=583, posLast=646646, posLast=764764, isoforms=795, and isoforms=796
  • Modification sites at PhosphoSitePlus

Other Protein References for ICAM5 Gene

No data available for DME Specific Peptides for ICAM5 Gene

Domains & Families for ICAM5 Gene

Gene Families for ICAM5 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ICAM5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. ICAM family.
  • Belongs to the immunoglobulin superfamily. ICAM family.
genes like me logo Genes that share domains with ICAM5: view

Function for ICAM5 Gene

Molecular function for ICAM5 Gene

GENATLAS Biochemistry:
intercellular adhesion molecule 5,telencephalin,ligand for LFA1,brain segment specific neuronal adhesion molecule,Ig superfamily,highly homolog to ICAM1,ICAM3,expressed in cell body and dendrites of neurons in the telencephalin from birth and throughout life
UniProtKB/Swiss-Prot Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).

Phenotypes From GWAS Catalog for ICAM5 Gene

Gene Ontology (GO) - Molecular Function for ICAM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IBA --
GO:0005515 protein binding IPI 16820411
genes like me logo Genes that share ontologies with ICAM5: view
genes like me logo Genes that share phenotypes with ICAM5: view

miRNA for ICAM5 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ICAM5 Gene

Localization for ICAM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICAM5 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ICAM5 gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
mitochondrion 1
peroxisome 1
cytosol 1
lysosome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ICAM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IEA --
GO:0005887 integral component of plasma membrane TAS 8995416
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ICAM5: view

Pathways & Interactions for ICAM5 Gene

genes like me logo Genes that share pathways with ICAM5: view

Gene Ontology (GO) - Biological Process for ICAM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006909 phagocytosis IEA --
GO:0007155 cell adhesion IBA --
GO:0016337 single organismal cell-cell adhesion IEA --
GO:0030198 extracellular matrix organization TAS --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with ICAM5: view

No data available for SIGNOR curated interactions for ICAM5 Gene

Drugs & Compounds for ICAM5 Gene

No Compound Related Data Available

Transcripts for ICAM5 Gene

Unigene Clusters for ICAM5 Gene

Intercellular adhesion molecule 5, telencephalin:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ICAM5 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: - -

Relevant External Links for ICAM5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ICAM5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ICAM5 Gene

mRNA differential expression in normal tissues according to GTEx for ICAM5 Gene

This gene is overexpressed in Brain - Hippocampus (x6.8), Brain - Nucleus accumbens (basal ganglia) (x6.6), Brain - Cortex (x6.5), Brain - Anterior cingulate cortex (BA24) (x5.7), Brain - Frontal Cortex (BA9) (x5.5), and Brain - Putamen (basal ganglia) (x4.3).

Protein differential expression in normal tissues from HIPED for ICAM5 Gene

This gene is overexpressed in Brain (39.9) and Frontal cortex (25.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ICAM5 Gene

Protein tissue co-expression partners for ICAM5 Gene

NURSA nuclear receptor signaling pathways regulating expression of ICAM5 Gene:


SOURCE GeneReport for Unigene cluster for ICAM5 Gene:


mRNA Expression by UniProt/SwissProt for ICAM5 Gene:

Tissue specificity: Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon.

Evidence on tissue expression from TISSUES for ICAM5 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ICAM5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ICAM5 Gene

Orthologs for ICAM5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ICAM5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ICAM5 33 34
  • 94.63 (n)
(Canis familiaris)
Mammalia ICAM5 33 34
  • 87.2 (n)
(Bos Taurus)
Mammalia ICAM5 33 34
  • 86.91 (n)
(Mus musculus)
Mammalia Icam5 33 16 34
  • 82.08 (n)
(Rattus norvegicus)
Mammalia Icam5 33
  • 81.79 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 29 (a)
-- 34
  • 22 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia icam5 33
  • 45.4 (n)
Species where no ortholog for ICAM5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ICAM5 Gene

Gene Tree for ICAM5 (if available)
Gene Tree for ICAM5 (if available)

Paralogs for ICAM5 Gene

Paralogs for ICAM5 Gene

(4) SIMAP similar genes for ICAM5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ICAM5: view

Variants for ICAM5 Gene

Sequence variations from dbSNP and Humsavar for ICAM5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_035515 A breast cancer sample
VAR_035516 A breast cancer sample
VAR_035517 A breast cancer sample
rs1000071669 -- 10,295,469(+) GCCCC(C/T)GGGGG reference, missense
rs1000131028 -- 10,289,747(+) AGCGT(C/G)GTCGC intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ICAM5 Gene

Variant ID Type Subtype PubMed ID
nsv953974 CNV deletion 24416366
nsv470124 CNV gain 18288195

Variation tolerance for ICAM5 Gene

Residual Variation Intolerance Score: 15.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.33; 96.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ICAM5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICAM5 Gene

Disorders for ICAM5 Gene

Relevant External Links for ICAM5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ICAM5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ICAM5 Gene

Publications for ICAM5 Gene

  1. Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2. (PMID: 9828136) Kilgannon P … Gallatin WM (Genomics 1998) 2 3 4 22 60
  2. cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1. (PMID: 8995416) Mizuno T … Mori K (The Journal of biological chemistry 1997) 2 3 4 22 60
  3. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 45 60
  4. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 45 60
  5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 45 60

Products for ICAM5 Gene

Sources for ICAM5 Gene

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