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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ICAM5 Gene

protein-coding   GIFtS: 56
GCID: GC19P010400

intercellular adhesion molecule 5, telencephalin


(Previous symbol: TLCN)
 Explore 18 diseases affiliated with
ICAM5 via our new
 Human Malady Compendium 
Biological research products
for ICAM5
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Intercellular Adhesion Molecule 5, Telencephalin1 2     Intercellular Adhesion Molecule 52
TLCN1 2 3 5     Telencephalin3
TLN1 2 3 5     Telencephalin3
ICAM-52 3     

External Ids:    HGNC: 53481   Entrez Gene: 70872   Ensembl: ENSG000001053767   OMIM: 6018525   UniProtKB: Q9UMF03   

Export aliases for ICAM5 gene to outside databases

Previous GC identifers: GC19P010522 GC19P010623 GC19P010246 GC19P010261 GC19P009980


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ICAM5:
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins
are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte
adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of
adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may
be a critical component in neuron-microglial cell interactions in the course of normal development or as part of
neurodegenerative diseases. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ICAM5_HUMAN, Q9UMF0
Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2)

Gene Wiki entry for ICAM5


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ICAM5 gene promoter:
         GR   STAT1   AP-2alpha isoform 3   STAT1beta   AP-2alpha isoform 2   STAT1alpha   AP-2alpha isoform 4   GR-alpha   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidICAM5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ICAM5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ICAM5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ICAM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ICAM5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P010400:  view genomic region     (about GC identifiers)

Start:
10,400,655 bp from pter      End:
10,407,454 bp from pter
Size:
6,800 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ICAM5_HUMAN, Q9UMF0 (See protein sequence)
Recommended Name: Intercellular adhesion molecule 5 precursor  
Size: 924 amino acids; 97116 Da
Subcellular location: Membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for ICAM5:
3BN3 (3D)    
Secondary accessions: Q9Y6F3

Explore the universe of human proteins at neXtProt for ICAM5: NX_Q9UMF0

Post-translational modifications:

  • Glycosylation at Asn-54 is critical for functional folding (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UMF0

  • ICAM5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003250.3  
    ENSEMBL proteins: 
     ENSP00000221980   ENSP00000464796  

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    Uscn Proteins for ICAM5

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS8995416
    GO:0005887integral to plasma membrane TAS8995416


    ICAM5 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ICAM5 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR003598 Ig_sub2
     IPR003988 ICAM
     IPR013768 ICAM_N
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9UMF0

    ProtoNet protein and cluster: Q9UMF0

    5 Blocks protein families:
    IPB003598 Immunoglobulin C-2 type
    IPB003987 Intercellular adhesion molecule/vascular cell adhesion molecule-1 signature
    IPB003988 Intercellular adhesion molecule (ICAM) family signature
    IPB013098 Immunoglobulin I-set
    IPB013768 Intercellular adhesion molecule


    UniProtKB/Swiss-Prot: ICAM5_HUMAN, Q9UMF0
    Similarity: Belongs to the immunoglobulin superfamily. ICAM family
    Similarity: Contains 9 Ig-like C2-type (immunoglobulin-like) domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ICAM5_HUMAN, Q9UMF0
    Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2)

         Genatlas biochemistry entry for ICAM5:
    intercellular adhesion molecule 5,telencephalin,ligand for LFA1,brain segment specific neuronal adhesion molecule,Ig
    superfamily,highly homolog to ICAM1,ICAM3,expressed in cell body and dendrites of neurons in the telencephalin from
    birth and throughout life

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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16820411


    ICAM5 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ICAM5:
     Increased circadian period len 

    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Icam5):
     behavior/neurological  nervous system 

    ICAM5 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ICAM5

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for ICAM5 (Q9UMF01, 3 ENSP000002219804) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSEN1P497683, ENSP000003263664I2D: score=3 STRING: ENSP00000326366
    CSF1P096033, ENSP000003275134I2D: score=1 STRING: ENSP00000327513
    ITGB2P051073, ENSP000003032424I2D: score=1 STRING: ENSP00000303242
    ITGALP207013, ENSP000003492524I2D: score=1 STRING: ENSP00000349252
    PSEN2P498103, ENSP000003557474I2D: score=3 STRING: ENSP00000355747
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006909phagocytosis IEA--
    GO:0016337cell-cell adhesion IEA--


    ICAM5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ICAM5
    Search CenterWatch for drugs/clinical trials and news about ICAM5 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ICAM5 gene: 
    NM_003259.3  

    Unigene Cluster for ICAM5:

    Intercellular adhesion molecule 5, telencephalin
    Hs.465862  [show with all ESTs]
    Unigene Representative Sequence: BC026338
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000221980(uc002mnu.4 uc002mnv.4) ENST00000588912 ENST00000586004
    ENST00000587398 ENST00000586480

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    hsa-miR-3163 hsa-miR-548am hsa-miR-3132 hsa-miR-548x hsa-miR-340
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    Inhib. RNA
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    Additional cDNA sequence: 

    AK295887.1 BC026338.1 BC030132.2 U72671.1 

    2 DOTS entries:

    DT.209677  DT.97805583 

    24/33 AceView cDNA sequences (see all 33):

    AI769028 BF732427 BC026338 BX106276 AW276559 AI085324 BV174838 BM544595 
    BV183832 U72671 BV188540 NM_003259 BF527698 BM921826 BU689127 AI568610 
    AI199660 BC030132 BE163470 BG701036 R61108 AI811252 BM805464 AI968424 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ICAM5    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:              -                                                                                 
    SP2:              -           -                                                                     
    SP3:                                                                                                


    ECgene alternative splicing isoforms for ICAM5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ICAM5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAAGCCACG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ICAM5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ICAM5

    SOURCE GeneReport for Unigene cluster: Hs.465862

    UniProtKB/Swiss-Prot: ICAM5_HUMAN, Q9UMF0
    Tissue specificity: Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ICAM5 gene from 1/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia ICAM46
    --
    --
    30(a)
    30(a)
    many ↔ many
    many ↔ many
    GL343233.1(1353200-1357090)
    GL344305.1(34371-49910)


    ENSEMBL Gene Tree for ICAM5 (if available)
    TreeFam Gene Tree for ICAM5 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ICAM5 gene
    ICAM42  ICAM22  ICAM12  ICAM32  
    4 SIMAP similar genes for ICAM5 using alignment to 4 protein entries:     ICAM5_HUMAN (see all proteins):
    ICAM3    P3.58    ICAM1    ICAM-1

    ICAM5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/155 NCBI SNPs in ICAM5 are shown (see all 155    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1836884561,2
    --10399770(+) GAATTC/TTGACG 1 -- us2k10--------
    rs346695511,2
    C,--10399785(+) TCTGGT/CAGTCA 1 -- us2k14Minor allele frequency- C:0.01NS NA 98
    rs779230451,2
    F,--10399823(+) GGGTGG/AGGGGT 1 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1894302861,2
    --10399889(+) CTCGCA/GTGGAT 1 -- us2k10--------
    rs25696931,2
    C,F,H,--10399904(+) GGGCCC/TCCACC 1 -- us2k120Minor allele frequency- T:0.27NA EA NS WA 3392
    rs1815259271,2
    --10399955(+) TCGAGC/GTCACA 1 -- us2k10--------
    rs1163812631,2
    F,--10399988(+) GCTGCA/CCCCTG 1 -- us2k11Minor allele frequency- C:0.05WA 118
    rs350993611,2
    C,F,--10400025(+) GATTCT/CAATTT 1 -- us2k15Minor allele frequency- C:0.03NS NA WA 216
    rs2814391,2
    C,F,H,--10400110(+) CGTGCC/GGGAGC 1 -- us2k116Minor allele frequency- G:0.34MN NS EA NA WA CSA 1065
    rs2814401,2
    C,F,A,H,--10400304(+) GGCGGA/GGCTCG 1 -- us2k136Minor allele frequency- G:0.36EA NA MN NS WA CSA 4345

    HapMap Linkage Disequilibrium report for ICAM5 (10400655 - 10407454 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ICAM5
         1 CNV: 29685
    Human Gene Mutation Database (HGMD): ICAM5

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ICAM5 for disorders           About GeneDecksing

    OMIM gene information: 601852    OMIM disorders: --

    18 diseases for ICAM5:    About MalaCards
    neuronitis    neurodegenerative disease    febrile seizures    holoprosencephaly
    multiple myeloma    alzheimer's disease    seizures    hepatitis c
    hepatitis b    encephalitis    myeloma    meningioma
    hepatitis    prostate cancer    breast cancer    prostatitis
    leukemia    carcinoma

    1 Novoseek disease relationship for ICAM5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 11.4 2 9125424 (2)

    Human Genome Epidemiology (HuGE) Navigator: ICAM5 (16 documents)

    Export disorders for ICAM5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ICAM5 gene, integrated from 9 sources (see all 55):
    (articles sorted by number of sources associating them with ICAM5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1. (PubMed id 8995416)1, 2, 3, 9 Mizuno T.... Mori K. (1997)
    2. Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2. (PubMed id 9828136)1, 2, 3, 9 Kilgannon P.... Gallatin W.M. (1998)
    3. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
    4. Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction with the leukocyte integrin CD11a/CD18. (PubMed id 10741396)1, 9 Tian L....Gahmberg C.G. (2000)
    5. Neuronal adhesion molecule telencephalin induces rapid cell spreading of microglia. (PubMed id 10592287)1, 9 Mizuno T....Mori K. (1999)
    6. Development of telencephalin in the human cerebrum. (PubMed id 10402269)1, 9 Arii N....Takashima S. (1999)
    7. Telencephalin: a neuronal area code molecule? (PubMed id 7724062)1, 9 Yoshihara Y. and Mori K. (1994)
    8. Shedded neuronal ICAM-5 suppresses T-cell activation. (PubMed id 18223167)1, 9 Tian L....Gahmberg C.G. (2008)
    9. Polarized distribution and cell type-specific localization of telencephalin, an intercellular adhesion molecule. (PubMed id 9556028)1, 9 Benson D.L....Mori K. (1998)
    10. Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins. (PubMed id 11719200)1, 9 Annaert W.G....De Strooper B. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7087 HGNC: 5348 AceView: ICAM5 Ensembl:ENSG00000105376 euGenes: HUgn7087
    ECgene: ICAM5 H-InvDB: ICAM5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ICAM5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ICAM5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ICAM5 gene:
    Search GeneIP for patents involving ICAM5

    GeneCards and IP:
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