Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ICAM5 Gene

protein-coding   GIFtS: 60
GCID: GC19P010400

Intercellular Adhesion Molecule 5, Telencephalin


(Previous symbol: TLCN)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Intercellular Adhesion Molecule 5, Telencephalin1 2     ICAM-52 3
TLCN1 2 3 5     Intercellular Adhesion Molecule 52
TLN2 3 5     Telencephalin3
telencephalin1 2     

External Ids:    HGNC: 53481   Entrez Gene: 70872   Ensembl: ENSG000001053767   OMIM: 6018525   UniProtKB: Q9UMF03   

Export aliases for ICAM5 gene to outside databases

Previous GC identifers: GC19P010522 GC19P010623 GC19P010246 GC19P010261 GC19P009980


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ICAM5 Gene:
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM
proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the
leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays
two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and
leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal
development or as part of neurodegenerative diseases. (provided by RefSeq, Jul 2008)

GeneCards Summary for ICAM5 Gene:
ICAM5 (intercellular adhesion molecule 5, telencephalin) is a protein-coding gene. Diseases associated with ICAM5 include febrile seizures, and breast and colorectal cancer. An important paralog of this gene is ICAM4.

UniProtKB/Swiss-Prot: ICAM5_HUMAN, Q9UMF0
Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2)

Gene Wiki entry for ICAM5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the ICAM5 gene promoter:
         GR   STAT1   AP-2alpha isoform 3   STAT1beta   AP-2alpha isoform 2   STAT1alpha   AP-2alpha isoform 4   GR-alpha   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidICAM5 promoter sequence
   Search Chromatin IP Primers for ICAM5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ICAM5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ICAM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ICAM5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P010400:  view genomic region     (about GC identifiers)

Start:
10,400,655 bp from pter      End:
10,407,454 bp from pter
Size:
6,800 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ICAM5_HUMAN, Q9UMF0 (See protein sequence)
Recommended Name: Intercellular adhesion molecule 5 precursor  
Size: 924 amino acids; 97116 Da
1 PDB 3D structure from and Proteopedia for ICAM5:
3BN3 (3D)    
Secondary accessions: Q9Y6F3

Explore the universe of human proteins at neXtProt for ICAM5: NX_Q9UMF0

Explore proteomics data for ICAM5 at MOPED

Post-translational modifications: 

  • Glycosylation at Asn-54 is critical for functional folding (By similarity)1
  • Glycosylation2 at Asn54, Asn74, Asn137, Asn195, Asn214, Asn303, Asn316, Asn371, Asn397, Asn583,
                                 Asn646, Asn764, Asn795, Asn796
  • Modification sites at PhosphoSitePlus

  • See ICAM5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003250.3  
    ENSEMBL proteins: 
     ENSP00000221980   ENSP00000464796  

    ICAM5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ICAM5 (ICAM-5)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ICAM5
    GenScript Custom Purified and Recombinant Proteins Services for ICAM5
    Novus Biologicals ICAM5 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ICAM5

    ICAM5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for ICAM5 (ICAM-5)
    OriGene Antibodies for ICAM5
    OriGene Custom Antibody Services for ICAM5
    Novus Biologicals ICAM5 Antibodies
    Abcam antibodies for ICAM5
    Cloud-Clone Corp. Antibodies for ICAM5
    ThermoFisher Antibodies for ICAM5
    LSBio Antibodies in human, mouse, rat for ICAM5

    ICAM5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ICAM5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ICAM5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ICAM5
    Cloud-Clone Corp. CLIAs for ICAM5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    7 InterPro protein domains (see first 5):
     IPR003598 Ig_sub2
     IPR003988 ICAM
     IPR013768 ICAM_N
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR003987 ICAM_VCAM_N

    Graphical View of Domain Structure for InterPro Entry Q9UMF0

    ProtoNet protein and cluster: Q9UMF0

    5 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB003987 Intercellular adhesion molecule/vascular cell adhesion molecule-1 signature
    IPB003988 Intercellular adhesion molecule (ICAM) family signature
    IPB013098 Immunoglobulin I-set
    IPB013768 Intercellular adhesion molecule


    UniProtKB/Swiss-Prot: ICAM5_HUMAN, Q9UMF0
    Similarity: Belongs to the immunoglobulin superfamily. ICAM family
    Similarity: Contains 9 Ig-like C2-type (immunoglobulin-like) domains


    ICAM5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ICAM5_HUMAN, Q9UMF0
    Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2)

         Genatlas biochemistry entry for ICAM5:
    intercellular adhesion molecule 5,telencephalin,ligand for LFA1,brain segment specific neuronal adhesion
    molecule,Ig superfamily,highly homolog to ICAM1,ICAM3,expressed in cell body and dendrites of neurons in the
    telencephalin from birth and throughout life

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16820411
         
    ICAM5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ICAM5:
     Increased circadian period len 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Icam5):
     behavior/neurological  nervous system 

    ICAM5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ICAM5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ICAM5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ICAM5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ICAM5

    miRNA
    Products:
        
    miRTarBase miRNAs that target ICAM5:
    hsa-mir-26b-5p (MIRT029186), hsa-mir-124-3p (MIRT022419)

    Block miRNA regulation of human, mouse, rat ICAM5 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate ICAM5:
    hsa-miR-3163 hsa-miR-548am hsa-miR-3132 hsa-miR-548x hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidICAM5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ICAM5
    Predesigned siRNA for gene silencing in human, mouse, rat ICAM5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ICAM5

    Clone
    Products:
         
    OriGene clones in human, mouse for ICAM5 (see all 5)
    OriGene ORF clones in mouse, rat for ICAM5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ICAM5 (NM_003259)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ICAM5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICAM5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ICAM5
    Browse ESI BIO Cell Lines and PureStem Progenitors for ICAM5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ICAM5_HUMAN, Q9UMF0: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    nucleus2
    cytosol1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS8995416
    GO:0005887integral component of plasma membrane TAS8995416

    ICAM5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ICAM5
    Interactions:

        GeneGlobe Interaction Network for ICAM5

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for ICAM5 (Q9UMF01, 3 ENSP000002219804) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSEN1P497683, ENSP000003263664I2D: score=3 STRING: ENSP00000326366
    CSF1P096033, ENSP000003275134I2D: score=1 STRING: ENSP00000327513
    ITGB2P051073, ENSP000003032424I2D: score=1 STRING: ENSP00000303242
    ITGALP207013, ENSP000003492524I2D: score=1 STRING: ENSP00000349252
    PSEN2P498103, ENSP000003557474I2D: score=3 STRING: ENSP00000355747
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006909phagocytosis IEA--
    GO:0016337cell-cell adhesion IEA--

    ICAM5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ICAM5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ICAM5 gene: 
    NM_003259.3  

    Unigene Cluster for ICAM5:

    Intercellular adhesion molecule 5, telencephalin
    Hs.465862  [show with all ESTs]
    Unigene Representative Sequence: BC026338
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000221980(uc002mnu.4 uc002mnv.4) ENST00000588912 ENST00000586004
    ENST00000587398 ENST00000586480
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ICAM5 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate ICAM5:
    hsa-miR-3163 hsa-miR-548am hsa-miR-3132 hsa-miR-548x hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidICAM5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ICAM5
    Predesigned siRNA for gene silencing in human, mouse, rat ICAM5
    Clone
    Products:
         
    OriGene clones in human, mouse for ICAM5 (see all 5)
    OriGene ORF clones in mouse, rat for ICAM5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ICAM5 (NM_003259)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ICAM5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICAM5
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ICAM5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ICAM5
      QuantiTect SYBR Green Assays in human, mouse, rat ICAM5
      QuantiFast Probe-based Assays in human, mouse, rat ICAM5

    Additional mRNA sequence: 

    AK295887.1 BC026338.1 BC030132.2 U72671.1 

    2 DOTS entries:

    DT.209677  DT.97805583 

    Selected AceView cDNA sequences (see all 33):

    BF732427 AI769028 U72671 BM544595 AW276559 BV174838 AI085324 BM921826 
    NM_003259 BC026338 BV183832 BC030132 BV188540 BF527698 AI568610 BX106276 
    BU689127 AI199660 R61108 AI811252 BG701036 BE163470 BM805464 AI968424 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ICAM5    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:              -                                                                                 
    SP2:              -           -                                                                     
    SP3:                                                                                                


    ECgene alternative splicing isoforms for ICAM5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ICAM5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAGCCACG
    ICAM5 Expression
    About this image


    ICAM5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 23 entries
             Thalamus
             Septum   
    ICAM5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ICAM5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.465862

    UniProtKB/Swiss-Prot: ICAM5_HUMAN, Q9UMF0
    Tissue specificity: Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon

        Custom PCR Arrays for ICAM5
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ICAM5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ICAM5
    QuantiTect SYBR Green Assays in human, mouse, rat ICAM5
    QuantiFast Probe-based Assays in human, mouse, rat ICAM5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for ICAM5 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Icam51 , 5 intercellular adhesion molecule 5, telencephalin1, 5 82.08(n)1
    84.62(a)1
      9 (7.70 cM)5
    158981  NM_008319.21  NP_032345.21 
     210320385 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    29(a)
    22(a)
    many ↔ many
    many ↔ many
    GL344305.1(30522-49910)
    GL343233.1(1353200-1357090)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia icam51 intercellular adhesion molecule 5, telencephalin 45.4(n)
    36.21(a)
      497001  NM_001011498.1  NP_001011498.1 


    ENSEMBL Gene Tree for ICAM5 (if available)
    TreeFam Gene Tree for ICAM5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ICAM5 gene
    ICAM42  ICAM22  ICAM12  ICAM32  
    4 SIMAP similar genes for ICAM5 using alignment to 4 protein entries:     ICAM5_HUMAN (see all proteins):
    ICAM3    P3.58    ICAM1    ICAM-1

    ICAM5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ICAM5 (see all 219)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0355154
    A breast cancer sample4--see VAR_0355152 L V mis40--------
    VAR_0355174
    A breast cancer sample4--see VAR_0355172 E Q mis40--------
    VAR_0355164
    A breast cancer sample4--see VAR_0355162 R W mis40--------
    rs1836884561,2
    --10399770(+) GAATTC/TTGACG 1 -- us2k10--------
    rs346695511,2
    C--10399785(+) TCTGGT/CAGTCA 1 -- us2k14Minor allele frequency- C:0.01NS NA 98
    rs779230451,2
    F--10399823(+) GGGTGG/AGGGGT 1 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1894302861,2
    --10399889(+) CTCGCA/GTGGAT 1 -- us2k10--------
    rs25696931,2
    C,F,H--10399904(+) GGGCCC/TCCACC 1 -- us2k120Minor allele frequency- T:0.27NA EA NS WA 3392
    rs1815259271,2
    --10399955(+) TCGAGC/GTCACA 1 -- us2k10--------
    rs1163812631,2
    C,F--10399988(+) GCTGCA/CCCCTG 1 -- us2k11Minor allele frequency- C:0.05WA 118

    HapMap Linkage Disequilibrium report for ICAM5 (10400655 - 10407454 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for ICAM5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911030CNV Loss21882294
    nsv911029CNV Loss21882294
    dgv3726n71CNV Loss21882294
    dgv3725n71CNV Loss21882294
    nsv911033CNV Gain21882294
    nsv470124CNV Gain18288195
    nsv911037CNV Gain21882294

    Human Gene Mutation Database (HGMD): ICAM5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ICAM5
    DNA2.0 Custom Variant and Variant Library Synthesis for ICAM5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601852    OMIM disorders: --

    20 diseases for ICAM5:    
    About MalaCards
    febrile seizures    breast and colorectal cancer    holoprosencephaly    childhood leukemia
    multiple myeloma    neuronitis    hepatitis c virus    alzheimer's disease
    meningioma    encephalitis    myeloma    hepatitis c
    hepatitis b    hepatitis    prostate cancer    prostatitis
    cerebritis    breast cancer    colorectal cancer    leukemia


    ICAM5 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ICAM5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 11.4 2 9125424 (2)

    Genetic Association Database (GAD): ICAM5
    Human Genome Epidemiology (HuGE) Navigator: ICAM5 (16 documents)

    Export disorders for ICAM5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ICAM5 gene, integrated from 10 sources (see all 57):
    (articles sorted by number of sources associating them with ICAM5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1. (PubMed id 8995416)1, 2, 3, 9 Mizuno T.... Mori K. (J. Biol. Chem. 1997)
    2. Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2. (PubMed id 9828136)1, 2, 3, 9 Kilgannon P.... Gallatin W.M. (Genomics 1998)
    3. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    4. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    5. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    6. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    9. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (amp 2009)
    10. A common coding variant in CASP8 is associated with breast cancer risk. (PubMed id 17293864)1, 4 Cox A....Easton D.F. (Nat. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7087 HGNC: 5348 AceView: ICAM5 Ensembl:ENSG00000105376 euGenes: HUgn7087
    ECgene: ICAM5 H-InvDB: ICAM5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ICAM5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ICAM5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ICAM5 gene:
    Search GeneIP for patents involving ICAM5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for ICAM5 (ICAM-5)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for ICAM5 (ICAM-5)   Browse Stem Cell Products  
     cDNA Clones for ICAM5 (ICAM-5)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ICAM5   OriGene RNAi products in human, mouse, rat for ICAM5  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ICAM5  
     OriGene qSTAR qPCR primer pairs in human, mouse for ICAM5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ICAM5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ICAM5   OriGene Custom Protein Services for ICAM5  

     
     
     Block miRNA regulation of human, mouse, rat ICAM5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ICAM5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ICAM5 Predesigned siRNA for gene silencing in human, mouse, rat ICAM5
     QuantiFast Probe-based Assays in human, mouse, rat ICAM5 QuantiTect SYBR Green Assays in human, mouse, rat ICAM5
     Custom PCR Arrays for ICAM5 Search Chromatin IP Primers for ICAM5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ICAM5  GeneGlobe Interaction Network for ICAM5
     Regulatory tfbs in ICAM5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ICAM5 GenScript cDNA clones with any tag delivered in your preferred vector for ICAM5
     GenScript Custom Assay Services for ICAM5 GenScript Custom overexpressing Cell Line Services for ICAM5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ICAM5
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ICAM5 antibodies
     ICAM5 proteins
     Antibodies for ICAM5
     See all of Abcam's Antibodies, Kits and Proteins for ICAM5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ICAM5
     Antibodies for ICAM5
     ELISAs for ICAM5
     CLIAs for ICAM5



     Browse ESI BIO Cell Lines and PureStem Progenitors for ICAM5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM5
     SwitchGear 3'UTR luciferase reporter plasmids for ICAM5
     SwitchGear Promoter luciferase reporter plasmids for ICAM5
     ThermoFisher Antibodies for ICAM5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICAM5
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ICAM5
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ICAM5
     LSBio Antibodies in human, mouse, rat for ICAM5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ICAM5 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4