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Aliases & Descriptions for ICAM5
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| ICAM-5 3 | | TLCN 2, 3, 5 | | TLN 1, 2, 3, 5 | | Telencephalin 3 | | telencephalin 2 |
| | | Descriptions |
|---|
| intercellular adhesion molecule 5 2 | | intercellular adhesion molecule 5, telencephalin 2 |
|
| | Search outside databases for aliases for ICAM5 genePrevious GC identifers: GC19P010522 GC19P010623 GC19P010246 |
Summaries for ICAM5(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ICAM5: The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq] UniProtKB/Swiss-Prot: ICAM5_HUMAN, Q9UMF0Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2)Gene Wiki entry for ICAM5 |
Genomic Location for ICAM5
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ICAM5 gene 
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2ICAM5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P010261:
(about GC identifiers)
Start:
|
10,261,655 bp from pter |
End:
|
10,268,453 bp from pter |
Size:
|
6,799 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011295.10
| Proteins for ICAM5
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ICAM5_HUMAN, Q9UMF0 (See
protein sequence)Recommended Name: Intercellular adhesion molecule 5 precursor Size: 924 amino acids; 97331 Da
Subcellular location: Membrane; Single-pass type I membrane protein
PDB structures from and Proteopedia :3BN3 (3D)
 
Secondary accessions: Q9Y6F3Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_003250.3
ENSEMBL proteins: ENSP00000221980
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for ICAM5: Assays for ICAM5: | Protein
Domains/ Families for ICAM5(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9UMF0
ProtoNet protein and cluster: Q9UMF0 5 Blocks protein families: IPB003598 Immunoglobulin C-2 type IPB003987 Intercellular adhesion molecule/vascular cell adhesion molecule-1 signature IPB003988 Intercellular adhesion molecule (ICAM) family signature IPB013098 Immunoglobulin I-set IPB013768 Intercellular adhesion molecule
UniProtKB/Swiss-Prot: ICAM5_HUMAN, Q9UMF0Similarity: Belongs to the immunoglobulin superfamily. ICAM familySimilarity: Contains 9 Ig-like C2-type (immunoglobulin-like) domains | Gene Function for ICAM5
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003259
Applied Biosystems Silencer® siRNAs for ICAM5
Sigma-Aldrich siRNA and siRNA Panels for ICAM5  Sigma-Aldrich shRNA for ICAM5  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003259                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003259                                  untagged cDNA clone in CMV expression vector: NM_003259 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003259
UniProtKB/Swiss-Prot: ICAM5_HUMAN, Q9UMF0Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2)Genatlas biochemistry entry for ICAM5:intercellular adhesion molecule 5,telencephalin,ligand for LFA1,brain segment specific neuronal adhesion molecule,Ig superfamily,highly homolog to ICAM1,ICAM3,expressed in cell body and dendrites of neurons in the telencephalin from birth and throughout life2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Icam5):
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IEA | -- | About this table | Pathways & Interactions for ICAM5
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for ICAM5 
5 Interacting proteins for ICAM5 (ENSP000002219803) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006909 | phagocytosis |
IEA | -- | | GO:0016337 | cell-cell adhesion |
IEA | -- | About this table
|
Drugs & Compounds for ICAM5(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ICAM5
|
Transcripts for ICAM5(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003259
Sigma-Aldrich siRNA and siRNA Panels for ICAM5  Sigma-Aldrich shRNA for ICAM5  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003259 REFSEQ mRNAs for ICAM5 gene: NM_003259.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003259               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003259                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003259                                  untagged cDNA clone in CMV expression vector: NM_003259  Additional cDNA sequence: AK295887.1 BC026338.1 BC030132.2 U72671.1 2 DOTS entries: DT.209677 DT.97805583 24/33 AceView cDNA sequences (see all 33
):BF732427 AI769028 NM_003259 BC030132 BF527698 AI199660 BX106276 BM544595 BV188540 BU689127 AI568610 BC026338 AW276559 AI085324 BV183832 U72671 BM921826 BV174838 BE163470 R61108 BG701036 AI811252 BM805464 AI968424
highest scoring ESTs for ICAM5:U72671 BC026338 BC030132 AI085324 AI199660 AI568610 AI769028 AI811252 AI968424 AW276559 Unigene Cluster for ICAM5: Intercellular adhesion molecule 5, telencephalin Hs.465862 [show with all ESTs]Unigene Representative Sequence: BC026338
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ICAM5
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | |
| SP1: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for ICAM5
1 Ensembl transcript including schematic representation: ENST00000221980
|
Expression for ICAM5
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ICAM5 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ICAM5
1 / 2 / 3 3 probe-sets matching ICAM5 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGAAGCCACG
SOURCE GeneReport for Unigene cluster: Hs.465862
Expression variation in blood from EXPOLDB for ICAM5 UniProtKB/Swiss-Prot: ICAM5_HUMAN, Q9UMF0Tissue specificity: Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon |
Orthologs for ICAM5
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ICAM5 gene from 4 species
About this table Species with no ortholog for ICAM5
ENSEMBL Gene Tree for ICAM5 | Paralogs for ICAM5(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ICAM5 gene
- ICAM22 ICAM12 ICAM32
|
SNPs/Variants for ICAM5(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ICAM5 (up to first 250kb)
|
Disorders & Mutations for ICAM5
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 601852
1 Novoseek disease relationship for ICAM5 gene
About this table
Human Gene Mutation Database: ICAM5 Human Genome Epidemiology Navigator: ICAM5 (3 documents)
|
Medical News for ICAM5(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ICAM5 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/39 PubMed articles for ICAM5 gene (see all 39
):- cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1. (PubMed id 8995416)1, 2, 3, 4 Mizuno T.... Mori K. (1997)
- Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2. (PubMed id 9828136)1, 2, 3, 4 Kilgannon P....Gallatin W.M. (1998)
- Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)3, 4 Brill L.M....Peters E.C. (2004)
- Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction with the leukocyte integrin CD11a/CD18. (PubMed id 10741396)1, 3 Tian L....Gahmberg C.G. (2000)
- Neuronal adhesion molecule telencephalin induces rapid cell spreading of microglia. (PubMed id 10592287)1, 3 Mizuno T....Mori K. (1999)
- Development of telencephalin in the human cerebrum. (PubMed id 10402269)1, 3 Arii N....Takashima S. (1999)
- Telencephalin: a neuronal area code molecule? (PubMed id 7724062)1, 3 Yoshihara Y. and Mori K. (1994)
- Shedded neuronal ICAM-5 suppresses T-cell activation. (PubMed id 18223167)1, 3 Tian L....Gahmberg C.G. (2008)
- Polarized distribution and cell type-specific localization of telencephalin, an intercellular adhesion molecule. (PubMed id 9556028)1, 3 Benson D.L....Mori K. (1998)
- Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins. (PubMed id 11719200)1, 3 Annaert W.G....De Strooper B. (2001)
|
Search for ICAM5
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ICAM5
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ICAM5
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ICAM5(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ICAM5(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ICAM5:

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