ICAM4 Gene

Aliases
for ICAM4 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC19P010519 GC19P010620 GC19P010242 GC19P010258 GC19P009977

Summaries
for ICAM4 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for ICAM4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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SwitchGear Promoter luciferase reporter plasmid: ICAM4 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ICAM4

ICAM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P010397:  view genomic region     (about GC identifiers)

Proteins
for ICAM4 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for ICAM4: NX_Q14773

Explore proteomics data for ICAM4 at MOPED

Post-translational modifications: 

ICAM4 Human Recombinant Protein Products:

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ICAM4 Antibody Products:

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Domains /
Families
for ICAM4 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q14773

Find genes that share domains with ICAM4           About GenesLikeMe

Function
for ICAM4 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

(inferred from 1 allele) (MGI details for Icam4)

genOway: Develop your customized and physiologically relevant rodent model for ICAM4

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		Predesigned siRNA for gene silencing in human, mouse, rat ICAM4

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for ICAM4

Clone Products:		OriGene clones in human, mouse for ICAM4 (see all 17) OriGene ORF clones in mouse, rat for ICAM4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		Sino Biological Human cDNA Clone for ICAM4
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM4

Localization
for ICAM4 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
extracellular	5
plasma membrane	5
mitochondrion	1

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Gene Ontology (GO): 3 cellular component terms:    About this table

Pathways & Interactions
for ICAM4 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for ICAM4 About     See pathways by source

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	SuperPath	Contained pathways About
1	Class I MHC mediated antigen processing and presentation	Adaptive Immune System 0.41
2	Degradation of the extracellular matrix	Extracellular matrix organization 0.34
3	Integrin cell surface interactions	Integrin cell surface interactions
4	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

2 Reactome Pathways for ICAM4

	Integrin cell surface interactions
	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Gene Ontology (GO): 3 biological process terms:    About this table

Drugs & Compounds
for ICAM4 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for ICAM4 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for ICAM4 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ICAM4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTGGCTGACG

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Blood (Hematopoietic System)    fully expand to see all 4 entries
Proerythroblasts Hematopoietic Bone Marrow
Bone Marrow CD105+ Cells
cord blood
Umbilical Cord (Extraembryonic Tissues)
cord blood
NULL (Uncategorized)
Embryoid bodies

Primer Products:		OriGene qPCR primer pairs and template standards for ICAM4 OriGene qSTAR qPCR primer pairs in human, mouse for ICAM4
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ICAM4
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM4

Orthologs
for ICAM4 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for ICAM4 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for ICAM4 gene

ICAM5²  ICAM2²  ICAM1²  ICAM3²  

Find genes that share paralogs with ICAM4           About GenesLikeMe

Genomic Variants
for ICAM4 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ICAM4 (see all 96)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs774936701,2,,4	C,F	non-pathogenic1	10334401(+)	TTACCA/GGCTGC	6	Q R	mis1		2		NA EU	5253
rs357138171,2	C	--	9977811(+)	CCCTTC/ATGGGT	6	/L /F	mis1		2		NA	4
rs1418825371,2	C	--	9977849(+)	GCAGCC/TGGGGA	6	P L	mis1		1		NA	3796
rs1506540721,2	C,F	--	9977855(+)	GGGGAA/GGTCAG	6	K R	mis1		1		NA	3956
rs2008321531,2		--	9977997(+)	TCCCTA/CGCGCA	6	L	syn1		0	--	--	--	--
rs50303841,2	C,F,H	--	9978068(+)	TGAGGG/AACAGG	3	--	int1		12		NS EA NA	1278
rs3723953381,2	C	--	9978073(+)	GACAGC/GGGCTC	3	--	int1		0	--	--	--	--
rs1998871731,2	C	--	9978078(+)	GGGCTC/TGGTCC	3	--	int1		0	--	--	--	--
rs1456824481,2	C	--	9978085(+)	GTCCCA/GGCTGG	3	--	int1		0	--	--	--	--
rs343851351,2	C,F,H	--	9978110(+)	GCTGGA/CAGAGG	3	--	int1		6		NS NA	500

HapMap Linkage Disequilibrium report for ICAM4 (10397643 - 10399198 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for ICAM4:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv911030	CNV	Loss	21882294
nsv911029	CNV	Loss	21882294
dgv3726n71	CNV	Loss	21882294
dgv3725n71	CNV	Loss	21882294
nsv911033	CNV	Gain	21882294
nsv911037	CNV	Gain	21882294

Human Gene Mutation Database (HGMD): ICAM4
Locus Specific Mutation Databases (LSDB): ICAM4

Blood Group Antigen Gene Mutation Database (BGMUT) blood group system

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ICAM4

DNA2.0 Custom Variant and Variant Library Synthesis for ICAM4

Disorders / Diseases
for ICAM4 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for ICAM4 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Characterization of the gene encoding the human LW blood group protein in LW+ and LW- phenotypes. (PubMed id 8639917)^{1, 2, 3, 9} Hermand P.... Bailly P. (Blood 1996)
2. The LW blood group glycoprotein is homologous to intercellular adhesion molecules. (PubMed id 8202485)^{1, 2, 9} Bailly P.... Cartron J.-P. (Proc. Natl. Acad. Sci. U.S.A. 1994)
3. Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci. (PubMed id 21533024)^{1, 4} ParAc G....Chasman D.I. (PLoS Genet. 2011)
4. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PubMed id 20416077)^{1, 4} Ban H.J....Park K.J. (BMC Genet. 2010)
5. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)^{1, 4} Rajaraman P....Inskip P.D. (amp 2010)
6. Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels. (PubMed id 20167578)^{1, 4} Barbalic M....Benjamin E.J. (Hum. Mol. Genet. 2010)
7. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)^{1, 4} Han S....Kang D. (Hum. Immunol. 2010)
8. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)^{1, 4} Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
9. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)^{1, 4} Lee K.M....Lan Q. (Am. J. Hematol. 2010)
10. Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: a Go-DARTS study. (PubMed id 20622166)^{1, 4} Palmer C.N....Pola R. (Diabetes 2010)

External Searches for ICAM4 gene

Genome Databases showing ICAM4 gene

Other Databases showing ICAM4 gene

Specialized Databases showing ICAM4 gene

Products
for ICAM4 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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