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Aliases for ICAM4 Gene

Aliases for ICAM4 Gene

  • Intercellular Adhesion Molecule 4 (Landsteiner-Wiener Blood Group) 2 3 5
  • Intercellular Adhesion Molecule 4 (LW Blood Group) 2 3
  • Landsteiner-Wiener Blood Group Glycoprotein 3 4
  • CD242 Antigen 3 4
  • LW 3 4
  • Intercellular Adhesion Molecule 4, Landsteiner-Wiener Blood Group 2
  • Landsteiner-Wiener Blood Group Antigen A 3
  • Intercellular Adhesion Molecule 4 3
  • Landsteiner-Wiener Blood Group 2
  • LW Blood Group Protein 4
  • LW Antigen A 3
  • ICAM-4 4
  • CD242 3

External Ids for ICAM4 Gene

Previous HGNC Symbols for ICAM4 Gene

  • LW

Previous GeneCards Identifiers for ICAM4 Gene

  • GC19P010519
  • GC19P010620
  • GC19P010242
  • GC19P010258
  • GC19P010397
  • GC19P009977

Summaries for ICAM4 Gene

Entrez Gene Summary for ICAM4 Gene

  • This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for ICAM4 Gene

ICAM4 (Intercellular Adhesion Molecule 4 (Landsteiner-Wiener Blood Group)) is a Protein Coding gene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Innate Immune System. GO annotations related to this gene include integrin binding. An important paralog of this gene is ICAM5.

UniProtKB/Swiss-Prot for ICAM4 Gene

  • ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICAM4 Gene

Genomics for ICAM4 Gene

Regulatory Elements for ICAM4 Gene

Enhancers for ICAM4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G010400 1.5 FANTOM5 ENCODE 12.4 +117.3 117251 6.5 HDGF FOXA2 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 ICAM1 ZNF846 LOC100419831 MRPL4 ICAM5 ICAM4 RAVER1 QTRT1 PDE4A ILF3-AS1
GH19G010338 1.2 Ensembl ENCODE 12.5 +52.4 52377 2.3 HDAC1 HDGF TBP TBL1XR1 WRNIP1 SIN3A NFXL1 ZNF48 YY1 ZNF121 ICAM3 ENSG00000167807 ZGLP1 TYK2 ICAM5 ICAM4 ICAM1 MRPL4 PIR48013
GH19G010250 1.1 Ensembl ENCODE 12 -36.8 -36767 0.4 HDAC1 RB1 ARNT ARID4B SIN3A KLF17 ZNF2 RAD21 ZNF121 ZNF143 ICAM4 ICAM5 EIF3G TYK2 C19orf66 MRPL4 S1PR2
GH19G010388 0.9 ENCODE 12.4 +102.1 102093 0.2 PKNOX1 SIN3A ARID4B RAD21 ZNF143 ZNF207 RELB IKZF2 DEK PAF1 ZGLP1 ICAM5 ICAM1 MRPL4 ICAM4 EIF3G GC19P010382 MIR1181
GH19G010390 0.8 ENCODE 12.4 +103.9 103903 0.2 RAD21 EGR1 ZNF143 RELB IKZF2 DEK EGR2 ZNF654 ZNF362 REST ZGLP1 ICAM5 ICAM1 MRPL4 ICAM4 EIF3G GC19P010382 MIR1181
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ICAM4 on UCSC Golden Path with GeneCards custom track

Genomic Location for ICAM4 Gene

Chromosome:
19
Start:
10,286,967 bp from pter
End:
10,288,584 bp from pter
Size:
1,618 bases
Orientation:
Plus strand

Genomic View for ICAM4 Gene

Genes around ICAM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICAM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICAM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICAM4 Gene

Proteins for ICAM4 Gene

  • Protein details for ICAM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14773-ICAM4_HUMAN
    Recommended name:
    Intercellular adhesion molecule 4
    Protein Accession:
    Q14773
    Secondary Accessions:
    • A0M8X2
    • Q14771
    • Q14772
    • Q16375
    • Q9BWR0

    Protein attributes for ICAM4 Gene

    Size:
    271 amino acids
    Molecular mass:
    29265 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ICAM4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ICAM4 Gene

Post-translational modifications for ICAM4 Gene

Other Protein References for ICAM4 Gene

Antibody Products

  • Abcam antibodies for ICAM4
  • Cloud-Clone Corp. Antibodies for ICAM4

No data available for DME Specific Peptides for ICAM4 Gene

Domains & Families for ICAM4 Gene

Suggested Antigen Peptide Sequences for ICAM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14773

UniProtKB/Swiss-Prot:

ICAM4_HUMAN :
  • Belongs to the immunoglobulin superfamily. ICAM family.
Family:
  • Belongs to the immunoglobulin superfamily. ICAM family.
genes like me logo Genes that share domains with ICAM4: view

Function for ICAM4 Gene

Molecular function for ICAM4 Gene

GENATLAS Biochemistry:
adhesion molecule,intercellular 4
UniProtKB/Swiss-Prot Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.

Gene Ontology (GO) - Molecular Function for ICAM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding TAS 8566017
genes like me logo Genes that share ontologies with ICAM4: view
genes like me logo Genes that share phenotypes with ICAM4: view

Animal Models for ICAM4 Gene

MGI Knock Outs for ICAM4:

Animal Model Products

CRISPR Products

miRNA for ICAM4 Gene

miRTarBase miRNAs that target ICAM4

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ICAM4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ICAM4 Gene

Localization for ICAM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICAM4 Gene

Isoform Long: Cell membrane; Single-pass type I membrane protein.
Isoform Short: Secreted.
Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ICAM4 gene
Compartment Confidence
plasma membrane 5
extracellular 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ICAM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
genes like me logo Genes that share ontologies with ICAM4: view

Pathways & Interactions for ICAM4 Gene

genes like me logo Genes that share pathways with ICAM4: view

Gene Ontology (GO) - Biological Process for ICAM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IBA,IEA --
GO:0016337 single organismal cell-cell adhesion IEA --
GO:0030198 extracellular matrix organization TAS --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with ICAM4: view

No data available for SIGNOR curated interactions for ICAM4 Gene

Drugs & Compounds for ICAM4 Gene

No Compound Related Data Available

Transcripts for ICAM4 Gene

Unigene Clusters for ICAM4 Gene

Intercellular adhesion molecule 4 (Landsteiner-Wiener blood group):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ICAM4

Alternative Splicing Database (ASD) splice patterns (SP) for ICAM4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2:

Relevant External Links for ICAM4 Gene

GeneLoc Exon Structure for
ICAM4
ECgene alternative splicing isoforms for
ICAM4

Expression for ICAM4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ICAM4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ICAM4 Gene

This gene is overexpressed in Whole Blood (x15.1) and Lung (x9.4).

NURSA nuclear receptor signaling pathways regulating expression of ICAM4 Gene:

ICAM4

SOURCE GeneReport for Unigene cluster for ICAM4 Gene:

Hs.706750

mRNA Expression by UniProt/SwissProt for ICAM4 Gene:

Q14773-ICAM4_HUMAN
Tissue specificity: Erythrocytes.

Evidence on tissue expression from TISSUES for ICAM4 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with ICAM4: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ICAM4 Gene

Orthologs for ICAM4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ICAM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ICAM4 34 35
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia ICAM4 34 35
  • 79.39 (n)
cow
(Bos Taurus)
Mammalia ICAM4 34 35
  • 76.87 (n)
rat
(Rattus norvegicus)
Mammalia Icam4 34
  • 75.21 (n)
mouse
(Mus musculus)
Mammalia Icam4 34 16 35
  • 74.33 (n)
Species where no ortholog for ICAM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ICAM4 Gene

ENSEMBL:
Gene Tree for ICAM4 (if available)
TreeFam:
Gene Tree for ICAM4 (if available)

Paralogs for ICAM4 Gene

Paralogs for ICAM4 Gene

genes like me logo Genes that share paralogs with ICAM4: view

Variants for ICAM4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ICAM4 Gene

ICAM4_HUMAN-Q14773
Responsible for the Landsteiner-Wiener blood group system [MIM:111250]. The molecular basis of the LW(A)=LW5/LW(B)=LW7 blood group antigens is a single variation in position 100; Gln-100 corresponds to LW(A) and Arg-100 to LW(B).

Sequence variations from dbSNP and Humsavar for ICAM4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs77493670 other 10,287,311(+) TTACC(A/G)GCTGC reference, missense
rs1000675984 -- 10,285,576(+) GAGGG(A/G)AAGTG upstream-variant-2KB, utr-variant-3-prime
rs1001130557 -- 10,285,254(+) ACCCC(C/T)ATGAA upstream-variant-2KB, reference, synonymous-codon
rs1002288516 -- 10,285,542(+) CATGA(C/T)TGATG upstream-variant-2KB, utr-variant-3-prime
rs1002582178 -- 10,285,907(+) AGGTA(C/T)AGTTG upstream-variant-2KB, utr-variant-3-prime

Variation tolerance for ICAM4 Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ICAM4 Gene

Human Gene Mutation Database (HGMD)
ICAM4
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ICAM4

No data available for Structural Variations from Database of Genomic Variants (DGV) for ICAM4 Gene

Disorders for ICAM4 Gene

Relevant External Links for ICAM4

Genetic Association Database (GAD)
ICAM4
Human Genome Epidemiology (HuGE) Navigator
ICAM4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ICAM4

No disorders were found for ICAM4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ICAM4 Gene

Publications for ICAM4 Gene

  1. Characterization of the gene encoding the human LW blood group protein in LW+ and LW- phenotypes. (PMID: 8639917) Hermand P. … Bailly P. (Blood 1996) 2 3 4 22 64
  2. The LW blood group glycoprotein is homologous to intercellular adhesion molecules. (PMID: 8202485) Bailly P. … Cartron J.-P. (Proc. Natl. Acad. Sci. U.S.A. 1994) 3 4 22 64
  3. Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci. (PMID: 21533024) ParAc G. … Chasman D.I. (PLoS Genet. 2011) 3 46 64
  4. Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels. (PMID: 20167578) Barbalic M. … Benjamin E.J. (Hum. Mol. Genet. 2010) 3 46 64
  5. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3 46 64

Products for ICAM4 Gene

  • Addgene plasmids for ICAM4

Sources for ICAM4 Gene

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