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ICAM4 Gene

protein-coding   GIFtS: 58
GCID: GC19P010397

Intercellular Adhesion Molecule 4 (Landsteiner-Wiener Blood...

(Previous names: intercellular adhesion molecule 4, Landsteiner-Wiener blood...)
(Previous symbol: LW)
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Aliases
for ICAM4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Intercellular Adhesion Molecule 4 (Landsteiner-Wiener Blood Group)1 2     Intercellular Adhesion Molecule 4, Landsteiner-Wiener Blood Group1
LW1 2 3 5     Landsteiner-Wiener Blood Group1
Intercellular Adhesion Molecule 4 (LW Blood Group)1 2     Intercellular Adhesion Molecule 42
CD242 Antigen2 3     Intercellular Adhesion Molecule 4 Isoform 3 Anitgen LWa2
Landsteiner-Wiener Blood Group Glycoprotein2 3     Landsteiner-Wiener Blood Group Antigen A2
LW Blood Group Protein2 3     ICAM-43
CD2422 5     

External Ids:    HGNC: 53471   Entrez Gene: 33862   Ensembl: ENSG000001053717   OMIM: 6140885   UniProtKB: Q147733   

Export aliases for ICAM4 gene to outside databases

Previous GC identifers: GC19P010519 GC19P010620 GC19P010242 GC19P010258 GC19P009977


Summaries
for ICAM4 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ICAM4 Gene:
This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig)
superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM
protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis
of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100

GeneCards Summary for ICAM4 Gene:
ICAM4 (intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)) is a protein-coding gene. Diseases associated with ICAM4 include sickle cell disease, and childhood leukemia. GO annotations related to this gene include integrin binding. An important paralog of this gene is ICAM5.

UniProtKB/Swiss-Prot: ICAM4_HUMAN, Q14773
Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is
also a ligand for alpha-4/beta-1 and alpha-V integrins




Genomic Views
for ICAM4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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TryGeneCards Plus		 Regulatory elements:
   Regulatory transcription factor binding sites in the ICAM4 gene promoter:
         GR   STAT1   AP-2alpha isoform 3   AP-2alpha isoform 2   STAT1alpha   AP-2alpha isoform 4   GR-alpha   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ICAM4 promoter sequence
   Search Chromatin IP Primers for ICAM4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ICAM4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ICAM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ICAM4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P010397:  view genomic region     (about GC identifiers)

Start:
 10,397,643 bp from pter      End:
 10,399,198 bp from pter
Size:
 1,556 bases      Orientation:
 plus strand

Proteins
for ICAM4 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ICAM4_HUMAN, Q14773 (See protein sequence)
Recommended Name: Intercellular adhesion molecule 4 precursor  
Size: 271 amino acids; 29265 Da
Secondary accessions: A0M8X2 Q14771 Q14772 Q16375 Q9BWR0
Alternative splicing: 3 isoforms:  Q14773-1   Q14773-2   Q14773-3   

Explore the universe of human proteins at neXtProt for ICAM4: NX_Q14773

Explore proteomics data for ICAM4 at MOPED

Post-translational modifications: 

  • N- and O-glycosylated1
  • Glycosylation2 at Asn68, Asn78, Asn190, Asn223

    • See ICAM4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001034221.1  NP_001535.1  NP_071772.1  

    ENSEMBL proteins: 
     ENSP00000370147   ENSP00000342114   ENSP00000377320  
    Reactome Protein details: Q14773

    ICAM4 Human Recombinant Protein Products:

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    Novus Biologicals ICAM4 Proteins
    Novus Biologicals ICAM4 Lysates
    Sino Biological Recombinant Protein for ICAM4
    Sino Biological Cell Lysate for ICAM4
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    Cloud-Clone Corp. Proteins for ICAM4

    ICAM4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for ICAM4 (ICAM-4)
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    Abcam antibodies for ICAM4
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    Search ThermoFisher Antibodies for ICAM4
    LSBio Antibodies in human, mouse, rat for ICAM4

    ICAM4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ICAM4
    Cloud-Clone Corp. CLIAs for ICAM4

    Domains /
    Families
    for ICAM4 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 HGNC Gene Families:
    CD: CD molecules
    bloodgroup: Blood group antigens
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR013768 ICAM_N
     IPR013783 Ig-like_fold
     IPR003987 ICAM_VCAM_N

    Graphical View of Domain Structure for InterPro Entry Q14773

    ProtoNet protein and cluster: Q14773

    2 Blocks protein domains:
    IPB003987 Intercellular adhesion molecule/vascular cell adhesion molecule-1 signature
    IPB013768 Intercellular adhesion molecule


    UniProtKB/Swiss-Prot: ICAM4_HUMAN, Q14773
    Similarity: Belongs to the immunoglobulin superfamily. ICAM family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    ICAM4 for domains           About GeneDecksing


    Function
    for ICAM4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ICAM4_HUMAN, Q14773
    Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is
    also a ligand for alpha-4/beta-1 and alpha-V integrins

         Genatlas biochemistry entry for ICAM4:
    adhesion molecule,intercellular 4

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding TAS8566017
         
    ICAM4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ICAM4:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Icam4):
     hematopoietic system 

    ICAM4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Icam4tm1Jach for ICAM4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ICAM4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ICAM4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ICAM4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ICAM4

    miRNA
    Products:            		miRTarBase miRNAs that target ICAM4:
    hsa-mir-93-5p (MIRT048899)

    Block miRNA regulation of human, mouse, rat ICAM4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ICAM4
    SwitchGear 3'UTR luciferase reporter plasmid: ICAM4 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for ICAM4
    Predesigned siRNA for gene silencing in human, mouse, rat ICAM4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ICAM4

    Clone
    Products:             		 OriGene clones in human, mouse for ICAM4 (see all 17)
    OriGene ORF clones in mouse, rat for ICAM4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ICAM4 (NM_001544)
    Sino Biological Human cDNA Clone for ICAM4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ICAM4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICAM4

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ICAM4
    Browse ESI BIO Cell Lines and PureStem Progenitors for ICAM4 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM4


    Localization
    for ICAM4 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Subcellular locations from UniProtKB/Swiss-Prot
    ICAM4_HUMAN, Q14773: Isoform Long: Cell membrane; Single-pass type I membrane protein
    ICAM4_HUMAN, Q14773: Isoform Short: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    ICAM4 for ontologies           About GeneDecksing


    Pathways & Interactions
    for ICAM4 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ICAM4 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    		Adaptive Immune System0.41
    2Degradation of the extracellular matrix
    		Extracellular matrix organization0.34
    3Integrin cell surface interactions
    		Integrin cell surface interactions
    4Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for ICAM4
        Integrin cell surface interactions
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell



    ICAM4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ICAM4
    Interactions:

        GeneGlobe Interaction Network for ICAM4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for ICAM4 (Q147733 ENSP000003421144) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGAVP067563, ENSP000002610234I2D: score=1 STRING: ENSP00000261023
    ITGB2P051073, ENSP000003032424I2D: score=1 STRING: ENSP00000303242
    RHAGQ020943, ENSP000003602174I2D: score=1 STRING: ENSP00000360217
    ITGALP207013, ENSP000003492524I2D: score=1 STRING: ENSP00000349252
    ITGA4P136123, ENSP000003802274I2D: score=1 STRING: ENSP00000380227
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016337cell-cell adhesion IEA--
    GO:0030198extracellular matrix organization TAS--
    GO:0050776regulation of immune response TAS--

    ICAM4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ICAM4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ICAM4



    Transcripts
    for ICAM4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ICAM4 gene (3 alternative transcripts): 
    NM_001039132.2  NM_001544.4  NM_022377.3  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380770(uc002mns.2) ENST00000340992(uc002mnr.2) ENST00000393717(uc002mnt.2)


    miRNA
    Products:             		 Block miRNA regulation of human, mouse, rat ICAM4 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ICAM4
    SwitchGear 3'UTR luciferase reporter plasmid: ICAM4 3' UTR sequence
    Inhib. RNA
    Products:             		OriGene RNAi products in human, mouse, rat for ICAM4
    Predesigned siRNA for gene silencing in human, mouse, rat ICAM4
    Clone
    Products:             		 OriGene clones in human, mouse for ICAM4 (see all 17)
    OriGene ORF clones in mouse, rat for ICAM4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ICAM4 (NM_001544)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ICAM4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICAM4
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for ICAM4
    OriGene qSTAR qPCR primer pairs in human, mouse for ICAM4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ICAM4
      QuantiTect SYBR Green Assays in human, mouse, rat ICAM4
      QuantiFast Probe-based Assays in human, mouse, rat ICAM4

    Selected AceView cDNA sequences (see all 282):

    BQ676745 BC029364 BQ710223 BQ683708 BM473834 AU133414 AI753618 CB529024 
    CB265238 BI823891 AU133164 CF126469 X06990 AU279886 AW069267 BQ961824 
    AU104806 BQ678186 CB529704 BU170298 BG945719 NM_022377 BQ962120 AL701065 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ICAM4    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
    SP1:              -                     
    SP2:                                    


    ECgene alternative splicing isoforms for ICAM4

    Expression
    for ICAM4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ICAM4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCTGACG
    ICAM4 Expression
    About this image


    ICAM4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Proerythroblasts Hematopoietic Bone Marrow
             Bone Marrow CD105+ Cells   
             cord blood   
     
     Umbilical Cord (Extraembryonic Tissues)
             cord blood   
     
     NULL (Uncategorized)
             Embryoid bodies
    ICAM4 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    ICAM4 Protein Expression

    UniProtKB/Swiss-Prot: ICAM4_HUMAN, Q14773
    Tissue specificity: Erythrocytes

        Custom PCR Arrays for ICAM4
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    QuantiFast Probe-based Assays in human, mouse, rat ICAM4
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM4

    Orthologs
    for ICAM4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of human and mouse.

    Orthologs for ICAM4 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Icam41 , 5 intercellular adhesion molecule 4, Landsteiner-Wiener blood group less1, 5 74.33(n)1
    70.16(a)1    		   9 (7.69 cM)5
    783691  NM_023892.21  NP_076381.11 
     210293735 


    ENSEMBL Gene Tree for ICAM4 (if available)
    TreeFam Gene Tree for ICAM4 (if available)

    Paralogs
    for ICAM4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for ICAM4 gene
    ICAM52  ICAM22  ICAM12  ICAM32  

    ICAM4 for paralogs           About GeneDecksing



    Genomic Variants
    for ICAM4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    ICAM4_HUMAN, Q14773: Responsible for the Landsteiner-Wiener blood group system [MIM:111250]. The molecular basis of the
    LW(A)=LW5/LW(B)=LW7 blood group antigens is a single variation in position 100; Gln-100 corresponds to LW(A) and
    Arg-100 to LW(B)


    Selected SNPs for ICAM4 (see all 96)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs774936701,2,,4
    		C,Fnon-pathogenic110334401(+) TTACCA/GGCTGC 6 Q R mis12Minor allele frequency- G:0.00NA EU 5253
    rs357138171,2
    		C--9977811(+) CCCTTC/ATGGGT 6 /L /F mis12Minor allele frequency- A:0.00NA 4
    rs1418825371,2
    		C--9977849(+) GCAGCC/TGGGGA 6 P L mis11Minor allele frequency- T:0.00NA 3796
    rs1506540721,2
    		C,F--9977855(+) GGGGAA/GGTCAG 6 K R mis11Minor allele frequency- G:0.00NA 3956
    rs2008321531,2
    		--9977997(+) TCCCTA/CGCGCA 6 L syn10--------
    rs50303841,2
    		C,F,H--9978068(+) TGAGGG/AACAGG 3 -- int112Minor allele frequency- A:0.01NS EA NA 1278
    rs3723953381,2
    		C--9978073(+) GACAGC/GGGCTC 3 -- int10--------
    rs1998871731,2
    		C--9978078(+) GGGCTC/TGGTCC 3 -- int10--------
    rs1456824481,2
    		C--9978085(+) GTCCCA/GGCTGG 3 -- int10--------
    rs343851351,2
    		C,F,H--9978110(+) GCTGGA/CAGAGG 3 -- int16Minor allele frequency- C:0.01NS NA 500

    HapMap Linkage Disequilibrium report for ICAM4 (10397643 - 10399198 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ICAM4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911030CNV Loss21882294
    nsv911029CNV Loss21882294
    dgv3726n71CNV Loss21882294
    dgv3725n71CNV Loss21882294
    nsv911033CNV Gain21882294
    nsv911037CNV Gain21882294

    Human Gene Mutation Database (HGMD): ICAM4
    Locus Specific Mutation Databases (LSDB): ICAM4

    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ICAM4
    DNA2.0 Custom Variant and Variant Library Synthesis for ICAM4

    Disorders / Diseases
    for ICAM4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 614088   
    OMIM disorders: 111250  
    9 diseases for ICAM4:    
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    sickle cell disease    childhood leukemia    multiple myeloma    hepatitis c virus
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    ICAM4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Genetic Association Database (GAD): ICAM4
    Human Genome Epidemiology (HuGE) Navigator: ICAM4 (16 documents)

    Export disorders for ICAM4 gene to outside databases

    Publications
    for ICAM4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ICAM4 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with ICAM4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the gene encoding the human LW blood group protein in LW+ and LW- phenotypes. (PubMed id 8639917)1, 2, 3, 9 Hermand P.... Bailly P. (Blood 1996)
    2. The LW blood group glycoprotein is homologous to intercellular adhesion molecules. (PubMed id 8202485)1, 2, 9 Bailly P.... Cartron J.-P. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    3. Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci. (PubMed id 21533024)1, 4 ParAc G....Chasman D.I. (PLoS Genet. 2011)
    4. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (BMC Genet. 2010)
    5. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    6. Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels. (PubMed id 20167578)1, 4 Barbalic M....Benjamin E.J. (Hum. Mol. Genet. 2010)
    7. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    8. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    9. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    10. Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: a Go-DARTS study. (PubMed id 20622166)1, 4 Palmer C.N....Pola R. (Diabetes 2010)

    External Searches for ICAM4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing ICAM4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3386 HGNC: 5347 AceView: ICAM1andICAM4 Ensembl:ENSG00000105371 euGenes: HUgn3386
    ECgene: ICAM4 H-InvDB: ICAM4

    Other Databases showing ICAM4 gene

    (According to HUGE)
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    Specialized Databases showing ICAM4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ICAM4 Pharmacogenomics, SNPs, Pathways
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=lw
    SeattleSNPshttp://pga.gs.washington.edu/data/icam4/

    Intellectual Property
    for ICAM4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    TryGeneCards Plus    		Patent Information for ICAM4 gene:
    Search GeneIP for patents involving ICAM4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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