Aliases for ICAM4 Gene
Aliases for ICAM4 Gene
- Intercellular Adhesion Molecule 4 (Landsteiner-Wiener Blood Group) 2 3 5
- Intercellular Adhesion Molecule 4 (LW Blood Group) 2 3
- Landsteiner-Wiener Blood Group Glycoprotein 3 4
- CD242 Antigen 3 4
- LW 3 4
- Intercellular Adhesion Molecule 4, Landsteiner-Wiener Blood Group 2
- Landsteiner-Wiener Blood Group Antigen A 3
External Ids for ICAM4 Gene
- HGNC: 5347
- Entrez Gene: 3386
- Ensembl: ENSG00000105371
- OMIM: 614088
- UniProtKB: Q14773
Previous HGNC Symbols for ICAM4 Gene
- LW
Previous GeneCards Identifiers for ICAM4 Gene
- GC19P010519
- GC19P010620
- GC19P010242
- GC19P010258
- GC19P010397
- GC19P009977
Summaries for ICAM4 Gene
-
This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for ICAM4 Gene
ICAM4 (Intercellular Adhesion Molecule 4 (Landsteiner-Wiener Blood Group)) is a Protein Coding gene. Diseases associated with ICAM4 include Blood Group System, Landsteiner-Wiener. Among its related pathways are Innate Immune System and ECM-receptor interaction. Gene Ontology (GO) annotations related to this gene include integrin binding. An important paralog of this gene is ICAM5.
UniProtKB/Swiss-Prot for ICAM4 Gene
-
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICAM4 Gene
Genomics for ICAM4 Gene
GeneHancer (GH) Regulatory Elements for ICAM4 Gene
- Top Transcription factor binding sites by QIAGEN in the ICAM4 gene promoter:
Regulatory Element Products
Genomic Locations for ICAM4 Gene
- chr19:10,286,967-10,288,584
- (GRCh38/hg38)
- Size:
- 1,618 bases
- Orientation:
- Plus strand
- chr19:10,397,643-10,399,198
- (GRCh37/hg19)
Genomic View for ICAM4 Gene
- Cytogenetic band:
-
- 19p13.2 by Ensembl
- 19p13.2 by Entrez Gene
- 19p13.2 by HGNC


RefSeq DNA sequence for ICAM4 Gene
Proteins for ICAM4 Gene
-
Protein details for ICAM4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14773-ICAM4_HUMAN
- Recommended name:
- Intercellular adhesion molecule 4
- Protein Accession:
- Q14773
- A0M8X2
- Q14771
- Q14772
- Q16375
- Q9BWR0
Protein attributes for ICAM4 Gene
- Size:
- 271 amino acids
- Molecular mass:
- 29265 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for ICAM4 Gene
- N- and O-glycosylated.
- Glycosylation at isoforms=3, 268, isoforms=3, 278, posLast=190190, and posLast=223223
Other Protein References for ICAM4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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Quality Products:
No data available for DME Specific Peptides for ICAM4 Gene
Domains & Families for ICAM4 Gene
Gene Families for ICAM4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Blood group antigen proteins
- CD markers
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for ICAM4 Gene
Suggested Antigen Peptide Sequences for ICAM4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q14773- Family:
-
- Belongs to the immunoglobulin superfamily. ICAM family.
Function for ICAM4 Gene
Molecular function for ICAM4 Gene
- GENATLAS Biochemistry:
- adhesion molecule,intercellular 4
- UniProtKB/Swiss-Prot Function:
- ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.
Phenotypes From GWAS Catalog for ICAM4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005178 | integrin binding | TAS | 8566017 |
Phenotypes for ICAM4 Gene
- MGI mutant phenotypes for ICAM4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ICAM4:
Animal Models for ICAM4 Gene
- MGI Knock Outs for ICAM4:
-
- Icam4 tm1Jach
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miRNA for ICAM4 Gene
- miRTarBase miRNAs that target ICAM4
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-
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
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- Yeast expression
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ICAM4 Gene
Localization for ICAM4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ICAM4 Gene
- Isoform Long: Cell membrane; Single-pass type I membrane protein.
- Isoform Short: Secreted.
- Cell membrane; Single-pass type I membrane protein.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | IBA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | TAS | 6431896 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ICAM4 Gene
Pathways & Interactions for ICAM4 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MAPK-Erk Pathway |
.38
|
|
2 | Class I MHC mediated antigen processing and presentation | ||
3 | Degradation of the extracellular matrix | ||
4 | Innate Immune System |
.61
|
|
5 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
Pathways by source for ICAM4 Gene
2 Sino Biological pathways for ICAM4 Gene
Interacting Proteins for ICAM4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007155 | cell adhesion | IBA | -- |
GO:0030198 | extracellular matrix organization | TAS | -- |
GO:0050776 | regulation of immune response | TAS | -- |
GO:0098609 | cell-cell adhesion | IEA | -- |
No data available for SIGNOR curated interactions for ICAM4 Gene
Transcripts for ICAM4 Gene
mRNA/cDNA for ICAM4 Gene
- (3) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (282) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ICAM4 Gene
CRISPR Products
-
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ICAM4
- Applied Biological Materials Clones for ICAM4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
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ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b |
---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||
SP2: |
Expression for ICAM4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
- Erythroblasts Hematopoietic Bone Marrow
- Bone Marrow CD105+ Cells
- cord blood
- Umbilical Cord (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for ICAM4 Gene
NURSA nuclear receptor signaling pathways regulating expression of ICAM4 Gene:
ICAM4SOURCE GeneReport for Unigene cluster for ICAM4 Gene:
Hs.706750mRNA Expression by UniProt/SwissProt for ICAM4 Gene:
Q14773-ICAM4_HUMANEvidence on tissue expression from TISSUES for ICAM4 Gene
- Lung(4.1)
Primer Products
-
OriGene qPCR primer pairs for ICAM4
-
OriGene qPCR primer pairs and template standards for ICAM4
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ICAM4 Gene
Orthologs for ICAM4 Gene
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ICAM4 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | ICAM4 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | ICAM4 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Icam4 33 |
|
||
mouse (Mus musculus) |
Mammalia | Icam4 33 16 34 |
|
- Species where no ortholog for ICAM4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for ICAM4 Gene
Variants for ICAM4 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for ICAM4 Gene
- ICAM4_HUMAN-Q14773
- Responsible for the Landsteiner-Wiener blood group system [MIM:111250]. The molecular basis of the LW(A)=LW5/LW(B)=LW7 blood group antigens is a single variation in position 100; Gln-100 corresponds to LW(A) and Arg-100 to LW(B).
SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs77493670 | affects, Landsteiner-Wiener phenotype | 10,287,311(+) | A/G | coding_sequence_variant, missense_variant | |
rs1000675984 | -- | 10,285,576(+) | G/A/C | upstream_transcript_variant | |
rs1001130557 | -- | 10,285,254(+) | C/T | upstream_transcript_variant | |
rs1002288516 | -- | 10,285,542(+) | T/C | upstream_transcript_variant | |
rs1002582178 | -- | 10,285,907(+) | C/T | upstream_transcript_variant |
Additional Variant Information for ICAM4 Gene
- Human Gene Mutation Database (HGMD)
- ICAM4
- Blood Group Antigen Gene Mutation Database (BGMUT)
- Blood Group System
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ICAM4
No data available for Structural Variations from Database of Genomic Variants (DGV) for ICAM4 Gene
Disorders for ICAM4 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
blood group system, landsteiner-wiener |
|
|
Additional Disease Information for ICAM4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for ICAM4 Gene
Publications for ICAM4 Gene
- Characterization of the gene encoding the human LW blood group protein in LW+ and LW- phenotypes. (PMID: 8639917) Hermand P … Bailly P (Blood 1996) 2 3 4 22 58
- The LW blood group glycoprotein is homologous to intercellular adhesion molecules. (PMID: 8202485) Bailly P … Cartron JP (Proceedings of the National Academy of Sciences of the United States of America 1994) 3 4 22 58
- Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci. (PMID: 21533024) Paré G … Chasman DI (PLoS genetics 2011) 3 44 58
- Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 44 58
- Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
Products for ICAM4 Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ICAM4
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Sources for ICAM4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
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