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GIFtS

ICAM4 Gene

protein-coding   GIFtS: 60
GCID: GC19P010397

Intercellular Adhesion Molecule 4 (Landsteiner-Wiener Blood...

(Previous names: intercellular adhesion molecule 4, Landsteiner-Wiener blood...)
(Previous symbol: LW)
  7 related diseases
at
MalaCards
 

Aliases
for ICAM4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Intercellular Adhesion Molecule 4 (Landsteiner-Wiener Blood Group)1 2     Intercellular Adhesion Molecule 4, Landsteiner-Wiener Blood Group1
LW1 2 3     Landsteiner-Wiener Blood Group1
Intercellular Adhesion Molecule 4 (LW Blood Group)1 2     CD2422
CD242 Antigen2 3     Intercellular Adhesion Molecule 42
Landsteiner-Wiener Blood Group Glycoprotein2 3     Landsteiner-Wiener Blood Group Antigen A2
LW Blood Group Protein2 3     ICAM-43

External Ids:    HGNC: 53471   Entrez Gene: 33862   Ensembl: ENSG000001053717   OMIM: 6140885   UniProtKB: Q147733   

Export aliases for ICAM4 gene to outside databases

Previous GC identifers: GC19P010519 GC19P010620 GC19P010242 GC19P010258 GC19P009977


Summaries
for ICAM4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ICAM4 Gene:
This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig)
superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM
protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of
the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100

GeneCards Summary for ICAM4 Gene: 
ICAM4 (intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)) is a protein-coding gene. Diseases associated with ICAM4 include sickle cell disease, and multiple myeloma, and among its related super-pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include integrin binding. An important paralog of this gene is ICAM5.

UniProtKB/Swiss-Prot: ICAM4_HUMAN, Q14773
Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a
ligand for alpha-4/beta-1 and alpha-V integrins




Genomic Views
for ICAM4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ICAM4 gene promoter:
         GR   STAT1   AP-2alpha isoform 3   AP-2alpha isoform 2   STAT1alpha   AP-2alpha isoform 4   GR-alpha   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ICAM4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ICAM4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ICAM4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

ICAM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ICAM4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P010397:  view genomic region     (about GC identifiers)

Start:
 10,397,643 bp from pter      End:
 10,399,198 bp from pter
Size:
 1,556 bases      Orientation:
 plus strand

Proteins
for ICAM4 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: ICAM4_HUMAN, Q14773 (See protein sequence)
Recommended Name: Intercellular adhesion molecule 4 precursor  
Size: 271 amino acids; 29265 Da
Subcellular location: Isoform Long: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform Short: Secreted
Secondary accessions: A0M8X2 Q14771 Q14772 Q16375 Q9BWR0
Alternative splicing: 3 isoforms:  Q14773-1   Q14773-2   Q14773-3   

Explore the universe of human proteins at neXtProt for ICAM4: NX_Q14773

Explore proteomics data for ICAM4 at MOPED 

Post-translational modifications:

  • UniProtKB: N- and O-glycosylated
  • View neXtProt modification sites for NX_Q14773

    • ICAM4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ICAM4 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001034221.1  NP_001535.1  NP_071772.1  

    ENSEMBL proteins: 
     ENSP00000370147   ENSP00000342114   ENSP00000377320  
    Reactome Protein details: Q14773
    Human Recombinant Protein Products for ICAM4: 
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    OriGene Protein Over-expression Lysate for ICAM4
    OriGene MassSpec for ICAM4 
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    GenScript Custom Purified and Recombinant Proteins Services for ICAM4
    Novus Biologicals ICAM4 Proteins
    Novus Biologicals ICAM4 Lysates
    Sino Biological Recombinant Protein for ICAM4
    Sino Biological Cell Lysate for ICAM4 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ICAM4 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    ICAM4 for ontologies           About GeneDecksing



    ICAM4 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for ICAM4 

    Assay Products for ICAM4: 
    Browse Kits and Assays available from EMD Millipore
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    Protein Domains /
    Families
    for ICAM4 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    CD: CD molecules
    bloodgroup: Blood group antigens
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    3 InterPro protein domains:
     IPR013768 ICAM_N
     IPR013783 Ig-like_fold
     IPR003987 ICAM_VCAM_N

    Graphical View of Domain Structure for InterPro Entry Q14773

    ProtoNet protein and cluster: Q14773

    2 Blocks protein domains:
    IPB003987 Intercellular adhesion molecule/vascular cell adhesion molecule-1 signature
    IPB013768 Intercellular adhesion molecule


    UniProtKB/Swiss-Prot: ICAM4_HUMAN, Q14773
    Similarity: Belongs to the immunoglobulin superfamily. ICAM family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    ICAM4 for domains           About GeneDecksing


    Function
    for ICAM4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ICAM4_HUMAN, Q14773
    Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a
    ligand for alpha-4/beta-1 and alpha-V integrins

         Genatlas biochemistry entry for ICAM4:
    adhesion molecule,intercellular 4

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding TAS8566017
         
    ICAM4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ICAM4:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Icam4):
     hematopoietic system 

    ICAM4 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Icam4tm1Jach for ICAM4
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ICAM4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ICAM4

    miRNA
    Products:        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ICAM4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ICAM4
    SwitchGear 3'UTR luciferase reporter plasmid: ICAM4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ICAM4
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    Sirion Biotech Custom design and validation of potent shRNA sequences against ICAM4

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of ICAM4
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    Clone
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    OriGene clones in human, mouse for ICAM4 (see all 18)
    OriGene ORF clones in mouse, rat for ICAM4
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    GenScript: all cDNA clones in your preferred vector (see all 3): ICAM4 (NM_001544)
    Sino Biological Human cDNA Clone for ICAM4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ICAM4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICAM4

    Cell Line
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    Search LifeMap BioReagents cell lines for ICAM4
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                         Customized inducible knockdown cell line services for ICAM4
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM4


    Pathways & Interactions
    for ICAM4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ICAM4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Immune System
    		Immune System0.56
    		Adaptive Immune System0.56
    2Signaling by GPCR
    		Signal Transduction0.55
    3Non-integrin membrane-ECM interactions
    		Integrin cell surface interactions0.32
    4Classical antibody-mediated complement activation
    		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5        Reactome Pathways for ICAM4
        Integrin cell surface interactions
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Signal Transduction
    Adaptive Immune System
    Immune System



    ICAM4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ICAM4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/10 Interacting proteins for ICAM4 (Q147733 ENSP000003421144) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGAVP067563, ENSP000002610234I2D: score=1 STRING: ENSP00000261023
    ITGB2P051073, ENSP000003032424I2D: score=1 STRING: ENSP00000303242
    RHAGQ020943, ENSP000003602174I2D: score=1 STRING: ENSP00000360217
    ITGALP207013, ENSP000003492524I2D: score=1 STRING: ENSP00000349252
    ITGA4P136123, ENSP000003802274I2D: score=1 STRING: ENSP00000380227
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016337cell-cell adhesion IEA--
    GO:0050776regulation of immune response TAS--

    ICAM4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ICAM4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ICAM4

    Search CenterWatch for drugs/clinical trials and news about ICAM4

    Transcripts
    for ICAM4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ICAM4 gene (3 alternative transcripts): 
    NM_001039132.2  NM_001544.4  NM_022377.3  

    Unigene Cluster for ICAM4:

    Intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
    Hs.706750  [show with all ESTs]
    Unigene Representative Sequence: NM_022377
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380770(uc002mns.2) ENST00000340992(uc002mnr.2) ENST00000393717(uc002mnt.2)

    miRNA
    Products:         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ICAM4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ICAM4
    SwitchGear 3'UTR luciferase reporter plasmid: ICAM4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ICAM4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ICAM4
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    Clone
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    OriGene ORF clones in mouse, rat for ICAM4
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    GenScript: all cDNA clones in your preferred vector (see all 3): ICAM4 (NM_001544)
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    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ICAM4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ICAM4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ICAM4

    Additional mRNA sequence: 

    BC000046.2 BC029364.1 BT009816.1 L27670.1 L27671.1 

    3 DOTS entries:

    DT.405584  DT.92418895  DT.102822076 

    24/282 AceView cDNA sequences (see all 282):

    BM473834 CB138808 BP351585 CB529704 CB265238 BI772468 BC000046 BF431004 
    CA309669 AA306799 BQ676745 BI868876 NM_001544 BC015969 BX360248 AI753027 
    BQ962120 CF126469 BG945719 BQ678437 T28374 AU133414 AU133164 AL545876 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ICAM4    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
    SP1:              -                     
    SP2:                                    


    ECgene alternative splicing isoforms for ICAM4

    Expression
    for ICAM4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ICAM4 expression in normal human tissues (normalized intensities)      ICAM4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGCTGACG
    ICAM4 Expression
    About this image


    ICAM4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Embryoid bodies (Generation and expansion of erythroid cells)
             cord blood
     
     Umbilical Cord (Extraembryonic Tissues)
             cord blood

    See ICAM4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ICAM4

    SOURCE GeneReport for Unigene cluster: Hs.706750

    UniProtKB/Swiss-Prot: ICAM4_HUMAN, Q14773
    Tissue specificity: Erythrocytes

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM4

    Orthologs
    for ICAM4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ICAM4 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Icam41 , 5 intercellular adhesion molecule 4, Landsteiner-Wiener blood group less1, 5 74.27(n)1
    70(a)1    		   9 (7.69 cM)5
    783691  NM_023892.21  NP_076381.11 
     210293735 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 Uncharacterized protein
    		 4(a)
    		 possible ortholog
    		 GL343233.1(1353200-1357090)


    ENSEMBL Gene Tree for ICAM4 (if available)
    TreeFam Gene Tree for ICAM4 (if available)

    Paralogs
    for ICAM4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ICAM4 gene
    ICAM52  ICAM22  ICAM12  ICAM32  

    ICAM4 for paralogs           About GeneDecksing



    Genomic Variants
    for ICAM4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: ICAM4_HUMAN, Q14773
    Polymorphism: Responsible for the Landsteiner-Wiener blood group system [MIM:111250]. The molecular basis of the
    LW(A)=LW5/LW(B)=LW7 blood group antigens is a single variation in position 100; Gln-100 corresponds to LW(A) and
    Arg-100 to LW(B)


    10/96 SNPs in ICAM4 are shown (see all 96)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs774936701,2,4
    		C,Fnon-pathogenic110334401(+) TTACCA/GGCTGC 6 Q R mis12Minor allele frequency- G:0.00NA EU 5253
    rs357138171,2
    		C--9977811(+) CCCTTC/ATGGGT 6 /L /F mis12Minor allele frequency- A:0.00NA 4
    rs1418825371,2
    		C--9977849(+) GCAGCC/TGGGGA 6 P L mis11Minor allele frequency- T:0.00NA 3796
    rs1506540721,2
    		C,F--9977855(+) GGGGAA/GGTCAG 6 K R mis11Minor allele frequency- G:0.00NA 3956
    rs2008321531,2
    		--9977997(+) TCCCTA/CGCGCA 6 L syn10--------
    rs50303841,2
    		C,F,H--9978068(+) TGAGGG/AACAGG 3 -- int112Minor allele frequency- A:0.01NS EA NA 1278
    rs3723953381,2
    		C--9978073(+) GACAGC/GGGCTC 3 -- int10--------
    rs1998871731,2
    		C--9978078(+) GGGCTC/TGGTCC 3 -- int10--------
    rs1456824481,2
    		C--9978085(+) GTCCCA/GGCTGG 3 -- int10--------
    rs343851351,2
    		C,F,H--9978110(+) GCTGGA/CAGAGG 3 -- int16Minor allele frequency- C:0.01NS NA 500

    HapMap Linkage Disequilibrium report for ICAM4 (10397643 - 10399198 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ICAM4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911030CNV Loss21882294
    nsv911029CNV Loss21882294
    dgv3726n71CNV Loss21882294
    dgv3725n71CNV Loss21882294
    nsv911033CNV Gain21882294
    nsv911037CNV Gain21882294


    Human Gene Mutation Database (HGMD): ICAM4

    Locus Specific Mutation Databases (LSDB): ICAM4
    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system
    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for ICAM4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ICAM4 for disorders           About GeneDecksing

    OMIM gene information: 614088    OMIM disorders: --

    7 diseases for ICAM4:    About MalaCards
    sickle cell disease    multiple myeloma    meningioma    myeloma
    hepatitis c    hepatitis    leukemia

    Genetic Association Database (GAD): ICAM4
    Human Genome Epidemiology (HuGE) Navigator: ICAM4 (16 documents)

    Export disorders for ICAM4 gene to outside databases

    Publications
    for ICAM4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ICAM4 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with ICAM4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the gene encoding the human LW blood group protein in LW+ and LW- phenotypes. (PubMed id 8639917)1, 2, 3, 9 Hermand P.... Bailly P. (1996)
    2. The LW blood group glycoprotein is homologous to intercellular adhesion molecules. (PubMed id 8202485)1, 2, 9 Bailly P.... Cartron J.-P. (1994)
    3. Genome-wide association analysis of soluble ICAM-1 co ncentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 l oci. (PubMed id 21533024)1, 4 ParAc G....Chasman D.I. (2011)
    4. Identification of type 2 diabetes-associated combinat ion of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (2010)
    5. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    6. Large-scale genomic studies reveal central role of AB O in sP-selectin and sICAM-1 levels. (PubMed id 20167578)1, 4 Barbalic M....Benjamin E.J. (2010)
    7. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    8. Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (2010)
    9. Common single nucleotide polymorphisms in immunoregul atory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (2010)
    10. Combined effect of inflammatory gene polymorphisms an d the risk of ischemic stroke in a prospective cohort of subjects with type 2 d iabetes: a Go-DARTS study. (PubMed id 20622166)1, 4 Palmer C.N....Pola R. (2010)

    External Searches for ICAM4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
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    Genome Databases showing ICAM4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3386 HGNC: 5347 AceView: ICAM1andICAM4 Ensembl:ENSG00000105371 euGenes: HUgn3386
    ECgene: ICAM4 H-InvDB: ICAM4

    Other Databases showing ICAM4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ICAM4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ICAM4 Pharmacogenomics, SNPs, Pathways
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=lw
    SeattleSNPshttp://pga.gs.washington.edu/data/icam4/

    Intellectual Property
    for ICAM4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ICAM4 gene:
    Search GeneIP for patents involving ICAM4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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