Aliases for ICAM4 Gene
External Ids for ICAM4 Gene
Previous HGNC Symbols for ICAM4 Gene
Previous GeneCards Identifiers for ICAM4 Gene
This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for ICAM4 Gene
ICAM4 (Intercellular Adhesion Molecule 4 (Landsteiner-Wiener Blood Group)) is a Protein Coding gene. Diseases associated with ICAM4 include childhood leukemia. Among its related pathways are Class I MHC mediated antigen processing and presentation and Degradation of the extracellular matrix. GO annotations related to this gene include integrin binding. An important paralog of this gene is ICAM1.
UniProtKB/Swiss-Prot for ICAM4 Gene
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.