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Aliases for ICAM4 Gene

Aliases for ICAM4 Gene

  • Intercellular Adhesion Molecule 4 (Landsteiner-Wiener Blood Group) 2 3
  • LW 3 4 6
  • Intercellular Adhesion Molecule 4 (LW Blood Group) 2 3
  • Landsteiner-Wiener Blood Group Glycoprotein 3 4
  • LW Blood Group Protein 3 4
  • CD242 Antigen 3 4
  • CD242 3 6
  • Intercellular Adhesion Molecule 4, Landsteiner-Wiener Blood Group 2
  • Intercellular Adhesion Molecule 4 Isoform 3 Anitgen LWa 3
  • Landsteiner-Wiener Blood Group Antigen A 3
  • Intercellular Adhesion Molecule 4 3
  • Landsteiner-Wiener Blood Group 2
  • ICAM-4 4

External Ids for ICAM4 Gene

Previous HGNC Symbols for ICAM4 Gene

  • LW

Previous GeneCards Identifiers for ICAM4 Gene

  • GC19P010519
  • GC19P010620
  • GC19P010242
  • GC19P010258
  • GC19P010397
  • GC19P009977

Summaries for ICAM4 Gene

Entrez Gene Summary for ICAM4 Gene

  • This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for ICAM4 Gene

ICAM4 (Intercellular Adhesion Molecule 4 (Landsteiner-Wiener Blood Group)) is a Protein Coding gene. Diseases associated with ICAM4 include childhood leukemia. Among its related pathways are Class I MHC mediated antigen processing and presentation and Degradation of the extracellular matrix. GO annotations related to this gene include integrin binding. An important paralog of this gene is ICAM1.

UniProtKB/Swiss-Prot for ICAM4 Gene

  • ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICAM4 Gene

Genomics for ICAM4 Gene

Genomic Location for ICAM4 Gene

10,286,967 bp from pter
10,288,584 bp from pter
1,618 bases
Plus strand

Genomic View for ICAM4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ICAM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICAM4 Gene

Proteins for ICAM4 Gene

  • Protein details for ICAM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Intercellular adhesion molecule 4
    Protein Accession:
    Secondary Accessions:
    • A0M8X2
    • Q14771
    • Q14772
    • Q16375
    • Q9BWR0

    Protein attributes for ICAM4 Gene

    271 amino acids
    Molecular mass:
    29265 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ICAM4 Gene


neXtProt entry for ICAM4 Gene

Proteomics data for ICAM4 Gene at MOPED

Post-translational modifications for ICAM4 Gene

Other Protein References for ICAM4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ICAM4 Gene

Domains for ICAM4 Gene

Gene Families for ICAM4 Gene

  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • bloodgroup :Blood group antigens

Suggested Antigen Peptide Sequences for ICAM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q14773
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. ICAM family.
genes like me logo Genes that share domains with ICAM4: view

Function for ICAM4 Gene

Molecular function for ICAM4 Gene

GENATLAS Biochemistry: adhesion molecule,intercellular 4
UniProtKB/Swiss-Prot Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins.

Gene Ontology (GO) - Molecular Function for ICAM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding TAS 8566017
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ICAM4: view

Phenotypes for ICAM4 Gene

MGI mutant phenotypes for ICAM4:
inferred from 1 alleles
GenomeRNAi human phenotypes for ICAM4:
genes like me logo Genes that share phenotypes with ICAM4: view

Animal Models for ICAM4 Gene

MGI Knock Outs for ICAM4:

miRNA for ICAM4 Gene

miRTarBase miRNAs that target ICAM4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ICAM4 Gene

Localization for ICAM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICAM4 Gene

Isoform Long: Cell membrane; Single-pass type I membrane protein.
Isoform Short: Secreted.

Subcellular locations from

Jensen Localization Image for ICAM4 Gene COMPARTMENTS Subcellular localization image for ICAM4 gene
Compartment Confidence
extracellular 5
plasma membrane 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ICAM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane TAS 6431896
genes like me logo Genes that share ontologies with ICAM4: view

Pathways for ICAM4 Gene

genes like me logo Genes that share pathways with ICAM4: view

Gene Ontology (GO) - Biological Process for ICAM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IBA --
GO:0016337 single organismal cell-cell adhesion IEA --
GO:0030198 extracellular matrix organization TAS --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with ICAM4: view

Transcripts for ICAM4 Gene

Unigene Clusters for ICAM4 Gene

Intercellular adhesion molecule 4 (Landsteiner-Wiener blood group):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ICAM4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1: -

Relevant External Links for ICAM4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ICAM4 Gene

mRNA expression in normal human tissues for ICAM4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ICAM4 Gene

This gene is overexpressed in Whole Blood (15.1) and Lung (9.4).

SOURCE GeneReport for Unigene cluster for ICAM4 Gene Hs.706750

mRNA Expression by UniProt/SwissProt for ICAM4 Gene

Tissue specificity: Erythrocytes
genes like me logo Genes that share expressions with ICAM4: view

No data available for Protein expression for ICAM4 Gene

Orthologs for ICAM4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ICAM4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ICAM4 35
  • 99.51 (n)
  • 99.26 (a)
ICAM4 36
  • 61 (a)
(Bos Taurus)
Mammalia ICAM4 35
  • 76.87 (n)
  • 71.55 (a)
ICAM4 36
  • 34 (a)
(Canis familiaris)
Mammalia ICAM4 35
  • 79.39 (n)
  • 72.81 (a)
ICAM4 36
  • 38 (a)
(Mus musculus)
Mammalia Icam4 35
  • 74.33 (n)
  • 70.16 (a)
Icam4 16
Icam4 36
  • 34 (a)
(Rattus norvegicus)
Mammalia Icam4 35
  • 75.21 (n)
  • 70.51 (a)
Species with no ortholog for ICAM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ICAM4 Gene

Gene Tree for ICAM4 (if available)
Gene Tree for ICAM4 (if available)

Paralogs for ICAM4 Gene

Paralogs for ICAM4 Gene

genes like me logo Genes that share paralogs with ICAM4: view

Variants for ICAM4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ICAM4 Gene

Responsible for the Landsteiner-Wiener blood group system [MIM:111250]. The molecular basis of the LW(A)=LW5/LW(B)=LW7 blood group antigens is a single variation in position 100; Gln-100 corresponds to LW(A) and Arg-100 to LW(B)

Sequence variations from dbSNP and Humsavar for ICAM4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs5030384 -- 10,287,413(+) TGAGG(A/G)ACAGG intron-variant
rs5030385 -- 10,287,932(+) CCACG(C/G)GGGTC intron-variant, utr-variant-3-prime
rs34385135 -- 10,287,455(+) GCTGG(A/C)AGAGG intron-variant
rs35165411 -- 10,287,530(+) CCTTG(C/T)CTTAG intron-variant
rs35713817 -- 10,287,156(+) CCCTT(A/C)TGGGT missense, reference

Structural Variations from Database of Genomic Variants (DGV) for ICAM4 Gene

Variant ID Type Subtype PubMed ID
nsv911029 CNV Loss 21882294
nsv911030 CNV Loss 21882294
dgv3725n71 CNV Loss 21882294
nsv911033 CNV Gain 21882294
dgv3726n71 CNV Loss 21882294
nsv911037 CNV Gain 21882294

Relevant External Links for ICAM4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group

Disorders for ICAM4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ICAM4 Gene including...

Search for ICAM4 Gene in MalaCards »

(1) OMIM Diseases for ICAM4 Gene (614088)

Relevant External Links for ICAM4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ICAM4: view

No data available for UniProtKB/Swiss-Prot for ICAM4 Gene

Publications for ICAM4 Gene

  1. Characterization of the gene encoding the human LW blood group protein in LW+ and LW- phenotypes. (PMID: 8639917) Hermand P. … Bailly P. (Blood 1996) 2 3 4 23
  2. The LW blood group glycoprotein is homologous to intercellular adhesion molecules. (PMID: 8202485) Bailly P. … Cartron J.-P. (Proc. Natl. Acad. Sci. U.S.A. 1994) 3 4 23
  3. [Polymorphism of LW blood group gene in Chinese population]. (PMID: 18549656) Su Y.Q. … Wei T.L. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008) 3 23
  4. Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women. (PMID: 18604267) ParAc G. … Ridker P.M. (PLoS Genet. 2008) 3 48
  5. Candidate gene polymorphisms for ischemic stroke. (PMID: 19729601) Matarin M. … Meschia J.F. (Stroke 2009) 3 48

Products for ICAM4 Gene

Sources for ICAM4 Gene

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