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ICAM3 Gene

protein-coding GIFtS: 66

GC19M010305

intercellular adhesion molecule 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
CD50 ^¹, ²
CDW50 ^¹, ², ⁵
CDw50 ^³
ICAM-3 ^³
ICAM-R ^¹, ², ³

Descriptions
CD50 antigen ^³
intercellular adhesion molecule 3 ^²
intercellular adhesion molecule-3 ^²

External Ids
HGNC: 5346¹
Entrez Gene: 3385²
UniProtKB: P32942³
Ensembl: ENSG00000076662⁷

Search outside databases for aliases for ICAM3 gene

Previous GC identifers: GC19M010565 GC19M010667 GC19M010289

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ICAM3:

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family.

All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type

domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and

abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the

initiation of the immune response. It functions not only as an adhesion molecule, but also as a

potent signalling molecule. [provided by RefSeq]

UniProtKB/Swiss-Prot: ICAM3_HUMAN, P32942

Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin

alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2

Gene Wiki entry for ICAM3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ICAM3 gene

Entrez Gene cytogenetic band: 19p13.3-p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.3-p13.2

ICAM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M010305: (about GC identifiers)

Start:	10,305,452 bp from pter
End:	10,311,344 bp from pter
Size:	5,893 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011295.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ICAM3_HUMAN, P32942 (See protein sequence)

Recommended Name: Intercellular adhesion molecule 3 precursor

Size: 547 amino acids; 59541 Da

Subcellular location: Membrane; Single-pass type I membrane protein

PDB structures from and Proteopedia :

1T0P (3D)

Secondary accessions: Q6PD68

Post-translational modifications:

Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine

residues¹

N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and

high-mannose chains¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002153.2

ENSEMBL proteins:

ENSP00000160262

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for ICAM3 (ICAM-3/CD50)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ICAM3)
	Human Recombinant Proteins from Abnova (ICAM3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	NAS	1448173
GO:0005887	integral to plasma membrane	TAS	8459213

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Antibodies for ICAM3:

	Invitrogen Antibodies for ICAM3
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ICAM3
	R&D Systems Antibodies for ICAM3 (ICAM-3/CD50)
	Antibodies from Abcam (ICAM3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ICAM3)
	Novus Biologicals Antibodies for ICAM3

Assays for ICAM3:

	Invitrogen Assays for ICAM3
	Millipore Kits and Assays for the Analysis of ICAM3
	R&D Systems ELISAs for ICAM3 (ICAM-3/CD50) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P32942

ProtoNet protein and cluster: P32942

4 Blocks protein families:

IPB003599 Immunoglobulin subtype

IPB003987 Intercellular adhesion molecule/vascular cell adhesion molecule-1 signature

IPB003988 Intercellular adhesion molecule (ICAM) family signature

IPB013768 Intercellular adhesion molecule

UniProtKB/Swiss-Prot: ICAM3_HUMAN, P32942

Similarity: Belongs to the immunoglobulin superfamily. ICAM family

Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ICAM3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ICAM3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002162

Applied Biosystems Silencer® siRNAs for ICAM3

Sigma-Aldrich siRNA and siRNA Panels for ICAM3

Sigma-Aldrich shRNA Panels and shRNA for ICAM3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ICAM3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002162
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002162
untagged cDNA clones in CMV expression vector (see all 2): NM_002162

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002162

UniProtKB/Swiss-Prot: ICAM3_HUMAN, P32942

Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin

alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2

Genatlas biochemistry entry for ICAM3:

adhesion molecule intercellular 3,ligand for LFA1,counterreceptor,expressed only on the leukocytes

interacting with moesin and promoting its redistribution to the uropod of T lymphocytes during

cell polarization,Ig superfamily

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005178	integrin binding	TAS	1448174

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for ICAM3 (Your Favorite Gene powered by Ingenuity)

Leukocyte Extravasation Signaling

GeneDecks ICAM3 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ICAM3

5/45 Interacting proteins for ICAM3 (P32942^{1, 2} ENSP00000160262³) via UniProtKB, MINT, and/or STRING (see all 45 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ITGAL	P20701¹, ENSP00000349252³	EBI-725421, EBI-961214 STRING (score=.999)
CLEC4M	ENSP00000316228³	STRING (score=.995)
CD209	ENSP00000315477³	STRING (score=.994)
MSN	ENSP00000353408³	STRING (score=.992)
ITGB2	ENSP00000347279³	STRING (score=.981)

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016337	cell-cell adhesion	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ICAM3
7 Novoseek chemical compound relationships for ICAM3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
n-formylmethionyl-leucylphenylalanine	39.06	2	10733515 (1), 14723618 (1)
mannose	17.35	1	15545280 (1)
fmlp	12.76	1	14723618 (1)
rantes	10.66	3	9298994 (2), 9174593 (1)
phosphatidylinositol	2.16	1	11784723 (1)
calcium	0.00	6	9672149 (3), 10688433 (2)
tyrosine	0.00	7	7520448 (5)

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2 PharmGKB drug compound relationships for ICAM3 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
mercaptopurine	PD FA GN	12704389
methotrexate	PD FA GN	12704389

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ICAM3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ICAM3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002162

Sigma-Aldrich siRNA and siRNA Panels for ICAM3

Sigma-Aldrich shRNA Panels and shRNA for ICAM3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002162

REFSEQ mRNAs for ICAM3 gene:

NM_002162.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002162

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002162
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002162
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002162

Additional cDNA sequence:

AF340060.1 AF340061.1 AK226023.1 AK301071.1 AK309643.1 AK312826.1 BC034409.1 BC040123.1

BC046121.1 BC058903.1 CR590853.1 CR594982.1 CR623746.1 S50015.1 X69711.1 X69819.1

8 DOTS entries:

DT.453621 DT.40250724 DT.100786949 DT.99993152 DT.95278145 DT.92049816 DT.92424245 DT.100786951

24/529 AceView cDNA sequences (see all 529 ):

BF724596 BM832369 BM926198 BQ011343 BQ233371 BQ548716 BQ430683 BC034409

C01301 BC058903 BI818565 BX282435 AI498122 AW205690 BQ709668 CD557260

BU859475 BM551727 BE702352 AW631239 BC037428 BX353652 BM738616 AW245043

highest scoring ESTs for ICAM3:

X69819 AL531288 AL709279 BC034409 BC040123 BC046121 BC058903 BE270839 BG258576 BG341069

Unigene Cluster for ICAM3:

Intercellular adhesion molecule 3

Hs.654563 [show with all ESTs]

Unigene Representative Sequence: BC046121

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ICAM3 (see all 6 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6	^	7a	·	7b	·	7c
SP1:							-												-
SP2:							-
SP3:							-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ICAM3

1 Ensembl transcript including schematic representation:

ENST00000160262

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ICAM3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ICAM3

¹ / ² / ³

3 probe-sets matching ICAM3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
402_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X69819	1.00	1.00	1.00	1
204949_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002162	0.60	1.00	0.82	1
204949_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ICAM3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTAGGGAGGA

SOURCE GeneReport for Unigene cluster: Hs.654563
Expression variation in blood from EXPOLDB for ICAM3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ICAM3 gene from 2 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ICAM3¹	--	intercellular adhesion molecule 3	99.51(n) 98.54(a)	494138 NM_001009167.1 NP_001009167.1
cow (Bos taurus)	ICAM3¹	--	intercellular adhesion molecule 3	72.1(n) 60.49(a)	281840 NM_174349.1 NP_776774.1

About this table Species with no ortholog for ICAM3

ENSEMBL Gene Tree for ICAM3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ICAM3 gene

ICAM5² ICAM2² ICAM1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/43 NCBI SNPs in ICAM3 are shown (see all 43 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 37)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs7258015^1,2	A,C,F,H	10310358(+)	`CTCACT/CGTACA`	1	G/R	mis¹		5	EU EA WA NA	492
	rs2304237^1,2	A,C,F,H	10307568(+)	`ACCCAT/CCCTCC`	1	G/D	mis¹ ese³		9	EA NA EU WA	2110
	rs17697947^1,2	C,F,H	10310514(+)	`GGCGAT/CTTTCT`	1	V/I	mis¹		11	NA EU EA WA	982
	rs281415^1,2	C,F	10311993(+)	`GCTGAG/TTCCCT`	1	--	ng3¹		4	NA	182
--	rs3176764^1,2	C,F	10312075(-)	`ctccaG/Acctgg`	1	--	ng3¹		1	NA	40
--	rs17000699^1,2	F	10311667(-)	`GACAGA/GATATT`	1	--	ng3¹		2	MN EA	356
--	rs17000708^1,2	F	10311934(-)	`CCCAAG/CATCTT`	1	--	ng3¹		2	MN EA	356
	rs10406010^1,2	H	10312415(+)	`TTCCAA/GGGGAA`	1	--	ng3¹		4	EU EA WA	382
	rs281414^1,2	A,C,F,H,O	10311285(+)	`ATGGTG/AGCCAT`	1	A/A	syn¹ ese³		17	MN NA EU EA WA	1584
	rs2304240^1,2	A,C,F,H	10310392(+)	`ATCTGA/GGAGCC`	1	S/S	syn¹		18	EA NA EU WA	2966

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HapMap Linkage Disequilibrium images for ICAM3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 146631

10/21 Novoseek disease relationships for ICAM3 gene (see all 21 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
immunodeficiency	37.66	8	11799181 (1), 12477827 (1), 14970226 (1), 16641270 (1) (see all 8)
inflammation	35.37	3	17701178 (1), 8579109 (1), 16792588 (1)
asthma allergic	24.76	1	11964048 (1)
colitis ulcerative	21.54	3	9471026 (1), 9473377 (1), 10931137 (1)
autoimmune response	17.47	1	7523142 (1)
dermatitis atopic	11.13	5	8547030 (2)
psoriasis	7.18	7	8547030 (2), 8721479 (1), 12854881 (1)
tumors	5.47	5	8946680 (3), 15880373 (1), 8579109 (1)
inflammatory bowel diseases	2.68	1	10931137 (1)
hiv infections	1.48	1	17530994 (1)

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1 PharmGKB disease relationship for ICAM3 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	PD FA GN	12086872 12704389

About this table

Human Genome Epidemiology Navigator: ICAM3 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/209 PubMed articles for ICAM3 gene (see all 209 ):

Cloning and characterization of a new intercellular adhesion molecule ICAM-R. (PubMed id 1448174)^{1, 2, 3, 4} Vazeux R.... Gallatin W.M. (1992)
Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes. (PubMed id 1448173)^{1, 3, 4} Fawcett J.... Simmons D.L. (1992)
Structural study of N-linked oligosaccharides of human intercellular adhesion molecule-3 (CD50). (PubMed id 11179968)^{1, 3, 4} Funatsu O....Furukawa K. (2001)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{3, 4} Liu T.... Smith R.D. (2005)
Cloning and expression of intercellular adhesion molecule 3 reveals strong homology to other immunoglobulin family counter-receptors for lymphocyte function-associated antigen 1. (PubMed id 8459213)^{3, 4} de Fougerolles A.R.... Springer T.A. (1993)
CDw50 and ICAM-3: two names for the same molecule. (PubMed id 8325327)^{3, 4} Juan M....Springer T.A. (1993)
DC-SIGN binds ICAM-3 isolated from peripheral human leukocytes through Lewis x residues. (PubMed id 17145745)^{1, 3} Bogoevska V....Wagener C. (2007)
A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting. (PubMed id 11784723)^{1, 3} Serrador J.M....Sanchez-Madrid F. (2002)
ICAM-3 activation modulates cell-cell contacts of human bone marrow endothelial cells. (PubMed id 14726630)^{1, 3} van Buul J.D....Hordijk P.L. (2004)
Increased expression of ICAM-3 is associated with radiation resistance in cervical cancer. (PubMed id 15880373)^{1, 3} Chung Y.M....Bae D.S. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3385	HGNC: 5346	AceView: ICAM3andMGC19604andRAVER1	Ensembl:ENSG00000076662	euGenes: HUgn3385
ECgene: ICAM3	H-InvDB: ICAM3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ICAM3	Genetics and Cytogenetics in Oncology and Haematology
R&D Systems' cytokine source book: ICAM-3	http://www.rndsystems.com/molecule_detail.aspx?m=1589
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_263

Licensable Technologies for ICAM3
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ICAM3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ICAM3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ICAM3		Antibodies for ICAM3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ICAM3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ICAM3)
	Antibodies (ICAM3)
	Chimera RNAi (ICAM3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (ICAM3)
	Antibodies (ICAM3)

Search OriGene for ICAM3

Search Tocris compounds for ICAM3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ICAM3

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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ICAM3 Gene at Home site.
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ICAM3 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for ICAM3

Summaries
for ICAM3

Genomic Location
for ICAM3

Proteins
for ICAM3

Protein Domains/
Families
for ICAM3

Gene Function
for ICAM3

Pathways & Interactions
for ICAM3

Drugs & Compounds
for ICAM3

Transcripts
for ICAM3

Expression
for ICAM3

Orthologs
for ICAM3

Paralogs
for ICAM3

SNPs/Variants
for ICAM3

Disorders & Mutations
for ICAM3

Medical News
for ICAM3

Publications
for ICAM3

Search for ICAM3

Genome Databases showing ICAM3

Other Databases showing ICAM3

Specialized Databases showing ICAM3

Licensable Technologies
for ICAM3

Services
for ICAM3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ICAM3 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor ICAM3

Summariesfor ICAM3

Genomic Locationfor ICAM3

Proteinsfor ICAM3

Protein Domains/Familiesfor ICAM3

Gene Functionfor ICAM3

Pathways & Interactionsfor ICAM3

Drugs & Compoundsfor ICAM3

Transcriptsfor ICAM3

Expression for ICAM3

Orthologsfor ICAM3

Paralogsfor ICAM3

SNPs/Variantsfor ICAM3

Disorders & Mutationsfor ICAM3

Medical Newsfor ICAM3

Publicationsfor ICAM3

Search for ICAM3

Genome Databases showing ICAM3

Other Databases showing ICAM3

Specialized Databases showing ICAM3

Licensable Technologiesfor ICAM3

Servicesfor ICAM3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ICAM3

Summaries
for ICAM3

Genomic Location
for ICAM3

Proteins
for ICAM3

Protein Domains/
Families
for ICAM3

Gene Function
for ICAM3

Pathways & Interactions
for ICAM3

Drugs & Compounds
for ICAM3

Transcripts
for ICAM3

Expression
for ICAM3

Orthologs
for ICAM3

Paralogs
for ICAM3

SNPs/Variants
for ICAM3

Disorders & Mutations
for ICAM3

Medical News
for ICAM3

Publications
for ICAM3

Licensable Technologies
for ICAM3

Services
for ICAM3