Aliases for ICAM3 Gene
External Ids for ICAM3 Gene
Previous GeneCards Identifiers for ICAM3 Gene
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
GeneCards Summary for ICAM3 Gene
ICAM3 (Intercellular Adhesion Molecule 3) is a Protein Coding gene. Diseases associated with ICAM3 include Relapsing-Remitting Multiple Sclerosis and Trichosporonosis. Among its related pathways are Immune System and IL-5 Signaling Pathway. GO annotations related to this gene include receptor binding and integrin binding. An important paralog of this gene is ICAM1.
UniProtKB/Swiss-Prot for ICAM3 Gene
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2.