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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ICAM3 Gene

protein-coding   GIFtS: 66
GCID: GC19M010444

Intercellular Adhesion Molecule 3

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Intercellular Adhesion Molecule 31 2     CD502
ICAM-32 3     Intercellular Adhesion Molecule-32
ICAM-R2 3     CDw503
CDW502 5     CD50 Antigen3

External Ids:    HGNC: 53461   Entrez Gene: 33852   Ensembl: ENSG000000766627   OMIM: 1466315   UniProtKB: P329423   

Export aliases for ICAM3 gene to outside databases

Previous GC identifers: GC19M010565 GC19M010667 GC19M010289 GC19M010305 GC19M010024


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ICAM3 Gene:
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM
proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the
leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and
may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an
adhesion molecule, but also as a potent signalling molecule. (provided by RefSeq, Jul 2008)

GeneCards Summary for ICAM3 Gene: 
ICAM3 (intercellular adhesion molecule 3) is a protein-coding gene. Diseases associated with ICAM3 include colon carcinoma in situ, and tick-borne encephalitis, and among its related super-pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include integrin binding and receptor binding. An important paralog of this gene is ICAM4.

UniProtKB/Swiss-Prot: ICAM3_HUMAN, P32942
Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is
also a ligand for integrin alpha-D/beta-2

Gene Wiki entry for ICAM3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ICAM3 gene promoter:
         Pax-3   Sp1   Bach2   Tal-1beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidICAM3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ICAM3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ICAM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3-p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.3-p13.2

ICAM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ICAM3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M010444:  view genomic region     (about GC identifiers)

Start:
10,444,452 bp from pter      End:
10,450,499 bp from pter
Size:
6,048 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ICAM3_HUMAN, P32942 (See protein sequence)
Recommended Name: Intercellular adhesion molecule 3 precursor  
Size: 547 amino acids; 59541 Da
Subcellular location: Membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for ICAM3:
1T0P (3D)    
Secondary accessions: Q6PD68

Explore the universe of human proteins at neXtProt for ICAM3: NX_P32942

Explore proteomics data for ICAM3 at MOPED 

Post-translational modifications:

  • UniProtKB: Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues
  • UniProtKB: N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose
    chains
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P32942

  • ICAM3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ICAM3 Protein Expression
    REFSEQ proteins: NP_002153.2  
    ENSEMBL proteins: 
     ENSP00000160262   ENSP00000468230   ENSP00000468333   ENSP00000467232   ENSP00000466501  
     ENSP00000467770   ENSP00000466081   ENSP00000468282  
    Reactome Protein details: P32942
    Human Recombinant Protein Products for ICAM3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ICAM3 (ICAM-3/CD50)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ICAM3
    OriGene Protein Over-expression Lysate for ICAM3
    OriGene MassSpec for ICAM3 
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    GenScript Custom Purified and Recombinant Proteins Services for ICAM3
    Novus Biologicals ICAM3 Proteins
    Novus Biologicals ICAM3 Lysate
    Sino Biological Recombinant Protein for ICAM3
    Sino Biological Cell Lysate for ICAM3 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ICAM3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8459213
    GO:0016020membrane ----

    ICAM3 for ontologies           About GeneDecksing



    ICAM3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ICAM3
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    Abcam antibodies for ICAM3
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    LSBio Antibodies in human, mouse, rat for ICAM3 

    Assay Products for ICAM3: 
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    Cloud-Clone Corp. ELISAs for ICAM3 
    Cloud-Clone Corp. CLIAs for ICAM3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    5/6 InterPro protein domains (see all 6):
     IPR003988 ICAM
     IPR013768 ICAM_N
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P32942

    ProtoNet protein and cluster: P32942

    4 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB003987 Intercellular adhesion molecule/vascular cell adhesion molecule-1 signature
    IPB003988 Intercellular adhesion molecule (ICAM) family signature
    IPB013768 Intercellular adhesion molecule


    UniProtKB/Swiss-Prot: ICAM3_HUMAN, P32942
    Similarity: Belongs to the immunoglobulin superfamily. ICAM family
    Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains


    ICAM3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ICAM3_HUMAN, P32942
    Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is
    also a ligand for integrin alpha-D/beta-2

         Genatlas biochemistry entry for ICAM3:
    adhesion molecule intercellular 3,ligand for LFA1,counterreceptor,expressed only on the leukocytes interacting
    with moesin and promoting its redistribution to the uropod of T lymphocytes during cell polarization,Ig
    superfamily

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS8459213
    GO:0005178integrin binding IPI1448173
    GO:0005515protein binding IPI12082081
         
    ICAM3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ICAM3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ICAM3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ICAM3 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ICAM3 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Immune System
    Immune System0.56
    Adaptive Immune System0.56
    2Signaling by GPCR
    Signal Transduction0.55
    3Immune response Role of integrins in NK cells cytotoxicity
    Immune response Role of integrins in NK cells cytotoxicity1.00
    4Non-integrin membrane-ECM interactions
    Integrin cell surface interactions0.32
    5Classical antibody-mediated complement activation
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell0.30

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ICAM3
        Immune response Role of integrins in NK cells cytotoxicity


    1 GeneGo (Thomson Reuters) Pathway for ICAM3
        Immune response Role of integrins in NK cells cytotoxicity

    1 BioSystems Pathway for ICAM3
        IL-5 Signaling Pathway


    5        Reactome Pathways for ICAM3
        Integrin cell surface interactions
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Signal Transduction
    Adaptive Immune System
    Immune System


    1         Kegg Pathway  (Kegg details for ICAM3):
        Cell adhesion molecules (CAMs)


    ICAM3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ICAM3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for ICAM3 (P329422, 3 ENSP000001602624) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZBTB16Q055162, 3, ENSP000003381574MINT-63670 I2D: score=4 STRING: ENSP00000338157
    EZRP153113, ENSP000003389344I2D: score=3 STRING: ENSP00000338934
    ITGB2P051073, ENSP000003032424I2D: score=2 STRING: ENSP00000303242
    PRKCQQ047593, ENSP000002631254I2D: score=2 STRING: ENSP00000263125
    CD209Q9NNX63, ENSP000003154774I2D: score=1 STRING: ENSP00000315477
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016337cell-cell adhesion IEA--
    GO:0050776regulation of immune response TAS--

    ICAM3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ICAM3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ICAM3

    10 Novoseek inferred chemical compound relationships for ICAM3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-formylmethionyl-leucylphenylalanine 38.6 2 10733515 (1), 14723618 (1)
    polysaccharide 16.9 2 15545280 (1), 17145745 (1)
    mannose 16 1 15545280 (1)
    fmlp 12.1 1 14723618 (1)
    rantes 9.47 3 9298994 (2), 9174593 (1)
    phosphatidylinositol 0.949 1 11784723 (1)
    calcium 0 6 9672149 (3), 10688433 (2)
    tyrosine 0 7 7520448 (5)
    carbohydrates 0 1 12234361 (1)
    dexamethasone 0 2 10688433 (1), 8730134 (1)

    Search CenterWatch for drugs/clinical trials and news about ICAM3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ICAM3 gene: 
    NM_002162.3  

    Unigene Cluster for ICAM3:

    Intercellular adhesion molecule 3
    Hs.654563  [show with all ESTs]
    Unigene Representative Sequence: BC046121
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589900 ENST00000587992 ENST00000160262(uc002mob.2 uc010dxd.1 uc010xlf.1)
    ENST00000592945 ENST00000589261 ENST00000592439 ENST00000585439 ENST00000590569
    ENST00000589249 ENST00000589580
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICAM3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ICAM3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ICAM3

    Additional mRNA sequence: 

    AF340060.1 AF340061.1 AK226023.1 AK301071.1 AK309643.1 AK312826.1 BC034409.1 BC040123.1 
    BC046121.1 BC058903.1 S50015.1 X69711.1 X69819.1 

    7 DOTS entries:

    DT.453621  DT.40250724  DT.100786949  DT.99993152  DT.92049816  DT.92424245  DT.100786951 

    24/529 AceView cDNA sequences (see all 529):

    BQ062308 CA424713 BE395527 BQ086373 BM310518 BE257181 BX345508 AW237209 
    BQ446829 BX353652 BM726266 AA354247 BI255037 BM460975 BG257988 BM738616 
    BC034409 BF724596 AI289404 AI298330 N95446 BC037428 BC044225 CR594982 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ICAM3 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
    SP1:                    -                                   -                                       
    SP2:                    -                                                                           
    SP3:                    -                                                                           
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for ICAM3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ICAM3 expression in normal human tissues (normalized intensities)      ICAM3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAGGGAGGA
    ICAM3 Expression
    About this image


    ICAM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone marrow-derived adherent progenitor cells (MultiStem)
             BONE MARROW   
     
     Blood (Hematopoietic System)
             BONE MARROW   
     
     Adipose (Muscoskeletal System)
             Stromal Cells Subcutaneous White Adipose
     
     Inner Cell Mass (Early Embryonic Tissues)
             CyT49
     
     Lymph (Hematopoietic System)
             Lymphnode   

    See ICAM3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ICAM3

    SOURCE GeneReport for Unigene cluster: Hs.654563
        SABiosciences Custom PCR Arrays for ICAM3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ICAM3 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia ICAM31 intercellular adhesion molecule 3 76.2(n)
    66.67(a)
      100683931  XM_003432853.1  XP_003432901.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    26(a)
    24(a)
    many → 1
    possible ortholog
    GL344305.1(30522-49910)
    GL343233.1(1353200-1357090)


    ENSEMBL Gene Tree for ICAM3 (if available)
    TreeFam Gene Tree for ICAM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ICAM3 gene
    ICAM42  ICAM52  ICAM22  ICAM12  
    5 SIMAP similar genes for ICAM3 using alignment to 9 protein entries:     ICAM3_HUMAN (see all proteins):
    ICAM5    P3.58    ICAM1    ICAM-1    ICAM2

    ICAM3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/161 SNPs in ICAM3 are shown (see all 161)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0244984
    ----see VAR_0244982 S T mis40--------
    rs1486838881,2
    C--10446448(+) CGTGGA/TCGTCT 2 D V mis10--------
    rs1484315511,2
    C,F--10446494(+) CTCCTC/TCACTG 2 K E mis12Minor allele frequency- T:0.00NA EU 5135
    rs1998131691,2
    --10446526(+) CCTCCC/TAGCGA 2 * W stg10--------
    rs23042371,2,4
    C,F,A,H--10446568(+) ACCCAT/CCCTCC 2 /D /G mis1 ese328Minor allele frequency- C:0.18EA NA NS CSA WA EU 7709
    rs773585031,2
    C,F--10446672(+) GAGGAT/GGGCAC 1 -- int11Minor allele frequency- G:0.05EA 120
    rs2814131,2
    C,F,A,H--10446734(+) AGGGTG/AGTCCT 1 -- int127Minor allele frequency- A:0.17MN NA NS EA WA CSA 2960
    rs10581541,2
    C,F,H--10446897(+) TGGCAC/AAATAA 1 -- int112Minor allele frequency- A:0.15NA NS EA CSA 564
    rs1122374321,2
    C--10446900(+) AAAAA-/ATGAGG 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs31767691,2
    C,F--10447034(-) GACCTT/CTTGAT 1 -- int17Minor allele frequency- C:0.17NA CSA WA EA 404

    HapMap Linkage Disequilibrium report for ICAM3 (10444452 - 10450499 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ICAM3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv470125CNV Loss18288195
    nsv911029CNV Loss21882294
    dgv3725n71CNV Loss21882294
    nsv911040CNV Loss21882294
    nsv911030CNV Loss21882294
    dgv3726n71CNV Loss21882294
    nsv518008CNV Gain19592680
    nsv470124CNV Gain18288195

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 146631    OMIM disorders: --

    20/39 diseases for ICAM3 (see all 39):    About MalaCards
    colon carcinoma in situ    tick-borne encephalitis    vernal keratoconjunctivitis    severe acute respiratory syndrome
    membranoproliferative glomerulonephritis    keratoconjunctivitis    human t-cell leukemia virus type 1    encephalitis
    adult t-cell leukemia    hiv type 1    mycosis fungoides    skin disease
    t-cell leukemia    ulcerative colitis    eosinophilia    inflammatory bowel disease
    vasculitis    psoriasis    glomerulonephritis    crohn's disease


    ICAM3 for disorders           About GeneDecksing

    10/21 Novoseek inferred disease relationships for ICAM3 gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 36.7 8 11799181 (1), 12477827 (1), 14970226 (1), 16641270 (1) (see all 8)
    inflammation 34.6 3 17701178 (1), 8579109 (1), 16792588 (1)
    asthma allergic 23.1 1 11964048 (1)
    colitis ulcerative 20.1 3 9471026 (1), 9473377 (1), 10931137 (1)
    autoimmune response 16.1 1 7523142 (1)
    dermatitis atopic 9.59 5 8547030 (2)
    psoriasis 5.29 7 8547030 (2), 8721479 (1), 12854881 (1)
    cancer 1.74 8 19956847 (3), 8579109 (1)
    inflammatory bowel diseases 0.626 1 10931137 (1)
    hiv infections 0.307 1 17530994 (1)

    Genetic Association Database (GAD): ICAM3
    Human Genome Epidemiology (HuGE) Navigator: ICAM3 (13 documents)

    Export disorders for ICAM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ICAM3 gene, integrated from 9 sources (see all 235):
    (articles sorted by number of sources associating them with ICAM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a new intercellular adhesion molecule ICAM-R. (PubMed id 1448174)1, 2, 3, 9 Vazeux R.... Gallatin W.M. (1992)
    2. Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes. (PubMed id 1448173)1, 2, 9 Fawcett J.... Simmons D.L. (1992)
    3. Structural study of N-linked oligosaccharides of human intercellular adhesion molecule-3 (CD50). (PubMed id 11179968)1, 2, 9 Funatsu O....Furukawa K. (2001)
    4. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    5. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (2010)
    8. Functional role of ICAM-3 polymorphism in genetic sus ceptibility to SARS infection. (PubMed id 19801714)1, 4 Khoo U.S....Peiris J.S. (2009)
    9. Genetic variants at CD28, PRDM1 and CD2/CD58 are asso ciated with rheumatoid arthritis risk. (PubMed id 19898481)1, 4 Raychaudhuri S....Plenge R.M. (2009)
    10. Association of ICAM3 genetic variant with severe acute respiratory syndrome. (PubMed id 17570115)1, 4 Chan K.Y....Khoo U.S. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3385 HGNC: 5346 AceView: ICAM3andMGC19604andRAVER1 Ensembl:ENSG00000076662 euGenes: HUgn3385
    ECgene: ICAM3 Kegg: 3385 H-InvDB: ICAM3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ICAM3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ICAM3 Genetics and Cytogenetics in Oncology and Haematology
    R&D Systems' cytokine source book: ICAM-3http://www.rndsystems.com/molecule_detail.aspx?m=1589
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_263

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ICAM3 gene:
    Search GeneIP for patents involving ICAM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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