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Set Analyses:

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ICAM3 Gene

protein-coding GIFtS: 67
GCID: GC19M010444

Intercellular Adhesion Molecule 3

Microbiology & Infectious Diseases Congress

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at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Intercellular Adhesion Molecule 3¹ ²		CD50²
ICAM-3² ³		Intercellular Adhesion Molecule-3²
ICAM-R² ³		CDw50³
CDW50² ⁵		CD50 Antigen³

External Ids:	HGNC: 5346¹	Entrez Gene: 3385²	Ensembl: ENSG00000076662⁷	OMIM: 146631⁵	UniProtKB: P32942³

Export aliases for ICAM3 gene to outside databases

Previous GC identifers: GC19M010565 GC19M010667 GC19M010289 GC19M010305 GC19M010024

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ICAM3 Gene:

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM

proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the

leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and

may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an

adhesion molecule, but also as a potent signalling molecule. (provided by RefSeq, Jul 2008)

GeneCards Summary for ICAM3 Gene:

ICAM3 (intercellular adhesion molecule 3) is a protein-coding gene. Diseases associated with ICAM3 include colon carcinoma in situ, and tick-borne encephalitis. GO annotations related to this gene include integrin binding and receptor binding. An important paralog of this gene is ICAM4.

UniProtKB/Swiss-Prot: ICAM3_HUMAN, P32942

Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is

also a ligand for integrin alpha-D/beta-2

Gene Wiki entry for ICAM3 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000019.10 NC_018930.2 NT_011295.12

Regulatory elements:

Regulatory transcription factor binding sites in the ICAM3 gene promoter:
Pax-3 Sp1 Bach2 Tal-1beta
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ICAM3 promoter sequence

Search Chromatin IP Primers for ICAM3

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ICAM3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3-p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.3-p13.2

ICAM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ICAM3 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M010444: view genomic region (about GC identifiers)

Start:	10,444,452 bp from pter	End:	10,450,499 bp from pter
Size:	6,048 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ICAM3_HUMAN, P32942 (See protein sequence)

Recommended Name: Intercellular adhesion molecule 3 precursor

Size: 547 amino acids; 59541 Da

1 PDB 3D structure from and Proteopedia for ICAM3:

1T0P (3D)

Secondary accessions: Q6PD68

Explore the universe of human proteins at neXtProt for ICAM3: NX_P32942

Explore proteomics data for ICAM3 at MOPED

Post-translational modifications:

Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues¹

N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose

chains¹

Glycosylation² at Asn52, Asn84, Asn87, Asn91, Asn101, Asn110, Asn134, Asn206, Asn264, Asn295,
Asn308, Asn320, Asn363, Asn389, Asn453, Asn457

Modification sites at PhosphoSitePlus

See ICAM3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_002153.2

ENSEMBL proteins:

ENSP00000160262 ENSP00000468230 ENSP00000468333 ENSP00000467232 ENSP00000466501

ENSP00000467770 ENSP00000466081 ENSP00000468282

Reactome Protein details: P32942

ICAM3 Human Recombinant Protein Products:

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	Novus Biologicals ICAM3 Proteins Novus Biologicals ICAM3 Lysate
	Sino Biological Recombinant Protein for ICAM3 Sino Biological Cell Lysate for ICAM3
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ICAM3 Antibody Products:

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	Novus Biologicals ICAM3 Antibodies
	Abcam antibodies for ICAM3
	Cloud-Clone Corp. Antibodies for ICAM3
	ThermoFisher Antibody for ICAM3
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ICAM3 Assay Products:

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	GenScript Custom Assay Services for ICAM3
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	Cloud-Clone Corp. ELISAs for ICAM3 Cloud-Clone Corp. CLIAs for ICAM3

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

CD: CD molecules

IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

Selected InterPro protein domains (see all 6):

IPR003988 ICAM

IPR013768 ICAM_N

IPR013783 Ig-like_fold

IPR007110 Ig-like_dom

IPR003599 Ig_sub

Graphical View of Domain Structure for InterPro Entry P32942

ProtoNet protein and cluster: P32942

4 Blocks protein domains:

IPB003599 Immunoglobulin subtype

IPB003987 Intercellular adhesion molecule/vascular cell adhesion molecule-1 signature

IPB003988 Intercellular adhesion molecule (ICAM) family signature

IPB013768 Intercellular adhesion molecule

UniProtKB/Swiss-Prot: ICAM3_HUMAN, P32942

Similarity: Belongs to the immunoglobulin superfamily. ICAM family

Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains

ICAM3 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: ICAM3_HUMAN, P32942

Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is

also a ligand for integrin alpha-D/beta-2

Genatlas biochemistry entry for ICAM3:

adhesion molecule intercellular 3,ligand for LFA1,counterreceptor,expressed only on the leukocytes interacting

with moesin and promoting its redistribution to the uropod of T lymphocytes during cell polarization,Ig

superfamily

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	TAS	8459213
GO:0005178	integrin binding	IPI	1448173
GO:0005515	protein binding	IPI	12082081

ICAM3 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ICAM3

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ICAM3

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ICAM3

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ICAM3

miRNA Products:		miRTarBase miRNAs that target ICAM3: hsa-mir-192-5p (MIRT026424)

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		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for ICAM3
		Predesigned siRNA for gene silencing in human, mouse, rat ICAM3

Gene Editing
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		Sino Biological Human cDNA Clone for ICAM3
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		Browse ESI BIO Cell Lines and PureStem Progenitors for ICAM3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM3

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

ICAM3_HUMAN, P32942: Membrane; Single-pass type I membrane protein

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	4
cytoskeleton	2
endosome	1
extracellular	1
lysosome	1
nucleus	1
vacuole	1

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Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral component of plasma membrane	TAS	8459213
GO:0016020	membrane	--	--
GO:0070062	extracellular vesicular exosome	IDA	--

ICAM3 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ICAM3 About (see all 7)

See pathways by source

SuperPath

Contained pathways About

Class I MHC mediated antigen processing and presentation

Adaptive Immune System

0.41

Degradation of the extracellular matrix

Extracellular matrix organization

0.34

Integrin cell surface interactions

Integrin cell surface interactions

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Immune response Role of integrins in NK cells cytotoxicity

Immune response Role of integrins in NK cells cytotoxicity

Pathways by source See SuperPaths
Show all pathways

1 GeneGo (Thomson Reuters) Pathway for ICAM3

Immune response Role of integrins in NK cells cytotoxicity

1 BioSystems Pathway for ICAM3

IL-5 Signaling Pathway

2 Reactome Pathways for ICAM3

	Integrin cell surface interactions
	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

1 Kegg Pathway (Kegg details for ICAM3):

Cell adhesion molecules (CAMs)

ICAM3 for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for ICAM3
Interactions:

GeneGlobe Interaction Network for ICAM3

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

Selected Interacting proteins for ICAM3 (P32942^{2, 3} ENSP00000160262⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ZBTB16	Q05516²^,³, ENSP00000338157⁴	MINT-63670 I2D: score=4 STRING: ENSP00000338157
EZR	P15311³, ENSP00000338934⁴	I2D: score=3 STRING: ENSP00000338934
ITGB2	P05107³, ENSP00000303242⁴	I2D: score=2 STRING: ENSP00000303242
PRKCQ	Q04759³, ENSP00000263125⁴	I2D: score=2 STRING: ENSP00000263125
CD209	Q9NNX6³, ENSP00000315477⁴	I2D: score=1 STRING: ENSP00000315477

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Gene Ontology (GO): 3 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016337	cell-cell adhesion	IEA	--
GO:0030198	extracellular matrix organization	TAS	--
GO:0050776	regulation of immune response	TAS	--

ICAM3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for ICAM3

10 Novoseek inferred chemical compound relationships for ICAM3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
n-formylmethionyl-leucylphenylalanine	38.6	2	10733515 (1), 14723618 (1)
polysaccharide	16.9	2	15545280 (1), 17145745 (1)
mannose	16	1	15545280 (1)
fmlp	12.1	1	14723618 (1)
rantes	9.47	3	9298994 (2), 9174593 (1)
phosphatidylinositol	0.949	1	11784723 (1)
calcium	0	6	9672149 (3), 10688433 (2)
tyrosine	0	7	7520448 (5)
carbohydrates	0	1	12234361 (1)
dexamethasone	0	2	10688433 (1), 8730134 (1)

ICAM3 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ICAM3 gene:

NM_002162.3

Unigene Cluster for ICAM3:

Intercellular adhesion molecule 3

Hs.654563 [show with all ESTs]

Unigene Representative Sequence: BC046121

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000589900 ENST00000587992 ENST00000160262(uc002mob.2 uc010dxd.1 uc010xlf.1)

ENST00000592945 ENST00000589261 ENST00000592439 ENST00000585439 ENST00000590569

ENST00000589249 ENST00000589580

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		Block miRNA regulation of human, mouse, rat ICAM3 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate ICAM3
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for ICAM3
		Predesigned siRNA for gene silencing in human, mouse, rat ICAM3

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		GenScript: all cDNA clones in your preferred vector: ICAM3 (NM_002162)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICAM3

Primer Products:		OriGene qPCR primer pairs and template standards for ICAM3 OriGene qSTAR qPCR primer pairs in human, mouse for ICAM3
		Pre-validated RT² qPCR Primer Assay in human, mouse / rat ICAM3
		QuantiTect SYBR Green Assays in human, mouse, rat ICAM3
		QuantiFast Probe-based Assays in human, mouse, rat ICAM3

Additional mRNA sequence:

AF340060.1 AF340061.1 AK226023.1 AK301071.1 AK309643.1 AK312826.1 BC034409.1 BC040123.1

BC046121.1 BC058903.1 S50015.1 X69711.1 X69819.1

7 DOTS entries:

DT.453621 DT.40250724 DT.100786949 DT.99993152 DT.92049816 DT.92424245 DT.100786951

Selected AceView cDNA sequences (see all 529):

BU183371 BM450446 BM726266 BQ446829 BG257988 BM927456 BQ548716 BQ926069

BE257181 AI298330 N95446 BC037428 BC044225 CR594982 BQ101075 BM675275

BM926198 BC058903 AI080260 AB075858 CR590285 BQ066216 BM715373 CA395513

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for ICAM3 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6	^	7a	·	7b	·	7c
SP1:							-												-
SP2:							-
SP3:							-
SP4:
SP5:

ECgene alternative splicing isoforms for ICAM3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ICAM3 expression in normal human tissues (normalized intensities) ICAM3 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTAGGGAGGA

About this image

ICAM3 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 6) fully expand


Bone (Muscoskeletal System) fully expand to see all 4 entries
Bone Marrow
Bone marrow-derived adherent progenitor cells (MultiStem)

Inner Cell Mass (Early Embryonic Tissues) fully expand to see all 2 entries
Human embryonic stem cells (family)

Mesenchymal Stem Cells
Bone marrow-derived mesenchymal stem cells

Blood (Hematopoietic System)
Granulocytes Peripheral Blood

Adipose (Muscoskeletal System)
Stromal Cells Subcutaneous White Adipose

ICAM3 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ICAM3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.654563

Custom PCR Arrays for ICAM3

Primer Products:		OriGene qPCR primer pairs and template standards for ICAM3 OriGene qSTAR qPCR primer pairs in human, mouse for ICAM3
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		QuantiFast Probe-based Assays in human, mouse, rat ICAM3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ICAM3 gene from Selected species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- --	Uncharacterized protein	25(a) 24(a)	many ↔ many many ↔ many	GL344305.1(30522-49910) GL343233.1(1353200-1357090)

Species with no ortholog for ICAM3

ENSEMBL Gene Tree for ICAM3 (if available)
TreeFam Gene Tree for ICAM3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ICAM3 gene

ICAM4² ICAM5² ICAM2² ICAM1²

5 SIMAP similar genes for ICAM3 using alignment to 9 protein entries: ICAM3_HUMAN (see all proteins):

ICAM5 P3.58 ICAM1 ICAM-1 ICAM2

ICAM3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs148683888^1,2	C	--	10446448(+)	`CGTGGA/TCGTCT`	2	D V	mis¹		0	--	--	--	--
rs148431551^1,2	C,F	--	10446494(+)	`CTCCTC/TCACTG`	2	K E	mis¹		2		NA EU	5135
rs199813169^1,2		--	10446526(+)	`CCTCCC/TAGCGA`	2	* W	stg¹		0	--	--	--	--
rs2304237^1,2,,4	C,F,A,H	--	10446568(+)	`ACCCAT/CCCTCC`	2	/D /G	mis¹ ese³		28		EA NA NS CSA WA EU	7709
rs77358503^1,2	C,F	--	10446672(+)	`GAGGAT/GGGCAC`	1	--	int¹		1		EA	120
rs281413^1,2	C,F,A,H	--	10446734(+)	`AGGGTG/AGTCCT`	1	--	int¹		27		MN NA NS EA WA CSA	2960
rs1058154^1,2	C,F,H	--	10446897(+)	`TGGCAC/AAATAA`	1	--	int¹		12		NA NS EA CSA	564
rs112237432^1,2	C	--	10446900(+)	`AAAAA-/ATGAGG`	1	--	int¹		1		CSA	2
rs3176769^1,2	C,F	--	10447034(-)	`GACCTT/CTTGAT`	1	--	int¹		7		NA CSA WA EA	404
rs142229827^1,2	C	--	10447075(+)	`AGACAC/TTCAGG`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ICAM3 (10444452 - 10450499 bp)

Structural Variations
Database of Genomic Variants (DGV) 8 variations for ICAM3: About this table

Variant ID	Type	Subtype	PubMed ID
nsv470125	CNV	Loss	18288195
nsv911029	CNV	Loss	21882294
dgv3725n71	CNV	Loss	21882294
nsv911040	CNV	Loss	21882294
nsv911030	CNV	Loss	21882294
dgv3726n71	CNV	Loss	21882294
nsv518008	CNV	Gain	19592680
nsv470124	CNV	Gain	18288195

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ICAM3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 146631 OMIM disorders: --

Selected diseases for ICAM3 (see all 43): About MalaCards

colon carcinoma in situ tick-borne encephalitis vernal keratoconjunctivitis severe acute respiratory syndrome

membranoproliferative glomerulonephritis primary progressive multiple sclerosis keratoconjunctivitis human t-cell leukemia virus type 1

adult t-cell leukemia encephalitis skin disease mycosis fungoides

crohn's disease ulcerative colitis relapsing-remitting multiple sclerosis t-cell leukemia

inflammatory bowel disease psoriasis eosinophilia vasculitis

ICAM3 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

Selected Novoseek inferred disease relationships for ICAM3 gene (see all 21) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
immunodeficiency	36.7	8	11799181 (1), 12477827 (1), 14970226 (1), 16641270 (1) (see all 8)
inflammation	34.6	3	17701178 (1), 8579109 (1), 16792588 (1)
asthma allergic	23.1	1	11964048 (1)
colitis ulcerative	20.1	3	9471026 (1), 9473377 (1), 10931137 (1)
autoimmune response	16.1	1	7523142 (1)
dermatitis atopic	9.59	5	8547030 (2)
psoriasis	5.29	7	8547030 (2), 8721479 (1), 12854881 (1)
cancer	1.74	8	19956847 (3), 8579109 (1)
inflammatory bowel diseases	0.626	1	10931137 (1)
hiv infections	0.307	1	17530994 (1)

Genetic Association Database (GAD): ICAM3
Human Genome Epidemiology (HuGE) Navigator: ICAM3 (13 documents)

Export disorders for ICAM3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ICAM3 gene, integrated from 10 sources (see all 237):
(articles sorted by number of sources associating them with ICAM3)

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Cloning and characterization of a new intercellular adhesion molecule ICAM-R. (PubMed id 1448174)^{1, 2, 3, 9} Vazeux R.... Gallatin W.M. (Nature 1992)
Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes. (PubMed id 1448173)^{1, 2, 9} Fawcett J.... Simmons D.L. (Nature 1992)
Structural study of N-linked oligosaccharides of human intercellular adhesion molecule-3 (CD50). (PubMed id 11179968)^{1, 2, 9} Funatsu O....Furukawa K. (Eur. J. Biochem. 2001)
Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)^{1, 4} Rajaraman P....Inskip P.D. (amp 2010)
Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)^{1, 4} Han S....Kang D. (Hum. Immunol. 2010)
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)^{1, 4} Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
Functional role of ICAM-3 polymorphism in genetic susceptibility to SARS infection. (PubMed id 19801714)^{1, 4} Khoo U.S....Peiris J.S. (Hong Kong Med J 2009)
Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. (PubMed id 19898481)^{1, 4} Raychaudhuri S....Plenge R.M. (Nat. Genet. 2009)
Association of ICAM3 genetic variant with severe acute respiratory syndrome. (PubMed id 17570115)^{1, 4} Chan K.Y....Khoo U.S. (J. Infect. Dis. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3385	HGNC: 5346	AceView: ICAM3andMGC19604andRAVER1	Ensembl:ENSG00000076662	euGenes: HUgn3385
ECgene: ICAM3	Kegg: 3385	H-InvDB: ICAM3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ICAM3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ICAM3	Genetics and Cytogenetics in Oncology and Haematology
R&D Systems' cytokine source book: ICAM-3	http://www.rndsystems.com/molecule_detail.aspx?m=1589
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_263

Intellectual Property for ICAM3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ICAM3 gene:
Search GeneIP for patents involving ICAM3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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Intercellular Adhesion Molecule 3

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ICAM3 Gene

Intercellular Adhesion Molecule 3

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