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ICAM3 Gene

protein-coding   GIFtS: 67
GCID: GC19M010444

Intercellular Adhesion Molecule 3

  See ICAM3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Intercellular Adhesion Molecule 31 2     CD502
ICAM-32 3     Intercellular Adhesion Molecule-32
ICAM-R2 3     CDw503
CDW502 5     CD50 Antigen3

External Ids:    HGNC: 53461   Entrez Gene: 33852   Ensembl: ENSG000000766627   OMIM: 1466315   UniProtKB: P329423   

Export aliases for ICAM3 gene to outside databases

Previous GC identifers: GC19M010565 GC19M010667 GC19M010289 GC19M010305 GC19M010024


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ICAM3 Gene:
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM
proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the
leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and
may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an
adhesion molecule, but also as a potent signalling molecule. (provided by RefSeq, Jul 2008)

GeneCards Summary for ICAM3 Gene:
ICAM3 (intercellular adhesion molecule 3) is a protein-coding gene. Diseases associated with ICAM3 include multiple sclerosis. GO annotations related to this gene include integrin binding and receptor binding. An important paralog of this gene is ICAM4.

UniProtKB/Swiss-Prot: ICAM3_HUMAN, P32942
Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is
also a ligand for integrin alpha-D/beta-2

Gene Wiki entry for ICAM3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the ICAM3 gene promoter:
         Pax-3   Sp1   Bach2   Tal-1beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidICAM3 promoter sequence
   Search Chromatin IP Primers for ICAM3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ICAM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3-p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.3-p13.2

ICAM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ICAM3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M010444:  view genomic region     (about GC identifiers)

Start:
10,444,452 bp from pter      End:
10,450,499 bp from pter
Size:
6,048 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ICAM3_HUMAN, P32942 (See protein sequence)
Recommended Name: Intercellular adhesion molecule 3 precursor  
Size: 547 amino acids; 59541 Da
1 PDB 3D structure from and Proteopedia for ICAM3:
1T0P (3D)    
Secondary accessions: Q6PD68

Explore the universe of human proteins at neXtProt for ICAM3: NX_P32942

Explore proteomics data for ICAM3 at MOPED

Post-translational modifications: 

  • Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues1
  • N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose
    chains1
  • Glycosylation2 at Asn52, Asn84, Asn87, Asn91, Asn101, Asn110, Asn134, Asn206, Asn264, Asn295,
                                 Asn308, Asn320, Asn363, Asn389, Asn453, Asn457
  • Modification sites at PhosphoSitePlus

  • See ICAM3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002153.2  
    ENSEMBL proteins: 
     ENSP00000160262   ENSP00000468230   ENSP00000468333   ENSP00000467232   ENSP00000466501  
     ENSP00000467770   ENSP00000466081   ENSP00000468282  
    Reactome Protein details: P32942

    ICAM3 Human Recombinant Protein Products:

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    Novus Biologicals ICAM3 Proteins
    Novus Biologicals ICAM3 Lysate
    Sino Biological Recombinant Protein for ICAM3
    Sino Biological Cell Lysate for ICAM3
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    Cloud-Clone Corp. Proteins for ICAM3

     
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    ICAM3 Antibody Products:

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    ICAM3 Assay Products:

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    Cloud-Clone Corp. ELISAs for ICAM3
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    Search eBioscience for ELISAs for ICAM3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    Selected InterPro protein domains (see all 6):
     IPR003988 ICAM
     IPR013768 ICAM_N
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P32942

    ProtoNet protein and cluster: P32942

    4 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB003987 Intercellular adhesion molecule/vascular cell adhesion molecule-1 signature
    IPB003988 Intercellular adhesion molecule (ICAM) family signature
    IPB013768 Intercellular adhesion molecule


    UniProtKB/Swiss-Prot: ICAM3_HUMAN, P32942
    Similarity: Belongs to the immunoglobulin superfamily. ICAM family
    Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with ICAM3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ICAM3_HUMAN, P32942
    Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is
    also a ligand for integrin alpha-D/beta-2

         Genatlas biochemistry entry for ICAM3:
    adhesion molecule intercellular 3,ligand for LFA1,counterreceptor,expressed only on the leukocytes interacting
    with moesin and promoting its redistribution to the uropod of T lymphocytes during cell polarization,Ig
    superfamily

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS8459213
    GO:0005178integrin binding IPI1448173
    GO:0005515protein binding IPI12082081
         
    Find genes that share ontologies with ICAM3           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ICAM3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ICAM3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ICAM3

    miRNA
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    miRTarBase miRNAs that target ICAM3:
    hsa-mir-192-5p (MIRT026424)

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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ICAM3
    Predesigned siRNA for gene silencing in human, mouse, rat ICAM3

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: ICAM3 (NM_002162)
    Sino Biological Human cDNA Clone for ICAM3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ICAM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICAM3
    Addgene plasmids for ICAM3 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ICAM3_HUMAN, P32942: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton2
    endosome1
    extracellular1
    lysosome1
    nucleus1
    vacuole1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8459213
    GO:0016020membrane ----
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with ICAM3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ICAM3 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    2Degradation of the extracellular matrix
    Extracellular matrix organization0.34
    3Integrin cell surface interactions
    Integrin cell surface interactions
    4Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    5Immune response Role of integrins in NK cells cytotoxicity
    Immune response Role of integrins in NK cells cytotoxicity


    Find genes that share SuperPaths with ICAM3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ICAM3
        Immune response Role of integrins in NK cells cytotoxicity

    1 BioSystems Pathway for ICAM3
        IL-5 Signaling Pathway


    2 Reactome Pathways for ICAM3
        Integrin cell surface interactions
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    1 Kegg Pathway  (Kegg details for ICAM3):
        Cell adhesion molecules (CAMs)

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ICAM3
    Interactions:

        GeneGlobe Interaction Network for ICAM3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for ICAM3 (P329422, 3 ENSP000001602624) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZBTB16Q055162, 3, ENSP000003381574MINT-63670 I2D: score=4 STRING: ENSP00000338157
    EZRP153113, ENSP000003389344I2D: score=3 STRING: ENSP00000338934
    ITGB2P051073, ENSP000003032424I2D: score=2 STRING: ENSP00000303242
    PRKCQQ047593, ENSP000002631254I2D: score=2 STRING: ENSP00000263125
    CD209Q9NNX63, ENSP000003154774I2D: score=1 STRING: ENSP00000315477
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016337cell-cell adhesion IEA--
    GO:0030198extracellular matrix organization TAS--
    GO:0050776regulation of immune response TAS--

    Find genes that share ontologies with ICAM3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ICAM3

    10 Novoseek inferred chemical compound relationships for ICAM3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-formylmethionyl-leucylphenylalanine 38.6 2 10733515 (1), 14723618 (1)
    polysaccharide 16.9 2 15545280 (1), 17145745 (1)
    mannose 16 1 15545280 (1)
    fmlp 12.1 1 14723618 (1)
    rantes 9.47 3 9298994 (2), 9174593 (1)
    phosphatidylinositol 0.949 1 11784723 (1)
    calcium 0 6 9672149 (3), 10688433 (2)
    tyrosine 0 7 7520448 (5)
    carbohydrates 0 1 12234361 (1)
    dexamethasone 0 2 10688433 (1), 8730134 (1)



    Find genes that share compounds with ICAM3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ICAM3 gene: 
    NM_002162.3  

    Unigene Cluster for ICAM3:

    Intercellular adhesion molecule 3
    Hs.654563  [show with all ESTs]
    Unigene Representative Sequence: BC046121
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589900 ENST00000587992 ENST00000160262(uc002mob.2 uc010dxd.1 uc010xlf.1)
    ENST00000592945 ENST00000589261 ENST00000592439 ENST00000585439 ENST00000590569
    ENST00000589249 ENST00000589580
    miRNA
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    Addgene plasmids for ICAM3 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ICAM3
      QuantiTect SYBR Green Assays in human, mouse, rat ICAM3
      QuantiFast Probe-based Assays in human, mouse, rat ICAM3

    Additional mRNA sequence: 

    AF340060.1 AF340061.1 AK226023.1 AK301071.1 AK309643.1 AK312826.1 BC034409.1 BC040123.1 
    BC046121.1 BC058903.1 S50015.1 X69711.1 X69819.1 

    7 DOTS entries:

    DT.453621  DT.40250724  DT.100786949  DT.99993152  DT.92049816  DT.92424245  DT.100786951 

    Selected AceView cDNA sequences (see all 529):

    BU183371 BM450446 BM726266 BQ446829 BG257988 BM927456 BQ548716 BQ926069 
    BE257181 AI298330 N95446 BC037428 BC044225 CR594982 BQ101075 BM675275 
    BM926198 BC058903 AI080260 AB075858 CR590285 BQ066216 BM715373 CA395513 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ICAM3 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
    SP1:                    -                                   -                                       
    SP2:                    -                                                                           
    SP3:                    -                                                                           
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for ICAM3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ICAM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAGGGAGGA
    ICAM3 Expression
    About this image


    ICAM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Bone Marrow
             Bone marrow-derived adherent progenitor cells (MultiStem)
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Adipose (Muscoskeletal System)
             Stromal Cells Subcutaneous White Adipose
    ICAM3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ICAM3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654563
        Custom PCR Arrays for ICAM3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ICAM3
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    QuantiFast Probe-based Assays in human, mouse, rat ICAM3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ICAM3 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    25(a)
    24(a)
    many ↔ many
    many ↔ many
    GL344305.1(30522-49910)
    GL343233.1(1353200-1357090)
            Species with no ortholog for ICAM3

    ENSEMBL Gene Tree for ICAM3 (if available)
    TreeFam Gene Tree for ICAM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ICAM3 gene
    ICAM42  ICAM52  ICAM22  ICAM12  
    5 SIMAP similar genes for ICAM3 using alignment to 9 protein entries:     ICAM3_HUMAN (see all proteins):
    ICAM5    P3.58    ICAM1    ICAM-1    ICAM2

    Find genes that share paralogs with ICAM3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ICAM3 (see all 161)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1486838881,2
    C--10446448(+) CGTGGA/TCGTCT 2 D V mis10--------
    rs1484315511,2
    C,F--10446494(+) CTCCTC/TCACTG 2 K E mis12Minor allele frequency- T:0.00NA EU 5135
    rs1998131691,2
    --10446526(+) CCTCCC/TAGCGA 2 * W stg10--------
    rs23042371,2,,4
    C,F,A,H--10446568(+) ACCCAT/CCCTCC 2 /D /G mis1 ese328Minor allele frequency- C:0.18EA NA NS CSA WA EU 7709
    rs773585031,2
    C,F--10446672(+) GAGGAT/GGGCAC 1 -- int11Minor allele frequency- G:0.05EA 120
    rs2814131,2
    C,F,A,H--10446734(+) AGGGTG/AGTCCT 1 -- int127Minor allele frequency- A:0.17MN NA NS EA WA CSA 2960
    rs10581541,2
    C,F,H--10446897(+) TGGCAC/AAATAA 1 -- int112Minor allele frequency- A:0.15NA NS EA CSA 564
    rs1122374321,2
    C--10446900(+) AAAAA-/ATGAGG 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs31767691,2
    C,F--10447034(-) GACCTT/CTTGAT 1 -- int17Minor allele frequency- C:0.17NA CSA WA EA 404
    rs1422298271,2
    C--10447075(+) AGACAC/TTCAGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for ICAM3 (10444452 - 10450499 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ICAM3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv470125CNV Loss18288195
    nsv911029CNV Loss21882294
    dgv3725n71CNV Loss21882294
    nsv911040CNV Loss21882294
    nsv911030CNV Loss21882294
    dgv3726n71CNV Loss21882294
    nsv518008CNV Gain19592680
    nsv470124CNV Gain18288195

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 146631    OMIM disorders: --

    1 disease for ICAM3:    
    About MalaCards
    multiple sclerosis


    Find genes that share disorders with ICAM3           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ICAM3 gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 36.7 8 11799181 (1), 12477827 (1), 14970226 (1), 16641270 (1) (see all 8)
    inflammation 34.6 3 17701178 (1), 8579109 (1), 16792588 (1)
    asthma allergic 23.1 1 11964048 (1)
    colitis ulcerative 20.1 3 9471026 (1), 9473377 (1), 10931137 (1)
    autoimmune response 16.1 1 7523142 (1)
    dermatitis atopic 9.59 5 8547030 (2)
    psoriasis 5.29 7 8547030 (2), 8721479 (1), 12854881 (1)
    cancer 1.74 8 19956847 (3), 8579109 (1)
    inflammatory bowel diseases 0.626 1 10931137 (1)
    hiv infections 0.307 1 17530994 (1)

    Genetic Association Database (GAD): ICAM3
    Human Genome Epidemiology (HuGE) Navigator: ICAM3 (13 documents)

    Export disorders for ICAM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ICAM3 gene, integrated from 10 sources (see all 237):
    (articles sorted by number of sources associating them with ICAM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a new intercellular adhesion molecule ICAM-R. (PubMed id 1448174)1, 2, 3, 9 Vazeux R.... Gallatin W.M. (Nature 1992)
    2. Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes. (PubMed id 1448173)1, 2, 9 Fawcett J.... Simmons D.L. (Nature 1992)
    3. Structural study of N-linked oligosaccharides of human intercellular adhesion molecule-3 (CD50). (PubMed id 11179968)1, 2, 9 Funatsu O....Furukawa K. (Eur. J. Biochem. 2001)
    4. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    8. Functional role of ICAM-3 polymorphism in genetic susceptibility to SARS infection. (PubMed id 19801714)1, 4 Khoo U.S....Peiris J.S. (Hong Kong Med J 2009)
    9. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. (PubMed id 19898481)1, 4 Raychaudhuri S....Plenge R.M. (Nat. Genet. 2009)
    10. Association of ICAM3 genetic variant with severe acute respiratory syndrome. (PubMed id 17570115)1, 4 Chan K.Y....Khoo U.S. (J. Infect. Dis. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3385 HGNC: 5346 AceView: ICAM3andMGC19604andRAVER1 Ensembl:ENSG00000076662 euGenes: HUgn3385
    ECgene: ICAM3 Kegg: 3385 H-InvDB: ICAM3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ICAM3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ICAM3 Genetics and Cytogenetics in Oncology and Haematology
    R&D Systems' cytokine source book: ICAM-3http://www.rndsystems.com/molecule_detail.aspx?m=1589
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_263

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ICAM3 gene:
    Search GeneIP for patents involving ICAM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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