ICAM3 Gene

Aliases
for ICAM3 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC19M010565 GC19M010667 GC19M010289 GC19M010305 GC19M010024

Summaries
for ICAM3 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for ICAM3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000019.9  NC_018930.2  NT_011295.12  

SwitchGear Promoter luciferase reporter plasmid: ICAM3 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ICAM3

ICAM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M010444:  view genomic region     (about GC identifiers)

Proteins
for ICAM3 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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1 PDB 3D structure from and Proteopedia for ICAM3:

1T0P (3D)    

Explore the universe of human proteins at neXtProt for ICAM3: NX_P32942

Explore proteomics data for ICAM3 at MOPED

Post-translational modifications: 

ICAM3 Human Recombinant Protein Products:

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	antibodies-online peptides for ICAM3

ICAM3 Antibody Products:

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ICAM3 Assay Products:

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Domains /
Families
for ICAM3 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P32942

Find genes that share domains with ICAM3           About GenesLikeMe

Function
for ICAM3 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for ICAM3

miRNA Products:		miRTarBase miRNAs that target ICAM3: hsa-mir-192-5p (MIRT026424)
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Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for ICAM3

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		Sino Biological Human cDNA Clone for ICAM3
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		Addgene plasmids for ICAM3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ICAM3
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM3

Localization
for ICAM3 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	4
cytoskeleton	2
endosome	1
extracellular	1
lysosome	1
nucleus	1
vacuole	1

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Gene Ontology (GO): 4 cellular component terms:    About this table

Pathways & Interactions
for ICAM3 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for ICAM3 About   (see all 7)   See pathways by source

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	SuperPath	Contained pathways About
1	Class I MHC mediated antigen processing and presentation	Adaptive Immune System 0.41
2	Degradation of the extracellular matrix	Extracellular matrix organization 0.34
3	Integrin cell surface interactions	Integrin cell surface interactions
4	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
5	Immune response_Role of integrins in NK cells cytotoxicity	Immune response_Role of integrins in NK cells cytotoxicity

1 GeneGo (Thomson Reuters) Pathway for ICAM3

Immune response Role of integrins in NK cells cytotoxicity

1 BioSystems Pathway for ICAM3

IL-5 Signaling Pathway

2 Reactome Pathways for ICAM3

	Integrin cell surface interactions
	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

1 Kegg Pathway  (Kegg details for ICAM3)

Cell adhesion molecules (CAMs)

Gene Ontology (GO): 3 biological process terms:    About this table

Drugs & Compounds
for ICAM3 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for ICAM3 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for ICAM3 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ICAM3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTAGGGAGGA

About this image

Bone (Muscoskeletal System)    fully expand to see all 4 entries
Bone Marrow
Bone marrow-derived adherent progenitor cells (MultiStem)
Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
Human embryonic stem cells (family)
Mesenchymal Stem Cells
Bone marrow-derived mesenchymal stem cells
Blood (Hematopoietic System)
Granulocytes Peripheral Blood
Adipose (Muscoskeletal System)
Stromal Cells Subcutaneous White Adipose

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM3

Orthologs
for ICAM3 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for ICAM3 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for ICAM3 gene

ICAM4²  ICAM5²  ICAM2²  ICAM1²  

5 SIMAP similar genes for ICAM3 using alignment to 9 protein entries:     ICAM3_HUMAN (see all proteins):

ICAM5    P3.58    ICAM1    ICAM-1    ICAM2

Find genes that share paralogs with ICAM3           About GenesLikeMe

Genomic Variants
for ICAM3 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ICAM3 (see all 161)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1486838881,2	C	--	10446448(+)	CGTGGA/TCGTCT	2	D V	mis1		0	--	--	--	--
rs1484315511,2	C,F	--	10446494(+)	CTCCTC/TCACTG	2	K E	mis1		2		NA EU	5135
rs1998131691,2		--	10446526(+)	CCTCCC/TAGCGA	2	* W	stg1		0	--	--	--	--
rs23042371,2,,4	C,F,A,H	--	10446568(+)	ACCCAT/CCCTCC	2	/D /G	mis1 ese3		28		EA NA NS CSA WA EU	7709
rs773585031,2	C,F	--	10446672(+)	GAGGAT/GGGCAC	1	--	int1		1		EA	120
rs2814131,2	C,F,A,H	--	10446734(+)	AGGGTG/AGTCCT	1	--	int1		27		MN NA NS EA WA CSA	2960
rs10581541,2	C,F,H	--	10446897(+)	TGGCAC/AAATAA	1	--	int1		12		NA NS EA CSA	564
rs1122374321,2	C	--	10446900(+)	AAAAA-/ATGAGG	1	--	int1		1		CSA	2
rs31767691,2	C,F	--	10447034(-)	GACCTT/CTTGAT	1	--	int1		7		NA CSA WA EA	404
rs1422298271,2	C	--	10447075(+)	AGACAC/TTCAGG	1	--	int1		0	--	--	--	--

HapMap Linkage Disequilibrium report for ICAM3 (10444452 - 10450499 bp)

Structural Variations
     Database of Genomic Variants (DGV) 8 variations for ICAM3:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv470125	CNV	Loss	18288195
nsv911029	CNV	Loss	21882294
dgv3725n71	CNV	Loss	21882294
nsv911040	CNV	Loss	21882294
nsv911030	CNV	Loss	21882294
dgv3726n71	CNV	Loss	21882294
nsv518008	CNV	Gain	19592680
nsv470124	CNV	Gain	18288195

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ICAM3

DNA2.0 Custom Variant and Variant Library Synthesis for ICAM3

Disorders / Diseases
for ICAM3 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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1 disease for ICAM3

Selected Novoseek inferred disease relationships for ICAM3 gene (see all 21)    About this table

Publications
for ICAM3 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

1. Cloning and characterization of a new intercellular adhesion molecule ICAM-R. (PubMed id 1448174)^{1, 2, 3, 9} Vazeux R.... Gallatin W.M. (Nature 1992)
2. Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes. (PubMed id 1448173)^{1, 2, 9} Fawcett J.... Simmons D.L. (Nature 1992)
3. Structural study of N-linked oligosaccharides of human intercellular adhesion molecule-3 (CD50). (PubMed id 11179968)^{1, 2, 9} Funatsu O....Furukawa K. (Eur. J. Biochem. 2001)
4. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)^{1, 4} Rajaraman P....Inskip P.D. (amp 2010)
5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)^{1, 4} Han S....Kang D. (Hum. Immunol. 2010)
6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
7. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)^{1, 4} Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
8. Functional role of ICAM-3 polymorphism in genetic susceptibility to SARS infection. (PubMed id 19801714)^{1, 4} Khoo U.S....Peiris J.S. (Hong Kong Med J 2009)
9. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. (PubMed id 19898481)^{1, 4} Raychaudhuri S....Plenge R.M. (Nat. Genet. 2009)
10. Association of ICAM3 genetic variant with severe acute respiratory syndrome. (PubMed id 17570115)^{1, 4} Chan K.Y....Khoo U.S. (J. Infect. Dis. 2007)

External Searches for ICAM3 gene

Genome Databases showing ICAM3 gene

Other Databases showing ICAM3 gene

Specialized Databases showing ICAM3 gene

Products
for ICAM3 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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