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Aliases for ICAM3 Gene

Aliases for ICAM3 Gene

  • Intercellular Adhesion Molecule 3 2 3
  • CDW50 3 4 6
  • ICAM-3 3 4
  • ICAM-R 3 4
  • Intercellular Adhesion Molecule-3 3
  • CD50 Antigen 4
  • CD50 3

External Ids for ICAM3 Gene

Summaries for ICAM3 Gene

Entrez Gene Summary for ICAM3 Gene

  • The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. [provided by RefSeq, Jul 2008]

GeneCards Summary for ICAM3 Gene

ICAM3 (Intercellular Adhesion Molecule 3) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Degradation of the extracellular matrix. GO annotations related to this gene include receptor binding and integrin binding. An important paralog of this gene is ICAM1.

UniProtKB/Swiss-Prot for ICAM3 Gene

  • ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2

Gene Wiki entry for ICAM3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICAM3 Gene

Genomics for ICAM3 Gene

Genomic Location for ICAM3 Gene

10,333,776 bp from pter
10,339,823 bp from pter
6,048 bases
Minus strand

Genomic View for ICAM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ICAM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICAM3 Gene

Regulatory Elements for ICAM3 Gene

Proteins for ICAM3 Gene

  • Protein details for ICAM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Intercellular adhesion molecule 3
    Protein Accession:
    Secondary Accessions:
    • Q6PD68

    Protein attributes for ICAM3 Gene

    547 amino acids
    Molecular mass:
    59541 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ICAM3 Gene

neXtProt entry for ICAM3 Gene

Proteomics data for ICAM3 Gene at MOPED

Post-translational modifications for ICAM3 Gene

  • N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains.
  • Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn52, Asn84, Asn87, Asn91, Asn101, Asn110, Asn134, Asn206, Asn264, Asn295, Asn308, Asn320, Asn363, Asn389, Asn453, and Asn457

Other Protein References for ICAM3 Gene

No data available for DME Specific Peptides for ICAM3 Gene

Domains for ICAM3 Gene

Gene Families for ICAM3 Gene

  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Suggested Antigen Peptide Sequences for ICAM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 5 Ig-like C2-type (immunoglobulin-like) domains.:
    • P32942
  • Belongs to the immunoglobulin superfamily. ICAM family.:
    • P32942
genes like me logo Genes that share domains with ICAM3: view

Function for ICAM3 Gene

Molecular function for ICAM3 Gene

GENATLAS Biochemistry: adhesion molecule intercellular 3,ligand for LFA1,counterreceptor,expressed only on the leukocytes interacting with moesin and promoting its redistribution to the uropod of T lymphocytes during cell polarization,Ig superfamily
UniProtKB/Swiss-Prot Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2

Gene Ontology (GO) - Molecular Function for ICAM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 8459213
GO:0005178 integrin binding IPI 1448173
GO:0005515 protein binding IPI 12082081
genes like me logo Genes that share ontologies with ICAM3: view

miRNA for ICAM3 Gene

miRTarBase miRNAs that target ICAM3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ICAM3 Gene

Localization for ICAM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICAM3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for ICAM3 Gene COMPARTMENTS Subcellular localization image for ICAM3 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 2
endosome 1
extracellular 1
lysosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ICAM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8459213
GO:0016020 membrane --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with ICAM3: view

Pathways for ICAM3 Gene

genes like me logo Genes that share pathways with ICAM3: view

Pathways by source for ICAM3 Gene

Gene Ontology (GO) - Biological Process for ICAM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0007155 cell adhesion IBA --
GO:0016337 single organismal cell-cell adhesion IEA --
GO:0030198 extracellular matrix organization TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with ICAM3: view

Compounds for ICAM3 Gene

(10) Novoseek inferred chemical compound relationships for ICAM3 Gene

Compound -log(P) Hits PubMed IDs
n-formylmethionyl-leucylphenylalanine 38.6 2
polysaccharide 16.9 2
mannose 16 1
fmlp 12.1 1
rantes 9.47 3
genes like me logo Genes that share compounds with ICAM3: view

Transcripts for ICAM3 Gene

Unigene Clusters for ICAM3 Gene

Intercellular adhesion molecule 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ICAM3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: -
SP3: -

Relevant External Links for ICAM3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ICAM3 Gene

mRNA expression in normal human tissues for ICAM3 Gene

mRNA differential expression in normal tissues according to GTEx for ICAM3 Gene

This gene is overexpressed in Whole Blood (35.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ICAM3 Gene

SOURCE GeneReport for Unigene cluster for ICAM3 Gene Hs.654563

genes like me logo Genes that share expressions with ICAM3: view

No data available for mRNA Expression by UniProt/SwissProt for ICAM3 Gene

Orthologs for ICAM3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ICAM3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ICAM3 35
  • 99.45 (n)
  • 98.54 (a)
ICAM3 36
  • 99 (a)
(Bos Taurus)
Mammalia ICAM3 35
  • 71.6 (n)
  • 59.74 (a)
ICAM3 36
  • 59 (a)
(Canis familiaris)
Mammalia -- 36
  • 32 (a)
ICAM3 35
  • 76.2 (n)
  • 66.67 (a)
(Mus musculus)
Mammalia Tcam1 36
  • 31 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 32 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 37 (a)
-- 36
  • 39 (a)
-- 36
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 24 (a)
-- 36
  • 25 (a)
Species with no ortholog for ICAM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ICAM3 Gene

Gene Tree for ICAM3 (if available)
Gene Tree for ICAM3 (if available)

Paralogs for ICAM3 Gene

Paralogs for ICAM3 Gene

Selected SIMAP similar genes for ICAM3 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with ICAM3: view

Variants for ICAM3 Gene

Sequence variations from dbSNP and Humsavar for ICAM3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs281413 -- 10,336,058(+) AGGGT(A/G)GTCCT intron-variant
rs281414 -- 10,339,609(+) ATGGT(A/G)GCCAT reference, synonymous-codon
rs281415 -- 10,340,317(+) GCTGA(G/T)TCCCT upstream-variant-2KB
rs1058154 -- 10,336,221(+) TGGCA(A/C)AATAA intron-variant
rs2304237 - 10,335,892(+) ACCCA(C/T)CCTCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ICAM3 Gene

Variant ID Type Subtype PubMed ID
nsv911029 CNV Loss 21882294
nsv911030 CNV Loss 21882294
dgv3725n71 CNV Loss 21882294
dgv3726n71 CNV Loss 21882294
nsv470124 CNV Gain 18288195
nsv911040 CNV Loss 21882294
nsv470125 CNV Loss 18288195
nsv518008 CNV Gain 19592680

Relevant External Links for ICAM3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICAM3 Gene

Disorders for ICAM3 Gene

(21) Novoseek inferred disease relationships for ICAM3 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 36.7 8
inflammation 34.6 3
asthma allergic 23.1 1
colitis ulcerative 20.1 3
autoimmune response 16.1 1

Relevant External Links for ICAM3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ICAM3: view

No data available for UniProtKB/Swiss-Prot for ICAM3 Gene

Publications for ICAM3 Gene

  1. Cloning and characterization of a new intercellular adhesion molecule ICAM-R. (PMID: 1448174) Vazeux R. … Gallatin W.M. (Nature 1992) 2 3 4 23
  2. Structural study of N-linked oligosaccharides of human intercellular adhesion molecule-3 (CD50). (PMID: 11179968) Funatsu O. … Furukawa K. (Eur. J. Biochem. 2001) 3 4 23
  3. Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes. (PMID: 1448173) Fawcett J. … Simmons D.L. (Nature 1992) 3 4 23
  4. Functional role of ICAM-3 polymorphism in genetic susceptibility to SARS infection. (PMID: 19801714) Khoo U.S. … Peiris J.S. (Hong Kong Med J 2009) 3 48
  5. Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. (PMID: 19898481) Raychaudhuri S. … Plenge R.M. (Nat. Genet. 2009) 3 48

Products for ICAM3 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ICAM3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ICAM3
    • Block miRNA regulation of ICAM3 using miScript Target Protectors
    • Addgene plasmids for ICAM3

    Sources for ICAM3 Gene

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