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Aliases for ICAM3 Gene

Aliases for ICAM3 Gene

  • Intercellular Adhesion Molecule 3 2 3 5
  • ICAM-3 3 4
  • ICAM-R 3 4
  • CDW50 3 4
  • Intercellular Adhesion Molecule-3 3
  • CD50 Antigen 4
  • CD50 3

External Ids for ICAM3 Gene

Previous GeneCards Identifiers for ICAM3 Gene

  • GC19M010565
  • GC19M010667
  • GC19M010289
  • GC19M010305
  • GC19M010444
  • GC19M010024

Summaries for ICAM3 Gene

Entrez Gene Summary for ICAM3 Gene

  • The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

GeneCards Summary for ICAM3 Gene

ICAM3 (Intercellular Adhesion Molecule 3) is a Protein Coding gene. Diseases associated with ICAM3 include relapsing-remitting multiple sclerosis and trichosporonosis. Among its related pathways are Cell adhesion molecules (CAMs) and Immune System. GO annotations related to this gene include receptor binding and integrin binding. An important paralog of this gene is ICAM1.

UniProtKB/Swiss-Prot for ICAM3 Gene

  • ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2.

Gene Wiki entry for ICAM3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICAM3 Gene

Genomics for ICAM3 Gene

Regulatory Elements for ICAM3 Gene

Enhancers for ICAM3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ICAM3 on UCSC Golden Path with GeneCards custom track

Promoters for ICAM3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ICAM3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ICAM3 Gene

Chromosome:
19
Start:
10,333,776 bp from pter
End:
10,339,829 bp from pter
Size:
6,054 bases
Orientation:
Minus strand

Genomic View for ICAM3 Gene

Genes around ICAM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICAM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICAM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICAM3 Gene

Proteins for ICAM3 Gene

  • Protein details for ICAM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32942-ICAM3_HUMAN
    Recommended name:
    Intercellular adhesion molecule 3
    Protein Accession:
    P32942
    Secondary Accessions:
    • Q6PD68

    Protein attributes for ICAM3 Gene

    Size:
    547 amino acids
    Molecular mass:
    59541 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ICAM3 Gene

neXtProt entry for ICAM3 Gene

Proteomics data for ICAM3 Gene at MOPED

Post-translational modifications for ICAM3 Gene

  • N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains.
  • Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues.
  • Glycosylation at Asn 52, Asn 84, Asn 87, Asn 91, Asn 101, Asn 110, Asn 134, Asn 206, Asn 264, Asn 295, Asn 308, Asn 320, Asn 363, Asn 389, Asn 453, and Asn 457
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ICAM3 Gene

Domains & Families for ICAM3 Gene

Suggested Antigen Peptide Sequences for ICAM3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P32942

UniProtKB/Swiss-Prot:

ICAM3_HUMAN :
  • Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. ICAM family.
Domain:
  • Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. ICAM family.
genes like me logo Genes that share domains with ICAM3: view

Function for ICAM3 Gene

Molecular function for ICAM3 Gene

GENATLAS Biochemistry:
adhesion molecule intercellular 3,ligand for LFA1,counterreceptor,expressed only on the leukocytes interacting with moesin and promoting its redistribution to the uropod of T lymphocytes during cell polarization,Ig superfamily
UniProtKB/Swiss-Prot Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2.
genes like me logo Genes that share phenotypes with ICAM3: view

Animal Model Products

CRISPR Products

miRNA for ICAM3 Gene

miRTarBase miRNAs that target ICAM3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ICAM3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ICAM3 Gene

Localization for ICAM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICAM3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ICAM3 Gene COMPARTMENTS Subcellular localization image for ICAM3 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 1
endosome 1
lysosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ICAM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ICAM3: view

Pathways & Interactions for ICAM3 Gene

genes like me logo Genes that share pathways with ICAM3: view

Pathways by source for ICAM3 Gene

1 KEGG pathway for ICAM3 Gene
1 GeneGo (Thomson Reuters) pathway for ICAM3 Gene

Gene Ontology (GO) - Biological Process for ICAM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016337 single organismal cell-cell adhesion IEA --
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with ICAM3: view

No data available for SIGNOR curated interactions for ICAM3 Gene

Drugs & Compounds for ICAM3 Gene

(3) Drugs for ICAM3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(7) Additional Compounds for ICAM3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ICAM3: view

Transcripts for ICAM3 Gene

Unigene Clusters for ICAM3 Gene

Intercellular adhesion molecule 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ICAM3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ICAM3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: -
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for ICAM3 Gene

GeneLoc Exon Structure for
ICAM3
ECgene alternative splicing isoforms for
ICAM3

Expression for ICAM3 Gene

mRNA expression in normal human tissues for ICAM3 Gene

mRNA differential expression in normal tissues according to GTEx for ICAM3 Gene

This gene is overexpressed in Whole Blood (x35.3).

Protein differential expression in normal tissues from HIPED for ICAM3 Gene

This gene is overexpressed in Nasal epithelium (18.4) and Neutrophil (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ICAM3 Gene



SOURCE GeneReport for Unigene cluster for ICAM3 Gene Hs.654563

genes like me logo Genes that share expression patterns with ICAM3: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ICAM3 Gene

Orthologs for ICAM3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ICAM3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ICAM3 35
  • 71.6 (n)
  • 59.74 (a)
ICAM3 36
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ICAM3 35
  • 76.2 (n)
  • 66.67 (a)
-- 36
  • 32 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia ICAM3 35
  • 99.45 (n)
  • 98.54 (a)
ICAM3 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 32 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tcam1 36
  • 31 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 37 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 24 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
Species with no ortholog for ICAM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ICAM3 Gene

ENSEMBL:
Gene Tree for ICAM3 (if available)
TreeFam:
Gene Tree for ICAM3 (if available)

Paralogs for ICAM3 Gene

Paralogs for ICAM3 Gene

genes like me logo Genes that share paralogs with ICAM3: view

Variants for ICAM3 Gene

Sequence variations from dbSNP and Humsavar for ICAM3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_024498 -
rs17697947 - 10,338,838(+) GGCGA(C/T)TTTCT reference, missense, utr-variant-5-prime
rs2304237 - 10,335,892(+) ACCCA(C/T)CCTCC reference, missense
rs7258015 - 10,338,682(+) CTCAC(C/T)GTACA reference, missense
rs7257871 -- 10,338,576(+) AGAAC(C/T)GTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ICAM3 Gene

Variant ID Type Subtype PubMed ID
nsv911029 CNV Loss 21882294
nsv911030 CNV Loss 21882294
dgv3725n71 CNV Loss 21882294
dgv3726n71 CNV Loss 21882294
nsv470124 CNV Gain 18288195
nsv911040 CNV Loss 21882294
nsv470125 CNV Loss 18288195
nsv518008 CNV Gain 19592680

Variation tolerance for ICAM3 Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.58; 78.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ICAM3 Gene

HapMap Linkage Disequilibrium report
ICAM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICAM3 Gene

Disorders for ICAM3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ICAM3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
relapsing-remitting multiple sclerosis
  • relapsing-remitting ms
trichosporonosis
colon carcinoma in situ
  • carcinoma in situ of colon
- elite association - COSMIC cancer census association via MalaCards
Search ICAM3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ICAM3

Genetic Association Database (GAD)
ICAM3
Human Genome Epidemiology (HuGE) Navigator
ICAM3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ICAM3
genes like me logo Genes that share disorders with ICAM3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ICAM3 Gene

Publications for ICAM3 Gene

  1. Cloning and characterization of a new intercellular adhesion molecule ICAM-R. (PMID: 1448174) Vazeux R. … Gallatin W.M. (Nature 1992) 2 3 4 23 67
  2. ICAM-3 enhances the migratory and invasive potential of human non-small cell lung cancer cells by inducing MMP-2 and MMP-9 via Akt and CREB. (PMID: 19956847) Park J.K. … Um H.D. (Int. J. Oncol. 2010) 3 23
  3. No significant effect of orally administered chemokine receptor 1 antagonist on intercellular adhesion molecule-3 expression in relapsing--remitting multiple sclerosis patients. (PMID: 20086017) Reuss R. … Oschmann P. (Mult. Scler. 2010) 3 23
  4. Intercellular adhesion molecule-3 binding of integrin alphaL beta2 requires both extension and opening of the integrin headpiece. (PMID: 18354203) Tang X.Y. … Tan S.M. (J. Immunol. 2008) 3 23
  5. DC-SIGN binds ICAM-3 isolated from peripheral human leukocytes through Lewis x residues. (PMID: 17145745) Bogoevska V. … Wagener C. (Glycobiology 2007) 3 23

Products for ICAM3 Gene

Sources for ICAM3 Gene

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