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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ICAM3 Gene

protein-coding   GIFtS: 65
GCID: GC19M010444

intercellular adhesion molecule 3
 Explore 43 diseases affiliated with
ICAM3 via
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 Human Malady Compendium 
Biological research products
for ICAM3    

Aliases
for ICAM3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Intercellular Adhesion Molecule 31 2     ICAM-32 3
ICAM-R1 2 3     Intercellular Adhesion Molecule-32
CDW501 2 5     CDw503
CD501 2     CD50 Antigen3

External Ids:    HGNC: 53461   Entrez Gene: 33852   Ensembl: ENSG000000766627   OMIM: 1466315   UniProtKB: P329423   

Export aliases for ICAM3 gene to outside databases

Previous GC identifers: GC19M010565 GC19M010667 GC19M010289 GC19M010305 GC19M010024


Summaries
for ICAM3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ICAM3:
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins
are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte
adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most
important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule,
but also as a potent signalling molecule. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ICAM3_HUMAN, P32942
Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a
ligand for integrin alpha-D/beta-2

Gene Wiki entry for ICAM3


Genomic Views
for ICAM3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ICAM3 gene promoter:
         Pax-3   Sp1   Bach2   Tal-1beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ICAM3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ICAM3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ICAM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3-p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.3-p13.2

ICAM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ICAM3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M010444:  view genomic region     (about GC identifiers)

Start:
 10,444,452 bp from pter      End:
 10,450,499 bp from pter
Size:
 6,048 bases      Orientation:
 minus strand

Proteins
for ICAM3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ICAM3_HUMAN, P32942 (See protein sequence)
Recommended Name: Intercellular adhesion molecule 3 precursor  
Size: 547 amino acids; 59541 Da
Subcellular location: Membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for ICAM3:
1T0P (3D)    
Secondary accessions: Q6PD68

Explore the universe of human proteins at neXtProt for ICAM3: NX_P32942

Post-translational modifications:

  • Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues1
  • N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P32942

    • ICAM3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002153.2  
    ENSEMBL proteins: 
     ENSP00000160262   ENSP00000468230   ENSP00000468333   ENSP00000467232   ENSP00000466501  
     ENSP00000467770   ENSP00000466081   ENSP00000468282  
    Reactome Protein details: P32942
    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for ICAM3 (ICAM-3/CD50)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ICAM3
    OriGene Protein Over-expression Lysate: ICAM3
    OriGene Custom Protein Services for ICAM3 
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    Novus Biologicals ICAM3 Proteins
    Novus Biologicals ICAM3 Lysate
    Sino Biological Recombinant Protein for ICAM3
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ICAM3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8459213


    ICAM3 for ontologies           About GeneDecksing



    ICAM3 Antibody Products: 
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    Uscn ELISAs and CLIAs for ICAM3

    Protein Domains /
    Families
    for ICAM3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ICAM3 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR003988 ICAM
     IPR013768 ICAM_N
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P32942

    ProtoNet protein and cluster: P32942

    4 Blocks protein families:
    IPB003599 Immunoglobulin subtype
    IPB003987 Intercellular adhesion molecule/vascular cell adhesion molecule-1 signature
    IPB003988 Intercellular adhesion molecule (ICAM) family signature
    IPB013768 Intercellular adhesion molecule


    UniProtKB/Swiss-Prot: ICAM3_HUMAN, P32942
    Similarity: Belongs to the immunoglobulin superfamily. ICAM family
    Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains


    Function
    for ICAM3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ICAM3_HUMAN, P32942
    Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a
    ligand for integrin alpha-D/beta-2

         Genatlas biochemistry entry for ICAM3:
    adhesion molecule intercellular 3,ligand for LFA1,counterreceptor,expressed only on the leukocytes interacting with
    moesin and promoting its redistribution to the uropod of T lymphocytes during cell polarization,Ig superfamily

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for ICAM3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICAM3 

    Cell Line
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    Search LifeMap BioReagents cell lines for ICAM3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM3

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS8459213
    GO:0005178integrin binding IPI1448173
    GO:0005515protein binding IPI12082081


    ICAM3 for ontologies           About GeneDecksing



    Pathways & Interactions
    for ICAM3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    2G-protein signaling_Ras family GTPases in kinase cascades (scheme)
    		Immune response Role of integrins in NK cells cytotoxicity0.28
    		Immune response_Role of integrins in NK cells cytotoxicity0.28
    3Cell adhesion molecules (CAMs)
    		Cell adhesion molecules (CAMs)1.00
    4IL-5 Signaling Pathway
    		IL-5 Signaling Pathway1.00
    5Signaling by GPCR
    		Signal Transduction0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ICAM3
        Immune response Role of integrins in NK cells cytotoxicity


    1 GeneGo (Thomson Reuters) Pathway for ICAM3
        Immune response Role of integrins in NK cells cytotoxicity

    1 BioSystems Pathway for ICAM3 
        IL-5 Signaling Pathway

    5        Reactome Pathways for ICAM3
        Integrin cell surface interactions
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Signal Transduction
    Adaptive Immune System
    Immune System


    1         Kegg Pathway  (Kegg details for ICAM3):
        Cell adhesion molecules (CAMs)


    ICAM3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ICAM3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/11 Interacting proteins for ICAM3 (P329422, 3 ENSP000001602624) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZBTB16Q055162, 3, ENSP000003381574MINT-63670 I2D: score=4 STRING: ENSP00000338157
    EZRP153113, ENSP000003389344I2D: score=3 STRING: ENSP00000338934
    ITGB2P051073, ENSP000003032424I2D: score=2 STRING: ENSP00000303242
    PRKCQQ047593, ENSP000002631254I2D: score=2 STRING: ENSP00000263125
    CD209Q9NNX63, ENSP000003154774I2D: score=1 STRING: ENSP00000315477
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016337cell-cell adhesion IEA--
    GO:0050776regulation of immune response TAS--


    ICAM3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ICAM3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ICAM3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ICAM3
    10 Novoseek chemical compound relationships for ICAM3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-formylmethionyl-leucylphenylalanine 38.6 2 10733515 (1), 14723618 (1)
    polysaccharide 16.9 2 15545280 (1), 17145745 (1)
    mannose 16 1 15545280 (1)
    fmlp 12.1 1 14723618 (1)
    rantes 9.47 3 9298994 (2), 9174593 (1)
    phosphatidylinositol 0.949 1 11784723 (1)
    calcium 0 6 9672149 (3), 10688433 (2)
    tyrosine 0 7 7520448 (5)
    carbohydrates 0 1 12234361 (1)
    dexamethasone 0 2 10688433 (1), 8730134 (1)

    Search CenterWatch for drugs/clinical trials and news about ICAM3 

    Transcripts
    for ICAM3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ICAM3 gene: 
    NM_002162.3  

    Unigene Cluster for ICAM3:

    Intercellular adhesion molecule 3
    Hs.654563  [show with all ESTs]
    Unigene Representative Sequence: BC046121
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000589900 ENST00000587992 ENST00000160262(uc002mob.2 uc010dxd.1 uc010xlf.1)
    ENST00000592945 ENST00000589261 ENST00000592439 ENST00000585439 ENST00000590569
    ENST00000589249 ENST00000589580

    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: ICAM3
    OriGene siRNA: ICAM3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ICAM3
    Clone
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    Primer
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    Additional cDNA sequence: 

    AF340060.1 AF340061.1 AK226023.1 AK301071.1 AK309643.1 AK312826.1 BC034409.1 BC040123.1 
    BC046121.1 BC058903.1 S50015.1 X69711.1 X69819.1 

    8 DOTS entries:

    DT.453621  DT.40250724  DT.100786949  DT.99993152  DT.95278145  DT.92049816  DT.92424245  DT.100786951 

    24/529 AceView cDNA sequences (see all 529):

    CK826281 AA341290 BE702352 BM551727 BG257988 BQ062308 BQ430683 BQ271665 
    BE395527 BI255037 BM832369 BM726266 BU183371 BQ446829 BQ086373 BU859475 
    BQ677994 BQ066216 BE883887 CF135584 AA354247 BE257181 BM450446 BM675275 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ICAM3 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
    SP1:                    -                                   -                                       
    SP2:                    -                                                                           
    SP3:                    -                                                                           
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for ICAM3

    Expression
    for ICAM3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ICAM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTAGGGAGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ICAM3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Bone marrow-derived adherent progenitor cells (MultiStem) (Adult Stem / Progenitor Cell)Bone
    CyT49 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ICAM3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ICAM3

    SOURCE GeneReport for Unigene cluster: Hs.654563
        SABiosciences Custom PCR Arrays for ICAM3
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM3

    Orthologs
    for ICAM3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ICAM3 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    ICAM46
    		 --
    		 27(a)
    26(a)
    		 many ↔ many
    many ↔ many
    		 GL344305.1(34371-49910)
    GL343233.1(1353200-1357090)
            Species with no ortholog for ICAM3

    ENSEMBL Gene Tree for ICAM3 (if available)
    TreeFam Gene Tree for ICAM3 (if available) 

    Paralogs
    for ICAM3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ICAM3 gene
    ICAM42  ICAM22  ICAM52  ICAM12  
    5 SIMAP similar genes for ICAM3 using alignment to 9 protein entries:     ICAM3_HUMAN (see all proteins):
    ICAM5    P3.58    ICAM1    ICAM-1    ICAM2

    ICAM3 for paralogs           About GeneDecksing



    Genomic Variants
    for ICAM3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/180 NCBI SNPs in ICAM3 are shown (see all 180)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1150377281,2
    		C,F,--10443961(+) CCCCAA/GTACCT 2 -- int1 ds50011Minor allele frequency- G:0.06WA 118
    rs2007575431,2
    		--10444251(+) GAGGGC/TGCGCC 2 -- ds5001 ut510--------
    rs1483710081,2
    		--10444386(+) CAGCGA/GCGCTA 2 -- ds5001 us2k10--------
    rs2002819171,2
    		--10444507(+) CCCCCA/GCCAAC 2 -- ut31 us2k10--------
    rs1445330701,2
    		C,F,--10444558(+) CTTCCC/ACCATT 3 /G /V us2k1 mis12Minor allele frequency- A:0.00NA EU 5875
    rs22303991,2
    		C,F,H,--10444603(-) GGAGAG/CCACCT 3 /T /S mis1 us2k1 trp327Minor allele frequency- C:0.12MN NA NS EA CSA WA EU 7625
    rs769651801,2
    		C,--10444623(+) TGGTAA/CCTGCC 3 R S mis1 us2k10--------
    rs1997806001,2
    		--10444624(+) GGTAAC/TTGCCG 3 N S us2k1 mis10--------
    rs2014125191,2
    		--10444641(+) TGGTGC/TTCCCT 3 E syn1 us2k10--------
    rs1398511391,2
    		C,F,--10444667(+) GGCCAG/ATACGA 3 /L syn1 us2k11Minor allele frequency- A:0.01NA 4550

    HapMap Linkage Disequilibrium report for ICAM3 (10444452 - 10450499 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ICAM3
         2 CNVs: 29686 29685

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    Disorders / Diseases
    for ICAM3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ICAM3 for disorders           About GeneDecksing

    OMIM gene information: 146631    OMIM disorders: --

    20/43 diseases for ICAM3 (see all 43):    About MalaCards
    tick-borne encephalitis    human t-cell leukemia virus type 1    sars infection    vernal keratoconjunctivitis
    severe acute respiratory syndrome    membranoproliferative glomerulonephritis    inflammatory bowel disease    mycosis fungoides
    keratoconjunctivitis    adult t-cell leukemia    encephalitis    rheumatoid arthritis
    multiple sclerosis    skin disease    ulcerative colitis    colon carcinoma in situ
    t-cell leukemia    glomerulonephritis    colon carcinoma    dermatitis

    10/21 Novoseek disease relationships for ICAM3 gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 36.7 8 11799181 (1), 12477827 (1), 14970226 (1), 16641270 (1) (see all 8)
    inflammation 34.6 3 17701178 (1), 8579109 (1), 16792588 (1)
    asthma allergic 23.1 1 11964048 (1)
    colitis ulcerative 20.1 3 9471026 (1), 9473377 (1), 10931137 (1)
    autoimmune response 16.1 1 7523142 (1)
    dermatitis atopic 9.59 5 8547030 (2)
    psoriasis 5.29 7 8547030 (2), 8721479 (1), 12854881 (1)
    cancer 1.74 8 19956847 (3), 8579109 (1)
    inflammatory bowel diseases 0.626 1 10931137 (1)
    hiv infections 0.307 1 17530994 (1)

    Human Genome Epidemiology (HuGE) Navigator: ICAM3 (13 documents)

    Export disorders for ICAM3 gene to outside databases

    Publications
    for ICAM3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ICAM3 gene, integrated from 9 sources (see all 232):
    (articles sorted by number of sources associating them with ICAM3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a new intercellular adhesion molecule ICAM-R. (PubMed id 1448174)1, 2, 3, 9 Vazeux R.... Gallatin W.M. (1992)
    2. Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes. (PubMed id 1448173)1, 2, 9 Fawcett J.... Simmons D.L. (1992)
    3. Structural study of N-linked oligosaccharides of human intercellular adhesion molecule-3 (CD50). (PubMed id 11179968)1, 2, 9 Funatsu O....Furukawa K. (2001)
    4. An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin alphaLbeta2. (PubMed id 15728350)1, 2 Song G.... Wang J.-H. (2005)
    5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    6. Cloning and expression of intercellular adhesion molecule 3 reveals strong homology to other immunoglobulin family counter-receptors for lymphocyte function-associated antigen 1. (PubMed id 8459213)1, 2 de Fougerolles A.R.... Springer T.A. (1993)
    7. CDw50 and ICAM-3: two names for the same molecule. (PubMed id 8325327)1, 2 Juan M....Springer T.A. (1993)
    8. DC-SIGN binds ICAM-3 isolated from peripheral human leukocytes through Lewis x residues. (PubMed id 17145745)1, 9 Bogoevska V....Wagener C. (2007)
    9. A novel serine-rich motif in the intercellular adhesion molecule 3 is critical for its ezrin/radixin/moesin-directed subcellular targeting. (PubMed id 11784723)1, 9 Serrador J.M....Sanchez-Madrid F. (2002)
    10. ICAM-3 activation modulates cell-cell contacts of human bone marrow endothelial cells. (PubMed id 14726630)1, 9 van Buul J.D....Hordijk P.L. (2004)

    External Searches for ICAM3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing ICAM3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3385 HGNC: 5346 AceView: ICAM3andMGC19604andRAVER1 Ensembl:ENSG00000076662 euGenes: HUgn3385
    ECgene: ICAM3 Kegg: 3385 H-InvDB: ICAM3

    Other Databases showing ICAM3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ICAM3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ICAM3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ICAM3 Genetics and Cytogenetics in Oncology and Haematology
    R&D Systems' cytokine source book: ICAM-3http://www.rndsystems.com/molecule_detail.aspx?m=1589
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_263

    Intellectual Property
    for ICAM3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ICAM3 gene:
    Search GeneIP for patents involving ICAM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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