Aliases for ICAM3 Gene
External Ids for ICAM3 Gene
Previous GeneCards Identifiers for ICAM3 Gene
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]
GeneCards Summary for ICAM3 Gene
ICAM3 (Intercellular Adhesion Molecule 3) is a Protein Coding gene. Diseases associated with ICAM3 include relapsing-remitting multiple sclerosis and trichosporonosis. Among its related pathways are Cell adhesion molecules (CAMs) and Immune System. GO annotations related to this gene include receptor binding and integrin binding. An important paralog of this gene is ICAM1.
UniProtKB/Swiss-Prot for ICAM3 Gene
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2.