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Aliases for ICAM2 Gene

Aliases for ICAM2 Gene

  • Intercellular Adhesion Molecule 2 2 3
  • ICAM-2 3 4
  • CD102 Antigen 4
  • CD102 3

External Ids for ICAM2 Gene

Previous GeneCards Identifiers for ICAM2 Gene

  • GC17M061717
  • GC17M064506
  • GC17M062420
  • GC17M062553
  • GC17M059433
  • GC17M062079
  • GC17M057447

Summaries for ICAM2 Gene

Entrez Gene Summary for ICAM2 Gene

  • The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ICAM2 Gene

ICAM2 (Intercellular Adhesion Molecule 2) is a Protein Coding gene. Diseases associated with ICAM2 include polyarteritis nodosa. Among its related pathways are Class I MHC mediated antigen processing and presentation and Integrin Pathway. GO annotations related to this gene include integrin binding. An important paralog of this gene is ICAM1.

UniProtKB/Swiss-Prot for ICAM2 Gene

  • ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance

Gene Wiki entry for ICAM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICAM2 Gene

Genomics for ICAM2 Gene

Regulatory Elements for ICAM2 Gene

Genomic Location for ICAM2 Gene

Start:
64,002,594 bp from pter
End:
64,020,634 bp from pter
Size:
18,041 bases
Orientation:
Minus strand

Genomic View for ICAM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ICAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICAM2 Gene

Proteins for ICAM2 Gene

  • Protein details for ICAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13598-ICAM2_HUMAN
    Recommended name:
    Intercellular adhesion molecule 2
    Protein Accession:
    P13598
    Secondary Accessions:
    • Q14600

    Protein attributes for ICAM2 Gene

    Size:
    275 amino acids
    Molecular mass:
    30654 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ICAM2 Gene

neXtProt entry for ICAM2 Gene

Proteomics data for ICAM2 Gene at MOPED

Post-translational modifications for ICAM2 Gene

  • Ubiquitination at Lys128
  • Glycosylation at Asn47, Asn82, Asn105, Asn153, Asn176, and Asn187
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ICAM2 (ICAM2)

Protein Products

No data available for DME Specific Peptides for ICAM2 Gene

Domains for ICAM2 Gene

Gene Families for ICAM2 Gene

HGNC:
  • CD :CD molecules
  • ENDOLIG :Endogenous ligands
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Graphical View of Domain Structure for InterPro Entry

P13598

UniProtKB/Swiss-Prot:

ICAM2_HUMAN :
  • P13598
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. ICAM family.
genes like me logo Genes that share domains with ICAM2: view

Function for ICAM2 Gene

Molecular function for ICAM2 Gene

GENATLAS Biochemistry:
adhesion molecule,intercellular 2,ligand for (LFA1,CD11A/CD18),expressed in resting lymphocyte,monocyte,platelet,vascular endothelium,redistributed by ezrin (VIL2) as a target for killer cells,also interacting with ICAM1 and VIL2 in microvillar projections,under phosphatidylinositol-4,5 biphosphate regulation,Ig superfamily
UniProtKB/Swiss-Prot Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance

Gene Ontology (GO) - Molecular Function for ICAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IPI 1448173
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ICAM2: view
genes like me logo Genes that share phenotypes with ICAM2: view

Animal Models for ICAM2 Gene

MGI Knock Outs for ICAM2:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ICAM2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ICAM2 Gene

Localization for ICAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICAM2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ICAM2 Gene COMPARTMENTS Subcellular localization image for ICAM2 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 2
extracellular 2
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ICAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001931 uropod IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ICAM2: view

Pathways for ICAM2 Gene

genes like me logo Genes that share pathways with ICAM2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for ICAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0007155 cell adhesion IBA --
GO:0016337 single organismal cell-cell adhesion IEA --
GO:0030198 extracellular matrix organization TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with ICAM2: view

Compounds for ICAM2 Gene

(7) Novoseek inferred chemical compound relationships for ICAM2 Gene

Compound -log(P) Hits PubMed IDs
rantes 7.24 1
calcium 0 1
tyrosine 0 3
glutamate 0 1
polysaccharide 0 3
genes like me logo Genes that share compounds with ICAM2: view

Transcripts for ICAM2 Gene

Unigene Clusters for ICAM2 Gene

Intercellular adhesion molecule 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ICAM2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ICAM2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5
SP1:
SP2: - - -
SP3: - - - -
SP4: -

Relevant External Links for ICAM2 Gene

GeneLoc Exon Structure for
ICAM2
ECgene alternative splicing isoforms for
ICAM2

Expression for ICAM2 Gene

mRNA expression in normal human tissues for ICAM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ICAM2 Gene

This gene is overexpressed in Whole Blood (5.8) and Spleen (5.1).

Protein differential expression in normal tissues for ICAM2 Gene

This gene is overexpressed in Serum (35.4), Peripheral blood mononuclear cells (6.6), and Plasma (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ICAM2 Gene

SOURCE GeneReport for Unigene cluster for ICAM2 Gene Hs.431460

genes like me logo Genes that share expressions with ICAM2: view

Expression partners for ICAM2 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ICAM2 Gene

Orthologs for ICAM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ICAM2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC616254 35
  • 65.56 (n)
  • 51.85 (a)
ICAM2 36
  • 52 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ICAM2 35
  • 70.26 (n)
  • 58.08 (a)
ICAM2 36
  • 53 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Icam2 35
  • 71.71 (n)
  • 60.89 (a)
Icam2 16
Icam2 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ICAM2 35
  • 99.39 (n)
  • 98.18 (a)
ICAM2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Icam2 35
  • 68.74 (n)
  • 56.41 (a)
oppossum
(Monodelphis domestica)
Mammalia ICAM2 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 10 (a)
ManyToMany
-- 36
  • 11 (a)
ManyToMany
Species with no ortholog for ICAM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ICAM2 Gene

ENSEMBL:
Gene Tree for ICAM2 (if available)
TreeFam:
Gene Tree for ICAM2 (if available)

Paralogs for ICAM2 Gene

Paralogs for ICAM2 Gene

Selected SIMAP similar genes for ICAM2 Gene using alignment to 10 proteins:

Pseudogenes.org Pseudogenes for ICAM2 Gene

genes like me logo Genes that share paralogs with ICAM2: view

Variants for ICAM2 Gene

Sequence variations from dbSNP and Humsavar for ICAM2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs5502 -- 64,006,680(-) TCTTT(C/T)GGTTA reference, synonymous-codon
rs5503 - 64,005,326(-) AGCTG(A/G)CGGTT missense, reference
rs917556 -- 64,020,132(+) CCTGC(C/T)GGGGA intron-variant
rs1051187 -- 64,006,694(-) TGCCA(G/T)AGATG utr-variant-5-prime
rs2079771 -- 64,012,181(+) atacT(A/G)gccag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ICAM2 Gene

Variant ID Type Subtype PubMed ID
nsv517272 CNV Gain+Loss 19592680
nsv833511 CNV Loss 17160897
nsv908684 CNV Loss 21882294
nsv908685 CNV Loss 21882294

Relevant External Links for ICAM2 Gene

HapMap Linkage Disequilibrium report
ICAM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICAM2 Gene

Disorders for ICAM2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ICAM2 Gene in MalaCards »

(1) Diseases for ICAM2 Gene including...

(20) Novoseek inferred disease relationships for ICAM2 Gene

Disease -log(P) Hits PubMed IDs
inflammation 29.8 5
necrosis 23.1 2
immunodeficiency 22.5 4
rheumatoid arthritis 14.5 1
tumors 14.4 8

Relevant External Links for ICAM2

Genetic Association Database (GAD)
ICAM2
Human Genome Epidemiology (HuGE) Navigator
ICAM2
genes like me logo Genes that share disorders with ICAM2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for ICAM2 Gene

Publications for ICAM2 Gene

  1. The human ICAM2 gene maps to 17q23-25. (PMID: 1769660) Sansom D. … Trowsdale J. (Genomics 1991) 2 3 23
  2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4
  3. Expression of human intercellular adhesion molecules in middle ear cholesteatoma. (PMID: 7526720) BujA-a J. … Kastenbauer E. (Am J Otolaryngol 1994) 3 23
  4. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 48
  5. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 48

Products for ICAM2 Gene

  • Addgene plasmids for ICAM2

Sources for ICAM2 Gene

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