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ICAM2 Gene

protein-coding GIFtS: 63

GC17M059433

intercellular adhesion molecule 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CD102 ^¹, ²
ICAM-2 ^³

Descriptions
CD102 antigen ^³
intercellular adhesion molecule 2 ^²

External Ids
HGNC: 5345¹
Entrez Gene: 3384²
UniProtKB: P13598³
Ensembl: ENSG00000108622⁷

Search outside databases for aliases for ICAM2 gene

Previous GC identifers: GC17M061717 GC17M064506 GC17M062420 GC17M062553

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ICAM2:

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family.

All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type

domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in

lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive

interactions important for antigen-specific immune response, NK-cell mediated clearance,

lymphocyte recirculation, and other cellular interactions important for immune response and

surveillance. Several transcript variants encoding the same protein have been found for this gene.

[provided by RefSeq]

UniProtKB/Swiss-Prot: ICAM2_HUMAN, P13598

Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin

alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent

cell adhesion. It mediates adhesive interactions important for antigen-specific immune response,

NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important

for immune response and surveillance

Gene Wiki entry for ICAM2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ICAM2 gene

Entrez Gene cytogenetic band: 17q23-q25 Ensembl cytogenetic band: 17q23.3 HGNC cytogenetic band: 17q23-q25

ICAM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M059433: (about GC identifiers)

Start:	59,433,687 bp from pter
End:	59,451,726 bp from pter
Size:	18,040 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010783.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ICAM2_HUMAN, P13598 (See protein sequence)

Recommended Name: Intercellular adhesion molecule 2 precursor

Size: 275 amino acids; 30654 Da

Subcellular location: Membrane; Single-pass type I membrane protein

PDB structures from and Proteopedia :

1ZXQ (3D)

Secondary accessions: Q14600

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (5 alternative transcripts):

NP_000864.2 NP_001093256.1 NP_001093257.1 NP_001093258.1 NP_001093259.1

ENSEMBL proteins:

ENSP00000225760

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for ICAM2 (ICAM-2/CD102)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ICAM2)
	Human Recombinant Proteins from Abnova (ICAM2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	2497351
GO:0005887	integral to plasma membrane	TAS	2497351

About this table

Antibodies for ICAM2:

	Invitrogen Antibodies for ICAM2
	Millipore Mono- and Polyclonal Antibodies for the study of ICAM2
	Sigma-Aldrich Antibodies for ICAM2
	R&D Systems Antibodies for ICAM2 (ICAM-2/CD102)
	Antibodies from Abcam (ICAM2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ICAM2)
	Novus Biologicals Antibodies for ICAM2

Assays for ICAM2:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of ICAM2
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P13598

ProtoNet protein and cluster: P13598

3 Blocks protein families:

IPB003987 Intercellular adhesion molecule/vascular cell adhesion molecule-1 signature

IPB003988 Intercellular adhesion molecule (ICAM) family signature

IPB013768 Intercellular adhesion molecule

UniProtKB/Swiss-Prot: ICAM2_HUMAN, P13598

Similarity: Belongs to the immunoglobulin superfamily. ICAM family

Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ICAM2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_001099786

Applied Biosystems Silencer® siRNAs for ICAM2

Sigma-Aldrich siRNA and siRNA Panels for ICAM2

Sigma-Aldrich shRNA Panels and shRNA for ICAM2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ICAM2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_000873
Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_000873
untagged cDNA clones in CMV expression vector (see all 5): NM_000873

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001099788

UniProtKB/Swiss-Prot: ICAM2_HUMAN, P13598

Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin

alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent

cell adhesion. It mediates adhesive interactions important for antigen-specific immune response,

NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important

for immune response and surveillance

Genatlas biochemistry entry for ICAM2:

adhesion molecule,intercellular 2,ligand for (LFA1,CD11A/CD18),expressed in resting

lymphocyte,monocyte,platelet,vascular endothelium,redistributed by ezrin (VIL2) as a target for

killer cells,also interacting with ICAM1 and VIL2 in microvillar projections,under

phosphatidylinositol-4,5 biphosphate regulation,Ig superfamily

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Icam2):

hematopoietic system

immune system

respiratory system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005178	integrin binding	TAS	2497351
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for ICAM2

5/41 Interacting proteins for ICAM2 (ENSP00000225760³) via UniProtKB, MINT, and/or STRING (see all 41 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ITGAL	ENSP00000349252³	STRING (score=.996)
ITGB2	ENSP00000347279³	STRING (score=.996)
ITGAM	ENSP00000287497³	STRING (score=.992)
MSN	ENSP00000353408³	STRING (score=.971)
ICAM4	ENSP00000342114³	STRING (score=.926)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016337	cell-cell adhesion	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ICAM2
3 Novoseek chemical compound relationships for ICAM2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	8.39	1	11869363 (1)
calcium	0.00	1	10688433 (1)
tyrosine	0.00	3	11472628 (1), 11463761 (1), 11825565 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ICAM2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_001099786

Sigma-Aldrich siRNA and siRNA Panels for ICAM2

Sigma-Aldrich shRNA Panels and shRNA for ICAM2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000873 NM_001099786 NM_001099787 NM_001099788 NM_001099789

REFSEQ mRNAs for ICAM2 gene (5 alternative transcripts):

NM_000873.3 NM_001099786.1 NM_001099787.1 NM_001099788.1 NM_001099789.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000873 NM_001099786 NM_001099787 NM_001099788 NM_001099789

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_000873
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_000873
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_000873

Additional cDNA sequence:

AB209878.1 AF340052.1 AF340053.1 AK223219.1 AK293110.1 AK295382.1 AK309953.1 BC003097.1

CR541812.1 CR541834.1 CR596124.1 CR599245.1 CR599573.1 CR599930.1 CR600674.1 CR615927.1

CR621141.1 X15606.1

11 DOTS entries:

DT.455933 DT.91995331 DT.101984915 DT.100795618 DT.101984913 DT.95280474 DT.92425823 DT.92425828

DT.97775460 DT.95249996 DT.97846486

24/218 AceView cDNA sequences (see all 218 ):

BC003097 BE261894 CA419028 BX355347 CR541812 CR541834 AI167668 CB530017

BU181068 BF794588 BX444203 BU633462 CR621141 BM918998 T27750 BX378501

BE269543 BQ001423 BX363874 AI376349 BM852307 CR599573 CD014037 BM708260

highest scoring ESTs for ICAM2:

X15606 AA062949 AA186978 BC003097 BE260730 BF206397 BF206987 BI199286 BI771250 BM547059

Unigene Cluster for ICAM2:

Intercellular adhesion molecule 2

Hs.431460 [show with all ESTs]

Unigene Representative Sequence: BQ214437

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ICAM2

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	^	5
SP1:
SP2:			-		-						-
SP3:			-		-		-				-
SP4:											-

About this scheme

ECgene alternative splicing isoforms for ICAM2

1 Ensembl transcript including schematic representation:

ENST00000225760

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ICAM2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ICAM2

¹ / ² / ³

7 probe-sets matching ICAM2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38454_g_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.97	X15606	1.00	1.00	1.00	1
590_at²^{, 3}	U95-A	1	1.00	1.00	0.99	1.04	M32334	0.20	1.00	0.72	1
38453_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.99	X15606	1.00	1.00	1.00	1
213620_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA126728	0.40	0.67	0.55	1
204683_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000873	0.60	1.00	0.82	1
213620_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204683_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ICAM2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCCACCACCA

SOURCE GeneReport for Unigene cluster: Hs.431460
Expression variation in blood from EXPOLDB for ICAM2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ICAM2 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ICAM2¹	--	intercellular adhesion molecule 2	71.31(n) 59.76(a)	480475 XM_537594.2 XP_537594.2
chimpanzee (Pan troglodytes)	ICAM2¹	--	intercellular adhesion molecule 2	99.39(n) 98.18(a)	494137 NM_001009166.1 NP_001009166.1
cow (Bos taurus)	ICAM2¹	--	intercellular adhesion molecule 2	65.56(n) 51.48(a)	506088 XM_582483.3 XP_582483.3
rat (Rattus norvegicus)	Icam2¹	--	intercellular adhesion molecule 2	68.62(n) 56.41(a)	360647 NM_001007725.1 NP_001007726.1
mouse (Mus musculus)	Icam2^{1, 5}	11 (63.00 cM)⁵	intercellular adhesion molecule 2^{1, 5}	71.71(n)¹ 60.89(a)¹	15896¹ NM_010494.1¹ NP_034624.1¹ AK007801⁵ AL604045⁵ (see all 12)

About this table Species with no ortholog for ICAM2

ENSEMBL Gene Tree for ICAM2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ICAM2 gene

ICAM5² ICAM1² ICAM3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/145 NCBI SNPs in ICAM2 are shown (see all 145 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 40)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7219518^1,2	A,C,F,H	59438185(+)	`GACAAC/GCATCC`	5	--	int¹ ng3¹		8		EU EA WA	838
--	rs7223925^1,2	A,C,H	59453056(+)	`aggcaT/Cgtgcc`	4	--	ng3¹ tfbs³		4		EU EA WA	408
--	rs5503^1,2	C,F,O	59436418(-)	`AGCTGG/ACGGTT`	5	T/A	mis¹		10		MN EU EA WA NA	852
	rs9910969^1,2	F,H	59438832(+)	`GCCTAC/TCTGAT`	5	--	int¹ ng3¹		4		EU EA WA	420
	rs9891300^1,2	F,H	59439755(+)	`AGCCCG/ACCCGA`	5	--	int¹ ng3¹		4		EU EA WA	420
--	rs8081366^1,2	A,H	59453725(+)	`CAGTTC/GCAGGA`	4	--	ng3¹ tfbs³		4		EU EA WA	416
--	rs7218499^1,2	A,C	59452113(+)	`ttcctC/Tggcct`	4	--	ng3¹		0	--	--	--	--
	rs9891419^1,2	F,H	59439986(+)	`CTCTTC/GAAGCA`	5	--	ng3¹ int¹ trp³		4		EU EA WA	420
--	rs16947352^1,2	F	59451578(-)	`GAAGCG/ATGGCA`	4	--	ut5¹ int¹		6		MN EA NA	718
--	rs11656728^1,2	C	59451954(+)	`cctccC/Tgagtt`	4	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for ICAM2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 146630

10/20 Novoseek disease relationships for ICAM2 gene (see all 20 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	31.78	5	10223354 (2), 8083366 (1), 17701178 (1), 9863370 (1)
necrosis	24.46	2	11719371 (1), 10574717 (1)
immunodeficiency	23.45	4	12477827 (1), 14970226 (1), 12122001 (1), 19211748 (1)
tumors	14.74	8	18978946 (3), 1348028 (2), 8604238 (1), 8922057 (1) (see all 5)
colitis ulcerative	12.01	2	9473377 (1), 10931137 (1)
rheumatoid arthritis	11.47	1	8394794 (1)
senile plaques	4.95	1	7904796 (1)
cancer	3.38	2	14999228 (1), 15269165 (1)
colon carcinoma	1.60	2	11169447 (1)
inflammatory bowel diseases	0.13	1	10931137 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/212 PubMed articles for ICAM2 gene (see all 212 ):

The human ICAM2 gene maps to 17q23-25. (PubMed id 1769660)^{1, 2, 3} Sansom D....Trowsdale J. (1991)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{3, 4} Liu T.... Smith R.D. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface. (PubMed id 9153399)^{3, 4} Casasnovas J.M.... Wang J.-H. (1997)
Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1. (PubMed id 2497351)^{3, 4} Staunton D.E.... Springer T.A. (1989)
Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1. (PubMed id 1676048)^{1, 3} de Fougerolles A.R....Springer T.A. (1991)
Towards endothelial cell-specific transgene expression in pigs: characterization of the pig ICAM-2 promoter. (PubMed id 17059578)^{1, 3} Godwin J.W....Cowan P.J. (2006)
Expression of intercellular adhesion molecules ICAM-1 and ICAM-2 in human endometrium: regulation by interferon-gamma. (PubMed id 10050664)^{1, 3} Thomson A.J....Campbell S. (1999)
Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium. (PubMed id 18842965)^{1, 3} Porter J.C. and Hall A. (2009)
DC-SIGN binds to HIV-1 glycoprotein 120 in a distinct but overlapping fashion compared with ICAM-2 and ICAM-3. (PubMed id 14970226)^{1, 3} Su S.V....Lee B. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3384	HGNC: 5345	AceView: ICAM2	Ensembl:ENSG00000108622	euGenes: HUgn3384
ECgene: ICAM2	H-InvDB: ICAM2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ICAM2	Genetics and Cytogenetics in Oncology and Haematology
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_262

Licensable Technologies for ICAM2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ICAM2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ICAM2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ICAM2		Antibodies for ICAM2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ICAM2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search Tocris compounds for ICAM2

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Antibodies for ICAM2

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ICAM2 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for ICAM2

Summaries
for ICAM2

Genomic Location
for ICAM2

Proteins
for ICAM2

Protein Domains/
Families
for ICAM2

Gene Function
for ICAM2

Pathways & Interactions
for ICAM2

Drugs & Compounds
for ICAM2

Transcripts
for ICAM2

Expression
for ICAM2

Orthologs
for ICAM2

Paralogs
for ICAM2

SNPs/Variants
for ICAM2

Disorders & Mutations
for ICAM2

Medical News
for ICAM2

Publications
for ICAM2

Search for ICAM2

Genome Databases showing ICAM2

Other Databases showing ICAM2

Specialized Databases showing ICAM2

Licensable Technologies
for ICAM2

Services
for ICAM2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ICAM2 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor ICAM2

Summariesfor ICAM2

Genomic Locationfor ICAM2

Proteinsfor ICAM2

Protein Domains/Familiesfor ICAM2

Gene Functionfor ICAM2

Pathways & Interactionsfor ICAM2

Drugs & Compoundsfor ICAM2

Transcriptsfor ICAM2

Expression for ICAM2

Orthologsfor ICAM2

Paralogsfor ICAM2

SNPs/Variantsfor ICAM2

Disorders & Mutationsfor ICAM2

Medical Newsfor ICAM2

Publicationsfor ICAM2

Search for ICAM2

Genome Databases showing ICAM2

Other Databases showing ICAM2

Specialized Databases showing ICAM2

Licensable Technologiesfor ICAM2

Servicesfor ICAM2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ICAM2

Summaries
for ICAM2

Genomic Location
for ICAM2

Proteins
for ICAM2

Protein Domains/
Families
for ICAM2

Gene Function
for ICAM2

Pathways & Interactions
for ICAM2

Drugs & Compounds
for ICAM2

Transcripts
for ICAM2

Expression
for ICAM2

Orthologs
for ICAM2

Paralogs
for ICAM2

SNPs/Variants
for ICAM2

Disorders & Mutations
for ICAM2

Medical News
for ICAM2

Publications
for ICAM2

Licensable Technologies
for ICAM2

Services
for ICAM2