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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ICAM2 Gene

protein-coding   GIFtS: 61
GCID: GC17M062079

intercellular adhesion molecule 2
 Explore 43 diseases affiliated with
ICAM2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ICAM2    

Aliases
for ICAM2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Intercellular Adhesion Molecule 21 2
CD1021 2
ICAM-22 3
CD102 Antigen3

External Ids:    HGNC: 53451   Entrez Gene: 33842   Ensembl: ENSG000001086227   OMIM: 1466305   UniProtKB: P135983   

Export aliases for ICAM2 gene to outside databases

Previous GC identifers: GC17M061717 GC17M064506 GC17M062420 GC17M062553 GC17M059433 GC17M057447


Summaries
for ICAM2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ICAM2:
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins
are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte
adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell
adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated
clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
Several transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ICAM2_HUMAN, P13598
Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play
a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions
important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other
cellular interactions important for immune response and surveillance

Gene Wiki entry for ICAM2


Genomic Views
for ICAM2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ICAM2 gene promoter:
         HOXA9   HOXA9B   Sox5   Meis-1b   AREB6   Meis-1a   MRF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ICAM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ICAM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ICAM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.3   Ensembl cytogenetic band:  17q23.3   HGNC cytogenetic band: 17q23.3

ICAM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ICAM2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M062079:  view genomic region     (about GC identifiers)

Start:
 62,079,954 bp from pter      End:
 62,097,994 bp from pter
Size:
 18,041 bases      Orientation:
 minus strand

Proteins
for ICAM2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ICAM2_HUMAN, P13598 (See protein sequence)
Recommended Name: Intercellular adhesion molecule 2 precursor  
Size: 275 amino acids; 30654 Da
Subcellular location: Membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for ICAM2:
1ZXQ (3D)    
Secondary accessions: Q14600

Explore the universe of human proteins at neXtProt for ICAM2: NX_P13598

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P13598

    • ICAM2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_000864.2  NP_001093256.1  NP_001093257.1  NP_001093258.1  NP_001093259.1  

    ENSEMBL proteins: 
     ENSP00000463199   ENSP00000462617   ENSP00000464372   ENSP00000392634   ENSP00000464665  
     ENSP00000462579   ENSP00000464331   ENSP00000463945   ENSP00000463862   ENSP00000415283  
     ENSP00000388666  
    Reactome Protein details: P13598
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ICAM2 (ICAM-2/CD102)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ICAM2
    OriGene Protein Over-expression Lysate (see all 9): ICAM2
    OriGene Custom Protein Services for ICAM2 
    GenScript Custom Purified and Recombinant Proteins Services for ICAM2
    Novus Biologicals ICAM2 Proteins
    Novus Biologicals ICAM2 Lysates
    Sino Biological Recombinant Protein for ICAM2
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ICAM2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001931uropod IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IEA--
    GO:0071944cell periphery ----


    ICAM2 for ontologies           About GeneDecksing



    ICAM2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ICAM2
    R&D Systems Antibodies for ICAM2 (ICAM-2/CD102)
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    Novus Biologicals ICAM2 Antibodies
    Search for Antibodies for ICAM2 at Abcam  
    Uscn Antibodies for ICAM2
    ThermoFisher Antibodies for ICAM2

    Assay Products for ICAM2: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for ICAM2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ICAM2

    Protein Domains /
    Families
    for ICAM2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ICAM2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR015653 ICAM2
     IPR003988 ICAM
     IPR013768 ICAM_N
     IPR013783 Ig-like_fold
     IPR003987 ICAM_VCAM_N

    Graphical View of Domain Structure for InterPro Entry P13598

    ProtoNet protein and cluster: P13598

    3 Blocks protein families:
    IPB003987 Intercellular adhesion molecule/vascular cell adhesion molecule-1 signature
    IPB003988 Intercellular adhesion molecule (ICAM) family signature
    IPB013768 Intercellular adhesion molecule


    UniProtKB/Swiss-Prot: ICAM2_HUMAN, P13598
    Similarity: Belongs to the immunoglobulin superfamily. ICAM family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    Function
    for ICAM2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ICAM2_HUMAN, P13598
    Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play
    a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions
    important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other
    cellular interactions important for immune response and surveillance

         Genatlas biochemistry entry for ICAM2:
    adhesion molecule,intercellular 2,ligand for (LFA1,CD11A/CD18),expressed in resting
    lymphocyte,monocyte,platelet,vascular endothelium,redistributed by ezrin (VIL2) as a target for killer cells,also
    interacting with ICAM1 and VIL2 in microvillar projections,under phosphatidylinositol-4,5 biphosphate regulation,Ig
    superfamily

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ICAM2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ICAM2:
    hsa-miR-3934 hsa-miR-3157-5p
    SwitchGear 3'UTR luciferase reporter plasmid: ICAM2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ICAM2 (see all 7)
    OriGene shRNA RFP: ICAM2
    OriGene siRNA: ICAM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ICAM2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ICAM2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ICAM2 (see all 7)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ICAM2 (see all 5)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): ICAM2 (NM_000873)
    Sino Biological Human cDNA Clone for ICAM2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ICAM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICAM2 

    Cell Line
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    Search LifeMap BioReagents cell lines for ICAM2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM2

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding IPI1448173


    ICAM2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Icam2tm1Jcgr for ICAM2
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Icam2):
     hematopoietic system  immune system  respiratory system 

    ICAM2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ICAM2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    2G-protein signaling_Ras family GTPases in kinase cascades (scheme)
    		Immune response Role of integrins in NK cells cytotoxicity0.28
    		Immune response_Role of integrins in NK cells cytotoxicity0.28
    3amb2 Integrin signaling
    		amb2 Integrin signaling1.00
    4Natural killer cell mediated cytotoxicity
    		Natural killer cell mediated cytotoxicity1.00
    5Cell adhesion molecules (CAMs)
    		Cell adhesion molecules (CAMs)1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ICAM2
        Immune response Role of integrins in NK cells cytotoxicity

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ICAM2
        Transendothelial Migration of Leukocytes

    1 GeneGo (Thomson Reuters) Pathway for ICAM2
        Immune response Role of integrins in NK cells cytotoxicity

    1 BioSystems Pathway for ICAM2 
        amb2 Integrin signaling

    5        Reactome Pathways for ICAM2
        Integrin cell surface interactions
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Signal Transduction
    Adaptive Immune System
    Immune System


    2         Kegg Pathways  (Kegg details for ICAM2):
        Cell adhesion molecules (CAMs)
    Natural killer cell mediated cytotoxicity


    ICAM2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ICAM2

    5/6 Interacting proteins for ICAM2 (P135983) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RDXP352413I2D: score=5 
    EZRP153113I2D: score=4 
    MSNP260383I2D: score=3 
    ITGB2P051073I2D: score=2 
    CD209Q9NNX63I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016337cell-cell adhesion IEA--
    GO:0050776regulation of immune response TAS--


    ICAM2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ICAM2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ICAM2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ICAM2
    7 Novoseek chemical compound relationships for ICAM2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 7.24 1 11869363 (1)
    calcium 0 1 10688433 (1)
    tyrosine 0 3 11472628 (1), 11463761 (1), 11825565 (1)
    glutamate 0 1 9700512 (1)
    polysaccharide 0 3 18155766 (2), 15545280 (1)
    5fluorouracil 0 1 10362102 (1)
    serine 0 1 16857989 (1)

    Search CenterWatch for drugs/clinical trials and news about ICAM2 

    Transcripts
    for ICAM2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ICAM2 gene (5 alternative transcripts): 
    NM_000873.3  NM_001099786.1  NM_001099787.1  NM_001099788.1  NM_001099789.1  

    Unigene Cluster for ICAM2:

    Intercellular adhesion molecule 2
    Hs.431460  [show with all ESTs]
    Unigene Representative Sequence: BQ214437
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000578379 ENST00000583684 ENST00000578892 ENST00000449662(uc002jdu.4)
    ENST00000579788 ENST00000581417 ENST00000579687 ENST00000578313 ENST00000583366
    ENST00000584084 ENST00000584403 ENST00000580011(uc010wpx.1) ENST00000580389
    ENST00000583186 ENST00000412356(uc002jdw.4 uc010ded.3) ENST00000418105(uc002jdx.4 uc002jdv.4)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ICAM2
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ICAM2:
    hsa-miR-3934 hsa-miR-3157-5p
    SwitchGear 3'UTR luciferase reporter plasmid: ICAM2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ICAM2 (see all 7)
    OriGene shRNA RFP: ICAM2
    OriGene siRNA: ICAM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ICAM2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ICAM2 (see all 7)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): ICAM2 (NM_000873)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ICAM2

    Additional cDNA sequence: 

    AB209878.1 AF340052.1 AF340053.1 AK223219.1 AK293110.1 AK295382.1 AK309953.1 BC003097.1 
    CR541812.1 CR541834.1 X15606.1 

    11 DOTS entries:

    DT.455933  DT.91995331  DT.101984915  DT.100795618  DT.101984913  DT.95280474  DT.92425823  DT.92425828 
    DT.97775460  DT.95249996  DT.97846486 

    24/218 AceView cDNA sequences (see all 218):

    BU633462 CD014034 BQ271560 BE261894 CR615927 AI141055 BQ709781 CB530017 
    BX444203 BC003097 BU181068 CR541834 AA384615 BP340063 BQ001423 BE269543 
    CR600674 CD014035 BM695682 AI167668 BM918998 NM_000873 BI837883 CR599245 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ICAM2    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5
    SP1:                                                      
    SP2:        -     -                 -                     
    SP3:        -     -     -           -                     
    SP4:                                -                     


    ECgene alternative splicing isoforms for ICAM2

    Expression
    for ICAM2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ICAM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCACCACCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ICAM2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartPrimitive Heart TubePrimitive Heart Tube CellsMyocardium
    HeartHeart TubeHeart
    KidneyS-shaped BodyKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    Human umbilical vein endothelial cells (HUVEC) (Primary Cell)Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium

    See ICAM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ICAM2

    SOURCE GeneReport for Unigene cluster: Hs.431460
        SABiosciences Expression via Pathway-Focused PCR Arrays including ICAM2: 
              Cell Surface Markers in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ICAM2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM2

    Orthologs
    for ICAM2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ICAM2 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia ICAM46
    --
    		 --
    		 8(a)
    12(a)
    		 many ↔ many
    many ↔ many
    		 GL343233.1(1353200-1357090)
    GL344305.1(34371-49910)


    ENSEMBL Gene Tree for ICAM2 (if available)
    TreeFam Gene Tree for ICAM2 (if available) 

    Paralogs
    for ICAM2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ICAM2 gene
    ICAM42  ICAM52  ICAM12  ICAM32  
    3 SIMAP similar genes for ICAM2 using alignment to 10 protein entries:     ICAM2_HUMAN (see all proteins):
    ICAM-1    ICAM3    P3.58

    ICAM2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ICAM2
    PGOHUM00000262989


    Genomic Variants
    for ICAM2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/385 NCBI SNPs in ICAM2 are shown (see all 385)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1920816871,2
    		--62079565(+) CTGGAA/GGGGCC 9 -- ut31 ds50010--------
    rs1838366231,2
    		--62079567(+) GGAGGA/GGCCCA 9 -- ut31 ds50010--------
    rs1394006441,2
    		C,--62079591(+) GAGAC-/TTTGCTG 9 -- ds5001 ut310--------
    rs1475141091,2
    		--62079642(+) ACCCCG/TCATCC 9 -- ds5001 ut310--------
    rs1121885121,2
    		--62079763(+) CTGGGC/TCAGGG 9 -- ut31 ds50011Minor allele frequency- T:0.50CSA 2
    rs1511047901,2
    		--62079768(+) CCAGGG/TTGTGT 9 -- ut31 ds50010--------
    rs1872226041,2
    		--62079847(+) GGCCCC/TTGTGA 9 -- ut31 ds50010--------
    rs1910524381,2
    		--62079902(+) TGGTGG/TCTCCC 9 -- ut31 ds50010--------
    rs1821655081,2
    		--62079946(+) TGTGGA/GCACAG 9 -- ut31 ds50010--------
    rs48861,2
    		C,F,--62080113(-) TTCCGG/ACCATA 14 /R syn1 ut31 ese35Minor allele frequency- A:0.02MN NA WA 4730

    HapMap Linkage Disequilibrium report for ICAM2 (62079954 - 62097994 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ICAM2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ICAM2
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    Disorders / Diseases
    for ICAM2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ICAM2 for disorders           About GeneDecksing

    OMIM gene information: 146630    OMIM disorders: --

    20/43 diseases for ICAM2 (see all 43):    About MalaCards
    tick-borne encephalitis    middle ear cholesteatoma    human t-cell leukemia virus type 1    polyarteritis nodosa
    pre-eclampsia    hemorrhagic fever    inflammatory bowel disease    hemorrhagic fever with renal syndrome
    idiopathic pulmonary fibrosis    cholesteatoma    pulmonary fibrosis    encephalitis
    rheumatoid arthritis    multiple sclerosis    burkitt's lymphoma    colon carcinoma
    colon carcinoma in situ    ulcerative colitis    hemangioblastoma    renal cell carcinoma

    10/20 Novoseek disease relationships for ICAM2 gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 29.8 5 10223354 (2), 8083366 (1), 17701178 (1), 9863370 (1)
    necrosis 23.1 2 11719371 (1), 10574717 (1)
    immunodeficiency 22.5 4 12477827 (1), 14970226 (1), 12122001 (1), 19211748 (1)
    rheumatoid arthritis 14.5 1 8394794 (1)
    tumors 14.4 8 18978946 (3), 1348028 (2), 8604238 (1), 8922057 (1) (see all 5)
    colitis ulcerative 10.5 2 9473377 (1), 10931137 (1)
    lymphoma 7.39 1 8648141 (1)
    senile plaques 3.53 1 7904796 (1)
    cancer 3.19 2 14999228 (1), 15269165 (1)
    colon carcinoma 0.496 2 11169447 (1)

    Human Genome Epidemiology (HuGE) Navigator: ICAM2 (5 documents)

    Export disorders for ICAM2 gene to outside databases

    Publications
    for ICAM2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ICAM2 gene, integrated from 9 sources (see all 229):
    (articles sorted by number of sources associating them with ICAM2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human ICAM2 gene maps to 17q23-25. (PubMed id 1769660)1, 3, 9 Sansom D....Trowsdale J. (1991)
    2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface. (PubMed id 9153399)1, 2 Casasnovas J.M.... Wang J.-H. (1997)
    5. Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1. (PubMed id 2497351)1, 2 Staunton D.E.... Springer T.A. (1989)
    6. Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1. (PubMed id 1676048)1, 9 de Fougerolles A.R....Springer T.A. (1991)
    7. Towards endothelial cell-specific transgene expression in pigs: characterization of the pig ICAM-2 promoter. (PubMed id 17059578)1, 9 Godwin J.W....Cowan P.J. (2006)
    8. Expression of intercellular adhesion molecules ICAM-1 and ICAM-2 in human endometrium: regulation by interferon-gamma. (PubMed id 10050664)1, 9 Thomson A.J....Campbell S. (1999)
    9. Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium. (PubMed id 18842965)1, 9 Porter J.C. and Hall A. (2009)
    10. DC-SIGN binds to HIV-1 glycoprotein 120 in a distinct but overlapping fashion compared with ICAM-2 and ICAM-3. (PubMed id 14970226)1, 9 Su S.V....Lee B. (2004)

    External Searches for ICAM2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing ICAM2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3384 HGNC: 5345 AceView: ICAM2 Ensembl:ENSG00000108622 euGenes: HUgn3384
    ECgene: ICAM2 Kegg: 3384 H-InvDB: ICAM2

    Other Databases showing ICAM2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ICAM2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ICAM2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ICAM2 Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_262

    Intellectual Property
    for ICAM2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ICAM2 gene:
    Search GeneIP for patents involving ICAM2

    GeneCards and IP:
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