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ICAM2 Gene

protein-coding   GIFtS: 65
GCID: GC17M062079

Intercellular Adhesion Molecule 2

  See ICAM2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Intercellular Adhesion Molecule 21 2
ICAM-22 3
CD1022
CD102 Antigen3

External Ids:    HGNC: 53451   Entrez Gene: 33842   Ensembl: ENSG000001086227   OMIM: 1466305   UniProtKB: P135983   
ORGUL members:         

Export aliases for ICAM2 gene to outside databases

Previous GC identifers: GC17M061717 GC17M064506 GC17M062420 GC17M062553 GC17M059433 GC17M057447


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ICAM2 Gene:
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM
proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the
leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking
LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response,
NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune
response and surveillance. Several transcript variants encoding the same protein have been found for this gene.
(provided by RefSeq, Jul 2008)

GeneCards Summary for ICAM2 Gene:
ICAM2 (intercellular adhesion molecule 2) is a protein-coding gene. Diseases associated with ICAM2 include polyarteritis nodosa, and idiopathic pulmonary fibrosis. GO annotations related to this gene include integrin binding. An important paralog of this gene is ICAM4.

UniProtKB/Swiss-Prot: ICAM2_HUMAN, P13598
Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may
play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive
interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte
recirculation, and other cellular interactions important for immune response and surveillance

Gene Wiki entry for ICAM2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ICAM2 gene promoter:
         HOXA9   HOXA9B   Sox5   Meis-1b   AREB6   Meis-1a   MRF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidICAM2 promoter sequence
   Search Chromatin IP Primers for ICAM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ICAM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.3   Ensembl cytogenetic band:  17q23.3   HGNC cytogenetic band: 17q23.3

ICAM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ICAM2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M062079:  view genomic region     (about GC identifiers)

Start:
62,079,954 bp from pter      End:
62,097,994 bp from pter
Size:
18,041 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ICAM2_HUMAN, P13598 (See protein sequence)
Recommended Name: Intercellular adhesion molecule 2 precursor  
Size: 275 amino acids; 30654 Da
1 PDB 3D structure from and Proteopedia for ICAM2:
1ZXQ (3D)    
Secondary accessions: Q14600

Explore the universe of human proteins at neXtProt for ICAM2: NX_P13598

Explore proteomics data for ICAM2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys128
  • Glycosylation2 at Asn47, Asn82, Asn105, Asn153, Asn176, Asn187
  • Modification sites at PhosphoSitePlus

  • See ICAM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_000864.2  NP_001093256.1  NP_001093257.1  NP_001093258.1  NP_001093259.1  

    ENSEMBL proteins: 
     ENSP00000463199   ENSP00000462617   ENSP00000464372   ENSP00000392634   ENSP00000464665  
     ENSP00000462579   ENSP00000464331   ENSP00000463945   ENSP00000463862   ENSP00000415283  
     ENSP00000388666  
    Reactome Protein details: P13598

    ICAM2 Human Recombinant Protein Products:

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    Novus Biologicals ICAM2 Proteins
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    Sino Biological Recombinant Protein for ICAM2
    Sino Biological Cell Lysate for ICAM2
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    Cloud-Clone Corp. Proteins for ICAM2

     
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    ICAM2 Antibody Products:

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    ICAM2 Assay Products:

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    Cloud-Clone Corp. ELISAs for ICAM2
    Cloud-Clone Corp. CLIAs for ICAM2
    eBioscience ELISAs for ICAM2:  
                        Human sICAM-2 Platinum ELISA 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    ENDOLIG: Endogenous ligands
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    5 InterPro protein domains:
     IPR015653 ICAM2
     IPR003988 ICAM
     IPR013768 ICAM_N
     IPR013783 Ig-like_fold
     IPR003987 ICAM_VCAM_N

    Graphical View of Domain Structure for InterPro Entry P13598

    ProtoNet protein and cluster: P13598

    3 Blocks protein domains:
    IPB003987 Intercellular adhesion molecule/vascular cell adhesion molecule-1 signature
    IPB003988 Intercellular adhesion molecule (ICAM) family signature
    IPB013768 Intercellular adhesion molecule


    UniProtKB/Swiss-Prot: ICAM2_HUMAN, P13598
    Similarity: Belongs to the immunoglobulin superfamily. ICAM family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with ICAM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ICAM2_HUMAN, P13598
    Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may
    play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive
    interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte
    recirculation, and other cellular interactions important for immune response and surveillance

         Genatlas biochemistry entry for ICAM2:
    adhesion molecule,intercellular 2,ligand for (LFA1,CD11A/CD18),expressed in resting
    lymphocyte,monocyte,platelet,vascular endothelium,redistributed by ezrin (VIL2) as a target for killer cells,also
    interacting with ICAM1 and VIL2 in microvillar projections,under phosphatidylinositol-4,5 biphosphate
    regulation,Ig superfamily

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding IPI1448173
         
    Find genes that share ontologies with ICAM2           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Icam2):
     hematopoietic system  immune system  respiratory system 

    Find genes that share phenotypes with ICAM2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Icam2tm1Jcgr for ICAM2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ICAM2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ICAM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ICAM2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ICAM2

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    2 qRT-PCR Assays for microRNAs that regulate ICAM2:
    hsa-miR-3934 hsa-miR-3157-5p
    SwitchGear 3'UTR luciferase reporter plasmidICAM2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ICAM2

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    GenScript: all cDNA clones in your preferred vector (see all 5): ICAM2 (NM_000873)
    Sino Biological Human cDNA Clone for ICAM2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ICAM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICAM2
    Addgene plasmids for ICAM2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ICAM2_HUMAN, P13598: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton2
    extracellular2
    lysosome1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001931uropod IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0016020membrane ----
    GO:0071944cell periphery ----

    Find genes that share ontologies with ICAM2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ICAM2 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    2Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    3Degradation of the extracellular matrix
    Extracellular matrix organization0.34
    4Immune response Role of DAP12 receptors in NK cells
    Natural killer cell mediated cytotoxicity0.31
    5Integrin cell surface interactions
    Integrin cell surface interactions


    Find genes that share SuperPaths with ICAM2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ICAM2
        Transendothelial Migration of Leukocytes

    1 GeneGo (Thomson Reuters) Pathway for ICAM2
        Immune response Role of integrins in NK cells cytotoxicity

    1 BioSystems Pathway for ICAM2
        amb2 Integrin signaling


    2 Reactome Pathways for ICAM2
        Integrin cell surface interactions
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    2 Kegg Pathways  (Kegg details for ICAM2):
        Cell adhesion molecules (CAMs)
    Natural killer cell mediated cytotoxicity

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ICAM2: 
              Cell Surface Markers in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ICAM2

    Selected Interacting proteins for ICAM2 (P135983) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RDXP352413I2D: score=5 
    EZRP153113I2D: score=4 
    MSNP260383I2D: score=3 
    ITGB2P051073I2D: score=2 
    CD209Q9NNX63I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016337cell-cell adhesion IEA--
    GO:0030198extracellular matrix organization TAS--
    GO:0050776regulation of immune response TAS--

    Find genes that share ontologies with ICAM2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ICAM2

    7 Novoseek inferred chemical compound relationships for ICAM2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 7.24 1 11869363 (1)
    calcium 0 1 10688433 (1)
    tyrosine 0 3 11472628 (1), 11463761 (1), 11825565 (1)
    glutamate 0 1 9700512 (1)
    polysaccharide 0 3 18155766 (2), 15545280 (1)
    5fluorouracil 0 1 10362102 (1)
    serine 0 1 16857989 (1)



    Find genes that share compounds with ICAM2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ICAM2 gene (5 alternative transcripts): 
    NM_000873.3  NM_001099786.1  NM_001099787.1  NM_001099788.1  NM_001099789.1  

    Unigene Cluster for ICAM2:

    Intercellular adhesion molecule 2
    Hs.431460  [show with all ESTs]
    Unigene Representative Sequence: BQ214437
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000578379 ENST00000583684 ENST00000578892 ENST00000449662(uc002jdu.4)
    ENST00000579788 ENST00000581417 ENST00000579687 ENST00000578313 ENST00000583366
    ENST00000584084 ENST00000584403 ENST00000580011(uc010wpx.1) ENST00000580389
    ENST00000583186 ENST00000412356(uc002jdw.4 uc010ded.3) ENST00000418105(uc002jdx.4 uc002jdv.4)

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    2 qRT-PCR Assays for microRNAs that regulate ICAM2:
    hsa-miR-3934 hsa-miR-3157-5p
    SwitchGear 3'UTR luciferase reporter plasmidICAM2 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat ICAM2

    Additional mRNA sequence: 

    AB209878.1 AF340052.1 AF340053.1 AK223219.1 AK293110.1 AK295382.1 AK309953.1 BC003097.1 
    CR541812.1 CR541834.1 X15606.1 

    11 DOTS entries:

    DT.455933  DT.91995331  DT.101984915  DT.100795618  DT.101984913  DT.95280474  DT.92425823  DT.92425828 
    DT.97775460  DT.95249996  DT.97846486 

    Selected AceView cDNA sequences (see all 218):

    BF794588 CR615927 CB530017 AA341271 AI167668 AI090516 CR599573 CR621141 
    BQ001423 AI141055 BM695682 BX355347 CD014035 T27750 BX444203 BM852307 
    BQ709781 BU181068 BE269543 AI078058 BQ573749 BQ017163 BI837883 BM924501 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ICAM2    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5
    SP1:                                                      
    SP2:        -     -                 -                     
    SP3:        -     -     -           -                     
    SP4:                                -                     


    ECgene alternative splicing isoforms for ICAM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ICAM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCACCACCA
    ICAM2 Expression
    About this image


    ICAM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Peripheral blood-derived hematopoietic stem cells (family)
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Heart Tube
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Human umbilical vein endothelial cells (HUVEC)
             Endothelial-like cells
     
     Dermis (Integumentary System)
             Dermal Fibroblasts Dorsal Dermis
     
     Bone (Muscoskeletal System)
             Zeugopod Periosteum
    ICAM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ICAM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.431460
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ICAM2: 
              Cell Surface Markers in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Tight Junctions in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for ICAM2
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    QuantiFast Probe-based Assays in human, mouse, rat ICAM2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ICAM2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Icam21 , 5 intercellular adhesion molecule 21, 5 71.71(n)1
    60.89(a)1
      11 (69.09 cM)5
    158961  NM_010494.11  NP_034624.11 
     1063776565 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    11(a)
    10(a)
    many ↔ many
    many ↔ many
    GL344305.1(30522-49910)
    GL343233.1(1353200-1357090)


    ENSEMBL Gene Tree for ICAM2 (if available)
    TreeFam Gene Tree for ICAM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ICAM2 gene
    ICAM42  ICAM52  ICAM12  ICAM32  
    3 SIMAP similar genes for ICAM2 using alignment to 10 protein entries:     ICAM2_HUMAN (see all proteins):
    ICAM-1    ICAM3    P3.58

    Find genes that share paralogs with ICAM2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ICAM2
    PGOHUM00000262989


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ICAM2 (see all 371)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1153811781,2
    C,F--62082159(+) GCATGG/AGACAT 5 -- int11Minor allele frequency- A:0.04WA 118
    rs1458041881,2
    --62082220(+) TAAATA/GTTGGT 5 -- int10--------
    rs1882735061,2
    --62082369(+) CGATGA/TCAGTG 5 -- int10--------
    rs1388438581,2
    F--62082507(+) TTCCCG/AGAGCA 10 /S syn11Minor allele frequency- A:0.00NA 4550
    rs1504823351,2
    C--62082677(+) TTGGG-/CCTCAA 10 P AQ fra10--------
    rs55031,2,,4
    C,F,O,H--62082686(-) AGCTGA/GCGGTT 10 T A mis111Minor allele frequency- T:0.00MN NS EA NA WA 5476
    rs2004489601,2
    C--62082751(+) AAACAC/ATGGGC 5 -- int11Minor allele frequency- A:0.00EU 1323
    rs1812772751,2
    C--62082755(+) ACTGGA/GCAGTC 5 -- int10--------
    rs98908391,2
    C,F,H--62082848(+) GGTCAT/CTGGGG 5 -- int15Minor allele frequency- C:0.01NS EA WA 538
    rs1386167741,2
    --62082871(+) CTTTCA/CCCTTG 5 -- int10--------

    HapMap Linkage Disequilibrium report for ICAM2 (62079954 - 62097994 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ICAM2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908684CNV Loss21882294
    nsv908685CNV Loss21882294
    nsv833511CNV Loss17160897
    nsv517272CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ICAM2
    DNA2.0 Custom Variant and Variant Library Synthesis for ICAM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 146630    OMIM disorders: --

    2 diseases for ICAM2:    
    About MalaCards
    polyarteritis nodosa    idiopathic pulmonary fibrosis


    Find genes that share disorders with ICAM2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ICAM2 gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 29.8 5 10223354 (2), 8083366 (1), 17701178 (1), 9863370 (1)
    necrosis 23.1 2 11719371 (1), 10574717 (1)
    immunodeficiency 22.5 4 12477827 (1), 14970226 (1), 12122001 (1), 19211748 (1)
    rheumatoid arthritis 14.5 1 8394794 (1)
    tumors 14.4 8 18978946 (3), 1348028 (2), 8604238 (1), 8922057 (1) (see all 5)
    colitis ulcerative 10.5 2 9473377 (1), 10931137 (1)
    lymphoma 7.39 1 8648141 (1)
    senile plaques 3.53 1 7904796 (1)
    cancer 3.19 2 14999228 (1), 15269165 (1)
    colon carcinoma 0.496 2 11169447 (1)

    Genetic Association Database (GAD): ICAM2
    Human Genome Epidemiology (HuGE) Navigator: ICAM2 (5 documents)

    Export disorders for ICAM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ICAM2 gene, integrated from 10 sources (see all 231):
    (articles sorted by number of sources associating them with ICAM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human ICAM2 gene maps to 17q23-25. (PubMed id 1769660)1, 3, 9 Sansom D....Trowsdale J. (Genomics 1991)
    2. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    3. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface. (PubMed id 9153399)1, 2 Casasnovas J.M.... Wang J.-H. (Nature 1997)
    7. Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1. (PubMed id 2497351)1, 2 Staunton D.E.... Springer T.A. (Nature 1989)
    8. Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1. (PubMed id 1676048)1, 9 de Fougerolles A.R....Springer T.A. (J. Exp. Med. 1991)
    9. Towards endothelial cell-specific transgene expression in pigs: characterization of the pig ICAM-2 promoter. (PubMed id 17059578)1, 9 Godwin J.W....Cowan P.J. (Xenotransplantation 2006)
    10. Expression of intercellular adhesion molecules ICAM-1 and ICAM-2 in human endometrium: regulation by interferon-gamma. (PubMed id 10050664)1, 9 Thomson A.J....Campbell S. (Mol. Hum. Reprod. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3384 HGNC: 5345 AceView: ICAM2 Ensembl:ENSG00000108622 euGenes: HUgn3384
    ECgene: ICAM2 Kegg: 3384 H-InvDB: ICAM2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ICAM2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ICAM2 Genetics and Cytogenetics in Oncology and Haematology
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_262

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ICAM2 gene:
    Search GeneIP for patents involving ICAM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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