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ICAM1 Gene

protein-coding   GIFtS: 75
GCID: GC19P010381

Intercellular Adhesion Molecule 1

  See ICAM1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Intercellular Adhesion Molecule 11 2     CD542
Major Group Rhinovirus Receptor2 3     P3.582
ICAM-12 3     Cell Surface Glycoprotein P3.582
Human Rhinovirus Receptor1     Intercellular Adhesion Molecule 1 (CD54), Human Rhinovirus Receptor2
BB22     CD54 Antigen3

External Ids:    HGNC: 53441   Entrez Gene: 33832   Ensembl: ENSG000000903397   OMIM: 1478405   UniProtKB: P053623   

Export aliases for ICAM1 gene to outside databases

Previous GC identifers: GC19P010503 GC19P010604 GC19P010226 GC19P010243 GC19P010244 GC19P010247 GC19P009965


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ICAM1 Gene:
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the
immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as
a receptor. (provided by RefSeq, Jul 2008)

GeneCards Summary for ICAM1 Gene:
ICAM1 (intercellular adhesion molecule 1) is a protein-coding gene. Diseases associated with ICAM1 include lupus erythematosus tumidus, and folliculotropic mycosis fungoides. GO annotations related to this gene include integrin binding and receptor activity. An important paralog of this gene is ICAM4.

UniProtKB/Swiss-Prot: ICAM1_HUMAN, P05362
Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During
leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through
ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus

Gene Wiki entry for ICAM1 (ICAM-1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the ICAM1 gene promoter:
         CREB   AP-2alpha isoform 3   deltaCREB   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidICAM1 promoter sequence
   Search Chromatin IP Primers for ICAM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ICAM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3-p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.3-p13.2

ICAM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ICAM1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P010381:  view genomic region     (about GC identifiers)

Start:
10,381,511 bp from pter      End:
10,397,291 bp from pter
Size:
15,781 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ICAM1_HUMAN, P05362 (See protein sequence)
Recommended Name: Intercellular adhesion molecule 1 precursor  
Size: 532 amino acids; 57825 Da
Subunit: Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and
promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Binds to coxsackievirus A21 capsid
proteins and acts as a receptor for this virus
Selected PDB 3D structures from and Proteopedia for ICAM1 (see all 11):
1D3E (3D)        1D3I (3D)        1D3L (3D)        1IAM (3D)        1IC1 (3D)        1IJ4 (3D)    
Secondary accessions: B2R6M3 Q5NKV7 Q96B50

Explore the universe of human proteins at neXtProt for ICAM1: NX_P05362

Explore proteomics data for ICAM1 at MOPED

Post-translational modifications: 

  • Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis1
  • Glycosylation2 at Ile60, Asn130, Asn145, Asn183, Asn202, Asn267, Asn296, Asn385, Asn406
  • Modification sites at PhosphoSitePlus

  • See ICAM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000192.2  
    ENSEMBL proteins: 
     ENSP00000264832   ENSP00000413124   ENSP00000465680  
    Reactome Protein details: P05362

    ICAM1 Human Recombinant Protein Products:

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    R&D Systems Recombinant & Natural Proteins for ICAM1 (ICAM-1/CD54)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ICAM1
    OriGene Protein Over-expression Lysate for ICAM1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ICAM1
    GenScript Custom Purified and Recombinant Proteins Services for ICAM1
    Novus Biologicals ICAM1 Proteins
    Novus Biologicals ICAM1 Lysate
    Sino Biological Recombinant Protein for ICAM1
    Sino Biological Cell Lysate for ICAM1
    ProSpec Recombinant Protein for ICAM1
    Cloud-Clone Corp. Proteins for ICAM1

     
    eBioscience Proteins for ICAM1:  
                        Recombinant Human ICAM-1 50 ug

    ICAM1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ICAM1
    R&D Systems Antibodies for ICAM1 (ICAM-1/CD54)
    Cell Signaling Technology (CST) Antibodies for ICAM1 
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    Novus Biologicals ICAM1 Antibodies
    Abcam antibodies for ICAM1
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    ThermoFisher Antibody for ICAM1
    LSBio Antibodies in human, mouse, rat for ICAM1

    ICAM1 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of ICAM1
    OriGene Custom Assay Services for ICAM1
    R&D Systems ELISAs for ICAM1 (ICAM-1/CD54)         (see all)
    GenScript Custom Assay Services for ICAM1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ICAM1
    Cloud-Clone Corp. CLIAs for ICAM1
    eBioscience ELISAs for ICAM1: (see all 6
                        Human sICAM-1 Platinum ELISA 96 tests


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    ENDOLIG: Endogenous ligands
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    5 InterPro protein domains:
     IPR003988 ICAM
     IPR013768 ICAM_N
     IPR013783 Ig-like_fold
     IPR003599 Ig_sub
     IPR003987 ICAM_VCAM_N

    Graphical View of Domain Structure for InterPro Entry P05362

    ProtoNet protein and cluster: P05362

    4 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB003987 Intercellular adhesion molecule/vascular cell adhesion molecule-1 signature
    IPB003988 Intercellular adhesion molecule (ICAM) family signature
    IPB013768 Intercellular adhesion molecule


    UniProtKB/Swiss-Prot: ICAM1_HUMAN, P05362
    Similarity: Belongs to the immunoglobulin superfamily. ICAM family
    Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with ICAM1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ICAM1_HUMAN, P05362
    Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During
    leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through
    ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus

         Genatlas biochemistry entry for ICAM1:
    adhesion molecule,intercellular 1,ligand for LFA1 (CD11A/CD18),expressed on vascular endothelium and
    leukocytes,up-regulated by cytokines,inhibiting interleukin 4 production by naive T cells,also interacting with
    ezrin VIL2 and ICAM2 in microvillar projections under phosphatidylinositol-4,5 biphosphate regulation,human
    rhinovirus receptor with some allele(s) predisposing to cerebral malaria,also contributing to multiple sclerosis
    susceptibility

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618virus receptor activity IEA--
    GO:0004872receptor activity TAS2538243
    GO:0004888transmembrane signaling receptor activity TAS2538243
    GO:0005178integrin binding IPI1448173
    GO:0005515protein binding IPI12716892
         
    Find genes that share ontologies with ICAM1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ICAM1:
     Decreased cilium length after  

         14 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Icam1):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  mortality/aging 
     muscle  nervous system  tumorigenesis  vision/eye 

    Find genes that share phenotypes with ICAM1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ICAM1: Icam1tm1Bay Icam1tm1Jcgr Icam1tm1Cws Icam1tm1Alb

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ICAM1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ICAM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ICAM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ICAM1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ICAM1:
    hsa-mir-221-3p (MIRT004430), hsa-mir-98-5p (MIRT027615), hsa-mir-1256 (MIRT005710), hsa-mir-17-5p (MIRT005708), hsa-mir-17-3p (MIRT004020), hsa-mir-155-5p (MIRT005709), hsa-mir-335-5p (MIRT018131), hsa-mir-31-5p (MIRT005707), hsa-mir-21-5p (MIRT005952), hsa-mir-222-3p (MIRT004595)

    Block miRNA regulation of human, mouse, rat ICAM1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate ICAM1:
    hsa-miR-129-5p hsa-miR-3121-3p hsa-miR-1286 hsa-miR-3945
    SwitchGear 3'UTR luciferase reporter plasmidICAM1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ICAM1
    Predesigned siRNA for gene silencing in human, mouse, rat ICAM1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ICAM1

    Clone
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    OriGene clones in human, mouse for ICAM1 (see all 7)
    OriGene ORF clones in mouse, rat for ICAM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ICAM1 (NM_000201)
    Sino Biological Human cDNA Clone for ICAM1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ICAM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICAM1
    Addgene plasmids for ICAM1 

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM1

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12360) for ICAM1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ICAM1_HUMAN, P05362: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    plasma membrane4
    cytoskeleton3
    nucleus3
    cytosol1
    endoplasmic reticulum1
    endosome1
    lysosome1
    mitochondrion1
    peroxisome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001772immunological synapse IEA--
    GO:0005615extracellular space IDA9290466
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS2538243
    GO:0009897external side of plasma membrane IEA--

    Find genes that share ontologies with ICAM1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ICAM1 About   (see all 36)  
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.59
    2Development VEGF signaling and activation
    Development VEGF signaling and activation0.75
    3Cytokine production by Th17 cells in CF
    Cytokine production by Th17 cells in CF0.72
    4Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    5Immune response IFN gamma signaling pathway
    Immune response IFN gamma signaling pathway0.43


    Find genes that share SuperPaths with ICAM1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ICAM1
        LDL Oxidation in Atherogenesis
    Transendothelial Migration of Leukocytes

    1 Cell Signaling Technology (CST) Pathway for ICAM1
        Adhesion

    Selected GeneGo (Thomson Reuters) Pathways for ICAM1 (see all 6)
        Immune response MIF-mediated glucocorticoid regulation
    Inhibitory action of Lipoxins on neutrophil migration
    Immune response IFN gamma signaling pathway
    Development VEGF signaling and activation
    Immune response Role of integrins in NK cells cytotoxicity

    Selected BioSystems Pathways for ICAM1 (see all 9)
        Type II interferon signaling (IFNG)
    Spinal Cord Injury
    IL-5 Signaling Pathway
    Selenium Pathway
    Interleukin-11 Signaling Pathway


    3 Reactome Pathways for ICAM1
        Integrin cell surface interactions
    Interferon gamma signaling
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    Selected Kegg Pathways  (Kegg details for ICAM1) (see all 13):
        NF-kappa B signaling pathway
    Cell adhesion molecules (CAMs)
    Natural killer cell mediated cytotoxicity
    TNF signaling pathway
    Leukocyte transendothelial migration

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ICAM1 (see all 20): 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Tight Junctions in human mouse rat
              Multiple Sclerosis in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Th17 Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ICAM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ICAM1 (P053622, 3 ENSP000002648324) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG482, 3, ENSP000003448184MINT-4053108 I2D: score=1 STRING: ENSP00000344818
    ITGAMP112153, ENSP000002874974I2D: score=3 STRING: ENSP00000287497
    ITGB2P051073, ENSP000003032424I2D: score=3 STRING: ENSP00000303242
    FGGP026793, ENSP000003368294I2D: score=1 STRING: ENSP00000336829
    ITGALP207013, ENSP000003492524I2D: score=5 STRING: ENSP00000349252
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 49):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001541ovarian follicle development IEA--
    GO:0001666response to hypoxia ----
    GO:0001910regulation of leukocyte mediated cytotoxicity TAS16038038
    GO:0001975response to amphetamine IEA--
    GO:0002291T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP2477710

    Find genes that share ontologies with ICAM1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ICAM1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ThiolutinBacterial RNA polymerase inhibitor[87-11-6]
    Heparin sodium saltAnticoagulant[9041-08-1]
    Echistatin, alpha1 isoform alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor[154303-05-6]
    RGDS peptideIntegrin binding sequence; inhibits integrin receptor function[91037-65-9]
    Ac2-26Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation[151988-33-9]

    1 HMDB Compound for ICAM1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Simvastatin(+)-Simvastatin (see all 28)79902-63-9--

    2 DrugBank Compounds for ICAM1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NatalizumabAnti-alpha4 integrin (see all 2)189261-10-7target--11752352
    HyaluronanHyaluronate (see all 4)9067-32-7target----

    Selected Novoseek inferred chemical compound relationships for ICAM1 gene (see all 132)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rantes 64.9 105 20350425 (5), 12506144 (4), 12558634 (4), 19834460 (3) (see all 64)
    pdtc 58.2 37 7532665 (5), 8871659 (5), 10549609 (3), 10594564 (2) (see all 18)
    slex 56.8 30 9430509 (3), 14507735 (2), 15187162 (2), 8547121 (1) (see all 20)
    enlimomab 54.1 3 10096530 (1), 11673584 (1), 9973515 (1)
    sele 53.7 7 17367508 (2), 18248671 (1), 20101252 (1), 7525451 (1) (see all 6)
    lfa703 52.7 3 15618295 (2), 17482516 (1)
    fibrinogen 52.2 229 10712387 (7), 15189898 (6), 10903502 (6), 8995280 (5) (see all 90)
    groalpha 50.5 7 16687566 (3), 11163401 (1), 11566005 (1), 16858424 (1) (see all 5)
    alicaforsen 49.8 6 18774928 (1), 16197343 (1), 11890355 (1)
    fmlp 45 19 15550998 (2), 12234777 (2), 12610322 (2), 14723618 (2) (see all 10)



    Find genes that share compounds with ICAM1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ICAM1 gene: 
    NM_000201.2  

    Unigene Cluster for ICAM1:

    Intercellular adhesion molecule 1
    Hs.643447  [show with all ESTs]
    Unigene Representative Sequence: NM_000201
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264832(uc002mnq.2 uc010xle.1) ENST00000423829 ENST00000588645
    ENST00000585443 ENST00000592686
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate ICAM1:
    hsa-miR-129-5p hsa-miR-3121-3p hsa-miR-1286 hsa-miR-3945
    SwitchGear 3'UTR luciferase reporter plasmidICAM1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ICAM1
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ICAM1 (NM_000201)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ICAM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICAM1
    Addgene plasmids for ICAM1 
    Primer
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    OriGene qPCR primer pairs and template standards for ICAM1
    OriGene qSTAR qPCR primer pairs in human, mouse for ICAM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ICAM1
      QuantiTect SYBR Green Assays in human, mouse, rat ICAM1
      QuantiFast Probe-based Assays in human, mouse, rat ICAM1
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12360) for ICAM1 

    Additional mRNA sequence: 

    AF340038.1 AF340039.1 AK130659.1 AK298054.1 AK298983.1 AK301412.1 AK312636.1 BC015969.2 
    BT006854.1 J03132.1 M24283.1 M55038.1 S82847.1 X06990.1 

    15 DOTS entries:

    DT.95145860  DT.87016703  DT.100821617  DT.92444106  DT.121464281  DT.95157958  DT.121464277  DT.95229577 
    DT.121464141  DT.121464225  DT.121464232  DT.121464260  DT.92444125  DT.95282573  DT.100821620 

    Selected AceView cDNA sequences (see all 282):

    AU104806 BU192598 CA309669 BI823891 BI772468 AU099232 BQ678437 BG945719 
    BQ676745 AU133414 AI753618 CB138808 BI768722 AI753027 BM854375 NM_022377 
    CK429562 BC000046 CB265238 T28374 BP346334 BQ710223 BC015969 CB529024 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ICAM1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c
    SP1:                                      -     -                                                                           
    SP2:                          -           -     -                                                                           
    SP3:                                -     -     -     -     -     -     -     -     -                                       
    SP4:                                      -     -     -                                                                     
    SP5:                                                                                                  -                     


    ECgene alternative splicing isoforms for ICAM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ICAM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCACTGCA
    ICAM1 Expression
    About this image


    ICAM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 7 entries
             Chorionic Mesenchymal Stromal Cells Chorionic Villus
             Placenta-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Chorionic Mesenchymal Stromal Cells Chorionic Villus
             Placenta-derived mesenchymal stem cells
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Granulocyte-Monocyte Progenitor Cells Hematopoietic Bone Marrow
             Activated peripheral blood derived-mononuclear cells (PROVENGEŽ)
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Sinusoidal Endothelial Cells Sinusoids
     
     Chorion (Extraembryonic Tissues)
             Chorionic Mesenchymal Stromal Cells Chorionic Villus
    ICAM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ICAM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.643447
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ICAM1 (see all 20): 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Tight Junctions in human mouse rat
              Multiple Sclerosis in human mouse rat
              T-cell & B-cell Activation in human mouse rat
              Th17 Response in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICAM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for ICAM1 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Icam11 , 5 intercellular adhesion molecule 11, 5 64.77(n)1
    54.81(a)1
      9 (7.69 cM)5
    158941  NM_010493.21  NP_034623.11 
     210159605 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    29(a)
    23(a)
    many ↔ many
    many ↔ many
    GL344305.1(30522-49910)
    GL343233.1(1353200-1357090)


    ENSEMBL Gene Tree for ICAM1 (if available)
    TreeFam Gene Tree for ICAM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ICAM1 gene
    ICAM42  ICAM52  ICAM22  ICAM32  
    5 SIMAP similar genes for ICAM1 using alignment to 5 protein entries:     ICAM1_HUMAN (see all proteins):
    sICAM-1    ICAM-1    P3.58    ICAM5    ICAM3

    Find genes that share paralogs with ICAM1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ICAM1
    PGOHUM00000237476


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    ICAM1_HUMAN, P05362: Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria
    [MIM:611162]


    Selected SNPs for ICAM1 (see all 540)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs54911,2,,4
    C,F,O,Hother110321953(+) GCCCAA/TGTTGT 2 K M mis1 ese334Minor allele frequency- T:0.08MN NS EA NA CSA WA EU 8701
    rs1823285261,2
    --10316104(+) CAGAAC/TGAGAC 1 -- us2k10--------
    rs1880683271,2
    --10316129(+) AAACAA/GACAAA 1 -- us2k10--------
    rs1407103601,2
    C--10316154(+) CTCAGA/GTGACA 1 -- us2k10--------
    rs1500999551,2
    --10316305(+) TCACCC/TAGGCT 1 -- us2k10--------
    rs50303861,2
    C,F--10316508(+) ATCCTC/GCCATC 1 -- us2k12Minor allele frequency- G:0.02NS 94
    rs50303391,2
    C,F,H--10316548(+) TGGGAG/ACCGCG 1 -- us2k18Minor allele frequency- A:0.00NS EA NA 494
    rs1418827201,2
    --10316568(+) ATTTTC/TGTCTG 1 -- us2k10--------
    rs50303871,2
    C--10316693(+) GGGACT/GTGGGC 1 -- us2k14Minor allele frequency- G:0.01NS NA 98
    rs1454236571,2
    --10316770(+) CCGTGA/GCGCAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ICAM1 (10381511 - 10397291 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ICAM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911030CNV Loss21882294
    nsv911029CNV Loss21882294
    dgv3726n71CNV Loss21882294
    dgv3725n71CNV Loss21882294
    nsv911033CNV Gain21882294
    nsv911034CNV Gain21882294

    Human Gene Mutation Database (HGMD): ICAM1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ICAM1
    DNA2.0 Custom Variant and Variant Library Synthesis for ICAM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147840   
    OMIM disorders: 611162  
    Selected diseases for ICAM1 (see all 43):    
    About MalaCards
    lupus erythematosus tumidus    folliculotropic mycosis fungoides    dissecting cellulitis of the scalp    lethal midline granuloma
    lichen planus    cellulitis    vasculitis    cerebral malaria
    erythema multiforme    rheumatoid vasculitis    leukostasis    adult dermatomyositis
    arteriosclerosis obliterans    alopecia areata    dengue disease    common cold
    rapidly progressive glomerulonephritis    lymphocytic vasculitis    alcoholic hepatitis    arteriosclerosis

    Selected diseases from the University of Copenhagen DISEASES database for ICAM1 (see all 29):
    Atherosclerosis     Asthma     Hypersensitivity reaction type II disease     Diabetes mellitus
    Heart disease     Malaria     Kidney disease     Leukostasis
    Dermatitis     Arthritis     Hypertension     Vasculitis
    Cerebrovascular accident     Inflammatory bowel disease     Psoriasis     Diabetic retinopathy
    Melanoma     Connective tissue disease     Allergic rhinitis     Lymphoma

    Find genes that share disorders with ICAM1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ICAM1 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 82.7 484 15037117 (4), 7912141 (3), 7512004 (3), 7524087 (3) (see all 99)
    necrosis 81.6 718 8104967 (3), 17452936 (3), 15764154 (3), 1974275 (2) (see all 99)
    atherosclerosis 70.2 108 18420209 (4), 9416885 (3), 12425201 (2), 9187938 (2) (see all 78)
    tumors 68.8 1040 8605704 (7), 10738180 (6), 10090402 (5), 12149643 (5) (see all 99)
    malaria cerebral 60.2 16 7650476 (2), 9259284 (2), 9502610 (1), 9861406 (1) (see all 13)
    psoriasis 53 37 7902785 (4), 8867647 (2), 7521104 (2), 9749989 (1) (see all 27)
    melanoma 50.2 323 1347555 (7), 9241963 (7), 7915992 (6), 1284075 (6) (see all 99)
    rheumatoid arthritis 49.5 48 7911453 (2), 8856611 (2), 18475445 (2), 7897232 (2) (see all 34)
    asthma 47.9 135 11144049 (4), 9111502 (3), 7802929 (3), 1967851 (3) (see all 76)
    atherosclerotic plaque 47.8 27 16430720 (4), 8095156 (2), 20075743 (2), 8640995 (2) (see all 19)

    Genetic Association Database (GAD): ICAM1
    Human Genome Epidemiology (HuGE) Navigator: ICAM1 (209 documents)

    Export disorders for ICAM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ICAM1 gene, integrated from 10 sources (see all 4334):
    (articles sorted by number of sources associating them with ICAM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The K469E polymorphism of the intercellular adhesion molecule-1 gene is associated with plasma fibrinogen level in type 2 diabetes. (PubMed id 15736117)1, 4, 9 Yokoyama H....Nishizawa Y. (Metab. Clin. Exp. 2005)
    2. ICAM-1 (Lys469Glu) and PECAM-1 (Leu125Val) polymorphisms in diffuse astrocytomas. (PubMed id 19306055)1, 4, 9 Burim R.V....Carlotti-JA_nior C.G. (Clin. Exp. Med. 2009)
    3. ICAM1 and VCAM1 polymorphisms, coronary artery calcium, and circulating levels of soluble ICAM-1: the multi-ethnic study of atherosclerosis (MESA). (PubMed id 18420209)1, 4, 9 Bielinski S.J....Arnett D. (Atherosclerosis 2008)
    4. Polymorphism in L-selectin, E-selectin and ICAM-1 genes in Asian Indian pediatric patients with celiac disease. (PubMed id 16916660)1, 4, 9 Kaur G....Mehra N.K. (Hum. Immunol. 2006)
    5. Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels. (PubMed id 20167578)1, 4, 9 Barbalic M....Benjamin E.J. (Hum. Mol. Genet. 2010)
    6. Variations in host genes encoding adhesion molecules and susceptibility to falciparum malaria in India. (PubMed id 19055786)1, 4, 9 Sinha S....Habib S. (Malar. J. 2008)
    7. Carrier-state of two or three polymorphic variants of MTHFR, IL-6 and ICAM1 genes increases the risk of coronary artery disease. (PubMed id 19169973)1, 4, 9 Sarecka-Hujar B....Krauze J. (Kardiol Pol 2008)
    8. Intercellular adhesion molecule-1 gene polymorphism in Iranian patients with multiple sclerosis. (PubMed id 17868277)1, 4, 9 Mousavi S.A....Ghaderi A. (Eur. J. Neurol. 2007)
    9. NOD2/CARD15, NOD1/CARD4, and ICAM-1 gene polymorphisms in Turkish patients with inflammatory bowel disease. (PubMed id 16741608)1, 4, 9 Ozen S.C....Bozdayi A.M. (J. Gastroenterol. 2006)
    10. High risk of cutaneous melanoma amongst carriers of the intercellular adhesion molecule-1 R241 allele. (PubMed id 16432463)1, 4, 9 Vinceti M....Seidenari S. (Melanoma Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3383 HGNC: 5344 AceView: ICAM1andICAM4 Ensembl:ENSG00000090339 euGenes: HUgn3383
    ECgene: ICAM1 Kegg: 3383 H-InvDB: ICAM1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ICAM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ICAM1 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Intercellular_adhesion_molecule
    SeattleSNPshttp://pga.gs.washington.edu/data/icam1/
    Virus Particle ExploreR dbhttp://viperdb.scripps.edu/info_page.php?VDB=1z7z
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Itlect_261

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ICAM1 gene:
    Search GeneIP for patents involving ICAM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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