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Aliases for ICAM1 Gene

Aliases for ICAM1 Gene

  • Intercellular Adhesion Molecule 1 2 3
  • Major Group Rhinovirus Receptor 3 4
  • ICAM-1 3 4
  • Intercellular Adhesion Molecule 1 (CD54), Human Rhinovirus Receptor 3
  • Cell Surface Glycoprotein P3.58 3
  • Human Rhinovirus Receptor 2
  • CD54 Antigen 4
  • P3.58 3
  • CD54 3
  • BB2 3

External Ids for ICAM1 Gene

Previous GeneCards Identifiers for ICAM1 Gene

  • GC19P010503
  • GC19P010604
  • GC19P010226
  • GC19P010243
  • GC19P010244
  • GC19P010247
  • GC19P010381
  • GC19P009965

Summaries for ICAM1 Gene

Entrez Gene Summary for ICAM1 Gene

  • This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for ICAM1 Gene

ICAM1 (Intercellular Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with ICAM1 include malaria and lethal midline granuloma. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include receptor activity and protein complex binding. An important paralog of this gene is ICAM2.

UniProtKB/Swiss-Prot for ICAM1 Gene

  • ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.

  • (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins (PubMed:1968231, PubMed:2538243). Acts as a receptor for Coxsackievirus A21 capsid proteins (PubMed:11160747, PubMed:16004874, PubMed:9539703). Upon Kaposis sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell (PubMed:11413168).

Tocris Summary for ICAM1 Gene

  • Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to another cell or to the extracellular matrix. They have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture.

Gene Wiki entry for ICAM1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICAM1 Gene

Genomics for ICAM1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ICAM1 Gene

Chromosome:
19
Start:
10,270,835 bp from pter
End:
10,286,615 bp from pter
Size:
15,781 bases
Orientation:
Plus strand

Genomic View for ICAM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ICAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICAM1 Gene

Proteins for ICAM1 Gene

  • Protein details for ICAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05362-ICAM1_HUMAN
    Recommended name:
    Intercellular adhesion molecule 1
    Protein Accession:
    P05362
    Secondary Accessions:
    • B2R6M3
    • Q5NKV7
    • Q96B50

    Protein attributes for ICAM1 Gene

    Size:
    532 amino acids
    Molecular mass:
    57825 Da
    Quaternary structure:
    • Homodimer (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. (Microbial infection) Interacts with major receptor group rhinovirus A-B capsid proteins (PubMed:1968231, PubMed:2538243). (Microbial infection) Interacts with Coxsackievirus A21 capsid proteins (PubMed:11160747, PubMed:16004874, PubMed:9539703).

    Three dimensional structures from OCA and Proteopedia for ICAM1 Gene

neXtProt entry for ICAM1 Gene

Proteomics data for ICAM1 Gene at MOPED

Post-translational modifications for ICAM1 Gene

  • Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis
  • Glycosylation at Thr 62, Asn 130, Asn 145, Asn 183, Asn 202, Asn 267, Asn 296, Asn 385, and Asn 406
  • Modification sites at PhosphoSitePlus

Other Protein References for ICAM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ICAM1 (ICAM1)

No data available for DME Specific Peptides for ICAM1 Gene

Domains & Families for ICAM1 Gene

Graphical View of Domain Structure for InterPro Entry

P05362

UniProtKB/Swiss-Prot:

ICAM1_HUMAN :
  • Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. ICAM family.
Domain:
  • Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. ICAM family.
genes like me logo Genes that share domains with ICAM1: view

Function for ICAM1 Gene

Molecular function for ICAM1 Gene

GENATLAS Biochemistry:
adhesion molecule,intercellular 1,ligand for LFA1 (CD11A/CD18),expressed on vascular endothelium and leukocytes,up-regulated by cytokines,inhibiting interleukin 4 production by naive T cells,also interacting with ezrin VIL2 and ICAM2 in microvillar projections under phosphatidylinositol-4,5 biphosphate regulation,human rhinovirus receptor with some allele(s) predisposing to cerebral malaria,also contributing to multiple sclerosis susceptibility
UniProtKB/Swiss-Prot Function:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins (PubMed:1968231, PubMed:2538243). Acts as a receptor for Coxsackievirus A21 capsid proteins (PubMed:11160747, PubMed:16004874, PubMed:9539703). Upon Kaposis sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell (PubMed:11413168).

Gene Ontology (GO) - Molecular Function for ICAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0004872 receptor activity TAS 2538243
GO:0004888 transmembrane signaling receptor activity TAS 2538243
GO:0005178 integrin binding IPI 1448173
GO:0005515 protein binding IPI 7822297
genes like me logo Genes that share ontologies with ICAM1: view
genes like me logo Genes that share phenotypes with ICAM1: view

Animal Models for ICAM1 Gene

MGI Knock Outs for ICAM1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ICAM1

Clone Products

  • Addgene plasmids for ICAM1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ICAM1 Gene

Localization for ICAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICAM1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ICAM1 Gene COMPARTMENTS Subcellular localization image for ICAM1 gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 3
cytoskeleton 2
cytosol 2
endosome 2
lysosome 2
mitochondrion 2
vacuole 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ICAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IEA --
GO:0005615 extracellular space IDA 9290466
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2538243
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with ICAM1: view

Pathways & Interactions for ICAM1 Gene

genes like me logo Genes that share pathways with ICAM1: view

PCR Array Products

SIGNOR curated interactions for ICAM1 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ICAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0001666 response to hypoxia --
GO:0001910 regulation of leukocyte mediated cytotoxicity TAS 16038038
GO:0001975 response to amphetamine IEA --
GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP 2477710
genes like me logo Genes that share ontologies with ICAM1: view

Drugs & Compounds for ICAM1 Gene

(71) Drugs for ICAM1 Gene - From: NovoSeek, DrugBank, HMDB, DGIdb, ApexBio, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronan Approved Pharma Target 328
Methimazole Approved Pharma ICAM-1 inhibitor 0
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 482
Natalizumab Approved, Investigational Pharma Target 0
Allopurinol Approved Pharma 125

(70) Additional Compounds for ICAM1 Gene - From: NovoSeek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ac2-12
256447-08-2
Ac2-26
151988-33-9
GR 144053 trihydrochloride
1215333-48-4
Thiolutin
  • Acetopyrrothine
  • Farcinicine
  • N-Acetylpyrrothine
  • Thiolutin
87-11-6
11-Deoxy-PGE1
genes like me logo Genes that share compounds with ICAM1: view

Transcripts for ICAM1 Gene

Unigene Clusters for ICAM1 Gene

Intercellular adhesion molecule 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ICAM1

Clone Products

  • Addgene plasmids for ICAM1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ICAM1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - -
SP2: - - -
SP3: - - - - - - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for ICAM1 Gene

GeneLoc Exon Structure for
ICAM1
ECgene alternative splicing isoforms for
ICAM1

Expression for ICAM1 Gene

mRNA expression in normal human tissues for ICAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ICAM1 Gene

This gene is overexpressed in Lung (x7.6).

Protein differential expression in normal tissues from HIPED for ICAM1 Gene

This gene is overexpressed in Spleen (11.4), Lymph node (10.0), and Lung (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ICAM1 Gene



SOURCE GeneReport for Unigene cluster for ICAM1 Gene Hs.643447

genes like me logo Genes that share expression patterns with ICAM1: view

Protein tissue co-expression partners for ICAM1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ICAM1 Gene

Orthologs for ICAM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ICAM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ICAM1 35
  • 68.91 (n)
  • 56.72 (a)
ICAM1 36
  • 55 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ICAM1 35
  • 72.96 (n)
  • 62.23 (a)
ICAM1 36
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Icam1 35
  • 64.77 (n)
  • 54.81 (a)
Icam1 16
Icam1 36
  • 51 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ICAM1 35
  • 98.5 (n)
  • 96.99 (a)
ICAM1 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Icam1 35
  • 63.46 (n)
  • 53.44 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 29 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
Species with no ortholog for ICAM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ICAM1 Gene

ENSEMBL:
Gene Tree for ICAM1 (if available)
TreeFam:
Gene Tree for ICAM1 (if available)

Paralogs for ICAM1 Gene

Paralogs for ICAM1 Gene

(5) SIMAP similar genes for ICAM1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ICAM1 Gene

genes like me logo Genes that share paralogs with ICAM1: view

Variants for ICAM1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ICAM1 Gene

P05362-ICAM1_HUMAN
Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria [MIM:611162]

Sequence variations from dbSNP and Humsavar for ICAM1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
VAR_010204 -, -
VAR_014186 -
VAR_014187 -
VAR_014651 -
VAR_014652 -

Structural Variations from Database of Genomic Variants (DGV) for ICAM1 Gene

Variant ID Type Subtype PubMed ID
nsv911029 CNV Loss 21882294
nsv911030 CNV Loss 21882294
dgv3725n71 CNV Loss 21882294
nsv911033 CNV Gain 21882294
nsv911034 CNV Gain 21882294
dgv3726n71 CNV Loss 21882294

Variation tolerance for ICAM1 Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.05; 75.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ICAM1 Gene

HapMap Linkage Disequilibrium report
ICAM1
Human Gene Mutation Database (HGMD)
ICAM1

Disorders for ICAM1 Gene

MalaCards: The human disease database

(114) MalaCards diseases for ICAM1 Gene - From: OMIM, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
malaria
  • malaria, severe
lethal midline granuloma
  • malignant granuloma of face
leukostasis
anoxia
oral lichen planus
  • oral lichenoid lesions
- elite association
Search ICAM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ICAM1

Genetic Association Database (GAD)
ICAM1
Human Genome Epidemiology (HuGE) Navigator
ICAM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ICAM1
genes like me logo Genes that share disorders with ICAM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ICAM1 Gene

Publications for ICAM1 Gene

  1. TCEAL7, a putative tumor suppressor gene, negatively regulates NF- kappaB pathway. (PMID: 19966855) Rattan R. … Shridhar V. (Oncogene 2010) 23 67
  2. Induction of ICAM-1 by Armillariella mellea is mediated through generation of reactive oxygen species and JNK activation. (PMID: 20079413) Kim Y.S. … Han S.H. (J Ethnopharmacol 2010) 23 67
  3. Corticosteroids and montelukast: effects on airway epithelial and human umbilical vein endothelial cells. (PMID: 20082198) Andersson K. … Servetnyk Z. (Lung 2010) 23 67
  4. miR-221 suppresses ICAM-1 translation and regulates interferon-gamma-induced ICAM-1 expression in human cholangiocytes. (PMID: 20110463) Hu G. … Chen X.M. (Am. J. Physiol. Gastrointest. Liver Physiol. 2010) 23 67
  5. HUVEC ICAM-1 and VCAM-1 synthesis in response to potentially athero-prone and athero-protective mechanical and nicotine chemical stimuli. (PMID: 20162355) Breen L.T. … Murphy B.P. (Ann Biomed Eng 2010) 23 67

Products for ICAM1 Gene

  • Addgene plasmids for ICAM1

Sources for ICAM1 Gene

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