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ICAM1 Gene

protein-coding GIFtS: 72

GC19P010247

intercellular adhesion molecule 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BB2 ^¹, ²
CD54 ^¹, ²
ICAM-1 ^³
P3.58 ^²

Descriptions
CD54 antigen ^³
Major group rhinovirus receptor ^³
cell surface glycoprotein P3.58 ^²
human rhinovirus receptor ^²
intercellular adhesion molecule 1 ^²
intercellular adhesion molecule 1 (CD54), human rhinovirus receptor ^²

External Ids
HGNC: 5344¹
Entrez Gene: 3383²
UniProtKB: P05362³
Ensembl: ENSG00000090339⁷

Search outside databases for aliases for ICAM1 gene

Previous GC identifers: GC19P010503 GC19P010604 GC19P010226 GC19P010243 GC19P010244

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ICAM1:

This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and

cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is

also exploited by Rhinovirus as a receptor. [provided by RefSeq]

UniProtKB/Swiss-Prot: ICAM1_HUMAN, P05362

Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin

alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the

assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus

infection acts as a cellular receptor for the virus

Gene Wiki entry for ICAM1 (ICAM-1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ICAM1 gene

Entrez Gene cytogenetic band: 19p13.3-p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.3-p13.2

ICAM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P010247: (about GC identifiers)

Start:	10,242,765 bp from pter
End:	10,258,291 bp from pter
Size:	15,527 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011295.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ICAM1_HUMAN, P05362 (See protein sequence)

Recommended Name: Intercellular adhesion molecule 1 precursor

Size: 532 amino acids; 57825 Da

Subunit: Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable).

Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with SGEF. Binds

to coxsackievirus A21 capsid proteins and acts as a receptor for this virus

Subcellular location: Membrane; Single-pass type I membrane protein

PDB structures from and Proteopedia :

1D3E (3D)

1D3I (3D)

1D3L (3D)

1IAM (3D)

1IC1 (3D)

1IJ4 (3D)

1MQ8 (3D)

1P53 (3D)

1Z7Z (3D)

2OZ4 (3D)

Secondary accessions: Q5NKV7 Q96B50

Post-translational modifications:

Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000192.2

ENSEMBL proteins:

ENSP00000264832

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for ICAM1 (ICAM-1/CD54)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ICAM1, CD8 + CD54, CD3 + CD54)
	Human Recombinant Proteins from Abnova (ICAM1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IDA	9290466
GO:0005737	cytoplasm	IDA	18029348
GO:0005886	plasma membrane	NAS	3349522
GO:0005887	integral to plasma membrane	TAS	2538243
GO:0009897	external side of plasma membrane	IEA	--

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Antibodies for ICAM1:

	Invitrogen Antibodies for ICAM1
	Millipore Mono- and Polyclonal Antibodies for the study of ICAM1
	Sigma-Aldrich Antibodies for ICAM1
	R&D Systems Antibodies for ICAM1 (ICAM-1/CD54)
	Antibodies from Abcam (ICAM1, CD8 + CD54, CD3 + CD54), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ICAM1)
	Novus Biologicals Antibodies for ICAM1

Assays for ICAM1:

	Invitrogen Assays for ICAM1
	Millipore Kits and Assays for the Analysis of ICAM1
	R&D Systems ELISAs for ICAM1 (ICAM-1/CD54) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P05362

ProtoNet protein and cluster: P05362

4 Blocks protein families:

IPB003599 Immunoglobulin subtype

IPB003987 Intercellular adhesion molecule/vascular cell adhesion molecule-1 signature

IPB003988 Intercellular adhesion molecule (ICAM) family signature

IPB013768 Intercellular adhesion molecule

UniProtKB/Swiss-Prot: ICAM1_HUMAN, P05362

Similarity: Belongs to the immunoglobulin superfamily. ICAM family

Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ICAM1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ICAM1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000201

Applied Biosystems Silencer® siRNAs for ICAM1

Sigma-Aldrich siRNA and siRNA Panels for ICAM1

Sigma-Aldrich shRNA Panels and shRNA for ICAM1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ICAM1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000201
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000201
untagged cDNA clone in CMV expression vector: NM_000201

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000201

UniProtKB/Swiss-Prot: ICAM1_HUMAN, P05362

Function: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin

alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the

assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus

infection acts as a cellular receptor for the virus

Genatlas biochemistry entry for ICAM1:

adhesion molecule,intercellular 1,ligand for LFA1 (CD11A/CD18),expressed on vascular endothelium

and leukocytes,up-regulated by cytokines,inhibiting interleukin 4 production by naive T cells,also

interacting with ezrin VIL2 and ICAM2 in microvillar projections under phosphatidylinositol-4,5

biphosphate regulation,human rhinovirus receptor with some allele(s) predisposing to cerebral

malaria,also contributing to multiple sclerosis susceptibility

14 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Icam1):

	cellular	digestive/alimentary	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	immune system	life span-post-weaning/aging	muscle
nervous system	skin/coat/nails	tumorigenesis	vision/eye

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004888	transmembrane receptor activity	TAS	2538243
GO:0005178	integrin binding	IPI	1448173
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/8 Sigma-Aldrich "Your Favorite Gene" Pathways for ICAM1 (Your Favorite Gene powered by Ingenuity) (see all 8 )

Glucocorticoid Receptor Signaling
IL-8 Signaling
CD40 Signaling
Leukocyte Extravasation Signaling
TREM1 Signaling

GeneDecks ICAM1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ICAM1

5/268 Interacting proteins for ICAM1 (ENSP00000264832³ P05362²) via UniProtKB, MINT, and/or STRING (see all 268 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RPS27A	P62988²	MINT-4053108
RPS27AP11	P62988²	MINT-4053108
RPS27AP12	P62988²	MINT-4053108
RPS27AP16	P62988²	MINT-4053108
UBA52	P62988²	MINT-4053108

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5/13 Gene Ontology (GO) biological process terms (links to tree view) (see all 13 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001910	regulation of leukocyte mediated cytotoxicity	TAS	16038038
GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IMP	2477710
GO:0002457	T cell antigen processing and presentation	IEA	--
GO:0002693	positive regulation of cellular extravasation	IMP	12902516
GO:0007157	heterophilic cell adhesion	TAS	2477710

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for ICAM1 available from Tocris Bioscience

Compound	Action	CAS number
A 205804	Selective inhibitor of E-selectin and ICAM-1 expression	[251992-66-2]

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10/31 Novoseek chemical compound relationships for ICAM1 gene (see all 31 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	64.84	95	12506144 (4), 12558634 (4), 9625753 (3), 9848225 (3) (see all 60)
slex	57.86	30	9430509 (3), 14507735 (2), 15187162 (2), 8547121 (1) (see all 20)
enlimomab	55.94	3	10096530 (1), 11673584 (1), 9973515 (1)
lfa703	53.20	3	15618295 (2), 17482516 (1)
fibrinogen	52.20	211	10712387 (7), 15189898 (6), 10903502 (6), 8995280 (5) (see all 86)
maltose 1-phosphate	48.90	2	9543101 (2)
fmlp	44.50	19	15550998 (2), 12234777 (2), 12610322 (2), 14723618 (2) (see all 10)
groalpha	43.47	7	16687566 (3), 11163401 (1), 11566005 (1), 16858424 (1) (see all 5)
phorbol	42.07	13	9765268 (2), 8103344 (1), 8703996 (1), 9770366 (1) (see all 11)
cps-m	41.08	1	2124247 (1)

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1 PharmGKB drug compound relationship for ICAM1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
glucocorticoids	FA	12729843

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ICAM1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ICAM1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000201

Sigma-Aldrich siRNA and siRNA Panels for ICAM1

Sigma-Aldrich shRNA Panels and shRNA for ICAM1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000201

REFSEQ mRNAs for ICAM1 gene:

NM_000201.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000201

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000201
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000201
                                 untagged cDNA clone in CMV expression vector: NM_000201

Additional cDNA sequence:

AF340038.1 AF340039.1 AK130659.1 AK298054.1 AK298983.1 AK301412.1 AK312636.1 BC015969.2

BT006854.1 CR617464.1 J03132.1 M24283.1 M55038.1 S82847.1 X06990.1

15 DOTS entries:

DT.87016703 DT.95145860 DT.100821617 DT.92444106 DT.121464281 DT.95157958 DT.100821620 DT.121464277

DT.95229577 DT.121464141 DT.121464225 DT.121464232 DT.121464260 DT.92444125 DT.95282573

24/282 AceView cDNA sequences (see all 282 ):

BI823891 CF126469 NM_022377 NM_001544 AU279886 BM855025 BC000046 BQ961824

BQ678186 AU104806 BI772468 CB265238 BG945719 BU192598 BP351585 CB529024

AU133164 CK429562 BM473834 AA306799 AU099232 AL545876 CB529704 BQ678437

highest scoring ESTs for ICAM1:

M24283 AA197311 AA306799 AA314976 AA367199 AI078051 AI380729 AI432669 AI608725 AI753027

Unigene Cluster for ICAM1:

Intercellular adhesion molecule 1

Hs.643447 [show with all ESTs]

Unigene Representative Sequence: NM_000201

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ICAM1 (see all 6 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8a	·	8b	·	8c	^	9a	·	9b	^	10a	·	10b	·	10c
SP1:													-		-
SP2:									-				-		-
SP3:											-		-		-		-		-		-		-		-		-
SP4:													-		-		-
SP5:																																	-

About this scheme

ECgene alternative splicing isoforms for ICAM1

1 Ensembl transcript including schematic representation:

ENST00000264832

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ICAM1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ICAM1

¹ / ² / ³

7 probe-sets matching ICAM1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32640_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M24283	1.00	1.00	1.00	1
202637_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI608725	0.80	1.00	0.91	1
215485_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA284705	0.60	1.00	0.82	1
202638_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000201	0.60	1.00	0.82	1
202637_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215485_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202638_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ICAM1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTTCACTGCA

SOURCE GeneReport for Unigene cluster: Hs.643447
Expression variation in blood from EXPOLDB for ICAM1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ICAM1 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ICAM1¹	--	intercellular adhesion molecule 1	73.52(n) 62.83(a)	403975 XM_542075.2 XP_542075.2
chimpanzee (Pan troglodytes)	ICAM1¹	--	intercellular adhesion molecule 1	98.43(n) 96.8(a)	450196 NM_001009946.1 NP_001009946.1
cow (Bos taurus)	ICAM1¹	--	intercellular adhesion molecule 1	69.19(n) 56.71(a)	281839 NM_174348.2 NP_776773.1
rat (Rattus norvegicus)	Icam1¹	--	intercellular adhesion molecule 1	63.64(n) 53.31(a)	25464 NM_012967.1 NP_037099.1
mouse (Mus musculus)	Icam1^{1, 5}	9 (7.00 cM)⁵	intercellular adhesion molecule 1^{1, 5}	64.71(n)¹ 54.25(a)¹	15894¹ NM_010493.2¹ NP_034623.1¹ AK149748⁵ AK149781⁵ (see all 36)

About this table Species with no ortholog for ICAM1

ENSEMBL Gene Tree for ICAM1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ICAM1 gene

ICAM5² ICAM2² ICAM3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: ICAM1_HUMAN, P05362

Polymorphism: Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral

malaria

10/140 NCBI SNPs in ICAM1 are shown (see all 140 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 95)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs5491^1,2	C,F,H,O	10246540(+)	`GCCCAA/TGTTGT`	1	K/M	mis¹ ese³		30	MN CSAM EA EU WA NS NA	2654
	rs5490^1,2	C,F,H,O	10242827(+)	`ACCTCA/CGCCTC`	1	--	ut5¹ ese³		14	MN NS CSAM EA EU WA NA	1220
	rs5497^1,2	C,F,H	10256468(+)	`CCCCCG/AACTGG`	1	Q/R	mis¹ ese³		18	MN NS CSAM EA EU WA NA	1668
--	rs1799969^1,2	C,F,H	10255792(+)	`TGGACG/AGGCTG`	1	R/G	mis¹ ese³		23	MN NS NA EU EA WA CSAM	1974
--	rs5030339^1,2	C,F,H	10241137(+)	`TGGGAG/ACCGCG`	1	--	ng5¹		6	NS EU EA WA	490
--	rs5030388^1,2	C,F	10241673(+)	`GGAAAG/ACCTTA`	1	--	ng5¹		7	NS MN CSAM EA	490
	rs13306427^1,2	C,H	10242792(+)	`GTCGAC/TGCTGA`	1	--	ut5¹ ese³		9	MN CSAM EA EU WA	824
	rs1801714^1,2	C,F	10256208(+)	`GGGCCC/TGAGGG`	1	P/L	mis¹ ese³		6	MN NS NA	400
	rs13306430^1,2	H	10256624(+)	`CACTCG/AAGATC`	1	Q/R	mis¹ ese³		4	EU EA WA	418
	rs5492^1,2	H	10255290(+)	`GAGAAG/CGAGCT`	1	N/K	mis¹ trp³		6	MN EU EA WA	674

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HapMap Linkage Disequilibrium images for ICAM1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 147840 disorders: 611162

10/96 Novoseek disease relationships for ICAM1 gene (see all 96 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation	82.41	466	15037117 (4), 7912141 (3), 7512004 (3), 7524087 (3) (see all 99)
necrosis	81.62	691	8104967 (3), 17452936 (3), 15764154 (3), 1974275 (2) (see all 99)
atherosclerosis	69.12	104	18420209 (4), 9416885 (3), 12425201 (2), 9187938 (2) (see all 75)
tumors	68.61	994	8605704 (7), 10738180 (6), 10090402 (5), 12149643 (5) (see all 99)
malaria cerebral	60.95	16	7650476 (2), 9259284 (2), 9502610 (1), 9861406 (1) (see all 13)
psoriasis	53.83	37	7902785 (4), 8867647 (2), 7521104 (2), 9749989 (1) (see all 27)
melanoma	51.65	320	1347555 (7), 9241963 (7), 7915992 (6), 1284075 (6) (see all 99)
rheumatoid arthritis	49.22	44	7911453 (2), 8856611 (2), 18475445 (2), 7897232 (2) (see all 32)
graves disease	48.46	55	1348415 (4), 11578685 (3), 9343311 (3), 7626551 (3) (see all 32)
asthma	47.93	130	11144049 (4), 9111502 (3), 7802929 (3), 1967851 (3) (see all 74)

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Human Gene Mutation Database: ICAM1
Genetic Association Database: ICAM1
Human Genome Epidemiology Navigator: ICAM1 (143 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/3562 PubMed articles for ICAM1 gene (see all 3562 ):

Polymorphisms of the ICAM-1 gene are associated with inflammatory bowel disease, regardless of the p-ANCA status. (PubMed id 11726228)^{1, 3, 6} Braun C....Folwaczny C. (2001)
ICAM-1 polymorphisms and development of cutaneous malignant melanoma. (PubMed id 16313300)^{1, 3, 6} Howell W.M....Bateman A.C. (2005)
Influence of cytokine and ICAM-1 gene polymorphisms on susceptibility to chronic pancreatitis. (PubMed id 15917409)^{1, 3, 6} Howell W.M....Bateman A.C. (2005)
Intercellular adhesion molecule-1 (ICAM-1) polymorphism is associated with diabetic retinopathy in Type 2 diabetes mellitus. (PubMed id 12027924)^{1, 3, 6} Kamiuchi K....Nakamura N. (2002)
A high frequency African coding polymorphism in the N-terminal domain of ICAM-1 predisposing to cerebral malaria in Kenya. (PubMed id 9259284)^{1, 3, 4} Fernandez-Reyes D.... Newbold C.I. (1997)
Gene polymorphisms and serological markers of patients with active Crohn's disease in a clinical trial of antisense to ICAM-1. (PubMed id 15958080)^{1, 3, 6} Yacyshyn B.R....Tami J.A. (2005)
Plasmodium falciparum malaria in south-west Nigerian children: is the polymorphism of ICAM-1 and E-selectin genes contributing to the clinical severity of malaria? (PubMed id 16002039)^{1, 3, 6} Amodu O.K....Omotade O.O. (2005)
ICAM G241A polymorphism and soluble ICAM-1 serum levels: evidence for an active immune process in schizophrenia. (PubMed id 15756053)^{1, 3, 6} Kronig H....Muller N. (2005)
Intercellular adhesion molecule 1 (ICAM-1) gene variant is associated with coronary artery calcification independent of soluble ICAM-1 levels. (PubMed id 15682683)^{1, 3, 6} Reilly M.P....Rader D.J. (2004)
Inflammatory bowel disease is linked to 19p13 and associated with ICAM-1. (PubMed id 15290909)^{1, 3, 6} Low J.H....Jewell D.P. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 3383	HGNC: 5344	AceView: ICAM1andICAM4	Ensembl:ENSG00000090339	euGenes: HUgn3383
ECgene: ICAM1	H-InvDB: ICAM1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ICAM1	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/icam1/

Licensable Technologies for ICAM1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ICAM1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ICAM1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ICAM1		Antibodies for ICAM1
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	Lentivirus-delivered shRNAs for ICAM1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ICAM1)
	Antibodies (ICAM1)
	Chimera RNAi (ICAM1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (ICAM1, CD8 + CD54, CD3 + CD54)
	Antibodies (ICAM1, CD8 + CD54, CD3 + CD54)

Search OriGene for ICAM1

Tocris compounds for ICAM1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ICAM1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ICAM1 Gene at Home site.
Version 2.41.1
server4.xennexinc.com

ICAM1 Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for ICAM1

Summaries
for ICAM1

Genomic Location
for ICAM1

Proteins
for ICAM1

Protein Domains/
Families
for ICAM1

Gene Function
for ICAM1

Pathways & Interactions
for ICAM1

Drugs & Compounds
for ICAM1

Transcripts
for ICAM1

Expression
for ICAM1

Orthologs
for ICAM1

Paralogs
for ICAM1

SNPs/Variants
for ICAM1

Disorders & Mutations
for ICAM1

Medical News
for ICAM1

Publications
for ICAM1

Search for ICAM1

Genome Databases showing ICAM1

Other Databases showing ICAM1

Specialized Databases showing ICAM1

Licensable Technologies
for ICAM1

Services
for ICAM1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ICAM1 Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor ICAM1

Summariesfor ICAM1

Genomic Locationfor ICAM1

Proteinsfor ICAM1

Protein Domains/Familiesfor ICAM1

Gene Functionfor ICAM1

Pathways & Interactionsfor ICAM1

Drugs & Compoundsfor ICAM1

Transcriptsfor ICAM1

Expression for ICAM1

Orthologsfor ICAM1

Paralogsfor ICAM1

SNPs/Variantsfor ICAM1

Disorders & Mutationsfor ICAM1

Medical Newsfor ICAM1

Publicationsfor ICAM1

Search for ICAM1

Genome Databases showing ICAM1

Other Databases showing ICAM1

Specialized Databases showing ICAM1

Licensable Technologiesfor ICAM1

Servicesfor ICAM1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ICAM1

Summaries
for ICAM1

Genomic Location
for ICAM1

Proteins
for ICAM1

Protein Domains/
Families
for ICAM1

Gene Function
for ICAM1

Pathways & Interactions
for ICAM1

Drugs & Compounds
for ICAM1

Transcripts
for ICAM1

Expression
for ICAM1

Orthologs
for ICAM1

Paralogs
for ICAM1

SNPs/Variants
for ICAM1

Disorders & Mutations
for ICAM1

Medical News
for ICAM1

Publications
for ICAM1

Licensable Technologies
for ICAM1

Services
for ICAM1