Aliases for ICAM1 Gene
External Ids for ICAM1 Gene
Previous GeneCards Identifiers for ICAM1 Gene
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
GeneCards Summary for ICAM1 Gene
ICAM1 (Intercellular Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with ICAM1 include lethal midline granuloma and dissecting cellulitis of the scalp. Among its related pathways are Class I MHC mediated antigen processing and presentation and Integrin Pathway. GO annotations related to this gene include receptor activity and integrin binding. An important paralog of this gene is ICAM2.
UniProtKB/Swiss-Prot for ICAM1 Gene
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.