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Aliases for ICA1L Gene

Aliases for ICA1L Gene

  • Islet Cell Autoantigen 1,69kDa-Like 2 3
  • Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 14 Protein 3 4
  • Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 15 Protein 3 4
  • Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 15 2 3
  • Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 14 2 3
  • ALS2CR14 3 4
  • ALS2CR15 3 4
  • Islet Cell Autoantigen 1-Like Protein 3
  • Ica69-Related Protein 3

External Ids for ICA1L Gene

Previous HGNC Symbols for ICA1L Gene

  • ALS2CR15
  • ALS2CR14

Previous GeneCards Identifiers for ICA1L Gene

  • GC02M203350
  • GC02M203639
  • GC02M195484

Summaries for ICA1L Gene

GeneCards Summary for ICA1L Gene

ICA1L (Islet Cell Autoantigen 1,69kDa-Like) is a Protein Coding gene. Diseases associated with ICA1L include lateral sclerosis. GO annotations related to this gene include protein domain specific binding. An important paralog of this gene is ICA1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICA1L Gene

Genomics for ICA1L Gene

Regulatory Elements for ICA1L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ICA1L Gene

Start:
202,773,150 bp from pter
End:
202,871,985 bp from pter
Size:
98,836 bases
Orientation:
Minus strand

Genomic View for ICA1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ICA1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICA1L Gene

Proteins for ICA1L Gene

  • Protein details for ICA1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDH6-ICA1L_HUMAN
    Recommended name:
    Islet cell autoantigen 1-like protein
    Protein Accession:
    Q8NDH6
    Secondary Accessions:
    • B3KRW6
    • Q53P45
    • Q53QZ4
    • Q53T97
    • Q96N47
    • Q96Q32
    • Q9BVQ2

    Protein attributes for ICA1L Gene

    Size:
    482 amino acids
    Molecular mass:
    54407 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ICA1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ICA1L Gene

Proteomics data for ICA1L Gene at MOPED

Post-translational modifications for ICA1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ICA1L Gene

Domains for ICA1L Gene

Suggested Antigen Peptide Sequences for ICA1L Gene

Graphical View of Domain Structure for InterPro Entry

Q8NDH6

UniProtKB/Swiss-Prot:

ICA1L_HUMAN :
  • Q8NDH6
Domain:
  • Contains 1 AH domain.
genes like me logo Genes that share domains with ICA1L: view

No data available for Gene Families for ICA1L Gene

Function for ICA1L Gene

Gene Ontology (GO) - Molecular Function for ICA1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with ICA1L: view
genes like me logo Genes that share phenotypes with ICA1L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ICA1L

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ICA1L Gene

Localization for ICA1L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ICA1L Gene COMPARTMENTS Subcellular localization image for ICA1L gene
Compartment Confidence
cytosol 3
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ICA1L Gene

Pathways for ICA1L Gene

SuperPathways for ICA1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for ICA1L Gene

None

No data available for Pathways by source for ICA1L Gene

Transcripts for ICA1L Gene

Unigene Clusters for ICA1L Gene

Islet cell autoantigen 1,69kDa-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ICA1L

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ICA1L Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - -
SP2: -
SP3: -
SP4: - -
SP5: -

Relevant External Links for ICA1L Gene

GeneLoc Exon Structure for
ICA1L
ECgene alternative splicing isoforms for
ICA1L

Expression for ICA1L Gene

mRNA expression in normal human tissues for ICA1L Gene

mRNA differential expression in normal tissues according to GTEx for ICA1L Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ICA1L Gene

SOURCE GeneReport for Unigene cluster for ICA1L Gene Hs.516629

genes like me logo Genes that share expressions with ICA1L: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ICA1L Gene

Orthologs for ICA1L Gene

This gene was present in the common ancestor of animals.

Orthologs for ICA1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ICA1L 35
  • 99.18 (n)
  • 99.18 (a)
ICA1L 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ICA1L 35
  • 88.63 (n)
  • 84.41 (a)
ICA1L 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ICA1L 35
  • 90.71 (n)
  • 87.73 (a)
ICA1L 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ica1l 35
  • 84.42 (n)
  • 82.24 (a)
Ica1l 16
Ica1l 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ICA1L 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ICA1L 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ica1l 35
  • 83.56 (n)
  • 80.18 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.17431 35
ical1 35
  • 62.49 (n)
  • 61.94 (a)
ical1 36
  • 45 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006627 35
  • 51.09 (n)
  • 45.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10566 35
  • 51.64 (n)
  • 47.54 (a)
CG10566 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ric-19 36
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9836 36
  • 28 (a)
OneToMany
Species with no ortholog for ICA1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ICA1L Gene

ENSEMBL:
Gene Tree for ICA1L (if available)
TreeFam:
Gene Tree for ICA1L (if available)

Paralogs for ICA1L Gene

Paralogs for ICA1L Gene

genes like me logo Genes that share paralogs with ICA1L: view

Variants for ICA1L Gene

Sequence variations from dbSNP and Humsavar for ICA1L Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs10870 -- 202,774,142(-) ACAAA(C/T)GAATT utr-variant-3-prime
rs735039 -- 202,843,428(+) GTGGC(A/G)CAAGA intron-variant
rs934287 -- 202,843,584(+) GATGC(A/G)CAAAT intron-variant
rs1199351 -- 202,864,974(-) gttgg(C/T)caggc intron-variant
rs1344959 -- 202,825,664(+) ATGGG(A/G)ATTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ICA1L Gene

Variant ID Type Subtype PubMed ID
nsv460020 CNV Gain 19166990
nsv470510 CNV Gain 18288195
nsv875715 CNV Loss 21882294

Relevant External Links for ICA1L Gene

HapMap Linkage Disequilibrium report
ICA1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ICA1L Gene

Disorders for ICA1L Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ICA1L Gene including...

Search for ICA1L Gene in MalaCards »

Relevant External Links for ICA1L

Genetic Association Database (GAD)
ICA1L
Human Genome Epidemiology (HuGE) Navigator
ICA1L
genes like me logo Genes that share disorders with ICA1L: view

No data available for UniProtKB/Swiss-Prot for ICA1L Gene

Publications for ICA1L Gene

  1. A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. (PMID: 11586298) Hadano S. … Ikeda J.-E. (Nat. Genet. 2001) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for ICA1L Gene

Sources for ICA1L Gene

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