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Aliases for ICA1L Gene

Aliases for ICA1L Gene

  • Islet Cell Autoantigen 1 Like 2 3 5
  • Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 14 Protein 3 4
  • Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 15 Protein 3 4
  • Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 15 2 3
  • Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 14 2 3
  • Islet Cell Autoantigen 1,69kDa-Like 2 3
  • ALS2CR14 3 4
  • ALS2CR15 3 4
  • Ica69-Related Protein 3

External Ids for ICA1L Gene

Previous HGNC Symbols for ICA1L Gene

  • ALS2CR15
  • ALS2CR14

Previous GeneCards Identifiers for ICA1L Gene

  • GC02M203350
  • GC02M203639
  • GC02M195484
  • GC02M202777
  • GC02M202780

Summaries for ICA1L Gene

GeneCards Summary for ICA1L Gene

ICA1L (Islet Cell Autoantigen 1 Like) is a Protein Coding gene. Diseases associated with ICA1L include Amyotrophic Lateral Sclerosis 2, Juvenile. GO annotations related to this gene include protein domain specific binding. An important paralog of this gene is ICA1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICA1L Gene

Genomics for ICA1L Gene

Regulatory Elements for ICA1L Gene

Enhancers for ICA1L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ICA1L on UCSC Golden Path with GeneCards custom track

Promoters for ICA1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ICA1L on UCSC Golden Path with GeneCards custom track

Genomic Location for ICA1L Gene

202,773,150 bp from pter
202,871,985 bp from pter
98,836 bases
Minus strand

Genomic View for ICA1L Gene

Genes around ICA1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ICA1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ICA1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICA1L Gene

Proteins for ICA1L Gene

  • Protein details for ICA1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Islet cell autoantigen 1-like protein
    Protein Accession:
    Secondary Accessions:
    • B3KRW6
    • Q53P45
    • Q53QZ4
    • Q53T97
    • Q96N47
    • Q96Q32
    • Q9BVQ2

    Protein attributes for ICA1L Gene

    482 amino acids
    Molecular mass:
    54407 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ICA1L Gene


neXtProt entry for ICA1L Gene

Proteomics data for ICA1L Gene at MOPED

Post-translational modifications for ICA1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ICA1L Gene

Domains & Families for ICA1L Gene

Suggested Antigen Peptide Sequences for ICA1L Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 AH domain.
  • Contains 1 AH domain.
genes like me logo Genes that share domains with ICA1L: view

No data available for Gene Families for ICA1L Gene

Function for ICA1L Gene

Gene Ontology (GO) - Molecular Function for ICA1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ICA1L: view
genes like me logo Genes that share phenotypes with ICA1L: view

Animal Model Products

miRNA for ICA1L Gene

miRTarBase miRNAs that target ICA1L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ICA1L Gene

Localization for ICA1L Gene

Subcellular locations from

Jensen Localization Image for ICA1L Gene COMPARTMENTS Subcellular localization image for ICA1L gene
Compartment Confidence
cytosol 3
mitochondrion 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ICA1L Gene

Pathways & Interactions for ICA1L Gene

SuperPathways for ICA1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for ICA1L Gene


No data available for Pathways by source and SIGNOR curated interactions for ICA1L Gene

Drugs & Compounds for ICA1L Gene

No Compound Related Data Available

Transcripts for ICA1L Gene

Unigene Clusters for ICA1L Gene

Islet cell autoantigen 1,69kDa-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ICA1L Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - -
SP2: -
SP3: -
SP4: - -
SP5: -

Relevant External Links for ICA1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ICA1L Gene

mRNA expression in normal human tissues for ICA1L Gene

mRNA differential expression in normal tissues according to GTEx for ICA1L Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.2).

Protein differential expression in normal tissues from HIPED for ICA1L Gene

This gene is overexpressed in Plasma (60.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ICA1L Gene

SOURCE GeneReport for Unigene cluster for ICA1L Gene Hs.516629

genes like me logo Genes that share expression patterns with ICA1L: view

Protein tissue co-expression partners for ICA1L Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ICA1L Gene

Orthologs for ICA1L Gene

This gene was present in the common ancestor of animals.

Orthologs for ICA1L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ICA1L 35
  • 88.63 (n)
  • 84.41 (a)
ICA1L 36
  • 84 (a)
(Canis familiaris)
Mammalia ICA1L 35
  • 90.71 (n)
  • 87.73 (a)
ICA1L 36
  • 86 (a)
(Mus musculus)
Mammalia Ica1l 35
  • 84.42 (n)
  • 82.24 (a)
Ica1l 16
Ica1l 36
  • 80 (a)
(Pan troglodytes)
Mammalia ICA1L 35
  • 99.18 (n)
  • 99.18 (a)
ICA1L 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Ica1l 35
  • 83.56 (n)
  • 80.18 (a)
(Monodelphis domestica)
Mammalia ICA1L 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia ICA1L 36
  • 69 (a)
(Danio rerio)
Actinopterygii Dr.17431 35
ical1 35
  • 62.49 (n)
  • 61.94 (a)
ical1 36
  • 45 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006627 35
  • 51.09 (n)
  • 45.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10566 35
  • 51.64 (n)
  • 47.54 (a)
CG10566 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea ric-19 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9836 36
  • 28 (a)
Species with no ortholog for ICA1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ICA1L Gene

Gene Tree for ICA1L (if available)
Gene Tree for ICA1L (if available)

Paralogs for ICA1L Gene

Paralogs for ICA1L Gene

genes like me logo Genes that share paralogs with ICA1L: view

Variants for ICA1L Gene

Sequence variations from dbSNP and Humsavar for ICA1L Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs735039 -- 202,843,428(+) GTGGC(A/G)CAAGA intron-variant
rs1866423 -- 202,833,067(+) aaact(A/G)cttaa intron-variant
rs934287 -- 202,843,584(+) GATGC(A/G)CAAAT intron-variant
rs1971819 -- 202,841,064(+) TCCAA(C/G)ATCTG intron-variant
rs3050869 -- 202,860,293(+) TAATA(-/ATAATG)ATAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ICA1L Gene

Variant ID Type Subtype PubMed ID
nsv460020 CNV Gain 19166990
nsv470510 CNV Gain 18288195
nsv875715 CNV Loss 21882294

Variation tolerance for ICA1L Gene

Residual Variation Intolerance Score: 58.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.90% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ICA1L Gene

Disorders for ICA1L Gene

MalaCards: The human disease database

(1) MalaCards diseases for ICA1L Gene - From: GeneCards

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 2, juvenile
  • als2
- elite association - COSMIC cancer census association via MalaCards
Search ICA1L in MalaCards View complete list of genes associated with diseases

Relevant External Links for ICA1L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ICA1L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ICA1L Gene

Publications for ICA1L Gene

  1. A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. (PMID: 11586298) Hadano S. … Ikeda J.-E. (Nat. Genet. 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ICA1L Gene

Sources for ICA1L Gene