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ICA1L Gene

protein-coding   GIFtS: 46
GCID: GC02M203639

Islet Cell Autoantigen 1,69kDa-Like

(Previous names: amyotrophic lateral sclerosis 2 (juvenile) chromosome region,...)
(Previous symbols: ALS2CR15, ALS2CR14)
  See ICA1L-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Islet Cell Autoantigen 1,69kDa-Like1 2     Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 14
Protein2 3
ALS2CR141 2 3     Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 15
Protein2 3
ALS2CR151 2 3     Ica69-Related Protein2
Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 141 2     Islet Cell Autoantigen 1-Like Protein2
Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 151 2     

External Ids:    HGNC: 144421   Entrez Gene: 1300262   Ensembl: ENSG000001635967   UniProtKB: Q8NDH63   

Export aliases for ICA1L gene to outside databases

Previous GC identifers: GC02M203350 GC02M195484


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ICA1L Gene:
ICA1L (islet cell autoantigen 1,69kDa-like) is a protein-coding gene. Diseases associated with ICA1L include lateral sclerosis, and amyotrophic lateral sclerosis. GO annotations related to this gene include protein domain specific binding. An important paralog of this gene is ICA1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the ICA1L gene promoter:
         SRF   SRF (504 AA)   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ICA1L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ICA1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33.2   Ensembl cytogenetic band:  2q33.2   HGNC cytogenetic band: 2q33

ICA1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ICA1L gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M203639:  view genomic region     (about GC identifiers)

Start:
203,637,873 bp from pter      End:
203,736,708 bp from pter
Size:
98,836 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ICA1L_HUMAN, Q8NDH6 (See protein sequence)
Recommended Name: Islet cell autoantigen 1-like protein  
Size: 482 amino acids; 54407 Da
Secondary accessions: B3KRW6 Q53P45 Q53QZ4 Q53T97 Q96N47 Q96Q32 Q9BVQ2
Alternative splicing: 2 isoforms:  Q8NDH6-1   Q8NDH6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ICA1L: NX_Q8NDH6

Explore proteomics data for ICA1L at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ICA1L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001275551.1  NP_001275552.1  NP_001275553.1  NP_612477.3  

    ENSEMBL proteins: 
     ENSP00000376070   ENSP00000351047   ENSP00000398916   ENSP00000400249   ENSP00000404189  
     ENSP00000412158   ENSP00000410747   ENSP00000405592   ENSP00000410135   ENSP00000404618  
     ENSP00000387382   ENSP00000398420   ENSP00000404707   ENSP00000397827   ENSP00000392609  
     ENSP00000416726   ENSP00000409741   ENSP00000414916  

    ICA1L Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ICA1L
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    Novus Biologicals ICA1L Protein
    Novus Biologicals ICA1L Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ICA1L

     
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    ICA1L Antibody Products:

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    ThermoFisher Antibodies for ICA1L
    LSBio Antibodies in human, mouse, rat for ICA1L

    ICA1L Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for ICA1L
    Cloud-Clone Corp. CLIAs for ICA1L
    Search eBioscience for ELISAs for ICA1L 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR024114 Islet_autoAg_Ica1/Ica1-like
     IPR027267 AH/BAR-dom
     IPR010504 AH_dom
     IPR006723 Islet_autoAg_Ica1_C

    Graphical View of Domain Structure for InterPro Entry Q8NDH6

    ProtoNet protein and cluster: Q8NDH6

    2 Blocks protein domains:
    IPB006723 Islet cell autoantigen ICA69 homologue
    IPB010504 Arfaptin-like


    UniProtKB/Swiss-Prot: ICA1L_HUMAN, Q8NDH6
    Similarity: Contains 1 AH domain


    Find genes that share domains with ICA1L           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019904protein domain specific binding IEA--
         
    Find genes that share ontologies with ICA1L           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for ICA1L:
     Decreased G3BP1 protein expres  Increased S DNA content  Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ICA1L
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ICA1L

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ICA1L
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ICA1L

    miRNA
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    Block miRNA regulation of human, mouse, rat ICA1L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ICA1L (see all 36):
    hsa-miR-607 hsa-miR-429 hsa-miR-500a hsa-miR-105 hsa-miR-4314 hsa-miR-409-5p hsa-miR-200b hsa-miR-647
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ICA1L

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): ICA1L (NM_138468)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ICA1L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICA1L

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICA1L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ICA1L
    Interactions:

        Search GeneGlobe Interaction Network for ICA1L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for ICA1L (Q8NDH63 ENSP000003510474) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PICK1Q9NRD53I2D: score=5 
    RPSAP088653I2D: score=5 
    UBE2E2Q96LR53I2D: score=5 
    ATP6V1B2ENSP000002763904STRING: ENSP00000276390
    BDH1ENSP000003509144STRING: ENSP00000350914
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ICA1L



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ICA1L gene (5 alternative transcripts): 
    NM_178231.2  NM_001288622.1  NM_001288623.1  NM_001288624.1  NM_138468.5  

    Unigene Cluster for ICA1L:

    Islet cell autoantigen 1,69kDa-like
    Hs.516629  [show with all ESTs]
    Unigene Representative Sequence: NM_138468
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000392237(uc002uzh.1 uc002uzi.1 uc021vvi.1) ENST00000358299
    ENST00000438804 ENST00000420558 ENST00000494560 ENST00000476602 ENST00000425178(uc002uzj.3)
    ENST00000418208 ENST00000450143 ENST00000435143 ENST00000419460 ENST00000441547
    ENST00000412210 ENST00000437978 ENST00000457524 ENST00000432273 ENST00000416760
    ENST00000454326
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ICA1L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ICA1L (see all 36):
    hsa-miR-607 hsa-miR-429 hsa-miR-500a hsa-miR-105 hsa-miR-4314 hsa-miR-409-5p hsa-miR-200b hsa-miR-647
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ICA1L
    Predesigned siRNA for gene silencing in human, mouse, rat ICA1L
    Clone
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    OriGene clones in human, mouse for ICA1L (see all 11)
    OriGene ORF clones in mouse, rat for ICA1L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ICA1L (NM_138468)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICA1L
    Primer
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    OriGene qPCR primer pairs and template standards for ICA1L
    OriGene qSTAR qPCR primer pairs in human, mouse for ICA1L
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ICA1L
      QuantiTect SYBR Green Assays in human, mouse, rat ICA1L
      QuantiFast Probe-based Assays in human, mouse, rat ICA1L

    Additional mRNA sequence: 

    AB053316.1 AB053317.1 AK055978.1 AK092310.1 AK124756.1 AL833904.1 BC000993.2 BC063876.1 
    BC093902.1 BC112235.1 

    17 DOTS entries:

    DT.91940439  DT.99937523  DT.99939323  DT.91982887  DT.40124826  DT.306976  DT.40275653  DT.121003209 
    DT.121003238  DT.306978  DT.433040  DT.121003220  DT.121003240  DT.40276650  DT.40293648  DT.91982888 
    DT.91979443 

    Selected AceView cDNA sequences (see all 66):

    BC000993 CD244054 NM_138468 AU186027 M78317 AX747473 BU689994 BC063876 
    AK092310 AA324506 CA447283 AL833904 BX279983 AA774047 AK055978 AK124756 
    BQ549302 CK819608 BE540319 AI282592 BM129642 BM129358 AI334623 BQ581123 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ICA1L    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                                              -           -                                                   
    SP2:                                                              -                                                               
    SP3:              -                                                                                                               
    SP4:                          -     -                                                                                             
    SP5:                                                                          -                                                   


    ECgene alternative splicing isoforms for ICA1L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ICA1L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTCTATCT
    ICA1L Expression
    About this image

    ICA1L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ICA1L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516629
        Custom PCR Arrays for ICA1L
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICA1L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ICA1L gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ica1l1 , 5 islet cell autoantigen 1-like1, 5 84.42(n)1
    82.24(a)1
      1 (30.45 cM)5
    703751  NM_027407.31  NP_081683.31 
     599890705 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.174312 Danio rerio mRNA similar to islet cell autoantigen more 75.31(n)    BC044404.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG105661 CG10566 51.64(n)
    47.54(a)
      40331  NM_001259926.1  NP_001246855.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ric-196
    Protein RIC-19 (ric-19) mRNA, complete cds
    30(a)
    1 → many
    I(3778090-3781658) WBGene00004368


    ENSEMBL Gene Tree for ICA1L (if available)
    TreeFam Gene Tree for ICA1L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ICA1L gene
    ICA12  
    3 SIMAP similar genes for ICA1L using alignment to 15 protein entries:     ICA1L_HUMAN (see all proteins):
    ALS2CR14    ICAp69    ICA1

    Find genes that share paralogs with ICA1L           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ICA1L (see all 1630)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1163081311,2
    F--203637414(+) GCAATC/AGCGGC 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1512459521,2
    --203637415(+) CAATCA/GCGGCT 1 -- ds50010--------
    rs1131118551,2
    C--203637417(+) ATCGCA/GGCTCA 1 -- ds50011Minor allele frequency- G:0.00CSA 1
    rs1423141431,2
    --203637523(+) TTGTAC/TTTTTA 1 -- ds50010--------
    rs1461110391,2
    --203637656(+) ATTGGG/TTTTTA 1 -- ds50010--------
    rs1388933951,2
    C--203637769(+) AAAATA/GTGTTA 1 -- ds50010--------
    rs1157394231,2
    C,F--203637779(+) AGTAGT/CGGTTA 1 -- ds50011Minor allele frequency- C:0.13WA 118
    rs1894457361,2
    --203637872(+) TTTTTA/TAAATT 1 -- ds50010--------
    rs75979591,2
    C,F,A,H--203637873(+) TTTTTA/TAATTT 1 -- ut318Minor allele frequency- T:0.42NA CSA WA EA 372
    rs1808267651,2
    --203637933(+) CAAAGA/GAATGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ICA1L (203637873 - 203736708 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ICA1L:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv875715CNV Loss21882294
    nsv470510CNV Gain18288195
    nsv460020CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ICA1L
    DNA2.0 Custom Variant and Variant Library Synthesis for ICA1L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for ICA1L:    
    About MalaCards
    lateral sclerosis    amyotrophic lateral sclerosis


    Find genes that share disorders with ICA1L           About GenesLikeMe

    Genetic Association Database (GAD): ICA1L
    Human Genome Epidemiology (HuGE) Navigator: ICA1L (1 document)

    Export disorders for ICA1L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ICA1L gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ICA1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. (PubMed id 11586298)1, 2, 3 Hadano S....Ikeda J.-E. (Nat. Genet. 2001)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 130026 HGNC: 14442 AceView: ALS2CR15 Ensembl:ENSG00000163596 euGenes: HUgn130026
    ECgene: ICA1L H-InvDB: ICA1L

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ICA1L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ICA1L gene:
    Search GeneIP for patents involving ICA1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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