ICA1L Gene
protein-coding GIFtS: 46
GCID: GC02M203639
|
|
islet cell autoantigen 1,69kDa-like(Previous names: amyotrophic lateral sclerosis 2 (juvenile) chromosome region,...)
(Previous symbols: ALS2CR15, ALS2CR14)
| |
Aliases
for ICA1L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Islet Cell Autoantigen 1,69kDa-Like1 2 | | Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 14 Protein2 3 | | ALS2CR141 2 3 | | Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 15 Protein2 3 | | ALS2CR151 2 3 | | Ica69-Related Protein2 | | Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 141 2 | | Islet Cell Autoantigen 1-Like Protein2 | | Amyotrophic Lateral Sclerosis 2 (Juvenile) Chromosome Region, Candidate 151 2 | | |
Export aliases for ICA1L gene to outside databasesPrevious GC identifers: GC02M203350 GC02M195484 |
Summaries
for ICA1L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ICA1L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ICA1L gene promoter:
SRF SRF (504 AA) POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ICA1L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ICA1L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q33.2 Ensembl cytogenetic band: 2q33.2 HGNC cytogenetic band: 2q33ICA1L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M203639: view genomic region
(about GC identifiers)
Start:
|
203,637,873 bp from pter |
End:
|
203,736,708 bp from pter |
Size:
|
98,836 bases |
Orientation:
|
minus strand |
|
Proteins
for ICA1L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ICA1L_HUMAN, Q8NDH6 (See
protein sequence)Recommended Name: Islet cell autoantigen 1-like protein Size: 482 amino acids; 54407 Da
Secondary accessions: B3KRW6 Q53P45 Q53QZ4 Q53T97 Q96N47 Q96Q32 Q9BVQ2Alternative splicing: 2 isoforms: Q8NDH6-1 Q8NDH6-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ICA1L: NX_Q8NDH6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NDH6
ICA1L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_612477.3 NP_839945.1
ENSEMBL proteins: ENSP00000376070 ENSP00000351047 ENSP00000398916 ENSP00000400249 ENSP00000404189 ENSP00000412158 ENSP00000410747 ENSP00000405592 ENSP00000410135 ENSP00000404618 ENSP00000387382 ENSP00000398420 ENSP00000404707 ENSP00000397827 ENSP00000392609 ENSP00000416726 ENSP00000409741 ENSP00000414916
Human Recombinant Protein Products:
ICA1L Antibody Products:
Assay Products for ICA1L: |
Protein
Domains /
Families
for ICA1L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ICA1L for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NDH6ProtoNet protein and cluster: Q8NDH6 2 Blocks protein families: IPB006723 Islet cell autoantigen ICA69 homologue IPB010504 Arfaptin-like
UniProtKB/Swiss-Prot: ICA1L_HUMAN, Q8NDH6Similarity: Contains 1 AH domain |
Function
for ICA1L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ICA1L (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ICA1L (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ICA1L (NM_138468) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ICA1L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICA1L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICA1L |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019904 | protein domain specific binding |
IEA | -- |
ICA1L for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for ICA1L:
|
Pathways & Interactions
for ICA1L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ICA1L
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
4 Interacting proteins for ICA1L (Q8NDH63 ENSP000003510474) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ICA1L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ICA1L
Search CenterWatch for drugs/clinical trials and news about ICA1L
|
Transcripts
for ICA1L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ICA1L gene (2 alternative transcripts): NM_138468.4 NM_178231.2 Unigene Cluster for ICA1L: Islet cell autoantigen 1,69kDa-like Hs.516629 [show with all ESTs]Unigene Representative Sequence: NM_13846818/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21): ENST00000392237(uc002uzh.1 uc002uzi.1 uc021vvi.1) ENST00000358299
ENST00000438804 ENST00000420558 ENST00000494560 ENST00000476602 ENST00000425178(uc002uzj.3)
ENST00000418208 ENST00000450143 ENST00000435143 ENST00000419460 ENST00000441547
ENST00000412210 ENST00000437978 ENST00000457524 ENST00000432273 ENST00000416760
ENST00000454326
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ICA1L (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ICA1L (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ICA1L (NM_138468) | | | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AB053316.1 AB053317.1 AK055978.1 AK092310.1 AK124756.1 AL833904.1 BC000993.2 BC063876.1 BC093902.1 BC112235.1 17 DOTS entries: DT.91940439 DT.99937523 DT.99939323 DT.91982887 DT.40124826 DT.306976 DT.40275653 DT.121003209 DT.121003238 DT.306978 DT.433040 DT.121003220 DT.121003240 DT.40276650 DT.40293648 DT.91982888 DT.91979443 24/66 AceView cDNA sequences (see all 66): AX747473 AU186027 CD244054 AK092310 AA324506 BC063876 CA447283 AL833904 BU689994 NM_138468 M78317 AA774047 BX279983 BC000993 BE540319 BF793908 BM129642 BM129358 BQ549302 BU753318 BP369364 AI298642 BF378039 BM565108
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ICA1L About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ICA1L
|
Expression
for ICA1L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ICA1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTCTATCT
About this image
See ICA1L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ICA1L
SOURCE GeneReport for Unigene cluster: Hs.516629
SABiosciences Custom PCR Arrays for ICA1L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ICA1L
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICA1L |
Orthologs
for ICA1L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ICA1L gene from 4/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Ica1l1 , 5 |
islet cell autoantigen 1-like1, 5 |
83.57(n)1
81.63(a)1 |
|
1 (30.45 cM)5
703751 NM_027407.31 NP_081683.31
599890705 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.174312 |
Danio rerio mRNA similar to islet cell autoantigen more |
75.31(n) |
|
BC044404.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG105666 |
-- |
35(a) |
1 → many |
3L(21124546-21126410) |
worm
(Caenorhabditis elegans) |
Secernentea |
ric-196 |
Resistance to inhibitors of cholinesterase protein... |
30(a) |
1 → many |
I(3778093-3781661) |
ENSEMBL Gene Tree for ICA1L (if available)
TreeFam Gene Tree for ICA1L (if available) |
Paralogs
for ICA1L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ICA1L gene
- ICA12
3 SIMAP similar genes for ICA1L using alignment to 15 protein entries: ICA1L_HUMAN (see all proteins):ALS2CR14 ICAp69 ICA1
ICA1L for paralogs About GeneDecksing
|
Genomic Variants
for ICA1L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ICA1L (203637873 - 203736708 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ICA1L: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ICA1L |
|
Disorders
/ Diseases
for ICA1L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ICA1L for disorders About GeneDecksing
2  diseases for ICA1L: About MalaCardsamyotrophic lateral sclerosis lateral sclerosis
Human Genome Epidemiology (HuGE) Navigator: ICA1L (1 document)
Export disorders for ICA1L gene to outside databases
|
Publications
for ICA1L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ICA1L gene integrated from 9 sources:
(articles sorted by number of sources associating them with ICA1L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. (PubMed id 11586298)1, 2, 3 Hadano S....Ikeda J.-E. (2001)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ICA1L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ICA1L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ICA1L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ICA1L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ICA1L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ICA1L gene:
Search GeneIP for patents involving ICA1L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ICA1L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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