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ICA1 Gene

protein-coding GIFtS: 62

GC07M008119

islet cell autoantigen 1, 69kDa
(Previous name: islet cell autoantigen 1 (69kD) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ICA69 ^², ³
ICAp69 ^¹, ², ³
p69 ^³

Descriptions
69 kDa islet cell autoantigen ^³
Islet cell autoantigen p69 ^², ³
diabetes mellitus type I autoantigen ^²
islet cell autoantigen 1 ^²
islet cell autoantigen 1 (69kD) ^¹, ²
islet cell autoantigen 1 isoform ^²
islet cell autoantigen 1, 69kDa ^²

External Ids
HGNC: 5343¹
Entrez Gene: 3382²
UniProtKB: Q05084³
Ensembl: ENSG00000003147⁷

Search outside databases for aliases for ICA1 gene

Previous GC identifers: GC07M007797 GC07M007897 GC07M007926

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for ICA1:

This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and

as membrane-bound form on the Golgi complex and immature secretory granules. This protein is

believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's

syndrome. Alternatively spliced variants which encode different protein isoforms have been

described; however, not all variants have been fully characterized. [provided by RefSeq]

UniProtKB/Swiss-Prot: ICA69_HUMAN, Q05084

Function: May play a role in neurotransmitter secretion (By similarity)

Gene Wiki entry for ICA1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ICA1 gene

Entrez Gene cytogenetic band: 7p22 Ensembl cytogenetic band: 7p21.3 HGNC cytogenetic band: 7p22

ICA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M008119: (about GC identifiers)

Start:	8,119,339 bp from pter
End:	8,268,767 bp from pter
Size:	149,429 bases
Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 8,198,979-8,348,327

RefSeq DNA sequence:

NC_000007.12 NT_007819.16 NT_079592.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ICA69_HUMAN, Q05084 (See protein sequence)

Recommended Name: Islet cell autoantigen 1

Size: 483 amino acids; 54645 Da

Subcellular location: Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein

(Potential). Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein

(Potential). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral

membrane protein (Potential). Note=Predominantly cytosolic. Also exists as a membrane-bound form

which has been found associated with synaptic vesicles and also with the Golgi complex and

immature secretory granules

Secondary accessions: P78506 Q13824

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001129492.1 NP_004959.2 NP_071682.1

ENSEMBL proteins:

ENSP00000386021 ENSP00000316074 ENSP00000385651 ENSP00000265577 ENSP00000341603 ENSP00000385125

ENSP00000385305 ENSP00000385570 ENSP00000379908

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ICA1)
	Human Recombinant Proteins from Abnova (ICA1)

OriGene Purified Recombinant Human Proteins (see all 2): ICA1

5/10 Gene Ontology (GO) cellular component terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IDA	12682071
GO:0005737	cytoplasm	TAS	8326004
GO:0005794	Golgi apparatus	IEA	--
GO:0005829	cytosol	ISS	--
GO:0016020	membrane	IEA	--

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Antibodies for ICA1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ICA1
	R&D Systems Antibodies for ICA1
	Antibodies from Abcam (ICA1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ICA1)
	Novus Biologicals Antibodies for ICA1

Assays for ICA1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q05084

ProtoNet protein and cluster: Q05084

2 Blocks protein families:

IPB006723 Islet cell autoantigen ICA69 homologue

IPB010504 Arfaptin-like

UniProtKB/Swiss-Prot: ICA69_HUMAN, Q05084

Similarity: Contains 1 AH domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ICA1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ICA1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001136020

Applied Biosystems Silencer® siRNAs for ICA1

Sigma-Aldrich siRNA for ICA1

Sigma-Aldrich shRNA for ICA1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ICA1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001136020
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001136020
untagged cDNA clones in CMV expression vector (see all 4): NM_001136020

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001136020

UniProtKB/Swiss-Prot: ICA69_HUMAN, Q05084

Function: May play a role in neurotransmitter secretion (By similarity)

Genatlas biochemistry entry for ICA1:

islet cell antigen 1,encoding p69 protein,candidate autoimmune target in insulin dependent diabetes

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ica1):

homeostasis/metabolism

immune system

life span-post-weaning/aging

normal

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0005515	protein binding	IPI	17353931

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for ICA1 (Your Favorite Gene powered by Ingenuity)

Type I Diabetes Mellitus Signaling

GeneDecks ICA1 for the pathways selected above

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5/9 Interacting proteins for ICA1 (Q05084¹ ENSP00000265577³) via UniProtKB, MINT, and/or STRING (see all 9 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CNTF	P26441¹	EBI-1046751, EBI-1050897
KRT33B	Q14525¹	EBI-1046751, EBI-1049638
STK16	O75716¹	EBI-1046751, EBI-1046308
MKKS	Q9HB66¹	EBI-1046751, EBI-1054754
GAD2	ENSP00000259271³	STRING (score=.909)

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006836	neurotransmitter transport	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ICA1
1 Novoseek chemical compound relationship for ICA1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	0.00	2	9054945 (1), 10886245 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ICA1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ICA1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001136020

Sigma-Aldrich siRNA for ICA1

Sigma-Aldrich shRNA for ICA1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001136020 NM_004968 NM_022307

REFSEQ mRNAs for ICA1 gene (3 alternative transcripts):

NM_001136020.1 NM_004968.2 NM_022307.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001136020 NM_004968 NM_022307

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001136020
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001136020
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001136020

Additional cDNA sequence:

AK292106.1 BC008640.2 CR601104.1 CR605198.1 CR620744.1 CR624499.1 EU416199.1 L01100.1

L21181.1 U26591.1 U37183.1

18 DOTS entries:

DT.95181863 DT.452369 DT.100687709 DT.95181856 DT.86851562 DT.121092340 DT.100767508 DT.100013159

DT.95181866 DT.87015565 DT.100836789 DT.121092330 DT.121092353 DT.75102828 DT.95181855 DT.95181865

DT.120658835 DT.97858648

24/153 AceView cDNA sequences (see all 153 ):

BU070273 CR601104 AI285041 AA421512 AA482169 BX331325 U37183 CR624499

BM853042 BG776267 BM853686 BE736046 BC008640 BX354959 CR605198 BX464865

CB178778 CB134411 AI654123 AI720028 BE549769 AA916921 BU681497 CR620744

highest scoring ESTs for ICA1:

AL517028 BC008640 BF240155 BI830528 CK141543 L01100 U26591 U38260 AA482169 AA491302

Unigene Cluster for ICA1:

Islet cell autoantigen 1, 69kDa

Hs.487561 [show with all ESTs]

Unigene Representative Sequence: NM_004968

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ICA1

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	·	16c
SP1:							-										-
SP2:							-										-
SP3:							-										-								-		-		-		-		-
SP4:									-		-		-		-		-		-		-		-		-		-		-		-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for ICA1

9 Ensembl transcripts including schematic representations:

ENST00000407906 ENST00000317367 ENST00000406470 ENST00000265577 ENST00000339809 ENST00000404556

ENST00000401396 ENST00000402384 ENST00000396675

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ICA1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ICA1

¹ / ² / ³

10 probe-sets matching ICA1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32633_at²^{, 3}	U95-A	1	1.00	1.00	0.96	0.97	U26591	0.80	1.00	0.91	1
32634_s_at²^{, 3}	U95-A	2	1.00	0.97	0.89	1.03	U38260	0.80	1.00	0.91	1
210547_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	L21181	0.60	1.00	0.82	1
207949_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004968	0.60	1.00	0.82	1
211740_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC005922	0.40	1.00	0.76	1
204002_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_022307	0.60	1.00	0.82	1
210547_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207949_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211740_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204002_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ICA1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCGCCCCCAG

SOURCE GeneReport for Unigene cluster: Hs.487561
Expression variation in blood from EXPOLDB for ICA1
UniProtKB/Swiss-Prot: ICA69_HUMAN, Q05084
Tissue specificity: Expressed abundantly in pancreas, heart and brain with low levels of expression
in lung, kidney, liver and thyroid

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ICA1 gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ICA1¹	--	islet cell autoantigen 1, 69kDa	92.43(n) 94.37(a)	475242 XM_532475.2 XP_532475.1
chimpanzee (Pan troglodytes)	ICA1¹	--	islet cell autoantigen 1, 69kDa	99.31(n) 99.38(a)	463264 XM_518971.2 XP_518971.2
cow (Bos taurus)	ICA1¹	--	islet cell autoantigen 1, 69kDa	90.62(n) 92.08(a)	535346 NM_001038168.1 NP_001033257.1
rat (Rattus norvegicus)	Ica1¹	--	islet cell autoantigen 1	87.5(n) 89.58(a)	81024 NM_030844.1 NP_110471.1
mouse (Mus musculus)	Ica1^{1, 5}	6 (2.90 cM)⁵	islet cell autoantigen 1^{1, 5}	86.96(n)¹ 89.75(a)¹	15893¹ NM_010492.2¹ NP_034622.2¹ AA008044⁵ AB303567⁵ (see all 31)

About this table Species with no ortholog for ICA1

ENSEMBL Gene Tree for ICA1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ICA1 gene

ICA1L²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/924 NCBI SNPs in ICA1 are shown (see all 924 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 356)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1057947^1,2	A,C,F,H	8119504(-)	`CTTCTC/GTCCAA`	2	--	ut3¹		11		MN EA NA EU WA	974
--	rs9472^1,2	A,C,F,H	8268809(+)	`CCAGGG/ATTCCC`	2	--	ng3¹		9		MN EA EU WA	2630
	rs3757510^1,2	C,F,H	8269175(-)	`ACATAG/CATAAT`	2	--	ng3¹		7		EA MN EU WA	2246
	rs12702698^1,2	A,F,H	8118865(+)	`TGGCCT/CCAGGA`	2	--	ng5¹		4		EU EA WA	390
	rs3757509^1,2	C,F,H	8269934(-)	`ATCTTC/TCTTTT`	2	--	ng3¹ trp³		4		EU EA WA	420
	rs7791232^1,2	A,H	8119099(+)	`TAATAG/CTGGCA`	2	--	ng5¹		4		EU EA WA	420
--	rs3735455^1,2	C	8119512(-)	`GAGCTA/GGGCTT`	2	--	ut3¹		0	--	--	--	--
	rs3807868^1,2	H	8270078(-)	`ATTTAC/TCGGGC`	2	--	ng3¹		4		EU EA WA	418
	rs7798010^1,2	A,C,F,H	8164751(+)	`TGACAA/CACATC`	3	V/V	syn¹		2		EU NA	196
	rs7802005^1,2	C,F,H	8164805(+)	`GTTTGT/CACCTA`	3	V/V	syn¹		5		EU EA WA NA	484

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HapMap Linkage Disequilibrium images for ICA1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 147625

UniProtKB/Swiss-Prot: ICA69_HUMAN, Q05084

Identified as an autoantigen in insulin-dependent diabetes mellitus

7 Novoseek disease relationships for ICA1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
diabetes mellitus insulin-dependent	67.65	4	9054945 (1), 10433084 (1), 8975715 (1), 8777998 (1)
autoimmunity	64.25	5	8975715 (1), 9073547 (1), 10433097 (1), 8777998 (1) (see all 5)
insulinoma	56.48	1	12682071 (1)
pancreas exocrine	54.16	2	9028728 (1), 8777998 (1)
mimicry	45.57	4	9313748 (3)
rheumatoid arthritis	29.19	5	7758883 (2), 10433084 (2), 8647206 (1)
autoimmune diseases	25.83	1	9054945 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/41 PubMed articles for ICA1 gene (see all 41 ):

Cloning of human and rat p69 cDNA, a candidate autoimmune target in type 1 diabetes. (PubMed id 7918678)^{1, 2, 3, 4} Miyazaki I.... Dosch H.-M. (1994)
ICA69 is expressed equally in the human endocrine and exocrine pancreas. (PubMed id 8777998)^{1, 2, 3} Mally M.I....Otonkoski T. (1996)
Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells. (PubMed id 12682071)^{1, 3, 4} Spitzenberger F.... Solimena M. (2003)
Genomic organization and transcript analysis of ICAp69, a target antigen in diabetic autoimmunity. (PubMed id 8975715)^{1, 3, 4} Gaedigk R.... Dosch H.-M. (1996)
Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen. (PubMed id 8326004)^{3, 4} Pietropaolo M.... Eisenbarth G.S. (1993)
Alternative core promoters regulate tissue-specific transcription from the autoimmune diabetes-related ICA1 (ICA69) gene locus. (PubMed id 12409289)^{1, 3} Friday R.P....Pietropaolo M. (2003)
Autoantibodies to the islet antigen ICA69 occur in IDDM and in rheumatoid arthritis. (PubMed id 7758883)^{1, 3} Martin S....Pfutzner A. (1995)
Gene expression of islet cell antigen p69 in human, mouse, and rat. (PubMed id 8603775)^{1, 3} Karges W....Dosch H.M. (1996)
T cell activation and anergy to islet cell antigen in type I diabetes. (PubMed id 7822811)^{1, 3} Miyazaki I.... Dosch H.M. (1995)
ICA1 encoding p69, a protein linked to the development of type 1 diabetes, maps to human chromosome 7p22. (PubMed id 8162706)^{1, 3} Gaedigk R.... Dosch H.M. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 3382	HGNC: 5343	AceView: ICA1	Ensembl:ENSG00000003147	euGenes: HUgn3382
ECgene: ICA1	H-InvDB: ICA1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ICA1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ICA1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ICA1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ICA1		Antibodies for ICA1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ICA1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ICA1)
	Antibodies (ICA1)
	Chimera RNAi (ICA1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (ICA1)
	Antibodies (ICA1)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

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Antibodies for ICA1

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ICA1 Gene at Home site.
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ICA1 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for ICA1

Summaries
for ICA1

Genomic Location
for ICA1

Proteins
for ICA1

Protein Domains/
Families
for ICA1

Gene Function
for ICA1

Pathways & Interactions
for ICA1

Drugs & Compounds
for ICA1

Transcripts
for ICA1

Expression
for ICA1

Orthologs
for ICA1

Paralogs
for ICA1

SNPs/Variants
for ICA1

Disorders & Mutations
for ICA1

Medical News
for ICA1

Publications
for ICA1

Search for ICA1

Genome Databases showing ICA1

Other Databases showing ICA1

Specialized Databases showing ICA1

Licensable Technologies
for ICA1

Services
for ICA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ICA1 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor ICA1

Summariesfor ICA1

Genomic Locationfor ICA1

Proteinsfor ICA1

Protein Domains/Familiesfor ICA1

Gene Functionfor ICA1

Pathways & Interactionsfor ICA1

Drugs & Compoundsfor ICA1

Transcriptsfor ICA1

Expression for ICA1

Orthologsfor ICA1

Paralogsfor ICA1

SNPs/Variantsfor ICA1

Disorders & Mutationsfor ICA1

Medical Newsfor ICA1

Publicationsfor ICA1

Search for ICA1

Genome Databases showing ICA1

Other Databases showing ICA1

Specialized Databases showing ICA1

Licensable Technologiesfor ICA1

Servicesfor ICA1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ICA1

Summaries
for ICA1

Genomic Location
for ICA1

Proteins
for ICA1

Protein Domains/
Families
for ICA1

Gene Function
for ICA1

Pathways & Interactions
for ICA1

Drugs & Compounds
for ICA1

Transcripts
for ICA1

Expression
for ICA1

Orthologs
for ICA1

Paralogs
for ICA1

SNPs/Variants
for ICA1

Disorders & Mutations
for ICA1

Medical News
for ICA1

Publications
for ICA1

Licensable Technologies
for ICA1

Services
for ICA1