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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ICA1 Gene

protein-coding   GIFtS: 60
GCID: GC07M008119

Islet Cell Autoantigen 1, 69kDa

(Previous name: islet cell autoantigen 1 (69kD))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Islet Cell Autoantigen 1, 69kDa1 2     p692 3
Islet Cell Autoantigen P692 3     Islet Cell Autoantigen 1 (69kD)1
69 KDa Islet Cell Autoantigen2 3     Diabetes Mellitus Type I Autoantigen2
ICA692 3     Islet Cell Autoantigen 12
ICAp692 3     Islet Cell Autoantigen 1 Isoform2

External Ids:    HGNC: 53431   Entrez Gene: 33822   Ensembl: ENSG000000031477   OMIM: 1476255   UniProtKB: Q050843   

Export aliases for ICA1 gene to outside databases

Previous GC identifers: GC07M007797 GC07M007897 GC07M007926 GC07M008002


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ICA1 Gene:
This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as
membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an
autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants
encoding two different isoforms have been found for this gene. (provided by RefSeq, Feb 2013)

GeneCards Summary for ICA1 Gene: 
ICA1 (islet cell autoantigen 1, 69kDa) is a protein-coding gene. Diseases associated with ICA1 include diabetes mellitus, and sjogren's syndrome, and among its related super-pathways are Allograft rejection. GO annotations related to this gene include molecular_function and protein domain specific binding. An important paralog of this gene is ICA1L.

UniProtKB/Swiss-Prot: ICA69_HUMAN, Q05084
Function: May play a role in neurotransmitter secretion (By similarity)

Gene Wiki entry for ICA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ICA1 gene promoter:
         Nkx6-1   NF-kappaB   NF-E2   NF-E2 p45   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ICA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ICA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ICA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22   Ensembl cytogenetic band:  7p21.3   HGNC cytogenetic band: 7p22

ICA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ICA1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M008119:  view genomic region     (about GC identifiers)

Start:
8,152,814 bp from pter      End:
8,302,317 bp from pter
Size:
149,504 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 8,198,979-8,348,327     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ICA69_HUMAN, Q05084 (See protein sequence)
Recommended Name: Islet cell autoantigen 1  
Size: 483 amino acids; 54645 Da
Subcellular location: Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein (Potential).
Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein (Potential). Cytoplasmic vesicle,
secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein (Potential). Note=Predominantly
cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also
with the Golgi complex and immature secretory granules
Secondary accessions: A8K7U1 P78506 Q13824

Explore the universe of human proteins at neXtProt for ICA1: NX_Q05084

Explore proteomics data for ICA1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q05084

  • ICA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ICA1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001129492.1  NP_001263407.1  NP_004959.2  NP_071682.1  

    ENSEMBL proteins: 
     ENSP00000385570   ENSP00000265577   ENSP00000379908   ENSP00000410341   ENSP00000341603  
     ENSP00000385305   ENSP00000386021   ENSP00000316074   ENSP00000398435   ENSP00000397496  
     ENSP00000393314   ENSP00000406722   ENSP00000385651   ENSP00000403982  

    Human Recombinant Protein Products for ICA1: 
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    Novus Biologicals ICA1 Protein
    Novus Biologicals ICA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ICA1 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IDA12682071
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol ISS--

    ICA1 for ontologies           About GeneDecksing



    ICA1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR024114 Islet_autoAg_Ica1/Ica1-like
     IPR027267 AH/BAR-dom
     IPR010504 AH_dom
     IPR006723 Islet_autoAg_Ica1_C

    Graphical View of Domain Structure for InterPro Entry Q05084

    ProtoNet protein and cluster: Q05084

    2 Blocks protein domains:
    IPB006723 Islet cell autoantigen ICA69 homologue
    IPB010504 Arfaptin-like


    UniProtKB/Swiss-Prot: ICA69_HUMAN, Q05084
    Similarity: Contains 1 AH domain


    ICA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ICA69_HUMAN, Q05084
    Function: May play a role in neurotransmitter secretion (By similarity)

         Genatlas biochemistry entry for ICA1:
    islet cell antigen 1,encoding p69 protein,candidate autoimmune target in insulin dependent diabetes

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0019904protein domain specific binding IEA--
         
    ICA1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ICA1:
     Decreased POU5F1-GFP protein e  Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ica1):
     homeostasis/metabolism  immune system  mortality/aging  normal 

    ICA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ica1tm1Mdos for ICA1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ICA1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ICA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ICA1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ICA1 

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    hsa-miR-3140-3p hsa-miR-9 hsa-miR-183 hsa-miR-3918
    SwitchGear 3'UTR luciferase reporter plasmidICA1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICA1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ICA1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Allograft rejection
    Type I diabetes mellitus0.69

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for ICA1):
        Type I diabetes mellitus


    ICA1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ICA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/9 Interacting proteins for ICA1 (Q050843 ENSP000003799084) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT33BQ145253, ENSP000002516464I2D: score=2 STRING: ENSP00000251646
    STK16O757163, ENSP000003799644I2D: score=2 STRING: ENSP00000379964
    CNTFP264413, ENSP000003553704I2D: score=2 STRING: ENSP00000355370
    MKKSQ9NPJ13, ENSP000002460624I2D: score=1 STRING: ENSP00000246062
    MYCP011063I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006836neurotransmitter transport IEA--

    ICA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ICA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ICA1 (ICA69)

    2 Novoseek inferred chemical compound relationships for ICA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 35.6 4 9054945 (1), 10886245 (1), 8647206 (1), 8777998 (1)
    tyrosine 0 2 9054945 (1), 10886245 (1)

    Search CenterWatch for drugs/clinical trials and news about ICA1 / ICA69

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ICA1 gene (5 alternative transcripts): 
    NM_001136020.2  NM_001276478.1  NM_004968.3  NM_022307.2  NM_022308.1  

    Unigene Cluster for ICA1:

    Islet cell autoantigen 1, 69kDa
    Hs.487561  [show with all ESTs]
    Unigene Representative Sequence: NM_001136020
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000402384(uc010ktr.3 uc003srm.3 uc003sro.4 uc003srn.4)
    ENST00000265577 ENST00000396675 ENST00000455539 ENST00000339809 ENST00000401396
    ENST00000486677 ENST00000470696 ENST00000407906(uc003srs.1) ENST00000317367
    ENST00000490041 ENST00000447326 ENST00000476942 ENST00000430867 ENST00000457755
    ENST00000446305 ENST00000406470(uc003srq.3 uc003srr.3 uc010kts.3)
    ENST00000422063
    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate ICA1:
    hsa-miR-3140-3p hsa-miR-9 hsa-miR-183 hsa-miR-3918
    SwitchGear 3'UTR luciferase reporter plasmidICA1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK292106.1 BC008640.2 EU416199.1 L01100.1 L21181.1 U26591.1 U37183.1 

    18 DOTS entries:

    DT.95181863  DT.452369  DT.100687709  DT.95181856  DT.86851562  DT.121092340  DT.100013159  DT.100767508 
    DT.95181866  DT.87015565  DT.100836789  DT.121092330  DT.121092353  DT.75102828  DT.95181855  DT.95181865 
    DT.120658835  DT.97858648 

    24/153 AceView cDNA sequences (see all 153):

    BE736046 CR605198 U37183 BX464865 AI554369 CB178778 BM853686 BM853042 
    BE549769 AI654123 AA421512 CR620744 AI720028 BI754058 BX354959 AA482169 
    BC008640 BG776267 CR601104 AI285041 BU681497 BX331325 BU070273 CR624499 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ICA1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
    SP1:                    -                             -                                                                           
    SP2:                    -                             -                                                                           
    SP3:                    -                             -                       -     -     -     -     -                           
    SP4:                          -     -     -     -     -     -     -     -     -     -     -     -     -                           
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for ICA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ICA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGCCCCCAG
    ICA1 Expression
    About this image


    See ICA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ICA1

    SOURCE GeneReport for Unigene cluster: Hs.487561

    UniProtKB/Swiss-Prot: ICA69_HUMAN, Q05084
    Tissue specificity: Expressed abundantly in pancreas, heart and brain with low levels of expression in lung,
    kidney, liver and thyroid

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ICA1 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ica11 , 5 islet cell autoantigen 11, 5 86.68(n)1
    89.96(a)1
      6 (4.38 cM)5
    158931  NM_010492.31  NP_034622.31 
     86305275 
    chicken
    (Gallus gallus)
    Aves ICA11 islet cell autoantigen 1, 69kDa 74.83(n)
    76.36(a)
      420581  XM_418682.2  XP_418682.1 
    lizard
    (Anolis carolinensis)
    Reptilia ICA16
    Uncharacterized protein
    67(a)
    1 ↔ 1
    6(23805972-23873470)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC041225.12   -- 78.33(n)    BC041225.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.196422 Transcribed sequence with moderate similarity to protein more 76.13(n)    57094033 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG105661 , 3 CG105661 50(a)3
    47.24(n)1
    40.2(a)1
      78B23
    403311  NM_141026.21  NP_649283.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ric-191 Protein RIC-19 48.38(n)
    38.06(a)
      191757  NM_058815.3  NP_491216.2 


    ENSEMBL Gene Tree for ICA1 (if available)
    TreeFam Gene Tree for ICA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ICA1 gene
    ICA1L2  
    3 SIMAP similar genes for ICA1 using alignment to 13 protein entries:     ICA69_HUMAN (see all proteins):
    ICAp69    ALS2CR14    ICA1L

    ICA1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ICA1
    PGOHUM00000249015


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3571 SNPs in ICA1 are shown (see all 3571)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1481846761,2
    C--8123785(+) CTGTA-/TGTGTGT 4 -- ds50010--------
    rs2000431401,2
    C--8152318(-) ACACAC/TACACA 4 -- ds50010--------
    rs127026981,2
    C,F,A,H--8152340(+) TGGCCT/CCAGGA 4 -- ds500113Minor allele frequency- C:0.46NS EA NA CSA WA 760
    rs77912321,2
    C,F,A,H--8152574(+) TAATAG/CTGGCA 4 -- ds50014Minor allele frequency- C:0.00NS EA 420
    rs779254551,2
    C,F--8152601(+) CAAATG/ATAAAA 4 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1159909481,2
    C,F--8152607(+) TAAAAC/TTGTGG 4 -- ds50011Minor allele frequency- T:0.01WA 118
    rs747199261,2
    F--8152619(+) TCCCAC/TCCCTG 4 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1157393561,2
    C,F--8152659(+) CCTGCT/CGCTGC 4 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1128852591,2
    C--8152728(+) TCCTT-/CTCCTCTG 4 -- ds50011Minor allele frequency- CTC:0.00CSA 2
    rs624353921,2
    C--8152742(+) CCCACC/TCCCAC 4 -- ds50011Minor allele frequency- T:0.00NA 2

    HapMap Linkage Disequilibrium report for ICA1 (8152814 - 8302317 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for ICA1 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2733941CNV Deletion23290073
    esv2671104CNV Deletion23128226
    nsv5634CNV Insertion18451855
    nsv819085CNV Insertion19587683
    esv2563861CNV Insertion19546169
    esv23629CNV Loss19812545
    nsv528572CNV Loss19592680
    esv2752177CNV Gain17911159
    nsv887492CNV Gain21882294
    nsv464308CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147625    OMIM disorders: --

    8 diseases for ICA1:    About MalaCards
    diabetes mellitus    sjogren's syndrome    insulinoma    vitiligo
    type 1 diabetes    rheumatoid arthritis    arthritis    thyroiditis


    ICA1 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for ICA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diabetes mellitus insulin-dependent 69.2 4 9054945 (1), 10433084 (1), 8975715 (1), 8777998 (1)
    autoimmunity 63.3 5 8975715 (1), 9073547 (1), 10433097 (1), 8777998 (1) (see all 5)
    insulinoma 55.9 1 12682071 (1)
    pancreas exocrine 53.7 2 9028728 (1), 8777998 (1)
    mimicry 44.4 4 9313748 (3)
    rheumatoid arthritis 28 5 7758883 (2), 10433084 (2), 8647206 (1)
    autoimmune diseases 24.5 1 9054945 (1)

    Genetic Association Database (GAD): ICA1
    Human Genome Epidemiology (HuGE) Navigator: ICA1 (4 documents)

    Export disorders for ICA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ICA1 gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with ICA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of human and rat p69 cDNA, a candidate autoimmune target in type 1 diabetes. (PubMed id 7918678)1, 2, 3, 9 Miyazaki I.... Dosch H.-M. (1994)
    2. ICA69 is expressed equally in the human endocrine and exocrine pancreas. (PubMed id 8777998)1, 3, 9 Mally M.I....Otonkoski T. (1996)
    3. Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells. (PubMed id 12682071)1, 2, 9 Spitzenberger F.... Solimena M. (2003)
    4. Genomic organization and transcript analysis of ICAp69, a target antigen in diabetic autoimmunity. (PubMed id 8975715)1, 2, 9 Gaedigk R.... Dosch H.-M. (1996)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Common variants in FOXP1 are associated with generali zed vitiligo. (PubMed id 20526340)1, 4 Jin Y....Spritz R.A. (2010)
    7. A targeted association study in systemic lupus erythe matosus identifies multiple susceptibility alleles. (PubMed id 20962850)1, 4 Budarf M.L....Rioux J.D. (2010)
    8. Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen. (PubMed id 8326004)1, 2 Pietropaolo M.... Eisenbarth G.S. (1993)
    9. Alternative core promoters regulate tissue-specific transcription from the autoimmune diabetes-related ICA1 (ICA69) gene locus. (PubMed id 12409289)1, 9 Friday R.P....Pietropaolo M. (2003)
    10. Autoantibodies to the islet antigen ICA69 occur in IDDM and in rheumatoid arthritis. (PubMed id 7758883)1, 9 Martin S....Pfutzner A. (1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3382 HGNC: 5343 AceView: ICA1 Ensembl:ENSG00000003147 euGenes: HUgn3382
    ECgene: ICA1 Kegg: 3382 H-InvDB: ICA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ICA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ICA1 gene:
    Search GeneIP for patents involving ICA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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