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ICA1 Gene

protein-coding   GIFtS: 60
GCID: GC07M008119

Islet Cell Autoantigen 1, 69kDa

(Previous name: islet cell autoantigen 1 (69kD))
  See ICA1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Islet Cell Autoantigen 1, 69kDa1 2     p692 3
Islet Cell Autoantigen P692 3     Islet Cell Autoantigen 1 (69kD)1
69 KDa Islet Cell Autoantigen2 3     Diabetes Mellitus Type I Autoantigen2
ICA692 3     Islet Cell Autoantigen 12
ICAp692 3     Islet Cell Autoantigen 1 Isoform2

External Ids:    HGNC: 53431   Entrez Gene: 33822   Ensembl: ENSG000000031477   OMIM: 1476255   UniProtKB: Q050843   

Export aliases for ICA1 gene to outside databases

Previous GC identifers: GC07M007797 GC07M007897 GC07M007926 GC07M008002


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ICA1 Gene:
This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as
membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an
autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants
encoding two different isoforms have been found for this gene. (provided by RefSeq, Feb 2013)

GeneCards Summary for ICA1 Gene:
ICA1 (islet cell autoantigen 1, 69kDa) is a protein-coding gene. Diseases associated with ICA1 include diabetes mellitus. GO annotations related to this gene include protein domain specific binding. An important paralog of this gene is ICA1L.

UniProtKB/Swiss-Prot: ICA69_HUMAN, Q05084
Function: May play a role in neurotransmitter secretion (By similarity)

Gene Wiki entry for ICA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ICA1 gene promoter:
         Nkx6-1   NF-kappaB   NF-E2   NF-E2 p45   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ICA1 promoter sequence
   Search Chromatin IP Primers for ICA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ICA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22   Ensembl cytogenetic band:  7p21.3   HGNC cytogenetic band: 7p22

ICA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ICA1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M008119:  view genomic region     (about GC identifiers)

Start:
8,152,814 bp from pter      End:
8,302,317 bp from pter
Size:
149,504 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 8,198,979-8,348,327     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ICA69_HUMAN, Q05084 (See protein sequence)
Recommended Name: Islet cell autoantigen 1  
Size: 483 amino acids; 54645 Da
Secondary accessions: A8K7U1 B3FTQ2 P78506 Q13824
Alternative splicing: 2 isoforms:  Q05084-1   Q05084-2   

Explore the universe of human proteins at neXtProt for ICA1: NX_Q05084

Explore proteomics data for ICA1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ICA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001129492.1  NP_001263407.1  NP_004959.2  NP_071682.1  

    ENSEMBL proteins: 
     ENSP00000385570   ENSP00000265577   ENSP00000379908   ENSP00000410341   ENSP00000341603  
     ENSP00000385305   ENSP00000386021   ENSP00000316074   ENSP00000398435   ENSP00000397496  
     ENSP00000393314   ENSP00000406722   ENSP00000385651   ENSP00000403982  

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    Novus Biologicals ICA1 Protein
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for ICA1

     
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    ICA1 Antibody Products:

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    Search eBioscience for ELISAs for ICA1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR024114 Islet_autoAg_Ica1/Ica1-like
     IPR027267 AH/BAR-dom
     IPR010504 AH_dom
     IPR006723 Islet_autoAg_Ica1_C

    Graphical View of Domain Structure for InterPro Entry Q05084

    ProtoNet protein and cluster: Q05084

    2 Blocks protein domains:
    IPB006723 Islet cell autoantigen ICA69 homologue
    IPB010504 Arfaptin-like


    UniProtKB/Swiss-Prot: ICA69_HUMAN, Q05084
    Similarity: Contains 1 AH domain


    Find genes that share domains with ICA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ICA69_HUMAN, Q05084
    Function: May play a role in neurotransmitter secretion (By similarity)

         Genatlas biochemistry entry for ICA1:
    islet cell antigen 1,encoding p69 protein,candidate autoimmune target in insulin dependent diabetes

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0019904protein domain specific binding IEA--
         
    Find genes that share ontologies with ICA1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ICA1:
     Decreased POU5F1-GFP protein e  Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ica1):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  normal 

    Find genes that share phenotypes with ICA1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ica1tm1Mdos for ICA1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ICA1
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    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate ICA1:
    hsa-miR-3140-3p hsa-miR-9 hsa-miR-183 hsa-miR-3918
    SwitchGear 3'UTR luciferase reporter plasmidICA1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ICA1

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    GenScript: all cDNA clones in your preferred vector (see all 3): ICA1 (NM_022307)
    Sino Biological Human cDNA Clone for ICA1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ICA1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ICA69_HUMAN, Q05084: Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein (Potential).
    Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein (Potential). Cytoplasmic vesicle,
    secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein (Potential). Note=Predominantly
    cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also
    with the Golgi complex and immature secretory granules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    golgi apparatus5
    nucleus4
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IDA12682071
    GO:0005634nucleus ----
    GO:0005737cytoplasm TAS8326004
    GO:0005829cytosol ISS--
    GO:0030054cell junction IEA--

    Find genes that share ontologies with ICA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ICA1 About    
    See pathways by source

    SuperPathContained pathways About
    1Allograft rejection
    Type I diabetes mellitus0.69


    Find genes that share SuperPaths with ICA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for ICA1):
        Type I diabetes mellitus

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ICA1
    Interactions:

        Search GeneGlobe Interaction Network for ICA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ICA1 (Q050843 ENSP000003799084) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT33BQ145253, ENSP000002516464I2D: score=2 STRING: ENSP00000251646
    STK16O757163, ENSP000003799644I2D: score=2 STRING: ENSP00000379964
    CNTFP264413, ENSP000003553704I2D: score=2 STRING: ENSP00000355370
    MKKSQ9NPJ13, ENSP000002460624I2D: score=1 STRING: ENSP00000246062
    MYCP011063I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006836neurotransmitter transport IEA--

    Find genes that share ontologies with ICA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ICA1 (ICA69)

    2 Novoseek inferred chemical compound relationships for ICA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 35.6 4 9054945 (1), 10886245 (1), 8647206 (1), 8777998 (1)
    tyrosine 0 2 9054945 (1), 10886245 (1)



    Find genes that share compounds with ICA1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ICA1 gene (5 alternative transcripts): 
    NM_001136020.2  NM_001276478.1  NM_004968.3  NM_022307.2  NM_022308.1  

    Unigene Cluster for ICA1:

    Islet cell autoantigen 1, 69kDa
    Hs.487561  [show with all ESTs]
    Unigene Representative Sequence: NM_001136020
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000402384(uc010ktr.3 uc003srm.3 uc003sro.4 uc003srn.4)
    ENST00000265577 ENST00000396675 ENST00000455539 ENST00000339809 ENST00000401396
    ENST00000486677 ENST00000470696 ENST00000407906(uc003srs.1) ENST00000317367
    ENST00000490041 ENST00000447326 ENST00000476942 ENST00000430867 ENST00000457755
    ENST00000446305 ENST00000406470(uc003srq.3 uc003srr.3 uc010kts.3)
    ENST00000422063
    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate ICA1:
    hsa-miR-3140-3p hsa-miR-9 hsa-miR-183 hsa-miR-3918
    SwitchGear 3'UTR luciferase reporter plasmidICA1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ICA1
      QuantiFast Probe-based Assays in human, mouse, rat ICA1

    Additional mRNA sequence: 

    AK292106.1 BC008640.2 EU416199.1 L01100.1 L21181.1 U26591.1 U37183.1 

    18 DOTS entries:

    DT.95181863  DT.452369  DT.100687709  DT.95181856  DT.86851562  DT.121092340  DT.100013159  DT.100767508 
    DT.95181866  DT.87015565  DT.100836789  DT.121092330  DT.121092353  DT.75102828  DT.95181855  DT.95181865 
    DT.120658835  DT.97858648 

    Selected AceView cDNA sequences (see all 153):

    BM853686 BM853042 BE549769 AI654123 AA421512 CR620744 AI720028 BI754058 
    BX354959 AA482169 BC008640 BG776267 CR601104 AI285041 BU681497 BX331325 
    BU070273 CR624499 AA916921 CB134411 CB178778 AI554369 BX464865 U37183 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ICA1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
    SP1:                    -                             -                                                                           
    SP2:                    -                             -                                                                           
    SP3:                    -                             -                       -     -     -     -     -                           
    SP4:                          -     -     -     -     -     -     -     -     -     -     -     -     -                           
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for ICA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ICA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGCCCCCAG
    ICA1 Expression
    About this image


    ICA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Epithelial Cells
             Fetal Matrix Cells Hair Follicle
     
     Hair (Integumentary System)
             Fetal Matrix Cells Hair Follicle
     
     Testis (Reproductive System)
    ICA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ICA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.487561

    UniProtKB/Swiss-Prot: ICA69_HUMAN, Q05084
    Tissue specificity: Expressed abundantly in pancreas, heart and brain with low levels of expression in lung,
    kidney, liver and thyroid

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ICA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ICA1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ica11 , 5 islet cell autoantigen 11, 5 86.12(n)1
    88.91(a)1
      6 (4.38 cM)5
    158931  NM_010492.31  NP_034622.31 
     86305275 
    chicken
    (Gallus gallus)
    Aves ICA11 islet cell autoantigen 1, 69kDa 74.83(n)
    76.36(a)
      420581  XM_004939321.1  XP_004939378.1 
    lizard
    (Anolis carolinensis)
    Reptilia ICA16
    islet cell autoantigen 1, 69kDa
    64(a)
    1 ↔ 1
    6(23805972-23873470)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC041225.12   -- 78.33(n)    BC041225.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.196422 Transcribed sequence with moderate similarity to protein more 76.13(n)    57094033 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG105663   -- 50(a)   78B2   --
    worm
    (Caenorhabditis elegans)
    Secernentea ric-196
    Protein RIC-19 (ric-19) mRNA, complete cds
    31(a)
    1 → many
    I(3778090-3781658) WBGene00004368


    ENSEMBL Gene Tree for ICA1 (if available)
    TreeFam Gene Tree for ICA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ICA1 gene
    ICA1L2  
    3 SIMAP similar genes for ICA1 using alignment to 12 protein entries:     ICA69_HUMAN (see all proteins):
    ICAp69    ALS2CR14    ICA1L

    Find genes that share paralogs with ICA1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ICA1
    PGOHUM00000249015


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ICA1 (see all 3571)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1481846761,2
    C--8123785(+) CTGTA-/TGTGTGT 4 -- ds50010--------
    rs2000431401,2
    C--8152318(-) ACACAC/TACACA 4 -- ds50010--------
    rs127026981,2
    C,F,A,H--8152340(+) TGGCCT/CCAGGA 4 -- ds500113Minor allele frequency- C:0.46NS EA NA CSA WA 760
    rs77912321,2
    C,F,A,H--8152574(+) TAATAG/CTGGCA 4 -- ds50014Minor allele frequency- C:0.00NS EA 420
    rs779254551,2
    C,F--8152601(+) CAAATG/ATAAAA 4 -- ds50011Minor allele frequency- A:0.05WA 118
    rs1159909481,2
    C,F--8152607(+) TAAAAC/TTGTGG 4 -- ds50011Minor allele frequency- T:0.01WA 118
    rs747199261,2
    F--8152619(+) TCCCAC/TCCCTG 4 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1157393561,2
    C,F--8152659(+) CCTGCT/CGCTGC 4 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1128852591,2
    C--8152728(+) TCCTT-/CTCCTCTG 4 -- ds50011Minor allele frequency- CTC:0.00CSA 2
    rs624353921,2
    C--8152742(+) CCCACC/TCCCAC 4 -- ds50011Minor allele frequency- T:0.00NA 2

    HapMap Linkage Disequilibrium report for ICA1 (8152814 - 8302317 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ICA1 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2733941CNV Deletion23290073
    esv2671104CNV Deletion23128226
    nsv5634CNV Insertion18451855
    nsv819085CNV Insertion19587683
    esv2563861CNV Insertion19546169
    esv23629CNV Loss19812545
    nsv528572CNV Loss19592680
    esv2752177CNV Gain17911159
    nsv887492CNV Gain21882294
    nsv464308CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ICA1
    DNA2.0 Custom Variant and Variant Library Synthesis for ICA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147625    OMIM disorders: --

    1 disease for ICA1:    
    About MalaCards
    diabetes mellitus


    Find genes that share disorders with ICA1           About GenesLikeMe

    7 Novoseek inferred disease relationships for ICA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diabetes mellitus insulin-dependent 69.2 4 9054945 (1), 10433084 (1), 8975715 (1), 8777998 (1)
    autoimmunity 63.3 5 8975715 (1), 9073547 (1), 10433097 (1), 8777998 (1) (see all 5)
    insulinoma 55.9 1 12682071 (1)
    pancreas exocrine 53.7 2 9028728 (1), 8777998 (1)
    mimicry 44.4 4 9313748 (3)
    rheumatoid arthritis 28 5 7758883 (2), 10433084 (2), 8647206 (1)
    autoimmune diseases 24.5 1 9054945 (1)

    Genetic Association Database (GAD): ICA1
    Human Genome Epidemiology (HuGE) Navigator: ICA1 (4 documents)

    Export disorders for ICA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ICA1 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with ICA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of human and rat p69 cDNA, a candidate autoimmune target in type 1 diabetes. (PubMed id 7918678)1, 2, 3, 9 Miyazaki I.... Dosch H.-M. (Biochim. Biophys. Acta 1994)
    2. ICA69 is expressed equally in the human endocrine and exocrine pancreas. (PubMed id 8777998)1, 3, 9 Mally M.I....Otonkoski T. (Diabetologia 1996)
    3. Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells. (PubMed id 12682071)1, 2, 9 Spitzenberger F.... Solimena M. (J. Biol. Chem. 2003)
    4. Genomic organization and transcript analysis of ICAp69, a target antigen in diabetic autoimmunity. (PubMed id 8975715)1, 2, 9 Gaedigk R.... Dosch H.-M. (Genomics 1996)
    5. A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles. (PubMed id 20962850)1, 4 Budarf M.L....Rioux J.D. (Genes Immun. 2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Common variants in FOXP1 are associated with generalized vitiligo. (PubMed id 20526340)1, 4 Jin Y....Spritz R.A. (Nat. Genet. 2010)
    8. Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen. (PubMed id 8326004)1, 2 Pietropaolo M.... Eisenbarth G.S. (J. Clin. Invest. 1993)
    9. Alternative core promoters regulate tissue-specific transcription from the autoimmune diabetes-related ICA1 (ICA69) gene locus. (PubMed id 12409289)1, 9 Friday R.P....Pietropaolo M. (J. Biol. Chem. 2003)
    10. Autoantibodies to the islet antigen ICA69 occur in IDDM and in rheumatoid arthritis. (PubMed id 7758883)1, 9 Martin S....PfA1tzner A. (Diabetologia 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3382 HGNC: 5343 AceView: ICA1 Ensembl:ENSG00000003147 euGenes: HUgn3382
    ECgene: ICA1 Kegg: 3382 H-InvDB: ICA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ICA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ICA1 gene:
    Search GeneIP for patents involving ICA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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