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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IBTK Gene

protein-coding GIFtS: 57
GCID: GC06M082879

inhibitor of Bruton agammaglobulinemia tyrosine kinase

(Previous name: Bruton agammaglobulinemia tyrosine kinase inhibitor )
(Previous symbol: BTKI)

Explore 2 diseases affiliated with
IBTK via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Inhibitor Of Bruton Agammaglobulinemia Tyrosine Kinase¹ ²		Inhibitor Of Bruton Tyrosine Kinase²
BTKI¹ ² ³		Inhibitor Of Bruton'S Tyrosine Kinase²
BTBD26¹ ²		Inhibitor Of Bruton'S Tyrosine Kinase-Alpha²
Bruton Agammaglobulinemia Tyrosine Kinase Inhibitor¹ ²		Inhibitor Of Bruton'S Tyrosine Kinase-Beta²
DKFZP564B116¹		Inhibitor Of Bruton'S Tyrosine Kinase-Gamma²
RP1-93K22.1²		IBtk³
BTK-Binding Protein²		KIAA1417³

External Ids:	HGNC: 17853¹	Entrez Gene: 25998²	Ensembl: ENSG00000005700⁷	OMIM: 606457⁵	UniProtKB: Q9P2D0³

Export aliases for IBTK gene to outside databases

Previous GC identifers: GC06M082833 GC06M082875 GC06M082936 GC06M080097

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IBTK:

The protein encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In

addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of

nuclear factor-kappa-B-driven transcription. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IBTK_HUMAN, Q9P2D0

Function: Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development.

Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and

NF-kappa-B-driven transcription

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007299.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IBTK gene promoter:
Bach1 AP-1 NF-YA NF-YB Pax-3 CBF-B CBF-A CP1A NF-Y CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IBTK promoter sequence

Search SABiosciences Chromatin IP Primers for IBTK

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IBTK

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14.1 Ensembl cytogenetic band: 6q14.1 HGNC cytogenetic band: 6q14.3

IBTK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IBTK gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M082879: view genomic region (about GC identifiers)

Start:	82,879,700 bp from pter	End:	82,957,471 bp from pter
Size:	77,772 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IBTK_HUMAN, Q9P2D0 (See protein sequence)

Recommended Name: Inhibitor of Bruton tyrosine kinase

Size: 1353 amino acids; 150528 Da

Subunit: Interacts with the PH domain of BTK. Isoform 2 does not interact with BTK

Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane upon

IgM stimulation

Subcellular location: Isoform 2: Nucleus

Sequence caution: Sequence=AAG27170.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=BAA92655.2;

Type=Erroneous initiation; Sequence=CAI23414.1; Type=Erroneous gene model prediction; Sequence=CAI23416.1;

Type=Erroneous gene model prediction;

Secondary accessions: Q2QKU2 Q2QKU3 Q2QKU4 Q5TFD7 Q5TFD9 Q8IUQ9 Q8IUY7 Q8TAI4 Q9HBI8 Q9Y3T8

Alternative splicing: 3 isoforms: Q9P2D0-1 Q9P2D0-2 Q9P2D0-3 (Due to a partial intron retention)

Explore the universe of human proteins at neXtProt for IBTK: NX_Q9P2D0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9P2D0

IBTK Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_056340.2

ENSEMBL proteins:

ENSP00000305721 ENSP00000422136 ENSP00000422762 ENSP00000426405 ENSP00000424634

Human Recombinant Protein Products:

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	Uscn Proteins for IBTK

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	11577348
GO:0016020	membrane	IEA	--

IBTK for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for IBTK

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IBTK for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR009091 Reg_csome_cond/b-lactamase_inh

IPR000210 BTB/POZ-like

IPR002110 Ankyrin_rpt

IPR000408 Reg_chr_condens

IPR011333 BTB/POZ_fold

Graphical View of Domain Structure for InterPro Entry Q9P2D0

ProtoNet protein and cluster: Q9P2D0

2 Blocks protein families:

IPB000210 BTB/POZ domain

IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: IBTK_HUMAN, Q9P2D0

Similarity: Contains 3 ANK repeats

Similarity: Contains 2 BTB (POZ) domains

Similarity: Contains 3 RCC1 repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IBTK_HUMAN, Q9P2D0

Function: Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development.

Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and

NF-kappa-B-driven transcription

miRNA Products:		OriGene 3'-UTR Clone: IBTK Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IBTK
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate IBTK:
		hsa-miR-137 hsa-miR-92a hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-3920 hsa-miR-363 hsa-miR-92b

		SwitchGear 3'UTR luciferase reporter plasmid: IBTK 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IBTK (see all 3) Browse OriGene siRNA
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Gene Editing
Products:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IBTK

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0019901	protein kinase binding	IDA	11577348
GO:0030292	protein tyrosine kinase inhibitor activity	IDA	11577348

IBTK for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for IBTK:

Synthetic lethal with Ras

Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ibtk):

hematopoietic system

immune system

IBTK for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

B cell receptor signaling pathway

BCR signaling pathway

0.41

1 BioSystems Pathway for IBTK

BCR signaling pathway

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IBTK

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/15 Interacting proteins for IBTK (Q9P2D0^{2, 3} ENSP00000305721⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BTK	Q06187²^,³, ENSP00000308176⁴	MINT-49849 MINT-49797 MINT-49799 MINT-49793 I2D: score=5 STRING: ENSP00000308176
EIF4A2	Q14240³, ENSP00000326381⁴	I2D: score=1 STRING: ENSP00000326381
CD2BP2	O95400³, ENSP00000304903⁴	I2D: score=1 STRING: ENSP00000304903
RGS2	P41220³, ENSP00000235382⁴	I2D: score=2 STRING: ENSP00000235382
SNRPN	P63162³	I2D: score=1

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001933	negative regulation of protein phosphorylation	IDA	11577348
GO:0051209	release of sequestered calcium ion into cytosol	IDA	11577348
GO:0061099	negative regulation of protein tyrosine kinase activity	IDA	11577348

IBTK for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IBTK

1 HMDB Compound for IBTK About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about IBTK

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IBTK gene:

NM_015525.2

Unigene Cluster for IBTK:

Inhibitor of Bruton agammaglobulinemia tyrosine kinase

Hs.306425 [show with all ESTs]

Unigene Representative Sequence: DQ005633

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000306270(uc011dyv.1 uc011dyw.1 uc003pjl.1 uc010kbi.1)

ENST00000505222 ENST00000508381 ENST00000445419(uc011dyu.1) ENST00000503400

ENST00000503631 ENST00000510291 ENST00000471036 ENST00000369751(uc003pjm.2)

miRNA Products:		OriGene 3'-UTR Clone: IBTK Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IBTK
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate IBTK:
		hsa-miR-137 hsa-miR-92a hsa-miR-367 hsa-miR-25 hsa-miR-32 hsa-miR-3920 hsa-miR-363 hsa-miR-92b

		SwitchGear 3'UTR luciferase reporter plasmid: IBTK 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: IBTK (NM_015525)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IBTK

Additional cDNA sequence:

AB037838.2 AF235049.1 AJ420588.1 AJ420593.1 AK123460.1 AL050018.1 BC012551.1 BC027483.1

BC027490.1 BC035860.1 BC038244.2 BC042171.1 BC092410.1 BC112929.1 BC113696.1 BC113698.1

BC143736.1 BC143745.1 BC143748.1 DQ005633.1 DQ005634.1 DQ005635.1

9 DOTS entries:

DT.215574 DT.100660747 DT.101964877 DT.100664129 DT.121309204 DT.100027305 DT.101982561 DT.95179878

DT.95179867

24/207 AceView cDNA sequences (see all 207):

BX955988 BM980257 AK123460 AA411705 AA630781 BG680523 AI827319 CB265364

CR600707 CB851543 F02752 AI669354 T50258 BM142101 AK126777 CB266563

AA236615 AI140997 AA007454 BI793295 AA258158 AI277356 CD677578 BU178341

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for IBTK (see all 6) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	·	17c	^	18	^	19	^	20	^	21	^	22	^	23a	·	23b	^
SP1:																																																	-
SP2:
SP3:
SP4:																																	-
SP5:

ExUns:	24	^	25	^	26	^	27	^	28	^	29a	·	29b	^	30
SP1:							-				-
SP2:							-				-
SP3:
SP4:
SP5:											-

ECgene alternative splicing isoforms for IBTK

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IBTK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAAGCAGATG

About this image

IBTK expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See IBTK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IBTK

SOURCE GeneReport for Unigene cluster: Hs.306425

UniProtKB/Swiss-Prot: IBTK_HUMAN, Q9P2D0

Tissue specificity: Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level).

Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietic

tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow). Weakly or not

expressed in other tissues

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IBTK

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IBTK

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for IBTK gene from 7/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	IBTK¹	inhibitor of Bruton agammaglobulinemia tyrosine kinase	74.78(n) 72.98(a)		421844 XM_419865.3 XP_419865.2
lizard (Anolis carolinensis)	Reptilia	IBTK⁶	--	68(a)	1 ↔ 1	1(198163834-198207669)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.16202²	Transcribed sequence with weak similarity to protein more	75.91(n)		BX738761.1
zebrafish (Danio rerio)	Actinopterygii	LOC100535420¹	inhibitor of Bruton tyrosine kinase-like	60.02(n) 60.87(a)		100535420 XM_003200126.1 XP_003200174.1
fruit fly (Drosophila melanogaster)	Insecta	CG8060^{1 , 3}	CG8060¹	29(a)³ 42.35(n)¹ 31.4(a)¹		53B2³ 36824¹ NM_137273.2¹ NP_611117.2¹
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G03790⁶	ankyrin repeat and regulator of chromosome condens...	10(a)	1 ↔ 1	3(961997-968149)
rice (Oryza sativa)	Liliopsida	--	regulator of chromosome condensation/beta-lactamas...	10(a)	1 ↔ 1	7(3490977-3498333)

ENSEMBL Gene Tree for IBTK (if available)
TreeFam Gene Tree for IBTK (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IBTK gene

SERGEF² RCBTB2² WBSCR16² RCBTB1²

4 SIMAP similar genes for IBTK using alignment to 7 protein entries: IBTK_HUMAN (see all proteins):

DKFZp761E1322 MTPN HERC3 RAI14

IBTK for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for IBTK
PGOHUM00000235047

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145156497^1,2		--	82879458(+)	`AATTAC/TATATA`	1	--	ds500¹		0	--	--	--	--
rs147583895^1,2		--	82879507(+)	`CTCTGA/GTTGTA`	1	--	ds500¹		0	--	--	--	--
rs6939291^1,2	C,F,H,	--	82879574(+)	`CCCCAT/CCCAAC`	1	--	ds500¹		10		NS EA CSA WA	1382
rs76690341^1,2		--	82879581(+)	`CAACAA/GAGACC`	1	--	ds500¹		1		EA	120
rs115975637^1,2	F,	--	82879732(+)	`GCAACA/GTCAAT`	1	--	ds500¹		1		WA	118
rs111466095^1,2		--	82880047(+)	`TTTCCG/ATCATT`	1	--	ut3¹		1		CSA	2
rs185074666^1,2		--	82880278(+)	`TATACA/CGTATT`	1	--	ut3¹		0	--	--	--	--
rs144817555^1,2		--	82880405(+)	`ATTTTG/TAAGAT`	1	--	ut3¹		0	--	--	--	--
rs189975435^1,2		--	82880470(+)	`TAAAAC/TGCTAT`	1	--	ut3¹		0	--	--	--	--
rs181159640^1,2		--	82880496(+)	`CTGTTA/CAGAAT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for IBTK (82879700 - 82957471 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for IBTK
3 CNVs: 36572 36571 4499

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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IBTK for disorders           About GeneDecksing

OMIM gene information: 606457    OMIM disorders: --

2 diseases for IBTK:    About MalaCards

agammaglobulinemia bruton-type agammaglobulinemia

Export disorders for IBTK gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for IBTK gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with IBTK)

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Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding protein. (PubMed id 11577348)^{1, 2, 3, 9} Liu W.... Scala G. (2001)
Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk. (PubMed id 18596081)^{1, 2, 9} Spatuzza C....Scala G. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)^{1, 2} Nagase T.... Ohara O. (2000)
Protein phosphatase 1a interacting proteins in the hum an brain. (PubMed id 22321011)¹ Esteves S.L....da Cruz e Silva E.F. (2012)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Btk regulation in human and mouse B cells via protein kinase C phosphorylation of IBtkI^. (PubMed id 21482705)¹ Janda E....Scala G. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 25998	HGNC: 17853	AceView: IBTK	Ensembl:ENSG00000005700	euGenes: HUgn25998
ECgene: IBTK	H-InvDB: IBTK

(According to HUGE)
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HUGE: KIAA1417

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for IBTK	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IBTK gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for IBTK gene:
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GeneCards and IP:
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inhibitor of Bruton agammaglobulinemia tyrosine kinase

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IBTK Gene

inhibitor of Bruton agammaglobulinemia tyrosine kinase

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