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IBTK Gene

protein-coding GIFtS: 56

GC06M082936

inhibitor of Bruton agammaglobulinemia tyrosine kinase
(Previous name: Bruton agammaglobulinemia tyrosine kinase inhibitor )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: BTKI)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BTKI ^², ³
DKFZP564B116 ^¹
IBtk ^³
KIAA1417 ^², ³
MGC142256 ^²
MGC142258 ^²
OTTHUMP00000040002 ^²
RP1-93K22.1 ^²

Descriptions
BTK-binding protein ^²
Bruton agammaglobulinemia tyrosine kinase inhibitor ^¹, ²
inhibitor of Bruton agammaglobulinemia tyrosine kinase ^²
inhibitor of Bruton's tyrosine kinase ^²
inhibitor of Bruton's tyrosine kinase-alpha ^²
inhibitor of Bruton's tyrosine kinase-beta ^²
inhibitor of Bruton's tyrosine kinase-gamma ^²

External Ids
HGNC: 17853¹
Entrez Gene: 25998²
UniProtKB: Q9P2D0³
Ensembl: ENSG00000005700⁷

Search outside databases for aliases for IBTK gene

Previous GC identifers: GC06M082833 GC06M082875

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IBTK:

The protein encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates

BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium

mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven

transcription. [provided by RefSeq]

UniProtKB/Swiss-Prot: IBTK_HUMAN, Q9P2D0

Function: Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell

development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium

mobilization and NF-kappa-B-driven transcription

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IBTK gene

Entrez Gene cytogenetic band: 6q14.1 Ensembl cytogenetic band: 6q14.1 HGNC cytogenetic band: 6q14.3

IBTK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M082936: (about GC identifiers)

Start:	82,936,675 bp from pter
End:	83,014,190 bp from pter
Size:	77,516 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000006.10 NT_007299.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: IBTK_HUMAN, Q9P2D0 (See protein sequence)

Recommended Name: Inhibitor of Bruton tyrosine kinase

Size: 1353 amino acids; 150528 Da

Subunit: Interacts with the PH domain of BTK

Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the

plasma membrane upon IgM stimulation

Sequence caution: Sequence=CAI23414.1; Type=Erroneous gene model prediction; Sequence=CAI23416.1;

Type=Erroneous gene model prediction;

Secondary accessions: Q2QKU2 Q2QKU3 Q2QKU4 Q5TFD7 Q5TFD9 Q8IUQ9 Q8IUY7 Q8TAI4 Q9HBI8 Q9Y3T8

Alternative splicing: 4 isoforms: Q9P2D0-1 Q9P2D0-2 Q9P2D0-3 Q9P2D0-4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_056340.2

ENSEMBL proteins:

ENSP00000305721 ENSP00000358766

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (IBTK)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0016020	membrane	IEA	--

About this table

Antibodies for IBTK:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for IBTK
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Monoclonal and Polyclonal Antibodies from Abnova (IBTK)
	Novus Biologicals Antibodies for IBTK

Assays for IBTK:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9P2D0

ProtoNet protein and cluster: Q9P2D0

2 Blocks protein families:

IPB000210 BTB/POZ domain

IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: IBTK_HUMAN, Q9P2D0

Similarity: Contains 3 ANK repeats

Similarity: Contains 2 BTB (POZ) domains

Similarity: Contains 3 RCC1 repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IBTK)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015525

Applied Biosystems Silencer® siRNAs for IBTK

Sigma-Aldrich siRNA and siRNA Panels for IBTK

Sigma-Aldrich shRNA for IBTK

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_015525
Myc/DDK tagged cDNA clone in CMV expression vector: NM_015525
untagged cDNA clone in CMV expression vector: NM_015525

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_015525

UniProtKB/Swiss-Prot: IBTK_HUMAN, Q9P2D0

Function: Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell

development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium

mobilization and NF-kappa-B-driven transcription

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	11577348 17353931

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for IBTK

5/9 Interacting proteins for IBTK (ENSP00000305721³ Q9P2D0¹) via UniProtKB, MINT, and/or STRING (see all 9 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BTK	Q06187¹	STRING (score=.992) EBI-1521221, EBI-624835
RGS2	P41220¹	EBI-1052017, EBI-712388
SNRPN	P63162¹	EBI-1052017, EBI-712493
BLNK	ENSP00000224337³	STRING (score=.899)
CD79A	ENSP00000221972³	STRING (score=.899)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IBTK

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IBTK)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015525

Sigma-Aldrich siRNA and siRNA Panels for IBTK

Sigma-Aldrich shRNA for IBTK

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_015525

REFSEQ mRNAs for IBTK gene:

NM_015525.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_015525

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015525
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_015525
                                 untagged cDNA clone in CMV expression vector: NM_015525

Additional cDNA sequence:

AB037838.2 AF235049.1 AJ420588.1 AJ420593.1 AK123460.1 AL050018.1 BC012551.1 BC027483.1

BC027490.1 BC035860.1 BC038244.2 BC042171.1 BC092410.1 BC112929.1 BC113696.1 BC113698.1

BC143736.1 BC143745.1 BC143748.1 CR600707.1 DQ005633.1 DQ005634.1 DQ005635.1

9 DOTS entries:

DT.215574 DT.100660747 DT.101964877 DT.100664129 DT.121309204 DT.100027305 DT.95179878 DT.101982561

DT.95179867

24/207 AceView cDNA sequences (see all 207 ):

CA446691 AA428674 T50258 AI128207 AA746291 BM718167 BM142101 CB159281

BG680523 AK123460 AA861452 F02752 CR600707 BQ574422 BI793295 CD677578

BC038244 AL555905 AA258158 AA401255 BC027483 AI827319 CB146286 BC042171

highest scoring ESTs for IBTK:

AI445866 AL050018 BC012551 BF795627 CA407936 AA007318 AA007454 AA194627 AA224232 AA224233

Unigene Cluster for IBTK:

Inhibitor of Bruton agammaglobulinemia tyrosine kinase

Hs.306425 [show with all ESTs]

Unigene Representative Sequence: DQ005633

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for IBTK (see all 6 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	·	17c	^	18	^	19	^	20	^	21	^	22	^	23a	·	23b	^
SP1:																																																	-
SP2:
SP3:
SP4:																																	-
SP5:

ExUns:	24	^	25	^	26	^	27	^	28	^	29a	·	29b	^	30
SP1:							-				-
SP2:							-				-
SP3:
SP4:
SP5:											-

About this scheme

ECgene alternative splicing isoforms for IBTK

2 Ensembl transcripts including schematic representations:

ENST00000306270 ENST00000369751

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IBTK expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IBTK

¹ / ² / ³

6 probe-sets matching IBTK gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
52482_at²^{, 3}	U95-B	1	1.00	1.00	0.93	0.76	AI445866	0.80	1.00	0.91	1
36875_at²^{, 3}	U95-A	1	1.00	1.00	0.65	1.27	AL050018	0.80	1.00	0.91	1
210970_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF235049	0.40	1.00	0.76	1
215086_at²^{, 3}	U133-A	1	0.91	1.00	--	--	AB037838	0.60	0.75	0.68	1
210970_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215086_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

GeneDecks IBTK for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAAGCAGATG

SOURCE GeneReport for Unigene cluster: Hs.306425
Expression variation in blood from EXPOLDB for IBTK
UniProtKB/Swiss-Prot: IBTK_HUMAN, Q9P2D0
Tissue specificity: Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node,
thymus, peripheral blood leukocytes and bone marrow). Weakly or not expressed in other tissues

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IBTK gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IBTK¹	--	inhibitor of Bruton agammaglobulinemia tyrosine kinase	92.5(n) 91.27(a)	481897 XM_539018.2 XP_539018.2
chimpanzee (Pan troglodytes)	IBTK¹	--	inhibitor of Bruton agammaglobulinemia tyrosine kinase	99.66(n) 99.41(a)	462849 XM_001148806.1 XP_001148806.1
cow (Bos taurus)	IBTK¹	--	inhibitor of Bruton agammaglobulinemia tyrosine kinase	92.09(n) 90.53(a)	540885 XM_613576.3 XP_613576.2
mouse (Mus musculus)	Ibtk^{1, 5}	9⁵	inhibitor of Bruton agammaglobulinemia tyrosine kinase^{1, 5}	85.2(n)¹ 86.01(a)¹	108837¹ NM_001081282.1¹ NP_001074751.1¹ AA409502⁵ AK030895⁵ (see all 14)
chicken (Gallus gallus)	IBTK¹	--	inhibitor of Bruton agammaglobulinemia tyrosine kinase	74.78(n) 72.98(a)	421844 XM_419865.2 XP_419865.2

About this table Species with no ortholog for IBTK

ENSEMBL Gene Tree for IBTK

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IBTK gene

SERGEF² RCBTB2² RCBTB1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/393 NCBI SNPs in IBTK are shown (see all 393 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 129)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs991781^1,2	A,C,F,H	82937552(+)	`TACTTT/CACCCC`	1	--	ut3¹		9		NA PA EA MN EU WA	2310
--	rs9449444^1,2	A,C,F,H	82957530(+)	`TGGGGG/ACTTTT`	1	V/A	mis¹		11		EU EA WA NA	980
	rs9294254^1,2	A,C,F,H	83014965(+)	`CAGTAG/AATGAT`	1	--	ng3¹		11		EU EA WA NA	980
	rs487682^1,2	A,F,H	83015911(+)	`tagcaG/Cttagc`	1	--	ng3¹		2		EA	164
	rs6939291^1,2	F,H	82936293(+)	`CCCCAT/CCCAAC`	1	--	ng5¹		4		EU EA WA	396
	rs12662902^1,2	C,H	82961060(+)	`ATTAAC/TATACG`	1	V/I	mis¹		4		EU EA WA	412
--	rs9986531^1,2	H	82967048(+)	`TATTTC/TTTCTT`	1	E/K	mis¹ trp³		4		EU EA WA	406
	rs12193711^1,2	H	82980825(+)	`ATGCAG/AACTTC`	1	F/S	mis¹		4		EU EA WA	420
	rs9986532^1,2	H	82967096(+)	`AATATC/TTGGTC`	1	D/N	mis¹		4		EU EA WA	420
--	rs511636^1,2	A	83015586(+)	`gatcgA/Cgccac`	1	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for IBTK (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 606457

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/12 PubMed articles for IBTK gene (see all 12 ):

Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding protein. (PubMed id 11577348)^{1, 2, 3, 4} Liu W.... Scala G. (2001)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{3, 4} Mungall A.J.... Beck S. (2003)
Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)^{3, 4} Nagase T....Ohara O. (2000)
Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk. (PubMed id 18596081)^{1, 3} Spatuzza C....Scala G. (2008)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)³ Ewing R.M....Figeys D. (2007)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling. (PubMed id 17053785)⁴ Wang Y.... Chen Z. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 25998	HGNC: 17853	AceView: IBTK	Ensembl:ENSG00000005700	euGenes: HUgn25998
ECgene: IBTK	H-InvDB: IBTK

(According to HUGE)
About This Section

HUGE: KIAA1417

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for IBTK
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IBTK:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IBTK-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IBTK		Antibodies for IBTK
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IBTK		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (IBTK)
	Antibodies (IBTK)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Search Tocris compounds for IBTK

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for IBTK

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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IBTK Gene at Home site.
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IBTK Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for IBTK

Summaries
for IBTK

Genomic Location
for IBTK

Proteins
for IBTK

Protein Domains/
Families
for IBTK

Gene Function
for IBTK

Pathways & Interactions
for IBTK

Drugs & Compounds
for IBTK

Transcripts
for IBTK

Expression
for IBTK

Orthologs
for IBTK

Paralogs
for IBTK

SNPs/Variants
for IBTK

Disorders & Mutations
for IBTK

Medical News
for IBTK

Publications
for IBTK

Search for IBTK

Genome Databases showing IBTK

Other Databases showing IBTK

Specialized Databases showing IBTK

Licensable Technologies
for IBTK

Services
for IBTK

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IBTK Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor IBTK

Summariesfor IBTK

Genomic Locationfor IBTK

Proteinsfor IBTK

Protein Domains/Familiesfor IBTK

Gene Functionfor IBTK

Pathways & Interactionsfor IBTK

Drugs & Compoundsfor IBTK

Transcriptsfor IBTK

Expression for IBTK

Orthologsfor IBTK

Paralogsfor IBTK

SNPs/Variantsfor IBTK

Disorders & Mutationsfor IBTK

Medical Newsfor IBTK

Publicationsfor IBTK

Search for IBTK

Genome Databases showing IBTK

Other Databases showing IBTK

Specialized Databases showing IBTK

Licensable Technologiesfor IBTK

Servicesfor IBTK

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IBTK

Summaries
for IBTK

Genomic Location
for IBTK

Proteins
for IBTK

Protein Domains/
Families
for IBTK

Gene Function
for IBTK

Pathways & Interactions
for IBTK

Drugs & Compounds
for IBTK

Transcripts
for IBTK

Expression
for IBTK

Orthologs
for IBTK

Paralogs
for IBTK

SNPs/Variants
for IBTK

Disorders & Mutations
for IBTK

Medical News
for IBTK

Publications
for IBTK

Licensable Technologies
for IBTK

Services
for IBTK