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Aliases for IBSP Gene

Aliases for IBSP Gene

  • Integrin Binding Sialoprotein 2 3
  • Integrin-Binding Sialoprotein 3 4 5
  • Bone Sialoprotein II 2 3 4
  • Cell-Binding Sialoprotein 3 4
  • BSP II 3 4
  • BNSP 3 4
  • Bone Sialoprotein 2
  • BSP-II 3
  • SP-II 3
  • BSP 3

External Ids for IBSP Gene

Previous GeneCards Identifiers for IBSP Gene

  • GC04P088878
  • GC04P089022
  • GC04P089179
  • GC04P089077
  • GC04P088939
  • GC04P088720
  • GC04P084466

Summaries for IBSP Gene

Entrez Gene Summary for IBSP Gene

  • The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for IBSP Gene

IBSP (Integrin Binding Sialoprotein) is a Protein Coding gene. Diseases associated with IBSP include fibrous dysplasia and chondromalacia patellae. Among its related pathways are Degradation of the extracellular matrix and ECM proteoglycans.

UniProtKB/Swiss-Prot for IBSP Gene

  • Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.

Gene Wiki entry for IBSP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IBSP Gene

Genomics for IBSP Gene

Regulatory Elements for IBSP Gene

Genomic Location for IBSP Gene

87,799,550 bp from pter
87,812,449 bp from pter
12,900 bases
Plus strand

Genomic View for IBSP Gene

Genes around IBSP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IBSP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IBSP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IBSP Gene

Proteins for IBSP Gene

  • Protein details for IBSP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bone sialoprotein 2
    Protein Accession:

    Protein attributes for IBSP Gene

    317 amino acids
    Molecular mass:
    35148 Da
    Quaternary structure:
    No Data Available
    • It is possible that the segments of clustered carboxyl groups mediate the strong binding to hydroxyapatite.

neXtProt entry for IBSP Gene

Proteomics data for IBSP Gene at MOPED

Post-translational modifications for IBSP Gene

  • N-glycosylated; glycans consist of sialylated and core-fucosylated bi-, tri- and tetraantennary chains.
  • O-glycosylated at eight sites; mucin-type glycans contain Gal, GlcNAc, GalNAc and terminal NeuAc.
  • Sulfated on either Tyr-313 or Tyr-314.
  • Glycosylation at Asn 104, Thr 119, Thr 122, Asn 177, Asn 182, Asn 190, Thr 227, Thr 228, Thr 229, Thr 238, and Thr 239
  • Modification sites at PhosphoSitePlus

Other Protein References for IBSP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IBSP (IBSP/Sialoprotein II)
  • Cell Signaling Technology (CST) Antibodies for IBSP (Sialoprotein-2)

No data available for DME Specific Peptides for IBSP Gene

Domains & Families for IBSP Gene

Protein Domains for IBSP Gene


Suggested Antigen Peptide Sequences for IBSP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IBSP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for IBSP Gene

Function for IBSP Gene

Molecular function for IBSP Gene

GENATLAS Biochemistry:
sialoprotein,bone (cell adhesion molecule,RGD containing)
UniProtKB/Swiss-Prot Function:
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
genes like me logo Genes that share phenotypes with IBSP: view

Animal Models for IBSP Gene

MGI Knock Outs for IBSP:

Animal Model Products

miRNA for IBSP Gene

miRTarBase miRNAs that target IBSP

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IBSP Gene

Localization for IBSP Gene

Subcellular locations from UniProtKB/Swiss-Prot for IBSP Gene


Subcellular locations from

Jensen Localization Image for IBSP Gene COMPARTMENTS Subcellular localization image for IBSP gene
Compartment Confidence
extracellular 5
cytoskeleton 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IBSP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
genes like me logo Genes that share ontologies with IBSP: view

Pathways & Interactions for IBSP Gene

genes like me logo Genes that share pathways with IBSP: view

Interacting Proteins for IBSP Gene

Gene Ontology (GO) - Biological Process for IBSP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071363 cellular response to growth factor stimulus IEA,ISS --
genes like me logo Genes that share ontologies with IBSP: view

No data available for SIGNOR curated interactions for IBSP Gene

Drugs & Compounds for IBSP Gene

(26) Drugs for IBSP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(41) Additional Compounds for IBSP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IBSP: view

Transcripts for IBSP Gene

mRNA/cDNA for IBSP Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(33) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IBSP Gene

Integrin-binding sialoprotein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IBSP Gene

No ASD Table

Relevant External Links for IBSP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IBSP Gene

mRNA expression in normal human tissues for IBSP Gene

mRNA differential expression in normal tissues according to GTEx for IBSP Gene

This gene is overexpressed in Artery - Coronary (x10.7), Pituitary (x7.2), and Brain - Amygdala (x5.0).

SOURCE GeneReport for Unigene cluster for IBSP Gene Hs.518726

genes like me logo Genes that share expression patterns with IBSP: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IBSP Gene

Orthologs for IBSP Gene

This gene was present in the common ancestor of chordates.

Orthologs for IBSP Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia IBSP 35
  • 81.73 (n)
  • 75.96 (a)
  • 79 (a)
(Mus musculus)
Mammalia Ibsp 35
  • 71.96 (n)
  • 66.35 (a)
Ibsp 16
Ibsp 36
  • 71 (a)
(Pan troglodytes)
Mammalia IBSP 35
  • 98.53 (n)
  • 97.79 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Ibsp 35
  • 70.58 (n)
  • 65.71 (a)
(Bos Taurus)
Mammalia IBSP 36
  • 77 (a)
  • 80.68 (n)
  • 76.49 (a)
(Monodelphis domestica)
Mammalia IBSP 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia IBSP 36
  • 58 (a)
(Gallus gallus)
Aves IBSP 36
  • 41 (a)
(Anolis carolinensis)
Reptilia IBSP 36
  • 41 (a)
Species with no ortholog for IBSP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IBSP Gene

Gene Tree for IBSP (if available)
Gene Tree for IBSP (if available)

Paralogs for IBSP Gene

No data available for Paralogs for IBSP Gene

Variants for IBSP Gene

Sequence variations from dbSNP and Humsavar for IBSP Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs17013182 - 87,811,722(+) CCACC(A/G)CCGTT reference, missense
rs1054628 - 87,811,759(+) GGGCG(C/T)CAATG reference, missense
rs1054627 - 87,811,540(+) CGGAG(A/G)AGACA reference, missense
rs13144371 - 87,811,594(+) AGAAG(A/G)CACCA reference, missense
rs17013181 - 87,811,611(+) CCGGA(A/G)GGCAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for IBSP Gene

Variant ID Type Subtype PubMed ID
nsv515943 CNV Gain+Loss 19592680
dgv322n21 CNV Loss 19592680

Variation tolerance for IBSP Gene

Residual Variation Intolerance Score: 77.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.86; 97.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IBSP Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IBSP Gene

Disorders for IBSP Gene

MalaCards: The human disease database

(9) MalaCards diseases for IBSP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
fibrous dysplasia
  • fibrous dysplasia of bone
chondromalacia patellae
  • chondromalacia of patella
dentin dysplasia
  • dentinal dysplasia
cutaneous anthrax
  • anthrax, skin type
connective tissue disease
  • connective tissue disorder
- elite association - COSMIC cancer census association via MalaCards
Search IBSP in MalaCards View complete list of genes associated with diseases

Relevant External Links for IBSP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IBSP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IBSP Gene

Publications for IBSP Gene

  1. The human bone sialoprotein gene (IBSP): genomic localization and characterization. (PMID: 8406493) Kerr J.M. … Young M.F. (Genomics 1993) 2 3 4 67
  2. Predictive significance of bone sialoprotein and osteopontin for bone metastases in resected Chinese non-small-cell lung cancer patients: a large cohort retrospective study. (PMID: 19376608) Zhang L. … Wang X. (Lung Cancer 2010) 3 23
  3. Bone sialoprotein stimulates focal adhesion-related signaling pathways: role in migration and survival of breast and prostate cancer cells. (PMID: 19492334) Gordon J.A. … Goldberg H.A. (J. Cell. Biochem. 2009) 3 23
  4. Bone sialoprotein does not interact with pro-gelatinase A (MMP-2) or mediate MMP-2 activation. (PMID: 19386107) Hwang Q. … Sodek J. (BMC Cancer 2009) 3 23
  5. Bone sialoprotein and its transcriptional regulatory mechanism. (PMID: 18302613) Ogata Y. (J. Periodont. Res. 2008) 3 23

Products for IBSP Gene

Sources for IBSP Gene

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