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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IBSP Gene

protein-coding   GIFtS: 63
GCID: GC04P088720

integrin-binding sialoprotein
 Explore 51 diseases affiliated with
IBSP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IBSP    

Aliases
for IBSP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Integrin-Binding Sialoprotein1 2 3     Cell-Binding Sialoprotein2 3
BSP1 2     BNSP2 3
BSP-II1 2     BSP II2 3
SP-II1 2     Bone Sialoprotein 22
Bone Sialoprotein II2 3     

External Ids:    HGNC: 53411   Entrez Gene: 33812   Ensembl: ENSG000000295597   OMIM: 1475635   UniProtKB: P218153   

Export aliases for IBSP gene to outside databases

Previous GC identifers: GC04P088878 GC04P089022 GC04P089179 GC04P089077 GC04P088939 GC04P084466


Summaries
for IBSP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IBSP:
The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of
the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic
chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the
trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell
attachment through an RGD sequence that recognizes the vitronectin receptor. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SIAL_HUMAN, P21815
Function: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably
important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment

Gene Wiki entry for IBSP (Bone sialoprotein)


Genomic Views
for IBSP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IBSP gene promoter:
         TBP   AML1a   HOXA3   HSF1 (long)   MEF-2A   SRY   Nkx6-1   HSF1short   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IBSP promoter sequence
   Search SABiosciences Chromatin IP Primers for IBSP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IBSP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.1   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q21.1

IBSP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IBSP gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P088720:  view genomic region     (about GC identifiers)

Start:
 88,720,702 bp from pter      End:
 88,733,601 bp from pter
Size:
 12,900 bases      Orientation:
 plus strand

Proteins
for IBSP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SIAL_HUMAN, P21815 (See protein sequence)
Recommended Name: Bone sialoprotein 2 precursor  
Size: 317 amino acids; 35148 Da
Subcellular location: Secreted
Miscellaneous: It is possible that the segments of clustered carboxyl groups mediate the strong binding to
hydroxyapatite

Explore the universe of human proteins at neXtProt for IBSP: NX_P21815

Post-translational modifications:

  • N-glycosylated; glycans consist of sialylated and core-fucosylated bi-, tri- and tetraantennary chains1
  • O-glycosylated at eight sites; mucin-type glycans contain Gal, GlcNAc, GalNAc and terminal NeuAc1
  • Sulfated on either Tyr-313 or Tyr-3141
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P21815

    • IBSP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004958.2  
    ENSEMBL proteins: 
     ENSP00000226284  
    Reactome Protein details: P21815
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IBSP (IBSP/Sialoprotein II)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: IBSP
    OriGene Custom Protein Services for IBSP 
    GenScript Custom Purified and Recombinant Proteins Services for IBSP
    Novus Biologicals IBSP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IBSP

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space ----
    GO:0031988membrane-bounded vesicle ----


    IBSP for ontologies           About GeneDecksing



    IBSP Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IBSP
    R&D Systems Antibodies for IBSP (IBSP/Sialoprotein II)
    Cell Signaling Technology (CST) Antibodies for IBSP  (sialoprotein 2)
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    OriGene Custom Antibody Services for IBSP 
    GenScript Custom Superior Antibodies Services for IBSP
    Novus Biologicals IBSP Antibody
    Search for Antibodies for IBSP at Abcam  
    Uscn Antibodies for IBSP
    Search ThermoFisher Antibodies for IBSP

    Assay Products for IBSP: 
    Browse Kits and Assays available from EMD Millipore
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    Uscn ELISAs and CLIAs for IBSP

    Protein Domains /
    Families
    for IBSP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IBSP for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR008412 BSP_II

    Graphical View of Domain Structure for InterPro Entry P21815

    ProtoNet protein and cluster: P21815

    1 Blocks protein family: IPB008412 Bone sialoprotein II


    Function
    for IBSP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SIAL_HUMAN, P21815
    Function: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably
    important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment

         Genatlas biochemistry entry for IBSP:
    sialoprotein,bone (cell adhesion molecule,RGD containing)

    miRNA
    Products:            		miRTarBase miRNAs that target IBSP:
    hsa-mir-135b (MIRT003594)

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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IBSP
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate IBSP:
    hsa-miR-4324 hsa-miR-219-1-3p hsa-miR-544b hsa-miR-571 hsa-miR-378* hsa-miR-3667-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IBSP (see all 7)
    OriGene shRNA RFP: IBSP
    OriGene siRNA: IBSP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IBSP

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IBSP

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IBSP (see all 3)
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    GenScript: all cDNA clones in your preferred vector: IBSP (NM_004967)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IBSP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IBSP 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for IBSP
    LifeMap BioReagents: cell lines associated with IBSP: Osteogenic Package 4D20.8,
    Osteogenic Package SK11, Osteogenic Package SM30

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IBSP

    5 GenomeRNAi human phenotypes for IBSP:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased cilium length after  
     Increased Salmonella enterica  

    Animal Models:
         Mouse knock-out Ibsptm1Jeau for IBSP
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ibsp):
     growth/size  limbs/digits/tail  skeleton 

    IBSP for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IBSP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development_Hedgehog and PTH signaling pathways in bone and cartilage development
    		Development_Hedgehog and PTH signaling pathways in bone and cartilage development1.00
    		Development Hedgehog and PTH signaling pathways in bone and cartilage development0.97
    2ECM-receptor interaction
    		ECM-receptor interaction1.00
    		Integrin cell surface interactions0.32
    3Focal Adhesion
    		Focal Adhesion1.00
    		Focal adhesion0.66
    4Cytoskeletal Signaling
    		Cytoskeletal Signaling1.00
    5Adhesion
    		Adhesion1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for IBSP
        Development Hedgehog and PTH signaling pathways in bone and cartilage development


    2 Cell Signaling Technology (CST) Pathways for IBSP
        Cytoskeletal Signaling
    Adhesion

    1 GeneGo (Thomson Reuters) Pathway for IBSP
        Development Hedgehog and PTH signaling pathways in bone and cartilage development

    3 BioSystems Pathways for IBSP 
        Focal Adhesion
    Interleukin-11 Signaling Pathway
    Osteoblast Signaling

    2        Reactome Pathways for IBSP
        Integrin cell surface interactions
    Signal Transduction


    2         Kegg Pathways  (Kegg details for IBSP):
        Focal adhesion
    ECM-receptor interaction


    IBSP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IBSP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/20 Interacting proteins for IBSP (ENSP000002262844) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGAVENSP000002610234STRING: ENSP00000261023
    ITGB3ENSP000002620174STRING: ENSP00000262017
    ITGA1ENSP000002825884STRING: ENSP00000282588
    ITGA10ENSP000003583104STRING: ENSP00000358310
    ITGA11ENSP000003272904STRING: ENSP00000327290
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0007155cell adhesion IEA--
    GO:0030198extracellular matrix organization IEA--
    GO:0031214biomineral tissue development IEA--
    GO:0071363cellular response to growth factor stimulus IEA--


    IBSP for ontologies           About GeneDecksing



    Drugs & Compounds
    for IBSP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IBSP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IBSP
    10/67 Novoseek chemical compound relationships for IBSP gene (see all 67)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alizarin 81.1 12 16530029 (1), 15003788 (1), 17651131 (1), 19642865 (1) (see all 9)
    hydroxyapatite 77 88 8397409 (4), 9181551 (3), 7915111 (3), 15004030 (3) (see all 39)
    grgdsp 65.2 6 9639398 (3), 9699501 (1)
    grgds 57.2 3 9426405 (1), 8213261 (1), 7518179 (1)
    titanium 55.6 9 12472226 (1), 12419636 (1), 12798071 (1), 17437306 (1) (see all 5)
    dexamethasone 52.6 45 17707772 (4), 10203417 (3), 16949358 (3), 9173083 (2) (see all 15)
    deoxypyridinoline 52.6 24 10794751 (4), 11148806 (2), 8784085 (2), 11763409 (2) (see all 9)
    pyridinoline 52.2 21 10794751 (3), 11763409 (2), 8784085 (2), 11148806 (1) (see all 8)
    ascorbic acid 50 12 11771655 (1), 16934542 (1), 10920219 (1), 18617260 (1) (see all 5)
    fibroin 46.3 1 15478212 (1)

    Search CenterWatch for drugs/clinical trials and news about IBSP / SIAL 

    Transcripts
    for IBSP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IBSP gene: 
    NM_004967.3  

    Unigene Cluster for IBSP:

    Integrin-binding sialoprotein
    Hs.518726  [show with all ESTs]
    Unigene Representative Sequence: NM_004967
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000226284(uc003hqx.4)

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IBSP
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate IBSP:
    hsa-miR-4324 hsa-miR-219-1-3p hsa-miR-544b hsa-miR-571 hsa-miR-378* hsa-miR-3667-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IBSP (see all 7)
    OriGene shRNA RFP: IBSP
    OriGene siRNA: IBSP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IBSP
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IBSP (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IBSP
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: IBSP (NM_004967)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IBSP 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IBSP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IBSP

    Additional cDNA sequence: J05213.1 

    1 DOTS entry:

    DT.308799 

    24/33 AceView cDNA sequences (see all 33):

    BQ183053 CA413768 BQ028857 CA412935 AW196683 CA436814 C01831 CA412904 
    BF478125 BU615775 BQ573754 CA426254 AI963900 CA415063 BQ182386 BQ181439 
    CA427677 BI493249 AA452255 CA436452 CA427111 CA427673 AI421654 BE466675 

    GeneLoc Exon Structure


    Expression
    for IBSP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IBSP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IBSP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/22 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 22) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneAutopod PeriosteumEndochondral OsteoblastsBone
    BoneAutopod PeriosteumImmature Endochondral OsteoblastsBone
    BoneCaudal Endochondral BonesEndochondral OsteoblastsBone
    BoneCervical VertebraeEndochondral OsteoblastsBone
    BoneCervical VertebraeImmature Endochondral OsteoblastsBone
    BoneEndochondral Facial BonesEndochondral OsteoblastsBone
    BoneLumbar VertebraeEndochondral OsteoblastsBone
    BoneLumbar VertebraeImmature Endochondral OsteoblastsBone
    BoneRostral Endochondral Facial BonesEndochondral OsteoblastsBone
    BoneSacral VertebraeEndochondral OsteoblastsBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    Endometrial regenerative cell (Adult Stem / Progenitor Cell)Reproductive System
    Articular chondrocyte-like cells (HyStem chondrogenic ...)Cartilage
    HyStem+TGF?3+GDF5-induced 4D20.8 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage

    See IBSP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IBSP

    SOURCE GeneReport for Unigene cluster: Hs.518726
        SABiosciences Expression via Pathway-Focused PCR Arrays including IBSP: 
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IBSP

    Orthologs
    for IBSP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IBSP gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ibsp1 , 5 integrin binding sialoprotein1, 5 76.72(n)1
    73.33(a)1    		   5 (50.68 cM)5
    158911  NM_008318.31  NP_032344.21 
     1042991715 
    chicken
    (Gallus gallus)    		 Aves IBSP1 integrin-binding sialoprotein 55.31(n)
    44.69(a)    		   396071  NM_205162.1  NP_990493.1 
    lizard
    (Anolis carolinensis)    		 Reptilia IBSP6
    		 --
    		 43(a)
    		 1 ↔ 1
    		 5(45466256-45479171)


    ENSEMBL Gene Tree for IBSP (if available)
    TreeFam Gene Tree for IBSP (if available) 

    Paralogs
    for IBSP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for IBSP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for IBSP
         1 Indel: 51480
    Human Gene Mutation Database (HGMD): IBSP
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IBSP
    DNA2.0 Custom Variant and Variant Library Synthesis for IBSP

    Disorders / Diseases
    for IBSP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IBSP for disorders           About GeneDecksing

    OMIM gene information: 147563    OMIM disorders: --

    20/51 diseases for IBSP (see all 51):    About MalaCards
    pigmented villonodular synovitis    chondromalacia patellae    villonodular synovitis    osteogenesis imperfecta
    osteoporosis, postmenopausal    mccune albright syndrome    dentinogenesis imperfecta    fibrous dysplasia
    chondromalacia    connective tissue disease    dentin dysplasia    ankylosing spondylitis
    ritter's disease    paget's disease of bone    synovitis    arterial calcification
    osteomyelitis    osteoporosis    rheumatoid arthritis    periodontal disease

    4 diseases from the University of Copenhagen DISEASES database for IBSP:
    Dentin dysplasia     Osteoporosis     Dentinogenesis imperfecta     Chondromalacia patellae

    10/53 Novoseek disease relationships for IBSP gene (see all 53)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcification 65.4 35 8769669 (1), 9539200 (1), 16637042 (1), 9099263 (1) (see all 24)
    bone metastases 64.5 35 10804012 (4), 17213971 (3), 9157781 (3), 10632320 (3) (see all 18)
    osteosarcoma 56.1 17 12569382 (2), 15203941 (2), 9069166 (1), 10716620 (1) (see all 9)
    bone diseases 48.5 7 11125546 (1), 8990227 (1), 10632320 (1)
    collagen fibril 48.3 11 1451011 (4), 15846504 (2), 10441531 (1), 9458064 (1)
    osteolytic 40.6 4 15688393 (2), 14647232 (1)
    osteogenesis imperfecta 37.6 1 2068957 (1)
    bone tumor 30.4 1 19739076 (1)
    fibrous dysplasia 30 1 9403710 (1)
    osteoporosis 29.6 3 11125546 (2)

    Human Genome Epidemiology (HuGE) Navigator: IBSP (6 documents)

    Export disorders for IBSP gene to outside databases

    Publications
    for IBSP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IBSP gene, integrated from 9 sources (see all 591):
    (articles sorted by number of sources associating them with IBSP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human bone sialoprotein gene (IBSP): genomic localization and characterization. (PubMed id 8406493)1, 2, 3 Kerr J.M....Young M.F. (1993)
    2. Structural characterization of human recombinant and bone-derived bone sialoprotein. Functional implications for cell attachment and hydroxyapatite binding. (PubMed id 11459848)1, 2, 9 Wuttke M....Maurer P. (2001)
    3. Characterization of the human bone sialoprotein (BSP) gene and its promoter sequence. (PubMed id 8061918)1, 2, 9 Kim R.H.... Sodek J. (1994)
    4. Human bone sialoprotein. Deduced protein sequence and chromosomal localization. (PubMed id 2404984)1, 2 Fisher L.W.... Young M.F. (1990)
    5. Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone. (PubMed id 3597437)1, 2 Fisher L.W.... Termine J.D. (1987)
    6. Bone sialoprotein stimulates focal adhesion-related s ignaling pathways: role in migration and survival of breast and prostate cancer cells. (PubMed id 19492334)1, 9 Gordon J.A....Goldberg H.A. (2009)
    7. Bone sialoprotein and its transcriptional regulatory mechanism. (PubMed id 18302613)1, 9 Ogata Y. (2008)
    8. Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells. (PubMed id 12750290)1, 9 Barnes G.L....Gerstenfeld L.C. (2003)
    9. Predictive significance of bone sialoprotein and oste opontin for bone metastases in resected Chinese non-small-cell lung cancer pati ents: a large cohort retrospective study. (PubMed id 19376608)1, 9 Zhang L....Wang X. (2010)
    10. Bone sialoprotein does not interact with pro-gelatinase A (MMP-2) or mediate MMP-2 activation. (PubMed id 19386107)1, 9 Hwang Q....Sodek J. (2009)

    External Searches for IBSP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing IBSP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3381 HGNC: 5341 AceView: IBSP Ensembl:ENSG00000029559 euGenes: HUgn3381
    ECgene: IBSP Kegg: 3381 H-InvDB: IBSP

    Other Databases showing IBSP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IBSP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IBSP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IBSP Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for IBSP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IBSP gene:
    Search GeneIP for patents involving IBSP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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