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Aliases for IBSP Gene

Aliases for IBSP Gene

  • Integrin-Binding Sialoprotein 2 3 4
  • Bone Sialoprotein II 2 3 4
  • Cell-Binding Sialoprotein 3 4
  • BSP II 3 4
  • BNSP 3 4
  • Bone Sialoprotein 2 3
  • Bone Sialoprotein 2
  • BSP-II 3
  • SP-II 3
  • BSP 3

External Ids for IBSP Gene

Previous GeneCards Identifiers for IBSP Gene

  • GC04P088878
  • GC04P089022
  • GC04P089179
  • GC04P089077
  • GC04P088939
  • GC04P088720
  • GC04P084466

Summaries for IBSP Gene

Entrez Gene Summary for IBSP Gene

  • The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for IBSP Gene

IBSP (Integrin-Binding Sialoprotein) is a Protein Coding gene. Diseases associated with IBSP include pigmented villonodular synovitis and villonodular synovitis. Among its related pathways are PI3K-Akt signaling pathway and Focal adhesion.

UniProtKB/Swiss-Prot for IBSP Gene

  • Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment

Gene Wiki entry for IBSP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IBSP Gene

Genomics for IBSP Gene

Regulatory Elements for IBSP Gene

Genomic Location for IBSP Gene

87,799,550 bp from pter
87,812,449 bp from pter
12,900 bases
Plus strand

Genomic View for IBSP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IBSP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IBSP Gene

Proteins for IBSP Gene

  • Protein details for IBSP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bone sialoprotein 2
    Protein Accession:
    Secondary Accessions:

    Protein attributes for IBSP Gene

    317 amino acids
    Molecular mass:
    35148 Da
    Quaternary structure:
    No Data Available
    • It is possible that the segments of clustered carboxyl groups mediate the strong binding to hydroxyapatite

neXtProt entry for IBSP Gene

Proteomics data for IBSP Gene at MOPED

Post-translational modifications for IBSP Gene

  • N-glycosylated; glycans consist of sialylated and core-fucosylated bi-, tri- and tetraantennary chains.
  • O-glycosylated at eight sites; mucin-type glycans contain Gal, GlcNAc, GalNAc and terminal NeuAc.
  • Sulfated on either Tyr-313 or Tyr-314.
  • Glycosylation at Asn104, Thr119, Thr122, Asn177, Asn182, Asn190, Thr227, Thr228, Thr229, Thr238, and Thr239
  • Modification sites at PhosphoSitePlus

Other Protein References for IBSP Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for IBSP (IBSP/Sialoprotein II)
  • Cell Signaling Technology (CST) Antibodies for IBSP (Sialoprotein-2)

No data available for DME Specific Peptides for IBSP Gene

Domains for IBSP Gene

Protein Domains for IBSP Gene


Suggested Antigen Peptide Sequences for IBSP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IBSP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for IBSP Gene

Function for IBSP Gene

Molecular function for IBSP Gene

GENATLAS Biochemistry: sialoprotein,bone (cell adhesion molecule,RGD containing)
UniProtKB/Swiss-Prot Function: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment

Gene Ontology (GO) - Molecular Function for IBSP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with IBSP: view
genes like me logo Genes that share phenotypes with IBSP: view

Animal Models for IBSP Gene

MGI Knock Outs for IBSP:

Animal Model Products

CRISPR Products

miRNA for IBSP Gene

miRTarBase miRNAs that target IBSP

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IBSP Gene

Localization for IBSP Gene

Subcellular locations from UniProtKB/Swiss-Prot for IBSP Gene


Subcellular locations from

Jensen Localization Image for IBSP Gene COMPARTMENTS Subcellular localization image for IBSP gene
Compartment Confidence
extracellular 5
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IBSP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space ISS --
GO:0016020 membrane IDA 16210410
GO:0031988 membrane-bounded vesicle ISS --
genes like me logo Genes that share ontologies with IBSP: view

Pathways for IBSP Gene

genes like me logo Genes that share pathways with IBSP: view

Pathways by source for IBSP Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for IBSP Gene

Gene Ontology (GO) - Biological Process for IBSP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification --
GO:0001649 osteoblast differentiation IDA 16210410
GO:0007155 cell adhesion ISS --
GO:0030198 extracellular matrix organization TAS --
GO:0031214 biomineral tissue development IEA --
genes like me logo Genes that share ontologies with IBSP: view

Compounds for IBSP Gene

(67) Novoseek inferred chemical compound relationships for IBSP Gene

Compound -log(P) Hits PubMed IDs
alizarin 81.1 9
hydroxyapatite 77 54
grgdsp 65.2 4
grgds 57.2 3
titanium 55.6 5
genes like me logo Genes that share compounds with IBSP: view

Transcripts for IBSP Gene

mRNA/cDNA for IBSP Gene

(33) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IBSP Gene

Integrin-binding sialoprotein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IBSP

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for IBSP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IBSP Gene

No ASD Table

Relevant External Links for IBSP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IBSP Gene

mRNA expression in normal human tissues for IBSP Gene

mRNA differential expression in normal tissues according to GTEx for IBSP Gene

This gene is overexpressed in Artery - Coronary (10.7), Pituitary (7.2), and Brain - Amygdala (5.0).

SOURCE GeneReport for Unigene cluster for IBSP Gene Hs.518726

genes like me logo Genes that share expressions with IBSP: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for IBSP Gene

Orthologs for IBSP Gene

This gene was present in the common ancestor of chordates.

Orthologs for IBSP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IBSP 35
  • 98.53 (n)
  • 97.79 (a)
  • 98 (a)
(Bos Taurus)
Mammalia IBSP 35
  • 80.68 (n)
  • 76.49 (a)
  • 77 (a)
(Canis familiaris)
Mammalia IBSP 35
  • 81.73 (n)
  • 75.96 (a)
  • 79 (a)
(Mus musculus)
Mammalia Ibsp 35
  • 71.96 (n)
  • 66.35 (a)
Ibsp 16
Ibsp 36
  • 71 (a)
(Monodelphis domestica)
Mammalia IBSP 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia IBSP 36
  • 58 (a)
(Rattus norvegicus)
Mammalia Ibsp 35
  • 70.58 (n)
  • 65.71 (a)
(Gallus gallus)
Aves IBSP 36
  • 41 (a)
(Anolis carolinensis)
Reptilia IBSP 36
  • 41 (a)
Species with no ortholog for IBSP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IBSP Gene

Gene Tree for IBSP (if available)
Gene Tree for IBSP (if available)

Paralogs for IBSP Gene

No data available for Paralogs for IBSP Gene

Variants for IBSP Gene

Sequence variations from dbSNP and Humsavar for IBSP Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs958479 -- 87,800,630(-) AAAAG(G/T)TCTTG intron-variant
rs1054627 - 87,811,540(+) CGGAG(A/G)AGACA missense, reference
rs1054628 - 87,811,759(+) GGGCG(C/T)CAATG reference, missense
rs1054629 - 87,811,766(+) AATGA(A/T)TACGA reference, missense
rs1381965 -- 87,807,752(-) AAATG(G/T)TCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IBSP Gene

Variant ID Type Subtype PubMed ID
nsv515943 CNV Gain+Loss 19592680
dgv322n21 CNV Loss 19592680

Relevant External Links for IBSP Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IBSP Gene

Disorders for IBSP Gene

(53) Novoseek inferred disease relationships for IBSP Gene

Disease -log(P) Hits PubMed IDs
calcification 65.4 24
bone metastases 64.5 27
osteosarcoma 56.1 11
bone diseases 48.5 3
collagen fibril 48.3 8

Relevant External Links for IBSP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IBSP: view

No data available for UniProtKB/Swiss-Prot for IBSP Gene

Publications for IBSP Gene

  1. Characterization of the human bone sialoprotein (BSP) gene and its promoter sequence. (PMID: 8061918) Kim R.H. … Sodek J. (Matrix Biol. 1994) 3 4 23
  2. Structural characterization of human recombinant and bone-derived bone sialoprotein. Functional implications for cell attachment and hydroxyapatite binding. (PMID: 11459848) Wuttke M. … Maurer P. (J. Biol. Chem. 2001) 3 4 23
  3. The human bone sialoprotein gene (IBSP): genomic localization and characterization. (PMID: 8406493) Kerr J.M. … Young M.F. (Genomics 1993) 2 3 4
  4. Human bone sialoprotein. Deduced protein sequence and chromosomal localization. (PMID: 2404984) Fisher L.W. … Young M.F. (J. Biol. Chem. 1990) 3 4
  5. Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone. (PMID: 3597437) Fisher L.W. … Termine J.D. (J. Biol. Chem. 1987) 3 4

Products for IBSP Gene

Sources for IBSP Gene

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