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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IBSP Gene

protein-coding   GIFtS: 64
GCID: GC04P088720

Integrin-Binding Sialoprotein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Integrin-Binding Sialoprotein1 2 3     Bone Sialoprotein1
Bone Sialoprotein II1 2 3     BSP2
Cell-Binding Sialoprotein2 3     BSP-II2
BNSP2 3     SP-II2
BSP II2 3     Bone Sialoprotein 22

External Ids:    HGNC: 53411   Entrez Gene: 33812   Ensembl: ENSG000000295597   OMIM: 1475635   UniProtKB: P218153   

Export aliases for IBSP gene to outside databases

Previous GC identifers: GC04P088878 GC04P089022 GC04P089179 GC04P089077 GC04P088939 GC04P084466


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IBSP Gene:
The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately
12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including
hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis
is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and
mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. (provided by RefSeq,
Jul 2008)

GeneCards Summary for IBSP Gene: 
IBSP (integrin-binding sialoprotein) is a protein-coding gene. Diseases associated with IBSP include osteomyelitis, and villonodular synovitis, and among its related super-pathways are Focal Adhesion and Non-integrin membrane-ECM interactions.

UniProtKB/Swiss-Prot: SIAL_HUMAN, P21815
Function: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably
important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment

Gene Wiki entry for IBSP (Bone sialoprotein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IBSP gene promoter:
         TBP   AML1a   HOXA3   HSF1 (long)   MEF-2A   SRY   Nkx6-1   HSF1short   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIBSP promoter sequence
   Search SABiosciences Chromatin IP Primers for IBSP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IBSP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.1   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q21.1

IBSP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IBSP gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P088720:  view genomic region     (about GC identifiers)

Start:
88,720,702 bp from pter      End:
88,733,601 bp from pter
Size:
12,900 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SIAL_HUMAN, P21815 (See protein sequence)
Recommended Name: Bone sialoprotein 2 precursor  
Size: 317 amino acids; 35148 Da
Subcellular location: Secreted
Miscellaneous: It is possible that the segments of clustered carboxyl groups mediate the strong binding to
hydroxyapatite

Explore the universe of human proteins at neXtProt for IBSP: NX_P21815

Explore proteomics data for IBSP at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated; glycans consist of sialylated and core-fucosylated bi-, tri- and tetraantennary chains
  • UniProtKB: O-glycosylated at eight sites; mucin-type glycans contain Gal, GlcNAc, GalNAc and terminal NeuAc
  • UniProtKB: Sulfated on either Tyr-313 or Tyr-314
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P21815

  • IBSP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IBSP Protein Expression
    REFSEQ proteins: NP_004958.2  
    ENSEMBL proteins: 
     ENSP00000226284  
    Reactome Protein details: P21815
    Human Recombinant Protein Products for IBSP: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for IBSP (IBSP/Sialoprotein II)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for IBSP
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for IBSP
    GenScript Custom Purified and Recombinant Proteins Services for IBSP
    Novus Biologicals IBSP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    IBSP for ontologies           About GeneDecksing



    IBSP Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of IBSP
    R&D Systems Antibodies for IBSP (IBSP/Sialoprotein II)
    Cell Signaling Technology (CST) Antibodies for IBSP  (sialoprotein 2)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for IBSP
    GenScript Custom Superior Antibodies Services for IBSP
    Novus Biologicals IBSP Antibody
    Abcam antibodies for IBSP
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for IBSP
    LSBio Antibodies in human, mouse, rat for IBSP 

    Assay Products for IBSP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IBSP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IBSP
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR008412 BSP_II

    Graphical View of Domain Structure for InterPro Entry P21815

    ProtoNet protein and cluster: P21815

    1 Blocks protein domain: IPB008412 Bone sialoprotein II


    IBSP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SIAL_HUMAN, P21815
    Function: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably
    important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment

         Genatlas biochemistry entry for IBSP:
    sialoprotein,bone (cell adhesion molecule,RGD containing)

    Phenotypes:
         5 GenomeRNAi human phenotypes for IBSP:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased cilium length after  
     Increased Salmonella enterica  

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ibsp):
     growth/size  limbs/digits/tail  skeleton 

    IBSP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ibsptm1Jeau for IBSP

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IBSP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IBSP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IBSP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IBSP 

    miRNA
    Products:
        
    miRTarBase miRNAs that target IBSP:
    hsa-mir-135b (MIRT003594)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IBSP
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate IBSP:
    hsa-miR-4324 hsa-miR-219-1-3p hsa-miR-544b hsa-miR-571 hsa-miR-378* hsa-miR-3667-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IBSP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IBSP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IBSP
    Sirion Biotech Customized adenovirus for overexpression of IBSP

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IBSP (see all 6)
    OriGene ORF clones in mouse, rat for IBSP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IBSP (NM_004967)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IBSP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IBSP
    Sirion Biotech Customized lentivirus for stable overexpression of IBSP 
                         Customized lentivirus expression plasmids for stable overexpression of IBSP 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IBSP
    LifeMap BioReagents: cell lines associated with IBSP: Osteogenic Package 4D20.8,
    Osteogenic Package SK11, Osteogenic Package SM30
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IBSP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IBSP About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal Adhesion0.64
    Focal adhesion0.64
    2Non-integrin membrane-ECM interactions
    ECM-receptor interaction0.42
    Integrin cell surface interactions0.32
    3Development Hedgehog and PTH signaling pathways in bone and cartilage development
    Development Hedgehog and PTH signaling pathways in bone and cartilage development0.97
    4Signaling by GPCR
    Signal Transduction0.55
    5Osteoblast Signaling
    Osteoblast Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for IBSP
        Development Hedgehog and PTH signaling pathways in bone and cartilage development


    2 Cell Signaling Technology (CST) Pathways for IBSP
        Cytoskeletal Signaling
    Adhesion

    1 GeneGo (Thomson Reuters) Pathway for IBSP
        Development Hedgehog and PTH signaling pathways in bone and cartilage development

    3 BioSystems Pathways for IBSP
        Focal Adhesion
    Interleukin-11 Signaling Pathway
    Osteoblast Signaling

    2        Reactome Pathways for IBSP
        Integrin cell surface interactions
    Signal Transduction


    3         Kegg Pathways  (Kegg details for IBSP):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction


    IBSP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IBSP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/20 Interacting proteins for IBSP (ENSP000002262844) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGAVENSP000002610234STRING: ENSP00000261023
    ITGA1ENSP000002825884STRING: ENSP00000282588
    ITGA10ENSP000003583104STRING: ENSP00000358310
    ITGA11ENSP000003272904STRING: ENSP00000327290
    ITGA2ENSP000002965854STRING: ENSP00000296585
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0007155cell adhesion IEA--
    GO:0030198extracellular matrix organization IEA--
    GO:0031214biomineral tissue development IEA--
    GO:0071363cellular response to growth factor stimulus IEA--

    IBSP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IBSP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IBSP (SIAL)

    10/67 Novoseek inferred chemical compound relationships for IBSP gene (see all 67)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alizarin 81.1 12 16530029 (1), 15003788 (1), 17651131 (1), 19642865 (1) (see all 9)
    hydroxyapatite 77 88 8397409 (4), 9181551 (3), 7915111 (3), 15004030 (3) (see all 39)
    grgdsp 65.2 6 9639398 (3), 9699501 (1)
    grgds 57.2 3 9426405 (1), 8213261 (1), 7518179 (1)
    titanium 55.6 9 12472226 (1), 12419636 (1), 12798071 (1), 17437306 (1) (see all 5)
    dexamethasone 52.6 45 17707772 (4), 10203417 (3), 16949358 (3), 9173083 (2) (see all 15)
    deoxypyridinoline 52.6 24 10794751 (4), 11148806 (2), 8784085 (2), 11763409 (2) (see all 9)
    pyridinoline 52.2 21 10794751 (3), 11763409 (2), 8784085 (2), 11148806 (1) (see all 8)
    ascorbic acid 50 12 11771655 (1), 16934542 (1), 10920219 (1), 18617260 (1) (see all 5)
    fibroin 46.3 1 15478212 (1)

    Search CenterWatch for drugs/clinical trials and news about IBSP / SIAL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IBSP gene: 
    NM_004967.3  

    Unigene Cluster for IBSP:

    Integrin-binding sialoprotein
    Hs.518726  [show with all ESTs]
    Unigene Representative Sequence: NM_004967
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000226284(uc003hqx.4)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IBSP
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate IBSP:
    hsa-miR-4324 hsa-miR-219-1-3p hsa-miR-544b hsa-miR-571 hsa-miR-378* hsa-miR-3667-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IBSP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IBSP
    Clone
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    OriGene clones in human, mouse for IBSP (see all 6)
    OriGene ORF clones in mouse, rat for IBSP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IBSP (NM_004967)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IBSP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IBSP
    Sirion Biotech Customized lentivirus for stable overexpression of IBSP 
                         Customized lentivirus expression plasmids for stable overexpression of IBSP 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for IBSP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IBSP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IBSP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IBSP

    Additional mRNA sequence: J05213.1 

    1 DOTS entry:

    DT.308799 

    24/33 AceView cDNA sequences (see all 33):

    BQ573754 CA412904 CA436814 CA412935 AW196683 BQ183053 C01831 CA413768 
    BF478125 BU615775 BQ028857 BQ181439 CA415063 CA426254 CA427677 CA436452 
    AI963900 CA427111 BQ182386 CA427673 AA452255 BI493249 AI421654 BE466675 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IBSP expression in normal human tissues (normalized intensities)      IBSP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IBSP Expression
    About this image


    IBSP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 28 entries
             Endochondral Osteoblasts Rostral Endochondral Facial Bones
             Thoracic Rib
             HyStem+BMP4-induced 4D20.8 cells
             skeleton/cranium/viscerocranium   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+BMP4-induced 4D20.8 cells
             skeleton/cranium/viscerocranium   
     
     Tooth (Integumentary System)    fully expand to see all 3 entries
             Cementoblasts Dental Pulp
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             retinal progenitor cell e12.5   
     
     Ear (Sensory Organs)    fully expand to see all 2 entries
             stria vascularis   

    See IBSP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IBSP

    SOURCE GeneReport for Unigene cluster: Hs.518726
        SABiosciences Expression via Pathway-Focused PCR Arrays including IBSP: 
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for IBSP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IBSP
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IBSP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IBSP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IBSP gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ibsp1 , 5 integrin binding sialoprotein1, 5 76.72(n)1
    73.33(a)1
      5 (50.68 cM)5
    158911  NM_008318.31  NP_032344.21 
     1042991715 
    chicken
    (Gallus gallus)
    Aves IBSP1 integrin-binding sialoprotein 55.31(n)
    44.69(a)
      396071  NM_205162.1  NP_990493.1 
    lizard
    (Anolis carolinensis)
    Reptilia IBSP6
    integrin-binding sialoprotein
    33(a)
    1 ↔ 1
    5(45461246-45479496)


    ENSEMBL Gene Tree for IBSP (if available)
    TreeFam Gene Tree for IBSP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/320 SNPs in IBSP are shown (see all 320)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs131330881,2
    C--88718892(+) tgggcA/Gaagga 1 -- us2k11Minor allele frequency- G:0.00NA 2
    rs74359741,2
    C--88718909(+) cagacC/Acttct 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs131393361,2
    A--88719450(+) ctatcA/Gcaaga 1 -- us2k10--------
    rs285442461,2
    --88719649(+) CATGTA/GTACGT 1 -- us2k10--------
    rs2014199191,2
    C--88719668(+) ACCTG-/CACACAA 1 -- us2k10--------
    rs1910596051,2
    --88719778(+) ACTTCA/GCAACT 1 -- us2k10--------
    rs1496822651,2
    --88719784(+) CAACTA/GGAGGA 1 -- us2k10--------
    rs757110331,2
    C,F--88719873(+) TAGTTT/CATCAA 1 -- us2k11Minor allele frequency- C:0.03EA 120
    rs1455084521,2
    --88719881(+) CAATCC/TATTCT 1 -- us2k10--------
    rs1827906711,2
    --88719893(+) TGTGGC/TGTTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IBSP (88720702 - 88733601 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IBSP:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv322n21CNV Loss19592680
    nsv515943CNV Gain+Loss19592680


    Human Gene Mutation Database (HGMD): IBSP
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IBSP
    DNA2.0 Custom Variant and Variant Library Synthesis for IBSP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 147563    OMIM disorders: --

    20/48 diseases for IBSP (see all 48):    About MalaCards
    osteomyelitis    villonodular synovitis    pigmented villonodular synovitis    osteoporosis, postmenopausal
    periostitis    chondromalacia patellae    chondromalacia    ritter's disease
    fibrous dysplasia    osteoporotic fracture    mccune albright syndrome    synovitis
    dentin dysplasia    prostate adenocarcinoma    paget's disease of bone    osteogenesis imperfecta
    dentinogenesis imperfecta    periodontal disease    osteosarcoma    thyroid cancer

    4 diseases from the University of Copenhagen DISEASES database for IBSP:
    Dentin dysplasia     Dentinogenesis imperfecta     Osteoporosis     Chondromalacia patellae

    IBSP for disorders           About GeneDecksing

    10/53 Novoseek inferred disease relationships for IBSP gene (see all 53)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcification 65.4 35 8769669 (1), 9539200 (1), 16637042 (1), 9099263 (1) (see all 24)
    bone metastases 64.5 35 10804012 (4), 17213971 (3), 9157781 (3), 10632320 (3) (see all 18)
    osteosarcoma 56.1 17 12569382 (2), 15203941 (2), 9069166 (1), 10716620 (1) (see all 9)
    bone diseases 48.5 7 11125546 (1), 8990227 (1), 10632320 (1)
    collagen fibril 48.3 11 1451011 (4), 15846504 (2), 10441531 (1), 9458064 (1)
    osteolytic 40.6 4 15688393 (2), 14647232 (1)
    osteogenesis imperfecta 37.6 1 2068957 (1)
    bone tumor 30.4 1 19739076 (1)
    fibrous dysplasia 30 1 9403710 (1)
    osteoporosis 29.6 3 11125546 (2)

    Genetic Association Database (GAD): IBSP
    Human Genome Epidemiology (HuGE) Navigator: IBSP (6 documents)

    Export disorders for IBSP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IBSP gene, integrated from 9 sources (see all 594):
    (articles sorted by number of sources associating them with IBSP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human bone sialoprotein gene (IBSP): genomic localization and characterization. (PubMed id 8406493)1, 2, 3 Kerr J.M....Young M.F. (1993)
    2. Structural characterization of human recombinant and bone-derived bone sialoprotein. Functional implications for cell attachment and hydroxyapatite binding. (PubMed id 11459848)1, 2, 9 Wuttke M....Maurer P. (2001)
    3. Characterization of the human bone sialoprotein (BSP) gene and its promoter sequence. (PubMed id 8061918)1, 2, 9 Kim R.H.... Sodek J. (1994)
    4. Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture ri sk. (PubMed id 21533022)1, 4 Duncan E.L....Brown M.A. (2011)
    5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    6. New sequence variants associated with bone mineral density. (PubMed id 19079262)1, 4 Styrkarsdottir U....Stefansson K. (2009)
    7. Human bone sialoprotein. Deduced protein sequence and chromosomal localization. (PubMed id 2404984)1, 2 Fisher L.W.... Young M.F. (1990)
    8. Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone. (PubMed id 3597437)1, 2 Fisher L.W.... Termine J.D. (1987)
    9. Bone sialoprotein stimulates focal adhesion-related s ignaling pathways: role in migration and survival of breast and prostate cancer cells. (PubMed id 19492334)1, 9 Gordon J.A....Goldberg H.A. (2009)
    10. Bone sialoprotein and its transcriptional regulatory mechanism. (PubMed id 18302613)1, 9 Ogata Y. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3381 HGNC: 5341 AceView: IBSP Ensembl:ENSG00000029559 euGenes: HUgn3381
    ECgene: IBSP Kegg: 3381 H-InvDB: IBSP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IBSP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IBSP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IBSP gene:
    Search GeneIP for patents involving IBSP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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