Aliases for IBSP Gene
External Ids for IBSP Gene
The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]
GeneCards Summary for IBSP Gene
IBSP (Integrin-Binding Sialoprotein) is a Protein Coding gene. Diseases associated with IBSP include osteomyelitis and pigmented villonodular synovitis. Among its related pathways are PI3K-Akt signaling pathway and Focal adhesion.
UniProtKB/Swiss-Prot for IBSP Gene
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment