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IBSP Gene

protein-coding GIFtS: 57

GC04P088939

integrin-binding sialoprotein
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BNSP ^², ³
BSP ^¹, ²
BSP-II ^¹, ²
SP-II ^¹, ²

Descriptions
BSP II ^³
Bone sialoprotein II ^², ³
Cell-binding sialoprotein ^³
integrin-binding sialoprotein ^², ³

External Ids
HGNC: 5341¹
Entrez Gene: 3381²
UniProtKB: P21815³
Ensembl: ENSG00000029559⁷

Search outside databases for aliases for IBSP gene

Previous GC identifers: GC04P088878 GC04P089022 GC04P089179 GC04P089077

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IBSP:

The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes

approximately 12% of the noncollagenous proteins in human bone and is synthesized by

skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and

osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds

to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment

through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq]

UniProtKB/Swiss-Prot: SIAL_HUMAN, P21815

Function: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized

matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell

attachment

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IBSP gene

Entrez Gene cytogenetic band: 4q21-q25 Ensembl cytogenetic band: 4q22.1 HGNC cytogenetic band: 4q21.1

IBSP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P088939: (about GC identifiers)

Start:	88,939,726 bp from pter
End:	88,952,098 bp from pter
Size:	12,373 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000004.10 NT_016354.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SIAL_HUMAN, P21815 (See protein sequence)

Recommended Name: Bone sialoprotein 2 precursor

Size: 317 amino acids; 35018 Da

Subcellular location: Secreted

Miscellaneous: It is possible that the segments of clustered carboxyl groups mediate the strong

binding to hydroxyapatite

Post-translational modifications:

N-glycosylated; glycans consist of sialated and core-fucosylated bi-, tri- and tetraantennary

chains¹

O-glycosylated at eight sites; mucin-type glycans contain Gal, GlcNAc, GalNAc and terminal NeuAc¹

Sulfated on either Tyr-313 or Tyr-314¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004958.2

ENSEMBL proteins:

ENSP00000226284

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for IBSP (IBSP/Sialoprotein II)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Bone Sialoprotein)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

About this table

Antibodies for IBSP:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of IBSP
	Sigma-Aldrich Antibodies for IBSP
	R&D Systems Antibodies for IBSP (IBSP/Sialoprotein II)
	Antibodies from Abcam (Bone Sialoprotein), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for IBSP

Assays for IBSP:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P21815

ProtoNet protein and cluster: P21815

1 Blocks protein family: IPB008412 Bone sialoprotein II

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IBSP)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004967

Applied Biosystems Silencer® siRNAs for IBSP

Sigma-Aldrich siRNA for IBSP

Sigma-Aldrich shRNA for IBSP

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004967
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004967
untagged cDNA clone in CMV expression vector: NM_004967

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004967

UniProtKB/Swiss-Prot: SIAL_HUMAN, P21815

Function: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized

matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell

attachment

Genatlas biochemistry entry for IBSP:

sialoprotein,bone (cell adhesion molecule,RGD containing)

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ibsp):

growth/size

limbs/digits/tail

skeleton

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for IBSP

5/69 Interacting proteins for IBSP (ENSP00000226284³) via UniProtKB, MINT, and/or STRING (see all 69 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SPP1	ENSP00000237623³	STRING (score=.979)
RUNX2	ENSP00000352514³	STRING (score=.948)
VWF	ENSP00000261405³	STRING (score=.942)
FN1	ENSP00000323534³	STRING (score=.935)
COL1A1	ENSP00000225964³	STRING (score=.915)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001503	ossification	IEA	--
GO:0007155	cell adhesion	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IBSP
10/47 Novoseek chemical compound relationships for IBSP gene (see all 47 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
alizarin	79.61	10	16530029 (1), 15003788 (1), 17651131 (1), 15853967 (1) (see all 7)
hydroxyapatite	76.88	81	8397409 (4), 9181551 (3), 7915111 (3), 15004030 (3) (see all 36)
grgdsp	66.42	6	9639398 (3), 9699501 (1)
deoxypyridinoline	54.15	24	10794751 (4), 11148806 (2), 8784085 (2), 11763409 (2) (see all 9)
pyridinoline	53.58	21	10794751 (3), 11763409 (2), 8784085 (2), 11148806 (1) (see all 8)
titanium	51.85	9	12472226 (1), 12419636 (1), 12798071 (1), 17437306 (1) (see all 5)
strontium ranelate	48.27	5	17300752 (2), 17579299 (1), 17945546 (1)
fibroin	44.04	1	15478212 (1)
calcium	40.63	21	1447223 (3), 16327496 (1), 16637042 (1), 9893065 (1) (see all 16)
toluidine	35.98	1	15642592 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IBSP)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004967

Sigma-Aldrich siRNA for IBSP

Sigma-Aldrich shRNA for IBSP

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004967

REFSEQ mRNAs for IBSP gene:

NM_004967.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004967

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004967
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004967
                                 untagged cDNA clone in CMV expression vector: NM_004967

Additional cDNA sequence: J05213.1

1 DOTS entry:

DT.308799

24/33 AceView cDNA sequences (see all 33 ):

BQ573754 BQ028857 CA412935 C01831 CA413768 CA412904 BQ183053 CA436814

AW196683 BF478125 BU615775 CA415063 BI493249 CA427677 AI963900 CA427673

AA452255 CA436452 BQ182386 CA426254 CA427111 BQ181439 N66529 J05213

highest scoring ESTs for IBSP:

J05213 AA452431 AI421654 BE466675 BQ028857 BQ182386 CA412904 CA412935 CA413768 CA415063

Unigene Cluster for IBSP:

Integrin-binding sialoprotein

Hs.518726 [show with all ESTs]

Unigene Representative Sequence: NM_004967

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000226284

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IBSP expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IBSP

¹ / ² / ³

6 probe-sets matching IBSP gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35131_at²^{, 3}	U95-A	1	1.00	1.00	0.78	1.18	J05213	1.00	1.00	1.00	1
53238_at²^{, 3}	U95-C	1	0.94	1.00	0.92	1.15	AI421654	0.80	1.00	0.91	1
236028_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BE466675	0.80	1.00	0.91	1
207370_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004967	0.60	1.00	0.82	1
236028_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207370_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.518726
Expression variation in blood from EXPOLDB for IBSP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IBSP gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IBSP¹	--	integrin-binding sialoprotein	85.96(n) 82.32(a)	609146 XM_846356.1 XP_851449.1
chimpanzee (Pan troglodytes)	IBSP¹	--	integrin-binding sialoprotein	98.74(n) 98.11(a)	471249 XM_526631.2 XP_526631.1
cow (Bos taurus)	IBSP¹	--	integrin-binding sialoprotein	84(n) 81.79(a)	281233 NM_174084.2 NP_776509.1
rat (Rattus norvegicus)	Ibsp¹	--	integrin binding sialoprotein	74.5(n) 71.43(a)	24477 NM_012587.1 NP_036719.1
mouse (Mus musculus)	Ibsp^{1, 5}	5 (56.00 cM)⁵	integrin binding sialoprotein^{1, 5}	76.54(n)¹ 73.89(a)¹	15891¹ NM_008318.1¹ NP_032344.1¹ AK132371⁵ AK162640⁵ (see all 10)

About this table Species with no ortholog for IBSP

ENSEMBL Gene Tree for IBSP

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/77 NCBI SNPs in IBSP are shown (see all 77 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 50)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1054629^1,2	C,F,H,O	88951942(+)	`AATGAA/TTACGA`	1	E/D	mis¹ ese³		13		MN NA EU EA WA	1232
	rs17013187^1,2	C,F,H	88952555(+)	`GTGACC/TTGTAT`	1	--	ut3¹		7		NA EU EA WA	560
	rs13144371^1,2	C,F,H	88951770(+)	`AGAAGG/ACACCA`	1	G/D	mis¹ ese³		12		NA EU EA WA	1034
	rs17013182^1,2	C,F,H	88951898(+)	`CCACCA/GCCGTT`	1	T/A	mis¹ ese³		12		NA EU EA WA	1052
	rs17013181^1,2	C,F,H	88951787(+)	`CCGGAA/GGGCAG`	1	R/G	mis¹ ese³		13		NA EA EU WA	1100
	rs1054628^1,2	C,F,H	88951935(+)	`GGGCGC/TCAATG`	1	A/V	mis¹ ese³		14		MN EA NA EU WA	1302
	rs1054627^1,2	C,F,H	88951716(+)	`CGGAGG/AAGACA`	1	E/G	mis¹ ese³		13		MN EA NA EU WA	1238
	rs1903798^1,2	A,H	88939042(-)	`TTTTTC/TCTTGG`	1	--	ng5¹ trp³		3		EU EA	298
--	rs7435974^1,2	C	88937933(+)	`cagacA/Ccttct`	1	--	ng5¹		0	--	--	--	--
	rs3805378^1,2	C	88939418(-)	`AATTAC/TACAAG`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for IBSP (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 147563

10/52 Novoseek disease relationships for IBSP gene (see all 52 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
bone metastases	64.80	33	10804012 (4), 17213971 (3), 9157781 (3), 10632320 (3) (see all 16)
calcification	64.74	35	8769669 (1), 9539200 (1), 16637042 (1), 9099263 (1) (see all 24)
osteosarcoma	57.33	17	12569382 (2), 15203941 (2), 9069166 (1), 10716620 (1) (see all 9)
bone diseases	50.81	7	11125546 (1), 8990227 (1), 10632320 (1)
collagen fibril	48.12	11	1451011 (4), 15846504 (2), 10441531 (1), 9458064 (1)
osteolytic	43.00	4	15688393 (2), 14647232 (1)
osteogenesis imperfecta	39.79	1	2068957 (1)
osteoporosis	32.35	3	11125546 (2)
bone lesion	32.13	1	14524533 (1)
lytic lesion	31.99	1	15688393 (1)

About this table

Human Genome Epidemiology Navigator: IBSP (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/517 PubMed articles for IBSP gene (see all 517 ):

The human bone sialoprotein gene (IBSP): genomic localization and characterization. (PubMed id 8406493)^{2, 3, 4} Kerr J.M....Young M.F. (1993)
Structural characterization of human recombinant and bone-derived bone sialoprotein. Functional implications for cell attachment and hydroxyapatite binding. (PubMed id 11459848)^{1, 3, 4} Wuttke M....Maurer P. (2001)
Characterization of the human bone sialoprotein (BSP) gene and its promoter sequence. (PubMed id 8061918)^{1, 3, 4} Kim R.H.... Sodek J. (1994)
Human bone sialoprotein. Deduced protein sequence and chromosomal localization. (PubMed id 2404984)^{3, 4} Fisher L.W.... Young M.F. (1990)
Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone. (PubMed id 3597437)^{3, 4} Fisher L.W.... Termine J.D. (1987)
Bone sialoprotein and its transcriptional regulatory mechanism. (PubMed id 18302613)^{1, 3} Ogata Y. (2008)
Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells. (PubMed id 12750290)^{1, 3} Barnes G.L....Gerstenfeld L.C. (2003)
Runx2- and histone deacetylase 3-mediated repression is relieved in differentiating human osteoblast cells to allow high bone sialoprotein expression. (PubMed id 17956871)^{1, 3} Lamour V....Bellahcene A. (2007)
Bone sialoprotein enhances migration of bone marrow stromal cells through matrices by bridging MMP-2 to alpha(v)beta3-integrin. (PubMed id 16995818)^{1, 3} Karadag A. and Fisher L.W. (2006)
Posttranslational modifications to human bone sialoprotein determined by mass spectrometry. (PubMed id 11669636)^{1, 4} Zaia J....Barry F. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3381	HGNC: 5341	AceView: IBSP	Ensembl:ENSG00000029559	euGenes: HUgn3381
ECgene: IBSP	H-InvDB: IBSP

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for IBSP	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for IBSP
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for IBSP:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IBSP-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IBSP		Antibodies for IBSP
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IBSP		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Recombinant & Natural Proteins

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IBSP Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for IBSP

Summaries
for IBSP

Genomic Location
for IBSP

Proteins
for IBSP

Protein Domains/
Families
for IBSP

Gene Function
for IBSP

Pathways & Interactions
for IBSP

Drugs & Compounds
for IBSP

Transcripts
for IBSP

Expression
for IBSP

Orthologs
for IBSP

Paralogs
for IBSP

SNPs/Variants
for IBSP

Disorders & Mutations
for IBSP

Medical News
for IBSP

Publications
for IBSP

Search for IBSP

Genome Databases showing IBSP

Other Databases showing IBSP

Specialized Databases showing IBSP

Licensable Technologies
for IBSP

Services
for IBSP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IBSP Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor IBSP

Summariesfor IBSP

Genomic Locationfor IBSP

Proteinsfor IBSP

Protein Domains/Familiesfor IBSP

Gene Functionfor IBSP

Pathways & Interactionsfor IBSP

Drugs & Compoundsfor IBSP

Transcriptsfor IBSP

Expression for IBSP

Orthologsfor IBSP

Paralogsfor IBSP

SNPs/Variantsfor IBSP

Disorders & Mutationsfor IBSP

Medical Newsfor IBSP

Publicationsfor IBSP

Search for IBSP

Genome Databases showing IBSP

Other Databases showing IBSP

Specialized Databases showing IBSP

Licensable Technologiesfor IBSP

Servicesfor IBSP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IBSP

Summaries
for IBSP

Genomic Location
for IBSP

Proteins
for IBSP

Protein Domains/
Families
for IBSP

Gene Function
for IBSP

Pathways & Interactions
for IBSP

Drugs & Compounds
for IBSP

Transcripts
for IBSP

Expression
for IBSP

Orthologs
for IBSP

Paralogs
for IBSP

SNPs/Variants
for IBSP

Disorders & Mutations
for IBSP

Medical News
for IBSP

Publications
for IBSP

Licensable Technologies
for IBSP

Services
for IBSP