IBA57 Gene
protein-coding GIFtS: 39
GCID: GC01P228354
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IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)(Previous name: chromosome 1 open reading frame 69 )
(Previous symbol: C1orf69)
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Aliases
for IBA57 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| IBA57, Iron-Sulfur Cluster Assembly Homolog (S. Cerevisiae)1 2 | | Iron-Sulfur Cluster Assembly Factor For Biotin Synthase- And Aconitase-LikeMitochondrial Proteins, With A Mass Of 57kDa2 | | C1orf691 2 3 | | Putative Transferase C1orf69, Mitochondrial2 | | Iron-Sulfur Cluster Assembly Factor Homolog2 3 | | Putative Transferase CAF17, Mitochondrial2 | | FLJ127341 | | EC 2.1.-.-3 | | Chromosome 1 Open Reading Frame 691 | | |
Export aliases for IBA57 gene to outside databases |
Summaries
for IBA57 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CAF17_HUMAN, Q5T440Function: Required for normal heme biosynthesis (By similarity)
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Genomic Views
for IBA57 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for IBA57
Other transcription factors
Search SABiosciences Chromatin IP Primers for IBA57
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IBA57 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q42.13 Ensembl cytogenetic band: 1q42.13 HGNC cytogenetic band: 1q42.13IBA57 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P228354: view genomic region
(about GC identifiers)
Start:
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228,353,429 bp from pter |
End:
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228,369,958 bp from pter |
Size:
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16,530 bases |
Orientation:
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plus strand |
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Proteins
for IBA57 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CAF17_HUMAN, Q5T440 (See
protein sequence)Recommended Name: Putative transferase CAF17, mitochondrial precursor Size: 356 amino acids; 38155 Da
Subcellular location: Mitochondrion (Potential)Explore the universe of human proteins at neXtProt for IBA57: NX_Q5T440
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T440
IBA57 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001010867.1
ENSEMBL proteins: ENSP00000355672 ENSP00000437347
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
IBA57 for ontologies About GeneDecksing
IBA57 Antibody Products:
Assay Products for IBA57: |
Protein
Domains /
Families
for IBA57 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IBA57 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5T440ProtoNet protein and cluster: Q5T440 UniProtKB/Swiss-Prot: CAF17_HUMAN, Q5T440Similarity: Belongs to the GcvT family. CAF17 subfamily |
Function
for IBA57 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CAF17_HUMAN, Q5T440Function: Required for normal heme biosynthesis (By similarity)Enzyme Number (IUBMB): EC 2.1.-.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IBA57 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IBA57
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IBA57 (NM_001010867) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IBA57 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IBA57 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IBA57 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004047 | aminomethyltransferase activity |
IEA | -- |
IBA57 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for IBA57:
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Pathways & Interactions
for IBA57 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IBA57
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for IBA57 (Q5T4403 ENSP000003556724) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006546 | glycine catabolic process |
IEA | -- | | GO:0006783 | heme biosynthetic process |
IEA | -- |
IBA57 for ontologies About GeneDecksing
|
Drugs & Compounds
for IBA57 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IBA57
Search CenterWatch for drugs/clinical trials and news about IBA57 / CAF17
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Transcripts
for IBA57 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IBA57 gene: NM_001010867.2 Unigene Clusters for IBA57: IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae) Hs.237017 [show with all ESTs], Hs.636881 Unigene Representative Sequences: NM_001010867, AK0239113 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000366711(uc001hsl.4 uc010pvw.2) ENST00000484749 ENST00000546123
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IBA57 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IBA57
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IBA57 (NM_001010867) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IBA57 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IBA57 |
Additional cDNA sequence: AK023911.1 6 DOTS entries: DT.100733224 DT.75100419 DT.91922644 DT.91731859 DT.40130573 DT.100826912 24/43 AceView cDNA sequences (see all 43): AL583557 CR615475 AI953035 BQ023080 AW978541 AA831498 BI820993 AI341184 BM048834 BC028052 AI038116 BQ023708 BF592160 BM549690 BI252345 CB240803 BU688568 BM549285 BU168166 BG697277 AW104050 BG421070 BX378102 AW044301
GeneLoc Exon Structure
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Expression
for IBA57 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IBA57 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See IBA57 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IBA57
SOURCE GeneReport for Unigene clusters: Hs.237017 Hs.636881
SABiosciences Custom PCR Arrays for IBA57
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IBA57
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IBA57 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IBA57 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IBA57 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IBA57 |
Orthologs
for IBA57 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for IBA57 gene from 8/21 species (see all 21) About this table
ENSEMBL Gene Tree for IBA57 (if available)
TreeFam Gene Tree for IBA57 (if available) |
Paralogs
for IBA57 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for IBA57 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IBA57 (228353429 - 228369958 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IBA57: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IBA57 |
|
Disorders
/ Diseases
for IBA57 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for IBA57 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IBA57 gene integrated from 9 sources:
(articles sorted by number of sources associating them with IBA57) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The human mitochondrial ISCA1, ISCA2, and IBA57 protei ns are required for [4Fe-4S] protein maturation. (PubMed id 22323289)1 Sheftel A.D....Lill R. (2012)
- MINOS1 is a conserved component of mitofilin complexe s and required for mitochondrial function and cristae organization. (PubMed id 22114354)1 Alkhaja A.K....Deckers M. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Discovery of genes essential for heme biosynthesis th rough large-scale gene expression analysis. (PubMed id 19656490)1 Nilsson R....Mootha V.K. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
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External Searches for IBA57 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing IBA57 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IBA57 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IBA57 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IBA57 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for IBA57 gene:
Search GeneIP for patents involving IBA57
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IBA57 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for IBA57 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IBA57 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IBA57 | | | OriGene Protein Over-expression Lysate for IBA57 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IBA57 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IBA57 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IBA57 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | Search Tocris compounds for IBA57 |
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 | | | IBA57 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IBA57 |
|  |  |  | | | | ThermoFisher Antibody for IBA57 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IBA57 |
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