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Aliases & Descriptions for IARS2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 6.1.1.5 3 | | FLJ10326 1, 2 | | ILERS 2 | | IleRS 3 |
| | | Descriptions |
|---|
| Isoleucine--tRNA ligase 3 | | isoleucine tRNA ligase 2, mitochondrial 2 | | isoleucine-tRNA synthetase 2, mitochondrial 2 | | isoleucyl-tRNA synthetase 2, mitochondrial 2 | | mitochondrial isoleucine tRNA synthetase 2 |
|
| | Search outside databases for aliases for IARS2 genePrevious GC identifer: GC01P216656 |
Summaries for IARS2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| -- |
Genomic Location for IARS2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the IARS2 gene 
Entrez Gene cytogenetic band: 1q41 Ensembl cytogenetic band: 1q41 HGNC cytogenetic band: 1q41IARS2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P218334:
(about GC identifiers)
Start:
|
218,334,067 bp from pter |
End:
|
218,388,006 bp from pter |
Size:
|
53,940 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000001.9 NT_021877.18
| Proteins for IARS2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SYIM_HUMAN, Q9NSE4 (See
protein sequence)Recommended Name: Isoleucyl-tRNA synthetase, mitochondrial precursor Size: 1012 amino acids; 113792 Da
Subcellular location: Mitochondrion matrix (By similarity)
Sequence caution: Sequence=BAA91544.1; Type=Frameshift; Positions=879;
Secondary accessions: Q1M2P9 Q6PI85 Q7L439 Q86WU9 Q96D91 Q9H9Q8 Q9NW42Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_060530.3
ENSEMBL proteins: ENSP00000303279 ENSP00000355889
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for IARS2: Assays for IARS2: | Protein
Domains/ Families for IARS2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9NSE4
ProtoNet protein and cluster: Q9NSE4 2 Blocks protein families: IPB002300 Aminoacyl-tRNA synthetase IPB002301 Isoleucyl-tRNA synthetase signature
UniProtKB/Swiss-Prot: SYIM_HUMAN, Q9NSE4Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family | Gene Function for IARS2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018060
Applied Biosystems Silencer® siRNAs for IARS2
Sigma-Aldrich siRNA for IARS2  Sigma-Aldrich shRNA for IARS2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018060                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018060                                  untagged cDNA clones in CMV expression vector (see all 2): D28500 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_018060
UniProtKB/Swiss-Prot: SYIM_HUMAN, Q9NSE4Catalytic activity: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)Enzyme Number (IUBMB): EC 6.1.1.5 4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for IARS2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for IARS2 (Your Favorite Gene powered by Ingenuity) 
4 Interacting proteins for IARS2 (ENSP000003032793) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006428 | isoleucyl-tRNA aminoacylation |
IEA | -- | About this table
|
Drugs & Compounds for IARS2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for IARS2
|
Transcripts for IARS2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018060
Sigma-Aldrich siRNA for IARS2  Sigma-Aldrich shRNA for IARS2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_018060 REFSEQ mRNAs for IARS2 gene: NM_018060.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_018060               OriGene GFP tagged cDNA clone in CMV expression vector: NM_018060                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018060                                  untagged cDNA clones in CMV expression vector (see all 2): D28500  Additional cDNA sequence: AK001188.1 AK001726.1 AK022665.1 AK291432.1 AY267462.1 AY952883.1 BC010218.1 BC040376.1 BC047880.1 BC137438.1 CR606160.1 CR621413.1 CR622315.1 D28500.1 17 DOTS entries: DT.99934757 DT.121336558 DT.95214751 DT.453718 DT.92444800 DT.121336545 DT.75150403 DT.95214749 DT.97854650 DT.100822365 DT.121336583 DT.121336617 DT.92444799 DT.95214813 DT.95214815 DT.99966773 DT.91910585 24/291 AceView cDNA sequences (see all 291
):BF981431 BM827798 AI636307 AK022665 AA962169 AI469501 AA437174 BG283854 AI915924 AU118659 AW268711 AK001726 AU132576 BE220678 AW188441 AA805660 BG620018 AU132991 BE440113 CR622315 CB306960 AI863816 AI220196 AW167114
highest scoring ESTs for IARS2:AA526812 AA042812 AA094477 AA232722 AA236516 AA426442 AA523339 AA523446 AA523691 AA548731 Unigene Cluster for IARS2: Isoleucyl-tRNA synthetase 2, mitochondrial Hs.262823 [show with all ESTs]Unigene Representative Sequence: AY267462
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000302637
ENST00000366922
|
Expression for IARS2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| IARS2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for IARS2
1 / 2 / 3 4 probe-sets matching IARS2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CAGAAATATA
SOURCE GeneReport for Unigene cluster: Hs.262823
Expression variation in blood from EXPOLDB for IARS2 |
Orthologs for IARS2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for IARS2 gene from 5/20 species (see all 20
)
About this table Species with no ortholog for IARS2
ENSEMBL Gene Tree for IARS2 | Paralogs for IARS2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for IARS2 gene
- VARS2 IARS2 VARS22
|
SNPs/Variants for IARS2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for IARS2 (up to first 250kb)
|
Disorders & Mutations for IARS2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 612801
Human Genome Epidemiology Navigator: IARS2 (1 document)
|
Medical News for IARS2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for IARS2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 7 PubMed articles for IARS2 gene:- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)3, 4 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study. (PubMed id 19209188)3 Reiling E....Dekker J.M. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )4 Aoki H.... Hino O. (2000)
|
Search for IARS2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing IARS2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing IARS2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IARS2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for IARS2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for IARS2:

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Incremental update: 13 Oct 2009
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