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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IARS2 Gene

protein-coding   GIFtS: 59
GCID: GC01P220267

isoleucyl-tRNA synthetase 2, mitochondrial

 Explore 3 diseases affiliated with
IARS2 via our new
 Human Malady Compendium 
Biological research products
for IARS2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Isoleucyl-TRNA Synthetase 2, Mitochondrial1 2     Isoleucine-TRNA Synthetase 2, Mitochondrial2
EC 6.1.1.53 8     Isoleucyl-TRNA Synthetase, Mitochondrial2
FLJ103261     Mitochondrial Isoleucine TRNA Synthetase2
ILERS2     IleRS3
Isoleucine TRNA Ligase 2, Mitochondrial2     Isoleucyl-TRNA Synthetase3
Isoleucine--TRNA Ligase, Mitochondrial2     EC 6.1.18

External Ids:    HGNC: 296851   Entrez Gene: 556992   Ensembl: ENSG000000677047   OMIM: 6128015   UniProtKB: Q9NSE43   

Export aliases for IARS2 gene to outside databases

Previous GC identifers: GC01P216656 GC01P218334 GC01P190941


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IARS2 gene promoter:
         FOXD3   Ik-3   GATA-2   Arnt   GATA-1   HEN1   CBF-A   FOXJ2 (long isoform)   FOXJ2   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIARS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for IARS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IARS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41   Ensembl cytogenetic band:  1q41   HGNC cytogenetic band: 1q41

IARS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IARS2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P220267:  view genomic region     (about GC identifiers)

Start:
220,267,444 bp from pter      End:
220,321,383 bp from pter
Size:
53,940 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SYIM_HUMAN, Q9NSE4 (See protein sequence)
Recommended Name: Isoleucine--tRNA ligase, mitochondrial precursor  
Size: 1012 amino acids; 113792 Da
Subcellular location: Mitochondrion matrix (By similarity)
Sequence caution: Sequence=BAA91544.1; Type=Frameshift; Positions=879; Sequence=BAB14164.1; Type=Erroneous initiation;
Secondary accessions: B2RPG8 Q1M2P9 Q6PI85 Q7L439 Q86WU9 Q96D91 Q9H9Q8 Q9NW42

Explore the universe of human proteins at neXtProt for IARS2: NX_Q9NSE4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NSE4

  • 4/24 DME Specific Peptides for IARS2 (Q9NSE4) (see all 24)
     SLLTSVA  GHALNKI  YPYDWRT  SRQRVWG 

    IARS2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060530.3  
    ENSEMBL proteins: 
     ENSP00000355889   ENSP00000303279  
    Reactome Protein details: Q9NSE4
    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IARS2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--
    GO:0005759mitochondrial matrix TAS--


    IARS2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    IARS2 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR010663 Znf_DNA_glyclase/IsotRNA_synth
     IPR013155 V/L/I-tRNA-synth_anticodon-bd
     IPR002300 aa-tRNA-synth_Ia
     IPR023585 Ile-tRNA-ligase_type1
     IPR001412 aa-tRNA-synth_I_CS

    Graphical View of Domain Structure for InterPro Entry Q9NSE4

    ProtoNet protein and cluster: Q9NSE4

    2 Blocks protein families:
    IPB002300 Aminoacyl-tRNA synthetase
    IPB002301 Isoleucyl-tRNA synthetase signature


    UniProtKB/Swiss-Prot: SYIM_HUMAN, Q9NSE4
    Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SYIM_HUMAN, Q9NSE4
    Catalytic activity: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)

    Enzyme Numbers (IUBMB): EC 6.1.1.51 2 EC 6.1.12

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IARS2
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate IARS2:
    hsa-miR-3163 hsa-miR-532-5p hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidIARS2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IARS2 (see all 7)
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IARS2

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002161aminoacyl-tRNA editing activity IEA--
    GO:0004822isoleucine-tRNA ligase activity IEA--
    GO:0005524ATP binding IEA--


    IARS2 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for IARS2:
     Decreased viability  Increased viability after born  Synthetic lethal with Ras 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1tRNA Aminoacylation
    tRNA Aminoacylation1.00
    Mitochondrial tRNA aminoacylation0.50
    Aminoacyl-tRNA biosynthesis0.54
    2Valine, leucine and isoleucine biosynthesis
    Valine, leucine and isoleucine biosynthesis1.00
    3Generic Transcription Pathway
    Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for IARS2
        tRNA Aminoacylation
    Gene Expression
    Mitochondrial tRNA aminoacylation


    2         Kegg Pathways  (Kegg details for IARS2):
        Valine, leucine and isoleucine biosynthesis
    Aminoacyl-tRNA biosynthesis


    IARS2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IARS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/26 Interacting proteins for IARS2 (Q9NSE42, 3 ENSP000003032794) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSP90AB1P082382, 3MINT-72670 I2D: score=3 
    CALM1P621583I2D: score=1 
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    HLA-BP304803, ENSP000003991684I2D: score=1 STRING: ENSP00000399168
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006428isoleucyl-tRNA aminoacylation IEA--
    GO:0010467gene expression TAS--


    IARS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IARS2

    5 HMDB Compounds for IARS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Isoleucine(2S,3S)-2-Amino-3-methylpentanoate (see all 33)73-32-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for IARS2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Isoleucine(2S,3S)-2-Amino-3-methylpentanoic acid (see all 11)73-32-5target--15663927 16697013 14672940 17095543 12783542

    Search CenterWatch for drugs/clinical trials and news about IARS2 / SYIM 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IARS2 gene: 
    NM_018060.3  

    Unigene Cluster for IARS2:

    Isoleucyl-tRNA synthetase 2, mitochondrial
    Hs.262823  [show with all ESTs]
    Unigene Representative Sequence: AY267462
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366922(uc001hmc.3) ENST00000490891 ENST00000488777 ENST00000467924
    ENST00000302637

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate IARS2:
    hsa-miR-3163 hsa-miR-532-5p hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidIARS2 3' UTR sequence
    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IARS2
    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IARS2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IARS2

    Additional cDNA sequence: 

    AK001188.1 AK001726.1 AK022665.1 AK291432.1 AY267462.1 AY952883.1 BC010218.1 BC040376.1 
    BC047880.1 BC137438.1 D28500.1 

    18 DOTS entries:

    DT.99934757  DT.121336558  DT.95214751  DT.453718  DT.92444800  DT.121336545  DT.75150403  DT.95214749 
    DT.97854650  DT.100822365  DT.121336583  DT.121336617  DT.92444799  DT.95214813  DT.95214815  DT.99966773 
    DT.418095  DT.91910585 

    24/291 AceView cDNA sequences (see all 291):

    AA236516 AU132991 AI863816 BM700556 AI222446 CR622315 F05557 BI334634 
    BC047880 AA426442 CB159777 AI858947 AA704695 BG620018 AI220196 BM827798 
    AU118659 BG283854 AI636307 AW574815 AI372891 AI469501 BG740287 CR621413 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IARS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGAAATATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See IARS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IARS2

    SOURCE GeneReport for Unigene cluster: Hs.262823
        SABiosciences Custom PCR Arrays for IARS2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IARS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for IARS2 gene from 10/35 species (see all 35)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves IARS21 isoleucyl-tRNA synthetase 2, mitochondrial 73.83(n)
    72.42(a)
      421346  NM_001006397.1  NP_001006397.1 
    lizard
    (Anolis carolinensis)
    Reptilia IARS26
    --
    72(a)
    1 ↔ 1
    1(243279117-243316004)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1377244062   -- 80.85(n)    137724406 
    zebrafish
    (Danio rerio)
    Actinopterygii iars21 isoleucine-tRNA synthetase 2, mitochondrial 61.99(n)
    62.51(a)
      100001219  NM_001163798.1  NP_001157270.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG54141 CG5414 50.13(n)
    42.4(a)
      39762  NM_140580.2  NP_648837.2 
    worm
    (Caenorhabditis elegans)
    Secernentea iars-21 Protein IARS-2 46.37(n)
    36.31(a)
      172884  NM_001025836.2  NP_001021007.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ISM1(YPL040C)4
    ISM11
    Mitochondrial isoleucyl-tRNA synthetase, null mutant more4
    Ism1p1
    49.8(n)1
    40.4(a)1
      16(479001-475993)4
    8560671, 4  NP_015285.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons OVA21 isoleucyl-tRNA synthetase 50.61(n)
    43.61(a)
      834962  NM_001203568.1  NP_001190497.1 
    rice
    (Oryza sativa)
    Liliopsida AK065948.12   -- 74.2(n)    AK065948.1 
    E. coli
    (Escherichia coli)
    Gamma proteobacteria ileS6
    isoleucyl-tRNA synthetase
    36(a)
    1 ↔ 1
    Chromosome(22391-25207)


    ENSEMBL Gene Tree for IARS2 (if available)
    TreeFam Gene Tree for IARS2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IARS2 gene

    IARS2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IARS2
    PGOHUM00000249423


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/808 NCBI SNPs in IARS2 are shown (see all 808    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1867931041,2
    --220265541(+) AGCCCA/TGTTAT 1 -- us2k10--------
    rs789254571,2
    F,--220265597(+) TTTTAA/GCTGTC 1 -- us2k11Minor allele frequency- G:0.07WA 118
    rs788136701,2
    F,--220265600(+) TAACTG/CTCTAT 1 -- us2k11Minor allele frequency- C:0.07WA 118
    rs730965751,2
    C,F,--220265735(+) TTGCCC/TAGGCA 1 -- us2k15Minor allele frequency- T:0.08WA CSA NA EA 362
    rs1126657341,2
    --220265747(+) GAGTGC/TAGTGG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs730965771,2
    C,F,--220266155(+) TATGCA/GCACAC 1 -- us2k15Minor allele frequency- G:0.08WA CSA NA EA 362
    rs794982481,2
    --220266267(+) GAAATG/AGAAAT 1 -- us2k11Minor allele frequency- A:0.01EA 120
    rs1915822551,2
    --220266579(+) AACAAA/TTGTGA 1 -- us2k10--------
    rs1122886351,2
    --220266703(+) CTTAAG/AAAAAG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1864800721,2
    --220266738(+) AAAATA/CTATGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IARS2 (220267444 - 220321383 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for IARS2
         1 Indel: 44509

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IARS2
    DNA2.0 Custom Variant and Variant Library Synthesis for IARS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    IARS2 for disorders           About GeneDecksing

    OMIM gene information: 612801    OMIM disorders: --

    3 diseases for IARS2:    About MalaCards
    diabetes mellitus    cardiomyopathy    pneumonia

    Human Genome Epidemiology (HuGE) Navigator: IARS2 (2 documents)

    Export disorders for IARS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IARS2 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with IARS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    6. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55699 HGNC: 29685 AceView: FLJ10326 Ensembl:ENSG00000067704 euGenes: HUgn55699
    ECgene: IARS2 Kegg: 55699 H-InvDB: IARS2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IARS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IARS2 gene:
    Search GeneIP for patents involving IARS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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