IARS2 Gene
protein-coding GIFtS: 59
GCID: GC01P220267
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isoleucyl-tRNA synthetase 2, mitochondrial
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Aliases for IARS2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Isoleucyl-TRNA Synthetase 2, Mitochondrial1 2 | | Isoleucine-TRNA Synthetase 2, Mitochondrial2 | | EC 6.1.1.53 8 | | Isoleucyl-TRNA Synthetase, Mitochondrial2 | | FLJ103261 | | Mitochondrial Isoleucine TRNA Synthetase2 | | ILERS2 | | IleRS3 | | Isoleucine TRNA Ligase 2, Mitochondrial2 | | Isoleucyl-TRNA Synthetase3 | | Isoleucine--TRNA Ligase, Mitochondrial2 | | EC 6.1.18 |
Export aliases for IARS2 gene to outside databasesPrevious GC identifers: GC01P216656 GC01P218334 GC01P190941 |
Summaries for IARS2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| -- |
Genomic Views for IARS2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the IARS2 gene promoter: FOXD3 Ik-3 GATA-2 Arnt GATA-1 HEN1 CBF-A FOXJ2 (long isoform) FOXJ2 CBF(2) Other transcription factors
Search SABiosciences Chromatin IP Primers for IARS2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IARS2 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q41 Ensembl cytogenetic band: 1q41 HGNC cytogenetic band: 1q41IARS2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P220267: view genomic region
(about GC identifiers)
Start:
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220,267,444 bp from pter |
End:
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220,321,383 bp from pter |
Size:
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53,940 bases |
Orientation:
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plus strand |
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Proteins for IARS2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: SYIM_HUMAN, Q9NSE4 (See
protein sequence)Recommended Name: Isoleucine--tRNA ligase, mitochondrial precursor Size: 1012 amino acids; 113792 Da
Subcellular location: Mitochondrion matrix (By similarity)
Sequence caution: Sequence=BAA91544.1; Type=Frameshift; Positions=879; Sequence=BAB14164.1; Type=Erroneous initiation;
Secondary accessions: B2RPG8 Q1M2P9 Q6PI85 Q7L439 Q86WU9 Q96D91 Q9H9Q8 Q9NW42Explore the universe of human proteins at neXtProt for IARS2: NX_Q9NSE4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NSE4 4/24 DME Specific Peptides for IARS2 (Q9NSE4) (see all 24)
IARS2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060530.3 ENSEMBL proteins: ENSP00000355889 ENSP00000303279 Reactome Protein details: Q9NSE4 Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
IARS2 for ontologies About GeneDecksing
IARS2 Antibody Products: Assay Products for IARS2: |
Protein
Domains / Families for IARS2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IARS2 for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry Q9NSE4ProtoNet protein and cluster: Q9NSE4 2 Blocks protein families: IPB002300 Aminoacyl-tRNA synthetase IPB002301 Isoleucyl-tRNA synthetase signature
UniProtKB/Swiss-Prot: SYIM_HUMAN, Q9NSE4Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family |
Function for IARS2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: SYIM_HUMAN, Q9NSE4Catalytic activity: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)Enzyme Numbers (IUBMB): EC 6.1.1.51 2 EC 6.1.12
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IARS2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IARS2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IARS2 (NM_018060) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IARS2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IARS2  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IARS2 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002161 | aminoacyl-tRNA editing activity |
IEA | -- | | GO:0004822 | isoleucine-tRNA ligase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- |
IARS2 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for IARS2:
|
Pathways & Interactions for IARS2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | tRNA Aminoacylation | | | 2 | Valine, leucine and isoleucine biosynthesis | | | 3 | Generic Transcription Pathway | |
Pathway sources See GeneCards unified pathways Show all pathways
3
Reactome Pathways for IARS2
2
Kegg Pathways (Kegg details for IARS2):
IARS2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IARS2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
 5/26 Interacting proteins for IARS2 (Q9NSE42, 3 ENSP000003032794) via UniProtKB, MINT, STRING, and/or I2D (see all 26)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006418 | tRNA aminoacylation for protein translation |
TAS | -- | | GO:0006428 | isoleucyl-tRNA aminoacylation |
IEA | -- | | GO:0010467 | gene expression |
TAS | -- |
IARS2 for ontologies About GeneDecksing
|
Drugs & Compounds for IARS2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for IARS2
5 HMDB Compounds for IARS2 About this table
1 DrugBank Compound for IARS2 About this table
Search CenterWatch for drugs/clinical trials and news about IARS2 / SYIM 
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Transcripts for IARS2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for IARS2 gene: NM_018060.3 Unigene Cluster for IARS2: Isoleucyl-tRNA synthetase 2, mitochondrial Hs.262823 [show with all ESTs]Unigene Representative Sequence: AY2674625 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000366922(uc001hmc.3) ENST00000490891 ENST00000488777 ENST00000467924 ENST00000302637
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IARS2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IARS2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IARS2 (NM_018060) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IARS2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IARS2  |
Additional cDNA sequence: AK001188.1 AK001726.1 AK022665.1 AK291432.1 AY267462.1 AY952883.1 BC010218.1 BC040376.1 BC047880.1 BC137438.1 D28500.1 18 DOTS entries: DT.99934757 DT.121336558 DT.95214751 DT.453718 DT.92444800 DT.121336545 DT.75150403 DT.95214749 DT.97854650 DT.100822365 DT.121336583 DT.121336617 DT.92444799 DT.95214813 DT.95214815 DT.99966773 DT.418095 DT.91910585 24/291 AceView cDNA sequences (see all 291): AA236516 AU132991 AI863816 BM700556 AI222446 CR622315 F05557 BI334634 BC047880 AA426442 CB159777 AI858947 AA704695 BG620018 AI220196 BM827798 AU118659 BG283854 AI636307 AW574815 AI372891 AI469501 BG740287 CR621413 GeneLoc Exon Structure
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Expression for IARS2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IARS2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: CAGAAATATA
About this image See IARS2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for IARS2
SOURCE GeneReport for Unigene cluster: Hs.262823 SABiosciences Custom PCR Arrays for IARS2
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IARS2 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IARS2 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IARS2 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IARS2 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IARS2 |
Orthologs for IARS2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for IARS2 gene from 10/35 species (see all 35) About this table
ENSEMBL Gene Tree for IARS2 (if available) TreeFam Gene Tree for IARS2 (if available)  |
Paralogs for IARS2 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for IARS2 gene
IARS2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for IARS2 PGOHUM00000249423
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Genomic Variants for IARS2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 1 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for IARS2 (220267444 - 220321383 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for IARS2 1 Indel: 44509  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IARS2 |
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Disorders
/ Diseases for IARS2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IARS2 for disorders About GeneDecksing
OMIM gene information: 612801
OMIM disorders: --
3 diseases for IARS2: About MalaCardsdiabetes mellitus cardiomyopathy pneumonia Human Genome Epidemiology (HuGE) Navigator: IARS2 (2 documents) Export disorders for IARS2 gene to outside databases
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Publications for IARS2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IARS2 gene, integrated from 9 sources (see all 24): (articles sorted by number of sources associating them with IARS2) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
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External Searches for IARS2 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing IARS2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IARS2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IARS2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for IARS2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for IARS2 gene: Search GeneIP for patents involving IARS2
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for IARS2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for IARS2 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IARS2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IARS2 | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for IARS2 | | OriGene 3'-UTR Clone for IARS2 | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IARS2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IARS2 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for IARS2 | | OriGene Custom Protein Services for IARS2 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IARS2 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IARS2 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IARS2 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IARS2 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IARS2 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IARS2 |
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| | | Search Tocris compounds for IARS2 |
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 | | IARS2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IARS2 |
|  |  |  | | | ThermoFisher Antibodies for IARS2 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IARS2 |
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