Aliases for IARS Gene
External Ids for IARS Gene
Previous GeneCards Identifiers for IARS Gene
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012]
GeneCards Summary for IARS Gene
IARS (Isoleucyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with IARS include polymyositis and dermatomyositis. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include aminoacyl-tRNA editing activity and isoleucine-tRNA ligase activity.