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IARS Gene

protein-coding GIFtS: 65

GC09M094012

isoleucyl-tRNA synthetase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 6.1.1.5 ^³
FLJ20736 ^²
IARS1 ^¹, ²
ILERS ^²
ILRS ^¹, ²
IRS ^², ³
IleRS ^³
PRO0785 ^²

Descriptions
Isoleucine--tRNA ligase ^³
isoleucine tRNA ligase 1, cytoplasmic ^²
isoleucine tRNA synthetase ^²
isoleucyl-tRNA synthetase ^²

External Ids
HGNC: 5330¹
Entrez Gene: 3376²
UniProtKB: P41252³
Ensembl: ENSG00000196305⁷

Search outside databases for aliases for IARS gene

Previous GC identifers: GC09M085799 GC09M086700 GC09M088271 GC09M090314 GC09M092052

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for IARS:

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because

of their central role in linking amino acids with nucleotide triplets contained in tRNAS,

aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution.

Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been

identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis.

Two alternatively spliced variants have been isolated that represent alternate 5' UTRs.

[provided by RefSeq]

Gene Wiki entry for IARS

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the IARS gene

Entrez Gene cytogenetic band: 9q21 Ensembl cytogenetic band: 9q22.31 HGNC cytogenetic band: 9q21

IARS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M094012: (about GC identifiers)

Start:	94,012,446 bp from pter
End:	94,095,859 bp from pter
Size:	83,414 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_008470.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SYIC_HUMAN, P41252 (See protein sequence)

Recommended Name: Isoleucyl-tRNA synthetase, cytoplasmic

Size: 1262 amino acids; 144498 Da

Subunit: Part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu,

Lys, Met and Pro

Subcellular location: Cytoplasm

Secondary accessions: A8KAE9 Q5TCD0 Q7Z3T4 Q9H588

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_002152.2 NP_038203.2

ENSEMBL proteins:

ENSP00000364778 ENSP00000364780 ENSP00000378922 ENSP00000364783 ENSP00000364794 ENSP00000364811

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Isoleucyl tRNA synthetase)
	Human Recombinant Proteins from Abnova (IARS)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	TAS	7721108
GO:0005737	cytoplasm	TAS	7721108

About this table

Antibodies for IARS:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for IARS
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Isoleucyl tRNA synthetase), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (IARS)
	Novus Biologicals Antibodies for IARS

Assays for IARS:

	Invitrogen Assays for IARS
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P41252

ProtoNet protein and cluster: P41252

3 Blocks protein families:

IPB002300 Aminoacyl-tRNA synthetase

IPB002301 Isoleucyl-tRNA synthetase signature

IPB013155 tRNA synthetase

UniProtKB/Swiss-Prot: SYIC_HUMAN, P41252

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IARS)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_013417

Applied Biosystems Silencer® siRNAs for IARS

Sigma-Aldrich siRNA for IARS

Sigma-Aldrich shRNA for IARS

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for IARS
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002161
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002161
untagged cDNA clones in CMV expression vector (see all 2): NM_002161

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_013417

UniProtKB/Swiss-Prot: SYIC_HUMAN, P41252

Catalytic activity: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)

Enzyme Number (IUBMB): EC 6.1.1.5

Genatlas biochemistry entry for IARS:

isoleucyl-tRNA synthetase,target of autoantibodies in the autoimmune disease

polymyositis/dermatomyositis

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004822	isoleucine-tRNA ligase activity	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0016874	ligase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for IARS (Your Favorite Gene powered by Ingenuity)

Valine, Leucine and Isoleucine Biosynthesis
Aminoacyl-tRNA Biosynthesis

GeneDecks IARS for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for IARS

5/25 Interacting proteins for IARS (ENSP00000364811³ P41252²) via UniProtKB, MINT, and/or STRING (see all 25 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
EPRS	P07814²	STRING (score=.992) MINT-15365 MINT-15364
NFKB2	Q00653²	MINT-48578 MINT-48712
IKBKG	Q9Y6K9²	MINT-48159
MAP3K14	Q99558²	MINT-48808
MAP3K3	Q99759²	MINT-48408

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006428	isoleucyl-tRNA aminoacylation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IARS
4 Novoseek chemical compound relationships for IARS gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
aminoacyl-trna	82.48	2	7721108 (1)
trna	78.13	11	14596614 (2), 10913161 (2), 8052601 (1), 9548745 (1) (see all 8)
isoleucine	69.17	3	9548745 (1), 10066735 (1), 8692688 (1)
atp	28.06	1	10821672 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (IARS)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_013417

Sigma-Aldrich siRNA for IARS

Sigma-Aldrich shRNA for IARS

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002161 NM_013417

REFSEQ mRNAs for IARS gene (2 alternative transcripts):

NM_002161.4 NM_013417.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002161 NM_013417

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002161
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002161
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002161

Additional cDNA sequence:

AB209234.1 AF113680.1 AK057920.1 AK123909.1 AK127087.1 AK293014.1 AK301272.1 AK308202.1

BC008318.1 BC065552.1 BX537417.1 BX537429.1 BX538109.1 BX647071.1 BX647236.1 BX647430.1

BX648567.1 CR608663.1 D28473.1 U04953.1

24/39 DOTS entries (see all 39 ):

DT.100886659 DT.91764782 DT.100011116 DT.91852124 DT.91930461 DT.455504 DT.95278997 DT.101985387

DT.92398647 DT.92031077 DT.87008011 DT.121158091 DT.91967980 DT.95278994 DT.95278999 DT.100886653

DT.100886662 DT.304867 DT.91764781 DT.92337040 DT.100687050 DT.100886661 DT.100886664 DT.121158034

1 AceView cDNA sequence:

CB045335

highest scoring ESTs for IARS:

U04953 AL602153 AL602230 AU133063 AU134475 AU140501 AU142845 BE885577 BG106039 BG176735

Unigene Cluster for IARS:

Isoleucyl-tRNA synthetase

Hs.445403 [show with all ESTs]

Unigene Representative Sequence: NM_013417

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for IARS (see all 10 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21a	·
SP1:					-												-																																-
SP2:																	-																																-
SP3:													-				-																																-
SP4:					-				-								-																																-
SP5:

ExUns:	21b	^	22a	·	22b	^	23a	·	23b	^	24a	·	24b	^	25	^	26a	·	26b	^	27	^	28	^	29	^	30	^	31	^	32a	·	32b	^	33a	·	33b	^	34	^	35	^	36a	·	36b
SP1:	-		-				-				-																														-
SP2:	-		-				-				-																														-
SP3:	-		-				-				-																						-		-						-
SP4:	-		-				-				-																														-
SP5:

About this scheme

ECgene alternative splicing isoforms for IARS

6 Ensembl transcripts including schematic representations:

ENST00000375627 ENST00000375629 ENST00000395554 ENST00000375632 ENST00000375643 ENST00000375660

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IARS expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IARS

¹ / ² / ³

3 probe-sets matching IARS gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40827_at²^{, 3}	U95-A	1	0.88	1.00	1.00	1.00	U04953	1.00	1.00	1.00	1
204744_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_013417	0.60	1.00	0.82	1
204744_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTGGGAGCAG

SOURCE GeneReport for Unigene cluster: Hs.445403
Expression variation in blood from EXPOLDB for IARS

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IARS gene from 5/21 species (see all 21 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IARS¹	--	isoleucyl-tRNA synthetase	85.82(n) 88.49(a)	484216 XM_541332.2 XP_541332.2
chimpanzee (Pan troglodytes)	IARS¹	--	isoleucyl-tRNA synthetase	99.62(n) 99.48(a)	465229 XM_520691.2 XP_520691.2
cow (Bos taurus)	IARS¹	--	isoleucyl-tRNA synthetase	89.78(n) 91.13(a)	509885 XM_866343.2 XP_871436.1
rat (Rattus norvegicus)	Iars¹	--	isoleucyl-tRNA synthetase	85.62(n) 90.8(a)	306804 XM_225196.4 XP_225196.4
mouse (Mus musculus)	Iars^{1, 5}	13⁵	isoleucine-tRNA synthetase^{1, 5}	85.8(n)¹ 90.64(a)¹	105148¹ NM_172015.2¹ NP_742012.1¹ AA009281⁵ AI327140⁵ (see all 15)

About this table Species with no ortholog for IARS

ENSEMBL Gene Tree for IARS

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for IARS gene

VARS² IARS2² VARS2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/399 NCBI SNPs in IARS are shown (see all 399 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 112)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1058751^1,2	A,C,F,H,O	94012737(-)	`TTGAGA/TCCTCA`	2	--	ut3¹		8		MN NA EU EA WA	744
	rs556155^1,2	A,C,F,H,O	94025458(+)	`TGGCTT/CTGCAT`	2	E/K	mis¹ ese³		17		EA NA MN EU WA	2784
--	rs1058726^1,2	A,C,F,H	94012787(-)	`AAATAT/CGCTGC`	2	--	ut3¹ ese³		8		MN NA EU EA WA	744
	rs6651532^1,2	A,C,F,H	94012305(+)	`TCACCC/TGGGAT`	2	--	ng5¹		7		EU EA WA NA	560
	rs10992297^1,2	C,F,H	94097283(+)	`AGTACT/CGTTGT`	2	--	ng3¹ tfbs³		8		EU EA WA	834
	rs3758230^1,2	C,F,H	94096267(-)	`GAAGCG/AGCTTT`	2	--	ng3¹		5		EA EU WA	1882
--	rs6479412^1,2	A,C	94012218(+)	`ccgttC/Tatcct`	2	--	ng5¹		0	--	--	--	--
--	rs12004004^1,2	C	94096052(+)	`TAGACC/TGAGGT`	2	--	ng3¹		0	--	--	--	--
	rs3758231^1,2	C	94096017(-)	`CACGCA/CCAGCG`	2	--	ng3¹		0	--	--	--	--
	rs10992272^1,2	H	94012101(+)	`tcttaG/Tagttg`	2	--	ng5¹		4		EU EA WA	420

About this table

HapMap Linkage Disequilibrium images for IARS (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600709

(Possibly Related Articles in Doctor's Guide)
About This Section

IARS: Limb Amputations Carry High Mortality Risk in Cardiac Patients

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/31 PubMed articles for IARS gene (see all 31 ):

Human isoleucyl-tRNA synthetase: sequence of the cDNA, alternative mRNA splicing, and the characteristics of an unusually long C-terminal extension. (PubMed id 7721108)^{1, 3, 4} Nichols R.C.... Plotz P.H. (1995)
Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence of the anticodon-binding domain and acquisition of a new structural unit. (PubMed id 8052601)^{1, 3, 4} Shiba K.... Noda T. (1994)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{3, 4} Humphray S.J.... Dunham I. (2004)
Assignment of two human autoantigen genes-isoleucyl-tRNA synthetase locates to 9q21 and lysyl-tRNA synthetase locates to 16q23-q24. (PubMed id 8812440)^{2, 3} Nichols R.C....Liu P. (1996)
Interaction between human tRNA synthetases involves repeated sequence elements. (PubMed id 8816763)^{1, 3} Rho S.B....Kim S. (1996)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS Spectra. (PubMed id 17924679)⁴ Yu L.-R.... Veenstra T.D. (2007)
Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)³ Ewing R.M....Figeys D. (2007)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3376	HGNC: 5330	AceView: IARS.2	Ensembl:ENSG00000196305	euGenes: HUgn3376
ECgene: IARS	H-InvDB: IARS

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for IARS
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IARS:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IARS-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IARS		Antibodies for IARS
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for IARS		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (IARS)
	Antibodies (IARS)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Isoleucyl tRNA synthetase)
	Antibodies (Isoleucyl tRNA synthetase)

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Search Tocris compounds for IARS

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for IARS

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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IARS Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for IARS

Summaries
for IARS

Genomic Location
for IARS

Proteins
for IARS

Protein Domains/
Families
for IARS

Gene Function
for IARS

Pathways & Interactions
for IARS

Drugs & Compounds
for IARS

Transcripts
for IARS

Expression
for IARS

Orthologs
for IARS

Paralogs
for IARS

SNPs/Variants
for IARS

Disorders & Mutations
for IARS

Medical News
for IARS

Publications
for IARS

Search for IARS

Genome Databases showing IARS

Other Databases showing IARS

Specialized Databases showing IARS

Licensable Technologies
for IARS

Services
for IARS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IARS Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor IARS

Summariesfor IARS

Genomic Locationfor IARS

Proteinsfor IARS

Protein Domains/Familiesfor IARS

Gene Functionfor IARS

Pathways & Interactionsfor IARS

Drugs & Compoundsfor IARS

Transcriptsfor IARS

Expression for IARS

Orthologsfor IARS

Paralogsfor IARS

SNPs/Variantsfor IARS

Disorders & Mutationsfor IARS

Medical Newsfor IARS

Publicationsfor IARS

Search for IARS

Genome Databases showing IARS

Other Databases showing IARS

Specialized Databases showing IARS

Licensable Technologiesfor IARS

Servicesfor IARS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IARS

Summaries
for IARS

Genomic Location
for IARS

Proteins
for IARS

Protein Domains/
Families
for IARS

Gene Function
for IARS

Pathways & Interactions
for IARS

Drugs & Compounds
for IARS

Transcripts
for IARS

Expression
for IARS

Orthologs
for IARS

Paralogs
for IARS

SNPs/Variants
for IARS

Disorders & Mutations
for IARS

Medical News
for IARS

Publications
for IARS

Licensable Technologies
for IARS

Services
for IARS