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Aliases for IARS Gene

Aliases for IARS Gene

  • Isoleucyl-TRNA Synthetase 4 2 3
  • EC 6.1.1.5 4 63
  • ILERS 3 4
  • IRS 3 4
  • Isoleucyl-TRNA Synthetase, Cytoplasmic 3
  • Isoleucine TRNA Ligase 1, Cytoplasmic 3
  • Isoleucine--TRNA Ligase, Cytoplasmic 3
  • Isoleucine TRNA Ligase 1 2
  • Cytoplasmic 2
  • EC 6.1.1 63
  • PRO0785 3
  • IARS1 3
  • ILRS 3

External Ids for IARS Gene

Previous GeneCards Identifiers for IARS Gene

  • GC09M085799
  • GC09M086700
  • GC09M088271
  • GC09M090314
  • GC09M092052
  • GC09M094012
  • GC09M094972
  • GC09M064650

Summaries for IARS Gene

Entrez Gene Summary for IARS Gene

  • Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012]

GeneCards Summary for IARS Gene

IARS (Isoleucyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with IARS include polymyositis and dermatomyositis. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include aminoacyl-tRNA editing activity and isoleucine-tRNA ligase activity.

Gene Wiki entry for IARS Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IARS Gene

Genomics for IARS Gene

Regulatory Elements for IARS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IARS Gene

Start:
92,210,207 bp from pter
End:
92,293,756 bp from pter
Size:
83,550 bases
Orientation:
Minus strand

Genomic View for IARS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IARS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IARS Gene

Proteins for IARS Gene

  • Protein details for IARS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41252-SYIC_HUMAN
    Recommended name:
    Isoleucine--tRNA ligase, cytoplasmic
    Protein Accession:
    P41252
    Secondary Accessions:
    • A8KAE9
    • Q5TCD0
    • Q7Z3T4
    • Q9H588

    Protein attributes for IARS Gene

    Size:
    1262 amino acids
    Molecular mass:
    144498 Da
    Quaternary structure:
    • Part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro
    SequenceCaution:
    • Sequence=BAA05835.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for IARS Gene

Proteomics data for IARS Gene at MOPED

Post-translational modifications for IARS Gene

  • Ubiquitination at Lys410, Lys450, Lys868, Lys917, and Lys1051
  • Modification sites at PhosphoSitePlus

Other Protein References for IARS Gene

Antibody Products

Domains for IARS Gene

Gene Families for IARS Gene

HGNC:
  • aaRS1 :Aminoacyl tRNA synthetases / Class I

Suggested Antigen Peptide Sequences for IARS Gene

Graphical View of Domain Structure for InterPro Entry

P41252

UniProtKB/Swiss-Prot:

SYIC_HUMAN :
  • P41252
Family:
  • Belongs to the class-I aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with IARS: view

Function for IARS Gene

Molecular function for IARS Gene

GENATLAS Biochemistry:
isoleucyl-tRNA synthetase,target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)

Enzyme Numbers (IUBMB) for IARS Gene

Gene Ontology (GO) - Molecular Function for IARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0002161 aminoacyl-tRNA editing activity IEA --
GO:0004812 aminoacyl-tRNA ligase activity --
GO:0004822 isoleucine-tRNA ligase activity TAS --
GO:0005515 protein binding IPI 10913161
genes like me logo Genes that share ontologies with IARS: view

Phenotypes for IARS Gene

GenomeRNAi human phenotypes for IARS:
genes like me logo Genes that share phenotypes with IARS: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IARS

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for IARS Gene

Localization for IARS Gene

Subcellular locations from UniProtKB/Swiss-Prot for IARS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IARS Gene COMPARTMENTS Subcellular localization image for IARS gene
Compartment Confidence
cytosol 4
nucleus 4
chloroplast 2
plasma membrane 2
cytoskeleton 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 16210410
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with IARS: view

Pathways for IARS Gene

genes like me logo Genes that share pathways with IARS: view

Pathways by source for IARS Gene

1 KEGG pathway for IARS Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for IARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IDA 16210410
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006428 isoleucyl-tRNA aminoacylation IBA --
GO:0006450 regulation of translational fidelity IEA --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with IARS: view

Compounds for IARS Gene

(1) ApexBio Compounds for IARS Gene

Compound Action Cas Number
Mupirocin [12650-69-0]

(5) HMDB Compounds for IARS Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
L-Isoleucine
  • (2S,3S)-2-Amino-3-methylpentanoate
73-32-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(1) Drugbank Compounds for IARS Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Isoleucine
  • (2S,3S)-2-Amino-3-methylpentanoic acid
73-32-5 target

(6) Novoseek inferred chemical compound relationships for IARS Gene

Compound -log(P) Hits PubMed IDs
mupirocin 85.5 10
aminoacyl-trna 82.8 1
trna 76.4 10
isoleucine 70.7 5
valine 48.8 2
genes like me logo Genes that share compounds with IARS: view

Transcripts for IARS Gene

mRNA/cDNA for IARS Gene

(16) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IARS Gene

Isoleucyl-tRNA synthetase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IARS

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IARS Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

ExUns: 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33a · 33b ^ 34 ^ 35 ^ 36a · 36b
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5:
SP6:
SP7:
SP8: -
SP9: -
SP10:

Relevant External Links for IARS Gene

GeneLoc Exon Structure for
IARS
ECgene alternative splicing isoforms for
IARS

Expression for IARS Gene

mRNA expression in normal human tissues for IARS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for IARS Gene

This gene is overexpressed in Lymph node (10.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IARS Gene

SOURCE GeneReport for Unigene cluster for IARS Gene Hs.445403

genes like me logo Genes that share expressions with IARS: view

Expression partners for IARS Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IARS Gene

Orthologs for IARS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IARS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IARS 35
  • 89.8 (n)
  • 91.13 (a)
IARS 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IARS 35
  • 87.43 (n)
  • 90.41 (a)
IARS 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Iars 35
  • 85.88 (n)
  • 90.72 (a)
Iars 16
Iars 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IARS 35
  • 99.66 (n)
  • 99.52 (a)
IARS 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Iars 35
  • 85.62 (n)
  • 90.8 (a)
oppossum
(Monodelphis domestica)
Mammalia IARS 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IARS 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves IARS 35
  • 76.26 (n)
  • 82.24 (a)
IARS 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IARS 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia iars 35
  • 71.56 (n)
  • 78.21 (a)
zebrafish
(Danio rerio)
Actinopterygii iars 35
  • 68.23 (n)
  • 74.76 (a)
wufi46h05 35
iars 36
  • 74 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6766 35
fruit fly
(Drosophila melanogaster)
Insecta Aats-ile 37
  • 59 (a)
Aats-ile 35
  • 57.03 (n)
  • 56.72 (a)
Aats-ile 36
  • 54 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002101 35
  • 56.44 (n)
  • 60.44 (a)
worm
(Caenorhabditis elegans)
Secernentea irs-1 37
  • 59 (a)
iars-1 35
  • 57.22 (n)
  • 57.73 (a)
iars-1 36
  • 56 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER394W 35
  • 56 (n)
  • 55.59 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20549g 35
  • 56.37 (n)
  • 54.52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ILS1 35
  • 55.56 (n)
  • 54.73 (a)
ILS1 36
  • 54 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G10320 35
  • 58.39 (n)
  • 55.99 (a)
rice
(Oryza sativa)
Liliopsida Os.8879 35
corn
(Zea mays)
Liliopsida Zm.12745 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03575 35
  • 54.86 (n)
  • 53.43 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes irs1 35
  • 56.12 (n)
  • 54.77 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
OneToOne
Species with no ortholog for IARS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IARS Gene

ENSEMBL:
Gene Tree for IARS (if available)
TreeFam:
Gene Tree for IARS (if available)

Paralogs for IARS Gene

Pseudogenes.org Pseudogenes for IARS Gene

genes like me logo Genes that share paralogs with IARS: view

No data available for Paralogs for IARS Gene

Variants for IARS Gene

Sequence variations from dbSNP and Humsavar for IARS Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs471478 -- 92,238,827(+) AACCT(C/T)GCTCC intron-variant
rs472163 -- 92,230,841(+) ctaac(A/G)gctaa intron-variant
rs501814 -- 92,221,868(+) GGCTA(C/T)TTTAC intron-variant
rs504708 -- 92,254,926(+) AATGC(A/G)CATCT intron-variant
rs544396 -- 92,234,058(+) gcctg(A/G)cctag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IARS Gene

Variant ID Type Subtype PubMed ID
nsv893573 CNV Gain 21882294
nsv6615 CNV Insertion 18451855

Relevant External Links for IARS Gene

HapMap Linkage Disequilibrium report
IARS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IARS Gene

Disorders for IARS Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for IARS Gene in MalaCards »

(2) Diseases for IARS Gene including...

Relevant External Links for IARS

Genetic Association Database (GAD)
IARS
Human Genome Epidemiology (HuGE) Navigator
IARS
genes like me logo Genes that share disorders with IARS: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for IARS Gene

Publications for IARS Gene

  1. Human isoleucyl-tRNA synthetase: sequence of the cDNA, alternative mRNA splicing, and the characteristics of an unusually long C-terminal extension. (PMID: 7721108) Nichols R.C. … Plotz P.H. (Gene 1995) 3 4 23
  2. Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence of the anticodon-binding domain and acquisition of a new structural unit. (PMID: 8052601) Shiba K. … Noda T. (Proc. Natl. Acad. Sci. U.S.A. 1994) 3 4 23
  3. Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases. (PMID: 10913161) Kang J. … Kim S. (J. Biol. Chem. 2000) 3 23
  4. Assignment of two human autoantigen genes-isoleucyl-tRNA synthetase locates to 9q21 and lysyl-tRNA synthetase locates to 16q23-q24. (PMID: 8812440) Nichols R.C. … Liu P. (Genomics 1996) 2 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for IARS Gene

Sources for IARS Gene

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