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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IARS Gene

protein-coding GIFtS: 62
GCID: GC09M094972

isoleucyl-tRNA synthetase

Explore 10 diseases affiliated with
IARS via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Isoleucyl-TRNA Synthetase¹ ² ³		PRO0785²
IARS1¹ ²		Isoleucine TRNA Ligase 1, Cytoplasmic²
ILRS¹ ²		Isoleucine--TRNA Ligase, Cytoplasmic²
IRS² ³		Isoleucyl-TRNA Synthetase, Cytoplasmic²
EC 6.1.1.5³ ⁸		IleRS³
ILERS²		EC 6.1.1⁸

External Ids:	HGNC: 5330¹	Entrez Gene: 3376²	Ensembl: ENSG00000196305⁷	OMIM: 600709⁵	UniProtKB: P41252³

Export aliases for IARS gene to outside databases

Previous GC identifers: GC09M085799 GC09M086700 GC09M088271 GC09M090314 GC09M092052 GC09M094012 GC09M064650

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IARS:

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central

role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be

among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA

synthetase family and has been identified as a target of autoantibodies in the autoimmune disease

polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. (provided by RefSeq, Nov

2012)

Gene Wiki entry for IARS

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IARS gene promoter:
AREB6 GATA-3 Pbx1a GATA-2 GATA-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IARS promoter sequence

Search SABiosciences Chromatin IP Primers for IARS

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IARS

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21 Ensembl cytogenetic band: 9q22.31 HGNC cytogenetic band: 9q21

IARS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IARS gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M094972: view genomic region (about GC identifiers)

Start:	94,972,489 bp from pter	End:	95,056,038 bp from pter
Size:	83,550 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SYIC_HUMAN, P41252 (See protein sequence)

Recommended Name: Isoleucine--tRNA ligase, cytoplasmic

Size: 1262 amino acids; 144498 Da

Subunit: Part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro

Subcellular location: Cytoplasm

Sequence caution: Sequence=BAA05835.1; Type=Erroneous initiation;

Secondary accessions: A8KAE9 Q5TCD0 Q7Z3T4 Q9H588

Explore the universe of human proteins at neXtProt for IARS: NX_P41252

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P41252

4/23 DME Specific Peptides for IARS (P41252) (see all 23)

YGADALR

WTTTPWT

YKAVPSW

DCWFESG

IARS Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_002152.2 NP_038203.2

ENSEMBL proteins:

ENSP00000364794 ENSP00000406483 ENSP00000407658 ENSP00000364778 ENSP00000407878

ENSP00000378922 ENSP00000387603 ENSP00000406448 ENSP00000415020 ENSP00000364780

Reactome Protein details: P41252
Human Recombinant Protein Products:

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	Novus Biologicals IARS Protein Novus Biologicals IARS Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for IARS

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005625	soluble fraction	--	--
GO:0005634	nucleus	IDA	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	TAS	--

IARS for ontologies About GeneDecksing

IARS Antibody Products:

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	Uscn Antibodies for IARS
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Assay Products for IARS:

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	Uscn ELISAs and CLIAs for IARS

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IARS for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR013155 V/L/I-tRNA-synth_anticodon-bd

IPR002300 aa-tRNA-synth_Ia

IPR001412 aa-tRNA-synth_I_CS

IPR023586 Ile-tRNA-ligase_type2

IPR002301 Ile-tRNA-ligase

Graphical View of Domain Structure for InterPro Entry P41252

ProtoNet protein and cluster: P41252

3 Blocks protein families:

IPB002300 Aminoacyl-tRNA synthetase

IPB002301 Isoleucyl-tRNA synthetase signature

IPB013155 tRNA synthetase

UniProtKB/Swiss-Prot: SYIC_HUMAN, P41252

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SYIC_HUMAN, P41252

Catalytic activity: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)

Genatlas biochemistry entry for IARS:

isoleucyl-tRNA synthetase,target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis

Enzyme Numbers (IUBMB): EC 6.1.1.5¹ ² EC 6.1.1²

miRNA Products:		OriGene 3'-UTR Clone (see all 2): IARS Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IARS
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate IARS:
		hsa-miR-217 hsa-miR-153 hsa-miR-29a*
		SwitchGear 3'UTR luciferase reporter plasmid: IARS 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IARS (see all 7) OriGene shRNA RFP: IARS OriGene siRNA: IARS
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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for IARS
		Search LifeMap BioReagents cell lines for IARS

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IARS

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002161	aminoacyl-tRNA editing activity	IEA	--
GO:0004812	aminoacyl-tRNA ligase activity	--	--
GO:0004822	isoleucine-tRNA ligase activity	TAS	--
GO:0005515	protein binding	IPI	9556618
GO:0005524	ATP binding	IEA	--

IARS for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for IARS:

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

tRNA Aminoacylation

	tRNA Aminoacylation	1.00			Aminoacyl-tRNA biosynthesis	0.54
	Cytosolic tRNA aminoacylation	0.57

Valine, leucine and isoleucine biosynthesis

Valine, leucine and isoleucine biosynthesis

1.00

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for IARS

	Cytosolic tRNA aminoacylation
	tRNA Aminoacylation
	Gene Expression

2 Kegg Pathways (Kegg details for IARS):

	Valine, leucine and isoleucine biosynthesis
	Aminoacyl-tRNA biosynthesis

IARS for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IARS

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/192 Interacting proteins for IARS (P41252^{1, 2, 3} ENSP00000364794⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 192)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NFKB2	Q00653²^,³	MINT-48578 MINT-48712 I2D: score=2
TANK	Q92844²^,³, ENSP00000259075⁴	MINT-48253 I2D: score=2 STRING: ENSP00000259075
MAP3K14	Q99558²^,³	MINT-48808 I2D: score=2
MAP3K3	Q99759²^,³	MINT-48408 I2D: score=2
EPRS	P07814¹^,²^,³, ENSP00000355890⁴	EBI-355303,EBI-355315 MINT-15365 MINT-15364 I2D: score=5 STRING: ENSP00000355890

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006418	tRNA aminoacylation for protein translation	TAS	--
GO:0006428	isoleucyl-tRNA aminoacylation	IEA	--
GO:0010467	gene expression	TAS	--

IARS for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IARS for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IARS

5 HMDB Compounds for IARS About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine monophosphate	5'-AMP (see all 28)	61-19-8	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
L-Isoleucine	(2S,3S)-2-Amino-3-methylpentanoate (see all 33)	73-32-5	--
Phosphoric acid	acide phosphorique (FRENCH) (see all 20)	7664-38-2	--
Pyrophosphate	(4-)Diphosphoric acid ion (see all 10)	14000-31-8	--

1 DrugBank Compound for IARS About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
L-Isoleucine	(2S,3S)-2-Amino-3-methylpentanoic acid (see all 11)	73-32-5	target	--	8146659 17139284 8129874 17016423 5111605

6 Novoseek chemical compound relationships for IARS gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mupirocin	85.5	22	20176977 (2), 10821672 (2), 12652905 (2), 8540693 (1) (see all 7)
aminoacyl-trna	82.8	2	7721108 (1)
trna	76.4	11	14596614 (2), 10913161 (2), 8052601 (1), 9548745 (1) (see all 8)
isoleucine	70.7	6	19557155 (2), 9548745 (1), 8692688 (1), 10066735 (1)
valine	48.8	3	10066735 (1), 19557155 (1)
atp	31.5	1	10821672 (1)

Search CenterWatch for drugs/clinical trials and news about IARS / SYIC

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IARS gene (2 alternative transcripts):

NM_002161.5 NM_013417.3

Unigene Cluster for IARS:

Isoleucyl-tRNA synthetase

Hs.445403 [show with all ESTs]

Unigene Representative Sequence: NM_013417

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000375643(uc004art.1) ENST00000421189 ENST00000436450 ENST00000375627

ENST00000474340 ENST00000473915 ENST00000449893 ENST00000467876 ENST00000472894

ENST00000395554 ENST00000498025 ENST00000490438 ENST00000430417 ENST00000443024(uc004aru.3 uc010mqr.2 uc010mqt.2)

ENST00000447699 ENST00000375629(uc004ars.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): IARS Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IARS
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate IARS:
		hsa-miR-217 hsa-miR-153 hsa-miR-29a*
		SwitchGear 3'UTR luciferase reporter plasmid: IARS 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IARS (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IARS (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Additional cDNA sequence:

AB209234.1 AK057920.1 AK293014.1 AK308202.1 BC008318.1 BC065552.1 BX537417.1 BX537429.1

BX538109.1 BX647071.1 BX647236.1 BX647430.1 BX648567.1 D28473.1 NR_073446.1 U04953.1

24/39 DOTS entries (see all 39):

DT.100886659 DT.91764782 DT.100011116 DT.91852124 DT.91930461 DT.455504 DT.95278997 DT.92398647

DT.92031077 DT.87008011 DT.101985387 DT.121158091 DT.95278994 DT.95278999 DT.100886653 DT.100886662

DT.304867 DT.91764781 DT.91967980 DT.92337040 DT.100687050 DT.100886661 DT.100886664 DT.121158034

1 AceView cDNA sequence:

CB045335

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for IARS (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21a	·
SP1:					-												-																																-
SP2:																	-																																-
SP3:													-				-																																-
SP4:					-				-								-																																-
SP5:

ExUns:	21b	^	22a	·	22b	^	23a	·	23b	^	24a	·	24b	^	25	^	26a	·	26b	^	27	^	28	^	29	^	30	^	31	^	32a	·	32b	^	33a	·	33b	^	34	^	35	^	36a	·	36b
SP1:	-		-				-				-																														-
SP2:	-		-				-				-																														-
SP3:	-		-				-				-																						-		-						-
SP4:	-		-				-				-																														-
SP5:

ECgene alternative splicing isoforms for IARS

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IARS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGGGAGCAG

About this image

IARS expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See IARS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IARS

SOURCE GeneReport for Unigene cluster: Hs.445403

SABiosciences Expression via Pathway-Focused PCR Array including IARS:

Amino Acid Metabolism II in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IARS

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IARS

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for IARS gene from 8/36 species (see all 36) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	IARS¹	isoleucyl-tRNA synthetase	76.21(n) 82.16(a)		415957 XM_414300.2 XP_414300.2
lizard (Anolis carolinensis)	Reptilia	IARS⁶	--	81(a)	1 ↔ 1	2(156389941-156497817)
zebrafish (Danio rerio)	Actinopterygii	wufi46h05²	wufi46h05	74.41(n)		334393 BC056826.1
fruit fly (Drosophila melanogaster)	Insecta	Aats-ile^{1 , 3}	isoleucyl-tRNA aminoacylation isoleucine-tRNA more³ Isoleucyl-tRNA synthetase¹	59(a)³ 57.44(n)¹ 57.59(a)¹		45785¹ NM_168952.3¹ NP_730716.1¹
worm (Caenorhabditis elegans)	Secernentea	irs-1³ iars-1¹	isoleucyl-tRNA synthetase³ Protein IARS-1¹	59(a)³ 57.94(n)¹ 59.42(a)¹		IV(10368790-10372654)³ 177926¹ NM_069513.3¹ NP_501914.1¹
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	ILS1¹	Ils1p	55.34(n) 54.48(a)		852202 NP_009477.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G10320¹	isoleucyl-tRNA synthetase	58.36(n) 55.99(a)		826624 NM_117100.3 NP_192770.2
rice (Oryza sativa)	Liliopsida	Os.8879²	Oryza sativa (japonica cultivar-group) cDNA clone0 more	73.51(n)		AK101482.1

ENSEMBL Gene Tree for IARS (if available)
TreeFam Gene Tree for IARS (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for IARS gene

2 SIMAP similar genes for IARS using alignment to 10 protein entries: SYIC_HUMAN (see all proteins):

DKFZp686L0869 DKFZp686L17145

IARS for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for IARS
PGOHUM00000236274 PGOHUM00000236711

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs144408790^1,2		--	94972139(+)	`GGCCAC/TGCTCC`	2	--	ds500¹		0	--	--	--	--
rs10992272^1,2	C,H	--	94972280(+)	`TCTTAG/TAGTTG`	2	--	ds500¹		4		NS EA	420
rs79590581^1,2	C,F,	--	94972350(+)	`CCACAC/ATGCAG`	2	--	ds500¹		1		WA	118
rs6479412^1,2	C,F,A,	--	94972397(+)	`ccgttT/Catcct`	2	--	ds500¹		8		NA WA CSA	250
rs181705261^1,2		--	94972456(+)	`TCATCG/TGCTTC`	2	--	ds500¹		0	--	--	--	--
rs6651532^1,2	C,F,A,H,	--	94972484(+)	`TCACCC/TGGGAT`	2	--	ds500¹		28		NS EA NA WA CSA	2498
rs187123938^1,2		--	94972604(+)	`GAGAAC/TGAATT`	2	--	ds500¹		0	--	--	--	--
rs148380707^1,2		--	94972682(+)	`AAATTA/GTCCAG`	2	--	ut3¹		0	--	--	--	--
rs190530483^1,2		--	94972891(+)	`CTAAGA/GTTAAG`	2	--	ut3¹		0	--	--	--	--
rs1058751^1,2	C,F,O,A,H,	--	94972916(-)	`TTGAGA/TCCTCA`	2	--	ut3¹		15		MN NA NS EA CSA WA	993

HapMap Linkage Disequilibrium report for IARS (94972489 - 95056038 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IARS: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IARS

DNA2.0 Custom Variant and Variant Library Synthesis for IARS

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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IARS for disorders           About GeneDecksing

OMIM gene information: 600709    OMIM disorders: --

10 diseases for IARS:    About MalaCards

polymyositis dermatomyositis donohue syndrome turcot syndrome

appendicitis colorectal cancer cardiomyopathy tuberculosis

malaria mycobacterium tuberculosis

Human Genome Epidemiology (HuGE) Navigator: IARS (2 documents)

Export disorders for IARS gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for IARS gene, integrated from 9 sources (see all 68):
(articles sorted by number of sources associating them with IARS)

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Human isoleucyl-tRNA synthetase: sequence of the cDNA, alternative mRNA splicing, and the characteristics of an unusually long C-terminal extension. (PubMed id 7721108)^{1, 2, 9} Nichols R.C.... Plotz P.H. (1995)
Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence of the anticodon-binding domain and acquisition of a new structural unit. (PubMed id 8052601)^{1, 2, 9} Shiba K.... Noda T. (1994)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
Assignment of two human autoantigen genes-isoleucyl-tRNA synthetase locates to 9q21 and lysyl-tRNA synthetase locates to 16q23-q24. (PubMed id 8812440)^{1, 3} Nichols R.C....Liu P. (1996)
Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases. (PubMed id 10913161)^{1, 9} Kang J....Kim S. (2000)
Evidence for distinct locations for metal binding sites in two closely related class I tRNA synthetases. (PubMed id 8129874)^{7, 9} Schimmel P....Schmidt E. (1993)
Interaction between human tRNA synthetases involves repeated sequence elements. (PubMed id 8816763)^{1, 9} Rho S.B....Kim S. (1996)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3376	HGNC: 5330	AceView: IARS.2	Ensembl:ENSG00000196305	euGenes: HUgn3376
ECgene: IARS	Kegg: 3376	H-InvDB: IARS

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for IARS	Pharmacogenomics, SNPs, Pathways

Intellectual Property for IARS gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for IARS gene:
Search GeneIP for patents involving IARS

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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