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Aliases for IARS Gene

Aliases for IARS Gene

  • Isoleucyl-TRNA Synthetase 2 3 4 5
  • Isoleucine TRNA Ligase 1, Cytoplasmic 2 3
  • EC 6.1.1.5 4 61
  • ILERS 3 4
  • IRS 3 4
  • Isoleucine--TRNA Ligase, Cytoplasmic 3
  • EC 6.1.1 61
  • PRO0785 3
  • GRIDHH 3
  • IARS1 3
  • ILRS 3

External Ids for IARS Gene

Previous GeneCards Identifiers for IARS Gene

  • GC09M085799
  • GC09M086700
  • GC09M088271
  • GC09M090314
  • GC09M092052
  • GC09M094012
  • GC09M094972
  • GC09M064650

Summaries for IARS Gene

Entrez Gene Summary for IARS Gene

  • Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012]

GeneCards Summary for IARS Gene

IARS (Isoleucyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with IARS include Growth Retardation, Intellectual Developmental Disorder, Hypotonia, And Hepatopathy and Polymyositis. Among its related pathways are Metabolism and tRNA Aminoacylation. GO annotations related to this gene include nucleotide binding and GTPase binding.

Gene Wiki entry for IARS Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IARS Gene

Genomics for IARS Gene

Regulatory Elements for IARS Gene

Enhancers for IARS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F092291 1.5 FANTOM5 ENCODE 0.8 -0.3 -261 5.1 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 NOL8 CENPP OGN SPTLC1 IPPK IARS
GH09F092323 1.2 ENCODE 0.3 -31.7 -31676 3.0 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 CENPP NOL8 ENSG00000236115 HSPE1P22 RPL21P82 RPL21P86 SNX18P2 LOC101927993 SPTLC1 ASPN
GH09F092297 0.4 ENCODE 0.8 -4.5 -4508 0.6 ZNF316 NOL8 CENPP IARS
GH09F092313 0.7 ENCODE 0.3 -19.8 -19771 0.7 SMARCE1 HDAC1 RNF2 ETV1 DPF2 ARID1B GATA2 SMARCA4 HDAC2 IKZF1 CENPP IARS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IARS on UCSC Golden Path with GeneCards custom track

Promoters for IARS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001308401 156 2001 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for IARS Gene

Chromosome:
9
Start:
92,210,207 bp from pter
End:
92,293,756 bp from pter
Size:
83,550 bases
Orientation:
Minus strand

Genomic View for IARS Gene

Genes around IARS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IARS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IARS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IARS Gene

Proteins for IARS Gene

  • Protein details for IARS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41252-SYIC_HUMAN
    Recommended name:
    Isoleucine--tRNA ligase, cytoplasmic
    Protein Accession:
    P41252
    Secondary Accessions:
    • A8KAE9
    • Q5TCD0
    • Q7Z3T4
    • Q9H588

    Protein attributes for IARS Gene

    Size:
    1262 amino acids
    Molecular mass:
    144498 Da
    Quaternary structure:
    • Part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro.
    SequenceCaution:
    • Sequence=BAA05835.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for IARS Gene

Selected DME Specific Peptides for IARS Gene

P41252:
  • GWDCHGLP
  • PVEYEIDK
  • YKAVPSW
  • DGPPFATGLPH
  • RGWFYTL
  • DQTRGWF
  • PADFIAEG
  • TPLSNFE
  • YGADALR
  • SGSMPYAQ
  • FYDGPPFA
  • WTTTPWT
  • SRNRYWGTPIP
  • HYPFENK
  • QTRGWFY
  • FMESVWWVF
  • DFDNDYKT
  • GWDCHGLPVE
  • LAGTIKD
  • DCWFESG
  • RRFGWDCHGLP
  • RYWGTPIP
  • DYKTLYP

Post-translational modifications for IARS Gene

  • Ubiquitination at Lys 410, Lys 450, and Lys 868
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for IARS

Domains & Families for IARS Gene

Gene Families for IARS Gene

Suggested Antigen Peptide Sequences for IARS Gene

Graphical View of Domain Structure for InterPro Entry

P41252

UniProtKB/Swiss-Prot:

SYIC_HUMAN :
  • Belongs to the class-I aminoacyl-tRNA synthetase family.
Family:
  • Belongs to the class-I aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with IARS: view

Function for IARS Gene

Molecular function for IARS Gene

GENATLAS Biochemistry:
isoleucyl-tRNA synthetase,target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).

Enzyme Numbers (IUBMB) for IARS Gene

Gene Ontology (GO) - Molecular Function for IARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IEA --
GO:0000166 nucleotide binding IEA --
GO:0002161 aminoacyl-tRNA editing activity IEA --
GO:0004812 aminoacyl-tRNA ligase activity IEA --
GO:0004822 isoleucine-tRNA ligase activity IEA,TAS --
genes like me logo Genes that share ontologies with IARS: view
genes like me logo Genes that share phenotypes with IARS: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IARS Gene

Localization for IARS Gene

Subcellular locations from UniProtKB/Swiss-Prot for IARS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IARS gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 3
plasma membrane 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 16210410
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with IARS: view

Pathways & Interactions for IARS Gene

genes like me logo Genes that share pathways with IARS: view

Pathways by source for IARS Gene

Gene Ontology (GO) - Biological Process for IARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IDA 16210410
GO:0006412 translation IEA --
GO:0006418 tRNA aminoacylation for protein translation IEA,TAS --
GO:0006428 isoleucyl-tRNA aminoacylation IEA,IBA --
GO:0006450 regulation of translational fidelity IEA --
genes like me logo Genes that share ontologies with IARS: view

No data available for SIGNOR curated interactions for IARS Gene

Drugs & Compounds for IARS Gene

(8) Drugs for IARS Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Isoleucine Approved Nutra Target 0
Mupirocin Approved, Investigational, Vet_approved Pharma 62
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for IARS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8

(1) ApexBio Compounds for IARS Gene

Compound Action Cas Number
Mupirocin 12650-69-0
genes like me logo Genes that share compounds with IARS: view

Transcripts for IARS Gene

mRNA/cDNA for IARS Gene

(2) REFSEQ mRNAs :
(16) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IARS Gene

Isoleucyl-tRNA synthetase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IARS Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

ExUns: 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33a · 33b ^ 34 ^ 35 ^ 36a · 36b
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5:
SP6:
SP7:
SP8: -
SP9: -
SP10:

Relevant External Links for IARS Gene

GeneLoc Exon Structure for
IARS
ECgene alternative splicing isoforms for
IARS

Expression for IARS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IARS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IARS Gene

This gene is overexpressed in Lymph node (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IARS Gene



Protein tissue co-expression partners for IARS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IARS Gene:

IARS

SOURCE GeneReport for Unigene cluster for IARS Gene:

Hs.445403
genes like me logo Genes that share expression patterns with IARS: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IARS Gene

Orthologs for IARS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IARS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IARS 34 35
  • 99.66 (n)
cow
(Bos Taurus)
Mammalia IARS 34 35
  • 89.8 (n)
dog
(Canis familiaris)
Mammalia IARS 34 35
  • 87.43 (n)
mouse
(Mus musculus)
Mammalia Iars 34 16 35
  • 85.88 (n)
rat
(Rattus norvegicus)
Mammalia Iars 34
  • 85.62 (n)
oppossum
(Monodelphis domestica)
Mammalia IARS 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IARS 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves IARS 34 35
  • 76.26 (n)
lizard
(Anolis carolinensis)
Reptilia IARS 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia iars 34
  • 71.56 (n)
zebrafish
(Danio rerio)
Actinopterygii iars 34 35
  • 68.23 (n)
wufi46h05 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6766 34
fruit fly
(Drosophila melanogaster)
Insecta Aats-ile 36 34 35
  • 57.03 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002101 34
  • 56.44 (n)
worm
(Caenorhabditis elegans)
Secernentea irs-1 36
  • 59 (a)
iars-1 34 35
  • 57.22 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20549g 34
  • 56.37 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER394W 34
  • 56 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ILS1 34 35
  • 55.56 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G10320 34
  • 58.39 (n)
rice
(Oryza sativa)
Liliopsida Os.8879 34
corn
(Zea mays)
Liliopsida Zm.12745 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 64 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes irs1 34
  • 56.12 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03575 34
  • 54.86 (n)
Species where no ortholog for IARS was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IARS Gene

ENSEMBL:
Gene Tree for IARS (if available)
TreeFam:
Gene Tree for IARS (if available)

Paralogs for IARS Gene

Pseudogenes.org Pseudogenes for IARS Gene

genes like me logo Genes that share paralogs with IARS: view

No data available for Paralogs for IARS Gene

Variants for IARS Gene

Sequence variations from dbSNP and Humsavar for IARS Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_077055 Growth retardation, intellectual developmental disorder, hypotonia, and hepatopathy (GRIDHH) [MIM:617093]
VAR_077056 Growth retardation, intellectual developmental disorder, hypotonia, and hepatopathy (GRIDHH) [MIM:617093]
VAR_077057 Growth retardation, intellectual developmental disorder, hypotonia, and hepatopathy (GRIDHH) [MIM:617093]
VAR_077058 Growth retardation, intellectual developmental disorder, hypotonia, and hepatopathy (GRIDHH) [MIM:617093]
rs764500338 Pathogenic 92,269,937(+) CACTC(A/G)CACAA nc-transcript-variant, reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for IARS Gene

Variant ID Type Subtype PubMed ID
esv3545129 CNV deletion 23714750
esv3621077 CNV loss 21293372
esv3891693 CNV gain 25118596
nsv1046733 CNV gain 25217958
nsv1145974 CNV duplication 26484159
nsv6615 CNV insertion 18451855

Variation tolerance for IARS Gene

Residual Variation Intolerance Score: 6.68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.82; 79.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IARS Gene

Human Gene Mutation Database (HGMD)
IARS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IARS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IARS Gene

Disorders for IARS Gene

MalaCards: The human disease database

(4) MalaCards diseases for IARS Gene - From: ClinVar, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
growth retardation, intellectual developmental disorder, hypotonia, and hepatopathy
  • gridhh
polymyositis
  • pm
dermatomyositis
  • amyopathic dermatomyositis
anus cancer
  • anal cancer
- elite association - COSMIC cancer census association via MalaCards
Search IARS in MalaCards View complete list of genes associated with diseases

Relevant External Links for IARS

Genetic Association Database (GAD)
IARS
Human Genome Epidemiology (HuGE) Navigator
IARS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IARS
genes like me logo Genes that share disorders with IARS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IARS Gene

Publications for IARS Gene

  1. Human isoleucyl-tRNA synthetase: sequence of the cDNA, alternative mRNA splicing, and the characteristics of an unusually long C-terminal extension. (PMID: 7721108) Nichols R.C. … Plotz P.H. (Gene 1995) 3 4 22 64
  2. Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence of the anticodon-binding domain and acquisition of a new structural unit. (PMID: 8052601) Shiba K. … Noda T. (Proc. Natl. Acad. Sci. U.S.A. 1994) 3 4 22 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64

Products for IARS Gene

Sources for IARS Gene

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