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Aliases for IARS Gene

Aliases for IARS Gene

  • Isoleucyl-TRNA Synthetase 2 3 4 5
  • EC 6.1.1.5 4 63
  • ILERS 3 4
  • IRS 3 4
  • Isoleucyl-TRNA Synthetase, Cytoplasmic 3
  • Isoleucine TRNA Ligase 1, Cytoplasmic 3
  • Isoleucine TRNA Ligase 1 2
  • Cytoplasmic 2
  • EC 6.1.1 63
  • PRO0785 3
  • IARS1 3
  • ILRS 3

External Ids for IARS Gene

Previous GeneCards Identifiers for IARS Gene

  • GC09M085799
  • GC09M086700
  • GC09M088271
  • GC09M090314
  • GC09M092052
  • GC09M094012
  • GC09M094972
  • GC09M064650

Summaries for IARS Gene

Entrez Gene Summary for IARS Gene

  • Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012]

GeneCards Summary for IARS Gene

IARS (Isoleucyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with IARS include dermatomyositis. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include nucleotide binding and GTPase binding.

Gene Wiki entry for IARS Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IARS Gene

Genomics for IARS Gene

Regulatory Elements for IARS Gene

Promoters for IARS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IARS on UCSC Golden Path with GeneCards custom track

Genomic Location for IARS Gene

Chromosome:
9
Start:
92,210,207 bp from pter
End:
92,293,756 bp from pter
Size:
83,550 bases
Orientation:
Minus strand

Genomic View for IARS Gene

Genes around IARS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IARS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IARS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IARS Gene

Proteins for IARS Gene

  • Protein details for IARS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41252-SYIC_HUMAN
    Recommended name:
    Isoleucine--tRNA ligase, cytoplasmic
    Protein Accession:
    P41252
    Secondary Accessions:
    • A8KAE9
    • Q5TCD0
    • Q7Z3T4
    • Q9H588

    Protein attributes for IARS Gene

    Size:
    1262 amino acids
    Molecular mass:
    144498 Da
    Quaternary structure:
    • Part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro.
    SequenceCaution:
    • Sequence=BAA05835.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for IARS Gene

Proteomics data for IARS Gene at MOPED

Post-translational modifications for IARS Gene

  • Ubiquitination at Lys 410, Lys 450, and Lys 868
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for IARS Gene

Gene Families for IARS Gene

Suggested Antigen Peptide Sequences for IARS Gene

Graphical View of Domain Structure for InterPro Entry

P41252

UniProtKB/Swiss-Prot:

SYIC_HUMAN :
  • Belongs to the class-I aminoacyl-tRNA synthetase family.
Family:
  • Belongs to the class-I aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with IARS: view

Function for IARS Gene

Molecular function for IARS Gene

GENATLAS Biochemistry:
isoleucyl-tRNA synthetase,target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).

Enzyme Numbers (IUBMB) for IARS Gene

Gene Ontology (GO) - Molecular Function for IARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002161 aminoacyl-tRNA editing activity IEA --
GO:0004812 aminoacyl-tRNA ligase activity IEA --
GO:0051020 GTPase binding IPI 24337748
genes like me logo Genes that share ontologies with IARS: view
genes like me logo Genes that share phenotypes with IARS: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IARS Gene

Localization for IARS Gene

Subcellular locations from UniProtKB/Swiss-Prot for IARS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IARS Gene COMPARTMENTS Subcellular localization image for IARS gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
chloroplast 2
plasma membrane 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with IARS: view

Pathways & Interactions for IARS Gene

genes like me logo Genes that share pathways with IARS: view

Pathways by source for IARS Gene

Gene Ontology (GO) - Biological Process for IARS Gene

None

No data available for SIGNOR curated interactions for IARS Gene

Drugs & Compounds for IARS Gene

(8) Drugs for IARS Gene - From: DrugBank, HMDB, Novoseek, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Isoleucine Approved Nutra Target 0
Mupirocin Approved, Investigational Pharma 59
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(3) Additional Compounds for IARS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with IARS: view

Transcripts for IARS Gene

mRNA/cDNA for IARS Gene

(2) REFSEQ mRNAs :
(16) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IARS Gene

Isoleucyl-tRNA synthetase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IARS Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

ExUns: 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33a · 33b ^ 34 ^ 35 ^ 36a · 36b
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5:
SP6:
SP7:
SP8: -
SP9: -
SP10:

Relevant External Links for IARS Gene

GeneLoc Exon Structure for
IARS
ECgene alternative splicing isoforms for
IARS

Expression for IARS Gene

mRNA expression in normal human tissues for IARS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IARS Gene

This gene is overexpressed in Lymph node (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IARS Gene



SOURCE GeneReport for Unigene cluster for IARS Gene Hs.445403

genes like me logo Genes that share expression patterns with IARS: view

Protein tissue co-expression partners for IARS Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IARS Gene

Orthologs for IARS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IARS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IARS 36
  • 100 (a)
OneToOne
IARS 35
  • 99.66 (n)
  • 99.52 (a)
cow
(Bos Taurus)
Mammalia IARS 36
  • 91 (a)
OneToOne
IARS 35
  • 89.8 (n)
  • 91.13 (a)
dog
(Canis familiaris)
Mammalia IARS 35
  • 87.43 (n)
  • 90.41 (a)
IARS 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Iars 36
  • 91 (a)
OneToOne
Iars 35
  • 85.88 (n)
  • 90.72 (a)
Iars 16
oppossum
(Monodelphis domestica)
Mammalia IARS 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IARS 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Iars 35
  • 85.62 (n)
  • 90.8 (a)
chicken
(Gallus gallus)
Aves IARS 35
  • 76.26 (n)
  • 82.24 (a)
IARS 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IARS 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia iars 35
  • 71.56 (n)
  • 78.21 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6766 35
zebrafish
(Danio rerio)
Actinopterygii iars 35
  • 68.23 (n)
  • 74.76 (a)
wufi46h05 35
iars 36
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002101 35
  • 56.44 (n)
  • 60.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta Aats-ile 37
  • 59 (a)
Aats-ile 35
  • 57.03 (n)
  • 56.72 (a)
Aats-ile 36
  • 54 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea iars-1 36
  • 56 (a)
OneToOne
irs-1 37
  • 59 (a)
iars-1 35
  • 57.22 (n)
  • 57.73 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER394W 35
  • 56 (n)
  • 55.59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ILS1 35
  • 55.56 (n)
  • 54.73 (a)
ILS1 36
  • 54 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20549g 35
  • 56.37 (n)
  • 54.52 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G10320 35
  • 58.39 (n)
  • 55.99 (a)
corn
(Zea mays)
Liliopsida Zm.12745 35
rice
(Oryza sativa)
Liliopsida Os.8879 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03575 35
  • 54.86 (n)
  • 53.43 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes irs1 35
  • 56.12 (n)
  • 54.77 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
OneToOne
Species with no ortholog for IARS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IARS Gene

ENSEMBL:
Gene Tree for IARS (if available)
TreeFam:
Gene Tree for IARS (if available)

Paralogs for IARS Gene

Pseudogenes.org Pseudogenes for IARS Gene

genes like me logo Genes that share paralogs with IARS: view

No data available for Paralogs for IARS Gene

Variants for IARS Gene

Sequence variations from dbSNP and Humsavar for IARS Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_057951 -
rs556155 - 92,223,355(+) TGGCT(C/T)TGCAT nc-transcript-variant, reference, missense
rs2070053 - 92,256,766(-) GAACA(C/T)GGTTA nc-transcript-variant, reference, missense
rs140666586 - 92,274,512(+) GCCAT(A/T)CTCTT nc-transcript-variant, reference, missense
rs201071417 - 92,222,663(+) TCCCC(A/G)TTAAA nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for IARS Gene

Variant ID Type Subtype PubMed ID
nsv893573 CNV Gain 21882294
nsv6615 CNV Insertion 18451855

Variation tolerance for IARS Gene

Residual Variation Intolerance Score: 6.68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.82; 79.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IARS Gene

HapMap Linkage Disequilibrium report
IARS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IARS Gene

Disorders for IARS Gene

MalaCards: The human disease database

(1) MalaCards diseases for IARS Gene - From: GeneCards

Disorder Aliases PubMed IDs
dermatomyositis
  • amyopathic dermatomyositis
- elite association - COSMIC cancer census association via MalaCards
Search IARS in MalaCards View complete list of genes associated with diseases

Relevant External Links for IARS

Genetic Association Database (GAD)
IARS
Human Genome Epidemiology (HuGE) Navigator
IARS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IARS
genes like me logo Genes that share disorders with IARS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IARS Gene

Publications for IARS Gene

  1. Human isoleucyl-tRNA synthetase: sequence of the cDNA, alternative mRNA splicing, and the characteristics of an unusually long C-terminal extension. (PMID: 7721108) Nichols R.C. … Plotz P.H. (Gene 1995) 3 4 23 67
  2. Crystal structures of the CP1 domain from Thermus thermophilus isoleucyl-tRNA synthetase and its complex with L-valine. (PMID: 14672940) Fukunaga R. … Yokoyama S. (J. Biol. Chem. 2004) 25 26
  3. Synthesis and activity of analogues of the isoleucyl tRNA synthetase inhibitor SB-203207. (PMID: 12788342) Crasto C.F. … Easton C.J. (Bioorg. Med. Chem. 2003) 25 26
  4. Incorporation of trifluoroisoleucine into proteins in vivo. (PMID: 12783542) Wang P. … Tirrell D.A. (J. Am. Chem. Soc. 2003) 25 26
  5. Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases. (PMID: 10913161) Kang J. … Kim S. (J. Biol. Chem. 2000) 3 23

Products for IARS Gene

Sources for IARS Gene

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