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IARS Gene

protein-coding   GIFtS: 68
GCID: GC09M094972

Isoleucyl-TRNA Synthetase

  See IARS-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Isoleucyl-TRNA Synthetase1 2 3     ILRS2
IRS2 3     PRO07852
EC 6.1.1.53 8     Isoleucine TRNA Ligase 1, Cytoplasmic2
cytoplasmic1     Isoleucine--TRNA Ligase, Cytoplasmic2
Isoleucine TRNA Ligase 11     Isoleucyl-TRNA Synthetase, Cytoplasmic2
IARS12     IleRS3
ILERS2     EC 6.1.18

External Ids:    HGNC: 53301   Entrez Gene: 33762   Ensembl: ENSG000001963057   OMIM: 6007095   UniProtKB: P412523   

Export aliases for IARS gene to outside databases

Previous GC identifers: GC09M085799 GC09M086700 GC09M088271 GC09M090314 GC09M092052 GC09M094012 GC09M064650


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IARS Gene:
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their
central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are
thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the
class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune
disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. (provided by
RefSeq, Nov 2012)

GeneCards Summary for IARS Gene:
IARS (isoleucyl-tRNA synthetase) is a protein-coding gene. Diseases associated with IARS include polymyositis, and dermatomyositis. GO annotations related to this gene include aminoacyl-tRNA editing activity and isoleucine-tRNA ligase activity.

Gene Wiki entry for IARS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the IARS gene promoter:
         AREB6   GATA-3   Pbx1a   GATA-2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIARS promoter sequence
   Search Chromatin IP Primers for IARS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IARS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21   Ensembl cytogenetic band:  9q22.31   HGNC cytogenetic band: 9q21

IARS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IARS gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M094972:  view genomic region     (about GC identifiers)

Start:
94,972,489 bp from pter      End:
95,056,038 bp from pter
Size:
83,550 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SYIC_HUMAN, P41252 (See protein sequence)
Recommended Name: Isoleucine--tRNA ligase, cytoplasmic  
Size: 1262 amino acids; 144498 Da
Subunit: Part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and
Pro
Sequence caution: Sequence=BAA05835.1; Type=Erroneous initiation;
Secondary accessions: A8KAE9 Q5TCD0 Q7Z3T4 Q9H588

Explore the universe of human proteins at neXtProt for IARS: NX_P41252

Explore proteomics data for IARS at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys410, Lys450, Lys868, Lys917, Lys1051
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for IARS (P41252) (see all 23)
     YGADALR  WTTTPWT  YKAVPSW  DCWFESG 


    See IARS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002152.2  NP_038203.2  

    ENSEMBL proteins: 
     ENSP00000364794   ENSP00000364778   ENSP00000378922   ENSP00000387603   ENSP00000406448  
     ENSP00000415020   ENSP00000364780  
    Reactome Protein details: P41252

    IARS Human Recombinant Protein Products:

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    Novus Biologicals IARS Protein
    Novus Biologicals IARS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IARS

     
    Search eBioscience for Proteins for IARS 

    IARS Antibody Products:

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    LSBio Antibodies in human, mouse, rat for IARS

    IARS Assay Products:

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    Cloud-Clone Corp. ELISAs for IARS
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    Search eBioscience for ELISAs for IARS 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    aaRS1: Aminoacyl tRNA synthetases / Class I

    Selected InterPro protein domains (see all 8):
     IPR013155 V/L/I-tRNA-synth_anticodon-bd
     IPR002300 aa-tRNA-synth_Ia
     IPR001412 aa-tRNA-synth_I_CS
     IPR023586 Ile-tRNA-ligase_type2
     IPR002301 Ile-tRNA-ligase

    Graphical View of Domain Structure for InterPro Entry P41252

    ProtoNet protein and cluster: P41252

    3 Blocks protein domains:
    IPB002300 Aminoacyl-tRNA synthetase
    IPB002301 Isoleucyl-tRNA synthetase signature
    IPB013155 tRNA synthetase


    UniProtKB/Swiss-Prot: SYIC_HUMAN, P41252
    Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family


    Find genes that share domains with IARS           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYIC_HUMAN, P41252
    Catalytic activity: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)

         Genatlas biochemistry entry for IARS:
    isoleucyl-tRNA synthetase,target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis

         Enzyme Numbers (IUBMB): EC 6.1.1.51 2 EC 6.1.12

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0002161aminoacyl-tRNA editing activity IEA--
    GO:0004812aminoacyl-tRNA ligase activity ----
    GO:0004822isoleucine-tRNA ligase activity TAS--
    GO:0005515protein binding IPI10913161
         
    Find genes that share ontologies with IARS           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IARS:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IARS
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IARS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IARS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IARS

    miRNA
    Products:
        
    miRTarBase miRNAs that target IARS:
    hsa-mir-222-3p (MIRT046693), hsa-mir-196b-5p (MIRT042694), hsa-mir-652-3p (MIRT039498), hsa-mir-16-5p (MIRT032046), hsa-mir-331-3p (MIRT043474), hsa-mir-92b-3p (MIRT040670), hsa-mir-424-5p (MIRT042439), hsa-mir-100-5p (MIRT048412), hsa-mir-615-3p (MIRT039819), hsa-let-7a-5p (MIRT052634)

    Block miRNA regulation of human, mouse, rat IARS using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate IARS:
    hsa-miR-217 hsa-miR-153 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidIARS 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IARS
    Predesigned siRNA for gene silencing in human, mouse, rat IARS

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for IARS

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    OriGene ORF clones in mouse, rat for IARS
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    GenScript: all cDNA clones in your preferred vector (see all 2): IARS (NM_002161)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IARS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IARS

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IARS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYIC_HUMAN, P41252: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus4
    chloroplast2
    plasma membrane2
    cytoskeleton1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm TAS7721108
    GO:0005829cytosol TAS--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with IARS           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IARS About    
    See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    tRNA Aminoacylation0.57
    Aminoacyl-tRNA biosynthesis0.52
    Cytosolic tRNA aminoacylation0.57
    2Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with IARS           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for IARS
        Cytosolic tRNA aminoacylation


    1 Kegg Pathway  (Kegg details for IARS):
        Aminoacyl-tRNA biosynthesis

        Pathway & Disease-focused RT2 Profiler PCR Array including IARS: 
              Amino Acid Metabolism II in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IARS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IARS (P412521, 2, 3 ENSP000003647944) via UniProtKB, MINT, STRING, and/or I2D (see all 226)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB2Q006532, 3MINT-48578 MINT-48712 I2D: score=2 
    TANKQ928442, 3, ENSP000002590754MINT-48253 I2D: score=2 STRING: ENSP00000259075
    MAP3K14Q995582, 3MINT-48808 I2D: score=2 
    MAP3K3Q997592, 3MINT-48408 I2D: score=2 
    ENSG00000226589P266403, ENSP000004033594I2D: score=1 STRING: ENSP00000403359
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006428isoleucyl-tRNA aminoacylation IEA--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with IARS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IARS (SYIC)

    5 HMDB Compounds for IARS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Isoleucine(2S,3S)-2-Amino-3-methylpentanoate (see all 33)73-32-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for IARS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Isoleucine(2S,3S)-2-Amino-3-methylpentanoic acid (see all 11)73-32-5target--8146659 17139284 8129874 17016423 5111605

    6 Novoseek inferred chemical compound relationships for IARS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mupirocin 85.5 22 20176977 (2), 10821672 (2), 12652905 (2), 8540693 (1) (see all 7)
    aminoacyl-trna 82.8 2 7721108 (1)
    trna 76.4 11 14596614 (2), 10913161 (2), 8052601 (1), 9548745 (1) (see all 8)
    isoleucine 70.7 6 19557155 (2), 9548745 (1), 8692688 (1), 10066735 (1)
    valine 48.8 3 10066735 (1), 19557155 (1)
    atp 31.5 1 10821672 (1)



    Find genes that share compounds with IARS           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IARS gene (2 alternative transcripts): 
    NM_002161.5  NM_013417.3  

    Unigene Cluster for IARS:

    Isoleucyl-tRNA synthetase
    Hs.445403  [show with all ESTs]
    Unigene Representative Sequence: NM_013417
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375643(uc004art.1) ENST00000375627 ENST00000474340 ENST00000473915
    ENST00000467876 ENST00000472894 ENST00000395554 ENST00000498025 ENST00000490438
    ENST00000430417 ENST00000443024(uc004aru.3 uc010mqr.2 uc010mqt.2)
    ENST00000447699 ENST00000375629(uc004ars.1)
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate IARS:
    hsa-miR-217 hsa-miR-153 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidIARS 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IARS
    Clone
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    OriGene ORF clones in mouse, rat for IARS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): IARS (NM_002161)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IARS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IARS
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for IARS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IARS
      QuantiTect SYBR Green Assays in human, mouse, rat IARS
      QuantiFast Probe-based Assays in human, mouse, rat IARS

    Additional mRNA sequence: 

    AB209234.1 AK057920.1 AK293014.1 AK308202.1 BC008318.1 BC065552.1 BX537417.1 BX537429.1 
    BX538109.1 BX647071.1 BX647236.1 BX647430.1 BX648567.1 D28473.1 NR_073446.1 U04953.1 

    Selected DOTS entries (see all 39):

    DT.100886659  DT.91764782  DT.100011116  DT.91852124  DT.91930461  DT.455504  DT.95278997  DT.92398647 
    DT.92031077  DT.87008011  DT.101985387  DT.121158091  DT.95278994  DT.95278999  DT.100886653  DT.100886662 
    DT.304867  DT.91764781  DT.92337040  DT.100687050  DT.100886661  DT.100886664  DT.121158034  DT.91751257 

    1 AceView cDNA sequence:

    CB045335 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IARS (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
    SP1:              -                                   -                                                                                               -         
    SP2:                                                  -                                                                                               -         
    SP3:                                      -           -                                                                                               -         
    SP4:              -           -                       -                                                                                               -         
    SP5:                                                                                                                                                            

    ExUns: 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33a · 33b ^ 34 ^ 35 ^ 36a · 36b
    SP1:  -     -           -           -                                                                                         -               
    SP2:  -     -           -           -                                                                                         -               
    SP3:  -     -           -           -                                                                 -     -                 -               
    SP4:  -     -           -           -                                                                                         -               
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for IARS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    IARS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGGAGCAG
    IARS Expression
    About this image


    IARS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Kidney (Urinary System)
             Metanephros
     
     Eye (Sensory Organs)
             Lens
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Thyroid (Endocrine System)
    IARS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IARS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.445403
        Pathway & Disease-focused RT2 Profiler PCR Array including IARS: 
              Amino Acid Metabolism II in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IARS gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Iars1 , 5 isoleucine-tRNA synthetase1, 5 85.88(n)1
    90.72(a)1
      13 (25.38 cM)5
    1051481  NM_172015.31  NP_742012.21 
     496821005 
    chicken
    (Gallus gallus)
    Aves IARS1 isoleucyl-tRNA synthetase 76.26(n)
    82.24(a)
      415957  XM_414300.3  XP_414300.3 
    lizard
    (Anolis carolinensis)
    Reptilia IARS6
    isoleucyl-tRNA synthetase
    81(a)
    1 ↔ 1
    2(156384735-156498568)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia iars1 isoleucyl-tRNA synthetase 71.56(n)
    78.21(a)
      100036668  NM_001097221.1  NP_001090690.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi46h052 wufi46h05 74.41(n)   334393  BC056826.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Aats-ile1 , 3 isoleucyl-tRNA aminoacylation
    isoleucine-tRNA more3
    Isoleucyl-tRNA synthetase1
    59(a)3
    57.03(n)1
    56.72(a)1
      457851  NM_176387.21  NP_788565.11 
    worm
    (Caenorhabditis elegans)
    Secernentea irs-13
    iars-11
    isoleucyl-tRNA synthetase3
    iars-11
    59(a)3
    57.22(n)1
    57.73(a)1
      IV(10368790-10372654)3
    1779261  NM_069513.41  NP_501914.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ILS11 ILS1 55.56(n)
    54.73(a)
      852202   NP_009477.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G103201 AT4G10320 58.39(n)
    55.99(a)
      826624  NM_117100.3  NP_192770.2 
    rice
    (Oryza sativa)
    Liliopsida Os.88792 Oryza sativa (japonica cultivar-group) cDNA clone0 more 73.51(n)    AK101482.1 


    ENSEMBL Gene Tree for IARS (if available)
    TreeFam Gene Tree for IARS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IARS gene
    2 SIMAP similar genes for IARS using alignment to 10 protein entries:     SYIC_HUMAN (see all proteins):
    DKFZp686L0869    DKFZp686L17145

    Find genes that share paralogs with IARS           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for IARS
    PGOHUM00000236274 PGOHUM00000236711


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IARS (see all 1664)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1444087901,2
    --94972139(+) GGCCAC/TGCTCC 3 -- ds5001 int10--------
    rs109922721,2
    C,H--94972280(+) tcttaG/Tagttg 3 -- ds5001 int14Minor allele frequency- T:0.00NS EA 420
    rs795905811,2
    C,F--94972350(+) CCACAC/ATGCAG 3 -- ds5001 int11Minor allele frequency- A:0.06WA 118
    rs64794121,2
    C,F,A--94972397(+) ccgttT/Catcct 3 -- ds5001 int18Minor allele frequency- C:0.38NA WA CSA 250
    rs1817052611,2
    --94972456(+) TCATCG/TGCTTC 3 -- ds5001 int10--------
    rs66515321,2
    C,F,A,H--94972484(+) TCACCC/TGGGAT 3 -- ds5001 int128Minor allele frequency- T:0.41NS EA NA WA CSA 2498
    rs1871239381,2
    --94972604(+) GAGAAC/TGAATT 3 -- ut31 nc-transcript-variant0--------
    rs1483807071,2
    C--94972682(+) AAATTA/GTCCAG 3 -- ut31 nc-transcript-variant0--------
    rs1905304831,2
    --94972891(+) CTAAGA/GTTAAG 3 -- ut31 nc-transcript-variant0--------
    rs10587511,2
    C,F,O,A,H--94972916(-) TTGAGA/TCCTCA 3 -- ut31 nc-transcript-variant15Minor allele frequency- T:0.09MN NA NS EA CSA WA 993

    HapMap Linkage Disequilibrium report for IARS (94972489 - 95056038 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IARS:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6615CNV Insertion18451855
    nsv893573CNV Gain21882294

    Human Gene Mutation Database (HGMD): IARS
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IARS
    DNA2.0 Custom Variant and Variant Library Synthesis for IARS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600709    OMIM disorders: --

    3 diseases for IARS:    
    About MalaCards
    polymyositis    dermatomyositis    turcot syndrome


    Find genes that share disorders with IARS           About GenesLikeMe

    Genetic Association Database (GAD): IARS
    Human Genome Epidemiology (HuGE) Navigator: IARS (2 documents)

    Export disorders for IARS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IARS gene, integrated from 10 sources (see all 77):
    (articles sorted by number of sources associating them with IARS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human isoleucyl-tRNA synthetase: sequence of the cDNA, alternative mRNA splicing, and the characteristics of an unusually long C-terminal extension. (PubMed id 7721108)1, 2, 9 Nichols R.C.... Plotz P.H. (Gene 1995)
    2. Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence of the anticodon-binding domain and acquisition of a new structural unit. (PubMed id 8052601)1, 2, 9 Shiba K.... Noda T. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    6. Assignment of two human autoantigen genes-isoleucyl-tRNA synthetase locates to 9q21 and lysyl-tRNA synthetase locates to 16q23-q24. (PubMed id 8812440)1, 3 Nichols R.C....Liu P. (Genomics 1996)
    7. Heat shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases. (PubMed id 10913161)1, 9 Kang J....Kim S. (J. Biol. Chem. 2000)
    8. Evidence for distinct locations for metal binding sites in two closely related class I tRNA synthetases. (PubMed id 8129874)7, 9 Schimmel P....Schmidt E. (amp 1993)
    9. Interaction between human tRNA synthetases involves repeated sequence elements. (PubMed id 8816763)1, 9 Rho S.B....Kim S. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    10. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3376 HGNC: 5330 AceView: IARS.2 Ensembl:ENSG00000196305 euGenes: HUgn3376
    ECgene: IARS Kegg: 3376 H-InvDB: IARS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IARS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IARS gene:
    Search GeneIP for patents involving IARS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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