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IAPP Gene

protein-coding   GIFtS: 62
GCID: GC12P021507

Islet Amyloid Polypeptide

  See IAPP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Islet Amyloid Polypeptide1 2     DAP2 3
amylin1 2     IAP2
Diabetes-Associated Peptide2 3     Islet Amyloid Polypeptide (Diabetes-Associated Peptide; Amylin)2
Insulinoma Amyloid Peptide2 3     Amylin3

External Ids:    HGNC: 53291   Entrez Gene: 33752   Ensembl: ENSG000001213517   OMIM: 1479405   UniProtKB: P109973   

Export aliases for IAPP gene to outside databases

Previous GC identifers: GC12P021811 GC12P021527 GC12P021426 GC12P021417 GC12P021299


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IAPP Gene:
Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes
mellitus type II, or harboring an insulinoma. While the association of amylin with the development of type II
diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies
suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce
apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II
diabetes. (provided by RefSeq, Apr 2011)

GeneCards Summary for IAPP Gene:
IAPP (islet amyloid polypeptide) is a protein-coding gene. Diseases associated with IAPP include islet cell tumor, and insulinoma. GO annotations related to this gene include hormone activity and identical protein binding.

UniProtKB/Swiss-Prot: IAPP_HUMAN, P10997
Function: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not
affecting adipocyte glucose metabolism

Gene Wiki entry for IAPP (Amylin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the IAPP gene promoter:
         TBP   GR   Pbx1a   AP-1   GR-beta   ATF-2   Cdc5   c-Jun   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIAPP promoter sequence
   Search Chromatin IP Primers for IAPP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IAPP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.1   Ensembl cytogenetic band:  12p12.1   HGNC cytogenetic band: 12p12.1

IAPP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IAPP gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P021507:  view genomic region     (about GC identifiers)

Start:
21,507,893 bp from pter      End:
21,532,914 bp from pter
Size:
25,022 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IAPP_HUMAN, P10997 (See protein sequence)
Recommended Name: Islet amyloid polypeptide precursor  
Size: 89 amino acids; 9806 Da
Subunit: Interacts with IDE and INS. Can form homodimers. Interaction with INS inhibits homodimerization and
fibril formation
Mass spectrometry: Mass=3936; Method=MALDI; Range=34-70; Source=PubMed:17374526;
Miscellaneous: IAPP is the peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and
in insulinomas
Selected PDB 3D structures from and Proteopedia for IAPP (see all 13):
1KUW (3D)        2G48 (3D)        2KB8 (3D)        2L86 (3D)        3FPO (3D)        3FR1 (3D)    
Secondary accessions: Q0ZD87 Q14598

Explore the universe of human proteins at neXtProt for IAPP: NX_P10997

Explore proteomics data for IAPP at MOPED

Post-translational modifications: 

  • Amyloid fibrils are degraded by IDE1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IAPP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000406.1  
    ENSEMBL proteins: 
     ENSP00000437357   ENSP00000240652   ENSP00000445711   ENSP00000445980   ENSP00000437559  
    Reactome Protein details: P10997

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    Cloud-Clone Corp. Proteins for IAPP

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    5 InterPro protein domains:
     IPR018360 Calcitonin_CS
     IPR001693 Calcitonin_peptide-like
     IPR000443 Pro-islet_amyloid_polypep
     IPR021116 Procalcitonin/adrenomedullin
     IPR021117 Procalcitonin-like

    Graphical View of Domain Structure for InterPro Entry P10997

    ProtoNet protein and cluster: P10997

    1 Blocks protein domain: IPB000443 Islet amyloid protein (amylin) signature

    UniProtKB/Swiss-Prot: IAPP_HUMAN, P10997
    Domain: The mature protein is largely unstructured in the absence of a cognate ligand, and has a strong tendency
    to form fibrillar aggregates. Homodimerization may be the first step of amyloid formation
    Similarity: Belongs to the calcitonin family


    Find genes that share domains with IAPP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IAPP_HUMAN, P10997
    Function: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not
    affecting adipocyte glucose metabolism

         Genatlas biochemistry entry for IAPP:
    islet amyloid polypeptide

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS10342886
    GO:0005179hormone activity IEA--
    GO:0042802identical protein binding IPI--
         
    Find genes that share ontologies with IAPP           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Iapp):
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  skeleton 

    Find genes that share phenotypes with IAPP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Iapptm1Sgm for IAPP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IAPP
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IAPP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IAPP

    miRNA
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    miRTarBase miRNAs that target IAPP:
    hsa-mir-26b-5p (MIRT030101), hsa-mir-335-5p (MIRT018914)

    Block miRNA regulation of human, mouse, rat IAPP using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate IAPP:
    hsa-miR-634 hsa-miR-155 hsa-miR-205* hsa-miR-1284
    SwitchGear 3'UTR luciferase reporter plasmidIAPP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IAPP
    Predesigned siRNA for gene silencing in human, mouse, rat IAPP

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: IAPP (NM_000415)
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    In Situ Assay
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IAPP_HUMAN, P10997: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    plasma membrane2
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0043025neuronal cell body IEA--

    Find genes that share ontologies with IAPP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IAPP About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of beta-cell development
    Regulation of beta-cell development0.64
    Maturity onset diabetes of the young0.61
    Regulation of gene expression in beta cells0.64
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3ADP signalling through P2Y purinoceptor 12
    Class B/2 (Secretin family receptors)0.36
    Calcitonin-like ligand receptors0.00
    4Peptide ligand-binding receptors
    GPCR ligand binding0.71
    5RNA Polymerase I Promoter Opening
    Amyloids0.68


    Find genes that share SuperPaths with IAPP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IAPP (see all 15)
        MIF Regulation of Innate Immune Cells
    STAT3 Pathway
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C

    1 BioSystems Pathway for IAPP
        Integrated Pancreatic Cancer Pathway


    4 Reactome Pathways for IAPP
        Amyloids
    Regulation of gene expression in beta cells
    Calcitonin-like ligand receptors
    G alpha (s) signalling events


    1 Kegg Pathway  (Kegg details for IAPP):
        Maturity onset diabetes of the young

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IAPP: 
              Terminal Differentiation Markers in human mouse rat
              Obesity in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IAPP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IAPP (P109971, 3 ENSP000002406524) via UniProtKB, MINT, STRING, and/or I2D (see all 94)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAMP2O608953, ENSP000002537964I2D: score=2 STRING: ENSP00000253796
    PCSK1P291203, ENSP000003080244I2D: score=1 STRING: ENSP00000308024
    PDX1P529453, ENSP000003704214I2D: score=1 STRING: ENSP00000370421
    PCSK2P165193, ENSP000002625454I2D: score=1 STRING: ENSP00000262545
    RAMP1O608943, ENSP000002546614I2D: score=1 STRING: ENSP00000254661
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS8152488
    GO:0007165signal transduction TAS10342886
    GO:0007267cell-cell signaling TAS2608057
    GO:0019233sensory perception of pain IEA--
    GO:0031018endocrine pancreas development TAS--

    Find genes that share ontologies with IAPP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IAPP

    Selected Novoseek inferred chemical compound relationships for IAPP gene (see all 73)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pramlintide 97.4 150 12534323 (13), 11763160 (4), 11979398 (3), 11472273 (3) (see all 81)
    i-app 95.7 354 10907112 (10), 19475663 (7), 7935487 (7), 1541234 (6) (see all 99)
    ac 187 87.1 7 8882637 (2), 10433998 (1), 12611974 (1), 16492540 (1)
    exenatide 83.8 23 14725490 (4), 14992323 (1), 16625817 (1), 17272793 (1) (see all 14)
    amylinamide 74.7 3 1646609 (3)
    liraglutide 70.9 4 16625817 (1), 18794593 (1), 20234354 (1), 15340100 (1)
    thioflavin t 69.9 5 9568695 (1), 16884500 (1), 11374584 (1), 19100955 (1)
    glucose 69.2 294 10946889 (8), 1860552 (7), 8163050 (6), 1541239 (6) (see all 99)
    incretin 66.5 13 17367252 (2), 7692203 (2), 16751350 (1), 17272793 (1) (see all 11)
    c-peptide 65.9 41 9212327 (4), 20005261 (4), 15057546 (2), 18624122 (2) (see all 22)



    Find genes that share compounds with IAPP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IAPP gene: 
    NM_000415.2  

    Unigene Cluster for IAPP:

    Islet amyloid polypeptide
    Hs.46835  [show with all ESTs]
    Unigene Representative Sequence: NM_000415
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000539393 ENST00000240652(uc001rev.3) ENST00000542023 ENST00000537593
    ENST00000535428
    miRNA
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    hsa-miR-634 hsa-miR-155 hsa-miR-205* hsa-miR-1284
    SwitchGear 3'UTR luciferase reporter plasmidIAPP 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    DQ516082.1 J04422.1 X14904.1 X14905.1 

    6 DOTS entries:

    DT.95293617  DT.121183677  DT.100779782  DT.100779779  DT.99931396  DT.92435879 

    Selected AceView cDNA sequences (see all 300):

    BM505548 BQ478162 BQ581762 BM313621 CA943747 BQ417003 CA943882 BG654456 
    BU952566 BI324887 BQ613782 CB068471 BM512290 BU074561 BM314275 CA776720 
    BI712471 BU071178 BU949545 CA774826 BI712710 BU076053 BM509215 BM857649 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for IAPP    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b
    SP1:              -           -               
    SP2:              -                           
    SP3:                          -               


    ECgene alternative splicing isoforms for IAPP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IAPP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    IAPP Expression
    About this image


    IAPP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 4 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
             Islets of Langerhans
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
     
     Neural Tube (Nervous System)
             Floor plate-like cells
    IAPP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IAPP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.46835
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IAPP: 
              Terminal Differentiation Markers in human mouse rat
              Obesity in human mouse rat
              Embryonic Stem Cells in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IAPP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IAPP gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Iapp1 , 5 islet amyloid polypeptide1, 5 76.63(n)1
    68.97(a)1
      6 (73.81 cM)5
    158741  NM_010491.21  NP_034621.11 
     1422984235 
    chicken
    (Gallus gallus)
    Aves IAPP6
    Gallus gallus islet amyloid polypeptide (IAPP), mR...
    43(a)
    1 ↔ 1
    1(65417044-65421190)
    lizard
    (Anolis carolinensis)
    Reptilia IAPP6
    islet amyloid polypeptide
    42(a)
    1 ↔ 1
    5(8298582-8305508)
    zebrafish
    (Danio rerio)
    Actinopterygii IAPP6
    islet amyloid polypeptide
    34(a)
    1 ↔ 1
    5(62661681-62676468) ENSDARG00000074122


    ENSEMBL Gene Tree for IAPP (if available)
    TreeFam Gene Tree for IAPP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IAPP gene
    2 SIMAP similar genes for IAPP using alignment to 4 protein entries:     IAPP_HUMAN (see all proteins):
    CALCB    CALCA

    Find genes that share paralogs with IAPP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for IAPP    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18002031,2,4
    ----see VAR_0120802 mis40--------

    HapMap Linkage Disequilibrium report for IAPP (21507893 - 21532914 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for IAPP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv470274CNV Loss18288195
    nsv469161CNV Loss19166990
    nsv469162CNV Loss19166990
    nsv519603CNV Gain+Loss19592680

    Human Gene Mutation Database (HGMD): IAPP
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 147940    OMIM disorders: --

    15 diseases for IAPP:    
    About MalaCards
    islet cell tumor    insulinoma    pancreatic islet cell tumors    monogenic diabetes
    hyperglycemia    alcoholic pancreatitis    gastrinoma    glucose intolerance
    type 1 diabetes mellitus    diabetes mellitus    type 2 diabetes mellitus    insulin resistance
    essential hypertension    pancreatic cancer    obesity

    6 diseases from the University of Copenhagen DISEASES database for IAPP:
    Diabetes mellitus     Hyperglycemia     Amyloidosis     Alzheimer's disease
    Pancreatic cancer     Hypoglycemia

    Find genes that share disorders with IAPP           About GenesLikeMe

    Selected Novoseek inferred disease relationships for IAPP gene (see all 61)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    niddm 77.2 113 9589246 (4), 12534323 (4), 7705017 (3), 1950379 (3) (see all 63)
    hyperglycemia 68.6 31 8842609 (2), 1534057 (1), 16492545 (1), 17617279 (1) (see all 24)
    amyloid deposition 66.8 14 1541234 (2), 8111613 (1), 12941771 (1), 12706321 (1) (see all 11)
    hyperglucagonemia 63.6 5 12384827 (2), 8842609 (2), 11979398 (1)
    insulinoma 62.7 28 8317551 (3), 14507315 (3), 12941771 (2), 9166666 (1) (see all 19)
    insulin resistance 61.1 52 8967027 (3), 8877314 (2), 2204154 (2), 9814997 (2) (see all 39)
    hypoglycemia 60.6 12 16492545 (2), 1787825 (2), 16492543 (2), 8772580 (1) (see all 8)
    diabetes mellitus 57 36 8152488 (2), 11772274 (2), 1737562 (1), 7594773 (1) (see all 31)
    amyloidosis 56.3 13 9568695 (2), 19266159 (1), 15878744 (1), 8296225 (1) (see all 12)
    impaired glucose tolerance 52.8 14 10946889 (4), 9568698 (2), 1756902 (1), 8877314 (1) (see all 8)

    Genetic Association Database (GAD): IAPP
    Human Genome Epidemiology (HuGE) Navigator: IAPP (13 documents)

    Export disorders for IAPP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IAPP gene, integrated from 10 sources (see all 776):
    (articles sorted by number of sources associating them with IAPP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Missense mutation of amylin gene (S20G) in Japanese NIDDM patients. (PubMed id 8772735)1, 2, 4, 9 Sakagashira S.... Nanjo K. (Diabetes 1996)
    2. Characterization of the human islet amyloid polypeptide/amylin gene transcripts: identification of a new polyadenylation site. (PubMed id 1282806)1, 2, 9 Hoeppener J.W.M....Jansz H.S. (Biochem. Biophys. Res. Commun. 1992)
    3. Islet amyloid polypeptide: structure and upstream sequences of the IAPP gene in rat and man. (PubMed id 2223885)1, 2, 9 van Mansfeld A.D.M.... Jansz H.S. (Biochim. Biophys. Acta 1990)
    4. Islet amyloid polypeptide gene promoter polymorphisms are not associated with Type 2 diabetes or with the severity of islet amyloidosis. (PubMed id 15878744)1, 4, 9 Esapa C....Clark A. (Biochim. Biophys. Acta 2005)
    5. Cloning and expression of human islet amyloid polypeptide in cultured cells. (PubMed id 17374526)1, 2, 9 Bhattacharya S.... Singh S. (Biochem. Biophys. Res. Commun. 2007)
    6. S20G mutation of the amylin gene is associated with a lower body mass index in Korean type 2 diabetic patients. (PubMed id 12706321)1, 4, 9 Cho Y.M....Lee H.K. (Diabetes Res. Clin. Pract. 2003)
    7. Polymorphism in intron 2 of islet amyloid polypeptide gene is associated with lower low-density lipoprotein cholesterol in nondiabetic subjects and in type 2 diabetic patients. (PubMed id 12588049)1, 4, 9 Rojas I....Novials A. (Endocrine 2002)
    8. Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin. (PubMed id 2039456)1, 2, 9 Hubbard J.A.M....Price N.C. (Biochem. J. 1991)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PubMed id 20416077)1, 4 Ban H.J....Park K.J. (BMC Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3375 HGNC: 5329 AceView: IAPP Ensembl:ENSG00000121351 euGenes: HUgn3375
    ECgene: IAPP Kegg: 3375 H-InvDB: IAPP

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IAPP Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Amylin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for IAPP gene:
    Search GeneIP for patents involving IAPP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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