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Aliases for IAPP Gene

Aliases for IAPP Gene

  • Islet Amyloid Polypeptide 2 3 5
  • Amylin 2 3 4
  • Diabetes-Associated Peptide 3 4
  • Insulinoma Amyloid Peptide 3 4
  • DAP 3 4
  • Islet Amyloid Polypeptide (Diabetes-Associated Peptide; Amylin) 3
  • IAP 3

External Ids for IAPP Gene

Previous GeneCards Identifiers for IAPP Gene

  • GC12P021811
  • GC12P021527
  • GC12P021426
  • GC12P021417
  • GC12P021299
  • GC12P021507

Summaries for IAPP Gene

Entrez Gene Summary for IAPP Gene

  • The protein encoded by this gene is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. Studies suggest that this protein, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. This protein also exhibits an bactericidal, antimicrobial activity. [provided by RefSeq, Sep 2014]

GeneCards Summary for IAPP Gene

IAPP (Islet Amyloid Polypeptide) is a Protein Coding gene. Diseases associated with IAPP include Insulinoma and Islet Cell Tumor. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Integrated Pancreatic Cancer Pathway. GO annotations related to this gene include identical protein binding and hormone activity.

UniProtKB/Swiss-Prot for IAPP Gene

  • Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

Gene Wiki entry for IAPP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IAPP Gene

Genomics for IAPP Gene

Regulatory Elements for IAPP Gene

Enhancers for IAPP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IAPP on UCSC Golden Path with GeneCards custom track

Genomic Location for IAPP Gene

Chromosome:
12
Start:
21,354,959 bp from pter
End:
21,379,980 bp from pter
Size:
25,022 bases
Orientation:
Plus strand

Genomic View for IAPP Gene

Genes around IAPP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IAPP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IAPP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IAPP Gene

Proteins for IAPP Gene

  • Protein details for IAPP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10997-IAPP_HUMAN
    Recommended name:
    Islet amyloid polypeptide
    Protein Accession:
    P10997
    Secondary Accessions:
    • Q0ZD87
    • Q14598

    Protein attributes for IAPP Gene

    Size:
    89 amino acids
    Molecular mass:
    9806 Da
    Quaternary structure:
    • Interacts with IDE and INS. Can form homodimers. Interaction with INS inhibits homodimerization and fibril formation.
    Miscellaneous:
    • IAPP is the peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas.

    Three dimensional structures from OCA and Proteopedia for IAPP Gene

neXtProt entry for IAPP Gene

Proteomics data for IAPP Gene at MOPED

Post-translational modifications for IAPP Gene

Other Protein References for IAPP Gene

No data available for DME Specific Peptides for IAPP Gene

Domains & Families for IAPP Gene

Gene Families for IAPP Gene

Suggested Antigen Peptide Sequences for IAPP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10997

UniProtKB/Swiss-Prot:

IAPP_HUMAN :
  • The mature protein is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates. Homodimerization may be the first step of amyloid formation.
  • Belongs to the calcitonin family.
Domain:
  • The mature protein is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates. Homodimerization may be the first step of amyloid formation.
Family:
  • Belongs to the calcitonin family.
genes like me logo Genes that share domains with IAPP: view

Function for IAPP Gene

Molecular function for IAPP Gene

GENATLAS Biochemistry:
islet amyloid polypeptide
UniProtKB/Swiss-Prot Function:
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

Gene Ontology (GO) - Molecular Function for IAPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with IAPP: view
genes like me logo Genes that share phenotypes with IAPP: view

Animal Models for IAPP Gene

MGI Knock Outs for IAPP:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IAPP Gene

Localization for IAPP Gene

Subcellular locations from UniProtKB/Swiss-Prot for IAPP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IAPP Gene COMPARTMENTS Subcellular localization image for IAPP gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for IAPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
genes like me logo Genes that share ontologies with IAPP: view

Pathways & Interactions for IAPP Gene

genes like me logo Genes that share pathways with IAPP: view

Gene Ontology (GO) - Biological Process for IAPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 8152488
GO:0007165 signal transduction TAS 10342886
GO:0019233 sensory perception of pain IEA --
GO:0031018 endocrine pancreas development TAS --
GO:0045779 negative regulation of bone resorption IEA --
genes like me logo Genes that share ontologies with IAPP: view

No data available for SIGNOR curated interactions for IAPP Gene

Drugs & Compounds for IAPP Gene

(42) Drugs for IAPP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(31) Additional Compounds for IAPP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IAPP: view

Transcripts for IAPP Gene

Unigene Clusters for IAPP Gene

Islet amyloid polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IAPP Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1: - -
SP2: -
SP3: -

Relevant External Links for IAPP Gene

GeneLoc Exon Structure for
IAPP
ECgene alternative splicing isoforms for
IAPP

Expression for IAPP Gene

mRNA expression in normal human tissues for IAPP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IAPP Gene

This gene is overexpressed in Pancreas (x51.2).

Protein differential expression in normal tissues from HIPED for IAPP Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IAPP Gene



SOURCE GeneReport for Unigene cluster for IAPP Gene Hs.46835

genes like me logo Genes that share expression patterns with IAPP: view

Protein tissue co-expression partners for IAPP Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for IAPP Gene

Orthologs for IAPP Gene

This gene was present in the common ancestor of chordates.

Orthologs for IAPP Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia IAPP 35
  • 83.9 (n)
  • 82.02 (a)
IAPP 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Iapp 35
  • 76.63 (n)
  • 68.97 (a)
Iapp 16
Iapp 36
  • 63 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IAPP 35
  • 99.25 (n)
  • 97.75 (a)
IAPP 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Iapp 35
  • 75.29 (n)
  • 68.24 (a)
cow
(Bos Taurus)
Mammalia IAPP 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IAPP 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves IAPP 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IAPP 36
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii IAPP 36
  • 34 (a)
OneToOne
Species with no ortholog for IAPP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IAPP Gene

ENSEMBL:
Gene Tree for IAPP (if available)
TreeFam:
Gene Tree for IAPP (if available)

Paralogs for IAPP Gene

(2) SIMAP similar genes for IAPP Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with IAPP: view

No data available for Paralogs for IAPP Gene

Variants for IAPP Gene

Sequence variations from dbSNP and Humsavar for IAPP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_012080 -

Structural Variations from Database of Genomic Variants (DGV) for IAPP Gene

Variant ID Type Subtype PubMed ID
nsv469161 CNV Loss 19166990
nsv519603 CNV Gain+Loss 19592680
nsv470274 CNV Loss 18288195
nsv469162 CNV Loss 19166990

Variation tolerance for IAPP Gene

Residual Variation Intolerance Score: 72.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IAPP Gene

Human Gene Mutation Database (HGMD)
IAPP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IAPP Gene

Disorders for IAPP Gene

MalaCards: The human disease database

(18) MalaCards diseases for IAPP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
insulinoma
  • islet cell tumor
islet cell tumor
  • pancreatic endocrine carcinoma
diabetes mellitus, insulin-dependent
  • diabetes, type 1
nasu-hakola disease
  • polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy
hyperglycemia
- elite association - COSMIC cancer census association via MalaCards
Search IAPP in MalaCards View complete list of genes associated with diseases

Relevant External Links for IAPP

Genetic Association Database (GAD)
IAPP
Human Genome Epidemiology (HuGE) Navigator
IAPP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IAPP
genes like me logo Genes that share disorders with IAPP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IAPP Gene

Publications for IAPP Gene

  1. Missense mutation of amylin gene (S20G) in Japanese NIDDM patients. (PMID: 8772735) Sakagashira S. … Nanjo K. (Diabetes 1996) 3 4 23 48 67
  2. Increased secretion of amylin in women with polycystic ovary syndrome. (PMID: 19338997) James S. … Nagamani M. (Fertil. Steril. 2010) 3 23
  3. Reduced amylin levels are associated with low bone mineral density in women with anorexia nervosa. (PMID: 19931436) Wojcik M.H. … Miller K.K. (Bone 2010) 3 23
  4. Cholesterol regulates assembly of human islet amyloid polypeptide on model membranes. (PMID: 19720065) Cho W.J. … Jeremic A.M. (J. Mol. Biol. 2009) 3 23
  5. Atomic structure of the cross-beta spine of islet amyloid polypeptide (amylin). (PMID: 18556473) Wiltzius J.J. … Eisenberg D. (Protein Sci. 2008) 3 23

Products for IAPP Gene

Sources for IAPP Gene

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