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Aliases for IAPP Gene

Aliases for IAPP Gene

  • Islet Amyloid Polypeptide 2 3
  • Amylin 2 3 4
  • Diabetes-Associated Peptide 3 4
  • Insulinoma Amyloid Peptide 3 4
  • DAP 3 4
  • Islet Amyloid Polypeptide (Diabetes-Associated Peptide; Amylin) 3
  • Amylin) 6
  • IAP 3

External Ids for IAPP Gene

Previous GeneCards Identifiers for IAPP Gene

  • GC12P021811
  • GC12P021527
  • GC12P021426
  • GC12P021417
  • GC12P021299
  • GC12P021507

Summaries for IAPP Gene

Entrez Gene Summary for IAPP Gene

  • The protein encoded by this gene is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. Studies suggest that this protein, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. This protein also exhibits an bactericidal, antimicrobial activity. [provided by RefSeq, Sep 2014]

GeneCards Summary for IAPP Gene

IAPP (Islet Amyloid Polypeptide) is a Protein Coding gene. Diseases associated with IAPP include insulinoma and islet cell tumor. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include identical protein binding and hormone activity.

UniProtKB/Swiss-Prot for IAPP Gene

  • Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism

Gene Wiki entry for IAPP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IAPP Gene

Genomics for IAPP Gene

Regulatory Elements for IAPP Gene

Genomic Location for IAPP Gene

Start:
21,354,959 bp from pter
End:
21,379,980 bp from pter
Size:
25,022 bases
Orientation:
Plus strand

Genomic View for IAPP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IAPP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IAPP Gene

Proteins for IAPP Gene

  • Protein details for IAPP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10997-IAPP_HUMAN
    Recommended name:
    Islet amyloid polypeptide
    Protein Accession:
    P10997
    Secondary Accessions:
    • Q0ZD87
    • Q14598

    Protein attributes for IAPP Gene

    Size:
    89 amino acids
    Molecular mass:
    9806 Da
    Quaternary structure:
    • Interacts with IDE and INS. Can form homodimers. Interaction with INS inhibits homodimerization and fibril formation.
    Miscellaneous:
    • IAPP is the peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas

    Three dimensional structures from OCA and Proteopedia for IAPP Gene

neXtProt entry for IAPP Gene

Proteomics data for IAPP Gene at MOPED

Post-translational modifications for IAPP Gene

Other Protein References for IAPP Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IAPP Gene

Domains for IAPP Gene

Gene Families for IAPP Gene

HGNC:

Suggested Antigen Peptide Sequences for IAPP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10997

UniProtKB/Swiss-Prot:

IAPP_HUMAN :
  • P10997
Domain:
  • The mature protein is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates. Homodimerization may be the first step of amyloid formation.
Family:
  • Belongs to the calcitonin family.
genes like me logo Genes that share domains with IAPP: view

Function for IAPP Gene

Molecular function for IAPP Gene

GENATLAS Biochemistry: islet amyloid polypeptide
UniProtKB/Swiss-Prot Function: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism

Gene Ontology (GO) - Molecular Function for IAPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 10342886
GO:0005179 hormone activity IEA --
GO:0042802 identical protein binding IPI 21130765
genes like me logo Genes that share ontologies with IAPP: view
genes like me logo Genes that share phenotypes with IAPP: view

Animal Models for IAPP Gene

MGI Knock Outs for IAPP:

Animal Model Products

CRISPR Products

miRNA for IAPP Gene

miRTarBase miRNAs that target IAPP

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IAPP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IAPP Gene

Localization for IAPP Gene

Subcellular locations from UniProtKB/Swiss-Prot for IAPP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IAPP Gene COMPARTMENTS Subcellular localization image for IAPP gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for IAPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with IAPP: view

Pathways for IAPP Gene

genes like me logo Genes that share pathways with IAPP: view

Pathways by source for IAPP Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for IAPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 8152488
GO:0007165 signal transduction TAS 10342886
GO:0007267 cell-cell signaling TAS 2608057
GO:0019233 sensory perception of pain IEA --
GO:0031018 endocrine pancreas development TAS --
genes like me logo Genes that share ontologies with IAPP: view

Compounds for IAPP Gene

(73) Novoseek inferred chemical compound relationships for IAPP Gene

Compound -log(P) Hits PubMed IDs
pramlintide 97.4 127
i-app 95.7 217
ac 187 87.1 5
exenatide 83.8 17
amylinamide 74.7 3
genes like me logo Genes that share compounds with IAPP: view

Transcripts for IAPP Gene

mRNA/cDNA for IAPP Gene

Unigene Clusters for IAPP Gene

Islet amyloid polypeptide:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IAPP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IAPP Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1: - -
SP2: -
SP3: -

Relevant External Links for IAPP Gene

GeneLoc Exon Structure for
IAPP
ECgene alternative splicing isoforms for
IAPP

Expression for IAPP Gene

mRNA expression in normal human tissues for IAPP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IAPP Gene

This gene is overexpressed in Pancreas (51.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IAPP Gene

SOURCE GeneReport for Unigene cluster for IAPP Gene Hs.46835

genes like me logo Genes that share expressions with IAPP: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for IAPP Gene

Orthologs for IAPP Gene

This gene was present in the common ancestor of chordates.

Orthologs for IAPP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IAPP 35
  • 99.25 (n)
  • 97.75 (a)
IAPP 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IAPP 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IAPP 35
  • 83.9 (n)
  • 82.02 (a)
IAPP 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Iapp 35
  • 76.63 (n)
  • 68.97 (a)
Iapp 16
Iapp 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IAPP 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Iapp 35
  • 75.29 (n)
  • 68.24 (a)
chicken
(Gallus gallus)
Aves IAPP 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IAPP 36
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii IAPP 36
  • 34 (a)
OneToOne
Species with no ortholog for IAPP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IAPP Gene

ENSEMBL:
Gene Tree for IAPP (if available)
TreeFam:
Gene Tree for IAPP (if available)

Paralogs for IAPP Gene

Selected SIMAP similar genes for IAPP Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with IAPP: view

No data available for Paralogs for IAPP Gene

Variants for IAPP Gene

Sequence variations from dbSNP and Humsavar for IAPP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
VAR_012080 -

Structural Variations from Database of Genomic Variants (DGV) for IAPP Gene

Variant ID Type Subtype PubMed ID
nsv469161 CNV Loss 19166990
nsv519603 CNV Gain+Loss 19592680
nsv470274 CNV Loss 18288195
nsv469162 CNV Loss 19166990

Relevant External Links for IAPP Gene

HapMap Linkage Disequilibrium report
IAPP
Human Gene Mutation Database (HGMD)
IAPP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IAPP Gene

Disorders for IAPP Gene

(61) Novoseek inferred disease relationships for IAPP Gene

Disease -log(P) Hits PubMed IDs
niddm 77.2 88
hyperglycemia 68.6 25
amyloid deposition 66.8 12
hyperglucagonemia 63.6 5
insulinoma 62.7 24

Relevant External Links for IAPP

Genetic Association Database (GAD)
IAPP
Human Genome Epidemiology (HuGE) Navigator
IAPP
genes like me logo Genes that share disorders with IAPP: view

No data available for UniProtKB/Swiss-Prot for IAPP Gene

Publications for IAPP Gene

  1. Missense mutation of amylin gene (S20G) in Japanese NIDDM patients. (PMID: 8772735) Sakagashira S. … Nanjo K. (Diabetes 1996) 3 4 23 48
  2. Characterization of the human islet amyloid polypeptide/amylin gene transcripts: identification of a new polyadenylation site. (PMID: 1282806) Hoeppener J.W.M. … Jansz H.S. (Biochem. Biophys. Res. Commun. 1992) 3 4 23
  3. Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin. (PMID: 2039456) Hubbard J.A.M. … Price N.C. (Biochem. J. 1991) 3 4 23
  4. Polymorphism in intron 2 of islet amyloid polypeptide gene is associated with lower low-density lipoprotein cholesterol in nondiabetic subjects and in type 2 diabetic patients. (PMID: 12588049) Rojas I. … Novials A. (Endocrine 2002) 3 23 48
  5. S20G mutation of the amylin gene is associated with a lower body mass index in Korean type 2 diabetic patients. (PMID: 12706321) Cho Y.M. … Lee H.K. (Diabetes Res. Clin. Pract. 2003) 3 23 48

Products for IAPP Gene

Sources for IAPP Gene

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