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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

IAPP Gene

protein-coding GIFtS: 63
GCID: GC12P021507

islet amyloid polypeptide

Explore 59 diseases affiliated with
IAPP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Islet Amyloid Polypeptide¹ ²		AMYLIN¹
DAP¹ ² ³		Amylin³
IAP¹ ²		Islet Amyloid Polypeptide (Diabetes-Associated Peptide; Amylin)²
Diabetes-Associated Peptide² ³		Amylin³
Insulinoma Amyloid Peptide² ³

External Ids:	HGNC: 5329¹	Entrez Gene: 3375²	Ensembl: ENSG00000121351⁷	OMIM: 147940⁵	UniProtKB: P10997³

Export aliases for IAPP gene to outside databases

Previous GC identifers: GC12P021811 GC12P021527 GC12P021426 GC12P021417 GC12P021299

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IAPP:

Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes

mellitus type II, or harboring an insulinoma. While the association of amylin with the development of type II diabetes

has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that

amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in

particular cultured cells, an effect that may be relevant to the development of type II diabetes. (provided by RefSeq,

Apr 2011)

UniProtKB/Swiss-Prot: IAPP_HUMAN, P10997

Function: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not

affecting adipocyte glucose metabolism

Gene Wiki entry for IAPP (Amylin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the IAPP gene promoter:
TBP GR Pbx1a AP-1 GR-beta ATF-2 Cdc5 c-Jun GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IAPP promoter sequence

Search SABiosciences Chromatin IP Primers for IAPP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IAPP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.1 Ensembl cytogenetic band: 12p12.1 HGNC cytogenetic band: 12p12.1

IAPP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IAPP gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P021507: view genomic region (about GC identifiers)

Start:	21,507,893 bp from pter	End:	21,532,914 bp from pter
Size:	25,022 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: IAPP_HUMAN, P10997 (See protein sequence)

Recommended Name: Islet amyloid polypeptide precursor

Size: 89 amino acids; 9806 Da

Subunit: Interacts with IDE and INS. Can form homodimers. Interaction with INS inhibits homodimerization and fibril

formation

Subcellular location: Secreted

Mass spectrometry: Mass=3936; Method=MALDI; Range=34-70; Source=PubMed:17374526;

Miscellaneous: IAPP is the peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in

insulinomas

6/13 PDB 3D structures from and Proteopedia for IAPP (see all 13):

1KUW (3D)

2G48 (3D)

2KB8 (3D)

2L86 (3D)

3FPO (3D)

3FR1 (3D)

Secondary accessions: Q0ZD87 Q14598

Explore the universe of human proteins at neXtProt for IAPP: NX_P10997

Post-translational modifications:

Amyloid fibrils are degraded by IDE¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P10997

IAPP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000406.1

ENSEMBL proteins:

ENSP00000437357 ENSP00000240652 ENSP00000445711 ENSP00000445980 ENSP00000437559

Reactome Protein details: P10997
Human Recombinant Protein Products:

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	Uscn Proteins for IAPP

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0005625	soluble fraction	--	--
GO:0043025	neuronal cell body	IEA	--

IAPP for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for IAPP

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

IAPP for domains About GeneDecksing

5 InterPro domains/families:

IPR018360 Calcitonin_CS

IPR001693 Calcitonin_peptide-like

IPR000443 Pro-islet_amyloid_polypep

IPR021116 Procalcitonin/adrenomedullin

IPR021117 Procalcitonin-like

Graphical View of Domain Structure for InterPro Entry P10997

ProtoNet protein and cluster: P10997

1 Blocks protein family: IPB000443 Islet amyloid protein (amylin) signature

UniProtKB/Swiss-Prot: IAPP_HUMAN, P10997

Domain: The mature protein is largely unstructured in the absence of a cognate ligand, and has a strong tendency to

form fibrillar aggregates. Homodimerization may be the first step of amyloid formation

Similarity: Belongs to the calcitonin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: IAPP_HUMAN, P10997

Function: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not

affecting adipocyte glucose metabolism

Genatlas biochemistry entry for IAPP:

islet amyloid polypeptide

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IAPP

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	TAS	2608057
GO:0005179	hormone activity	IEA	--

IAPP for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Iapp^tm1Sgm for IAPP
     5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Iapp):

growth/size

hematopoietic system

homeostasis/metabolism

immune system

skeleton

IAPP for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Regulation of beta-cell development

	Regulation of beta-cell development	1.00			Regulation of gene expression in beta cells	0.56
	Maturity onset diabetes of the young	0.56

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Amyloid precursor proteins form ordered fibrils

Amyloid precursor proteins form ordered fibrils

1.00

Amyloids

0.43

Integrated Pancreatic Cancer Pathway

Integrated Pancreatic Cancer Pathway

1.00

Integrated Pancreatic Cancer Pathway

0.99

G beta:gamma signalling through PLC beta

Class B/2 (Secretin family receptors)

0.20

G alpha (s) signalling events

0.14

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for IAPP

	Selected targets of CREB1
	Selected targets of HNF1

2 BioSystems Pathways for IAPP

	Integrated Pancreatic Cancer Pathway
	Integrated Pancreatic Cancer Pathway

5/14 Reactome Pathways for IAPP (see all 14)

	GPCR downstream signaling
	Developmental Biology
	Regulation of beta-cell development
	Signaling by GPCR
	GPCR ligand binding

1 Kegg Pathway (Kegg details for IAPP):

Maturity onset diabetes of the young

IAPP for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for IAPP

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/93 Interacting proteins for IAPP (P10997³ ENSP00000240652⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 93)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RAMP2	O60895³, ENSP00000253796⁴	I2D: score=2 STRING: ENSP00000253796
PCSK1	P29120³, ENSP00000308024⁴	I2D: score=1 STRING: ENSP00000308024
PDX1	P52945³, ENSP00000370421⁴	I2D: score=1 STRING: ENSP00000370421
PCSK2	P16519³, ENSP00000262545⁴	I2D: score=1 STRING: ENSP00000262545
RAMP1	O60894³, ENSP00000254661⁴	I2D: score=1 STRING: ENSP00000254661

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	TAS	8152488
GO:0007165	signal transduction	TAS	10342886
GO:0007267	cell-cell signaling	TAS	2608057
GO:0019233	sensory perception of pain	IEA	--
GO:0031018	endocrine pancreas development	TAS	--

IAPP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

IAPP for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for IAPP
10/73 Novoseek chemical compound relationships for IAPP gene (see all 73) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pramlintide	97.4	150	12534323 (13), 11763160 (4), 11979398 (3), 11472273 (3) (see all 81)
i-app	95.7	354	10907112 (10), 19475663 (7), 7935487 (7), 1541234 (6) (see all 99)
ac 187	87.1	7	8882637 (2), 10433998 (1), 12611974 (1), 16492540 (1)
exenatide	83.8	23	14725490 (4), 14992323 (1), 16625817 (1), 17272793 (1) (see all 14)
amylinamide	74.7	3	1646609 (3)
liraglutide	70.9	4	16625817 (1), 18794593 (1), 20234354 (1), 15340100 (1)
thioflavin t	69.9	5	9568695 (1), 16884500 (1), 11374584 (1), 19100955 (1)
glucose	69.2	294	10946889 (8), 1860552 (7), 8163050 (6), 1541239 (6) (see all 99)
incretin	66.5	13	17367252 (2), 7692203 (2), 16751350 (1), 17272793 (1) (see all 11)
c-peptide	65.9	41	9212327 (4), 20005261 (4), 15057546 (2), 18624122 (2) (see all 22)

Search CenterWatch for drugs/clinical trials and news about IAPP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for IAPP gene:

NM_000415.2

Unigene Cluster for IAPP:

Islet amyloid polypeptide

Hs.46835 [show with all ESTs]

Unigene Representative Sequence: NM_000415

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000539393 ENST00000240652(uc001rev.3) ENST00000542023 ENST00000537593

ENST00000535428

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Additional cDNA sequence:

DQ516082.1 J04422.1 X14904.1 X14905.1

6 DOTS entries:

DT.95293617 DT.121183677 DT.100779782 DT.100779779 DT.99931396 DT.92435879

24/300 AceView cDNA sequences (see all 300):

BU071178 BQ417003 BU947587 CA942651 BI712710 BM314356 BM353731 BI324887

BQ478162 BU782763 BM504821 AW584023 CA952530 BU069957 BM263836 X14905

BG654456 CB068861 BI324997 CB177247 BU786844 BM314519 BM857649 CB068471

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for IAPP About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4a	·	4b
SP1:					-				-
SP2:					-
SP3:									-

ECgene alternative splicing isoforms for IAPP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

IAPP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

IAPP expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Skeletal Muscle

Hyoid Arch Muscles

Mononuclear Myocytes

Skeletal Muscle

Mandibular Arch Muscles

Mononuclear Myocytes

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See IAPP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IAPP

SOURCE GeneReport for Unigene cluster: Hs.46835

SABiosciences Expression via Pathway-Focused PCR Arrays including IAPP:

Terminal Differentiation Markers in human mouse rat

Obesity in human mouse rat

Embryonic Stem Cells in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IAPP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for IAPP gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Iapp^{1 , 5}	islet amyloid polypeptide^{1, 5}	76.25(n)¹ 68.97(a)¹		6 (73.81 cM)⁵ 15874¹ NM_010491.2¹ NP_034621.1¹ 142298423⁵
chicken (Gallus gallus)	Aves	Q90743_CHICK⁶	islet amyloid polypeptide	44(a)	1 ↔ 1	1(67422425-67426340)
lizard (Anolis carolinensis)	Reptilia	IAPP⁶	--	41(a)	1 ↔ 1	5(8299642-8304684)
zebrafish (Danio rerio)	Actinopterygii	CABZ01044574.1⁶	--	35(a)	1 ↔ 1	5(62661681-62676468)

ENSEMBL Gene Tree for IAPP (if available)
TreeFam Gene Tree for IAPP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12314260^1,2	A,	--	21523943(+)	`ctgctA/Cctgca`	2	--	int¹ us2k¹		0	--	--	--	--
rs193015051^1,2		--	21523995(+)	`GGTTTC/TGCAGT`	2	--	int¹ us2k¹		0	--	--	--	--
rs182709883^1,2		--	21524027(+)	`CTACAC/TGCAGA`	2	--	us2k¹ int¹		0	--	--	--	--
rs187122840^1,2		--	21524050(+)	`TTATGC/TGGAAA`	2	--	int¹ us2k¹		0	--	--	--	--
rs11046005^1,2	C,F,A,	--	21524077(+)	`AGTAAT/CTTTTG`	2	--	int¹ us2k¹		10		NA WA CSA EA	371
rs73080816^1,2	C,	--	21524141(+)	`GCAATG/AGTAAA`	2	--	us2k¹ int¹		2		NA WA	120
rs191539713^1,2		--	21524159(+)	`GGCACA/GCTAGG`	2	--	int¹ us2k¹		0	--	--	--	--
rs183725400^1,2		--	21524198(+)	`ATTGGC/TCCTGT`	2	--	us2k¹ int¹		0	--	--	--	--
rs117091430^1,2		--	21524243(+)	`CCCTGC/TCTCTG`	2	--	us2k¹ int¹		1		NA	120
rs114193563^1,2	F,	--	21524306(+)	`CTTACG/AGAAAT`	2	--	int¹ us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for IAPP (21507893 - 21532914 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for IAPP
2 CNVs: 49027 49026
Human Gene Mutation Database (HGMD): IAPP

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IAPP

DNA2.0 Custom Variant and Variant Library Synthesis for IAPP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

IAPP for disorders           About GeneDecksing

OMIM gene information: 147940    OMIM disorders: --

20/59 diseases for IAPP (see all 59):    About MalaCards

insulinoma diabetes mellitus nasu-hakola disease alzheimer's disease

pancreatitis islet cell tumor maturity-onset diabetes of the young glucose intolerance

pancreatic islet cell tumors type 2 diabetes mellitus type 1 diabetes mellitus hypocalcemia

insulin resistance carcinoid tumors essential hypertension metabolic disorders

anorexia nervosa hypercalcemia morbid obesity gestational diabetes

6 diseases from the University of Copenhagen DISEASES database for IAPP:

Diabetes mellitus Hyperglycemia Amyloidosis Alzheimer's disease

Pancreatic cancer Hypoglycemia

10/61 Novoseek disease relationships for IAPP gene (see all 61) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
niddm	77.2	113	9589246 (4), 12534323 (4), 7705017 (3), 1950379 (3) (see all 63)
hyperglycemia	68.6	31	8842609 (2), 1534057 (1), 16492545 (1), 17617279 (1) (see all 24)
amyloid deposition	66.8	14	1541234 (2), 8111613 (1), 12941771 (1), 12706321 (1) (see all 11)
hyperglucagonemia	63.6	5	12384827 (2), 8842609 (2), 11979398 (1)
insulinoma	62.7	28	8317551 (3), 14507315 (3), 12941771 (2), 9166666 (1) (see all 19)
insulin resistance	61.1	52	8967027 (3), 8877314 (2), 2204154 (2), 9814997 (2) (see all 39)
hypoglycemia	60.6	12	16492545 (2), 1787825 (2), 16492543 (2), 8772580 (1) (see all 8)
diabetes mellitus	57	36	8152488 (2), 11772274 (2), 1737562 (1), 7594773 (1) (see all 31)
amyloidosis	56.3	13	9568695 (2), 19266159 (1), 15878744 (1), 8296225 (1) (see all 12)
impaired glucose tolerance	52.8	14	10946889 (4), 9568698 (2), 1756902 (1), 8877314 (1) (see all 8)

Genetic Association Database (GAD): IAPP
Human Genome Epidemiology (HuGE) Navigator: IAPP (13 documents)

Export disorders for IAPP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for IAPP gene, integrated from 9 sources (see all 756):
(articles sorted by number of sources associating them with IAPP)

Utopia: connect your pdf to the dynamic
world of online information

Missense mutation of amylin gene (S20G) in Japanese NIDDM patients. (PubMed id 8772735)^{1, 2, 4, 9} Sakagashira S.... Nanjo K. (1996)
Characterization of the human islet amyloid polypeptide/amylin gene transcripts: identification of a new polyadenylation site. (PubMed id 1282806)^{1, 2, 9} Hoeppener J.W.M....Jansz H.S. (1992)
Islet amyloid polypeptide: structure and upstream sequences of the IAPP gene in rat and man. (PubMed id 2223885)^{1, 2, 9} van Mansfeld A.D.M.... Jansz H.S. (1990)
Islet amyloid polypeptide gene promoter polymorphisms are not associated with Type 2 diabetes or with the severity of islet amyloidosis. (PubMed id 15878744)^{1, 4, 9} Esapa C....Clark A. (2005)
Cloning and expression of human islet amyloid polypeptide in cultured cells. (PubMed id 17374526)^{1, 2, 9} Bhattacharya S.... Singh S. (2007)
S20G mutation of the amylin gene is associated with a lower body mass index in Korean type 2 diabetic patients. (PubMed id 12706321)^{1, 4, 9} Cho Y.M....Lee H.K. (2003)
Polymorphism in intron 2 of islet amyloid polypeptide gene is associated with lower low-density lipoprotein cholesterol in nondiabetic subjects and in type 2 diabetic patients. (PubMed id 12588049)^{1, 4, 9} Rojas I....Novials A. (2002)
Solution structures of calcitonin-gene-related-peptide analogues of calcitonin-gene-related peptide and amylin. (PubMed id 2039456)^{1, 2, 9} Hubbard J.A.M....Price N.C. (1991)
Dynamic alpha-helix structure of micelle-bound human amylin. (PubMed id 19244249)^{1, 2} Patil S.M.... Alexandrescu A.T. (2009)
Amylin gene promoter mutations predispose to Type 2 diabetes in New Zealand Maori. (PubMed id 12679865)^{1, 4} Poa N.R....Edgar P.F. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3375	HGNC: 5329	AceView: IAPP	Ensembl:ENSG00000121351	euGenes: HUgn3375
ECgene: IAPP	Kegg: 3375	H-InvDB: IAPP

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for IAPP	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Amylin

Intellectual Property for IAPP gene
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Patent Information for IAPP gene:
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GeneCards and IP:
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Hypocalcemia
BREAST CARCINOMA
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islet amyloid polypeptide

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