Aliases for IAPP Gene
External Ids for IAPP Gene
Previous GeneCards Identifiers for IAPP Gene
The protein encoded by this gene is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. Studies suggest that this protein, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. This protein also exhibits an bactericidal, antimicrobial activity. [provided by RefSeq, Sep 2014]
GeneCards Summary for IAPP Gene
IAPP (Islet Amyloid Polypeptide) is a Protein Coding gene. Diseases associated with IAPP include Insulinoma and Islet Cell Tumor. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Integrated Pancreatic Cancer Pathway. GO annotations related to this gene include identical protein binding and hormone activity.
UniProtKB/Swiss-Prot for IAPP Gene
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.