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Aliases for IAH1 Gene

Aliases for IAH1 Gene

  • Isoamyl Acetate-Hydrolyzing Esterase 1 Homolog 2 3 5
  • Isoamyl Acetate-Hydrolyzing Esterase 1 Homolog (S. Cerevisiae) 2
  • EC 3.1.-.- 4

External Ids for IAH1 Gene

Previous GeneCards Identifiers for IAH1 Gene

  • GC02P009533
  • GC02P009613

Summaries for IAH1 Gene

GeneCards Summary for IAH1 Gene

IAH1 (Isoamyl Acetate-Hydrolyzing Esterase 1 Homolog) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity and hydrolase activity, acting on ester bonds.

UniProtKB/Swiss-Prot for IAH1 Gene

  • Probable lipase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IAH1 Gene

Genomics for IAH1 Gene

Regulatory Elements for IAH1 Gene

Promoters for IAH1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IAH1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IAH1 Gene

Chromosome:
2
Start:
9,473,658 bp from pter
End:
9,517,208 bp from pter
Size:
43,551 bases
Orientation:
Plus strand

Genomic View for IAH1 Gene

Genes around IAH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IAH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IAH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IAH1 Gene

Proteins for IAH1 Gene

  • Protein details for IAH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2TAA2-IAH1_HUMAN
    Recommended name:
    Isoamyl acetate-hydrolyzing esterase 1 homolog
    Protein Accession:
    Q2TAA2
    Secondary Accessions:
    • B4DMV3

    Protein attributes for IAH1 Gene

    Size:
    248 amino acids
    Molecular mass:
    27599 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IAH1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IAH1 Gene

Proteomics data for IAH1 Gene at MOPED

Post-translational modifications for IAH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for IAH1

No data available for DME Specific Peptides for IAH1 Gene

Domains & Families for IAH1 Gene

Protein Domains for IAH1 Gene

Graphical View of Domain Structure for InterPro Entry

Q2TAA2

UniProtKB/Swiss-Prot:

IAH1_HUMAN :
  • Belongs to the GDSL lipolytic enzyme family. IAH1 subfamily.
Family:
  • Belongs to the GDSL lipolytic enzyme family. IAH1 subfamily.
genes like me logo Genes that share domains with IAH1: view

No data available for Gene Families for IAH1 Gene

Function for IAH1 Gene

Molecular function for IAH1 Gene

UniProtKB/Swiss-Prot Function:
Probable lipase.

Enzyme Numbers (IUBMB) for IAH1 Gene

Gene Ontology (GO) - Molecular Function for IAH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016788 hydrolase activity, acting on ester bonds IEA --
genes like me logo Genes that share ontologies with IAH1: view

Phenotypes for IAH1 Gene

genes like me logo Genes that share phenotypes with IAH1: view

Animal Models for IAH1 Gene

MGI Knock Outs for IAH1:
  • Iah1 tm1b(EUCOMM)Hmgu

Animal Model Products

  • Taconic Biosciences Mouse Models for IAH1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IAH1 Gene

Localization for IAH1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IAH1 Gene COMPARTMENTS Subcellular localization image for IAH1 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IAH1 Gene

Pathways & Interactions for IAH1 Gene

SuperPathways for IAH1 Gene

No Data Available

Interacting Proteins for IAH1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000417580%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q2TAA2-IAH1_HUMAN ENSP00000417580 for IAH1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for IAH1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IAH1 Gene

Drugs & Compounds for IAH1 Gene

No Compound Related Data Available

Transcripts for IAH1 Gene

mRNA/cDNA for IAH1 Gene

(6) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IAH1 Gene

Isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IAH1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f
SP1: - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - -
SP10: -
SP11: - -

Relevant External Links for IAH1 Gene

GeneLoc Exon Structure for
IAH1
ECgene alternative splicing isoforms for
IAH1

Expression for IAH1 Gene

mRNA expression in normal human tissues for IAH1 Gene

Protein differential expression in normal tissues from HIPED for IAH1 Gene

This gene is overexpressed in Serum (13.3) and Uterus (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for IAH1 Gene



SOURCE GeneReport for Unigene cluster for IAH1 Gene Hs.744980

genes like me logo Genes that share expression patterns with IAH1: view

Protein tissue co-expression partners for IAH1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IAH1 Gene

Orthologs for IAH1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IAH1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IAH1 35
  • 82.26 (n)
  • 85.48 (a)
IAH1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IAH1 35
  • 85.75 (n)
  • 90.73 (a)
IAH1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Iah1 35
  • 82.8 (n)
  • 83.87 (a)
Iah1 16
Iah1 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IAH1 35
  • 99.6 (n)
  • 100 (a)
IAH1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Iah1 35
  • 81.45 (n)
  • 83.06 (a)
oppossum
(Monodelphis domestica)
Mammalia IAH1 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IAH1 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves IAH1 35
  • 70.49 (n)
  • 72.13 (a)
IAH1 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IAH1 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia iah1 35
  • 67.25 (n)
  • 64.63 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.14991 35
iah1 35
  • 61.45 (n)
  • 61.3 (a)
iah1 36
  • 60 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10296 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes IAH1 36
  • 33 (a)
OneToOne
IAH1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G45920 35
  • 48.42 (n)
  • 45.25 (a)
rice
(Oryza sativa)
Liliopsida Os01g0214200 35
  • 52.1 (n)
  • 47.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8601 36
  • 40 (a)
OneToOne
Species with no ortholog for IAH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IAH1 Gene

ENSEMBL:
Gene Tree for IAH1 (if available)
TreeFam:
Gene Tree for IAH1 (if available)

Paralogs for IAH1 Gene

No data available for Paralogs for IAH1 Gene

Variants for IAH1 Gene

Sequence variations from dbSNP and Humsavar for IAH1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1251 -- 9,488,692(+) TTCCA(A/G)AAGTG intron-variant, downstream-variant-500B
rs1129766 -- 9,474,641(+) TCCAT(A/C)ACCCA nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon
rs1815892 -- 9,476,599(+) GGGTA(G/T)GGCAG intron-variant
rs1815894 -- 9,487,358(-) TTAGG(C/T)AGAAA intron-variant
rs2276337 -- 9,481,554(-) CATAC(C/T)GAGCC intron-variant

Variation tolerance for IAH1 Gene

Residual Variation Intolerance Score: 48.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.81; 34.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IAH1 Gene

HapMap Linkage Disequilibrium report
IAH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IAH1 Gene

Disorders for IAH1 Gene

Relevant External Links for IAH1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IAH1

No disorders were found for IAH1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IAH1 Gene

Publications for IAH1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality. (PMID: 24159190) SeppAolAo I. … LehtimAoki T. (Eur. Heart J. 2014) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for IAH1 Gene

Sources for IAH1 Gene

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