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IAH1 Gene

protein-coding GIFtS: 38

GC02P009533

isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.1.-.- ^³
MGC102860 ^²

Descriptions
isoamyl acetate-hydrolyzing esterase 1 homolog ^²
isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae) ^²

External Ids
HGNC: 27696¹
Entrez Gene: 285148²
UniProtKB: Q2TAA2³
Ensembl: ENSG00000134330⁷

Search outside databases for aliases for IAH1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: IAH1_HUMAN, Q2TAA2

Function: Probable lipase (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.1 Ensembl cytogenetic band: 2p25.1 HGNC cytogenetic band: 2p25.1

IAH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P009533: (about GC identifiers)

Start:	9,532,116 bp from pter
End:	9,546,201 bp from pter
Size:	14,086 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_005334.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: IAH1_HUMAN, Q2TAA2 (See protein sequence)

Recommended Name: Isoamyl acetate-hydrolyzing esterase 1 homolog

Size: 248 amino acids; 27599 Da

REFSEQ proteins: NP_001034702.1

ENSEMBL proteins:

ENSP00000382060 ENSP00000314400

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: IAH1

Antibodies for IAH1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for IAH1

Assays for IAH1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q2TAA2

ProtoNet protein and cluster: Q2TAA2

1 Blocks protein family: IPB001087 Lipolytic enzyme

UniProtKB/Swiss-Prot: IAH1_HUMAN, Q2TAA2

Similarity: Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001039613

Applied Biosystems Silencer® siRNAs for IAH1

Sigma-Aldrich siRNA for IAH1

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001039613
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001039613
untagged cDNA clone in CMV expression vector: NM_001039613

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001039613

UniProtKB/Swiss-Prot: IAH1_HUMAN, Q2TAA2

Function: Probable lipase (By similarity)

Enzyme Number (IUBMB): EC 3.1.-.-

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016788	hydrolase activity, acting on ester bonds	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016042	lipid catabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for IAH1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001039613

Sigma-Aldrich siRNA for IAH1

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001039613

REFSEQ mRNAs for IAH1 gene:

NM_001039613.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001039613

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001039613
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001039613
                                 untagged cDNA clone in CMV expression vector: NM_001039613

Additional cDNA sequence:

AK074513.1 AK092982.1 AK291984.1 AK297648.1 BC019061.1 BC039709.1 BC059410.1 BC067865.1

BC111025.1 CR621865.1

9 DOTS entries:

DT.99954967 DT.97840889 DT.100027352 DT.100785393 DT.91750056 DT.92425569 DT.97843151 DT.99950019

DT.99966454

highest scoring ESTs for IAH1:

AA042960 AA249311 AA482972 AA496151 AA524357 AA533526 AA553874 AA657408 AA683334 AA743945

Unigene Cluster for IAH1:

Isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae)

Hs.614939 [show with all ESTs]

Unigene Representative Sequence: AK092982

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for IAH1 (see all 11 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8a	·	8b	·	8c	·	8d	^	9	^	10a	·	10b	·	10c	·	10d	·	10e	·	10f
SP1:					-		-		-		-		-		-								-										-		-
SP2:									-		-		-		-								-										-		-
SP3:									-		-		-		-				-				-										-		-
SP4:													-		-								-										-
SP5:															-								-										-		-

About this scheme

ECgene alternative splicing isoforms for IAH1

2 Ensembl transcripts including schematic representations:

ENST00000399109 ENST00000351760

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

IAH1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for IAH1

¹ / ² / ³

4 probe-sets matching IAH1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
230621_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AA502936	0.40	1.00	0.76	1
225908_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI829927	0.60	1.00	0.82	1
230621_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
225908_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGCAGTACC

SOURCE GeneReport for Unigene cluster: Hs.614939

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for IAH1 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	IAH1¹	--	isoamyl acetate-hydrolyzing esterase 1 homolog (S. more	85.75(n) 90.73(a)	609656 XM_846956.1 XP_852049.1
chimpanzee (Pan troglodytes)	IAH1¹	--	isoamyl acetate-hydrolyzing esterase 1 homolog (S. more	99.6(n) 100(a)	744315 XM_001155422.1 XP_001155422.1
cow (Bos taurus)	IAH1¹	--	isoamyl acetate-hydrolyzing esterase 1 homolog (S. more	82.26(n) 85.48(a)	614320 NM_001034758.1 NP_001029930.1
rat (Rattus norvegicus)	Iah1¹	--	isoamyl acetate-hydrolyzing esterase 1 homolog (S. more	81.45(n) 83.06(a)	298917 XM_216665.4 XP_216665.3
mouse (Mus musculus)	Iah1^{1, 5}	12⁵	isoamyl acetate-hydrolyzing esterase 1 homolog (S. more^{1, 5}	82.8(n)¹ 83.87(a)¹	67732¹ NM_026347.3¹ NP_080623.2¹ AI837665⁵ AK005287⁵ (see all 12)

About this table Species with no ortholog for IAH1

ENSEMBL Gene Tree for IAH1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/98 NCBI SNPs in IAH1 are shown (see all 98 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 56)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1251^1,2	C,H,O	9546272(+)	`TTCCAA/GAAGTG`	1	--	ng3¹ ese³		10		MN NA EU EA WA	924
	rs13411809^1,2	C	9531974(+)	`GGTGAA/GCAAGC`	1	--	ng5¹		0	--	--	--	--
	rs7591166^1,2	A,C,F,H	9533486(+)	`AAAACA/GGAAGT`	1	--	int¹		4		EU EA WA	416
	rs6432011^1,2	A,C,F,H	9542900(+)	`GAAGGC/TTACTT`	1	--	int¹		8		EU EA WA	836
	rs4511696^1,2	A,C,F,H	9537228(+)	`GAACTC/GTTACA`	1	--	int¹		4		EU EA WA	420
--	rs1815892^1,2	A,C,F,H	9534179(+)	`gggtaG/Tggcag`	1	--	int¹		4		EU EA WA	420
	rs4319913^1,2	A,C,F,H	9543433(+)	`GGCTAC/TTTCAT`	1	--	int¹		8		EU EA WA	836
	rs2276337^1,2	C,F,H,O	9539134(-)	`CATACC/TGAGCC`	1	--	int¹		8		EA NA EU WA	2020
	rs7561588^1,2	A,C,F,H	9536655(+)	`ATGAAG/AGAACA`	1	--	int¹		4		EU EA WA	418
	rs6747070^1,2	A,C,F,H	9538181(+)	`aagacC/Tggaaa`	1	--	int¹		8		EU EA WA	838

About this table

HapMap Linkage Disequilibrium images for IAH1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

3 PubMed articles for IAH1 gene:

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 285148	HGNC: 27696	Ensembl:ENSG00000134330	euGenes: HUgn285148	ECgene: IAH1
H-InvDB: IAH1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for IAH1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for IAH1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for IAH1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for IAH1		Browse antibodies at Sigma-Aldrich
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	Browse shRNAs at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
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	Recombinant & Natural Proteins

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	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for IAH1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for IAH1

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IAH1 Gene

protein-coding GIFtS: 38

Aliases &
Descriptions
for IAH1

Summaries
for IAH1

Genomic Location
for IAH1

Proteins
for IAH1

Protein Domains/
Families
for IAH1

Gene Function
for IAH1

Pathways & Interactions
for IAH1

Drugs & Compounds
for IAH1

Transcripts
for IAH1

Expression
for IAH1

Orthologs
for IAH1

Paralogs
for IAH1

SNPs/Variants
for IAH1

Disorders & Mutations
for IAH1

Medical News
for IAH1

Publications
for IAH1

Search for IAH1

Genome Databases showing IAH1

Other Databases showing IAH1

Specialized Databases showing IAH1

Licensable Technologies
for IAH1

Services
for IAH1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

IAH1 Gene

protein-coding GIFtS: 38

Aliases & Descriptionsfor IAH1

Summariesfor IAH1

Genomic Locationfor IAH1

Proteinsfor IAH1

Protein Domains/Familiesfor IAH1

Gene Functionfor IAH1

Pathways & Interactionsfor IAH1

Drugs & Compoundsfor IAH1

Transcriptsfor IAH1

Expression for IAH1

Orthologsfor IAH1

Paralogsfor IAH1

SNPs/Variantsfor IAH1

Disorders & Mutationsfor IAH1

Medical Newsfor IAH1

Publicationsfor IAH1

Search for IAH1

Genome Databases showing IAH1

Other Databases showing IAH1

Specialized Databases showing IAH1

Licensable Technologiesfor IAH1

Servicesfor IAH1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for IAH1

Summaries
for IAH1

Genomic Location
for IAH1

Proteins
for IAH1

Protein Domains/
Families
for IAH1

Gene Function
for IAH1

Pathways & Interactions
for IAH1

Drugs & Compounds
for IAH1

Transcripts
for IAH1

Expression
for IAH1

Orthologs
for IAH1

Paralogs
for IAH1

SNPs/Variants
for IAH1

Disorders & Mutations
for IAH1

Medical News
for IAH1

Publications
for IAH1

Licensable Technologies
for IAH1

Services
for IAH1