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Aliases for HUWE1 Gene

Aliases for HUWE1 Gene

  • HECT, UBA And WWE Domain Containing 1, E3 Ubiquitin Protein Ligase 2 3 5
  • Homologous To E6AP Carboxyl Terminus Homologous Protein 9 3 4
  • Upstream Regulatory Element-Binding Protein 1 3 4
  • Mcl-1 Ubiquitin Ligase E3 3 4
  • Large Structure Of UREB1 3 4
  • ARF-Binding Protein 1 3 4
  • URE-Binding Protein 1 3 4
  • ARF-BP1 3 4
  • HECTH9 3 4
  • URE-B1 3 4
  • LASU1 3 4
  • UREB1 3 4
  • MULE 3 4
  • HECT, UBA And WWE Domain-Containing Protein 1 4
  • HECT, UBA And WWE Domain Containing 1 2
  • HECT Domain Protein LASU1 3
  • BJ-HCC-24 Tumor Antigen 3
  • EC 6.3.2.6 63
  • EC 6.3.2.- 4
  • KIAA0312 4
  • KIAA1578 4
  • EC 6.3.2 63
  • HSPC272 3
  • Ib772 3

External Ids for HUWE1 Gene

Previous GeneCards Identifiers for HUWE1 Gene

  • GC0XM053444
  • GC0XM053575
  • GC0XM050615
  • GC0XM053559

Summaries for HUWE1 Gene

Entrez Gene Summary for HUWE1 Gene

  • This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation. [provided by RefSeq, Aug 2013]

GeneCards Summary for HUWE1 Gene

HUWE1 (HECT, UBA And WWE Domain Containing 1, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Diseases associated with HUWE1 include Mental Retardation, X-Linked Syndromic, Turner Type and X-Linked Intellectual Disability, Turner Type. Among its related pathways are p53 Pathway (RnD) and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include poly(A) RNA binding and ligase activity. An important paralog of this gene is HERC2.

UniProtKB/Swiss-Prot for HUWE1 Gene

  • E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at Lys-41, Lys-61 and Lys-81, thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of isoform 2 of PA2G4.

Gene Wiki entry for HUWE1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HUWE1 Gene

Genomics for HUWE1 Gene

Regulatory Elements for HUWE1 Gene

Enhancers for HUWE1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HUWE1 on UCSC Golden Path with GeneCards custom track

Promoters for HUWE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HUWE1 on UCSC Golden Path with GeneCards custom track

Genomic Location for HUWE1 Gene

Chromosome:
X
Start:
53,532,096 bp from pter
End:
53,686,729 bp from pter
Size:
154,634 bases
Orientation:
Minus strand

Genomic View for HUWE1 Gene

Genes around HUWE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HUWE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HUWE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HUWE1 Gene

Proteins for HUWE1 Gene

  • Protein details for HUWE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6Z7-HUWE1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase HUWE1
    Protein Accession:
    Q7Z6Z7
    Secondary Accessions:
    • O15029
    • Q4G2Z2
    • Q5H961
    • Q6P4D0
    • Q8NG67
    • Q9BUI0
    • Q9HCJ4
    • Q9NSL6
    • Q9P0A9

    Protein attributes for HUWE1 Gene

    Size:
    4374 amino acids
    Molecular mass:
    481891 Da
    Quaternary structure:
    • Interacts with isoform p14ARF of CDKN2A which strongly inhibits HUWE1 ubiquitin ligase activity. Interacts with MYCN, POLB and CDC6. Interacts with isoform 2 of PA2G4.
    SequenceCaution:
    • Sequence=AAC62492.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF28950.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAF28950.1; Type=Frameshift; Positions=4356; Evidence={ECO:0000305}; Sequence=BAB13404.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA, contains the C-terminal part of ATP5I.; Evidence={ECO:0000305}; Sequence=BAC06833.1; Type=Frameshift; Positions=982, 1055; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HUWE1 Gene

    Alternative splice isoforms for HUWE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HUWE1 Gene

Proteomics data for HUWE1 Gene at MOPED

Selected DME Specific Peptides for HUWE1 Gene

Post-translational modifications for HUWE1 Gene

  • Phosphorylated on tyrosine; phosphorylation is probably required for its ability to inhibit TP53 transactivation.
  • Ubiquitination at Lys 173, Lys 190, Lys 324, Lys 342, Lys 632, Lys 674, Lys 1050, Lys 1107, Lys 1111, Lys 1147, Lys 1225, Lys 1295, Lys 1470, Lys 1608, Lys 1643, Lys 1702, Lys 1713, Lys 1917, Lys 1926, Lys 1931, Lys 2172, Lys 2219, Lys 2656, Lys 2671, Lys 3244, Lys 3274, Lys 3314, Lys 3345, Lys 3370, Lys 3409, Lys 3452, Lys 3558, Lys 3621, Lys 3675, Lys 3697, Lys 3954, Lys 4295, Lys 4305, and Lys 4322
  • Modification sites at PhosphoSitePlus

Other Protein References for HUWE1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HUWE1 (HUWE1)

Domains & Families for HUWE1 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z6Z7

UniProtKB/Swiss-Prot:

HUWE1_HUMAN :
  • The HECT domain mediates inhibition of the transcriptional activity of p53.
  • Belongs to the UPL family. TOM1/PTR1 subfamily.
Domain:
  • The HECT domain mediates inhibition of the transcriptional activity of p53.
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
  • Contains 1 UBA domain.
  • Contains 1 UIM (ubiquitin-interacting motif) domain.
  • Contains 1 WWE domain.
Family:
  • Belongs to the UPL family. TOM1/PTR1 subfamily.
genes like me logo Genes that share domains with HUWE1: view

No data available for Gene Families for HUWE1 Gene

Function for HUWE1 Gene

Molecular function for HUWE1 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at Lys-41, Lys-61 and Lys-81, thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of isoform 2 of PA2G4.

Enzyme Numbers (IUBMB) for HUWE1 Gene

Gene Ontology (GO) - Molecular Function for HUWE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA,TAS --
GO:0005488 binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with HUWE1: view
genes like me logo Genes that share phenotypes with HUWE1: view

Human Phenotype Ontology for HUWE1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HUWE1 Gene

MGI Knock Outs for HUWE1:

Animal Model Products

CRISPR Products

No data available for Transcription Factor Targets and HOMER Transcription for HUWE1 Gene

Localization for HUWE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HUWE1 Gene

Cytoplasm. Nucleus. Note=Mainly expressed in the cytoplasm of most tissues, except in the nucleus of spermatogonia, primary spermatocytes and neuronal cells (By similarity). Predominantly cytosolic or perinuclear in some colorectal carcinoma cells. {ECO:0000250 UniProtKB:Q7TMY8}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HUWE1 Gene COMPARTMENTS Subcellular localization image for HUWE1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for HUWE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19713937
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with HUWE1: view

Pathways & Interactions for HUWE1 Gene

genes like me logo Genes that share pathways with HUWE1: view

Pathways by source for HUWE1 Gene

UniProtKB/Swiss-Prot Q7Z6Z7-HUWE1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for HUWE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0016574 histone ubiquitination IDA 15767685
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with HUWE1: view

No data available for SIGNOR curated interactions for HUWE1 Gene

Drugs & Compounds for HUWE1 Gene

(4) Drugs for HUWE1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(3) Additional Compounds for HUWE1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with HUWE1: view

Transcripts for HUWE1 Gene

Unigene Clusters for HUWE1 Gene

HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HUWE1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1:
SP2: -
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SP20: - - - - - - - - - - - - - - - - -
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ExUns: 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34a · 34b ^ 35 ^ 36a · 36b · 36c ^ 37 ^ 38a · 38b ^ 39 ^ 40a ·
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SP18: - -
SP19: -
SP20: - - - - - - - - - - - - - - - - - - - - - - - - - -
SP21:
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SP23:
SP24:

ExUns: 40b · 40c · 40d · 40e · 40f · 40g ^ 41 ^ 42 ^ 43a · 43b ^ 44a · 44b ^ 45a · 45b ^ 46a · 46b · 46c · 46d ^ 47a · 47b · 47c ^ 48a · 48b ^ 49a · 49b · 49c ^
SP1:
SP2:
SP3:
SP4: - -
SP5:
SP6: -
SP7: -
SP8:
SP9:
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SP11: -
SP12: - -
SP13: - - -
SP14:
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SP22:
SP23:
SP24:

ExUns: 50a · 50b · 50c · 50d ^ 51 ^ 52a · 52b · 52c ^ 53a · 53b · 53c ^ 54 ^ 55 ^ 56a · 56b ^ 57a · 57b ^ 58a ·
SP1:
SP2:
SP3:
SP4: - - - -
SP5: -
SP6:
SP7:
SP8:
SP9:
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SP23:
SP24:

Relevant External Links for HUWE1 Gene

GeneLoc Exon Structure for
HUWE1
ECgene alternative splicing isoforms for
HUWE1

Expression for HUWE1 Gene

mRNA expression in normal human tissues for HUWE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HUWE1 Gene

This gene is overexpressed in Fetal ovary (8.2) and Peripheral blood mononuclear cells (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HUWE1 Gene



SOURCE GeneReport for Unigene cluster for HUWE1 Gene Hs.136905

mRNA Expression by UniProt/SwissProt for HUWE1 Gene

Q7Z6Z7-HUWE1_HUMAN
Tissue specificity: Weakly expressed in heart, brain and placenta but not in other tissues. Expressed in a number of cell lines, predominantly in those from colorectal carcinomas.
genes like me logo Genes that share expression patterns with HUWE1: view

Protein tissue co-expression partners for HUWE1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for HUWE1 Gene

Orthologs for HUWE1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HUWE1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HUWE1 35
  • 94.17 (n)
  • 98.29 (a)
HUWE1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HUWE1 35
  • 94.63 (n)
  • 98.77 (a)
HUWE1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Huwe1 35
  • 91.99 (n)
  • 97.74 (a)
Huwe1 16
Huwe1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HUWE1 35
  • 98.83 (n)
  • 98.77 (a)
HUWE1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HUWE1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HUWE1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HUWE1 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia huwe1 35
  • 75.78 (n)
  • 88.77 (a)
Str.8208 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7108 35
zebrafish
(Danio rerio)
Actinopterygii Dr.18821 35
huwe1 35
  • 71.89 (n)
  • 82.18 (a)
huwe1 36
  • 77 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3798 35
fruit fly
(Drosophila melanogaster)
Insecta CG8184 35
  • 51.1 (n)
  • 45.83 (a)
CG8184 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea eel-1 36
  • 30 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TOM1 38
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.655 35
barley
(Hordeum vulgare)
Liliopsida Hv.5280 35
rice
(Oryza sativa)
Liliopsida Os.7856 35
corn
(Zea mays)
Liliopsida Zm.3978 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5451 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
-- 36
  • 76 (a)
OneToMany
Species with no ortholog for HUWE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HUWE1 Gene

ENSEMBL:
Gene Tree for HUWE1 (if available)
TreeFam:
Gene Tree for HUWE1 (if available)

Paralogs for HUWE1 Gene

Paralogs for HUWE1 Gene

Pseudogenes.org Pseudogenes for HUWE1 Gene

genes like me logo Genes that share paralogs with HUWE1: view

Variants for HUWE1 Gene

Sequence variations from dbSNP and Humsavar for HUWE1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_045670 Mental retardation, X-linked, syndromic, Turner type (MRXST)
VAR_045671 Mental retardation, X-linked, syndromic, Turner type (MRXST)
VAR_045672 Mental retardation, X-linked, syndromic, Turner type (MRXST)
rs41307640 - 53,627,451(+) TAGTA(C/T)TGGGT nc-transcript-variant, reference, missense
rs149215 -- 53,620,644(+) TAAAT(G/T)GATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HUWE1 Gene

Variant ID Type Subtype PubMed ID
nsv435891 CNV Deletion 17901297
esv2740175 CNV Deletion 23290073
nsv6910 CNV Loss 18451855

Variation tolerance for HUWE1 Gene

Residual Variation Intolerance Score: 0.148% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.42; 63.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HUWE1 Gene

Human Gene Mutation Database (HGMD)
HUWE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HUWE1 Gene

Disorders for HUWE1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for HUWE1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mental retardation, x-linked syndromic, turner type
  • mental retardation, x-linked, syndromic, turner type
x-linked intellectual disability, turner type
angelman syndrome
  • as
- elite association - COSMIC cancer census association via MalaCards
Search HUWE1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

HUWE1_HUMAN
  • Mental retardation, X-linked 17 (MRX17) [MIM:300705]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. {ECO:0000269 PubMed:18252223}. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal microduplication involving HSD17B10 and HUWE1 has been found in patients with mental retardation.
  • Mental retardation, X-linked, syndromic, Turner type (MRXST) [MIM:300706]: A syndrome characterized by the association of mental retardation with macrocephaly and variable contractures. {ECO:0000269 PubMed:18252223}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for HUWE1

Genetic Association Database (GAD)
HUWE1
Human Genome Epidemiology (HuGE) Navigator
HUWE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HUWE1
genes like me logo Genes that share disorders with HUWE1: view

No data available for Genatlas for HUWE1 Gene

Publications for HUWE1 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4 67
  2. ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. (PMID: 15989956) Chen D. … Gu W. (Cell 2005) 3 23
  3. Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis. (PMID: 15989957) Zhong Q. … Wang X. (Cell 2005) 3 23
  4. The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases. (PMID: 10998601) Jackson P.K. … Reimann J.D. (Trends Cell Biol. 2000) 2 3
  5. Cloning of a DNA binding protein that is a tyrosine kinase substrate and recognizes an upstream initiator-like sequence in the promoter of the preprodynorphin gene. (PMID: 7968380) Gu J. … Iadarola M.J. (Brain Res. Mol. Brain Res. 1994) 3 23

Products for HUWE1 Gene

Sources for HUWE1 Gene

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