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Aliases for HERPUD2 Gene

Aliases for HERPUD2 Gene

  • HERPUD Family Member 2 2 3 5
  • Homocysteine-Inducible, Endoplasmic Reticulum Stress-Inducible, Ubiquitin-Like Domain Member 2 2

External Ids for HERPUD2 Gene

Previous GeneCards Identifiers for HERPUD2 Gene

  • GC07M035638

Summaries for HERPUD2 Gene

GeneCards Summary for HERPUD2 Gene

HERPUD2 (HERPUD Family Member 2) is a Protein Coding gene. An important paralog of this gene is HERPUD1.

UniProtKB/Swiss-Prot for HERPUD2 Gene

  • Could be involved in the unfolded protein response (UPR) pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HERPUD2 Gene

Genomics for HERPUD2 Gene

Regulatory Elements for HERPUD2 Gene

Enhancers for HERPUD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F035689 0.7 FANTOM5 ENCODE 46.7 +1.4 1395 9.1 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF207 HERPUD2 LOC101930085 EEPD1 SEPT7 LOC101928421
GH07F035724 1.4 FANTOM5 Ensembl ENCODE 20.8 -32.3 -32293 7.1 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 YBX1 BMI1 RAD21 RFX5 EGR1 HERPUD2 SEPT7-AS1 SEPT7 LOC101930085 LOC100506725 GC07M035768
GH07F035715 0.5 ENCODE 20.5 -21.2 -21242 2.0 FOSL1 ZNF366 SCRT2 ZNF512 RAD21 LOC101930085 HERPUD2 SEPT7 SEPT7-AS1 LOC100506725 GC07M035768
GH07F035682 0.6 Ensembl 20.3 +13.5 13471 0.2 ZNF512 HERPUD2 LOC101930085 LOC101928421
GH07F035648 0.5 Ensembl ENCODE 20.3 +47.0 46963 0.5 TFAP4 SAP130 CEBPB CEBPG YY1 ZNF316 SCRT2 CEBPA NFE2 ZBTB33 LOC101930085 HERPUD2 LOC101928421
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HERPUD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HERPUD2 Gene

Chromosome:
7
Start:
35,632,659 bp from pter
End:
35,695,571 bp from pter
Size:
62,913 bases
Orientation:
Minus strand

Genomic View for HERPUD2 Gene

Genes around HERPUD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HERPUD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HERPUD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HERPUD2 Gene

Proteins for HERPUD2 Gene

  • Protein details for HERPUD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSE4-HERP2_HUMAN
    Recommended name:
    Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein
    Protein Accession:
    Q9BSE4
    Secondary Accessions:
    • A4D1Y8
    • Q9H6F9

    Protein attributes for HERPUD2 Gene

    Size:
    406 amino acids
    Molecular mass:
    45147 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HERPUD2 Gene

neXtProt entry for HERPUD2 Gene

Post-translational modifications for HERPUD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for HERPUD2
  • Santa Cruz Biotechnology (SCBT) Antibodies for HERPUD2

No data available for DME Specific Peptides for HERPUD2 Gene

Domains & Families for HERPUD2 Gene

Protein Domains for HERPUD2 Gene

Suggested Antigen Peptide Sequences for HERPUD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BSE4

UniProtKB/Swiss-Prot:

HERP2_HUMAN :
  • Contains 1 ubiquitin-like domain.
Domain:
  • Contains 1 ubiquitin-like domain.
genes like me logo Genes that share domains with HERPUD2: view

No data available for Gene Families for HERPUD2 Gene

Function for HERPUD2 Gene

Molecular function for HERPUD2 Gene

UniProtKB/Swiss-Prot Function:
Could be involved in the unfolded protein response (UPR) pathway.
genes like me logo Genes that share phenotypes with HERPUD2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HERPUD2 Gene

Localization for HERPUD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HERPUD2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HERPUD2 Gene COMPARTMENTS Subcellular localization image for HERPUD2 gene
Compartment Confidence
nucleus 3
cytosol 2
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for HERPUD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HERPUD2: view

Pathways & Interactions for HERPUD2 Gene

SuperPathways for HERPUD2 Gene

No Data Available

Interacting Proteins for HERPUD2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000310729%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000310729 Q9BSE4-HERP2_HUMAN for HERPUD2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for HERPUD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006986 response to unfolded protein IEA --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with HERPUD2: view

No data available for Pathways by source and SIGNOR curated interactions for HERPUD2 Gene

Transcripts for HERPUD2 Gene

Unigene Clusters for HERPUD2 Gene

HERPUD family member 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HERPUD2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1:
SP2: -
SP3:
SP4: - -
SP5: -
SP6: - - -
SP7: - - -
SP8: - -

Relevant External Links for HERPUD2 Gene

GeneLoc Exon Structure for
HERPUD2
ECgene alternative splicing isoforms for
HERPUD2

Expression for HERPUD2 Gene

mRNA expression in normal human tissues for HERPUD2 Gene

Protein differential expression in normal tissues from HIPED for HERPUD2 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HERPUD2 Gene



Protein tissue co-expression partners for HERPUD2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HERPUD2 Gene:

HERPUD2

SOURCE GeneReport for Unigene cluster for HERPUD2 Gene:

Hs.643051
genes like me logo Genes that share expression patterns with HERPUD2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HERPUD2 Gene

Orthologs for HERPUD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HERPUD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HERPUD2 34 35
  • 99.75 (n)
dog
(Canis familiaris)
Mammalia HERPUD2 34 35
  • 95.32 (n)
cow
(Bos Taurus)
Mammalia HERPUD2 34 35
  • 94.75 (n)
mouse
(Mus musculus)
Mammalia Herpud2 34 16 35
  • 89.85 (n)
rat
(Rattus norvegicus)
Mammalia Herpud2 34
  • 89.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HERPUD2 35
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HERPUD2 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves HERPUD2 34 35
  • 76.05 (n)
lizard
(Anolis carolinensis)
Reptilia HERPUD2 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia herpud2 34
  • 65.83 (n)
Str.6501 34
African clawed frog
(Xenopus laevis)
Amphibia MGC52715 34
zebrafish
(Danio rerio)
Actinopterygii herpud2 34 35
  • 61 (n)
zgc56020 34
fruit fly
(Drosophila melanogaster)
Insecta Herp 34 35
  • 47.46 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3209 35
  • 35 (a)
OneToMany
Species where no ortholog for HERPUD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HERPUD2 Gene

ENSEMBL:
Gene Tree for HERPUD2 (if available)
TreeFam:
Gene Tree for HERPUD2 (if available)

Paralogs for HERPUD2 Gene

Paralogs for HERPUD2 Gene

(1) SIMAP similar genes for HERPUD2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with HERPUD2: view

Variants for HERPUD2 Gene

Sequence variations from dbSNP and Humsavar for HERPUD2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10046484 -- 35,691,462(+) CAAAG(C/T)CCCTC intron-variant
rs10085409 -- 35,667,777(+) AAACT(G/T)CTTAA intron-variant
rs10085483 -- 35,669,520(+) CAAAG(A/G)TGTCA intron-variant
rs10085633 -- 35,670,014(+) GTGAA(C/T)AGACT intron-variant
rs10224743 -- 35,659,553(+) ccaca(C/T)agaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HERPUD2 Gene

Variant ID Type Subtype PubMed ID
dgv419n21 CNV gain 19592680
esv1619444 CNV deletion 17803354
esv2659669 CNV deletion 23128226
esv3612818 CNV loss 21293372
nsv1026491 CNV gain 25217958
nsv1117707 CNV deletion 24896259
nsv1148532 CNV insertion 26484159
nsv471638 CNV gain 15918152
nsv475968 CNV novel sequence insertion 20440878
nsv527371 CNV gain 19592680
nsv5697 CNV deletion 18451855
nsv5699 CNV insertion 18451855

Variation tolerance for HERPUD2 Gene

Residual Variation Intolerance Score: 44.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.48; 91.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HERPUD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HERPUD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HERPUD2 Gene

Disorders for HERPUD2 Gene

Relevant External Links for HERPUD2

Genetic Association Database (GAD)
HERPUD2
Human Genome Epidemiology (HuGE) Navigator
HERPUD2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HERPUD2

No disorders were found for HERPUD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HERPUD2 Gene

Publications for HERPUD2 Gene

  1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. Heritability and genetic association analysis of cognition in theA Diabetes Heart Study. (PMID: 24684796) Cox A.J. … Bowden D.W. (Neurobiol. Aging 2014) 3 64

Products for HERPUD2 Gene

Sources for HERPUD2 Gene

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