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Aliases for HYPM Gene

Aliases for HYPM Gene

  • Huntingtin Interacting Protein M 2 3 5
  • Huntingtin Yeast Partner M 3 4
  • CXorf27 3 4
  • Chromosome X Open Reading Frame 27 2
  • HIP17 3

External Ids for HYPM Gene

Previous HGNC Symbols for HYPM Gene

  • CXorf27

Previous GeneCards Identifiers for HYPM Gene

  • GC0XP035955
  • GC0XP036137
  • GC0XP036694
  • GC0XP036880

Summaries for HYPM Gene

Entrez Gene Summary for HYPM Gene

  • This gene encodes a protein shown to interact with huntingtin, which contains an expanded polyglutamine tract in individuals with Huntington's disease (PMID: 9700202). [provided by RefSeq, Aug 2011]

GeneCards Summary for HYPM Gene

HYPM (Huntingtin Interacting Protein M) is a Protein Coding gene. GO annotations related to this gene include protein heterodimerization activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HYPM Gene

Genomics for HYPM Gene

Regulatory Elements for HYPM Gene

Enhancers for HYPM Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HYPM on UCSC Golden Path with GeneCards custom track

Genomic Location for HYPM Gene

37,990,817 bp from pter
37,991,317 bp from pter
501 bases
Plus strand

Genomic View for HYPM Gene

Genes around HYPM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HYPM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HYPM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HYPM Gene

Proteins for HYPM Gene

  • Protein details for HYPM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Huntingtin-interacting protein M
    Protein Accession:
    Secondary Accessions:
    • A1A4D3

    Protein attributes for HYPM Gene

    117 amino acids
    Molecular mass:
    13442 Da
    Quaternary structure:
    • May interact with the N-terminus of HD.
    • Sequence=AAC26851.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for HYPM Gene

Proteomics data for HYPM Gene at MOPED

Post-translational modifications for HYPM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HYPM Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HYPM Gene

Domains & Families for HYPM Gene

Protein Domains for HYPM Gene


Suggested Antigen Peptide Sequences for HYPM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HYPM: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HYPM Gene

Function for HYPM Gene

Gene Ontology (GO) - Molecular Function for HYPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA --
genes like me logo Genes that share ontologies with HYPM: view

Phenotypes for HYPM Gene

genes like me logo Genes that share phenotypes with HYPM: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HYPM Gene

Localization for HYPM Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for HYPM Gene

Pathways & Interactions for HYPM Gene

SuperPathways for HYPM Gene

No Data Available

Gene Ontology (GO) - Biological Process for HYPM Gene


No data available for Pathways by source and SIGNOR curated interactions for HYPM Gene

Drugs & Compounds for HYPM Gene

No Compound Related Data Available

Transcripts for HYPM Gene

mRNA/cDNA for HYPM Gene

(1) REFSEQ mRNAs :
(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for HYPM Gene

No ASD Table

Relevant External Links for HYPM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HYPM Gene

mRNA expression in normal human tissues for HYPM Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HYPM Gene

genes like me logo Genes that share expression patterns with HYPM: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HYPM Gene

Orthologs for HYPM Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for HYPM Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CXHXorf27 35
  • 99.43 (n)
  • 99.15 (a)
CXorf27 36
  • 99 (a)
(Mus musculus)
Mammalia 1700054O13Rik 36
  • 48 (a)
Species with no ortholog for HYPM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HYPM Gene

Gene Tree for HYPM (if available)
Gene Tree for HYPM (if available)

Paralogs for HYPM Gene

No data available for Paralogs for HYPM Gene

Variants for HYPM Gene

Sequence variations from dbSNP and Humsavar for HYPM Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_028810 -

Variation tolerance for HYPM Gene

Residual Variation Intolerance Score: 72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.46% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for HYPM Gene

Disorders for HYPM Gene

Relevant External Links for HYPM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HYPM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HYPM Gene

Publications for HYPM Gene

  1. Huntingtin interacts with a family of WW domain proteins. (PMID: 9700202) Faber P.W. … MacDonald M.E. (Hum. Mol. Genet. 1998) 2 3 4 67
  2. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Development and application of a DNA microarray-based yeast two-hybrid system. (PMID: 23275563) Suter B. … Wanker E.E. (Nucleic Acids Res. 2013) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for HYPM Gene

Sources for HYPM Gene