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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HYPK Gene

protein-coding   GIFtS: 38
GCID: GC15P044092

Huntingtin Interacting Protein K

(Previous name: chromosome 15 open reading frame 63)
(Previous symbol: C15orf63)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Huntingtin Interacting Protein K1 2     Huntingtin-Interacting Protein K2
C15orf631 2 3     EC 2.1.1.438
Huntingtin Yeast Partner K1 2 3     EC 2.7.7.68
Chromosome 15 Open Reading Frame 631     

External Ids:    HGNC: 184181   Entrez Gene: 257642   Ensembl: ENSG000002420287   OMIM: 6127845   UniProtKB: Q9NX553   

Export aliases for HYPK gene to outside databases

Previous GC identifers: GC15P039459 GC15P036988 GC15P041671 GC15P041808 GC15P041879 GC15P044070


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for HYPK Gene: 
HYPK (huntingtin interacting protein K) is a protein-coding gene. Diseases associated with HYPK include influenza, and neuronitis.

UniProtKB/Swiss-Prot: HYPK_HUMAN, Q9NX55
Function: Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT
polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10-NAA15 complex-mediated N-terminal
acetylation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.2  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HYPK gene promoter:
         AREB6   PPAR-alpha   NF-1   AML1a   Msx-1   Tal-1beta   ITF-2   Pax-4a   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHYPK promoter sequence
   Search SABiosciences Chromatin IP Primers for HYPK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HYPK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.3   Ensembl cytogenetic band:  15q15.3   HGNC cytogenetic band: 15q14

HYPK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HYPK gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P044092:  view genomic region     (about GC identifiers)

Start:
44,088,340 bp from pter      End:
44,095,241 bp from pter
Size:
6,902 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HYPK_HUMAN, Q9NX55 (See protein sequence)
Recommended Name: Huntingtin-interacting protein K  
Size: 129 amino acids; 14665 Da
Subunit: Interacts with HTT (via N-terminus). Associates with the NAA10-NAA15 complex and with the ribosome; the
NAA10-NAA15 complex is required for HYPK stability and for reducing polyQ aggregation of HTT. Interacts with
NAA15
Subcellular location: Nucleus. Cytoplasm
Sequence caution: Sequence=AAF29100.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA91165.1; Type=Miscellaneous discrepancy; Note=Readthrough transcript SERF2-HYPK/C15orf63;
Secondary accessions: C9JKJ0 O75408 Q8WUW8 Q9P024
Alternative splicing: 2 isoforms:  Q9NX55-2   Q9NX55-3   

Explore the universe of human proteins at neXtProt for HYPK: NX_Q9NX55

Explore proteomics data for HYPK at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NX55

  • 2 DME Specific Peptides for HYPK (Q9NX55)
     VSVAGSR  QEREKEL 

    HYPK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HYPK Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001186814.1  NP_057484.3  

    ENSEMBL proteins: 
     ENSP00000384474   ENSP00000401155   ENSP00000394060  

    Human Recombinant Protein Products for HYPK: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    HYPK for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9NX55


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HYPK_HUMAN, Q9NX55
    Function: Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT
    polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10-NAA15 complex-mediated N-terminal
    acetylation

         Enzyme Numbers (IUBMB): EC 2.1.1.432 EC 2.7.7.62

    Phenotypes:
         2 GenomeRNAi human phenotypes for HYPK:

     Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HYPK 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HYPK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/18 Interacting proteins for HYPK (Q9NX552, 3 ENSP000003844744) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NELFCDQ8IXH72, 3, ENSP000003423004MINT-64862 I2D: score=1 STRING: ENSP00000342300
    RBPMSQ930622, 3, ENSP000003401764MINT-67321 I2D: score=1 STRING: ENSP00000340176
    RHOXF2Q9BQY42, 3, ENSP000003604414MINT-66750 I2D: score=1 STRING: ENSP00000360441
    CHD3Q128732, 3MINT-65656 I2D: score=1 
    GCP027742, 3MINT-63354 I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HYPK

    Search CenterWatch for drugs/clinical trials and news about HYPK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HYPK gene (2 alternative transcripts): 
    NM_001199885.1  NM_016400.3  

    Unigene Cluster for HYPK:

    Huntingtin interacting protein K
    Hs.730672  [show with all ESTs]
    Unigene Representative Sequence: NR_037673
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406925 ENST00000498605 ENST00000442995 ENST00000458412(uc001ztg.1)
    ENST00000497142
    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HYPK
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HYPK

    Additional mRNA sequence: 

    AF049613.1 AF161485.1 AK022435.1 BC019262.1 NR_037673.1 

    11 DOTS entries:

    DT.100775382  DT.101978832  DT.95253061  DT.91901618  DT.95130407  DT.95130380  DT.112871  DT.100040240 
    DT.75116920  DT.91751889  DT.121314723 

    24/1824 AceView cDNA sequences (see all 1824):

    CB157827 BG117313 CB139072 BQ478474 CB137317 BQ671455 BM710562 AI189868 
    BU734389 AI199192 CR622391 BM747974 BQ772100 BI521391 CF130736 AI313215 
    BM765216 AI699708 BX484367 AI192559 BF032633 BX646948 AI204501 AA704411 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HYPK expression in normal human tissues (normalized intensities)      HYPK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HYPK Expression
    About this image


    HYPK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer

    See HYPK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HYPK

    SOURCE GeneReport for Unigene cluster: Hs.730672
        SABiosciences Custom PCR Arrays for HYPK
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HYPK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HYPK gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hypk1 , 5 RIKEN cDNA 2310003F16 gene5
    huntingtin interacting protein K1
    87.34(n)1
    99.22(a)1
      2 (60.39 cM)5
    676931  NM_026318.31  NP_080594.21 
     1214532905 
    chicken
    (Gallus gallus)
    Aves SERF21 small EDRK-rich factor 2 82.09(n)
    92.56(a)
      770307  XM_001233639.2  XP_001233640.2 
    lizard
    (Anolis carolinensis)
    Reptilia C15ORF636
    Uncharacterized protein
    86(a)
    1 ↔ 1
    GL343759.1(184952-188648)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.64062 Xenopus laevis transcribed sequence with strong similarity more 80.83(n)    CB197613.2 
    zebrafish
    (Danio rerio)
    Actinopterygii hypk1 huntingtin interacting protein K 73(n)
    86.78(a)
      100151755  NM_001127470.1  NP_001120942.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG99221 CG9922 50.91(n)
    49.09(a)
      41708  NM_142072.2  NP_650329.1 


    ENSEMBL Gene Tree for HYPK (if available)
    TreeFam Gene Tree for HYPK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HYPK gene

    HYPK for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for HYPK
    PGOHUM00000250976 PGOHUM00000242001


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1 SNPs in HYPK are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0303354
    ----see VAR_0303352 S P mis40--------

    HapMap Linkage Disequilibrium report for HYPK (44088340 - 44095241 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HYPK: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HYPK
    DNA2.0 Custom Variant and Variant Library Synthesis for HYPK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612784    OMIM disorders: --

    2 diseases for HYPK:    About MalaCards
    influenza    neuronitis


    HYPK for disorders           About GeneDecksing


    Export disorders for HYPK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HYPK gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with HYPK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The chaperone-like protein HYPK acts together with Na tA in cotranslational N-terminal acetylation and prevention of Huntingtin aggre gation. (PubMed id 20154145)1, 2, 3, 9 Arnesen T....Anderson D. (2010)
    2. Huntingtin interacts with a family of WW domain proteins. (PubMed id 9700202)1, 2, 3 Faber P.W....MacDonald M.E. (1998)
    3. HYPK, a Huntingtin interacting protein, reduces aggregates and apoptosis induced by N-terminal Huntingtin with 40 glutamines in Neuro2a cells and exhibits chaperone-like activity. (PubMed id 17947297)1, 2 Raychaudhuri S....Bhattacharyya N.P. (2008)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Identification of HYPK-interacting proteins reveals in volvement of HYPK in regulating cell growth, cell cycle, unfolded protein respon se and cell death. (PubMed id 23272104)1 Choudhury K.R....Bhattacharyya N.P. (2012)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25764 HGNC: 18418 AceView: SERF2andHYPK Ensembl:ENSG00000242028 euGenes: HUgn25764
    ECgene: HYPK H-InvDB: HYPK

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HYPK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HYPK gene:
    Search GeneIP for patents involving HYPK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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