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HYPK Gene

protein-coding   GIFtS: 36
GCID: GC15P044095

Huntingtin Interacting Protein K

(Previous name: chromosome 15 open reading frame 63)
(Previous symbol: C15orf63)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Huntingtin Interacting Protein K1 2     Huntingtin-Interacting Protein K2
C15orf631 2 3     EC 2.1.1.438
Huntingtin Yeast Partner K1 2 3     EC 2.7.7.68
Chromosome 15 Open Reading Frame 631     

External Ids:    HGNC: 184181   Entrez Gene: 257642   Ensembl: ENSG000002420287   OMIM: 6127845   UniProtKB: Q9NX553   

Export aliases for HYPK gene to outside databases

Previous GC identifers: GC15P039459 GC15P036988 GC15P041671 GC15P041808 GC15P041879 GC15P044070 GC15P044092


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HYPK Gene:
HYPK (huntingtin interacting protein K) is a protein-coding gene.

UniProtKB/Swiss-Prot: HYPK_HUMAN, Q9NX55
Function: Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT
polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10-NAA15 complex-mediated N-terminal
acetylation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the HYPK gene promoter:
         AREB6   PPAR-alpha   NF-1   AML1a   Msx-1   Tal-1beta   ITF-2   Pax-4a   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHYPK promoter sequence
   Search Chromatin IP Primers for HYPK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HYPK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.3   Ensembl cytogenetic band:  15q15.3   HGNC cytogenetic band: 15q14

HYPK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HYPK gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P044095:  view genomic region     (about GC identifiers)

Start:
44,088,340 bp from pter      End:
44,095,241 bp from pter
Size:
6,902 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HYPK_HUMAN, Q9NX55 (See protein sequence)
Recommended Name: Huntingtin-interacting protein K  
Size: 129 amino acids; 14665 Da
Subunit: Interacts with HTT (via N-terminus). Associates with the NAA10-NAA15 complex and with the ribosome; the
NAA10-NAA15 complex is required for HYPK stability and for reducing polyQ aggregation of HTT. Interacts with
NAA15
Sequence caution: Sequence=AAF29100.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA91165.1; Type=Miscellaneous discrepancy; Note=Readthrough transcript SERF2-HYPK/C15orf63;
Secondary accessions: C9JKJ0 O75408 Q8WUW8 Q9P024
Alternative splicing: 2 isoforms:  Q9NX55-2   Q9NX55-3   

Explore the universe of human proteins at neXtProt for HYPK: NX_Q9NX55

Explore proteomics data for HYPK at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for HYPK (Q9NX55)
     VSVAGSR  QEREKEL 


    See HYPK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186814.1  NP_057484.3  

    ENSEMBL proteins: 
     ENSP00000384474   ENSP00000401155   ENSP00000394060  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9NX55


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HYPK_HUMAN, Q9NX55
    Function: Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT
    polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10-NAA15 complex-mediated N-terminal
    acetylation

         Enzyme Numbers (IUBMB): EC 2.1.1.432 EC 2.7.7.62

    Phenotypes:
         2 GenomeRNAi human phenotypes for HYPK:

     Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HYPK

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HYPK_HUMAN, Q9NX55: Nucleus. Cytoplasm

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with HYPK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HYPK
    Interactions:

        Search GeneGlobe Interaction Network for HYPK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for HYPK (Q9NX552, 3 ENSP000003844744) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NELFCDQ8IXH72, 3, ENSP000003423004MINT-64862 I2D: score=1 STRING: ENSP00000342300
    RBPMSQ930622, 3, ENSP000003401764MINT-67321 I2D: score=1 STRING: ENSP00000340176
    RHOXF2Q9BQY42, 3, ENSP000003604414MINT-66750 I2D: score=1 STRING: ENSP00000360441
    CHD3Q128732, 3MINT-65656 I2D: score=1 
    GCP027742, 3MINT-63354 I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HYPK



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HYPK gene (2 alternative transcripts): 
    NM_001199885.1  NM_016400.3  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406925 ENST00000498605 ENST00000442995 ENST00000458412(uc001ztg.1)
    ENST00000497142
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat HYPK
      QuantiFast Probe-based Assays in human, mouse, rat HYPK

    Selected AceView cDNA sequences (see all 1824):

    BE727076 BM835157 BM744603 AW029437 BI819150 AA973243 BM855714 AI337987 
    AA777987 BQ061006 AI266574 AI565129 BM768441 AI042328 BG942585 AI204501 
    BX484367 AW007323 BC015491 BU196572 AI337557 BQ061048 AI189868 AI983787 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HYPK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HYPK Expression
    About this image


    HYPK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
    HYPK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HYPK Protein Expression
        Custom PCR Arrays for HYPK
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HYPK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HYPK gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hypk1 , 5 RIKEN cDNA 2310003F16 gene5
    huntingtin interacting protein K1
    87.34(n)1
    99.22(a)1
      2 (60.39 cM)5
    676931  NM_026318.31  NP_080594.21 
     1214532905 
    chicken
    (Gallus gallus)
    Aves HYPK1 huntingtin interacting protein K 82.09(n)
    92.5(a)
      770307  NM_001277654.1  NP_001264583.1 
    lizard
    (Anolis carolinensis)
    Reptilia HYPK6
    huntingtin interacting protein K
    86(a)
    1 ↔ 1
    GL343759.1(184952-188648)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.64062 Xenopus laevis transcribed sequence with strong similarity more 80.83(n)    CB197613.2 
    zebrafish
    (Danio rerio)
    Actinopterygii hypk1 huntingtin interacting protein K 73(n)
    86.78(a)
      100151755  NM_001127470.1  NP_001120942.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG99221 CG9922 50.91(n)
    49.09(a)
      41708  NM_001275627.1  NP_001262556.1 


    ENSEMBL Gene Tree for HYPK (if available)
    TreeFam Gene Tree for HYPK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HYPK gene

    Find genes that share paralogs with HYPK           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for HYPK
    PGOHUM00000250976 PGOHUM00000242001


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for HYPK    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs127021,2,4
    ----see VAR_0303352 mis40--------

    HapMap Linkage Disequilibrium report for HYPK (44088340 - 44095241 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HYPK: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HYPK
    DNA2.0 Custom Variant and Variant Library Synthesis for HYPK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612784    OMIM disorders: --


    Find genes that share disorders with HYPK           About GenesLikeMe


    Export disorders for HYPK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HYPK gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with HYPK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation. (PubMed id 20154145)1, 2, 3, 9 Arnesen T.... Anderson D. (Mol. Cell. Biol. 2010)
    2. Huntingtin interacts with a family of WW domain proteins. (PubMed id 9700202)1, 2, 3 Faber P.W....MacDonald M.E. (Hum. Mol. Genet. 1998)
    3. HYPK, a Huntingtin interacting protein, reduces aggregates and apoptosis induced by N-terminal Huntingtin with 40 glutamines in Neuro2a cells and exhibits chaperone-like activity. (PubMed id 17947297)1, 2 Raychaudhuri S.... Bhattacharyya N.P. (Hum. Mol. Genet. 2008)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    6. Heat shock transcription factor HSF1 regulates the expression of the Huntingtin-interacting protein HYPK. (PubMed id 24361604)1 Sakurai H....Kawahara E. (Biochim. Biophys. Acta 2014)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Identification of HYPK-interacting proteins reveals involvement of HYPK in regulating cell growth, cell cycle, unfolded protein response and cell death. (PubMed id 23272104)1 Choudhury K.R....Bhattacharyya N.P. (PLoS ONE 2012)
    9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25764 HGNC: 18418 AceView: SERF2andHYPK Ensembl:ENSG00000242028 euGenes: HUgn25764
    ECgene: HYPK H-InvDB: HYPK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HYPK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HYPK gene:
    Search GeneIP for patents involving HYPK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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