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Aliases for HYPK Gene

Aliases for HYPK Gene

  • Huntingtin Interacting Protein K 2 3 5
  • Huntingtin Yeast Partner K 2 3 4
  • C15orf63 3 4
  • Chromosome 15 Open Reading Frame 63 2
  • EC 63
  • EC 63
  • HSPC136 3

External Ids for HYPK Gene

Previous HGNC Symbols for HYPK Gene

  • C15orf63

Previous GeneCards Identifiers for HYPK Gene

  • GC15P039459
  • GC15P036988
  • GC15P041671
  • GC15P041808
  • GC15P041879
  • GC15P044070
  • GC15P044092
  • GC15P044095

Summaries for HYPK Gene

GeneCards Summary for HYPK Gene

HYPK (Huntingtin Interacting Protein K) is a Protein Coding gene.

UniProtKB/Swiss-Prot for HYPK Gene

  • Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10-NAA15 complex-mediated N-terminal acetylation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HYPK Gene

Genomics for HYPK Gene

Regulatory Elements for HYPK Gene

Enhancers for HYPK Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HYPK on UCSC Golden Path with GeneCards custom track

Genomic Location for HYPK Gene

43,796,142 bp from pter
43,803,043 bp from pter
6,902 bases
Plus strand

Genomic View for HYPK Gene

Genes around HYPK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HYPK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HYPK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HYPK Gene

Proteins for HYPK Gene

  • Protein details for HYPK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Huntingtin-interacting protein K
    Protein Accession:
    Secondary Accessions:
    • C9JKJ0
    • O75408
    • Q8WUW8
    • Q9P024

    Protein attributes for HYPK Gene

    129 amino acids
    Molecular mass:
    14665 Da
    Quaternary structure:
    • Interacts with HTT (via N-terminus). Associates with the NAA10-NAA15 complex and with the ribosome; the NAA10-NAA15 complex is required for HYPK stability and for reducing polyQ aggregation of HTT. Interacts with NAA15.
    • Sequence=AAF29100.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91165.1; Type=Miscellaneous discrepancy; Note=Readthrough transcript SERF2-HYPK/C15orf63.; Evidence={ECO:0000305};

    Alternative splice isoforms for HYPK Gene


neXtProt entry for HYPK Gene

Proteomics data for HYPK Gene at MOPED

Selected DME Specific Peptides for HYPK Gene

Post-translational modifications for HYPK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HYPK Gene

Domains & Families for HYPK Gene

Protein Domains for HYPK Gene


Suggested Antigen Peptide Sequences for HYPK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HYPK: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HYPK Gene

Function for HYPK Gene

Molecular function for HYPK Gene

UniProtKB/Swiss-Prot Function:
Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10-NAA15 complex-mediated N-terminal acetylation.

Enzyme Numbers (IUBMB) for HYPK Gene

genes like me logo Genes that share phenotypes with HYPK: view

Animal Model Products

CRISPR Products

miRNA for HYPK Gene

miRTarBase miRNAs that target HYPK

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HYPK Gene

Localization for HYPK Gene

Subcellular locations from UniProtKB/Swiss-Prot for HYPK Gene

Nucleus. Cytoplasm.

Subcellular locations from

Jensen Localization Image for HYPK Gene COMPARTMENTS Subcellular localization image for HYPK gene
Compartment Confidence
nucleus 5
cytoskeleton 4

Gene Ontology (GO) - Cellular Components for HYPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HYPK: view

Pathways & Interactions for HYPK Gene

SuperPathways for HYPK Gene

No Data Available

Gene Ontology (GO) - Biological Process for HYPK Gene


No data available for Pathways by source and SIGNOR curated interactions for HYPK Gene

Drugs & Compounds for HYPK Gene

No Compound Related Data Available

Transcripts for HYPK Gene

Unigene Clusters for HYPK Gene

Huntingtin interacting protein K:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HYPK Gene

No ASD Table

Relevant External Links for HYPK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HYPK Gene

mRNA expression in normal human tissues for HYPK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HYPK Gene

This gene is overexpressed in Blymphocyte (15.1), Peripheral blood mononuclear cells (13.2), and CD4 Tcells (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HYPK Gene

SOURCE GeneReport for Unigene cluster for HYPK Gene Hs.730672

genes like me logo Genes that share expression patterns with HYPK: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HYPK Gene

Orthologs for HYPK Gene

This gene was present in the common ancestor of animals.

Orthologs for HYPK Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C21H15orf63 35
  • 91.18 (n)
  • 100 (a)
C21H15orf63 36
  • 94 (a)
(Canis familiaris)
Mammalia HYPK 35
  • 92.29 (n)
  • 100 (a)
(Mus musculus)
Mammalia Hypk 35
  • 87.34 (n)
  • 99.22 (a)
Hypk 16
Hypk 36
  • 99 (a)
(Pan troglodytes)
Mammalia LOC745332 35
  • 93.8 (n)
  • 89.06 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Hypk 35
  • 88.15 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 95 (a)
-- 36
  • 93 (a)
(Gallus gallus)
Aves HYPK 35
  • 82.09 (n)
  • 92.5 (a)
  • 83 (a)
(Anolis carolinensis)
Reptilia HYPK 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hypk 35
  • 78.79 (n)
  • 90.91 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6406 35
(Danio rerio)
Actinopterygii hypk 35
  • 73 (n)
  • 86.78 (a)
hypk 36
  • 87 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13793 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004606 35
  • 55.56 (n)
  • 56.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9922 35
  • 50.91 (n)
  • 49.09 (a)
CG9922 36
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2928 36
  • 55 (a)
Species with no ortholog for HYPK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HYPK Gene

Gene Tree for HYPK (if available)
Gene Tree for HYPK (if available)

Paralogs for HYPK Gene Pseudogenes for HYPK Gene

genes like me logo Genes that share paralogs with HYPK: view

No data available for Paralogs for HYPK Gene

Variants for HYPK Gene

Sequence variations from dbSNP and Humsavar for HYPK Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_030335 -

Variation tolerance for HYPK Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for HYPK Gene

Disorders for HYPK Gene

Relevant External Links for HYPK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HYPK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HYPK Gene

Publications for HYPK Gene

  1. The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation. (PMID: 20154145) Arnesen T. … Anderson D. (Mol. Cell. Biol. 2010) 2 3 4 23 67
  2. Huntingtin interacts with a family of WW domain proteins. (PMID: 9700202) Faber P.W. … MacDonald M.E. (Hum. Mol. Genet. 1998) 2 3
  3. Chaperone protein HYPK interacts with the first 17 amino acid region of Huntingtin and modulates mutant HTT-mediated aggregation and cytotoxicity. (PMID: 25446099) Choudhury K.R. … Bhattacharyya N.P. (Biochem. Biophys. Res. Commun. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for HYPK Gene

Sources for HYPK Gene