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Aliases for HYPK Gene

Aliases for HYPK Gene

  • Huntingtin Interacting Protein K 2 3 5
  • Huntingtin Yeast Partner K 2 3 4
  • C15orf63 3 4
  • Chromosome 15 Open Reading Frame 63 2
  • Huntingtin-Interacting Protein K 3
  • EC 2.1.1.43 56
  • EC 2.7.7.6 56
  • HSPC136 3

External Ids for HYPK Gene

Previous HGNC Symbols for HYPK Gene

  • C15orf63

Previous GeneCards Identifiers for HYPK Gene

  • GC15P039459
  • GC15P036988
  • GC15P041671
  • GC15P041808
  • GC15P041879
  • GC15P044070
  • GC15P044092
  • GC15P044095

Summaries for HYPK Gene

GeneCards Summary for HYPK Gene

HYPK (Huntingtin Interacting Protein K) is a Protein Coding gene.

UniProtKB/Swiss-Prot for HYPK Gene

  • Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10-NAA15 complex-mediated N-terminal acetylation.

Additional gene information for HYPK Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HYPK Gene

Genomics for HYPK Gene

GeneHancer (GH) Regulatory Elements for HYPK Gene

Promoters and enhancers for HYPK Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I043791 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 550.8 +0.4 353 10.5 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 SP3 NFYC MEF2D GC15M043788 GC15P043795 HYPK PIR54305 SERINC4 SERF2 SPG11 CTDSPL2 ENSG00000259563 RPS3AP47
GH15I043132 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.6 -662.4 -662353 2.2 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B TMEM62 HYPK ADAL CATSPER2 GANC SPCS2P1 FDPSP10 EPB42
GH15I043769 Enhancer 0.6 ENCODE 12 -26.3 -26344 0.2 CTCF FOXA2 TEAD1 FOXA3 TEAD4 TRIM22 ZNF384 RAD21 RFX5 MAFF MIR1282 HYPK SERF2 CATSPER2P1 PDIA3
GH15I043749 Enhancer 0.6 ENCODE 11.8 -45.9 -45937 1.7 ZNF121 PKNOX1 ZNF384 ATF7 PRDM10 ELF1 PRDM1 ZNF18 STRC SERF2 MIR1282 HYPK CATSPER2P1 PDIA3
GH15I043434 Enhancer 0.5 ENCODE 10.2 -361.5 -361494 0.4 ZNF639 ZNF766 ZBTB11 GABPA ZSCAN29 TUBGCP4 MIR1282 HYPK SERF2 PIR48108 PIR42778 TP53BP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HYPK on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HYPK gene promoter:

Genomic Locations for HYPK Gene

Genomic Locations for HYPK Gene
chr15:43,796,142-43,803,043
(GRCh38/hg38)
Size:
6,902 bases
Orientation:
Plus strand
chr15:44,088,340-44,095,241
(GRCh37/hg19)

Genomic View for HYPK Gene

Genes around HYPK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HYPK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HYPK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HYPK Gene

Proteins for HYPK Gene

  • Protein details for HYPK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX55-HYPK_HUMAN
    Recommended name:
    Huntingtin-interacting protein K
    Protein Accession:
    Q9NX55
    Secondary Accessions:
    • C9JKJ0
    • O75408
    • Q8WUW8
    • Q9P024

    Protein attributes for HYPK Gene

    Size:
    129 amino acids
    Molecular mass:
    14665 Da
    Quaternary structure:
    • Interacts with HTT (via N-terminus). Associates with the NAA10-NAA15 complex and with the ribosome; the NAA10-NAA15 complex is required for HYPK stability and for reducing polyQ aggregation of HTT. Interacts with NAA15.
    SequenceCaution:
    • Sequence=AAF29100.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91165.1; Type=Miscellaneous discrepancy; Note=Readthrough transcript SERF2-HYPK/C15orf63.; Evidence={ECO:0000305};

    Alternative splice isoforms for HYPK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HYPK Gene

Selected DME Specific Peptides for HYPK Gene

Q9NX55:
  • QEREKEL
  • VSVAGSR

Post-translational modifications for HYPK Gene

No Post-translational modifications

Other Protein References for HYPK Gene

Domains & Families for HYPK Gene

Gene Families for HYPK Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HYPK Gene

ProtoNet:

Suggested Antigen Peptide Sequences for HYPK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HYPK: view

No data available for UniProtKB/Swiss-Prot for HYPK Gene

Function for HYPK Gene

Molecular function for HYPK Gene

UniProtKB/Swiss-Prot Function:
Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Required for optimal NAA10-NAA15 complex-mediated N-terminal acetylation.

Enzyme Numbers (IUBMB) for HYPK Gene

Gene Ontology (GO) - Molecular Function for HYPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0047485 protein N-terminus binding IPI 17947297
genes like me logo Genes that share ontologies with HYPK: view
genes like me logo Genes that share phenotypes with HYPK: view

miRNA for HYPK Gene

miRTarBase miRNAs that target HYPK

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HYPK Gene

Localization for HYPK Gene

Subcellular locations from UniProtKB/Swiss-Prot for HYPK Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HYPK gene
Compartment Confidence
nucleus 5
cytoskeleton 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HYPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17947297
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 17947297
GO:0015630 microtubule cytoskeleton IDA --
GO:0043234 protein complex IDA 17947297
genes like me logo Genes that share ontologies with HYPK: view

Pathways & Interactions for HYPK Gene

No Data Available

Gene Ontology (GO) - Biological Process for HYPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043066 negative regulation of apoptotic process IDA 17947297
GO:0050821 protein stabilization IDA 17947297
genes like me logo Genes that share ontologies with HYPK: view

No data available for Pathways by source and SIGNOR curated interactions for HYPK Gene

Drugs & Compounds for HYPK Gene

No Compound Related Data Available

Transcripts for HYPK Gene

Unigene Clusters for HYPK Gene

Huntingtin interacting protein K:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HYPK Gene

No ASD Table

Relevant External Links for HYPK Gene

GeneLoc Exon Structure for
HYPK
ECgene alternative splicing isoforms for
HYPK

Expression for HYPK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HYPK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HYPK Gene

This gene is overexpressed in Blymphocyte (15.1), Peripheral blood mononuclear cells (13.2), and CD4 Tcells (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HYPK Gene



NURSA nuclear receptor signaling pathways regulating expression of HYPK Gene:

HYPK

SOURCE GeneReport for Unigene cluster for HYPK Gene:

Hs.730672

Evidence on tissue expression from TISSUES for HYPK Gene

  • Liver(4.4)
  • Blood(4.1)
  • Nervous system(2.2)
  • Heart(2)
genes like me logo Genes that share expression patterns with HYPK: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HYPK Gene

Orthologs for HYPK Gene

This gene was present in the common ancestor of animals.

Orthologs for HYPK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HYPK 34
  • 100 (a)
OneToOne
LOC745332 33
  • 93.8 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 95 (a)
OneToMany
-- 34
  • 93 (a)
OneToMany
dog
(Canis familiaris)
Mammalia HYPK 33
  • 92.29 (n)
cow
(Bos Taurus)
Mammalia C21H15orf63 33 34
  • 91.18 (n)
rat
(Rattus norvegicus)
Mammalia Hypk 33
  • 88.15 (n)
mouse
(Mus musculus)
Mammalia Hypk 33 16 34
  • 87.34 (n)
chicken
(Gallus gallus)
Aves HYPK 33 34
  • 82.09 (n)
lizard
(Anolis carolinensis)
Reptilia HYPK 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hypk 33
  • 78.79 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6406 33
zebrafish
(Danio rerio)
Actinopterygii hypk 33 34
  • 73 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13793 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004606 33
  • 55.56 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9922 33 34
  • 50.91 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2928 34
  • 55 (a)
OneToOne
Species where no ortholog for HYPK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HYPK Gene

ENSEMBL:
Gene Tree for HYPK (if available)
TreeFam:
Gene Tree for HYPK (if available)

Paralogs for HYPK Gene

Pseudogenes.org Pseudogenes for HYPK Gene

genes like me logo Genes that share paralogs with HYPK: view

No data available for Paralogs for HYPK Gene

Variants for HYPK Gene

Sequence variations from dbSNP and Humsavar for HYPK Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000068099 -- 43,802,476(+) C/T 3_prime_UTR_variant
rs1000288190 -- 43,802,217(+) G/A/C 3_prime_UTR_variant
rs1005404826 -- 43,802,751(+) A/G downstream_transcript_variant
rs1005493589 -- 43,802,555(+) G/A 3_prime_UTR_variant
rs1005966945 -- 43,798,848(+) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HYPK Gene

Variant ID Type Subtype PubMed ID
esv2760028 CNV gain+loss 17122850
nsv1036318 CNV gain 25217958
nsv1050263 CNV loss 25217958

Variation tolerance for HYPK Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HYPK Gene

Human Gene Mutation Database (HGMD)
HYPK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HYPK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HYPK Gene

Disorders for HYPK Gene

Additional Disease Information for HYPK

No disorders were found for HYPK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HYPK Gene

Publications for HYPK Gene

  1. The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation. (PMID: 20154145) Arnesen T … Anderson D (Molecular and cellular biology 2010) 2 3 4 22 58
  2. Huntingtin interacts with a family of WW domain proteins. (PMID: 9700202) Faber PW … MacDonald ME (Human molecular genetics 1998) 2 3 4 58
  3. HYPK, a Huntingtin interacting protein, reduces aggregates and apoptosis induced by N-terminal Huntingtin with 40 glutamines in Neuro2a cells and exhibits chaperone-like activity. (PMID: 17947297) Raychaudhuri S … Bhattacharyya NP (Human molecular genetics 2008) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4 58

Products for HYPK Gene

Sources for HYPK Gene

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