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Aliases for HYOU1 Gene

Aliases for HYOU1 Gene

  • Hypoxia Up-Regulated 1 2 3
  • 170 KDa Glucose-Regulated Protein 3 4
  • 150 KDa Oxygen-Regulated Protein 3 4
  • GRP-170 3 4
  • ORP-150 3 4
  • Grp170 3 4
  • ORP150 3 4
  • Oxygen Regulated Protein (150kD) 3
  • Hypoxia Up-Regulated Protein 1 3
  • Glucose-Regulated Protein 170 2
  • HSP12A 3

External Ids for HYOU1 Gene

Summaries for HYOU1 Gene

Entrez Gene Summary for HYOU1 Gene

  • The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for HYOU1 Gene

HYOU1 (Hypoxia Up-Regulated 1) is a Protein Coding gene. Diseases associated with HYOU1 include hypoxia and myocardial infarction. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Unfolded Protein Response. An important paralog of this gene is HSPH1.

UniProtKB/Swiss-Prot for HYOU1 Gene

  • Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.

Gene Wiki entry for HYOU1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HYOU1 Gene

Genomics for HYOU1 Gene

Genomic Location for HYOU1 Gene

Start:
119,044,185 bp from pter
End:
119,057,240 bp from pter
Size:
13,056 bases
Orientation:
Minus strand

Genomic View for HYOU1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HYOU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HYOU1 Gene

Regulatory Elements for HYOU1 Gene

Transcription factor binding sites by QIAGEN in the HYOU1 gene promoter:

Proteins for HYOU1 Gene

  • Protein details for HYOU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4L1-HYOU1_HUMAN
    Recommended name:
    Hypoxia up-regulated protein 1
    Protein Accession:
    Q9Y4L1
    Secondary Accessions:
    • A8C1Z0
    • B7Z909
    • Q2I204
    • Q53H25

    Protein attributes for HYOU1 Gene

    Size:
    999 amino acids
    Molecular mass:
    111335 Da
    Quaternary structure:
    • Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX

    Alternative splice isoforms for HYOU1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HYOU1 Gene

Proteomics data for HYOU1 Gene at MOPED

Post-translational modifications for HYOU1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys398
  • Glycosylation at Asn155, Asn222, Asn515, Thr580, Thr589, Thr590, Asn596, Asn830, Asn862, Asn869, Asn922, and Asn931

No data available for DME Specific Peptides for HYOU1 Gene

Domains for HYOU1 Gene

Gene Families for HYOU1 Gene

HGNC:
  • HSP70 :Heat shock proteins / HSP70

Protein Domains for HYOU1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y4L1

UniProtKB/Swiss-Prot:

HYOU1_HUMAN
Family:
  • Belongs to the heat shock protein 70 family.:
    • Q9Y4L1
genes like me logo Genes that share domains with HYOU1: view

Function for HYOU1 Gene

Molecular function for HYOU1 Gene

UniProtKB/Swiss-Prot Function: Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.
UniProtKB/Swiss-Prot Induction: By hypoxia and also by 2-deoxyglucose or tunicamycin

Gene Ontology (GO) - Molecular Function for HYOU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0051087 chaperone binding ISS 10837345
genes like me logo Genes that share ontologies with HYOU1: view
genes like me logo Genes that share phenotypes with HYOU1: view

Animal Models for HYOU1 Gene

MGI Knock Outs for HYOU1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HYOU1 Gene

Localization for HYOU1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HYOU1 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HYOU1 Gene COMPARTMENTS Subcellular localization image for HYOU1 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for HYOU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005783 endoplasmic reticulum NAS 9020069
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005790 smooth endoplasmic reticulum ISS --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with HYOU1: view

Pathways for HYOU1 Gene

genes like me logo Genes that share pathways with HYOU1: view

Interacting Proteins for HYOU1 Gene

Gene Ontology (GO) - Biological Process for HYOU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis --
GO:0002931 response to ischemia ISS --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006950 response to stress --
GO:0006987 activation of signaling protein activity involved in unfolded protein response --
genes like me logo Genes that share ontologies with HYOU1: view

Compounds for HYOU1 Gene

(14) Novoseek inferred chemical compound relationships for HYOU1 Gene

Compound -log(P) Hits PubMed IDs
hemocyanin 71.6 5
oxygen 59.2 50
tunicamycin 47.2 1
vegf 29.6 15
2-deoxyglucose 25.5 2
genes like me logo Genes that share compounds with HYOU1: view

Transcripts for HYOU1 Gene

Unigene Clusters for HYOU1 Gene

Hypoxia up-regulated 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HYOU1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - -
SP2: - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: -
SP7: - -
SP8: - - -
SP9:
SP10:

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for HYOU1 Gene

GeneLoc Exon Structure for
HYOU1
ECgene alternative splicing isoforms for
HYOU1

Expression for HYOU1 Gene

mRNA expression in normal human tissues for HYOU1 Gene

mRNA differential expression in normal tissues according to GTEx for HYOU1 Gene

This gene is overexpressed in Liver (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for HYOU1 Gene

SOURCE GeneReport for Unigene cluster for HYOU1 Gene Hs.277704

mRNA Expression by UniProt/SwissProt for HYOU1 Gene

Q9Y4L1-HYOU1_HUMAN
Tissue specificity: Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers
genes like me logo Genes that share expressions with HYOU1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for HYOU1 Gene

Orthologs for HYOU1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HYOU1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HYOU1 35
  • 99.14 (n)
  • 98.7 (a)
HYOU1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HYOU1 35
  • 89.31 (n)
  • 91.88 (a)
HYOU1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HYOU1 35
  • 89.46 (n)
  • 93.17 (a)
HYOU1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hyou1 35
  • 87.55 (n)
  • 92.09 (a)
Hyou1 16
Hyou1 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HYOU1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 26 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Hyou1 35
  • 88.21 (n)
  • 92.38 (a)
chicken
(Gallus gallus)
Aves HYOU1 35
  • 69.35 (n)
  • 72.07 (a)
HYOU1 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HYOU1 36
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398531 35
tropical clawed frog
(Silurana tropicalis)
Amphibia hyou1 35
  • 67.8 (n)
  • 70.43 (a)
Str.3875 35
zebrafish
(Danio rerio)
Actinopterygii Dr.17462 35
hyou1 35
  • 67.31 (n)
  • 69.54 (a)
hyou1 36
  • 66 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001827 35
  • 54.22 (n)
  • 46.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2918 35
  • 54.34 (n)
  • 47.02 (a)
CG2918 36
  • 44 (a)
OneToOne
EG:25E8.1 37
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea T14G8.3 35
  • 49.73 (n)
  • 39.09 (a)
T14G8.3 36
  • 36 (a)
OneToMany
T24H7.2 36
  • 34 (a)
OneToMany
T24H7.2 37
  • 34 (a)
T14G8.3 37
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSE1 36
  • 27 (a)
ManyToMany
SSE2 36
  • 25 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G16660 35
  • 47.8 (n)
  • 38.39 (a)
rice
(Oryza sativa)
Liliopsida Os02g0710900 35
  • 47.36 (n)
  • 35.39 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4458 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9387 36
  • 43 (a)
OneToOne
Species with no ortholog for HYOU1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HYOU1 Gene

ENSEMBL:
Gene Tree for HYOU1 (if available)
TreeFam:
Gene Tree for HYOU1 (if available)

Paralogs for HYOU1 Gene

Paralogs for HYOU1 Gene

Pseudogenes.org Pseudogenes for HYOU1 Gene

genes like me logo Genes that share paralogs with HYOU1: view

Variants for HYOU1 Gene

Sequence variations from dbSNP and Humsavar for HYOU1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs13929 -- 119,045,044(+) AGCTG(C/G)ATGGG utr-variant-3-prime
rs13979 -- 119,044,480(-) GCCTA(G/T)GGAGC utr-variant-3-prime
rs470324 -- 119,053,500(-) CCCTG(C/T)GCCTG intron-variant
rs470679 -- 119,056,008(-) GGGAA(G/T)TGAGC intron-variant
rs471028 -- 119,057,682(+) GCTGT(C/G)CCTCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HYOU1 Gene

Variant ID Type Subtype PubMed ID
nsv898416 CNV Loss 21882294
nsv819696 CNV Loss 19587683

Relevant External Links for HYOU1 Gene

HapMap Linkage Disequilibrium report
HYOU1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HYOU1 Gene

Disorders for HYOU1 Gene

(11) Novoseek inferred disease relationships for HYOU1 Gene

Disease -log(P) Hits PubMed IDs
brain ischemia 31.9 2
shock 29.6 7
invasive cancer 27.2 2
ischemia 14.7 4
atherosclerotic plaque 10.7 2

Relevant External Links for HYOU1

Genetic Association Database (GAD)
HYOU1
Human Genome Epidemiology (HuGE) Navigator
HYOU1
genes like me logo Genes that share disorders with HYOU1: view

No data available for UniProtKB/Swiss-Prot for HYOU1 Gene

Publications for HYOU1 Gene

  1. Cloning and expression of cDNA encoding the human 150 kDa oxygen- regulated protein, ORP150. (PMID: 9020069) Ikeda J. … Yanagi H. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 23
  2. 150-kDa oxygen-regulated protein (ORP150) suppresses hypoxia-induced apoptotic cell death. (PMID: 10037731) Ozawa K. … Tohyama M. (J. Biol. Chem. 1999) 2 3 4 23
  3. Production of three distinct mRNAs of 150 kDa oxygen-regulated protein (ORP150) by alternative promoters: preferential induction of one species under stress conditions. (PMID: 10965054) Kaneda S. … Yanagi H. (J. Biochem. 2000) 3 4 23
  4. Molecular cloning, sequence, function and structural basis of human heart 150 kDa oxygen-regulated protein, an ER chaperone. (PMID: 17131193) Takeuchi S. (Protein J. 2006) 3 4 23
  5. ORP150/HSP12A protects renal tubular epithelium from ischemia-induced cell death. (PMID: 15240565) Bando Y. … Ogawa S. (FASEB J. 2004) 3 23

Products for HYOU1 Gene

Sources for HYOU1 Gene

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