HYOU1 Gene
protein-coding GIFtS: 61
GCID: GC11M118914
|
|
hypoxia up-regulated 1
| |
Aliases
for HYOU1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Hypoxia Up-Regulated 11 2 | | GRP-1702 3 | | ORP1501 2 3 | | ORP-1502 3 | | Grp1701 2 | | Glucose-Regulated Protein 1702 | | HSP12A1 2 | | Hypoxia Up-Regulated Protein 12 | | 150 KDa Oxygen-Regulated Protein2 3 | | Oxygen Regulated Protein (150kD)2 | | 170 KDa Glucose-Regulated Protein2 3 | | GRP1703 |
Export aliases for HYOU1 gene to outside databasesPrevious GC identifers: GC11P135580 GC11M120426 GC11M118948 GC11M118452 GC11M118420 GC11M114854 |
Summaries
for HYOU1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HYOU1:
The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcriptionstart sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in theaccumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by thisgene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the proteinis associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role inhypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breasttumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiationsite, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which isonly 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in thecytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria byan amino-terminal targeting signal. (provided by RefSeq, Oct 2008)
UniProtKB/Swiss-Prot: HYOU1_HUMAN, Q9Y4L1Function: Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role asa molecular chaperone and participate in protein folding
Gene Wiki entry for HYOU1
|
Genomic Views
for HYOU1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HYOU1 gene promoter:
p53 MyoD
Other transcription factors
Search SABiosciences Chromatin IP Primers for HYOU1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HYOU1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q23.1-q23.3 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23.1-q23.3HYOU1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M118914: view genomic region
(about GC identifiers)
Start:
|
118,914,896 bp from pter |
End:
|
118,927,925 bp from pter |
Size:
|
13,030 bases |
Orientation:
|
minus strand |
|
Proteins
for HYOU1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HYOU1_HUMAN, Q9Y4L1 (See
protein sequence)Recommended Name: Hypoxia up-regulated protein 1 precursor Size: 999 amino acids; 111335 Da
Subunit: Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6,PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX
Subcellular location: Endoplasmic reticulum lumen
Secondary accessions: A8C1Z0 Q2I204 Q53H25Explore the universe of human proteins at neXtProt for HYOU1: NX_Q9Y4L1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y4L1
HYOU1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001124463.1 NP_006380.1
ENSEMBL proteins: ENSP00000384144 ENSP00000437313 ENSP00000433397 ENSP00000467866 ENSP00000431874 ENSP00000462951 ENSP00000463318 ENSP00000464026 ENSP00000463515 ENSP00000463742 ENSP00000462771 ENSP00000462510 ENSP00000442727 Reactome Protein details: Q9Y4L1
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
HYOU1 for ontologies About GeneDecksing
HYOU1 Antibody Products:
Assay Products for HYOU1: |
Protein
Domains /
Families
for HYOU1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HYOU1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y4L1ProtoNet protein and cluster: Q9Y4L1 UniProtKB/Swiss-Prot: HYOU1_HUMAN, Q9Y4L1Similarity: Belongs to the heat shock protein 70 family |
Function
for HYOU1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HYOU1_HUMAN, Q9Y4L1Function: Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role asa molecular chaperone and participate in protein foldingInduction: By hypoxia and also by 2-deoxyglucose or tunicamycin
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HYOU1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HYOU1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): HYOU1 (NM_006389) | |  | Sino Biological Human cDNA Clone for HYOU1 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HYOU1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HYOU1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HYOU1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005524 | ATP binding |
IEA | -- |
HYOU1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for HYOU1:
Animal Models:
Mouse knock-out Hyou1tm1Oga for HYOU1
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Hyou1):
HYOU1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for HYOU1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Activation of Chaperone Genes by XBP1(S) | | | 2 | Expression of HYOU1 | | | 3 | Protein processing in endoplasmic reticulum | | | 4 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for HYOU1
1 
Kegg Pathway (Kegg details for HYOU1):
HYOU1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HYOU1
5/17 Interacting proteins for HYOU1 (Q9Y4L13) via UniProtKB, MINT, STRING, and/or I2D (see all 17)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001666 | response to hypoxia |
-- | -- | | GO:0006950 | response to stress |
TAS | 9020069 | | GO:0006987 | activation of signaling protein activity involved in unfolded protein response |
TAS | -- | | GO:0030968 | endoplasmic reticulum unfolded protein response |
TAS | -- |
HYOU1 for ontologies About GeneDecksing
|
Drugs & Compounds
for HYOU1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HYOU1 for compounds About GeneDecksing
 Browse Tocris compounds for HYOU1
10/14 Novoseek chemical compound relationships for HYOU1 gene (see all 14) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hemocyanin |
71.6 |
6 |
8015442 (1), 10486145 (1), 11900522 (1), 9614947 (1) (see all 5) |
| oxygen |
59.2 |
62 |
10037731 (3), 9510522 (3), 15039052 (2), 10486145 (2) (see all 43) |
| tunicamycin |
47.2 |
1 |
9020069 (1) |
| vegf |
29.6 |
19 |
11435456 (4), 12445237 (4), 11358846 (4), 12175409 (2) (see all 5) |
| 2-deoxyglucose |
25.5 |
2 |
9020069 (1), 8878445 (1) |
| h2o2 |
2.19 |
2 |
8878445 (1), 8791091 (1) |
| glucose |
1.53 |
3 |
17588139 (2), 19225868 (1) |
| oligonucleotide |
0 |
1 |
8878445 (1) |
| atp |
0 |
3 |
10037731 (1), 9020069 (1) |
| calcium |
0 |
19 |
11714735 (2), 18404158 (2), 17167033 (2) |
Search CenterWatch for drugs/clinical trials and news about HYOU1
|
Transcripts
for HYOU1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HYOU1 gene (2 alternative transcripts): NM_001130991.1 NM_006389.3 Unigene Cluster for HYOU1: Hypoxia up-regulated 1 Hs.277704 [show with all ESTs]Unigene Representative Sequence: NM_00638918/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20): ENST00000404233(uc001put.2 uc001puw.1 uc001puu.2 uc001pux.3)
ENST00000529972(uc010ryu.1) ENST00000525859 ENST00000527738 ENST00000531682
ENST00000532519 ENST00000530473 ENST00000531694 ENST00000534233 ENST00000526656
ENST00000531968 ENST00000532421 ENST00000533381 ENST00000527038 ENST00000530467
ENST00000529174 ENST00000532752 ENST00000527310
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HYOU1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HYOU1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): HYOU1 (NM_006389) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HYOU1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HYOU1 |
Additional cDNA sequence: AK127324.1 AK222756.1 AK294905.1 AK297260.1 AK299648.1 AK301514.1 AK304264.1 AK307624.1 AK314178.1 BC004560.2 BC017726.1 BC072436.1 CR749610.1 DQ350134.1 DQ372932.1 U65785.1 24/27 DOTS entries (see all 27): DT.100647345 DT.100807389 DT.91769647 DT.120696292 DT.100039447 DT.100854346 DT.91769659 DT.95118170 DT.120696368 DT.120696403 DT.86851820 DT.100647347 DT.100647348 DT.91769661 DT.100647350 DT.120696287 DT.120696329 DT.87079107 DT.91769650 DT.100855944 DT.120696294 DT.120696320 DT.120696321 DT.75141709 24/674 AceView cDNA sequences (see all 674): AL582884 BP364120 AI084467 CA421931 AL039231 BF935032 AW188623 AL121015 AA018643 BP349139 AI401716 AA373551 T34985 CR601394 BP358069 CA443357 AI274132 BP365018 BU625931 BC017726 BP364597 BP356799 AI918980 CF528196
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for HYOU1 (see all 10) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ | 25a | · | 25b | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29a | · | 29b |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for HYOU1
|
Expression
for HYOU1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HYOU1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGTGAATGT
About this image
See HYOU1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HYOU1
SOURCE GeneReport for Unigene cluster: Hs.277704
UniProtKB/Swiss-Prot: HYOU1_HUMAN, Q9Y4L1Tissue specificity: Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize largeamounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Alsoexpressed in macrophages within aortic atherosclerotic plaques, and in breast cancers
SABiosciences Expression via Pathway-Focused PCR Array including HYOU1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HYOU1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HYOU1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HYOU1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HYOU1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HYOU1 |
Orthologs
for HYOU1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for HYOU1 gene from 9/32 species (see all 32) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
HYOU11 |
hypoxia up-regulated 1 |
68.83(n)
71.78(a) |
|
428251 NM_001006588.1 NP_001006588.1 |
lizard
(Anolis carolinensis) |
Reptilia |
HYOU16 |
-- |
69(a) |
1 ↔ 1 |
GL344273.1(37855-48279) |
African clawed frog
(Xenopus laevis) |
Amphibia |
LOC3985312 |
similar to calcium binding protein, 140 kDa |
75.11(n) |
|
BC043837.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.174622 |
Danio rerio mRNA similar to oxygen regulated protein more |
76.16(n) |
|
BC047807.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
EG:25E8.13
CG29181 |
chaperone3
CG29181 |
43(a)3
53.68(n)1
46.5(a)1 |
|
312151 NM_001169174.11 NP_001162645.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
T14G8.31 , 3 |
heat shock protein3
Protein T14G8.31 |
42(a)
(best of 2)3
49.56(n)1
38.35(a)1 |
|
X(12896462-12904697)3
1814221 NM_001029742.31 NP_001024913.11 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT4G166601 |
hypoxia up-regulated 1 |
45.57(n)
34.32(a) |
|
827367 NM_117767.3 NP_567510.1 |
rice
(Oryza sativa) |
Liliopsida |
Os02g07109001 |
hypothetical protein |
46.66(n)
34.85(a) |
|
4330492 NM_001054433.1 NP_001047898.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
hscC6 |
Hsp70 family chaperone Hsc62, binds to RpoD and in... |
20(a) |
1 → many |
Chromosome(680946-682616) |
ENSEMBL Gene Tree for HYOU1 (if available)
TreeFam Gene Tree for HYOU1 (if available) |
Paralogs
for HYOU1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HYOU1 gene
- HSPA4L2 HSPH12 HSPA42
12 SIMAP similar genes for HYOU1 using alignment to 14 protein entries: HYOU1_HUMAN (see all proteins):DKFZp686N08236 HSP70-1 HSPA1A HS24/p52 HS24/P52 HSPA7
LOC401308 HSPA8 HSPA1L HSPA4L HSPA14 HSPA4
HYOU1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for HYOU1
PGOHUM00000258579
|
Genomic Variants
for HYOU1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HYOU1 (118914896 - 118927925 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HYOU1
1 Indel: 58498 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HYOU1 |
|
Disorders
/ Diseases
for HYOU1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HYOU1 for disorders About GeneDecksing
OMIM gene information: 601746
OMIM disorders: --
18  diseases for HYOU1: About MalaCardshypoxia myocardial infarction acute myocardial infarction brain ischemia
insulin resistance ischemia proteinuria prostate cancer
hyperglycemia hepatocellular carcinoma lung carcinoma prostatitis
breast cancer carcinoma cerebritis pancreatitis
malaria neuronitis
10/11 Novoseek disease relationships for HYOU1 gene (see all 11) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| brain ischemia |
31.9 |
2 |
9748521 (2) |
| shock |
29.6 |
9 |
11905039 (1), 15952740 (1), 12445237 (1), 8878445 (1) (see all 7) |
| invasive cancer |
27.2 |
2 |
9645760 (1), 12445237 (1) |
| ischemia |
14.7 |
4 |
15240565 (1), 9748521 (1), 11231630 (1), 12172383 (1) |
| atherosclerotic plaque |
10.7 |
2 |
8878445 (2) |
| bladder cancer |
5.78 |
4 |
12175409 (2), 11771177 (1) |
| tumors |
2.35 |
17 |
11358846 (3), 9645760 (2), 17167033 (2), 9879341 (1) (see all 5) |
| myocardial infarction |
0 |
1 |
2290328 (1) |
| acute myocardial infarction |
0 |
1 |
17176249 (1) |
| prostate cancer |
0 |
3 |
12445237 (3) |
Genetic Association Database (GAD): HYOU1
Human Genome Epidemiology (HuGE) Navigator: HYOU1 (4 documents)
Export disorders for HYOU1 gene to outside databases
|
Publications
for HYOU1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HYOU1 gene, integrated from 9 sources (see all 113):
(articles sorted by number of sources associating them with HYOU1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- 150-kDa oxygen-regulated protein (ORP150) suppresses hypoxia-induced apoptotic cell death. (PubMed id 10037731)1, 2, 3, 9 Ozawa K....Tohyama M. (1999)
- Cloning and expression of cDNA encoding the human 150 kDa oxygen- regulated protein, ORP150. (PubMed id 9020069)1, 2, 3, 9 Ikeda J.... Yanagi H. (1997)
- Production of three distinct mRNAs of 150 kDa oxygen-regulated protein (ORP150) by alternative promoters: preferential induction of one species under stress conditions. (PubMed id 10965054)1, 2, 9 Kaneda S.... Yanagi H. (2000)
- Molecular cloning, sequence, function and structural basis of human heart 150 kDa oxygen-regulated protein, an ER chaperone. (PubMed id 17131193)1, 2, 9 Takeuchi S. (2006)
- Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)1, 2 Lewandrowski U.... Sickmann A. (2006)
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
- Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (2003)
- 150-kD oxygen-regulated protein is expressed in human atherosclerotic plaques and allows mononuclear phagocytes to withstand cellular stress on exposure to hypoxia and modified low density lipoprotein. (PubMed id 8878445)1, 9 Tsukamoto Y....Kitamura Y. (1996)
- ORP150/HSP12A protects renal tubular epithelium from ischemia-induced cell death. (PubMed id 15240565)1, 9 Bando Y....Ogawa S. (2004)
- ORP150 protects against hypoxia/ischemia-induced neuronal death. (PubMed id 11231630)1, 9 Tamatani M....Tohyama M. (2001)
|
External Searches for HYOU1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HYOU1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HYOU1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HYOU1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for HYOU1 gene:
Search GeneIP for patents involving HYOU1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HYOU1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for HYOU1 | | OriGene shRNA RFP for HYOU1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HYOU1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HYOU1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HYOU1 | | OriGene 3'-UTR Clone for HYOU1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HYOU1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HYOU1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HYOU1 | | OriGene Custom Protein Services for HYOU1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HYOU1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HYOU1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HYOU1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HYOU1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HYOU1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HYOU1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for HYOU1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | HYOU1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HYOU1 |
|  |  |  | | | | ThermoFisher Antibodies for HYOU1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HYOU1 |
|
|
|
|
