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Aliases for HYOU1 Gene

Aliases for HYOU1 Gene

  • Hypoxia Up-Regulated 1 2 3 5
  • 170 KDa Glucose-Regulated Protein 3 4
  • 150 KDa Oxygen-Regulated Protein 3 4
  • GRP-170 3 4
  • ORP-150 3 4
  • Grp170 3 4
  • ORP150 3 4
  • Oxygen Regulated Protein (150kD) 3
  • Glucose-Regulated Protein 170 2
  • HSP12A 3

External Ids for HYOU1 Gene

Previous GeneCards Identifiers for HYOU1 Gene

  • GC11P135580
  • GC11M120426
  • GC11M118948
  • GC11M118452
  • GC11M118420
  • GC11M114854
  • GC11M118914

Summaries for HYOU1 Gene

Entrez Gene Summary for HYOU1 Gene

  • The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for HYOU1 Gene

HYOU1 (Hypoxia Up-Regulated 1) is a Protein Coding gene. Diseases associated with HYOU1 include Hypoxia. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Unfolded Protein Response (UPR). GO annotations related to this gene include chaperone binding.

UniProtKB/Swiss-Prot for HYOU1 Gene

  • Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.

Gene Wiki entry for HYOU1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HYOU1 Gene

Genomics for HYOU1 Gene

Regulatory Elements for HYOU1 Gene

Enhancers for HYOU1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HYOU1 on UCSC Golden Path with GeneCards custom track

Promoters for HYOU1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HYOU1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the HYOU1 gene promoter:

Genomic Location for HYOU1 Gene

119,044,185 bp from pter
119,057,246 bp from pter
13,062 bases
Minus strand

Genomic View for HYOU1 Gene

Genes around HYOU1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HYOU1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HYOU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HYOU1 Gene

Proteins for HYOU1 Gene

  • Protein details for HYOU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hypoxia up-regulated protein 1
    Protein Accession:
    Secondary Accessions:
    • A8C1Z0
    • B7Z909
    • Q2I204
    • Q53H25

    Protein attributes for HYOU1 Gene

    999 amino acids
    Molecular mass:
    111335 Da
    Quaternary structure:
    • Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

    Alternative splice isoforms for HYOU1 Gene


neXtProt entry for HYOU1 Gene

Proteomics data for HYOU1 Gene at MOPED

Post-translational modifications for HYOU1 Gene

  • Ubiquitination at Lys 398
  • Glycosylation at Asn 155, Asn 222, Asn 515, Thr 580, Asn 596, Asn 830, Asn 862, Asn 869, Asn 922, and Asn 931
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for HYOU1 (ORP150/HSP12A)
  • Cell Signaling Technology (CST) Antibodies for HYOU1 (HYOU1)

No data available for DME Specific Peptides for HYOU1 Gene

Domains & Families for HYOU1 Gene

Gene Families for HYOU1 Gene

Protein Domains for HYOU1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the heat shock protein 70 family.
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HYOU1: view

Function for HYOU1 Gene

Molecular function for HYOU1 Gene

UniProtKB/Swiss-Prot Function:
Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.
UniProtKB/Swiss-Prot Induction:
By hypoxia and also by 2-deoxyglucose or tunicamycin.

Gene Ontology (GO) - Molecular Function for HYOU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with HYOU1: view
genes like me logo Genes that share phenotypes with HYOU1: view

Animal Models for HYOU1 Gene

MGI Knock Outs for HYOU1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HYOU1 Gene

Localization for HYOU1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HYOU1 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

Jensen Localization Image for HYOU1 Gene COMPARTMENTS Subcellular localization image for HYOU1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
golgi apparatus 2
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for HYOU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005925 focal adhesion IDA 21423176
GO:0034663 endoplasmic reticulum chaperone complex IEA --
genes like me logo Genes that share ontologies with HYOU1: view

Pathways & Interactions for HYOU1 Gene

genes like me logo Genes that share pathways with HYOU1: view

Interacting Proteins for HYOU1 Gene

Gene Ontology (GO) - Biological Process for HYOU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis TAS --
GO:0030968 endoplasmic reticulum unfolded protein response TAS --
GO:0034976 response to endoplasmic reticulum stress IEP 9020069
GO:0036498 IRE1-mediated unfolded protein response TAS --
GO:0043066 negative regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with HYOU1: view

No data available for SIGNOR curated interactions for HYOU1 Gene

Drugs & Compounds for HYOU1 Gene

(4) Drugs for HYOU1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(10) Additional Compounds for HYOU1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HYOU1: view

Transcripts for HYOU1 Gene

Unigene Clusters for HYOU1 Gene

Hypoxia up-regulated 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HYOU1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - -
SP2: - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: -
SP7: - -
SP8: - - -

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b
SP1: - -
SP2: - -

Relevant External Links for HYOU1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HYOU1 Gene

mRNA expression in normal human tissues for HYOU1 Gene

mRNA differential expression in normal tissues according to GTEx for HYOU1 Gene

This gene is overexpressed in Liver (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for HYOU1 Gene

SOURCE GeneReport for Unigene cluster for HYOU1 Gene Hs.277704

mRNA Expression by UniProt/SwissProt for HYOU1 Gene

Tissue specificity: Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers.
genes like me logo Genes that share expression patterns with HYOU1: view

Protein tissue co-expression partners for HYOU1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein differential expression in normal tissues for HYOU1 Gene

Orthologs for HYOU1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HYOU1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HYOU1 35
  • 89.31 (n)
  • 91.88 (a)
HYOU1 36
  • 92 (a)
(Canis familiaris)
Mammalia HYOU1 35
  • 89.46 (n)
  • 93.17 (a)
HYOU1 36
  • 93 (a)
(Mus musculus)
Mammalia Hyou1 35
  • 87.55 (n)
  • 92.09 (a)
Hyou1 16
Hyou1 36
  • 92 (a)
(Pan troglodytes)
Mammalia HYOU1 35
  • 99.14 (n)
  • 98.7 (a)
HYOU1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Hyou1 35
  • 88.21 (n)
  • 92.38 (a)
(Monodelphis domestica)
Mammalia HYOU1 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 26 (a)
(Gallus gallus)
Aves HYOU1 35
  • 69.35 (n)
  • 72.07 (a)
HYOU1 36
  • 71 (a)
(Anolis carolinensis)
Reptilia HYOU1 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hyou1 35
  • 67.8 (n)
  • 70.43 (a)
Str.3875 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398531 35
(Danio rerio)
Actinopterygii Dr.17462 35
hyou1 35
  • 67.31 (n)
  • 69.54 (a)
hyou1 36
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta EG:25E8.1 37
  • 43 (a)
CG2918 35
  • 54.34 (n)
  • 47.02 (a)
CG2918 36
  • 44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001827 35
  • 54.22 (n)
  • 46.13 (a)
(Caenorhabditis elegans)
Secernentea T14G8.3 37
  • 42 (a)
T24H7.2 37
  • 34 (a)
T14G8.3 35
  • 49.73 (n)
  • 39.09 (a)
T14G8.3 36
  • 36 (a)
T24H7.2 36
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSE1 36
  • 27 (a)
SSE2 36
  • 25 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G16660 35
  • 47.8 (n)
  • 38.39 (a)
(Oryza sativa)
Liliopsida Os02g0710900 35
  • 47.36 (n)
  • 35.39 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4458 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9387 36
  • 43 (a)
Species with no ortholog for HYOU1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HYOU1 Gene

Gene Tree for HYOU1 (if available)
Gene Tree for HYOU1 (if available)

Paralogs for HYOU1 Gene Pseudogenes for HYOU1 Gene

genes like me logo Genes that share paralogs with HYOU1: view

No data available for Paralogs for HYOU1 Gene

Variants for HYOU1 Gene

Sequence variations from dbSNP and Humsavar for HYOU1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs519942 -- 119,050,594(-) ATACG(C/T)ATGTG intron-variant
rs538478 -- 119,054,629(-) TTCAA(C/T)CAGGC nc-transcript-variant, reference, synonymous-codon
rs542258 -- 119,058,442(+) AAAGG(C/G)CCGCT upstream-variant-2KB
rs555551 -- 119,045,594(-) GGGGT(A/T)ATAGT nc-transcript-variant, reference, stop-lost
rs568922 -- 119,048,494(-) GAAGC(A/G)TTCAT nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for HYOU1 Gene

Variant ID Type Subtype PubMed ID
nsv898416 CNV Loss 21882294
nsv819696 CNV Loss 19587683

Variation tolerance for HYOU1 Gene

Residual Variation Intolerance Score: 6.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.40% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HYOU1 Gene

Disorders for HYOU1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HYOU1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
- elite association - COSMIC cancer census association via MalaCards
Search HYOU1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HYOU1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HYOU1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HYOU1 Gene

Publications for HYOU1 Gene

  1. 150-kDa oxygen-regulated protein (ORP150) suppresses hypoxia-induced apoptotic cell death. (PMID: 10037731) Ozawa K. … Tohyama M. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Cloning and expression of cDNA encoding the human 150 kDa oxygen- regulated protein, ORP150. (PMID: 9020069) Ikeda J. … Yanagi H. (Biochem. Biophys. Res. Commun. 1997) 2 3 23
  3. Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: prevention by oxygen-regulated protein 150 expression. (PMID: 19106412) Sanson M. … NA"gre-Salvayre A. (Circ. Res. 2009) 3 23
  4. The effect of glucose deprivation on collagen synthesis in fibroblast cultures. (PMID: 19225868) Cechowska-Pasko M. … BaA8kowski E. (Mol. Cell. Biochem. 2009) 3 23
  5. Oxygen-regulated protein-150 prevents calcium homeostasis deregulation and apoptosis induced by oxidized LDL in vascular cells. (PMID: 18404158) Sanson M. … NA"gre-Salvayre A. (Cell Death Differ. 2008) 3 23

Products for HYOU1 Gene

Sources for HYOU1 Gene