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Aliases for HYOU1 Gene

Aliases for HYOU1 Gene

  • Hypoxia Up-Regulated 1 2 3 5
  • 170 KDa Glucose-Regulated Protein 3 4
  • 150 KDa Oxygen-Regulated Protein 3 4
  • GRP-170 3 4
  • ORP-150 3 4
  • Grp170 3 4
  • ORP150 3 4
  • Oxygen Regulated Protein (150kD) 3
  • Hypoxia Up-Regulated Protein 1 3
  • Glucose-Regulated Protein 170 2
  • HSP12A 3

External Ids for HYOU1 Gene

Previous GeneCards Identifiers for HYOU1 Gene

  • GC11P135580
  • GC11M120426
  • GC11M118948
  • GC11M118452
  • GC11M118420
  • GC11M114854
  • GC11M118914

Summaries for HYOU1 Gene

Entrez Gene Summary for HYOU1 Gene

  • The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for HYOU1 Gene

HYOU1 (Hypoxia Up-Regulated 1) is a Protein Coding gene. Diseases associated with HYOU1 include Hypoxia and Ischemia. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Protein processing in endoplasmic reticulum. GO annotations related to this gene include chaperone binding.

UniProtKB/Swiss-Prot for HYOU1 Gene

  • Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.

Gene Wiki entry for HYOU1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HYOU1 Gene

Genomics for HYOU1 Gene

Regulatory Elements for HYOU1 Gene

Enhancers for HYOU1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G119076 0.6 ENCODE 12.7 -20.7 -20684 2.5 CTCF ZNF316 ZNF146 KDM1A EMSY MAFK VPS11 HMBS C2CD2L DPAGT1 HYOU1 ENSG00000255114 SLC37A4 RPS25 TRAPPC4 HINFP
GH11G119741 1.3 Ensembl ENCODE dbSUPER 5.1 -685.0 -685026 2.2 HDGF CTCF RB1 ZSCAN4 ZNF48 RAD21 ZFHX2 GLIS2 POLR2A PATZ1 LOC102724301 HYOU1 GC11P119746
GH11G118906 2.1 FANTOM5 Ensembl ENCODE dbSUPER 2.9 +138.5 138454 24.6 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC BCL9L CCDC84 CXCR5 DPAGT1 HMBS FOXR1 ENSG00000222529 C2CD2L ENSG00000254909 RNF26
GH11G119055 1.2 ENCODE 0.7 +0.1 109 3.0 CREB3L1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D SSRP1 VPS11 HINFP HMBS HYOU1 PIR44546
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HYOU1 on UCSC Golden Path with GeneCards custom track

Promoters for HYOU1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000045718 146 1801 HNRNPUL1 HDGF FOXA2 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2

Transcription factor binding sites by QIAGEN in the HYOU1 gene promoter:

Genomic Location for HYOU1 Gene

Chromosome:
11
Start:
119,044,185 bp from pter
End:
119,057,246 bp from pter
Size:
13,062 bases
Orientation:
Minus strand

Genomic View for HYOU1 Gene

Genes around HYOU1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HYOU1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HYOU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HYOU1 Gene

Proteins for HYOU1 Gene

  • Protein details for HYOU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4L1-HYOU1_HUMAN
    Recommended name:
    Hypoxia up-regulated protein 1
    Protein Accession:
    Q9Y4L1
    Secondary Accessions:
    • A8C1Z0
    • B7Z909
    • Q2I204
    • Q53H25

    Protein attributes for HYOU1 Gene

    Size:
    999 amino acids
    Molecular mass:
    111335 Da
    Quaternary structure:
    • Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

    Alternative splice isoforms for HYOU1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HYOU1 Gene

Post-translational modifications for HYOU1 Gene

  • Ubiquitination at posLast=398398
  • Glycosylation at posLast=155155, posLast=222222, posLast=515515, posLast=580580, isoforms=2596, posLast=830830, isoforms=862, posLast=869869, posLast=922922, and isoforms=931
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for HYOU1 (ORP150/HSP12A)
  • Cell Signaling Technology (CST) Antibodies for HYOU1 (HYOU1)
  • Abcam antibodies for HYOU1
  • Cloud-Clone Corp. Antibodies for HYOU1

No data available for DME Specific Peptides for HYOU1 Gene

Domains & Families for HYOU1 Gene

Gene Families for HYOU1 Gene

Protein Domains for HYOU1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y4L1

UniProtKB/Swiss-Prot:

HYOU1_HUMAN :
  • Belongs to the heat shock protein 70 family.
Family:
  • Belongs to the heat shock protein 70 family.
genes like me logo Genes that share domains with HYOU1: view

Function for HYOU1 Gene

Molecular function for HYOU1 Gene

UniProtKB/Swiss-Prot Function:
Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.
UniProtKB/Swiss-Prot Induction:
By hypoxia and also by 2-deoxyglucose or tunicamycin.

Gene Ontology (GO) - Molecular Function for HYOU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0051087 chaperone binding ISS 10837345
genes like me logo Genes that share ontologies with HYOU1: view
genes like me logo Genes that share phenotypes with HYOU1: view

Animal Models for HYOU1 Gene

MGI Knock Outs for HYOU1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HYOU1 Gene

Localization for HYOU1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HYOU1 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HYOU1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
golgi apparatus 2
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HYOU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005783 endoplasmic reticulum NAS 9020069
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005790 smooth endoplasmic reticulum ISS --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with HYOU1: view

Pathways & Interactions for HYOU1 Gene

genes like me logo Genes that share pathways with HYOU1: view

Interacting Proteins for HYOU1 Gene

Gene Ontology (GO) - Biological Process for HYOU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002931 response to ischemia ISS,IEA --
GO:0006888 ER to Golgi vesicle-mediated transport IDA 10837345
GO:0006898 receptor-mediated endocytosis TAS --
GO:0034976 response to endoplasmic reticulum stress IEP 9020069
GO:0036498 IRE1-mediated unfolded protein response TAS --
genes like me logo Genes that share ontologies with HYOU1: view

No data available for SIGNOR curated interactions for HYOU1 Gene

Drugs & Compounds for HYOU1 Gene

(7) Drugs for HYOU1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(7) Additional Compounds for HYOU1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HYOU1: view

Transcripts for HYOU1 Gene

Unigene Clusters for HYOU1 Gene

Hypoxia up-regulated 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HYOU1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - -
SP2: - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: -
SP7: - -
SP8: - - -
SP9:
SP10:

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for HYOU1 Gene

GeneLoc Exon Structure for
HYOU1
ECgene alternative splicing isoforms for
HYOU1

Expression for HYOU1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HYOU1 Gene

mRNA differential expression in normal tissues according to GTEx for HYOU1 Gene

This gene is overexpressed in Liver (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HYOU1 Gene



Protein tissue co-expression partners for HYOU1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HYOU1 Gene:

HYOU1

SOURCE GeneReport for Unigene cluster for HYOU1 Gene:

Hs.277704

mRNA Expression by UniProt/SwissProt for HYOU1 Gene:

Q9Y4L1-HYOU1_HUMAN
Tissue specificity: Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers.

Evidence on tissue expression from TISSUES for HYOU1 Gene

  • Nervous system(5)
  • Liver(4.7)
  • Blood(4.4)
  • Heart(4.4)
  • Bone marrow(4.3)
  • Kidney(3.9)
  • Lung(3.9)
  • Intestine(3.3)
  • Pancreas(2.6)
  • Spleen(2.3)
  • Lymph node(2.1)
  • Skin(2.1)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with HYOU1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HYOU1 Gene

Orthologs for HYOU1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HYOU1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HYOU1 34 35
  • 99.14 (n)
dog
(Canis familiaris)
Mammalia HYOU1 34 35
  • 89.46 (n)
cow
(Bos Taurus)
Mammalia HYOU1 34 35
  • 89.31 (n)
rat
(Rattus norvegicus)
Mammalia Hyou1 34
  • 88.21 (n)
mouse
(Mus musculus)
Mammalia Hyou1 34 16 35
  • 87.55 (n)
oppossum
(Monodelphis domestica)
Mammalia HYOU1 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 26 (a)
ManyToMany
chicken
(Gallus gallus)
Aves HYOU1 34 35
  • 69.35 (n)
lizard
(Anolis carolinensis)
Reptilia HYOU1 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hyou1 34
  • 67.8 (n)
Str.3875 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398531 34
zebrafish
(Danio rerio)
Actinopterygii hyou1 34 35
  • 67.31 (n)
Dr.17462 34
fruit fly
(Drosophila melanogaster)
Insecta CG2918 34 35
  • 54.34 (n)
EG:25E8.1 36
  • 43 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001827 34
  • 54.22 (n)
worm
(Caenorhabditis elegans)
Secernentea T14G8.3 36 34 35
  • 49.73 (n)
T24H7.2 36 35
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSE1 35
  • 27 (a)
ManyToMany
SSE2 35
  • 25 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G16660 34
  • 47.8 (n)
rice
(Oryza sativa)
Liliopsida Os02g0710900 34
  • 47.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9387 35
  • 43 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4458 34
Species where no ortholog for HYOU1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HYOU1 Gene

ENSEMBL:
Gene Tree for HYOU1 (if available)
TreeFam:
Gene Tree for HYOU1 (if available)

Paralogs for HYOU1 Gene

No data available for Paralogs for HYOU1 Gene

Variants for HYOU1 Gene

Sequence variations from dbSNP and Humsavar for HYOU1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000010527 -- 119,058,378(+) TGTGG(A/T)TGGAA upstream-variant-2KB
rs1000069607 -- 119,045,393(+) AGTTT(C/T)CATTT nc-transcript-variant, utr-variant-3-prime
rs1000239980 -- 119,053,387(+) AGACC(G/T)TGAAG intron-variant
rs1000253955 -- 119,058,710(+) AGGTC(A/G)GCAGA upstream-variant-2KB
rs1000373735 -- 119,047,352(+) GAATA(C/T)TCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HYOU1 Gene

Variant ID Type Subtype PubMed ID
nsv819696 CNV loss 19587683
nsv952745 CNV deletion 24416366

Variation tolerance for HYOU1 Gene

Residual Variation Intolerance Score: 6.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HYOU1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HYOU1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HYOU1 Gene

Disorders for HYOU1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HYOU1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypoxia
ischemia
  • acute coronary syndrome
- elite association - COSMIC cancer census association via MalaCards
Search HYOU1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HYOU1

Genetic Association Database (GAD)
HYOU1
Human Genome Epidemiology (HuGE) Navigator
HYOU1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HYOU1
genes like me logo Genes that share disorders with HYOU1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HYOU1 Gene

Publications for HYOU1 Gene

  1. 150-kDa oxygen-regulated protein (ORP150) suppresses hypoxia-induced apoptotic cell death. (PMID: 10037731) Ozawa K. … Tohyama M. (J. Biol. Chem. 1999) 2 3 4 22 64
  2. Cloning and expression of cDNA encoding the human 150 kDa oxygen- regulated protein, ORP150. (PMID: 9020069) Ikeda J. … Yanagi H. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 22 64
  3. Molecular cloning, sequence, function and structural basis of human heart 150 kDa oxygen-regulated protein, an ER chaperone. (PMID: 17131193) Takeuchi S. (Protein J. 2006) 3 4 22 64
  4. Production of three distinct mRNAs of 150 kDa oxygen-regulated protein (ORP150) by alternative promoters: preferential induction of one species under stress conditions. (PMID: 10965054) Kaneda S. … Yanagi H. (J. Biochem. 2000) 3 4 22 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for HYOU1 Gene

Sources for HYOU1 Gene

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