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HYOU1 Gene

protein-coding   GIFtS: 61
GCID: GC11M118914

Hypoxia Up-Regulated 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hypoxia Up-Regulated 11 2     Glucose-Regulated Protein 1701
150 KDa Oxygen-Regulated Protein2 3     Grp1702
170 KDa Glucose-Regulated Protein2 3     HSP12A2
GRP-1702 3     Hypoxia Up-Regulated Protein 12
ORP-1502 3     Oxygen Regulated Protein (150kD)2
ORP1502 3     GRP1703

External Ids:    HGNC: 169311   Entrez Gene: 105252   Ensembl: ENSG000001494287   OMIM: 6017465   UniProtKB: Q9Y4L13   

Export aliases for HYOU1 gene to outside databases

Previous GC identifers: GC11P135580 GC11M120426 GC11M118948 GC11M118452 GC11M118420 GC11M114854


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HYOU1 Gene:
The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative
transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction,
resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The
protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER.
Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an
important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be
up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene
also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal
peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the
ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a
carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Mar 2014)

GeneCards Summary for HYOU1 Gene:
HYOU1 (hypoxia up-regulated 1) is a protein-coding gene. Diseases associated with HYOU1 include hypoxia, and brain ischemia. An important paralog of this gene is HSPA4L.

UniProtKB/Swiss-Prot: HYOU1_HUMAN, Q9Y4L1
Function: Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a
role as a molecular chaperone and participate in protein folding

Gene Wiki entry for HYOU1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HYOU1 gene promoter:
         p53   MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHYOU1 promoter sequence
   Search Chromatin IP Primers for HYOU1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HYOU1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.1-q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.1-q23.3

HYOU1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HYOU1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M118914:  view genomic region     (about GC identifiers)

Start:
118,914,896 bp from pter      End:
118,927,925 bp from pter
Size:
13,030 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HYOU1_HUMAN, Q9Y4L1 (See protein sequence)
Recommended Name: Hypoxia up-regulated protein 1 precursor  
Size: 999 amino acids; 111335 Da
Subunit: Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4,
PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX
Secondary accessions: A8C1Z0 Q2I204 Q53H25

Explore the universe of human proteins at neXtProt for HYOU1: NX_Q9Y4L1

Explore proteomics data for HYOU1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys398
  • Glycosylation2 at Asn155, Asn222, Asn515, Thr580, Thr589, Thr590, Asn596, Asn830, Asn862, Asn869,
                                 Asn922, Asn931
  • Modification sites at PhosphoSitePlus

  • See HYOU1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001124463.1  NP_006380.1  

    ENSEMBL proteins: 
     ENSP00000384144   ENSP00000437313   ENSP00000433397   ENSP00000467866   ENSP00000431874  
     ENSP00000462951   ENSP00000463318   ENSP00000464026   ENSP00000463515   ENSP00000463742  
     ENSP00000462771   ENSP00000462510   ENSP00000442727  
    Reactome Protein details: Q9Y4L1

    HYOU1 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HYOU1
    GenScript Custom Purified and Recombinant Proteins Services for HYOU1
    Novus Biologicals HYOU1 Proteins
    Novus Biologicals HYOU1 Lysate
    Sino Biological Recombinant Protein for HYOU1
    Sino Biological Cell Lysate for HYOU1
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HYOU1

    HYOU1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for HYOU1 (ORP150/HSP12A)
    OriGene Antibodies for HYOU1
    OriGene Custom Antibody Services for HYOU1
    Novus Biologicals HYOU1 Antibodies
    Abcam antibodies for HYOU1
    Cloud-Clone Corp. Antibodies for HYOU1
    ThermoFisher Antibody for HYOU1
    LSBio Antibodies in human, mouse, rat for HYOU1

    HYOU1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HYOU1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HYOU1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HYOU1
    Cloud-Clone Corp. CLIAs for HYOU1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HSP70: Heat shock proteins / HSP70

    2 InterPro protein domains:
     IPR018181 Heat_shock_70_CS
     IPR013126 Hsp_70_fam

    Graphical View of Domain Structure for InterPro Entry Q9Y4L1

    ProtoNet protein and cluster: Q9Y4L1

    UniProtKB/Swiss-Prot: HYOU1_HUMAN, Q9Y4L1
    Similarity: Belongs to the heat shock protein 70 family


    HYOU1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HYOU1_HUMAN, Q9Y4L1
    Function: Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a
    role as a molecular chaperone and participate in protein folding
    Induction: By hypoxia and also by 2-deoxyglucose or tunicamycin

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
         
    HYOU1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HYOU1:
     Cell cycle / mitosis defect 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hyou1):
     behavior/neurological  cellular  homeostasis/metabolism  mortality/aging  nervous system 

    HYOU1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hyou1tm1Oga for HYOU1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HYOU1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HYOU1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HYOU1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HYOU1

    miRNA
    Products:
        
    miRTarBase miRNAs that target HYOU1:
    hsa-mir-455-3p (MIRT037898), hsa-mir-484 (MIRT041955), hsa-mir-615-3p (MIRT040395), hsa-mir-193b-3p (MIRT016306), hsa-mir-183-5p (MIRT047102), hsa-mir-335-5p (MIRT016902), hsa-mir-1296-5p (MIRT036087), hsa-mir-93-3p (MIRT038859), hsa-mir-766-3p (MIRT039029)

    Block miRNA regulation of human, mouse, rat HYOU1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HYOU1 (see all 34):
    hsa-miR-193a-3p hsa-miR-429 hsa-miR-548k hsa-miR-128 hsa-miR-1245 hsa-miR-4275 hsa-miR-649 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidHYOU1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HYOU1
    Predesigned siRNA for gene silencing in human, mouse, rat HYOU1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HYOU1

    Clone
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    OriGene clones in human, mouse for HYOU1 (see all 13)
    OriGene ORF clones in mouse, rat for HYOU1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HYOU1 (NM_006389)
    Sino Biological Human cDNA Clone for HYOU1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HYOU1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HYOU1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for HYOU1
    Browse ESI BIO Cell Lines and PureStem Progenitors for HYOU1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HYOU1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HYOU1_HUMAN, Q9Y4L1: Endoplasmic reticulum lumen
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus2
    extracellular1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005783endoplasmic reticulum TAS9020069
    GO:0005788endoplasmic reticulum lumen TAS--
    GO:0070062extracellular vesicular exosome IDA19199708
    GO:0071682endocytic vesicle lumen TAS--

    HYOU1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HYOU1 About    
    See pathways by source

    SuperPathContained pathways About
    1Unfolded Protein Response
    Unfolded Protein Response0.61
    Activation of Chaperone Genes by XBP1(S)0.59
    Activation of Chaperones by IRE1alpha0.61
    2Binding and Uptake of Ligands by Scavenger Receptors
    Binding and Uptake of Ligands by Scavenger Receptors0.53
    Scavenging by Class F Receptors0.00
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    4Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for HYOU1
        XBP1(S) activates chaperone genes
    Scavenging by Class F Receptors


    1 Kegg Pathway  (Kegg details for HYOU1):
        Protein processing in endoplasmic reticulum


    HYOU1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including HYOU1: 
              Hepatotoxicity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HYOU1

    Selected Interacting proteins for HYOU1 (Q9Y4L13) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206505P304503I2D: score=1 I2D: score=1 
    HLA-AP304503I2D: score=1 I2D: score=1 
    EXT2Q930633I2D: score=2 
    H2AFXP161043I2D: score=2 
    IKBKEQ141643I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000902cell morphogenesis ----
    GO:0002931response to ischemia IEA--
    GO:0006950response to stress TAS9020069
    GO:0006987activation of signaling protein activity involved in unfolded protein response TAS--
    GO:0030968endoplasmic reticulum unfolded protein response TAS--

    HYOU1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HYOU1

    Selected Novoseek inferred chemical compound relationships for HYOU1 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hemocyanin 71.6 6 8015442 (1), 10486145 (1), 11900522 (1), 9614947 (1) (see all 5)
    oxygen 59.2 62 10037731 (3), 9510522 (3), 15039052 (2), 10486145 (2) (see all 43)
    tunicamycin 47.2 1 9020069 (1)
    vegf 29.6 19 11435456 (4), 12445237 (4), 11358846 (4), 12175409 (2) (see all 5)
    2-deoxyglucose 25.5 2 9020069 (1), 8878445 (1)
    h2o2 2.19 2 8878445 (1), 8791091 (1)
    glucose 1.53 3 17588139 (2), 19225868 (1)
    oligonucleotide 0 1 8878445 (1)
    atp 0 3 10037731 (1), 9020069 (1)
    calcium 0 19 11714735 (2), 18404158 (2), 17167033 (2)



    HYOU1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HYOU1 gene (2 alternative transcripts): 
    NM_001130991.2  NM_006389.4  

    Unigene Cluster for HYOU1:

    Hypoxia up-regulated 1
    Hs.277704  [show with all ESTs]
    Unigene Representative Sequence: NM_006389
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000404233(uc001put.2 uc001puw.1 uc001puu.2 uc001pux.3)
    ENST00000529972(uc010ryu.1) ENST00000525859 ENST00000527738 ENST00000531682
    ENST00000532519 ENST00000530473 ENST00000531694 ENST00000534233 ENST00000526656
    ENST00000531968 ENST00000532421 ENST00000533381 ENST00000527038 ENST00000530467
    ENST00000529174 ENST00000532752 ENST00000527310
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HYOU1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HYOU1 (see all 34):
    hsa-miR-193a-3p hsa-miR-429 hsa-miR-548k hsa-miR-128 hsa-miR-1245 hsa-miR-4275 hsa-miR-649 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidHYOU1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HYOU1
    Predesigned siRNA for gene silencing in human, mouse, rat HYOU1
    Clone
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    OriGene clones in human, mouse for HYOU1 (see all 13)
    OriGene ORF clones in mouse, rat for HYOU1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HYOU1 (NM_006389)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HYOU1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HYOU1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for HYOU1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HYOU1
      QuantiTect SYBR Green Assays in human, mouse, rat HYOU1
      QuantiFast Probe-based Assays in human, mouse, rat HYOU1

    Additional mRNA sequence: 

    AK127324.1 AK222756.1 AK294905.1 AK297260.1 AK299648.1 AK301514.1 AK304264.1 AK307624.1 
    AK314178.1 BC004560.2 BC017726.1 BC072436.1 CR749610.1 DQ350134.1 DQ372932.1 U65785.1 

    Selected DOTS entries (see all 27):

    DT.100647345  DT.100807389  DT.91769647  DT.120696292  DT.100039447  DT.100854346  DT.91769659  DT.95118170 
    DT.120696368  DT.120696403  DT.86851820  DT.100647347  DT.100647348  DT.91769661  DT.100647350  DT.120696287 
    DT.120696329  DT.87079107  DT.91769650  DT.100855944  DT.120696294  DT.120696320  DT.120696321  DT.75141709 

    Selected AceView cDNA sequences (see all 674):

    BP364597 BP358236 BU616565 CA488744 BP357037 T31874 BQ644081 AI084467 
    BM690167 BP365283 BP363293 AL039231 CR600509 BP364120 BP354253 AI918980 
    BP359121 BP356799 BQ445944 AL044681 BP364684 BP357242 AI874340 CF528196 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HYOU1 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
    SP1:                                            -     -     -                                   -                                                               
    SP2:                                            -     -     -                 -                 -                                                               
    SP3:        -     -     -     -     -     -     -     -     -                                   -                                                               
    SP4:                                -     -     -     -     -                                   -                                                               
    SP5:                                      -     -     -     -                                   -                                                               

    ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b
    SP1:                                            -                 -                                 
    SP2:                                            -                 -                                 
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for HYOU1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    HYOU1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTGAATGT
    HYOU1 Expression
    About this image

    HYOU1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HYOU1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.277704

    UniProtKB/Swiss-Prot: HYOU1_HUMAN, Q9Y4L1
    Tissue specificity: Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize
    large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and
    kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers

        Pathway & Disease-focused RT2 Profiler PCR Array including HYOU1: 
              Hepatotoxicity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HYOU1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hyou11 , 5 hypoxia up-regulated 11, 5 87.55(n)1
    92.09(a)1
      9 (24.84 cM)5
    122821  NM_021395.41  NP_067370.31 
     443794905 
    chicken
    (Gallus gallus)
    Aves HYOU11 hypoxia up-regulated 1 69.35(n)
    72.07(a)
      428251  NM_001006588.1  NP_001006588.1 
    lizard
    (Anolis carolinensis)
    Reptilia HYOU16
    hypoxia up-regulated 1
    69(a)
    1 ↔ 1
    GL344273.1(37855-48368)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985312 similar to calcium binding protein, 140 kDa 75.11(n)    BC043837.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.174622 Danio rerio mRNA similar to oxygen regulated protein more 76.16(n)    BC047807.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta EG:25E8.13
    CG29181
    chaperone3
    CG29181
    43(a)3
    54.34(n)1
    47.02(a)1
      312151  NM_001169174.11  NP_001162645.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T14G8.31 , 3 heat shock protein3
    T14G8.31
    42(a)
    (best of 2)3
    49.73(n)1
    39.09(a)1
      X(12896462-12904697)3
    1814221  NM_001029742.41  NP_001024913.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSE16
    SSE26
    ATPase that is a component of the heat shock prote...
    Member of the heat shock protein 70 (HSP70) family...
    27(a)
    25(a)
    many ↔ many
    many ↔ many
    XVI(350194-352275) YPL106C
    II(573915-575996) YBR169C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G166601 AT4G16660 47.8(n)
    38.39(a)
      827367  NM_117767.3  NP_567510.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g07109001 Os02g0710900 47.36(n)
    35.39(a)
      4330492  NM_001054433.1  NP_001047898.1 


    ENSEMBL Gene Tree for HYOU1 (if available)
    TreeFam Gene Tree for HYOU1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HYOU1 gene
    HSPA4L2  HSPH12  HSPA42  
    10 SIMAP similar genes for HYOU1 using alignment to 14 protein entries:     HYOU1_HUMAN (see all proteins):
    DKFZp686N08236    HSP70-1    HS24/p52    HS24/P52    HSPA7    LOC401308
    HSPA8    HSPA4L    HSPA14    HSPA4

    HYOU1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HYOU1
    PGOHUM00000258579


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HYOU1 (see all 525)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113793011,2
    C--118914417(+) AAAAAA/-AAAAA 2 -- ds50011Minor allele frequency- -:0.00NA 2
    rs789045991,2
    F--118914516(+) TTGAAA/GAAAAT 2 -- ds50012Minor allele frequency- G:0.04CSA WA 119
    rs25089521,2
    H--118914555(+) GTGTCA/CATAAC 2 -- ds50014Minor allele frequency- C:0.00NS EA 420
    rs1884105301,2
    --118914560(+) AATAAC/TATTTT 2 -- ds50010--------
    rs17843031,2
    C,H--118914589(+) ACTTTT/GTGAGG 2 -- ds50014Minor allele frequency- G:0.00NS EA 418
    rs1144129311,2
    F--118914597(+) AGGTTT/GTCACT 2 -- ds50011Minor allele frequency- G:0.04WA 118
    rs113584161,2
    C--118914738(+) TTTTTT/-GAGAC 2 -- ds50011Minor allele frequency- -:0.50NA 2
    rs735609861,2
    C,F--118914891(+) ACAGCA/GCAAAA 2 -- ds50012Minor allele frequency- G:0.07WA 120
    rs1932192641,2
    --118914908(+) GAAAAG/TAATAT 2 -- ut310--------
    rs2003109471,2
    --118914923(+) TTGAA-/ACAGTTT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for HYOU1 (118914896 - 118927925 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HYOU1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819696CNV Loss19587683
    nsv898416CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HYOU1
    DNA2.0 Custom Variant and Variant Library Synthesis for HYOU1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601746    OMIM disorders: --

    17 diseases for HYOU1:    
    About MalaCards
    hypoxia    brain ischemia    ischemia    acute myocardial infarction
    myocardial infarction    proteinuria    hyperglycemia    insulin resistance
    type 1 diabetes    prostate cancer    prostatitis    cerebritis
    hepatocellular carcinoma    breast cancer    neuronitis    pancreatitis
    malaria


    HYOU1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for HYOU1 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    brain ischemia 31.9 2 9748521 (2)
    shock 29.6 9 11905039 (1), 15952740 (1), 12445237 (1), 8878445 (1) (see all 7)
    invasive cancer 27.2 2 9645760 (1), 12445237 (1)
    ischemia 14.7 4 15240565 (1), 9748521 (1), 11231630 (1), 12172383 (1)
    atherosclerotic plaque 10.7 2 8878445 (2)
    bladder cancer 5.78 4 12175409 (2), 11771177 (1)
    tumors 2.35 17 11358846 (3), 9645760 (2), 17167033 (2), 9879341 (1) (see all 5)
    myocardial infarction 0 1 2290328 (1)
    acute myocardial infarction 0 1 17176249 (1)
    prostate cancer 0 3 12445237 (3)

    Genetic Association Database (GAD): HYOU1
    Human Genome Epidemiology (HuGE) Navigator: HYOU1 (4 documents)

    Export disorders for HYOU1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HYOU1 gene, integrated from 10 sources (see all 118):
    (articles sorted by number of sources associating them with HYOU1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. 150-kDa oxygen-regulated protein (ORP150) suppresses hypoxia-induced apoptotic cell death. (PubMed id 10037731)1, 2, 3, 9 Ozawa K....Tohyama M. (J. Biol. Chem. 1999)
    2. Cloning and expression of cDNA encoding the human 150 kDa oxygen- regulated protein, ORP150. (PubMed id 9020069)1, 2, 3, 9 Ikeda J.... Yanagi H. (Biochem. Biophys. Res. Commun. 1997)
    3. Production of three distinct mRNAs of 150 kDa oxygen-regulated protein (ORP150) by alternative promoters: preferential induction of one species under stress conditions. (PubMed id 10965054)1, 2, 9 Kaneda S.... Yanagi H. (J. Biochem. 2000)
    4. Molecular cloning, sequence, function and structural basis of human heart 150 kDa oxygen-regulated protein, an ER chaperone. (PubMed id 17131193)1, 2, 9 Takeuchi S. (Protein J. 2006)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)1, 2 Lewandrowski U.... Sickmann A. (Mol. Cell. Proteomics 2006)
    7. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    8. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (Nat. Biotechnol. 2003)
    9. 150-kD oxygen-regulated protein is expressed in human atherosclerotic plaques and allows mononuclear phagocytes to withstand cellular stress on exposure to hypoxia and modified low density lipoprotein. (PubMed id 8878445)1, 9 Tsukamoto Y....Kitamura Y. (J. Clin. Invest. 1996)
    10. ORP150/HSP12A protects renal tubular epithelium from ischemia-induced cell death. (PubMed id 15240565)1, 9 Bando Y....Ogawa S. (FASEB J. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10525 HGNC: 16931 AceView: HYOU1 Ensembl:ENSG00000149428 euGenes: HUgn10525
    ECgene: HYOU1 Kegg: 10525 H-InvDB: HYOU1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HYOU1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HYOU1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HYOU1 gene:
    Search GeneIP for patents involving HYOU1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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