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Aliases for HYKK Gene

Aliases for HYKK Gene

  • Hydroxylysine Kinase 2 3 5
  • Aminoglycoside Phosphotransferase Domain-Containing Protein 1 3 4
  • 5-Hydroxy-L-Lysine Kinase 3 4
  • 5-Hydroxylysine Kinase 2 3
  • AGPHD1 3 4
  • Aminoglycoside Phosphotransferase Domain Containing 1 2
  • EC 2.7.1.81 4

External Ids for HYKK Gene

Previous HGNC Symbols for HYKK Gene

  • AGPHD1

Previous GeneCards Identifiers for HYKK Gene

  • GC15P078800

Summaries for HYKK Gene

GeneCards Summary for HYKK Gene

HYKK (Hydroxylysine Kinase) is a Protein Coding gene. Diseases associated with HYKK include Nicotine Dependence, Protection Against. Among its related pathways are Metabolism and Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and hydroxylysine kinase activity.

UniProtKB/Swiss-Prot for HYKK Gene

  • Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HYKK Gene

Genomics for HYKK Gene

Regulatory Elements for HYKK Gene

Enhancers for HYKK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F078871 1.1 ENCODE 25.1 +366.2 366244 4.6 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 IREB2 ENSG00000259562 HYKK WDR61 ENSG00000259322 TBC1D2B RNU6-415P ENSG00000260988 ENSG00000177699 ADAMTS7P3
GH15F078061 1.6 FANTOM5 ENCODE 14.1 -437.5 -437525 16.8 HDGF PKNOX1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ENSG00000259562 TBC1D2B LOC645752 HYKK IREB2 ENSG00000199633 ADAMTS7P3 LOC440292 HMG20A DNAJA4
GH15F078146 1.4 Ensembl ENCODE 12.8 -358.9 -358929 5.2 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF263 SP3 WDR61 IDH3A LOC105370911 LOC105370908 RN7SL214P LOC105370907 RPL18P11 LOC646938 LOC646853 ENSG00000259562
GH15F078298 1.1 ENCODE 14.1 -208.1 -208077 2.5 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 ENSG00000259562 ENSG00000259322 HYKK LOC645752 DNAJA4 ENSG00000277482
GH15F078436 1.1 ENCODE 13 -68.8 -68796 4.2 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 CHRNA5 WDR61 IREB2 ENSG00000259562 ENSG00000259322 TBC1D2B HYKK ENSG00000260988 ENSG00000259792 PSMA4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HYKK on UCSC Golden Path with GeneCards custom track

Promoters for HYKK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000128054 137 1799 ATF1 PKNOX1 CREB3L1 ARID4B SIN3A ZNF48 YY1 GLIS2 FOS ZNF263

Genomic Location for HYKK Gene

Chromosome:
15
Start:
78,507,564 bp from pter
End:
78,537,373 bp from pter
Size:
29,810 bases
Orientation:
Plus strand

Genomic View for HYKK Gene

Genes around HYKK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HYKK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HYKK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HYKK Gene

Proteins for HYKK Gene

  • Protein details for HYKK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RU49-HYKK_HUMAN
    Recommended name:
    Hydroxylysine kinase
    Protein Accession:
    A2RU49
    Secondary Accessions:
    • B7ZMA5
    • F8W6X5
    • Q6ZTN0

    Protein attributes for HYKK Gene

    Size:
    373 amino acids
    Molecular mass:
    41933 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HYKK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HYKK Gene

Post-translational modifications for HYKK Gene

  • Ubiquitination at Lys 186
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HYKK Gene

Domains & Families for HYKK Gene

Protein Domains for HYKK Gene

Suggested Antigen Peptide Sequences for HYKK Gene

Graphical View of Domain Structure for InterPro Entry

A2RU49

UniProtKB/Swiss-Prot:

HYKK_HUMAN :
  • Belongs to the aminoglycoside phosphotransferase family.
Family:
  • Belongs to the aminoglycoside phosphotransferase family.
genes like me logo Genes that share domains with HYKK: view

No data available for Gene Families for HYKK Gene

Function for HYKK Gene

Molecular function for HYKK Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=280 uM for (5R)-5-hydroxy-L-lysine (in the presence of 2 mM ATP) {ECO:0000269 PubMed:22241472}; KM=7.6 uM for (5R)-5-hydroxy-L-lysine (in the presence of 0.2 mM GTP) {ECO:0000269 PubMed:22241472}; KM=810 uM for ATP (in the presence of 0.5 mM (5R)-5-hydroxy-L- lysine) {ECO:0000269 PubMed:22241472}; KM=3.5 uM for GTP (in the presence of 0.5 mM (5R)-5-hydroxy-L- lysine) {ECO:0000269 PubMed:22241472}; Vmax=4.95 umol/min/mg enzyme toward (5R)-5-hydroxy-L-lysine (in the presence of 2 mM ATP) {ECO:0000269 PubMed:22241472}; Vmax=0.49 umol/min/mg enzyme toward (5R)-5-hydroxy-L-lysine (in the presence of 0.2 mM GTP) {ECO:0000269 PubMed:22241472}; Vmax=5.28 umol/min/mg enzyme toward ATP (in the presence of 0.5 mM (5R)-5-hydroxy-L-lysine) {ECO:0000269 PubMed:22241472}; Vmax=0.57 umol/min/mg enzyme toward GTP (in the presence of 0.5 mM (5R)-5-hydroxy-L-lysine) {ECO:0000269 PubMed:22241472};
UniProtKB/Swiss-Prot CatalyticActivity:
GTP + 5-hydroxy-L-lysine = GDP + 5-phosphonooxy-L-lysine.
UniProtKB/Swiss-Prot Function:
Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.

Enzyme Numbers (IUBMB) for HYKK Gene

Gene Ontology (GO) - Molecular Function for HYKK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
GO:0047992 hydroxylysine kinase activity IEA,TAS --
genes like me logo Genes that share ontologies with HYKK: view

Phenotypes for HYKK Gene

genes like me logo Genes that share phenotypes with HYKK: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HYKK Gene

Localization for HYKK Gene

Subcellular locations from UniProtKB/Swiss-Prot for HYKK Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HYKK gene
Compartment Confidence
mitochondrion 4
peroxisome 2
nucleus 2
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for HYKK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with HYKK: view

Pathways & Interactions for HYKK Gene

genes like me logo Genes that share pathways with HYKK: view

Interacting Proteins for HYKK Gene

Gene Ontology (GO) - Biological Process for HYKK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006554 lysine catabolic process TAS --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with HYKK: view

No data available for SIGNOR curated interactions for HYKK Gene

Drugs & Compounds for HYKK Gene

(2) Drugs for HYKK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for HYKK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Hydroxylysine
  • (2S,5R)-2,6-diamino-5-hydroxyhexanoate
  • (2S,5R)-2,6-diamino-5-hydroxyhexanoic acid
  • (2S,5R)-5-hydroxylysine
  • (5R)-5-hydroxy-L-lysine
  • 5-Hydroxy-L-lysine
1190-94-9
5-phosphonooxy-L-lysine
genes like me logo Genes that share compounds with HYKK: view

Transcripts for HYKK Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HYKK Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for HYKK Gene

GeneLoc Exon Structure for
HYKK
ECgene alternative splicing isoforms for
HYKK

Expression for HYKK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HYKK Gene

NURSA nuclear receptor signaling pathways regulating expression of HYKK Gene:

HYKK
genes like me logo Genes that share expression patterns with HYKK: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for HYKK Gene

Orthologs for HYKK Gene

This gene was present in the common ancestor of animals.

Orthologs for HYKK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGPHD1 34
  • 99.37 (n)
HYKK 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HYKK 34 35
  • 89.99 (n)
rat
(Rattus norvegicus)
Mammalia Hykk 34
  • 84.54 (n)
mouse
(Mus musculus)
Mammalia Hykk 34 16 35
  • 84 (n)
dog
(Canis familiaris)
Mammalia HYKK 34 35
  • 78.11 (n)
oppossum
(Monodelphis domestica)
Mammalia HYKK 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HYKK 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves AGPHD1 34 35
  • 62.85 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia hykk 34
  • 64.05 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:171550 34
  • 56.13 (n)
HYKK (1 of 2) 35
  • 47 (a)
OneToMany
HYKK (2 of 2) 35
  • 43 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004612 34
  • 45.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31751 34 35
  • 45.81 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToMany
-- 35
  • 27 (a)
OneToMany
-- 35
  • 23 (a)
OneToMany
Species where no ortholog for HYKK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HYKK Gene

ENSEMBL:
Gene Tree for HYKK (if available)
TreeFam:
Gene Tree for HYKK (if available)

Paralogs for HYKK Gene

No data available for Paralogs for HYKK Gene

Variants for HYKK Gene

Sequence variations from dbSNP and Humsavar for HYKK Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10519203 -- 78,521,704(+) AGTGA(A/G)TCCAC intron-variant
rs111325219 -- 78,515,413(+) ACCCC(A/G)TCTCT intron-variant
rs111375839 -- 78,527,391(+) CATCA(C/T)CCAAA nc-transcript-variant, reference, synonymous-codon, missense
rs111445177 -- 78,531,920(+) ACAGT(A/T)ATATT intron-variant
rs111650215 -- 78,535,741(+) GAGAT(A/G)GGGTC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HYKK Gene

Variant ID Type Subtype PubMed ID
nsv94512 CNV deletion 16902084
nsv1116464 OTHER inversion 24896259
nsv1038816 CNV gain 25217958
esv3636985 CNV loss 21293372
esv2749911 CNV deletion 23290073

Variation tolerance for HYKK Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.91; 67.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HYKK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HYKK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HYKK Gene

Disorders for HYKK Gene

MalaCards: The human disease database

(1) MalaCards diseases for HYKK Gene - From: DISEASES

Disorder Aliases PubMed IDs
nicotine dependence, protection against
  • nicotine dependence
- elite association - COSMIC cancer census association via MalaCards
Search HYKK in MalaCards View complete list of genes associated with diseases

Relevant External Links for HYKK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HYKK
genes like me logo Genes that share disorders with HYKK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HYKK Gene

Publications for HYKK Gene

  1. Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine. (PMID: 22241472) Veiga-da-Cunha M. … Van Schaftingen E. (J. Biol. Chem. 2012) 2 3 4 64
  2. Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. (PMID: 18780872) Liu P. … You M. (J. Natl. Cancer Inst. 2008) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Meta-analysis of the association between the rs8034191 polymorphism in AGPHD1 and lung cancer risk. (PMID: 25854352) Zhang L. … Chen C. (Asian Pac. J. Cancer Prev. 2015) 3 64
  5. Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns. (PMID: 25006744) Castaldi P.J. … Silverman E.K. (Am. J. Respir. Crit. Care Med. 2014) 3 64

Products for HYKK Gene

Sources for HYKK Gene

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