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Aliases for HYKK Gene

Aliases for HYKK Gene

  • Hydroxylysine Kinase 2 3 5
  • Aminoglycoside Phosphotransferase Domain-Containing Protein 1 3 4
  • 5-Hydroxy-L-Lysine Kinase 3 4
  • 5-Hydroxylysine Kinase 2 3
  • AGPHD1 3 4
  • Aminoglycoside Phosphotransferase Domain Containing 1 2
  • EC 2.7.1.81 4

External Ids for HYKK Gene

Previous HGNC Symbols for HYKK Gene

  • AGPHD1

Previous GeneCards Identifiers for HYKK Gene

  • GC15P078800

Summaries for HYKK Gene

GeneCards Summary for HYKK Gene

HYKK (Hydroxylysine Kinase) is a Protein Coding gene. Among its related pathways are Metabolism and Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and hydroxylysine kinase activity.

UniProtKB/Swiss-Prot for HYKK Gene

  • Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HYKK Gene

Genomics for HYKK Gene

Regulatory Elements for HYKK Gene

Promoters for HYKK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HYKK on UCSC Golden Path with GeneCards custom track

Genomic Location for HYKK Gene

Chromosome:
15
Start:
78,507,564 bp from pter
End:
78,537,373 bp from pter
Size:
29,810 bases
Orientation:
Plus strand

Genomic View for HYKK Gene

Genes around HYKK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HYKK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HYKK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HYKK Gene

Proteins for HYKK Gene

  • Protein details for HYKK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RU49-HYKK_HUMAN
    Recommended name:
    Hydroxylysine kinase
    Protein Accession:
    A2RU49
    Secondary Accessions:
    • B7ZMA5
    • F8W6X5
    • Q6ZTN0

    Protein attributes for HYKK Gene

    Size:
    373 amino acids
    Molecular mass:
    41933 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HYKK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HYKK Gene

Proteomics data for HYKK Gene at MOPED

Post-translational modifications for HYKK Gene

  • Ubiquitination at Lys 186
  • Modification sites at PhosphoSitePlus

Other Protein References for HYKK Gene

No data available for DME Specific Peptides for HYKK Gene

Domains & Families for HYKK Gene

Protein Domains for HYKK Gene

Suggested Antigen Peptide Sequences for HYKK Gene

Graphical View of Domain Structure for InterPro Entry

A2RU49

UniProtKB/Swiss-Prot:

HYKK_HUMAN :
  • Belongs to the aminoglycoside phosphotransferase family.
Family:
  • Belongs to the aminoglycoside phosphotransferase family.
genes like me logo Genes that share domains with HYKK: view

No data available for Gene Families for HYKK Gene

Function for HYKK Gene

Molecular function for HYKK Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=280 uM for (5R)-5-hydroxy-L-lysine (in the presence of 2 mM ATP) {ECO:0000269 PubMed:22241472}; KM=7.6 uM for (5R)-5-hydroxy-L-lysine (in the presence of 0.2 mM GTP) {ECO:0000269 PubMed:22241472}; KM=810 uM for ATP (in the presence of 0.5 mM (5R)-5-hydroxy-L- lysine) {ECO:0000269 PubMed:22241472}; KM=3.5 uM for GTP (in the presence of 0.5 mM (5R)-5-hydroxy-L- lysine) {ECO:0000269 PubMed:22241472}; Vmax=4.95 umol/min/mg enzyme toward (5R)-5-hydroxy-L-lysine (in the presence of 2 mM ATP) {ECO:0000269 PubMed:22241472}; Vmax=0.49 umol/min/mg enzyme toward (5R)-5-hydroxy-L-lysine (in the presence of 0.2 mM GTP) {ECO:0000269 PubMed:22241472}; Vmax=5.28 umol/min/mg enzyme toward ATP (in the presence of 0.5 mM (5R)-5-hydroxy-L-lysine) {ECO:0000269 PubMed:22241472}; Vmax=0.57 umol/min/mg enzyme toward GTP (in the presence of 0.5 mM (5R)-5-hydroxy-L-lysine) {ECO:0000269 PubMed:22241472};
UniProtKB/Swiss-Prot CatalyticActivity:
GTP + 5-hydroxy-L-lysine = GDP + 5-phosphonooxy-L-lysine.
UniProtKB/Swiss-Prot Function:
Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.

Enzyme Numbers (IUBMB) for HYKK Gene

Phenotypes for HYKK Gene

GenomeRNAi human phenotypes for HYKK:
genes like me logo Genes that share phenotypes with HYKK: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HYKK Gene

Localization for HYKK Gene

Subcellular locations from UniProtKB/Swiss-Prot for HYKK Gene

Cytoplasm.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for HYKK Gene

Pathways & Interactions for HYKK Gene

genes like me logo Genes that share pathways with HYKK: view

Interacting Proteins for HYKK Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000373640%0d%0a9606.ENSP00000310978%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000200457%0d%0a
Selected Interacting proteins: ENSP00000373640 for HYKK Gene via STRING

Gene Ontology (GO) - Biological Process for HYKK Gene

None

No data available for SIGNOR curated interactions for HYKK Gene

Drugs & Compounds for HYKK Gene

(2) Drugs for HYKK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for HYKK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5-Hydroxylysine
  • (2S,5R)-2,6-diamino-5-hydroxyhexanoate
  • (2S,5R)-2,6-diamino-5-hydroxyhexanoic acid
  • (2S,5R)-5-hydroxylysine
  • (5R)-5-hydroxy-L-lysine
  • 5-Hydroxy-L-lysine
1190-94-9
5-phosphonooxy-L-lysine
genes like me logo Genes that share compounds with HYKK: view

Transcripts for HYKK Gene

Alternative Splicing Database (ASD) splice patterns (SP) for HYKK Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for HYKK Gene

GeneLoc Exon Structure for
HYKK
ECgene alternative splicing isoforms for
HYKK

Expression for HYKK Gene

mRNA expression in normal human tissues for HYKK Gene

genes like me logo Genes that share expression patterns with HYKK: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HYKK Gene

Orthologs for HYKK Gene

This gene was present in the common ancestor of animals.

Orthologs for HYKK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HYKK 35
  • 89.99 (n)
  • 86.6 (a)
HYKK 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HYKK 35
  • 78.11 (n)
  • 75.34 (a)
HYKK 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hykk 35
  • 84 (n)
  • 79.89 (a)
Hykk 16
Hykk 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia AGPHD1 35
  • 99.37 (n)
  • 99.2 (a)
HYKK 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hykk 35
  • 84.54 (n)
  • 83.11 (a)
oppossum
(Monodelphis domestica)
Mammalia HYKK 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HYKK 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves AGPHD1 35
  • 62.85 (n)
  • 60.76 (a)
AGPHD1 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hykk 35
  • 64.05 (n)
  • 60 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:171550 35
  • 56.13 (n)
  • 48.56 (a)
HYKK (1 of 2) 36
  • 47 (a)
OneToMany
HYKK (2 of 2) 36
  • 43 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004612 35
  • 45.91 (n)
  • 32.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31751 35
  • 45.81 (n)
  • 34.5 (a)
CG31751 36
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
-- 36
  • 28 (a)
OneToMany
-- 36
  • 23 (a)
OneToMany
Species with no ortholog for HYKK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HYKK Gene

ENSEMBL:
Gene Tree for HYKK (if available)
TreeFam:
Gene Tree for HYKK (if available)

Paralogs for HYKK Gene

No data available for Paralogs for HYKK Gene

Variants for HYKK Gene

Sequence variations from dbSNP and Humsavar for HYKK Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs952215 -- 78,526,811(+) AGATA(C/T)GAAGG intron-variant
rs952216 -- 78,526,860(+) ATGAC(C/T)ATGAG intron-variant
rs1504545 -- 78,526,129(+) AGATA(C/G)AGTGG intron-variant
rs1504546 -- 78,531,893(+) AAATA(C/T)GTAGT intron-variant
rs1847530 -- 78,531,689(+) accac(A/G)ctggc intron-variant

Variation tolerance for HYKK Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.91; 67.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HYKK Gene

HapMap Linkage Disequilibrium report
HYKK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HYKK Gene

Disorders for HYKK Gene

Relevant External Links for HYKK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HYKK

No disorders were found for HYKK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HYKK Gene

Publications for HYKK Gene

  1. Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine. (PMID: 22241472) Veiga-da-Cunha M. … Van Schaftingen E. (J. Biol. Chem. 2012) 2 3 4 67
  2. Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. (PMID: 18780872) Liu P. … You M. (J. Natl. Cancer Inst. 2008) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns. (PMID: 25006744) Castaldi P.J. … Silverman E.K. (Am. J. Respir. Crit. Care Med. 2014) 3
  5. Genetic association between AGPHD1 variant and lung cancer risk. (PMID: 25074529) Wang H. … Liu Z.D. (Cell Biochem. Biophys. 2014) 3

Products for HYKK Gene

Sources for HYKK Gene

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