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Aliases for HYKK Gene

Aliases for HYKK Gene

  • Hydroxylysine Kinase 2 3
  • AGPHD1 3 4 6
  • Aminoglycoside Phosphotransferase Domain-Containing Protein 1 3 4
  • Aminoglycoside Phosphotransferase Domain Containing 1 2 3
  • 5-Hydroxy-L-Lysine Kinase 3 4
  • 5-Hydroxylysine Kinase 2 3
  • EC 2.7.1.81 4

External Ids for HYKK Gene

Previous Symbols for HYKK Gene

  • AGPHD1

Summaries for HYKK Gene

GeneCards Summary for HYKK Gene

HYKK (Hydroxylysine Kinase) is a Protein Coding gene. Diseases associated with HYKK include lung cancer. GO annotations related to this gene include hydroxylysine kinase activity.

UniProtKB/Swiss-Prot for HYKK Gene

  • Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HYKK Gene

Genomics for HYKK Gene

Genomic Location for HYKK Gene

Start:
78,507,564 bp from pter
End:
78,537,373 bp from pter
Size:
29,810 bases
Orientation:
Plus strand

Genomic View for HYKK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HYKK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HYKK Gene

No data available for Regulatory Elements for HYKK Gene

Proteins for HYKK Gene

  • Protein details for HYKK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2RU49-HYKK_HUMAN
    Recommended name:
    Hydroxylysine kinase
    Protein Accession:
    A2RU49
    Secondary Accessions:
    • B7ZMA5
    • F8W6X5
    • Q6ZTN0

    Protein attributes for HYKK Gene

    Size:
    373 amino acids
    Molecular mass:
    41933 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HYKK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HYKK Gene

Proteomics data for HYKK Gene at MOPED

Post-translational modifications for HYKK Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys186

Other Protein References for HYKK Gene

No data available for DME Specific Peptides for HYKK Gene

Domains for HYKK Gene

Protein Domains for HYKK Gene

UniProtKB/Swiss-Prot:

HYKK_HUMAN
Family:
  • Belongs to the aminoglycoside phosphotransferase family.:
    • A2RU49
genes like me logo Genes that share domains with HYKK: view

No data available for Gene Families for HYKK Gene

Function for HYKK Gene

Molecular function for HYKK Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=280 uM for (5R)-5-hydroxy-L-lysine (in the presence of 2 mM ATP) {ECO:0000269 PubMed:22241472}; KM=7.6 uM for (5R)-5-hydroxy-L-lysine (in the presence of 0.2 mM GTP) {ECO:0000269 PubMed:22241472}; KM=810 uM for ATP (in the presence of 0.5 mM (5R)-5-hydroxy-L- lysine) {ECO:0000269 PubMed:22241472}; KM=3.5 uM for GTP (in the presence of 0.5 mM (5R)-5-hydroxy-L- lysine) {ECO:0000269 PubMed:22241472}; Vmax=4.95 umol/min/mg enzyme toward (5R)-5-hydroxy-L-lysine (in the presence of 2 mM ATP) {ECO:0000269 PubMed:22241472}; Vmax=0.49 umol/min/mg enzyme toward (5R)-5-hydroxy-L-lysine (in the presence of 0.2 mM GTP) {ECO:0000269 PubMed:22241472}; Vmax=5.28 umol/min/mg enzyme toward ATP (in the presence of 0.5 mM (5R)-5-hydroxy-L-lysine) {ECO:0000269 PubMed:22241472}; Vmax=0.57 umol/min/mg enzyme toward GTP (in the presence of 0.5 mM (5R)-5-hydroxy-L-lysine) {ECO:0000269 PubMed:22241472};
UniProtKB/Swiss-Prot CatalyticActivity: GTP + 5-hydroxy-L-lysine = GDP + 5-phosphonooxy-L-lysine.
UniProtKB/Swiss-Prot Function: Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-lysine.

Enzyme Numbers (IUBMB) for HYKK Gene

Gene Ontology (GO) - Molecular Function for HYKK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016772 transferase activity, transferring phosphorus-containing groups --
GO:0047992 hydroxylysine kinase activity IEA --
genes like me logo Genes that share ontologies with HYKK: view

Phenotypes for HYKK Gene

GenomeRNAi human phenotypes for HYKK:
genes like me logo Genes that share phenotypes with HYKK: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HYKK Gene

Localization for HYKK Gene

Subcellular locations from UniProtKB/Swiss-Prot for HYKK Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for HYKK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HYKK: view

Pathways for HYKK Gene

SuperPathways for HYKK Gene

No Data Available

Interacting Proteins for HYKK Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000373640%0d%0a9606.ENSP00000310978%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000200457%0d%0a
Selected Interacting proteins: ENSP00000373640 for HYKK Gene via STRING

Gene Ontology (GO) - Biological Process for HYKK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with HYKK: view

No data available for Pathways by source for HYKK Gene

Transcripts for HYKK Gene

Alternative Splicing Database (ASD) splice patterns (SP) for HYKK Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for HYKK Gene

GeneLoc Exon Structure for
HYKK
ECgene alternative splicing isoforms for
HYKK

Expression for HYKK Gene

mRNA expression in normal human tissues for HYKK Gene

genes like me logo Genes that share expressions with HYKK: view

Orthologs for HYKK Gene

This gene was present in the common ancestor of animals.

Orthologs for HYKK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AGPHD1 36
  • 99.37 (n)
  • 99.2 (a)
HYKK 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HYKK 36
  • 89.99 (n)
  • 86.6 (a)
HYKK 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HYKK 36
  • 78.11 (n)
  • 75.34 (a)
HYKK 37
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Agphd1 16
Hykk 36
  • 84 (n)
  • 79.89 (a)
Hykk 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HYKK 37
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HYKK 37
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hykk 36
  • 84.54 (n)
  • 83.11 (a)
chicken
(Gallus gallus)
Aves AGPHD1 36
  • 62.85 (n)
  • 60.76 (a)
AGPHD1 37
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hykk 36
  • 64.05 (n)
  • 60 (a)
zebrafish
(Danio rerio)
Actinopterygii HYKK (1 of 2) 37
  • 47 (a)
OneToMany
HYKK (2 of 2) 37
  • 43 (a)
OneToMany
zgc:171550 36
  • 56.13 (n)
  • 48.56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004612 36
  • 45.91 (n)
  • 32.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31751 36
  • 45.81 (n)
  • 34.5 (a)
CG31751 37
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 27 (a)
OneToMany
-- 37
  • 28 (a)
OneToMany
-- 37
  • 23 (a)
OneToMany
Species with no ortholog for HYKK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HYKK Gene

ENSEMBL:
Gene Tree for HYKK (if available)
TreeFam:
Gene Tree for HYKK (if available)

Paralogs for HYKK Gene

No data available for Paralogs for HYKK Gene

Variants for HYKK Gene

Sequence variations from dbSNP and Humsavar for HYKK Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs931794 -- 78,533,838(+) ATCTC(A/G)TGACA downstream-variant-500B, intron-variant
rs952215 -- 78,526,811(+) AGATA(C/T)GAAGG intron-variant
rs952216 -- 78,526,860(+) ATGAC(C/T)ATGAG intron-variant
rs1504545 -- 78,526,129(+) AGATA(C/G)AGTGG intron-variant
rs1504546 -- 78,531,893(+) AAATA(C/T)GTAGT intron-variant

Relevant External Links for HYKK Gene

HapMap Linkage Disequilibrium report
HYKK

No data available for Structural Variations from Database of Genomic Variants (DGV) for HYKK Gene

Disorders for HYKK Gene

(1) MalaCards Diseases for HYKK Gene

Search for HYKK Gene in MalaCards »
genes like me logo Genes that share disorders with HYKK: view

No data available for UniProtKB/Swiss-Prot for HYKK Gene

Publications for HYKK Gene

  1. Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine. (PMID: 22241472) Veiga-da-Cunha M. … Van Schaftingen E. (J. Biol. Chem. 2012) 2 3 4
  2. Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. (PMID: 18780872) Liu P. … You M. (J. Natl. Cancer Inst. 2008) 2 3
  3. A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. (PMID: 19300482) Pillai S.G. … Goldstein D.B. (PLoS Genet. 2009) 3
  4. Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. (PMID: 19654303) Broderick P. … Houlston R.S. (Cancer Res. 2009) 3
  5. Blood-based CHRNA3 single nucleotide polymorphism and outcome in advanced non-small-cell lung cancer patients. (PMID: 19733931) Carcereny E. … Rosell R. (Lung Cancer 2010) 3

Products for HYKK Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate HYKK
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for HYKK
    • Block miRNA regulation of HYKK using miScript Target Protectors

    Sources for HYKK Gene

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