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Aliases for HYI Gene

Aliases for HYI Gene

  • Hydroxypyruvate Isomerase (Putative) 2 3
  • Endothelial Cell Apoptosis Protein E-CE1 3 4
  • Hydroxypyruvate Isomerase Homolog (E. Coli) 2
  • Putative Hydroxypyruvate Isomerase 3
  • Hydroxypyruvate Isomerase Homolog 3
  • EC 5.3.1.22 4
  • HT036 3

External Ids for HYI Gene

Summaries for HYI Gene

Entrez Gene Summary for HYI Gene

  • This gene encodes a putative hydroxypyruvate isomerase, which likely catalyzes the conversion of hydroxypyruvate to 2-hydroxy-3-oxopropanoate, and may be involved in carbohydrate transport and metabolism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for HYI Gene

HYI (Hydroxypyruvate Isomerase (Putative)) is a Protein Coding gene. Diseases associated with HYI include hypertrophic scars. Among its related pathways are Metabolism and Glyoxylate and dicarboxylate metabolism. GO annotations related to this gene include hydroxypyruvate isomerase activity.

UniProtKB/Swiss-Prot for HYI Gene

  • Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HYI Gene

Genomics for HYI Gene

Genomic Location for HYI Gene

Start:
43,450,505 bp from pter
End:
43,454,264 bp from pter
Size:
3,760 bases
Orientation:
Minus strand

Genomic View for HYI Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HYI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HYI Gene

Regulatory Elements for HYI Gene

Proteins for HYI Gene

  • Protein details for HYI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T013-HYI_HUMAN
    Recommended name:
    Putative hydroxypyruvate isomerase
    Protein Accession:
    Q5T013
    Secondary Accessions:
    • D3DPX4
    • D3DPX5
    • Q5Q9A2
    • Q7Z778
    • Q96S83
    • Q9BZR3
    • Q9BZR4

    Protein attributes for HYI Gene

    Size:
    277 amino acids
    Molecular mass:
    30406 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH06140.1; Type=Frameshift; Positions=271; Evidence={ECO:0000305}; Sequence=AAH19041.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAV84474.1; Type=Frameshift; Positions=215, 228, 232, 238; Evidence={ECO:0000305};

    Alternative splice isoforms for HYI Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HYI Gene

Proteomics data for HYI Gene at MOPED

Post-translational modifications for HYI Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HYI Gene

Domains for HYI Gene

Protein Domains for HYI Gene

UniProtKB/Swiss-Prot:

HYI_HUMAN
Family:
  • Belongs to the hyi family.:
    • Q5T013
genes like me logo Genes that share domains with HYI: view

No data available for Gene Families for HYI Gene

Function for HYI Gene

Molecular function for HYI Gene

UniProtKB/Swiss-Prot CatalyticActivity: Hydroxypyruvate = 2-hydroxy-3-oxopropanoate
UniProtKB/Swiss-Prot Function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).
UniProtKB/Swiss-Prot Induction: Up-regulated by exposure to 7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE) after which is found in the culture medium of amniotic epithelial cells.

Enzyme Numbers (IUBMB) for HYI Gene

Gene Ontology (GO) - Molecular Function for HYI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16189514
GO:0008903 hydroxypyruvate isomerase activity IEA --
genes like me logo Genes that share ontologies with HYI: view

Phenotypes for HYI Gene

GenomeRNAi human phenotypes for HYI:
genes like me logo Genes that share phenotypes with HYI: view

miRNA for HYI Gene

miRTarBase miRNAs that target HYI

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for HYI Gene

Localization for HYI Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HYI Gene COMPARTMENTS Subcellular localization image for HYI gene
Compartment Confidence
cytosol 2
nucleus 2
endosome 1
extracellular 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HYI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with HYI: view

Pathways for HYI Gene

genes like me logo Genes that share pathways with HYI: view

Pathways by source for HYI Gene

Gene Ontology (GO) - Biological Process for HYI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with HYI: view

Compounds for HYI Gene

(2) HMDB Compounds for HYI Gene

Compound Synonyms Cas Number PubMed IDs
Hydroxypyruvic acid
  • 3-Hydroxy-2-oxopropanoate
1113-60-6
Tartronate semialdehyde
  • 2-hydroxy-3-oxopropanoate
Not Available
genes like me logo Genes that share compounds with HYI: view

Transcripts for HYI Gene

Unigene Clusters for HYI Gene

Hydroxypyruvate isomerase (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HYI Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
SP1: - - -
SP2: - -
SP3: - -
SP4: - -
SP5: - - -
SP6: - - -
SP7: -
SP8: -

Relevant External Links for HYI Gene

GeneLoc Exon Structure for
HYI
ECgene alternative splicing isoforms for
HYI

Expression for HYI Gene

mRNA expression in normal human tissues for HYI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HYI Gene

SOURCE GeneReport for Unigene cluster for HYI Gene Hs.709864

genes like me logo Genes that share expressions with HYI: view

Orthologs for HYI Gene

This gene was present in the common ancestor of animals.

Orthologs for HYI Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HYI 36
  • 99.28 (n)
  • 99.64 (a)
HYI 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HYI 36
  • 80.63 (n)
  • 81.59 (a)
HYI 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HYI 36
  • 88.81 (n)
  • 90.51 (a)
HYI 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hyi 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HYI 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HYI 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hyi 36
  • 86.28 (n)
  • 87.73 (a)
chicken
(Gallus gallus)
Aves HYI 36
  • 71.89 (n)
  • 73.13 (a)
HYI 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HYI 37
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hyi 36
  • 59.19 (n)
  • 60.84 (a)
zebrafish
(Danio rerio)
Actinopterygii hyi 36
  • 63.04 (n)
  • 62.1 (a)
hyi 37
  • 57 (a)
OneToOne
zgc63850 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003099 36
  • 51.47 (n)
  • 46.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gip 36
  • 46.51 (n)
  • 36.36 (a)
Gip 37
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C05D11.5 36
  • 45.82 (n)
  • 38.65 (a)
C05D11.5 37
  • 36 (a)
OneToOne
Species with no ortholog for HYI:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HYI Gene

ENSEMBL:
Gene Tree for HYI (if available)
TreeFam:
Gene Tree for HYI (if available)

Paralogs for HYI Gene

No data available for Paralogs for HYI Gene

Variants for HYI Gene

Sequence variations from dbSNP and Humsavar for HYI Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1334973 -- 43,455,713(+) CCGAT(G/T)GTCCA upstream-variant-2KB
rs2152114 -- 43,454,961(+) AGCTG(C/G)CCCCA upstream-variant-2KB
rs2782651 -- 43,455,015(+) TCTGT(C/G)TCTGT upstream-variant-2KB
rs2842195 -- 43,455,274(+) ACCCA(G/T)CTCCC upstream-variant-2KB
rs3049336 -- 43,455,975(+) TTTTT(-/TTTTT/TTTTTTT)GCTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HYI Gene

Variant ID Type Subtype PubMed ID
nsv527798 CNV Loss 19592680
nsv438377 CNV Loss 16468122

Relevant External Links for HYI Gene

HapMap Linkage Disequilibrium report
HYI

Disorders for HYI Gene

(1) MalaCards Diseases for HYI Gene

Search for HYI Gene in MalaCards »

Relevant External Links for HYI

Genetic Association Database (GAD)
HYI
genes like me logo Genes that share disorders with HYI: view

No data available for UniProtKB/Swiss-Prot for HYI Gene

Publications for HYI Gene

  1. Biochemical evidence that Escherichia coli hyi (orf b0508, gip) gene encodes hydroxypyruvate isomerase. (PMID: 10561547) Ashiuchi M. … Misono H. (Biochim. Biophys. Acta 1999) 2 3
  2. Low concentration of anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene induces alterations of extracellular protein profile of exposed epithelial cells. (PMID: 19722193) Liu H. … Yu Y. (Proteomics 2009) 4 23
  3. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  4. Expressed sequence tag analysis of adult human iris for the NEIBank project: steroid-response factors and similarities with retinal pigment epithelium. (PMID: 12107412) Wistow G. … Peterson K. (Mol. Vis. 2002) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for HYI Gene

Sources for HYI Gene

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