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HYI Gene

protein-coding   GIFtS: 52
GCID: GC01M043916

Hydroxypyruvate Isomerase (Putative)

(Previous name: hydroxypyruvate isomerase homolog (E. coli))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Hydroxypyruvate Isomerase (Putative)1 2     Hydroxypyruvate Isomerase Homolog2
Endothelial Cell Apoptosis Protein E-CE12 3     Putative Hydroxypyruvate Isomerase2
Hydroxypyruvate Isomerase Homolog (E. Coli)1     EC 5.3.1.223
HT0362     

External Ids:    HGNC: 269481   Entrez Gene: 818882   Ensembl: ENSG000001789227   UniProtKB: Q5T0133   
ORGUL members:         

Export aliases for HYI gene to outside databases

Previous GC identifers: GC01M043586 GC01M043689 GC01M042035


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HYI Gene:
This gene encodes a putative hydroxypyruvate isomerase, which likely catalyzes the conversion of hydroxypyruvate
to 2-hydroxy-3-oxopropanoate, and may be involved in carbohydrate transport and metabolism. Alternatively spliced
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for HYI Gene:
HYI (hydroxypyruvate isomerase (putative)) is a protein-coding gene. Diseases associated with HYI include hypertrophic scars, and endotheliitis. GO annotations related to this gene include hydroxypyruvate isomerase activity.

UniProtKB/Swiss-Prot: HYI_HUMAN, Q5T013
Function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also
termed tartronate semialdehyde) (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the HYI gene promoter:
         AML1a   Egr-1   Olf-1   XBP-1   Tal-1beta   GATA-1   Max   IRF-2   ARP-1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HYI promoter sequence
   Search Chromatin IP Primers for HYI

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HYI


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.2   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p34.2

HYI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HYI gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M043916:  view genomic region     (about GC identifiers)

Start:
43,916,824 bp from pter      End:
43,919,660 bp from pter
Size:
2,837 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HYI_HUMAN, Q5T013 (See protein sequence)
Recommended Name: Putative hydroxypyruvate isomerase  
Size: 277 amino acids; 30406 Da
Sequence caution: Sequence=AAH06140.1; Type=Frameshift; Positions=271; Sequence=AAH19041.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=AAV84474.1; Type=Frameshift; Positions=215, 228,
232, 238;
Secondary accessions: D3DPX4 D3DPX5 Q5Q9A2 Q7Z778 Q96S83 Q9BZR3 Q9BZR4
Alternative splicing: 4 isoforms:  Q5T013-1   Q5T013-2   Q5T013-3   Q5T013-4   

Explore the universe of human proteins at neXtProt for HYI: NX_Q5T013

Explore proteomics data for HYI at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HYI Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001177809.1  NP_001230455.1  NP_112484.3  

    ENSEMBL proteins: 
     ENSP00000361510   ENSP00000361511   ENSP00000428803   ENSP00000428501   ENSP00000361507  
     ENSP00000361509   ENSP00000428399   ENSP00000361502   ENSP00000461969   ENSP00000361503  

    HYI Human Recombinant Protein Products:

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    Novus Biologicals HYI Protein
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    Cloud-Clone Corp. Proteins for HYI

    HYI Antibody Products:

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    LSBio Antibodies in human, mouse, rat for HYI

    HYI Assay Products:

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    Cloud-Clone Corp. CLIAs for HYI


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR026040 HyI-like
     IPR013022 Xyl_isomerase-like_TIM-brl

    Graphical View of Domain Structure for InterPro Entry Q5T013

    ProtoNet protein and cluster: Q5T013

    UniProtKB/Swiss-Prot: HYI_HUMAN, Q5T013
    Similarity: Belongs to the hyi family


    HYI for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HYI_HUMAN, Q5T013
    Function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also
    termed tartronate semialdehyde) (By similarity)
    Catalytic activity: Hydroxypyruvate = 2-hydroxy-3-oxopropanoate
    Induction: Up-regulated by exposure to 7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE) after
    which is found in the culture medium of amniotic epithelial cells

         Enzyme Number (IUBMB): EC 5.3.1.221

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008903hydroxypyruvate isomerase activity IEA--
         
    HYI for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HYI:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HYI
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HYI

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HYI
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HYI

    miRNA
    Products:
        
    miRTarBase miRNAs that target HYI:
    hsa-mir-1 (MIRT023937)

    Block miRNA regulation of human, mouse, rat HYI using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate HYI:
    hsa-miR-1293
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HYI

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HYI

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for HYI 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HYI


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    endosome1
    extracellular1
    golgi apparatus1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HYI About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.38
    2Glyoxylate and dicarboxylate metabolism
    Glyoxylate and dicarboxylate metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for HYI):
        Glyoxylate and dicarboxylate metabolism
    Metabolic pathways


    HYI for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HYI
    Interactions:

        Search GeneGlobe Interaction Network for HYI

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for HYI (Q5T0133 ENSP000003615074) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TEX11Q8IYF33, ENSP000003409954I2D: score=3 STRING: ENSP00000340995
    SIAH1Q8IUQ43I2D: score=5 
    GRHPRENSP000003134324STRING: ENSP00000313432
    ENSG00000227317ENSP000004031544STRING: ENSP00000403154
    GPX7ENSP000003546774STRING: ENSP00000354677
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HYI

    2 HMDB Compounds for HYI    About this table
    CompoundSynonyms CAS #PubMed Ids
    Hydroxypyruvic acid3-Hydroxy-2-oxopropanoate (see all 8)1113-60-6--
    Tartronate semialdehyde2-hydroxy-3-oxopropanoate (see all 2)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HYI gene (3 alternative transcripts): 
    NM_001190880.2  NM_001243526.1  NM_031207.5  

    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483618 ENST00000372433 ENST00000372434 ENST00000470662 ENST00000487366
    ENST00000372430 ENST00000372432 ENST00000372427(uc001cjm.3 uc021omq.1)
    ENST00000486909 ENST00000496142 ENST00000469587 ENST00000372425 ENST00000583037(uc021omp.1 uc001cjo.3 uc001cjn.3)
    ENST00000372426

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HYI using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate HYI:
    hsa-miR-1293
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HYI
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HYI (NM_031207)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HYI
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HYI
    Primer
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    OriGene qPCR primer pairs and template standards for HYI
    OriGene qSTAR qPCR primer pairs in human, mouse for HYI
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HYI
      QuantiTect SYBR Green Assays in human, mouse, rat HYI
      Search QuantiFast Probe-based Assays in human, mouse, rat HYI

    Selected AceView cDNA sequences (see all 120):

    AA757722 BM692932 CN483307 BF872012 BM826556 CA419183 AY037165 AA687643 
    BM701171 BM971494 BX423489 CD672533 BU073145 AF284751 N95780 BX423490 
    CA433653 AW390483 AA464116 AF284750 CD672534 BQ879223 AI028300 BX396306 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HYI (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
    SP1:                          -                             -                                                     -               
    SP2:                          -                             -                                                                     
    SP3:                                                  -                                                           -               
    SP4:                          -                       -                                                                           
    SP5:                                                  -     -                                                     -               


    ECgene alternative splicing isoforms for HYI

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HYI expression in normal human tissues (normalized intensities)      HYI embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCAGGTGGC
    HYI Expression
    About this image


    HYI expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Peripheral blood-derived hematopoietic stem cells (family)
     
     Ovary (Reproductive System)
     
     Adipose (Muscoskeletal System)
    HYI Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HYI Protein Expression
        Custom PCR Arrays for HYI
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HYI gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves HYI1 hydroxypyruvate isomerase (putative) 71.89(n)
    73.13(a)
      424567  NM_001277570.1  NP_001264499.1 
    lizard
    (Anolis carolinensis)
    Reptilia HYI6
    hydroxypyruvate isomerase (putative)
    63(a)
    1 ↔ 1
    4(107442496-107454084)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hyi1 hydroxypyruvate isomerase (putative) 59.19(n)
    60.84(a)
      100135187  NM_001113890.1  NP_001107362.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc638502 hypothetical protein MGC63850 69.57(n)   393305  BC053111.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gip1 GIP-like 46.51(n)
    36.36(a)
      31960  NM_078551.3  NP_511106.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C05D11.51 C05D11.5 45.82(n)
    38.65(a)
      182258  NM_066003.5  NP_498404.1 
            Species with no ortholog for HYI

    ENSEMBL Gene Tree for HYI (if available)
    TreeFam Gene Tree for HYI (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HYI (see all 27)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1459465161,2
    --43920461(+) AAATGC/TTGAGA 3 -- us2k10--------
    rs1397961101,2
    --43920486(+) TTGCCA/GGAAGG 3 -- us2k10--------
    rs1165603481,2
    F--43920500(+) CTGGGC/ATGTAG 3 -- us2k11Minor allele frequency- A:0.03NA 120
    rs21521141,2
    C,F--43920632(+) AGCTGC/GCCCCA 3 -- us2k11Minor allele frequency- G:0.01WA 118
    rs27826511,2
    C,F,A,H--43920686(+) TCTGTG/CTCTGT 3 -- us2k128Minor allele frequency- C:0.38NS EA NA WA CSA 2773
    rs1815396831,2
    C--43920934(+) ACATTA/GGGAAC 3 -- us2k10--------
    rs28421951,2
    C,F,A,H--43920945(+) ACCCAG/TCTCCC 3 -- us2k118Minor allele frequency- T:0.16EA NS NA 3522
    rs1494340851,2
    --43921028(+) CCGTGA/GTGAAC 3 -- us2k10--------
    rs1448130811,2
    --43921128(+) TTGCAG/TCTGGT 3 -- us2k10--------
    rs1856670141,2
    --43921165(+) TGGAAC/TGTGTT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for HYI (43916824 - 43919660 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HYI:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv438377CNV Loss16468122
    nsv527798CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing HYI
    DNA2.0 Custom Variant and Variant Library Synthesis for HYI

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    6 diseases for HYI:    About MalaCards
    hypertrophic scars    endotheliitis    parkinson's disease    retinitis
    malaria    prostatitis


    HYI for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): HYI

    Export disorders for HYI gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HYI gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with HYI)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Biochemical evidence that Escherichia coli hyi (orf b0508, gip) gene encodes hydroxypyruvate isomerase. (PubMed id 10561547)1, 3 Ashiuchi M. and Misono H. (Biochim. Biophys. Acta 1999)
    2. Low concentration of anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene induces alterations of extracellular protein profile of exposed epithelial cells. (PubMed id 19722193)2, 9 Liu H.... Yu Y. (Proteomics 2009)
    3. [Analysis of the binding domain of hydroxypyruvate isomerase homologues in hypertrophic scar fibroblasts]. (PubMed id 22490543)1 Wang J....Zhao Y. (Zhonghua Shao Shang Za Zhi 2012)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data. (PubMed id 17052657)4 Fung H.C....Singleton A. (Lancet Neurol 2006)
    9. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    10. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81888 HGNC: 26948 AceView: HT036 Ensembl:ENSG00000178922 euGenes: HUgn81888
    ECgene: HYI Kegg: 81888 H-InvDB: HYI

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HYI Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HYI Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HYI gene:
    Search GeneIP for patents involving HYI

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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