Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HYI Gene

Aliases for HYI Gene

  • Hydroxypyruvate Isomerase (Putative) 2 3 5
  • Endothelial Cell Apoptosis Protein E-CE1 3 4
  • Hydroxypyruvate Isomerase Homolog (E. Coli) 2
  • Hydroxypyruvate Isomerase Homolog 3
  • EC 4
  • HT036 3

External Ids for HYI Gene

Previous GeneCards Identifiers for HYI Gene

  • GC01M043586
  • GC01M043689
  • GC01M043916
  • GC01M042035

Summaries for HYI Gene

Entrez Gene Summary for HYI Gene

  • This gene encodes a putative hydroxypyruvate isomerase, which likely catalyzes the conversion of hydroxypyruvate to 2-hydroxy-3-oxopropanoate, and may be involved in carbohydrate transport and metabolism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for HYI Gene

HYI (Hydroxypyruvate Isomerase (Putative)) is a Protein Coding gene. Among its related pathways are Glyoxylate and dicarboxylate metabolism and Metabolism. GO annotations related to this gene include hydroxypyruvate isomerase activity.

UniProtKB/Swiss-Prot for HYI Gene

  • Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HYI Gene

Genomics for HYI Gene

Regulatory Elements for HYI Gene

Enhancers for HYI Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HYI on UCSC Golden Path with GeneCards custom track

Promoters for HYI Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HYI on UCSC Golden Path with GeneCards custom track

Genomic Location for HYI Gene

43,450,607 bp from pter
43,455,882 bp from pter
5,276 bases
Minus strand

Genomic View for HYI Gene

Genes around HYI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HYI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HYI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HYI Gene

Proteins for HYI Gene

  • Protein details for HYI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative hydroxypyruvate isomerase
    Protein Accession:
    Secondary Accessions:
    • D3DPX4
    • D3DPX5
    • Q5Q9A2
    • Q7Z778
    • Q96S83
    • Q9BZR3
    • Q9BZR4

    Protein attributes for HYI Gene

    277 amino acids
    Molecular mass:
    30406 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH06140.1; Type=Frameshift; Positions=271; Evidence={ECO:0000305}; Sequence=AAH19041.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAV84474.1; Type=Frameshift; Positions=215, 228, 232, 238; Evidence={ECO:0000305};

    Alternative splice isoforms for HYI Gene


neXtProt entry for HYI Gene

Proteomics data for HYI Gene at MOPED

Post-translational modifications for HYI Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HYI Gene

Domains & Families for HYI Gene

Protein Domains for HYI Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the hyi family.
  • Belongs to the hyi family.
genes like me logo Genes that share domains with HYI: view

No data available for Gene Families for HYI Gene

Function for HYI Gene

Molecular function for HYI Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydroxypyruvate = 2-hydroxy-3-oxopropanoate.
UniProtKB/Swiss-Prot Function:
Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).
UniProtKB/Swiss-Prot Induction:
Up-regulated by exposure to 7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE) after which is found in the culture medium of amniotic epithelial cells.

Enzyme Numbers (IUBMB) for HYI Gene

Gene Ontology (GO) - Molecular Function for HYI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with HYI: view
genes like me logo Genes that share phenotypes with HYI: view

Animal Model Products

miRNA for HYI Gene

miRTarBase miRNAs that target HYI

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HYI Gene

Localization for HYI Gene

Subcellular locations from

Jensen Localization Image for HYI Gene COMPARTMENTS Subcellular localization image for HYI gene
Compartment Confidence
cytosol 3
golgi apparatus 2
nucleus 2
plasma membrane 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HYI Gene

Pathways & Interactions for HYI Gene

genes like me logo Genes that share pathways with HYI: view

Pathways by source for HYI Gene

Gene Ontology (GO) - Biological Process for HYI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with HYI: view

No data available for SIGNOR curated interactions for HYI Gene

Drugs & Compounds for HYI Gene

(1) Drugs for HYI Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydroxypyruvic acid Experimental Pharma 0

(1) Additional Compounds for HYI Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Tartronate semialdehyde
  • 2-Hydroxy-3-oxopropanoate
  • 2-Hydroxy-3-oxopropanoic acid
genes like me logo Genes that share compounds with HYI: view

Transcripts for HYI Gene

Unigene Clusters for HYI Gene

Hydroxypyruvate isomerase (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HYI Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
SP1: - - -
SP2: - -
SP3: - -
SP4: - -
SP5: - - -
SP6: - - -
SP7: -
SP8: -

Relevant External Links for HYI Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HYI Gene

mRNA expression in normal human tissues for HYI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HYI Gene

This gene is overexpressed in Seminal vesicle (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HYI Gene

SOURCE GeneReport for Unigene cluster for HYI Gene Hs.709864

genes like me logo Genes that share expression patterns with HYI: view

Protein tissue co-expression partners for HYI Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HYI Gene

Orthologs for HYI Gene

This gene was present in the common ancestor of animals.

Orthologs for HYI Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HYI 35
  • 80.63 (n)
  • 81.59 (a)
HYI 36
  • 80 (a)
(Canis familiaris)
Mammalia HYI 35
  • 88.81 (n)
  • 90.51 (a)
HYI 36
  • 80 (a)
(Pan troglodytes)
Mammalia HYI 35
  • 99.28 (n)
  • 99.64 (a)
HYI 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Hyi 35
  • 86.28 (n)
  • 87.73 (a)
(Monodelphis domestica)
Mammalia HYI 36
  • 74 (a)
(Mus musculus)
Mammalia Hyi 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia HYI 36
  • 78 (a)
(Gallus gallus)
Aves HYI 35
  • 71.89 (n)
  • 73.13 (a)
HYI 36
  • 61 (a)
(Anolis carolinensis)
Reptilia HYI 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hyi 35
  • 59.19 (n)
  • 60.84 (a)
(Danio rerio)
Actinopterygii hyi 35
  • 63.04 (n)
  • 62.1 (a)
zgc63850 35
hyi 36
  • 57 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003099 35
  • 51.47 (n)
  • 46.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gip 35
  • 46.51 (n)
  • 36.36 (a)
Gip 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea C05D11.5 35
  • 45.82 (n)
  • 38.65 (a)
C05D11.5 36
  • 36 (a)
Species with no ortholog for HYI:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HYI Gene

Gene Tree for HYI (if available)
Gene Tree for HYI (if available)

Paralogs for HYI Gene

No data available for Paralogs for HYI Gene

Variants for HYI Gene

Sequence variations from dbSNP and Humsavar for HYI Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_032611 -
rs1334973 -- 43,455,713(+) CCGAT(G/T)GTCCA upstream-variant-2KB, utr-variant-5-prime
rs2152114 -- 43,454,961(+) AGCTG(C/G)CCCCA upstream-variant-2KB, utr-variant-5-prime
rs2782651 -- 43,455,015(+) TCTGT(C/G)TCTGT upstream-variant-2KB, utr-variant-5-prime
rs3049336 -- 43,455,975(+) TTTTT(-/TTTTT/TTTTTTT)GCTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HYI Gene

Variant ID Type Subtype PubMed ID
nsv527798 CNV Loss 19592680
nsv438377 CNV Loss 16468122

Variation tolerance for HYI Gene

Residual Variation Intolerance Score: 70% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.09; 50.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HYI Gene

Disorders for HYI Gene

Relevant External Links for HYI

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HYI Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HYI Gene

Publications for HYI Gene

  1. Biochemical evidence that Escherichia coli hyi (orf b0508, gip) gene encodes hydroxypyruvate isomerase. (PMID: 10561547) Ashiuchi M. … Misono H. (Biochim. Biophys. Acta 1999) 2 3 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. [Analysis of the binding domain of hydroxypyruvate isomerase homologues in hypertrophic scar fibroblasts]. (PMID: 22490543) Wang J. … Zhao Y. (Zhonghua Shao Shang Za Zhi 2012) 3

Products for HYI Gene

Sources for HYI Gene