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Aliases for HYI Gene

Aliases for HYI Gene

  • Hydroxypyruvate Isomerase (Putative) 2 3 5
  • Endothelial Cell Apoptosis Protein E-CE1 3 4
  • Hydroxypyruvate Isomerase Homolog (E. Coli) 2
  • Putative Hydroxypyruvate Isomerase 3
  • Hydroxypyruvate Isomerase Homolog 3
  • EC 5.3.1.22 4
  • HT036 3

External Ids for HYI Gene

Previous GeneCards Identifiers for HYI Gene

  • GC01M043586
  • GC01M043689
  • GC01M043916
  • GC01M042035

Summaries for HYI Gene

Entrez Gene Summary for HYI Gene

  • This gene encodes a putative hydroxypyruvate isomerase, which likely catalyzes the conversion of hydroxypyruvate to 2-hydroxy-3-oxopropanoate, and may be involved in carbohydrate transport and metabolism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for HYI Gene

HYI (Hydroxypyruvate Isomerase (Putative)) is a Protein Coding gene. Among its related pathways are Metabolism and Glyoxylate and dicarboxylate metabolism. GO annotations related to this gene include hydroxypyruvate isomerase activity.

UniProtKB/Swiss-Prot for HYI Gene

  • Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HYI Gene

Genomics for HYI Gene

Regulatory Elements for HYI Gene

Enhancers for HYI Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G043388 1.4 ENCODE dbSUPER 13.5 +66.2 66158 2.8 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF143 FOS MED8 HYI SZT2 ENSG00000229431
GH01G043357 1.3 ENCODE dbSUPER 12.5 +96.2 96236 4.1 PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 MED8 HYI ENSG00000229431 GC01P043360 CDC20
GH01G043404 1 ENCODE 16.2 +50.5 50473 1.1 ATF1 ARNT TCF12 ZNF766 ELK1 GATA2 ZNF263 NCOA1 MEF2D MBD2 MED8 HYI ENSG00000229431 ELOVL1 LOC105378687 CDC20 SZT2 SZT2-AS1 HYI-AS1 EBNA1BP2
GH01G043452 1 ENCODE 14.2 +1.5 1530 4.5 PKNOX1 AGO1 SIN3A GLI4 ZNF2 YY1 TCF12 GLIS2 GATA2 SP3 MED8 HYI MPL PTPRF SZT2 ENSG00000229431 ST3GAL3 KDM4A-AS1 LOC101929592 HYI-AS1
GH01G043522 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.7 -68.2 -68153 3.4 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 SIN3A YBX1 YY1 ZNF766 MED8 HYI PTPRF GC01M043545
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HYI on UCSC Golden Path with GeneCards custom track

Promoters for HYI Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000005594 1982 1401 PKNOX1 TBL1XR1 AGO1 SIN3A FEZF1 ZNF2 RFX5 YY1 TCF12 GLIS2

Genomic Location for HYI Gene

Chromosome:
1
Start:
43,450,607 bp from pter
End:
43,455,882 bp from pter
Size:
5,276 bases
Orientation:
Minus strand

Genomic View for HYI Gene

Genes around HYI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HYI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HYI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HYI Gene

Proteins for HYI Gene

  • Protein details for HYI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T013-HYI_HUMAN
    Recommended name:
    Putative hydroxypyruvate isomerase
    Protein Accession:
    Q5T013
    Secondary Accessions:
    • D3DPX4
    • D3DPX5
    • Q5Q9A2
    • Q7Z778
    • Q96S83
    • Q9BZR3
    • Q9BZR4

    Protein attributes for HYI Gene

    Size:
    277 amino acids
    Molecular mass:
    30406 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH06140.1; Type=Frameshift; Positions=271; Evidence={ECO:0000305}; Sequence=AAH19041.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAV84474.1; Type=Frameshift; Positions=215, 228, 232, 238; Evidence={ECO:0000305};

    Alternative splice isoforms for HYI Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HYI Gene

Post-translational modifications for HYI Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HYI Gene

Domains & Families for HYI Gene

Protein Domains for HYI Gene

Graphical View of Domain Structure for InterPro Entry

Q5T013

UniProtKB/Swiss-Prot:

HYI_HUMAN :
  • Belongs to the hyi family.
Family:
  • Belongs to the hyi family.
genes like me logo Genes that share domains with HYI: view

No data available for Gene Families for HYI Gene

Function for HYI Gene

Molecular function for HYI Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydroxypyruvate = 2-hydroxy-3-oxopropanoate.
UniProtKB/Swiss-Prot Function:
Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).
UniProtKB/Swiss-Prot Induction:
Up-regulated by exposure to 7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE) after which is found in the culture medium of amniotic epithelial cells.

Enzyme Numbers (IUBMB) for HYI Gene

Gene Ontology (GO) - Molecular Function for HYI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16189514
GO:0008903 hydroxypyruvate isomerase activity IEA --
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with HYI: view
genes like me logo Genes that share phenotypes with HYI: view

Animal Model Products

CRISPR Products

miRNA for HYI Gene

miRTarBase miRNAs that target HYI

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HYI Gene

Localization for HYI Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HYI gene
Compartment Confidence
cytosol 3
plasma membrane 2
nucleus 2
golgi apparatus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for HYI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with HYI: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HYI Gene

Pathways & Interactions for HYI Gene

genes like me logo Genes that share pathways with HYI: view

Pathways by source for HYI Gene

Gene Ontology (GO) - Biological Process for HYI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with HYI: view

No data available for SIGNOR curated interactions for HYI Gene

Drugs & Compounds for HYI Gene

(1) Drugs for HYI Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydroxypyruvic acid Experimental Pharma 0

(1) Additional Compounds for HYI Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Tartronate semialdehyde
  • 2-Hydroxy-3-oxopropanoate
  • 2-Hydroxy-3-oxopropanoic acid
genes like me logo Genes that share compounds with HYI: view

Transcripts for HYI Gene

Unigene Clusters for HYI Gene

Hydroxypyruvate isomerase (putative):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for HYI Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
SP1: - - -
SP2: - -
SP3: - -
SP4: - -
SP5: - - -
SP6: - - -
SP7: -
SP8: -

Relevant External Links for HYI Gene

GeneLoc Exon Structure for
HYI
ECgene alternative splicing isoforms for
HYI

Expression for HYI Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HYI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HYI Gene

This gene is overexpressed in Seminal vesicle (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HYI Gene



Protein tissue co-expression partners for HYI Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HYI Gene:

HYI

SOURCE GeneReport for Unigene cluster for HYI Gene:

Hs.709864

Evidence on tissue expression from TISSUES for HYI Gene

  • Kidney(4.3)
  • Liver(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with HYI: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HYI Gene

Orthologs for HYI Gene

This gene was present in the common ancestor of animals.

Orthologs for HYI Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HYI 34 35
  • 99.28 (n)
dog
(Canis familiaris)
Mammalia HYI 34 35
  • 88.81 (n)
mouse
(Mus musculus)
Mammalia Hyi 35
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hyi 34
  • 86.28 (n)
cow
(Bos Taurus)
Mammalia HYI 34 35
  • 80.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HYI 35
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HYI 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves HYI 34 35
  • 71.89 (n)
lizard
(Anolis carolinensis)
Reptilia HYI 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hyi 34
  • 59.19 (n)
zebrafish
(Danio rerio)
Actinopterygii hyi 34 35
  • 63.04 (n)
zgc63850 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003099 34
  • 51.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta Gip 34 35
  • 46.51 (n)
worm
(Caenorhabditis elegans)
Secernentea C05D11.5 34 35
  • 45.82 (n)
Species where no ortholog for HYI was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HYI Gene

ENSEMBL:
Gene Tree for HYI (if available)
TreeFam:
Gene Tree for HYI (if available)

Paralogs for HYI Gene

No data available for Paralogs for HYI Gene

Variants for HYI Gene

Sequence variations from dbSNP and Humsavar for HYI Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000646282 -- 43,453,963(+) AAAGC(A/G)CCTAC utr-variant-3-prime, utr-variant-5-prime
rs1002605123 -- 43,452,450(+) ATGCC(C/T)AGGTA intron-variant, utr-variant-3-prime
rs1002975255 -- 43,453,446(+) AGGCC(A/G)CCTGT reference, missense, utr-variant-3-prime
rs1003060751 -- 43,455,515(+) TCAAG(A/G)CCTCA upstream-variant-2KB
rs1004344032 -- 43,453,537(+) ACACT(C/T)CCCTG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HYI Gene

Variant ID Type Subtype PubMed ID
nsv438377 CNV loss 16468122
nsv527798 CNV loss 19592680
nsv546128 CNV loss 21841781
nsv950701 CNV deletion 24416366

Variation tolerance for HYI Gene

Residual Variation Intolerance Score: 70% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.09; 50.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HYI Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HYI

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HYI Gene

Disorders for HYI Gene

Relevant External Links for HYI

Genetic Association Database (GAD)
HYI
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HYI

No disorders were found for HYI Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HYI Gene

Publications for HYI Gene

  1. Low concentration of anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene induces alterations of extracellular protein profile of exposed epithelial cells. (PMID: 19722193) Liu H. … Yu Y. (Proteomics 2009) 4 22 64
  2. Biochemical evidence that Escherichia coli hyi (orf b0508, gip) gene encodes hydroxypyruvate isomerase. (PMID: 10561547) Ashiuchi M. … Misono H. (Biochim. Biophys. Acta 1999) 2 3 64
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for HYI Gene

Sources for HYI Gene

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