HYI Gene
protein-coding GIFtS: 51
GCID: GC01M043916
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hydroxypyruvate isomerase (putative)(Previous name: hydroxypyruvate isomerase homolog (E. coli) )
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Aliases
for HYI gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Hydroxypyruvate Isomerase (Putative)1 2 | | Hydroxypyruvate Isomerase Homolog2 | | HT0361 2 | | Putative Hydroxypyruvate Isomerase2 | | Endothelial Cell Apoptosis Protein E-CE12 3 | | EC 5.3.1.223 | | Hydroxypyruvate Isomerase Homolog (E. Coli)1 | | |
Export aliases for HYI gene to outside databasesPrevious GC identifers: GC01M043586 GC01M043689 GC01M042035 |
Summaries
for HYI gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HYI:
This gene encodes a putative hydroxypyruvate isomerase, which likely catalyzes the conversion of hydroxypyruvate to2-hydroxy-3-oxopropanoate, and may be involved in carbohydrate transport and metabolism. Alternatively splicedtranscript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Aug 2011)
UniProtKB/Swiss-Prot: HYI_HUMAN, Q5T013Function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termedtartronate semialdehyde) (By similarity)
|
Genomic Views
for HYI gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HYI gene promoter:
AML1a Egr-1 Olf-1 XBP-1 Tal-1beta GATA-1 Max IRF-2 ARP-1 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for HYI
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HYI |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p34.2 Ensembl cytogenetic band: 1p34.2 HGNC cytogenetic band: 1p34.2HYI Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M043916: view genomic region
(about GC identifiers)
Start:
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43,916,824 bp from pter |
End:
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43,919,660 bp from pter |
Size:
|
2,837 bases |
Orientation:
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minus strand |
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Proteins
for HYI gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HYI_HUMAN, Q5T013 (See
protein sequence)Recommended Name: Putative hydroxypyruvate isomerase Size: 277 amino acids; 30406 Da
Sequence caution: Sequence=AAH06140.1; Type=Frameshift; Positions=271; Sequence=AAH19041.1; Type=Erroneous initiation;Note=Translation N-terminally extended; Sequence=AAV84474.1; Type=Frameshift; Positions=215, 228, 232, 238;
Secondary accessions: D3DPX4 D3DPX5 Q5Q9A2 Q7Z778 Q96S83 Q9BZR3 Q9BZR4Alternative splicing: 4 isoforms: Q5T013-1 Q5T013-2 Q5T013-3 Q5T013-4 Explore the universe of human proteins at neXtProt for HYI: NX_Q5T013
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T013
HYI Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001177809.1 NP_001230455.1 NP_112484.3
ENSEMBL proteins: ENSP00000361510 ENSP00000361511 ENSP00000428803 ENSP00000428501 ENSP00000361507 ENSP00000361509 ENSP00000428399 ENSP00000361502 ENSP00000461969 ENSP00000361503
Human Recombinant Protein Products:
HYI Antibody Products:
Assay Products for HYI: |
Protein
Domains /
Families
for HYI gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HYI for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5T013ProtoNet protein and cluster: Q5T013 UniProtKB/Swiss-Prot: HYI_HUMAN, Q5T013Similarity: Belongs to the hyi family |
Function
for HYI gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HYI_HUMAN, Q5T013Function: Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termedtartronate semialdehyde) (By similarity)Catalytic activity: Hydroxypyruvate = 2-hydroxy-3-oxopropanoateInduction: Up-regulated by exposure to 7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE) after which isfound in the culture medium of amniotic epithelial cellsEnzyme Number (IUBMB): EC 5.3.1.221
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HYI (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HYI (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for HYI | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HYI |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008903 | hydroxypyruvate isomerase activity |
IEA | -- | | GO:0016853 | isomerase activity |
-- | -- |
HYI for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for HYI:
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Pathways & Interactions
for HYI gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Glyoxylate and dicarboxylate metabolism | | | 2 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Kegg Pathways (Kegg details for HYI):
HYI for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HYI
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/14 Interacting proteins for HYI (Q5T0133 ENSP000003615074) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
|
Drugs & Compounds
for HYI gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HYI
2 HMDB Compounds for HYI About this table
Search CenterWatch for drugs/clinical trials and news about HYI
|
Transcripts
for HYI gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HYI gene (3 alternative transcripts): NM_001190880.2 NM_001243526.1 NM_031207.5 Unigene Cluster for HYI: Hydroxypyruvate isomerase (putative) Hs.709864 [show with all ESTs]Unigene Representative Sequence: NM_00124352614 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000483618 ENST00000372433 ENST00000372434 ENST00000470662 ENST00000487366
ENST00000372430 ENST00000372432 ENST00000372427(uc001cjm.3 uc021omq.1)
ENST00000486909 ENST00000496142 ENST00000469587 ENST00000372425 ENST00000583037(uc021omp.1 uc001cjo.3 uc001cjn.3)
ENST00000372426
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HYI (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HYI (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): HYI (NM_031207) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HYI | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HYI |
Additional cDNA sequence: AY037165.1 AY775560.1 BC006140.1 BC019041.2 JF911821.1 13 DOTS entries: DT.95266780 DT.97846077 DT.75101209 DT.100783170 DT.100783171 DT.95266778 DT.100783168 DT.121362275 DT.91731911 DT.100783169 DT.100757113 DT.75111718 DT.92447353 24/120 AceView cDNA sequences (see all 120): CD672533 CN483307 BX423489 BM701171 BM971494 CA419183 BM826556 BF872012 AY037165 AA687643 AA757722 BU073145 BM692932 BM710096 BM715679 BM976864 N95780 AI028300 BX396306 BI822211 BX396305 AW390483 AW869672 AK096244
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for HYI (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b |
|---|
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| SP1: | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for HYI
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Expression
for HYI gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HYI expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCAGGTGGC
About this image
See HYI Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HYI
SOURCE GeneReport for Unigene cluster: Hs.709864
SABiosciences Custom PCR Arrays for HYI
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HYI
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HYI | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HYI | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HYI |
Orthologs
for HYI gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for HYI gene from 6/18 species (see all 18) About this table
Species with no ortholog for HYI
ENSEMBL Gene Tree for HYI (if available)
TreeFam Gene Tree for HYI (if available) |
Paralogs
for HYI gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for HYI gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HYI (43916824 - 43919660 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HYI
1 CNV: 1541 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for HYI gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HYI for disorders About GeneDecksing
2  diseases for HYI: About MalaCardsparkinson's disease retinitis
1 disease from the University of Copenhagen DISEASES database for HYI:Parkinson's disease Export disorders for HYI gene to outside databases
|
Publications
for HYI gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HYI gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with HYI) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Biochemical evidence that Escherichia coli hyi (orf b0508, gip) gene encodes hydroxypyruvate isomerase. (PubMed id 10561547)1, 3 Ashiuchi M. and Misono H. (1999)
- Low concentration of anti-7,8-dihydroxy-9,10-epoxy-7, 8,9,10-tetrahydrobenzo[a]pyrene induces alterations of extracellular protein pr ofile of exposed epithelial cells. (PubMed id 19722193)2, 9 Liu H....Yu Y. (2009)
- [Analysis of the binding domain of hydroxypyruvate iso merase homologues in hypertrophic scar fibroblasts]. (PubMed id 22490543)1 Wang J....Zhao Y. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. (PubMed id 15862967)1 Pope S.N. and Lee I.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for HYI gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HYI gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HYI gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HYI gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for HYI gene:
Search GeneIP for patents involving HYI
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HYI gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for HYI | | OriGene Custom Protein Services for HYI | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HYI | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HYI | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HYI | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HYI | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HYI | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HYI |
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 |  |  |  | |
| | | | Search Tocris compounds for HYI |
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 | | | HYI Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for HYI |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HYI |
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