Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HYI Gene

Aliases for HYI Gene

  • Hydroxypyruvate Isomerase (Putative) 2 3 5
  • Endothelial Cell Apoptosis Protein E-CE1 3 4
  • Hydroxypyruvate Isomerase Homolog (E. Coli) 2
  • Putative Hydroxypyruvate Isomerase 3
  • Hydroxypyruvate Isomerase Homolog 3
  • EC 4
  • HT036 3

External Ids for HYI Gene

Previous GeneCards Identifiers for HYI Gene

  • GC01M043586
  • GC01M043689
  • GC01M043916
  • GC01M042035

Summaries for HYI Gene

Entrez Gene Summary for HYI Gene

  • This gene encodes a putative hydroxypyruvate isomerase, which likely catalyzes the conversion of hydroxypyruvate to 2-hydroxy-3-oxopropanoate, and may be involved in carbohydrate transport and metabolism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for HYI Gene

HYI (Hydroxypyruvate Isomerase (Putative)) is a Protein Coding gene. Among its related pathways are Glyoxylate and dicarboxylate metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include hydroxypyruvate isomerase activity.

UniProtKB/Swiss-Prot for HYI Gene

  • Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).

Additional gene information for HYI Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HYI Gene

Genomics for HYI Gene

GeneHancer (GH) Regulatory Elements for HYI Gene

Promoters and enhancers for HYI Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I043452 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 564.2 +1.5 1530 4.5 PKNOX1 SIN3A GLI4 ZNF2 IRF4 YY1 TCF12 GLIS2 GATA2 RUNX3 HYI HYI-AS1 MED8 DMAP1 MPL PTPRF SZT2 ENSG00000229431 KDM4A-AS1 ST3GAL3
GH01I044212 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 42.8 -757.6 -757600 2.3 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 DMAP1 SZT2 HYI KDM4A-AS1 ARTN LOC101929609 RPS8 HECTD3 PTCH2 KDM4A
GH01I042923 Enhancer 1.5 Ensembl ENCODE dbSUPER 30.1 +531.1 531129 3.9 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 FOXJ3 HYI SZT2 P3H1 RNU6-880P CCDC30 ENSG00000228192 ZNF691 FAM183A KDM4A
GH01I043705 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18.9 -251.7 -251713 3.8 HDGF FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 KDM4A-AS1 ST3GAL3 SZT2 DMAP1 P3H1 KDM4A HYI MED8 ARTN ZNF691
GH01I043388 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.5 +66.2 66158 2.8 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 POLR2B E2F8 MED8 SZT2 HYI CCDC24 CCDC30 HYI-AS1 LOC105378683 ENSG00000229431
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HYI on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HYI gene promoter:

Genomic Locations for HYI Gene

Genomic Locations for HYI Gene
5,276 bases
Minus strand

Genomic View for HYI Gene

Genes around HYI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HYI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HYI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HYI Gene

Proteins for HYI Gene

  • Protein details for HYI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative hydroxypyruvate isomerase
    Protein Accession:
    Secondary Accessions:
    • D3DPX4
    • D3DPX5
    • Q5Q9A2
    • Q7Z778
    • Q96S83
    • Q9BZR3
    • Q9BZR4

    Protein attributes for HYI Gene

    277 amino acids
    Molecular mass:
    30406 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH06140.1; Type=Frameshift; Positions=271; Evidence={ECO:0000305}; Sequence=AAH19041.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAV84474.1; Type=Frameshift; Positions=215, 228, 232, 238; Evidence={ECO:0000305};

    Alternative splice isoforms for HYI Gene


neXtProt entry for HYI Gene

Post-translational modifications for HYI Gene

No Post-translational modifications

No data available for DME Specific Peptides for HYI Gene

Domains & Families for HYI Gene

Gene Families for HYI Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for HYI Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the hyi family.
  • Belongs to the hyi family.
genes like me logo Genes that share domains with HYI: view

Function for HYI Gene

Molecular function for HYI Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydroxypyruvate = 2-hydroxy-3-oxopropanoate.
UniProtKB/Swiss-Prot Function:
Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).
UniProtKB/Swiss-Prot Induction:
Up-regulated by exposure to 7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE) after which is found in the culture medium of amniotic epithelial cells.

Enzyme Numbers (IUBMB) for HYI Gene

Phenotypes From GWAS Catalog for HYI Gene

Gene Ontology (GO) - Molecular Function for HYI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16189514
GO:0008903 hydroxypyruvate isomerase activity IEA --
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with HYI: view
genes like me logo Genes that share phenotypes with HYI: view

miRNA for HYI Gene

miRTarBase miRNAs that target HYI

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HYI Gene

Localization for HYI Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HYI gene
Compartment Confidence
cytosol 3
plasma membrane 2
nucleus 2
golgi apparatus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HYI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with HYI: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HYI Gene

Pathways & Interactions for HYI Gene

genes like me logo Genes that share pathways with HYI: view

Pathways by source for HYI Gene

Gene Ontology (GO) - Biological Process for HYI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with HYI: view

No data available for SIGNOR curated interactions for HYI Gene

Drugs & Compounds for HYI Gene

(1) Drugs for HYI Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hydroxypyruvic acid Experimental Pharma 0

(1) Additional Compounds for HYI Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Tartronate semialdehyde
  • 2-Hydroxy-3-oxopropanoate
  • 2-Hydroxy-3-oxopropanoic acid
genes like me logo Genes that share compounds with HYI: view

Transcripts for HYI Gene

Unigene Clusters for HYI Gene

Hydroxypyruvate isomerase (putative):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HYI Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
SP1: - - -
SP2: - -
SP3: - -
SP4: - -
SP5: - - -
SP6: - - -
SP7: -
SP8: -

Relevant External Links for HYI Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HYI Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HYI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HYI Gene

This gene is overexpressed in Seminal vesicle (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HYI Gene

Protein tissue co-expression partners for HYI Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HYI Gene:


SOURCE GeneReport for Unigene cluster for HYI Gene:


Evidence on tissue expression from TISSUES for HYI Gene

  • Kidney(4.3)
  • Liver(4.3)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with HYI: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HYI Gene

Orthologs for HYI Gene

This gene was present in the common ancestor of animals.

Orthologs for HYI Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HYI 33 34
  • 99.28 (n)
(Canis familiaris)
Mammalia HYI 33 34
  • 88.81 (n)
(Mus musculus)
Mammalia Hyi 34
  • 87 (a)
(Rattus norvegicus)
Mammalia Hyi 33
  • 86.28 (n)
(Bos Taurus)
Mammalia HYI 33 34
  • 80.63 (n)
(Ornithorhynchus anatinus)
Mammalia HYI 34
  • 78 (a)
(Monodelphis domestica)
Mammalia HYI 34
  • 74 (a)
(Gallus gallus)
Aves HYI 33 34
  • 71.89 (n)
(Anolis carolinensis)
Reptilia HYI 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hyi 33
  • 59.19 (n)
(Danio rerio)
Actinopterygii hyi 33 34
  • 63.04 (n)
zgc63850 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003099 33
  • 51.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta Gip 33 34
  • 46.51 (n)
(Caenorhabditis elegans)
Secernentea C05D11.5 33 34
  • 45.82 (n)
Species where no ortholog for HYI was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HYI Gene

Gene Tree for HYI (if available)
Gene Tree for HYI (if available)

Paralogs for HYI Gene

No data available for Paralogs for HYI Gene

Variants for HYI Gene

Sequence variations from dbSNP and Humsavar for HYI Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs111686948 likely-benign, not provided 43,451,930(-) C/G/T intron_variant
rs141158872 likely-benign, not provided 43,453,395(-) C/T coding_sequence_variant, intron_variant, missense_variant
rs62620015 likely-benign, not provided 43,451,268(-) A/C/G 3_prime_UTR_variant, coding_sequence_variant, intron_variant, missense_variant, synonymous_variant
rs1000646282 -- 43,453,963(-) G/A 5_prime_UTR_variant
rs1002605123 -- 43,452,450(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HYI Gene

Variant ID Type Subtype PubMed ID
nsv438377 CNV loss 16468122
nsv527798 CNV loss 19592680
nsv546128 CNV loss 21841781
nsv950701 CNV deletion 24416366

Variation tolerance for HYI Gene

Residual Variation Intolerance Score: 70% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.09; 50.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HYI Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HYI Gene

Disorders for HYI Gene

Additional Disease Information for HYI

No disorders were found for HYI Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HYI Gene

Publications for HYI Gene

  1. Low concentration of anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene induces alterations of extracellular protein profile of exposed epithelial cells. (PMID: 19722193) Liu H … Yu Y (Proteomics 2009) 4 22 58
  2. Biochemical evidence that Escherichia coli hyi (orf b0508, gip) gene encodes hydroxypyruvate isomerase. (PMID: 10561547) Ashiuchi M … Misono H (Biochimica et biophysica acta 1999) 2 3 58
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for HYI Gene

Sources for HYI Gene

Loading form....