Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HYDIN Gene

protein-coding GIFtS: 47
GCID: GC16M070842

HYDIN, axonemal central pair apparatus protein

(Previous names: hydrocephalus inducing, hydrocephalus inducing homolog...)

Explore 2 diseases affiliated with
HYDIN via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
HYDIN, Axonemal Central Pair Apparatus Protein¹ ²		Hydrocephalus Inducing Homolog (Mouse)¹
HYDIN1² ³ ⁵		CILD5²
PPP1R31¹ ²		HYDIN2²
KIAA1864¹ ³		Hydrocephalus-Inducing Protein Homolog²
DKFZp434D0513¹		Protein Phosphatase 1, Regulatory Subunit 31²
Hydrocephalus Inducing¹

External Ids:	HGNC: 19368¹	Entrez Gene: 54768²	Ensembl: ENSG00000157423⁷	OMIM: 610812⁵	UniProtKB: Q4G0P3³

Export aliases for HYDIN gene to outside databases

Previous GC identifers: GC16M070576 GC16M070617 GC16M069576 GC16M069618 GC16M069400

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HYDIN:

This gene encodes a protein that may be involved in cilia motility. Mutations in this gene cause of autosomal recessive

primary ciliary dyskinesia-5, a disorder characterized by the accumulation of cerebrospinal fluid within the

ventricles of the brain. A duplicate copy of this gene has been found in humans on chromosome 1. (provided by RefSeq,

Jan 2013)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HYDIN gene promoter:
CHOP-10 IRF-7A CUTL1 LyF-1 C/EBPalpha GATA-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HYDIN promoter sequence

Search SABiosciences Chromatin IP Primers for HYDIN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HYDIN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.2 Ensembl cytogenetic band: 16q22.2 HGNC cytogenetic band: 16q22.2

HYDIN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HYDIN gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M070842: view genomic region (about GC identifiers)

Start:	70,841,281 bp from pter	End:	71,264,625 bp from pter
Size:	423,345 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HYDIN_HUMAN, Q4G0P3 (See protein sequence)

Recommended Name: Hydrocephalus-inducing protein homolog

Size: 5121 amino acids; 575892 Da

Sequence caution: Sequence=AAH28351.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Sequence=BAB15527.1; Type=Frameshift; Positions=4804;

2 PDB 3D structures from and Proteopedia for HYDIN:

2E6J (3D)

2YS4 (3D)

Secondary accessions: A6NC70 A6NLZ0 B4DRN4 Q8N3H8 Q8N3P6 Q8TC08 Q96JG3 Q96SS4 Q9H5U3 Q9H9B8 Q9NTI0

Q9UBE5

Alternative splicing: 5 isoforms: Q4G0P3-1 Q4G0P3-2 Q4G0P3-5 Q4G0P3-6 Q4G0P3-8 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HYDIN: NX_Q4G0P3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q4G0P3

HYDIN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001185471.1 NP_001185472.1 NP_001257903.1 NP_060028.2

ENSEMBL proteins:

ENSP00000377197 ENSP00000463350 ENSP00000462711 ENSP00000463767 ENSP00000462031

ENSP00000463093 ENSP00000314736 ENSP00000444970 ENSP00000463422 ENSP00000437341

ENSP00000288168 ENSP00000446122 ENSP00000437598 ENSP00000443525 ENSP00000440202

ENSP00000313052 ENSP00000398544 ENSP00000394826 ENSP00000377181

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: HYDIN OriGene Custom Protein Services for HYDIN
	GenScript Custom Purified and Recombinant Proteins Services for HYDIN
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HYDIN

HYDIN Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for HYDIN
	GenScript Custom Superior Antibodies Services for HYDIN
	Search for Antibodies for HYDIN at Abcam
	Uscn Antibodies for HYDIN
	Search ThermoFisher Antibodies for HYDIN

Assay Products for HYDIN:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HYDIN
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HYDIN

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HYDIN for domains About GeneDecksing

1 InterPro domain/family:

IPR008962 PapD-like

Graphical View of Domain Structure for InterPro Entry Q4G0P3

ProtoNet protein and cluster: Q4G0P3

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA Products:		OriGene 3'-UTR Clone (see all 2): HYDIN Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HYDIN
		1 QIAGEN miScript miRNA Assays for microRNA that regulate HYDIN:
		hsa-miR-500a
		SwitchGear 3'UTR luciferase reporter plasmid: HYDIN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HYDIN (see all 4) OriGene shRNA RFP: HYDIN OriGene siRNA: HYDIN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HYDIN

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HYDIN

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HYDIN (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HYDIN OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): HYDIN (NM_001198542)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HYDIN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HYDIN

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HYDIN
		Search LifeMap BioReagents cell lines for HYDIN

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HYDIN

Animal Models:
12 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Hydin):

behavior/neurological	cardiovascular system	craniofacial	growth/size	hematopoietic system
immune system	mortality/aging	muscle	nervous system	reproductive system
respiratory system	skeleton

HYDIN for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HYDIN

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for HYDIN (ENSP00000377197⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP1CA	ENSP00000326031⁴	STRING: ENSP00000326031

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HYDIN
Search CenterWatch for drugs/clinical trials and news about HYDIN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HYDIN gene (5 alternative transcripts):

NM_001198542.1 NM_001198543.1 NM_001270974.1 NM_017558.4 NM_032821.2

Unigene Clusters for HYDIN:

HYDIN, axonemal central pair apparatus protein

Hs.461229 [show with all ESTs], Hs.743479 [show with all ESTs], Hs.744828

Unigene Representative Sequences: BC043273, NM_001270974, JX501991

18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):

ENST00000393567(uc002ezr.3) ENST00000378856(uc010cfy.3) ENST00000542283

ENST00000546257 ENST00000309900 ENST00000543521 ENST00000546297 ENST00000393552

ENST00000538568 ENST00000539447 ENST00000321489(uc021tkq.1) ENST00000538248(uc010vmc.2 uc010vmd.2)

ENST00000545230 ENST00000540892 ENST00000541601 ENST00000288168(uc002ezw.4)

ENST00000542890 ENST00000543639

miRNA Products:		OriGene 3'-UTR Clone (see all 2): HYDIN Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HYDIN
		1 QIAGEN miScript miRNA Assays for microRNA that regulate HYDIN:
		hsa-miR-500a
		SwitchGear 3'UTR luciferase reporter plasmid: HYDIN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HYDIN (see all 4) OriGene shRNA RFP: HYDIN OriGene siRNA: HYDIN
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HYDIN

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HYDIN (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HYDIN OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): HYDIN (NM_001198542)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HYDIN
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HYDIN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HYDIN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HYDIN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HYDIN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HYDIN

Additional cDNA sequence: JX501991.1

13 DOTS entries:

DT.40112854 DT.432774 DT.95069683 DT.95241853 DT.40310687 DT.91656895 DT.95156434 DT.100018487

DT.100663492 DT.120723170 DT.75197703 DT.95320484 DT.97805490

22 AceView cDNA sequences:

AK074472 AL137259 BX106147 BC043273 AI564238 CB851954 CA440183 AI829538

CD358133 BU854299 N50787 BG928962 AI824393 BI560655 AI693696 AW292266

AK026688 AI809964 AI693718 BE935729 BE935732 CB852076

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for HYDIN (see all 9) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	·	3d	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18a	·	18b	^
SP1:																									-						-										-										-
SP2:																									-						-										-
SP3:
SP4:
SP5:

ExUns:	19	^	20a	·	20b	^	21a	·	21b	^	22a	·	22b	·	22c	^	23a	·	23b	^	24	^	25	^	26
SP1:			-												-
SP2:
SP3:															-		-		-		-
SP4:
SP5:

ECgene alternative splicing isoforms for HYDIN

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HYDIN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGACCTTCT

About this image

HYDIN expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Posterior foregut-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HYDIN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HYDIN

SOURCE GeneReport for Unigene clusters: Hs.461229 Hs.743479 Hs.744828

SABiosciences Custom PCR Arrays for HYDIN

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HYDIN Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HYDIN
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HYDIN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HYDIN

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HYDIN

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HYDIN gene from 3/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	--	Uncharacterized protein	12(a)	1 → many	11(1519244-1625761)
zebrafish (Danio rerio)	Actinopterygii	si:ch73-22b10.1⁶	si:ch73-22b10.1	10(a)	1 → many	18(21054460-21182112)
honey bee (Apis mellifera)	Insecta	--	--	5(a)	1 → many	Group9.5(263622-293197)

ENSEMBL Gene Tree for HYDIN (if available)
TreeFam Gene Tree for HYDIN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HYDIN gene

ENSG00000215642² ENSG00000234295²

HYDIN for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for HYDIN
PGOHUM00000244958 PGOHUM00000238085 PGOHUM00000241930

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74861733^1,2	C,	other	70954717(+)	`TCTCCG/ATGCGC`	4	/T /M	mis¹		1		NA	2
rs76335688^1,2	C,	other	70954718(+)	`CTCCGG/TGCGCT`	4	T P	mis¹		1		NA	2
rs114079811^1,2	F,	--	70840841(+)	`GTGTGG/ATGGGG`	2	--	ds500¹		1		WA	118
rs182114562^1,2		--	70840917(+)	`CAGATA/GTGGGA`	2	--	ds500¹		0	--	--	--	--
rs79918991^1,2	C,	--	70840938(+)	`GATGGT/AATAAA`	2	--	ds500¹		1		EA	120
rs148233059^1,2		--	70841030(+)	`TTTATA/GTGAAA`	2	--	ds500¹		0	--	--	--	--
rs141255159^1,2		--	70841060(+)	`CAAAAC/TAGTCA`	2	--	ds500¹		0	--	--	--	--
rs186810540^1,2		--	70841071(+)	`TGTCTA/GAGGGC`	2	--	ds500¹		0	--	--	--	--
rs189989205^1,2		--	70841121(+)	`CCCAGC/TGTCAC`	2	--	ds500¹		0	--	--	--	--
rs181205257^1,2		--	70841196(+)	`GGGAAG/TTATTA`	2	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HYDIN (70841281 - 71091281 bp, first 250kb of HYDIN)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 30 variations for HYDIN
     15/21 CNVs (see all 21): 35401 9762 0678 5835 2043 5836 67027 102324 67026 102323 5834 4010 3124 43930 23514
     8 Indels: 61536 77403 60214 60216 40149 45461 60215 60217
     1 Inversion: 59737
Human Gene Mutation Database (HGMD): HYDIN

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HYDIN

DNA2.0 Custom Variant and Variant Library Synthesis for HYDIN

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HYDIN for disorders About GeneDecksing

OMIM gene information: 610812 OMIM disorders: --

UniProtKB/Swiss-Prot: HYDIN_HUMAN, Q4G0P3

Defects in HYDIN are the cause of primary ciliary dyskinesia 5 (CILD5) [MIM:608647]. An autosomal recessive

form of primary dyskinesia, a disorder characterized by abnormalities of motile cilia. Respiratory infections leading

to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility

is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of

left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary

dyskinesia associated with situs inversus is referred to as Kartagener syndrome. CILD5 is characterized by early onset

of a progressive decline in lung function due to an inability to clear mucus and particles from the airways. Affected

individuals have recurrent infections of the sinuses, ears, airways, and lungs. Sperm motility is also decreased.

Individuals with CILD5 do not have situs inversus

2 diseases for HYDIN: About MalaCards

hydrocephalus oculocerebrorenal syndrome

2 diseases from the University of Copenhagen DISEASES database for HYDIN:

Hydrocephalus Oculocerebrorenal syndrome

1 Novoseek disease relationship for HYDIN gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hydrocephalus	68.3	5	17296793 (1), 16443634 (1), 17394468 (1), 17683645 (1)

Human Genome Epidemiology (HuGE) Navigator: HYDIN (1 document)

Export disorders for HYDIN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HYDIN gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with HYDIN)

Utopia: connect your pdf to the dynamic
world of online information

A 360-kb interchromosomal duplication of the human HYDIN locus. (PubMed id 16938426)^{1, 2, 9} Doggett N.A.... Han C. (2006)
Recessive HYDIN mutations cause primary ciliary dyskinesia without randomization of left-right body asymmetry. (PubMed id 23022101)^{1, 2} Olbrich H....Omran H. (2012)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Congenital hydrocephalus in hy3 mice is caused by a frameshift mutation in Hydin, a large novel gene. (PubMed id 12719380)^{1, 3} Davy B.E. and Robinson M.L. (2003)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Loci for primary ciliary dyskinesia map to chromosome 16p12.1-12.2 and 15q13.1-15.1 in Faroe Islands and Israeli Druze genetic isolates. (PubMed id 14985390)¹ Jeganathan D....Mitchison H.M. (2004)
The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)² Martin J.... Pennacchio L.A. (2004)
Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)¹ Suzuki Y.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 54768	HGNC: 19368	AceView: HYDIN.1	Ensembl:ENSG00000157423	euGenes: HUgn54768
ECgene: HYDIN	H-InvDB: HYDIN

(According to HUGE)
About This Section

HUGE: KIAA1864

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HYDIN	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HYDIN	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for HYDIN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for HYDIN gene:
Search GeneIP for patents involving HYDIN

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for HYDIN
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HYDIN		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HYDIN
	OriGene Protein Over-expression Lysate for HYDIN		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for HYDIN		OriGene 3'-UTR Clone for HYDIN
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HYDIN		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HYDIN
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for HYDIN		OriGene Custom Protein Services for HYDIN
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HYDIN
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HYDIN
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HYDIN
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HYDIN
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HYDIN
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HYDIN

	GenScript Custom Purified and Recombinant Proteins Services for HYDIN		GenScript cDNA clones with any tag delivered in your preferred vector for HYDIN
	GenScript Custom Assay Services for HYDIN		GenScript Custom Superior Antibodies Services for HYDIN
	GenScript Custom overexpressing Cell Line Services for HYDIN		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in HYDIN promoter
	Search Chromatin IP Primers for HYDIN
	RT² qPCR Primer Assay in human, mouse, rat HYDIN
	Search GNC Networks for HYDIN
	SABiosciences Custom PCR Arrays for HYDIN

Search Tocris compounds for HYDIN

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Biologicals
	Novus Tissue Slides

	Search for Antibodies for HYDIN at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for HYDIN
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

HYDIN Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for HYDIN

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HYDIN

	SwitchGear 3'UTR luciferase reporter plasmids for HYDIN
	SwitchGear Promoter luciferase reporter plasmids for HYDIN

Search ThermoFisher Antibodies for HYDIN

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HYDIN

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes HYDIN gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

HYDIN Gene

HYDIN, axonemal central pair apparatus protein

Aliases
for HYDIN gene

Summaries
for HYDIN gene

Genomic Views
for HYDIN gene

Proteins
for HYDIN gene

Protein Domains /
Families
for HYDIN gene

Function
for HYDIN gene

Pathways & Interactions
for HYDIN gene

Drugs & Compounds
for HYDIN gene

Transcripts
for HYDIN gene

Expression
for HYDIN gene

Orthologs
for HYDIN gene

Paralogs
for HYDIN gene

Genomic Variants
for HYDIN gene

Disorders / Diseases
for HYDIN gene

Publications
for HYDIN gene

External Searches for HYDIN gene

Genome Databases showing HYDIN gene

Other Databases showing HYDIN gene

Specialized Databases showing HYDIN gene

Intellectual Property
for HYDIN gene

Products
for HYDIN gene

View Random Gene

Advanced Search

Export list of displayed genes

HYDIN Gene

HYDIN, axonemal central pair apparatus protein

Aliasesfor HYDIN gene

Summariesfor HYDIN gene

Genomic Viewsfor HYDIN gene

Proteinsfor HYDIN gene

Protein Domains /Familiesfor HYDIN gene

Functionfor HYDIN gene

Pathways & Interactionsfor HYDIN gene

Drugs & Compoundsfor HYDIN gene

Transcriptsfor HYDIN gene

Expression for HYDIN gene

Orthologsfor HYDIN gene

Paralogsfor HYDIN gene

Genomic Variantsfor HYDIN gene

Disorders / Diseasesfor HYDIN gene

Publicationsfor HYDIN gene

External Searches for HYDIN gene

Genome Databases showing HYDIN gene

Other Databases showing HYDIN gene

Specialized Databases showing HYDIN gene

Intellectual Propertyfor HYDIN gene

Productsfor HYDIN gene

View Random Gene

Aliases
for HYDIN gene

Summaries
for HYDIN gene

Genomic Views
for HYDIN gene

Proteins
for HYDIN gene

Protein Domains /
Families
for HYDIN gene

Function
for HYDIN gene

Pathways & Interactions
for HYDIN gene

Drugs & Compounds
for HYDIN gene

Transcripts
for HYDIN gene

Expression
for HYDIN gene

Orthologs
for HYDIN gene

Paralogs
for HYDIN gene

Genomic Variants
for HYDIN gene

Disorders / Diseases
for HYDIN gene

Publications
for HYDIN gene

Intellectual Property
for HYDIN gene

Products
for HYDIN gene