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Aliases for HYAL4 Gene

Aliases for HYAL4 Gene

  • Hyaluronoglucosaminidase 4 2 3 5
  • Chondroitin Sulfate Endo-Beta-N-Acetylgalactosaminidase 3 4
  • Chondroitin Sulfate Hydrolase 3 4
  • Hyaluronoglucosaminidase-4 3 4
  • Hyaluronidase 4 2 3
  • EC 4 63
  • Hyal-4 3 4
  • CSHY 3 4
  • EC 3.2.1 63

External Ids for HYAL4 Gene

Previous GeneCards Identifiers for HYAL4 Gene

  • GC07P121963
  • GC07P123025
  • GC07P123039
  • GC07P123014
  • GC07P123079
  • GC07P123272
  • GC07P123469
  • GC07P117848

Summaries for HYAL4 Gene

Entrez Gene Summary for HYAL4 Gene

  • This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for HYAL4 Gene

HYAL4 (Hyaluronoglucosaminidase 4) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan degradation and Articular Cartilage Extracellular Matrix Pathway. GO annotations related to this gene include hyalurononglucosaminidase activity. An important paralog of this gene is HYAL3.

UniProtKB/Swiss-Prot for HYAL4 Gene

  • Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HYAL4 Gene

Genomics for HYAL4 Gene

Regulatory Elements for HYAL4 Gene

Enhancers for HYAL4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HYAL4 on UCSC Golden Path with GeneCards custom track

Genomic Location for HYAL4 Gene

123,828,983 bp from pter
123,877,481 bp from pter
48,499 bases
Plus strand

Genomic View for HYAL4 Gene

Genes around HYAL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HYAL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HYAL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HYAL4 Gene

Proteins for HYAL4 Gene

  • Protein details for HYAL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D0VXG1
    • Q9UL99
    • Q9Y6T9

    Protein attributes for HYAL4 Gene

    481 amino acids
    Molecular mass:
    54249 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HYAL4 Gene

Proteomics data for HYAL4 Gene at MOPED

Selected DME Specific Peptides for HYAL4 Gene

Post-translational modifications for HYAL4 Gene

  • Glycosylation at Asn 86, Asn 115, Asn 177, and Asn 343
  • Modification sites at PhosphoSitePlus

Other Protein References for HYAL4 Gene

Domains & Families for HYAL4 Gene

Suggested Antigen Peptide Sequences for HYAL4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 56 family.
  • Belongs to the glycosyl hydrolase 56 family.
genes like me logo Genes that share domains with HYAL4: view

No data available for Gene Families for HYAL4 Gene

Function for HYAL4 Gene

Molecular function for HYAL4 Gene

GENATLAS Biochemistry:
hyaluroglucosaminidase 4,differentially expressed in placenta and skeletal muscle,involved inglycosaminoglycan catabolism,clustered with HYAL1P1 and SPAM1
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 4.5-5 (for chondroitin sulfate hydrolase activity). {ECO:0000269 PubMed:19889881}; Temperature dependence: Optimum temperature is 37 degrees Celsius. {ECO:0000269 PubMed:19889881};
UniProtKB/Swiss-Prot CatalyticActivity:
Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
UniProtKB/Swiss-Prot Function:
Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide.

Enzyme Numbers (IUBMB) for HYAL4 Gene

genes like me logo Genes that share phenotypes with HYAL4: view

Animal Models for HYAL4 Gene

MGI Knock Outs for HYAL4:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HYAL4 Gene

Localization for HYAL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HYAL4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for HYAL4 Gene COMPARTMENTS Subcellular localization image for HYAL4 gene
Compartment Confidence
peroxisome 2
cytosol 1
extracellular 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for HYAL4 Gene

Pathways & Interactions for HYAL4 Gene

genes like me logo Genes that share pathways with HYAL4: view

Pathways by source for HYAL4 Gene

2 KEGG pathways for HYAL4 Gene
1 R&D Systems pathway for HYAL4 Gene

Interacting Proteins for HYAL4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000223026 for HYAL4 Gene via STRING

Gene Ontology (GO) - Biological Process for HYAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
genes like me logo Genes that share ontologies with HYAL4: view

No data available for SIGNOR curated interactions for HYAL4 Gene

Drugs & Compounds for HYAL4 Gene

(2) Additional Compounds for HYAL4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N-Acetylgalactosamine 4-sulphate
  • 2-(Acetylamino)-2-deoxy-D-Galactose 4-(hydrogen sulfate)
  • 2-(Acetylamino)-2-deoxy-D-Galactose 4-(hydrogen sulphate)
  • GalNAc4S
  • N-Acetyl-D-galactosamine 4-sulfate
  • N-Acetyl-D-galactosamine 4-sulphate
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with HYAL4: view

Transcripts for HYAL4 Gene

mRNA/cDNA for HYAL4 Gene

Unigene Clusters for HYAL4 Gene

Hyaluronoglucosaminidase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HYAL4 Gene

No ASD Table

Relevant External Links for HYAL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HYAL4 Gene

mRNA expression in normal human tissues for HYAL4 Gene

mRNA differential expression in normal tissues according to GTEx for HYAL4 Gene

This gene is overexpressed in Muscle - Skeletal (x20.7), Testis (x9.5), and Skin - Sun Exposed (Lower leg) (x4.0).

Protein differential expression in normal tissues from HIPED for HYAL4 Gene

This gene is overexpressed in Cerebrospinal fluid (45.8), Breast (13.1), and Pancreas (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HYAL4 Gene

SOURCE GeneReport for Unigene cluster for HYAL4 Gene Hs.28673

mRNA Expression by UniProt/SwissProt for HYAL4 Gene

Tissue specificity: Detected in placenta and skeletal muscle.
genes like me logo Genes that share expression patterns with HYAL4: view

Protein tissue co-expression partners for HYAL4 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for HYAL4 Gene

Orthologs for HYAL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HYAL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HYAL4 35
  • 87.36 (n)
  • 86.25 (a)
HYAL4 36
  • 86 (a)
(Canis familiaris)
Mammalia HYAL4 35
  • 89.37 (n)
  • 88.54 (a)
HYAL4 36
  • 88 (a)
(Mus musculus)
Mammalia Hyal4 35
  • 84.34 (n)
  • 79.63 (a)
Hyal4 16
Hyal4 36
  • 80 (a)
(Pan troglodytes)
Mammalia HYAL4 35
  • 99.1 (n)
  • 98.54 (a)
HYAL4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Hyal4 35
  • 82.81 (n)
  • 78.17 (a)
(Monodelphis domestica)
Mammalia HYAL4 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia HYAL4 36
  • 69 (a)
(Gallus gallus)
Aves -- 36
  • 45 (a)
(Anolis carolinensis)
Reptilia HYAL4 36
  • 72 (a)
(Danio rerio)
Actinopterygii LOC100149853 35
  • 59.22 (n)
  • 59.07 (a)
hyal4 36
  • 52 (a)
(Caenorhabditis elegans)
Secernentea T22C8.2 37
  • 30 (a)
chhy-1 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for HYAL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HYAL4 Gene

Gene Tree for HYAL4 (if available)
Gene Tree for HYAL4 (if available)

Paralogs for HYAL4 Gene

Paralogs for HYAL4 Gene

(5) SIMAP similar genes for HYAL4 Gene using alignment to 4 proteins: Pseudogenes for HYAL4 Gene

genes like me logo Genes that share paralogs with HYAL4: view

Variants for HYAL4 Gene

Sequence variations from dbSNP and Humsavar for HYAL4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs6949082 - 123,874,842(+) TAACT(G/T)CATCC intron-variant, nc-transcript-variant, reference, missense
rs766484 -- 123,850,241(+) ACTTA(A/G)Atttt intron-variant
rs1034955 -- 123,868,255(+) ATAAC(A/G)TAACA nc-transcript-variant, utr-variant-5-prime
rs12672205 -- 123,868,274(+) TTACC(A/G)TGAAA nc-transcript-variant, reference, missense
rs12673151 -- 123,857,772(+) AACAT(A/G)TACTA intron-variant

Variation tolerance for HYAL4 Gene

Residual Variation Intolerance Score: 84.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.81; 79.17% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for HYAL4 Gene

Disorders for HYAL4 Gene

Relevant External Links for HYAL4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HYAL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HYAL4 Gene

Publications for HYAL4 Gene

  1. Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31. (PMID: 10493834) Csoka A.B. … Stern R. (Genomics 1999) 2 3 4 67
  2. Identification of human hyaluronidase-4 as a novel chondroitin sulfate hydrolase that preferentially cleaves the galactosaminidic linkage in the trisulfated tetrasaccharide sequence. (PMID: 19889881) Kaneiwa T. … Yamada S. (Glycobiology 2010) 3 23
  3. Human hyaluronidases: electrophoretic multiple forms in somatic tissues and body fluids. Evidence for conserved hyaluronidase potential N-glycosylation sites in different mammalian species. (PMID: 10989127) Fiszer-Szafarz B. … Zou L. (J. Biochem. Biophys. Methods 2000) 3 23
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Identification of amino acid residues required for the substrate specificity of human and mouse chondroitin sulfate hydrolase (conventional hyaluronidase-4). (PMID: 23086929) Kaneiwa T. … Yamada S. (J. Biol. Chem. 2012) 3

Products for HYAL4 Gene

Sources for HYAL4 Gene