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HYAL4 Gene

protein-coding   GIFtS: 54
GCID: GC07P123469

Hyaluronoglucosaminidase 4

  See HYAL4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hyaluronoglucosaminidase 41 2     hyal-42
Hyaluronidase 41 2     hyaluronidase-42
Chondroitin Sulfate Endo-Beta-N-Acetylgalactosaminidase2 3     hyaluronoglucosaminidase-42
Chondroitin Sulfate Hydrolase2 3     Hyal-43
CSHY2 3     Hyaluronoglucosaminidase-43
EC 3.2.1.353 8     EC 3.2.18

External Ids:    HGNC: 53231   Entrez Gene: 235532   Ensembl: ENSG000001063027   OMIM: 6045105   UniProtKB: Q2M3T93   

Export aliases for HYAL4 gene to outside databases

Previous GC identifers: GC07P121963 GC07P123025 GC07P123039 GC07P123014 GC07P123079 GC07P123272 GC07P117848


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HYAL4 Gene:
This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly
degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be
involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to
have hyaluronidase activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for HYAL4 Gene:
HYAL4 (hyaluronoglucosaminidase 4) is a protein-coding gene. Diseases associated with HYAL4 include oxyphilic adenoma. GO annotations related to this gene include hyalurononglucosaminidase activity. An important paralog of this gene is SPAM1.

UniProtKB/Swiss-Prot: HYAL4_HUMAN, Q2M3T9
Function: Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin
sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a
trisulfated tetrasaccharide




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HYAL4 gene promoter:
         AhR   Arnt   MEF-2A   POU2F1   FOXO4   POU2F1b   POU2F1a   POU2F1c   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHYAL4 promoter sequence
   Search Chromatin IP Primers for HYAL4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HYAL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.3   Ensembl cytogenetic band:  7q31.32   HGNC cytogenetic band: 7q31.3

HYAL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HYAL4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P123469:  view genomic region     (about GC identifiers)

Start:
123,469,037 bp from pter      End:
123,517,532 bp from pter
Size:
48,496 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 122,873,836-122,906,152     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HYAL4_HUMAN, Q2M3T9 (See protein sequence)
Recommended Name: Hyaluronidase-4  
Size: 481 amino acids; 54249 Da
Secondary accessions: D0VXG1 Q9UL99 Q9Y6T9

Explore the universe of human proteins at neXtProt for HYAL4: NX_Q2M3T9

Explore proteomics data for HYAL4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn86, Asn115, Asn177, Asn343
  • 2 DME Specific Peptides for HYAL4 (Q2M3T9)
     NWNSKDV  GLAVIDWE 


    See HYAL4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036401.2  
    ENSEMBL proteins: 
     ENSP00000419522   ENSP00000417872   ENSP00000223026   ENSP00000417186   ENSP00000420264  

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    antibodies-online proteins for HYAL4 (2 products) 

     
    antibodies-online peptides for HYAL4

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    antibodies-online antibodies for HYAL4 (10 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR013785 Aldolase_TIM
     IPR018155 Hyaluronidase
     IPR000742 EG-like_dom
     IPR017853 Glycoside_hydrolase_SF

    Graphical View of Domain Structure for InterPro Entry Q2M3T9

    ProtoNet protein and cluster: Q2M3T9

    1 Blocks protein domain: IPB001968 Glycosyl hydrolase family 56 signature

    UniProtKB/Swiss-Prot: HYAL4_HUMAN, Q2M3T9
    Similarity: Belongs to the glycosyl hydrolase 56 family


    Find genes that share domains with HYAL4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HYAL4_HUMAN, Q2M3T9
    Function: Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin
    sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a
    trisulfated tetrasaccharide
    Catalytic activity: Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate
    residues in hyaluronate
    Biophysicochemical properties: pH dependence: Optimum pH is 4.5-5 (for chondroitin sulfate hydrolase activity);
    Temperature dependence: Optimum temperature is 37 degrees Celsius;

         Genatlas biochemistry entry for HYAL4:
    hyaluroglucosaminidase 4,differentially expressed in placenta and skeletal muscle,involved inglycosaminoglycan
    catabolism,clustered with HYAL1P1 and SPAM1

         Enzyme Numbers (IUBMB): EC 3.2.1.351 2 EC 3.2.12

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004415hyalurononglucosaminidase activity IEA--
         
    Find genes that share ontologies with HYAL4           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for HYAL4:
     Decreased Hepatitis C virus re  Decreased Wnt reporter activit  Decreased number of cells in m  Decreased viability with pacli 
     Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HYAL4

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HYAL4_HUMAN, Q2M3T9: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome2
    cytoskeleton1
    cytosol1
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009986cell surface IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with HYAL4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HYAL4 About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.38
    2Glycosaminoglycan degradation
    Glycosaminoglycan degradation
    3Articular Cartilage Extracellular Matrix
    Articular Cartilage Extracellular Matrix


    Find genes that share SuperPaths with HYAL4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for HYAL4
        Articular Cartilage Extracellular Matrix



    2 Kegg Pathways  (Kegg details for HYAL4):
        Glycosaminoglycan degradation
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HYAL4
    Interactions:

        Search GeneGlobe Interaction Network for HYAL4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for HYAL4 (ENSP000002230264) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARSBENSP000002649144STRING: ENSP00000264914
    IDUAENSP000002479334STRING: ENSP00000247933
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process IEA--
    GO:0006027glycosaminoglycan catabolic process TAS10493834
    GO:0030207chondroitin sulfate catabolic process IEA--

    Find genes that share ontologies with HYAL4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HYAL4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HYAL4 gene: 
    NM_012269.2  

    Unigene Cluster for HYAL4:

    Hyaluronoglucosaminidase 4
    Hs.28673  [show with all ESTs]
    Unigene Representative Sequence: AF009010
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489978 ENST00000488323 ENST00000223026(uc003vlc.3 uc011knz.2)
    ENST00000476325 ENST00000483878
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate HYAL4:
    hsa-miR-204 hsa-miR-211 hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidHYAL4 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat HYAL4
      QuantiFast Probe-based Assays in human, mouse, rat HYAL4

    Additional mRNA sequence: 

    AB470346.1 AF009010.1 BC104788.1 BC104790.1 BC143654.1 

    2 DOTS entries:

    DT.310081  DT.121111654 

    14 AceView cDNA sequences:

    AI990387 AA252101 AI033437 R66097 BX117836 AA252069 AI381685 NM_012269 
    AF009010 AA252100 W92155 BG013757 W92156 R67698 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HYAL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTTAACTG
    HYAL4 Expression
    About this image

    HYAL4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HYAL4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.28673

    UniProtKB/Swiss-Prot: HYAL4_HUMAN, Q2M3T9
    Tissue specificity: Detected in placenta and skeletal muscle

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HYAL4 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hyal41 , 5 hyaluronoglucosaminidase 41, 5 84.34(n)1
    79.63(a)1
      6 (11.28 cM)5
    770421  NM_029848.11  NP_084124.11 
     247483295 
    chicken
    (Gallus gallus)
    Aves --
    Hyaluronidase
    45(a)
    many ↔ many
    1(21930620-21945482)
    lizard
    (Anolis carolinensis)
    Reptilia HYAL46
    hyaluronoglucosaminidase 4
    72(a)
    1 ↔ 1
    5(67267939-67281882)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001498531 hyaluronidase-4-like 59.22(n)
    59.07(a)
      100149853  XM_001922088.3  XP_001922123.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T22C8.23 hyaluronidase 30(a)   II(8614552-8617147)   --


    ENSEMBL Gene Tree for HYAL4 (if available)
    TreeFam Gene Tree for HYAL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HYAL4 gene
    SPAM12  HYAL32  HYAL22  HYAL12  
    5 SIMAP similar genes for HYAL4 using alignment to 4 protein entries:     HYAL4_HUMAN (see all proteins):
    HYAL2    LOC402588    SPAM1    HYAL1    HYAL3

    Find genes that share paralogs with HYAL4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for HYAL4
    PGOHUM00000233547


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HYAL4 (see all 639)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1865584801,2
    --123483497(+) CCTTCA/CTTTCA 1 -- us2k10--------
    rs1917643961,2
    --123483515(+) TGAATA/CTGACA 1 -- us2k10--------
    rs1835379721,2
    C--123483533(+) GTCTTC/GGGGTT 1 -- us2k10--------
    rs1881509981,2
    --123483589(+) TTGAAA/TGTTGG 1 -- us2k10--------
    rs1927341481,2
    --123483637(+) ATCCCA/GAAGAC 1 -- us2k10--------
    rs1448270521,2
    C--123483650(+) TTTTCC/TAACTT 1 -- us2k10--------
    rs1820671111,2
    --123483690(+) TACCAA/GTCAAA 1 -- us2k10--------
    rs1485941681,2
    --123483702(+) ATACAC/TTTGGT 1 -- us2k10--------
    rs1866686261,2
    --123483730(+) TATTTC/TTTGGA 1 -- us2k10--------
    rs1914701941,2
    --123484055(+) TGTCAA/GCTCAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HYAL4 (123469037 - 123517532 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HYAL4: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HYAL4
    DNA2.0 Custom Variant and Variant Library Synthesis for HYAL4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604510    OMIM disorders: --

    1 disease for HYAL4:    
    About MalaCards
    oxyphilic adenoma

    1 disease from the University of Copenhagen DISEASES database for HYAL4:
    Oxyphilic adenoma

    Find genes that share disorders with HYAL4           About GenesLikeMe

    Genetic Association Database (GAD): HYAL4
    Human Genome Epidemiology (HuGE) Navigator: HYAL4 (1 document)

    Export disorders for HYAL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HYAL4 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with HYAL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31. (PubMed id 10493834)1, 2, 3 Csoka A.B.... Stern R. (Genomics 1999)
    2. Identification of human hyaluronidase-4 as a novel chondroitin sulfate hydrolase that preferentially cleaves the galactosaminidic linkage in the trisulfated tetrasaccharide sequence. (PubMed id 19889881)1, 2, 9 Kaneiwa T.... Yamada S. (Glycobiology 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Human hyaluronidases: electrophoretic multiple forms in somatic tissues and body fluids. Evidence for conserved hyaluronidase potential N-glycosylation sites in different mammalian species. (PubMed id 10989127)1, 9 Fiszer-Szafarz B....Zou L. (J. Biochem. Biophys. Methods 2000)
    5. Identification of amino acid residues required for the substrate specificity of human and mouse chondroitin sulfate hydrolase (conventional hyaluronidase-4). (PubMed id 23086929)1 Kaneiwa T....Yamada S. (J. Biol. Chem. 2012)
    6. A strategy for precise and large scale identification of core fucosylated glycoproteins. (PubMed id 19139490)2 Jia W.... Qian X.H. (Mol. Cell. Proteomics 2009)
    7. Structures of vertebrate hyaluronidases and their unique enzymatic mechanism of hydrolysis. (PubMed id 16104017)2 Jedrzejas M.J. and Stern R. (Proteins 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)2 Scherer S.W.... Tsui L.-C. (Science 2003)
    10. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23553 HGNC: 5323 AceView: HYAL4 Ensembl:ENSG00000106302 euGenes: HUgn23553
    ECgene: HYAL4 Kegg: 23553 H-InvDB: HYAL4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HYAL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HYAL4 gene:
    Search GeneIP for patents involving HYAL4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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