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Aliases for HYAL4 Gene

Aliases for HYAL4 Gene

  • Hyaluronoglucosaminidase 4 2 3
  • Chondroitin Sulfate Endo-Beta-N-Acetylgalactosaminidase 3 4
  • Chondroitin Sulfate Hydrolase 3 4
  • Hyaluronoglucosaminidase-4 3 4
  • Hyaluronidase 4 2 3
  • EC 4 63
  • Hyal-4 3 4
  • CSHY 3 4
  • Hyaluronidase-4 3
  • EC 3.2.1 63

External Ids for HYAL4 Gene

Previous GeneCards Identifiers for HYAL4 Gene

  • GC07P121963
  • GC07P123025
  • GC07P123039
  • GC07P123014
  • GC07P123079
  • GC07P123272
  • GC07P123469
  • GC07P117848

Summaries for HYAL4 Gene

Entrez Gene Summary for HYAL4 Gene

  • This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for HYAL4 Gene

HYAL4 (Hyaluronoglucosaminidase 4) is a Protein Coding gene. Diseases associated with HYAL4 include oxyphilic adenoma. Among its related pathways are Metabolism and Glycosaminoglycan degradation. GO annotations related to this gene include hyalurononglucosaminidase activity. An important paralog of this gene is HYAL3.

UniProtKB/Swiss-Prot for HYAL4 Gene

  • Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HYAL4 Gene

Genomics for HYAL4 Gene

Regulatory Elements for HYAL4 Gene

Genomic Location for HYAL4 Gene

123,828,983 bp from pter
123,877,478 bp from pter
48,496 bases
Plus strand

Genomic View for HYAL4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HYAL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HYAL4 Gene

Proteins for HYAL4 Gene

  • Protein details for HYAL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D0VXG1
    • Q9UL99
    • Q9Y6T9

    Protein attributes for HYAL4 Gene

    481 amino acids
    Molecular mass:
    54249 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HYAL4 Gene

Proteomics data for HYAL4 Gene at MOPED

Selected DME Specific Peptides for HYAL4 Gene

Post-translational modifications for HYAL4 Gene

  • Glycosylation at Asn86, Asn115, Asn177, and Asn343
  • Modification sites at PhosphoSitePlus

Other Protein References for HYAL4 Gene

Domains for HYAL4 Gene

Suggested Antigen Peptide Sequences for HYAL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q2M3T9
  • Belongs to the glycosyl hydrolase 56 family.
genes like me logo Genes that share domains with HYAL4: view

No data available for Gene Families for HYAL4 Gene

Function for HYAL4 Gene

Molecular function for HYAL4 Gene

GENATLAS Biochemistry: hyaluroglucosaminidase 4,differentially expressed in placenta and skeletal muscle,involved inglycosaminoglycan catabolism,clustered with HYAL1P1 and SPAM1
UniProtKB/Swiss-Prot BiophysicochemicalProperties: pH dependence: Optimum pH is 4.5-5 (for chondroitin sulfate hydrolase activity). {ECO:0000269 PubMed:19889881}; Temperature dependence: Optimum temperature is 37 degrees Celsius. {ECO:0000269 PubMed:19889881};
UniProtKB/Swiss-Prot CatalyticActivity: Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate
UniProtKB/Swiss-Prot Function: Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide.

Enzyme Numbers (IUBMB) for HYAL4 Gene

Gene Ontology (GO) - Molecular Function for HYAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004415 hyalurononglucosaminidase activity IEA --
genes like me logo Genes that share ontologies with HYAL4: view
genes like me logo Genes that share phenotypes with HYAL4: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HYAL4 Gene

Localization for HYAL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HYAL4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for HYAL4 Gene COMPARTMENTS Subcellular localization image for HYAL4 gene
Compartment Confidence
peroxisome 2
cytoskeleton 1
cytosol 1
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HYAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009986 cell surface IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HYAL4: view

Pathways for HYAL4 Gene

genes like me logo Genes that share pathways with HYAL4: view

Pathways by source for HYAL4 Gene

2 KEGG pathways for HYAL4 Gene
1 R&D Systems pathway for HYAL4 Gene

Interacting Proteins for HYAL4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000223026 for HYAL4 Gene via STRING

Gene Ontology (GO) - Biological Process for HYAL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006027 glycosaminoglycan catabolic process TAS 10493834
GO:0030207 chondroitin sulfate catabolic process IEA --
genes like me logo Genes that share ontologies with HYAL4: view

Transcripts for HYAL4 Gene

mRNA/cDNA for HYAL4 Gene

Unigene Clusters for HYAL4 Gene

Hyaluronoglucosaminidase 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HYAL4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HYAL4 Gene

No ASD Table

Relevant External Links for HYAL4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HYAL4 Gene

mRNA expression in normal human tissues for HYAL4 Gene

mRNA differential expression in normal tissues according to GTEx for HYAL4 Gene

This gene is overexpressed in Muscle - Skeletal (20.7), Testis (9.5), and Skin - Sun Exposed (Lower leg) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HYAL4 Gene

SOURCE GeneReport for Unigene cluster for HYAL4 Gene Hs.28673

mRNA Expression by UniProt/SwissProt for HYAL4 Gene

Tissue specificity: Detected in placenta and skeletal muscle.
genes like me logo Genes that share expressions with HYAL4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for HYAL4 Gene

Orthologs for HYAL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HYAL4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HYAL4 35
  • 99.1 (n)
  • 98.54 (a)
HYAL4 36
  • 99 (a)
(Bos Taurus)
Mammalia HYAL4 35
  • 87.36 (n)
  • 86.25 (a)
HYAL4 36
  • 86 (a)
(Canis familiaris)
Mammalia HYAL4 35
  • 89.37 (n)
  • 88.54 (a)
HYAL4 36
  • 88 (a)
(Mus musculus)
Mammalia Hyal4 35
  • 84.34 (n)
  • 79.63 (a)
Hyal4 16
Hyal4 36
  • 80 (a)
(Monodelphis domestica)
Mammalia HYAL4 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia HYAL4 36
  • 69 (a)
(Rattus norvegicus)
Mammalia Hyal4 35
  • 82.81 (n)
  • 78.17 (a)
(Gallus gallus)
Aves -- 36
  • 45 (a)
(Anolis carolinensis)
Reptilia HYAL4 36
  • 72 (a)
(Danio rerio)
Actinopterygii hyal4 36
  • 52 (a)
LOC100149853 35
  • 59.22 (n)
  • 59.07 (a)
(Caenorhabditis elegans)
Secernentea chhy-1 36
  • 27 (a)
T22C8.2 37
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for HYAL4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HYAL4 Gene

Gene Tree for HYAL4 (if available)
Gene Tree for HYAL4 (if available)

Paralogs for HYAL4 Gene

Paralogs for HYAL4 Gene

Selected SIMAP similar genes for HYAL4 Gene using alignment to 4 proteins: Pseudogenes for HYAL4 Gene

genes like me logo Genes that share paralogs with HYAL4: view

Variants for HYAL4 Gene

Sequence variations from dbSNP and Humsavar for HYAL4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs36926 -- 123,851,294(+) aatgt(A/G)tgggt intron-variant
rs36927 -- 123,855,051(+) ctgcc(G/T)ttttt intron-variant
rs36928 -- 123,861,563(+) ATACA(A/G)AGATA intron-variant
rs36929 -- 123,865,690(+) AATAC(C/T)ATGAG intron-variant
rs36930 -- 123,870,429(+) ATTGA(A/G)TGAAG intron-variant

Relevant External Links for HYAL4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HYAL4 Gene

Disorders for HYAL4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for HYAL4 Gene including...

Search for HYAL4 Gene in MalaCards »

(1) University of Copenhagen DISEASES for HYAL4 Gene

Relevant External Links for HYAL4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HYAL4: view

No data available for UniProtKB/Swiss-Prot for HYAL4 Gene

Publications for HYAL4 Gene

  1. Identification of human hyaluronidase-4 as a novel chondroitin sulfate hydrolase that preferentially cleaves the galactosaminidic linkage in the trisulfated tetrasaccharide sequence. (PMID: 19889881) Kaneiwa T. … Yamada S. (Glycobiology 2010) 3 4 23
  2. Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31. (PMID: 10493834) Csoka A.B. … Stern R. (Genomics 1999) 2 3 4
  3. Human hyaluronidases: electrophoretic multiple forms in somatic tissues and body fluids. Evidence for conserved hyaluronidase potential N-glycosylation sites in different mammalian species. (PMID: 10989127) Fiszer-Szafarz B. … Zou L. (J. Biochem. Biophys. Methods 2000) 3 23
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Identification of amino acid residues required for the substrate specificity of human and mouse chondroitin sulfate hydrolase (conventional hyaluronidase-4). (PMID: 23086929) Kaneiwa T. … Yamada S. (J. Biol. Chem. 2012) 3

Products for HYAL4 Gene

Sources for HYAL4 Gene

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