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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HYAL4 Gene

protein-coding   GIFtS: 55
GCID: GC07P123469

Hyaluronoglucosaminidase 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Hyaluronoglucosaminidase 41 2     hyal-42
Hyaluronidase 41 2     hyaluronidase-42
Chondroitin Sulfate Endo-Beta-N-Acetylgalactosaminidase2 3     hyaluronoglucosaminidase-42
Chondroitin Sulfate Hydrolase2 3     Hyal-43
CSHY2 3     Hyaluronoglucosaminidase-43
EC 3.2.1.353 8     EC 3.2.18

External Ids:    HGNC: 53231   Entrez Gene: 235532   Ensembl: ENSG000001063027   OMIM: 6045105   UniProtKB: Q2M3T93   

Export aliases for HYAL4 gene to outside databases

Previous GC identifers: GC07P121963 GC07P123025 GC07P123039 GC07P123014 GC07P123079 GC07P123272 GC07P117848


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HYAL4 Gene:
This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly
degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be
involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to
have hyaluronidase activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for HYAL4 Gene: 
HYAL4 (hyaluronoglucosaminidase 4) is a protein-coding gene. Diseases associated with HYAL4 include mucopolysaccharidosis type ix, and oxyphilic adenoma, and among its related super-pathways are Metabolism. GO annotations related to this gene include hyalurononglucosaminidase activity. An important paralog of this gene is SPAM1.

UniProtKB/Swiss-Prot: HYAL4_HUMAN, Q2M3T9
Function: Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin
sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a
trisulfated tetrasaccharide




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HYAL4 gene promoter:
         AhR   Arnt   MEF-2A   POU2F1   FOXO4   POU2F1b   POU2F1a   POU2F1c   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHYAL4 promoter sequence
   Search SABiosciences Chromatin IP Primers for HYAL4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HYAL4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.3   Ensembl cytogenetic band:  7q31.32   HGNC cytogenetic band: 7q31.3

HYAL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HYAL4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P123469:  view genomic region     (about GC identifiers)

Start:
123,469,037 bp from pter      End:
123,517,532 bp from pter
Size:
48,496 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 122,873,836-122,906,152     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HYAL4_HUMAN, Q2M3T9 (See protein sequence)
Recommended Name: Hyaluronidase-4  
Size: 481 amino acids; 54249 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: D0VXG1 Q9UL99 Q9Y6T9

Explore the universe of human proteins at neXtProt for HYAL4: NX_Q2M3T9

Explore proteomics data for HYAL4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q2M3T9

  • 2 DME Specific Peptides for HYAL4 (Q2M3T9)
     NWNSKDV  GLAVIDWE 

    HYAL4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HYAL4 Protein Expression
    REFSEQ proteins: NP_036401.2  
    ENSEMBL proteins: 
     ENSP00000419522   ENSP00000417872   ENSP00000223026   ENSP00000417186   ENSP00000420264  

    Human Recombinant Protein Products for HYAL4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for HYAL4
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    Novus Biologicals HYAL4 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HYAL4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    HYAL4 for ontologies           About GeneDecksing



    HYAL4 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for HYAL4 

    Assay Products for HYAL4: 
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    Cloud-Clone Corp. ELISAs for HYAL4 
    Cloud-Clone Corp. CLIAs for HYAL4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR013785 Aldolase_TIM
     IPR018155 Hyaluronidase
     IPR000742 EG-like_dom
     IPR017853 Glycoside_hydrolase_SF

    Graphical View of Domain Structure for InterPro Entry Q2M3T9

    ProtoNet protein and cluster: Q2M3T9

    1 Blocks protein domain: IPB001968 Glycosyl hydrolase family 56 signature

    UniProtKB/Swiss-Prot: HYAL4_HUMAN, Q2M3T9
    Similarity: Belongs to the glycosyl hydrolase 56 family


    HYAL4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HYAL4_HUMAN, Q2M3T9
    Function: Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin
    sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a
    trisulfated tetrasaccharide
    Catalytic activity: Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate
    residues in hyaluronate
    Biophysicochemical properties: pH dependence: Optimum pH is 4.5-5 (for chondroitin sulfate hydrolase activity);
    Temperature dependence: Optimum temperature is 37 degrees Celsius;

         Genatlas biochemistry entry for HYAL4:
    hyaluroglucosaminidase 4,differentially expressed in placenta and skeletal muscle,involved inglycosaminoglycan
    catabolism,clustered with HYAL1P1 and SPAM1

         Enzyme Numbers (IUBMB): EC 3.2.1.351 2 EC 3.2.12

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004415hyalurononglucosaminidase activity IEA--
         
    HYAL4 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for HYAL4:
     Decreased Hepatitis C virus re  Decreased Wnt reporter activit  Decreased number of cells in m  Decreased viability with pacli 
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HYAL4 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HYAL4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HYAL4 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HYAL4
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate HYAL4:
    hsa-miR-204 hsa-miR-211 hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidHYAL4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of HYAL4

    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HYAL4 (NM_012269)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HYAL4
    Sirion Biotech Customized lentivirus for stable overexpression of HYAL4 
                         Customized lentivirus expression plasmids for stable overexpression of HYAL4 

    Cell Line
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    Search LifeMap BioReagents cell lines for HYAL4
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HYAL4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HYAL4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.40
    2Articular Cartilage Extracellular Matrix
    Articular Cartilage Extracellular Matrix
    3Glycosaminoglycan degradation
    Glycosaminoglycan degradation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for HYAL4
        Articular Cartilage Extracellular Matrix



    2         Kegg Pathways  (Kegg details for HYAL4):
        Glycosaminoglycan degradation
    Metabolic pathways


    HYAL4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HYAL4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for HYAL4 (ENSP000002230264) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARSBENSP000002649144STRING: ENSP00000264914
    IDUAENSP000002479334STRING: ENSP00000247933
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process IEA--
    GO:0006027glycosaminoglycan catabolic process TAS10493834

    HYAL4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HYAL4

    Search CenterWatch for drugs/clinical trials and news about HYAL4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HYAL4 gene: 
    NM_012269.2  

    Unigene Cluster for HYAL4:

    Hyaluronoglucosaminidase 4
    Hs.28673  [show with all ESTs]
    Unigene Representative Sequence: AF009010
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489978 ENST00000488323 ENST00000223026(uc003vlc.3 uc011knz.2)
    ENST00000476325 ENST00000483878
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HYAL4
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate HYAL4:
    hsa-miR-204 hsa-miR-211 hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidHYAL4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HYAL4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HYAL4
    Clone
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    OriGene ORF clones in mouse, rat for HYAL4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HYAL4 (NM_012269)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HYAL4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HYAL4
    Sirion Biotech Customized lentivirus for stable overexpression of HYAL4 
                         Customized lentivirus expression plasmids for stable overexpression of HYAL4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HYAL4
    OriGene qSTAR qPCR primer pairs in human, mouse for HYAL4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HYAL4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HYAL4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HYAL4

    Additional mRNA sequence: 

    AB470346.1 AF009010.1 BC104788.1 BC104790.1 BC143654.1 

    2 DOTS entries:

    DT.310081  DT.121111654 

    14 AceView cDNA sequences:

    AI033437 AA252101 AI990387 AI381685 BX117836 R66097 AA252069 AF009010 
    NM_012269 AA252100 W92155 BG013757 W92156 R67698 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HYAL4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTTAACTG
    HYAL4 Expression
    About this image


    See HYAL4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HYAL4

    SOURCE GeneReport for Unigene cluster: Hs.28673

    UniProtKB/Swiss-Prot: HYAL4_HUMAN, Q2M3T9
    Tissue specificity: Detected in placenta and skeletal muscle

        SABiosciences Custom PCR Arrays for HYAL4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HYAL4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HYAL4 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hyal41 , 5 hyaluronoglucosaminidase 41, 5 84.34(n)1
    79.63(a)1
      6 (11.28 cM)5
    770421  NM_029848.11  NP_084124.11 
     247483295 
    lizard
    (Anolis carolinensis)
    Reptilia HYAL46
    Uncharacterized protein
    71(a)
    1 ↔ 1
    5(67267939-67281882)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001498531 hyaluronidase-4-like 59.22(n)
    59.07(a)
      100149853  XM_001922088.2  XP_001922123.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T22C8.23 hyaluronidase 30(a)   II(8614552-8617147)   --


    ENSEMBL Gene Tree for HYAL4 (if available)
    TreeFam Gene Tree for HYAL4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HYAL4 gene
    SPAM12  HYAL32  HYAL22  HYAL12  
    5 SIMAP similar genes for HYAL4 using alignment to 4 protein entries:     HYAL4_HUMAN (see all proteins):
    HYAL2    LOC402588    SPAM1    HYAL1    HYAL3

    HYAL4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HYAL4
    PGOHUM00000233547


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/639 SNPs in HYAL4 are shown (see all 639)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1865584801,2
    --123483497(+) CCTTCA/CTTTCA 1 -- us2k10--------
    rs1917643961,2
    --123483515(+) TGAATA/CTGACA 1 -- us2k10--------
    rs1835379721,2
    C--123483533(+) GTCTTC/GGGGTT 1 -- us2k10--------
    rs1881509981,2
    --123483589(+) TTGAAA/TGTTGG 1 -- us2k10--------
    rs1927341481,2
    --123483637(+) ATCCCA/GAAGAC 1 -- us2k10--------
    rs1448270521,2
    C--123483650(+) TTTTCC/TAACTT 1 -- us2k10--------
    rs1820671111,2
    --123483690(+) TACCAA/GTCAAA 1 -- us2k10--------
    rs1485941681,2
    --123483702(+) ATACAC/TTTGGT 1 -- us2k10--------
    rs1866686261,2
    --123483730(+) TATTTC/TTTGGA 1 -- us2k10--------
    rs1914701941,2
    --123484055(+) TGTCAA/GCTCAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HYAL4 (123469037 - 123517532 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HYAL4: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HYAL4
    DNA2.0 Custom Variant and Variant Library Synthesis for HYAL4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604510    OMIM disorders: --

    6 diseases for HYAL4:    About MalaCards
    mucopolysaccharidosis type ix    oxyphilic adenoma    mucopolysaccharidosis    adenoma
    prostate cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for HYAL4:
    Oxyphilic adenoma

    HYAL4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HYAL4
    Human Genome Epidemiology (HuGE) Navigator: HYAL4 (1 document)

    Export disorders for HYAL4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HYAL4 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with HYAL4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31. (PubMed id 10493834)1, 2, 3 Csoka A.B.... Stern R. (1999)
    2. Identification of human hyaluronidase-4 as a novel ch ondroitin sulfate hydrolase that preferentially cleaves the galactosaminidic li nkage in the trisulfated tetrasaccharide sequence. (PubMed id 19889881)1, 2, 9 Kaneiwa T....Yamada S. (2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Human hyaluronidases: electrophoretic multiple forms in somatic tissues and body fluids. Evidence for conserved hyaluronidase potential N-glycosylation sites in different mammalian species. (PubMed id 10989127)1, 9 Fiszer-Szafarz B....Zou L. (2000)
    5. Identification of amino acid residues required for the substrate specificity of human and mouse chondroitin sulfate hydrolase (convent ional hyaluronidase-4). (PubMed id 23086929)1 Kaneiwa T....Yamada S. (2012)
    6. Structures of vertebrate hyaluronidases and their unique enzymatic mechanism of hydrolysis. (PubMed id 16104017)2 Jedrzejas M.J. and Stern R. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)2 Scherer S.W.... Tsui L.-C. (2003)
    9. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23553 HGNC: 5323 AceView: HYAL4 Ensembl:ENSG00000106302 euGenes: HUgn23553
    ECgene: HYAL4 Kegg: 23553 H-InvDB: HYAL4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HYAL4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HYAL4 gene:
    Search GeneIP for patents involving HYAL4

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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