Aliases for HYAL4 Gene
External Ids for HYAL4 Gene
Previous GeneCards Identifiers for HYAL4 Gene
This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. [provided by RefSeq, Jul 2008]
GeneCards Summary for HYAL4 Gene
HYAL4 (Hyaluronoglucosaminidase 4) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan degradation and Articular Cartilage Extracellular Matrix Pathway. GO annotations related to this gene include hyalurononglucosaminidase activity. An important paralog of this gene is SPAM1.
UniProtKB/Swiss-Prot for HYAL4 Gene
Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide.