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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HYAL3 Gene

protein-coding   GIFtS: 56
GCID: GC03M050331

Hyaluronoglucosaminidase 3

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Hyaluronoglucosaminidase 31 2     LUCA-32
LUCA32 3 5     hyaluronidase-32
Lung Carcinoma Protein 32 3     Hyal-33
EC 3.2.1.353 8     Hyaluronoglucosaminidase-33
HYAL-32     LuCa-33

External Ids:    HGNC: 53221   Entrez Gene: 83722   Ensembl: ENSG000001867927   OMIM: 6040385   UniProtKB: O438203   

Export aliases for HYAL3 gene to outside databases

Previous GC identifers: GC03P049651 GC03P049819 GC03M050179 GC03M050284 GC03M050301 GC03M050305


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HYAL3 Gene:
This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade
hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan
plays a critical role in many biological processes including cell proliferation, migration and differentiation.
The encoded protein may also play an important role in sperm function. This gene is one of several related genes
in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript
variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms
have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on
the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the
first exon. (provided by RefSeq, Jan 2011)

GeneCards Summary for HYAL3 Gene: 
HYAL3 (hyaluronoglucosaminidase 3) is a protein-coding gene. Diseases associated with HYAL3 include mucopolysaccharidosis type ix, and nodular basal cell carcinoma, and among its related super-pathways are Metabolism. GO annotations related to this gene include virus receptor activity and hyaluronoglucuronidase activity. An important paralog of this gene is SPAM1.

Gene Wiki entry for HYAL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HYAL3 gene promoter:
         ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHYAL3 promoter sequence
   Search SABiosciences Chromatin IP Primers for HYAL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HYAL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

HYAL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HYAL3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M050331:  view genomic region     (about GC identifiers)

Start:
50,330,259 bp from pter      End:
50,336,899 bp from pter
Size:
6,641 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HYAL3_HUMAN, O43820 (See protein sequence)
Recommended Name: Hyaluronidase-3 precursor  
Size: 417 amino acids; 46501 Da
Subcellular location: Secreted (By similarity). Lysosome (By similarity)
Sequence caution: Sequence=AAC70915.1; Type=Frameshift; Positions=410;
Secondary accessions: O60540 Q8NFK2 Q8NFK3 Q8NFK4 Q96E56 Q9BRW9
Alternative splicing: 4 isoforms:  O43820-1   O43820-2   O43820-3   O43820-4   (Enzymatically inactive)

Explore the universe of human proteins at neXtProt for HYAL3: NX_O43820

Explore proteomics data for HYAL3 at MOPED 

4/9 DME Specific Peptides for HYAL3 (O43820) (see all 9)
 LDPQEQL  GWAGPTC  PLWAGNWG  GVVLWGDLS 

HYAL3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

HYAL3 Protein Expression
REFSEQ proteins (5 alternative transcripts): 
NP_001186958.1  NP_001186959.1  NP_001186960.1  NP_001186961.1  NP_003540.2  

ENSEMBL proteins: 
 ENSP00000351946   ENSP00000337425   ENSP00000401092   ENSP00000424633   ENSP00000391663  
 ENSP00000391922  

Human Recombinant Protein Products for HYAL3: 
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Cloud-Clone Corp. Proteins for HYAL3 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--
GO:0005764lysosome IDA16600643
GO:0031410cytoplasmic vesicle IDA18390475

HYAL3 for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for HYAL3


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
5 InterPro protein domains:
 IPR013785 Aldolase_TIM
 IPR018155 Hyaluronidase
 IPR000742 EG-like_dom
 IPR017853 Glycoside_hydrolase_SF
 IPR027260 Hyaluronidase-3

Graphical View of Domain Structure for InterPro Entry O43820

ProtoNet protein and cluster: O43820

2 Blocks protein domains:
IPB001968 Glycosyl hydrolase family 56 signature
IPB006210 Type I EGF


UniProtKB/Swiss-Prot: HYAL3_HUMAN, O43820
Similarity: Belongs to the glycosyl hydrolase 56 family
Similarity: Contains 1 EGF-like domain


HYAL3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: HYAL3_HUMAN, O43820
Catalytic activity: Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate
residues in hyaluronate

     Genatlas biochemistry entry for HYAL3:
hyaluroglucosaminidase 3,secreted in the sperm and involved in fertilization,involved in glycosaminoglycan
catabolism

     Enzyme Number (IUBMB): EC 3.2.1.351 2

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001618NOT virus receptor activity IDA11296287
GO:0004415NOT hyalurononglucosaminidase activity IDA12084718
GO:0033906hyaluronoglucuronidase activity IDA--
     
HYAL3 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for HYAL3 
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   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HYAL3 
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miRNA
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SwitchGear 3'UTR luciferase reporter plasmidHYAL3 3' UTR sequence
Inhib. RNA
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HYAL3


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for HYAL3 About                                                                                                See pathways by source

SuperPathContained pathways About
1Metabolism
Metabolic pathways0.40
2Glycosaminoglycan degradation
Glycosaminoglycan degradation

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



2         Kegg Pathways  (Kegg details for HYAL3):
    Glycosaminoglycan degradation
Metabolic pathways


HYAL3 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HYAL3

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/8 Interacting proteins for HYAL3 (ENSP000003374254) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
InteractantInteraction Details
GeneCardExternal ID(s)
ARSBENSP000002649144STRING: ENSP00000264914
IDUAENSP000002479334STRING: ENSP00000247933
NBL1ENSP000002897494STRING: ENSP00000289749
TARS2ENSP000003580604STRING: ENSP00000358060
SLC22A2ENSP000003559204STRING: ENSP00000355920
About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005975carbohydrate metabolic process IEA--
GO:0006954inflammatory response IDA18390475
GO:0009615response to virus IDA11296287
GO:0030214hyaluronan catabolic process IDA12084718
GO:0046677response to antibiotic IEP11944887

HYAL3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HYAL3

Search CenterWatch for drugs/clinical trials and news about HYAL3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HYAL3 gene (5 alternative transcripts): 
NM_001200029.1  NM_001200030.1  NM_001200031.1  NM_001200032.1  NM_003549.3  

Unigene Clusters for HYAL3:

Hyaluronoglucosaminidase 3
Hs.129910  [show with all ESTs], Hs.729310  [show with all ESTs]
Unigene Representative Sequences: NM_001200030, NM_003549
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000359051 ENST00000336307(uc021wyn.1 uc003cze.2 uc003czf.2 uc003czd.2 uc003czg.2)
ENST00000415204 ENST00000513170 ENST00000435141 ENST00000450982
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
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3 QIAGEN miScript miRNA Assays for microRNAs that regulate HYAL3:
hsa-miR-3164 hsa-miR-1322 hsa-miR-1272
SwitchGear 3'UTR luciferase reporter plasmidHYAL3 3' UTR sequence
Inhib. RNA
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Clone
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OriGene ORF clones in mouse, rat for HYAL3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HYAL3
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HYAL3

Additional mRNA sequence: 

AF036035.1 AF502910.1 AF502912.1 AK313455.1 BC005896.1 BC012892.1 

11 DOTS entries:

DT.308846  DT.97831606  DT.111521  DT.100776985  DT.92421490  DT.100018143  DT.100776986  DT.97840361 
DT.100689479  DT.70103718  DT.92421491 

24/510 AceView cDNA sequences (see all 510):

AW960774 AF502910 BE904712 CR594453 CR613438 BM918332 AA579404 BX283184 
BE563312 AI290004 AW409968 AI803247 BG828990 BM874367 BG760348 CB305671 
BE891313 NM_012191 BI821378 BM806185 BC007265 CK724916 AF502912 BQ222461 

GeneLoc Exon Structure

5/27 Alternative Splicing Database (ASD) splice patterns (SP) for HYAL3 (see all 27)    About this scheme

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ·
SP1:                                                                                                                                                            
SP2:                                                                                                                                                            
SP3:                                                                                                                                                            
SP4:                                                                                                                                                            
SP5:                                                                                                                                                            

ExUns: 11d · 11e ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d · 15e ^ 16a · 16b · 16c · 16d ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21a · 21b ^ 22a ·
SP1:              -     -     -                                               -                                                           -     -               
SP2:              -     -     -           -     -                             -                                                                                 
SP3:                                                                          -                                                           -     -               
SP4:              -     -     -                                               -                                                                                 
SP5:                                                                                                                                      -     -               

ExUns: 22b ^ 23a · 23b · 23c ^ 24a · 24b
SP1:  -                 -               
SP2:                                    
SP3:                                    
SP4:                                    
SP5:  -                                 


ECgene alternative splicing isoforms for HYAL3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HYAL3 expression in normal human tissues (normalized intensities)      HYAL3 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAGAGGTCAC
HYAL3 Expression
About this image


HYAL3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/1 selected tissues (see all 1) fully expand
 
 Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
         Articular Cartilage Cells Zeugopod Articular Cartilage

See HYAL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HYAL3

SOURCE GeneReport for Unigene clusters: Hs.129910 Hs.729310

UniProtKB/Swiss-Prot: HYAL3_HUMAN, O43820
Tissue specificity: Bone marrow, testis and kidney. Isoform 4 is detected in all bladder tumor and prostate tumor
cells

    SABiosciences Custom PCR Arrays for HYAL3
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HYAL3
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HYAL3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HYAL3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HYAL3 gene from 5/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Hyal31 , 5 hyaluronoglucosaminidase 31, 5 81.43(n)1
79.08(a)1
  9 (58.19 cM)5
1096851  NM_178020.31  NP_821139.21 
 1075808185 
chicken
(Gallus gallus)
Aves LOC1008599031 hyaluronidase-3-like 62.4(n)
57.8(a)
  100859903  XM_003641994.1  XP_003642042.1 
lizard
(Anolis carolinensis)
Reptilia HYAL36
Uncharacterized protein
47(a)
1 ↔ 1
2(149861725-149866002)
zebrafish
(Danio rerio)
Actinopterygii hyal31 hyaluronoglucosaminidase 3 50.87(n)
46.4(a)
  100004557  NM_001128293.1  NP_001121765.1 
worm
(Caenorhabditis elegans)
Secernentea T22C8.23 hyaluronidase 29(a)   II(8614552-8617147)   --


ENSEMBL Gene Tree for HYAL3 (if available)
TreeFam Gene Tree for HYAL3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for HYAL3 gene
SPAM12  HYAL22  HYAL12  HYAL42  
6 SIMAP similar genes for HYAL3 using alignment to 3 protein entries:     HYAL3_HUMAN (see all proteins):
NAT6    HYAL4    HYAL1    HYAL2    LOC402588    SPAM1

HYAL3 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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10/58 SNPs in HYAL3 are shown (see all 58)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1890653541,2
C--50332228(+) CCACAC/TGGAAG 10 H R mis10--------
rs1479092731,2
C,F--50332262(+) AAAGGC/TCTGGT 10 T A mis11Minor allele frequency- T:0.00NA 4550
rs1412856291,2
C--50332355(+) GTTGCG/AGGCAA 8 /R /C mis1 int11Minor allele frequency- A:0.00NA 4544
rs1423154211,2
C,F--50332378(+) GGCAGC/TGGCCG 8 H R mis1 int11Minor allele frequency- T:0.00NA 4532
rs1492483621,2
C--50332459(+) GGGGCC/TGTAGT 8 Q R mis1 int11Minor allele frequency- T:0.00NA 4524
rs1379371921,2
C--50332460(+) GGGCCG/ATAGTG 8 /R /W mis1 int11Minor allele frequency- A:0.00NA 4522
rs1999643341,2
C--50332477(+) CCACCA/CGCAGC 8 R L mis1 int10--------
rs1397565961,2
C,F--50332501(+) GTGCAC/TGGGCC 8 H R mis1 int12Minor allele frequency- T:0.00NA EU 5555
rs2007400721,2
C--50332521(+) AAGCCA/GGTATA 8 T syn1 int11Minor allele frequency- G:0.00EU 1087
rs2011861841,2
--50332554(+) GGGTCC/TAGGTC 8 L syn1 int10--------

HapMap Linkage Disequilibrium report for HYAL3 (50330259 - 50336899 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/12 variations for HYAL3 (see all 12):    About this table     
Variant IDTypeSubtypePubMed ID
dgv5132n71CNV Loss21882294
nsv523662CNV Loss19592680
nsv876770CNV Loss21882294
nsv3813CNV Loss18451855
dgv5131n71CNV Loss21882294
nsv876769CNV Loss21882294
nsv834692CNV Loss17160897
nsv470561CNV Loss18288195
nsv834693CNV Loss17160897
nsv523560CNV Loss19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604038    OMIM disorders: --

8 diseases for HYAL3:    About MalaCards
mucopolysaccharidosis type ix    nodular basal cell carcinoma    mucopolysaccharidosis    basal cell carcinoma
lung cancer    colorectal cancer    prostate cancer    prostatitis


HYAL3 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

1 Novoseek inferred disease relationship for HYAL3 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
tumors 0 3 11802201 (3)


Export disorders for HYAL3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for HYAL3 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with HYAL3)
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  1. Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31. (PubMed id 10493834)1, 2, 3 Csoka A.B.... Stern R. (1999)
  2. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (2006)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Regulation of hyaluronidase activity by alternative mRNA splicing. (PubMed id 12084718)1, 2 Lokeshwar V.B.... Iida N. (2002)
  5. Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines. (PubMed id 12684632)1, 9 Junker N....Kristjansen P.E. (2003)
  6. Expression of hyaluronan synthases and hyaluronidases in the MG63 osteoblast cell line. (PubMed id 16203124)1, 9 Adams J.R....Byers S. (2006)
  7. Analysis of HYAL3 gene mutations in Chinese lung squam ous cell carcinoma patients. (PubMed id 23549009)1 Zhang R.X....Ji X.Q. (2013)
  8. Genetic association and gene-gene interaction of HAS2, HABP1 and HYAL3 implicate hyaluronan metabolic genes in glaucomatous neurodegen eration. (PubMed id 22960332)1 Basu K....Mukhopadhyay A. (2012)
  9. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
  10. Involvement of hyaluronidases in colorectal cancer. (PubMed id 20849597)1 Bouga H....Vynios D.H. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8372 HGNC: 5322 AceView: HYAL3 Ensembl:ENSG00000186792 euGenes: HUgn8372
ECgene: HYAL3 Kegg: 8372 H-InvDB: HYAL3

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for HYAL3 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HYAL3 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for HYAL3 gene:
Search GeneIP for patents involving HYAL3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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