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Aliases for HYAL3 Gene

Aliases for HYAL3 Gene

  • Hyaluronoglucosaminidase 3 2 3 5
  • Lung Carcinoma Protein 3 3 4
  • EC 3.2.1.35 4 63
  • HYAL-3 3 4
  • LUCA-3 3 4
  • LUCA3 3 4
  • Hyaluronoglucosaminidase-3 4

External Ids for HYAL3 Gene

Previous GeneCards Identifiers for HYAL3 Gene

  • GC03P049651
  • GC03P049819
  • GC03M050179
  • GC03M050284
  • GC03M050301
  • GC03M050305
  • GC03M050331

Summaries for HYAL3 Gene

Entrez Gene Summary for HYAL3 Gene

  • This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]

GeneCards Summary for HYAL3 Gene

HYAL3 (Hyaluronoglucosaminidase 3) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan degradation and Glycosaminoglycan metabolism. GO annotations related to this gene include virus receptor activity and hyaluronoglucuronidase activity. An important paralog of this gene is HYAL1.

Gene Wiki entry for HYAL3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HYAL3 Gene

Genomics for HYAL3 Gene

Regulatory Elements for HYAL3 Gene

Enhancers for HYAL3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HYAL3 on UCSC Golden Path with GeneCards custom track

Promoters for HYAL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HYAL3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the HYAL3 gene promoter:

Genomic Location for HYAL3 Gene

Chromosome:
3
Start:
50,292,828 bp from pter
End:
50,299,468 bp from pter
Size:
6,641 bases
Orientation:
Minus strand

Genomic View for HYAL3 Gene

Genes around HYAL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HYAL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HYAL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HYAL3 Gene

Proteins for HYAL3 Gene

  • Protein details for HYAL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43820-HYAL3_HUMAN
    Recommended name:
    Hyaluronidase-3
    Protein Accession:
    O43820
    Secondary Accessions:
    • O60540
    • Q8NFK2
    • Q8NFK3
    • Q8NFK4
    • Q96E56
    • Q9BRW9

    Protein attributes for HYAL3 Gene

    Size:
    417 amino acids
    Molecular mass:
    46501 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC70915.1; Type=Frameshift; Positions=410; Evidence={ECO:0000305};

    Alternative splice isoforms for HYAL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HYAL3 Gene

Proteomics data for HYAL3 Gene at MOPED

Post-translational modifications for HYAL3 Gene

  • Glycosylation at Asn 69 and Asn 215

Domains & Families for HYAL3 Gene

Suggested Antigen Peptide Sequences for HYAL3 Gene

Graphical View of Domain Structure for InterPro Entry

O43820

UniProtKB/Swiss-Prot:

HYAL3_HUMAN :
  • Contains 1 EGF-like domain.
  • Belongs to the glycosyl hydrolase 56 family.
Domain:
  • Contains 1 EGF-like domain.
Family:
  • Belongs to the glycosyl hydrolase 56 family.
genes like me logo Genes that share domains with HYAL3: view

No data available for Gene Families for HYAL3 Gene

Function for HYAL3 Gene

Molecular function for HYAL3 Gene

GENATLAS Biochemistry:
hyaluroglucosaminidase 3,secreted in the sperm and involved in fertilization,involved in glycosaminoglycan catabolism
UniProtKB/Swiss-Prot CatalyticActivity:
Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Enzyme Numbers (IUBMB) for HYAL3 Gene

genes like me logo Genes that share phenotypes with HYAL3: view

Animal Models for HYAL3 Gene

MGI Knock Outs for HYAL3:

Animal Model Products

miRNA for HYAL3 Gene

miRTarBase miRNAs that target HYAL3

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HYAL3 Gene

Localization for HYAL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HYAL3 Gene

Secreted. Lysosome.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for HYAL3 Gene

Pathways & Interactions for HYAL3 Gene

genes like me logo Genes that share pathways with HYAL3: view

Interacting Proteins for HYAL3 Gene

Selected Interacting proteins: O43820-HYAL3_HUMAN for HYAL3 Gene via UniProtKB

Symbol External ID(s) Details
DAB1

Gene Ontology (GO) - Biological Process for HYAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006954 inflammatory response IDA 18390475
GO:0046677 response to antibiotic IEP 11944887
GO:0071356 cellular response to tumor necrosis factor IEP 18390475
genes like me logo Genes that share ontologies with HYAL3: view

No data available for SIGNOR curated interactions for HYAL3 Gene

Drugs & Compounds for HYAL3 Gene

(2) Additional Compounds for HYAL3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
N-Acetylgalactosamine 4-sulphate
  • 2-(Acetylamino)-2-deoxy-D-Galactose 4-(hydrogen sulfate)
  • 2-(Acetylamino)-2-deoxy-D-Galactose 4-(hydrogen sulphate)
  • GalNAc4S
  • N-Acetyl-D-galactosamine 4-sulfate
  • N-Acetyl-D-galactosamine 4-sulphate
45233-43-0
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with HYAL3: view

Transcripts for HYAL3 Gene

Unigene Clusters for HYAL3 Gene

Hyaluronoglucosaminidase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HYAL3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - - - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - - - -
SP19: - - - - -
SP20: - -
SP21: -
SP22:
SP23: - - - - - - - - -
SP24: - -
SP25: - - -
SP26:
SP27: -

ExUns: 11d · 11e ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d · 15e ^ 16a · 16b · 16c · 16d ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21a · 21b ^ 22a ·
SP1: - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: - -
SP7: - -
SP8:
SP9:
SP10: - - - -
SP11: - - -
SP12:
SP13: - - -
SP14: - - - -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:

ExUns: 22b ^ 23a · 23b · 23c ^ 24a · 24b
SP1: - -
SP2:
SP3:
SP4:
SP5: -
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:

Relevant External Links for HYAL3 Gene

GeneLoc Exon Structure for
HYAL3
ECgene alternative splicing isoforms for
HYAL3

Expression for HYAL3 Gene

mRNA expression in normal human tissues for HYAL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HYAL3 Gene

This gene is overexpressed in Testis (x4.9).

SOURCE GeneReport for Unigene cluster for HYAL3 Gene Hs.129910

mRNA Expression by UniProt/SwissProt for HYAL3 Gene

O43820-HYAL3_HUMAN
Tissue specificity: Bone marrow, testis and kidney. Isoform 4 is detected in all bladder tumor and prostate tumor cells.
genes like me logo Genes that share expression patterns with HYAL3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for HYAL3 Gene

Orthologs for HYAL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HYAL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HYAL3 35
  • 86.7 (n)
  • 82.21 (a)
-- 36
  • 32 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia HYAL3 35
  • 86.87 (n)
  • 81.54 (a)
HYAL3 36
  • 54 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hyal3 35
  • 81.43 (n)
  • 79.08 (a)
Hyal3 16
Hyal3 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HYAL3 35
  • 99.44 (n)
  • 99.28 (a)
HYAL3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hyal3 35
  • 83.62 (n)
  • 81.02 (a)
oppossum
(Monodelphis domestica)
Mammalia HYAL3 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 36 (a)
ManyToMany
chicken
(Gallus gallus)
Aves HYAL3 35
  • 62.66 (n)
  • 58.31 (a)
HYAL3 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HYAL3 36
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii hyal3 35
  • 50.66 (n)
  • 46.06 (a)
hyal3 36
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T22C8.2 37
  • 29 (a)
chhy-1 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for HYAL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HYAL3 Gene

ENSEMBL:
Gene Tree for HYAL3 (if available)
TreeFam:
Gene Tree for HYAL3 (if available)

Paralogs for HYAL3 Gene

Paralogs for HYAL3 Gene

(6) SIMAP similar genes for HYAL3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HYAL3: view

Variants for HYAL3 Gene

Sequence variations from dbSNP and Humsavar for HYAL3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs13100173 - 50,295,266(+) GTGGT(A/G)GATCT intron-variant, reference, missense
rs35125558 -- 50,295,815(+) GGCAT(C/G)GAGTG intron-variant
rs139756596 -- 50,295,070(+) GTGCA(C/T)GGGCC intron-variant, reference, missense
rs146737984 -- 50,295,175(+) AAGCT(C/T)GGCGG intron-variant, reference, missense
rs149980641 -- 50,294,732(+) AGATC(C/T)CCGGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for HYAL3 Gene

Variant ID Type Subtype PubMed ID
nsv523662 CNV Loss 19592680
nsv876769 CNV Loss 21882294
nsv470561 CNV Loss 18288195
nsv876770 CNV Loss 21882294
nsv523560 CNV Loss 19592680
dgv1456e1 CNV Complex 17122850
nsv834692 CNV Loss 17160897
nsv460531 CNV Loss 19166990
dgv5131n71 CNV Loss 21882294
dgv5132n71 CNV Loss 21882294
nsv834693 CNV Loss 17160897
nsv3813 CNV Loss 18451855

Variation tolerance for HYAL3 Gene

Residual Variation Intolerance Score: 32.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.75; 73.37% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HYAL3 Gene

Disorders for HYAL3 Gene

Relevant External Links for HYAL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HYAL3

No disorders were found for HYAL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HYAL3 Gene

Publications for HYAL3 Gene

  1. Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31. (PMID: 10493834) Csoka A.B. … Stern R. (Genomics 1999) 2 3 4 67
  2. Expression of hyaluronan synthases and hyaluronidases in the MG63 osteoblast cell line. (PMID: 16203124) Adams J.R. … Byers S. (Matrix Biol. 2006) 3 23
  3. Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines. (PMID: 12684632) Junker N. … Kristjansen P.E. (Oncol. Rep. 2003) 3 23
  4. Hyalurosome gene regulation and dose-dependent restoration of skin atrophy by retinaldehyde and defined-size hyaluronate fragments in dermatoporosis. (PMID: 25138066) Nikolic D.S. … Kaya G. (Dermatology (Basel) 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for HYAL3 Gene

Sources for HYAL3 Gene

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