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HYAL3 Gene

protein-coding   GIFtS: 58
GCID: GC03M050331

Hyaluronoglucosaminidase 3

  See HYAL3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hyaluronoglucosaminidase 31 2     LUCA-32
LUCA32 3 5     hyaluronidase-32
Lung Carcinoma Protein 32 3     Hyal-33
EC 3.2.1.353 8     Hyaluronoglucosaminidase-33
HYAL-32     LuCa-33

External Ids:    HGNC: 53221   Entrez Gene: 83722   Ensembl: ENSG000001867927   OMIM: 6040385   UniProtKB: O438203   

Export aliases for HYAL3 gene to outside databases

Previous GC identifers: GC03P049651 GC03P049819 GC03M050179 GC03M050284 GC03M050301 GC03M050305


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HYAL3 Gene:
This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade
hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan
plays a critical role in many biological processes including cell proliferation, migration and differentiation.
The encoded protein may also play an important role in sperm function. This gene is one of several related genes
in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript
variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms
have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on
the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the
first exon. (provided by RefSeq, Jan 2011)

GeneCards Summary for HYAL3 Gene:
HYAL3 (hyaluronoglucosaminidase 3) is a protein-coding gene. Diseases associated with HYAL3 include mucopolysaccharidosis ix, and nodular basal cell carcinoma. GO annotations related to this gene include virus receptor activity and hyaluronoglucuronidase activity. An important paralog of this gene is SPAM1.

Gene Wiki entry for HYAL3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the HYAL3 gene promoter:
         ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHYAL3 promoter sequence
   Search Chromatin IP Primers for HYAL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HYAL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

HYAL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HYAL3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M050331:  view genomic region     (about GC identifiers)

Start:
50,330,259 bp from pter      End:
50,336,899 bp from pter
Size:
6,641 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HYAL3_HUMAN, O43820 (See protein sequence)
Recommended Name: Hyaluronidase-3 precursor  
Size: 417 amino acids; 46501 Da
Sequence caution: Sequence=AAC70915.1; Type=Frameshift; Positions=410;
Secondary accessions: O60540 Q8NFK2 Q8NFK3 Q8NFK4 Q96E56 Q9BRW9
Alternative splicing: 4 isoforms:  O43820-1   O43820-2   O43820-3   O43820-4   (Enzymatically inactive)

Explore the universe of human proteins at neXtProt for HYAL3: NX_O43820

Explore proteomics data for HYAL3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn69, Asn215
  • Selected DME Specific Peptides for HYAL3 (O43820) (see all 9)
     LDPQEQL  GWAGPTC  PLWAGNWG  GVVLWGDLS 


    See HYAL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001186958.1  NP_001186959.1  NP_001186960.1  NP_001186961.1  NP_003540.2  

    ENSEMBL proteins: 
     ENSP00000351946   ENSP00000337425   ENSP00000401092   ENSP00000424633   ENSP00000391663  
     ENSP00000391922  
    Reactome Protein details: O43820

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    antibodies-online proteins for HYAL3 (9 products) 

     
    antibodies-online peptides for HYAL3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR013785 Aldolase_TIM
     IPR018155 Hyaluronidase
     IPR000742 EG-like_dom
     IPR017853 Glycoside_hydrolase_SF
     IPR027260 Hyaluronidase-3

    Graphical View of Domain Structure for InterPro Entry O43820

    ProtoNet protein and cluster: O43820

    2 Blocks protein domains:
    IPB001968 Glycosyl hydrolase family 56 signature
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: HYAL3_HUMAN, O43820
    Similarity: Belongs to the glycosyl hydrolase 56 family
    Similarity: Contains 1 EGF-like domain


    Find genes that share domains with HYAL3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HYAL3_HUMAN, O43820
    Catalytic activity: Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate
    residues in hyaluronate

         Genatlas biochemistry entry for HYAL3:
    hyaluroglucosaminidase 3,secreted in the sperm and involved in fertilization,involved in glycosaminoglycan
    catabolism

         Enzyme Number (IUBMB): EC 3.2.1.351 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618NOT virus receptor activity IDA11296287
    GO:0004415NOT hyalurononglucosaminidase activity IDA12084718
    GO:0033906hyaluronoglucuronidase activity IDA--
         
    Find genes that share ontologies with HYAL3           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HYAL3

    miRNA
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    miRTarBase miRNAs that target HYAL3:
    hsa-mir-16-5p (MIRT031666)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HYAL3_HUMAN, O43820: Secreted (By similarity). Lysosome (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    lysosome5
    vacuole5
    extracellular3
    cytosol1
    endosome1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005764lysosome IDA16600643
    GO:0031410cytoplasmic vesicle IDA18390475

    Find genes that share ontologies with HYAL3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HYAL3 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    2MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIID - Sanfilippo syndrome D0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS I - Hurler syndrome0.45
    MPS IV - Morquio syndrome A0.45
    MPS IV - Morquio syndrome B0.45
    MPS IIIA - Sanfilippo syndrome A0.45
    MPS VII - Sly syndrome0.45
    3Chondroitin sulfate/dermatan sulfate metabolism
    Chondroitin sulfate/dermatan sulfate metabolism0.51
    CS/DS degradation0.00
    4Glycosaminoglycan degradation
    Glycosaminoglycan degradation
    5Disease
    Disease


    Find genes that share SuperPaths with HYAL3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for HYAL3
        Hyaluronan uptake and degradation
    CS/DS degradation


    2 Kegg Pathways  (Kegg details for HYAL3):
        Glycosaminoglycan degradation
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HYAL3
    Interactions:

        Search GeneGlobe Interaction Network for HYAL3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for HYAL3 (ENSP000003374254) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARSBENSP000002649144STRING: ENSP00000264914
    IDUAENSP000002479334STRING: ENSP00000247933
    NBL1ENSP000002897494STRING: ENSP00000289749
    TARS2ENSP000003580604STRING: ENSP00000358060
    SLC22A2ENSP000003559204STRING: ENSP00000355920
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process IEA--
    GO:0006954inflammatory response IDA18390475
    GO:0009615response to virus IDA11296287
    GO:0030214hyaluronan catabolic process IDA12084718
    GO:0046677response to antibiotic IEP11944887

    Find genes that share ontologies with HYAL3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HYAL3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HYAL3 gene (5 alternative transcripts): 
    NM_001200029.1  NM_001200030.1  NM_001200031.1  NM_001200032.1  NM_003549.3  

    Unigene Cluster for HYAL3:

    Hyaluronoglucosaminidase 3
    Hs.129910  [show with all ESTs]
    Unigene Representative Sequence: NM_001200030
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359051 ENST00000336307(uc021wyn.1 uc003cze.2 uc003czf.2 uc003czd.2 uc003czg.2)
    ENST00000415204 ENST00000513170 ENST00000435141 ENST00000450982
    miRNA
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    hsa-miR-3164 hsa-miR-1322 hsa-miR-1272
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    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat HYAL3

    Additional mRNA sequence: 

    AF040705.1 AF040706.1 AF502909.1 AF502911.1 AK313803.1 BC004483.2 CR457113.1 

    11 DOTS entries:

    DT.308846  DT.97831606  DT.111521  DT.100776985  DT.92421490  DT.100018143  DT.100776986  DT.97840361 
    DT.100689479  DT.92421491  DT.70103718 

    Selected AceView cDNA sequences (see all 510):

    BQ641373 BC001676 NM_006764 BM841031 AA857646 CR592164 BM793195 CR609875 
    BM669023 BM841635 BG258392 BU191968 AI584127 AI268721 AW167702 AA897469 
    BQ052249 BE904712 AI290004 BP364738 BG828990 BM827282 BM874367 BX283184 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HYAL3 (see all 27)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 11d · 11e ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d · 15e ^ 16a · 16b · 16c · 16d ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20 ^ 21a · 21b ^ 22a ·
    SP1:              -     -     -                                               -                                                           -     -               
    SP2:              -     -     -           -     -                             -                                                                                 
    SP3:                                                                          -                                                           -     -               
    SP4:              -     -     -                                               -                                                                                 
    SP5:                                                                                                                                      -     -               

    ExUns: 22b ^ 23a · 23b · 23c ^ 24a · 24b
    SP1:  -                 -               
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:  -                                 


    ECgene alternative splicing isoforms for HYAL3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HYAL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAGGTCAC
    HYAL3 Expression
    About this image


    HYAL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Articular Cartilage Cells Autopod Articular Cartilage
    HYAL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HYAL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.129910

    UniProtKB/Swiss-Prot: HYAL3_HUMAN, O43820
    Tissue specificity: Bone marrow, testis and kidney. Isoform 4 is detected in all bladder tumor and prostate tumor
    cells

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HYAL3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hyal31 , 5 hyaluronoglucosaminidase 31, 5 81.43(n)1
    79.08(a)1
      9 (58.19 cM)5
    1096851  NM_178020.31  NP_821139.21 
     1075808185 
    chicken
    (Gallus gallus)
    Aves HYAL31 hyaluronoglucosaminidase 3 62.66(n)
    58.31(a)
      100859903  XM_004944461.1  XP_004944518.1 
    lizard
    (Anolis carolinensis)
    Reptilia HYAL36
    hyaluronoglucosaminidase 3
    47(a)
    1 ↔ 1
    2(149861725-149866002)
    zebrafish
    (Danio rerio)
    Actinopterygii hyal31 hyaluronoglucosaminidase 3 50.66(n)
    46.06(a)
      100004557  NM_001128293.1  NP_001121765.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T22C8.23 hyaluronidase 29(a)   II(8614552-8617147)   --


    ENSEMBL Gene Tree for HYAL3 (if available)
    TreeFam Gene Tree for HYAL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HYAL3 gene
    SPAM12  HYAL22  HYAL12  HYAL42  
    6 SIMAP similar genes for HYAL3 using alignment to 3 protein entries:     HYAL3_HUMAN (see all proteins):
    NAT6    HYAL4    HYAL1    HYAL2    LOC402588    SPAM1

    Find genes that share paralogs with HYAL3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HYAL3 (see all 58)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1890653541,2
    C--50332228(+) CCACAC/TGGAAG 10 H R mis10--------
    rs1479092731,2
    C,F--50332262(+) AAAGGC/TCTGGT 10 T A mis11Minor allele frequency- T:0.00NA 4550
    rs1412856291,2
    C--50332355(+) GTTGCG/AGGCAA 8 /R /C mis1 int11Minor allele frequency- A:0.00NA 4544
    rs1423154211,2
    C,F--50332378(+) GGCAGC/TGGCCG 8 H R mis1 int11Minor allele frequency- T:0.00NA 4532
    rs1492483621,2
    C--50332459(+) GGGGCC/TGTAGT 8 Q R mis1 int11Minor allele frequency- T:0.00NA 4524
    rs1379371921,2
    C--50332460(+) GGGCCG/ATAGTG 8 /R /W mis1 int11Minor allele frequency- A:0.00NA 4522
    rs1999643341,2
    C--50332477(+) CCACCA/CGCAGC 8 R L mis1 int10--------
    rs1397565961,2
    C,F--50332501(+) GTGCAC/TGGGCC 8 H R mis1 int12Minor allele frequency- T:0.00NA EU 5555
    rs2007400721,2
    C--50332521(+) AAGCCA/GGTATA 8 T syn1 int11Minor allele frequency- G:0.00EU 1087
    rs2011861841,2
    --50332554(+) GGGTCC/TAGGTC 8 L syn1 int10--------

    HapMap Linkage Disequilibrium report for HYAL3 (50330259 - 50336899 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HYAL3 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv5132n71CNV Loss21882294
    nsv523662CNV Loss19592680
    nsv876770CNV Loss21882294
    nsv3813CNV Loss18451855
    dgv5131n71CNV Loss21882294
    nsv876769CNV Loss21882294
    nsv834692CNV Loss17160897
    nsv470561CNV Loss18288195
    nsv834693CNV Loss17160897
    nsv523560CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HYAL3
    DNA2.0 Custom Variant and Variant Library Synthesis for HYAL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604038    OMIM disorders: --

    3 diseases for HYAL3:    
    About MalaCards
    mucopolysaccharidosis ix    nodular basal cell carcinoma    lung squamous cell carcinoma


    Find genes that share disorders with HYAL3           About GenesLikeMe

    1 Novoseek inferred disease relationship for HYAL3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 11802201 (3)


    Export disorders for HYAL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HYAL3 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with HYAL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31. (PubMed id 10493834)1, 2, 3 Csoka A.B.... Stern R. (Genomics 1999)
    2. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Regulation of hyaluronidase activity by alternative mRNA splicing. (PubMed id 12084718)1, 2 Lokeshwar V.B.... Iida N. (J. Biol. Chem. 2002)
    5. Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines. (PubMed id 12684632)1, 9 Junker N....Kristjansen P.E. (Oncol. Rep. 2003)
    6. Expression of hyaluronan synthases and hyaluronidases in the MG63 osteoblast cell line. (PubMed id 16203124)1, 9 Adams J.R....Byers S. (Matrix Biol. 2006)
    7. Analysis of HYAL3 gene mutations in Chinese lung squamous cell carcinoma patients. (PubMed id 23549009)1 Zhang R.X....Ji X.Q. (Tumori 2013)
    8. Genetic association and gene-gene interaction of HAS2, HABP1 and HYAL3 implicate hyaluronan metabolic genes in glaucomatous neurodegeneration. (PubMed id 22960332)1 Basu K....Mukhopadhyay A. (Dis. Markers 2012)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Nodular basal cell carcinoma is associated with increased hyaluronan homeostasis. (PubMed id 20849445)1 Tzellos T.G....Papakonstantinou E. (J Eur Acad Dermatol Venereol 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8372 HGNC: 5322 AceView: HYAL3 Ensembl:ENSG00000186792 euGenes: HUgn8372
    ECgene: HYAL3 Kegg: 8372 H-InvDB: HYAL3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HYAL3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HYAL3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HYAL3 gene:
    Search GeneIP for patents involving HYAL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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