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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HYAL3 Gene

protein-coding GIFtS: 56
GCID: GC03M050331

hyaluronoglucosaminidase 3

Explore 10 diseases affiliated with
HYAL3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Hyaluronoglucosaminidase 3¹ ²		Minna14¹
LUCA3² ³ ⁵		HYAL-3²
LUCA-3¹ ²		Hyaluronidase-3¹
Lung Carcinoma Protein 3² ³		Hyal-3³
EC 3.2.1.35³ ⁸		Hyaluronoglucosaminidase-3³
LUCA14¹		LuCa-3³

External Ids:	HGNC: 5322¹	Entrez Gene: 8372²	Ensembl: ENSG00000186792⁷	OMIM: 604038⁵	UniProtKB: O43820³

Export aliases for HYAL3 gene to outside databases

Previous GC identifers: GC03P049651 GC03P049819 GC03M050179 GC03M050284 GC03M050301 GC03M050305

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HYAL3:

This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade

hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan

plays a critical role in many biological processes including cell proliferation, migration and differentiation. The

encoded protein may also play an important role in sperm function. This gene is one of several related genes in a

region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may

be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed

for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as

N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon. (provided

by RefSeq, Jan 2011)

Gene Wiki entry for HYAL3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HYAL3 gene promoter:
ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HYAL3 promoter sequence

Search SABiosciences Chromatin IP Primers for HYAL3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HYAL3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.3

HYAL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HYAL3 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M050331: view genomic region (about GC identifiers)

Start:	50,330,262 bp from pter	End:	50,336,899 bp from pter
Size:	6,638 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HYAL3_HUMAN, O43820 (See protein sequence)

Recommended Name: Hyaluronidase-3 precursor

Size: 417 amino acids; 46501 Da

Subcellular location: Secreted (By similarity). Lysosome (By similarity)

Sequence caution: Sequence=AAC70915.1; Type=Frameshift; Positions=410;

Secondary accessions: O60540 Q8NFK2 Q8NFK3 Q8NFK4 Q96E56 Q9BRW9

Alternative splicing: 4 isoforms: O43820-1 O43820-2 O43820-3 O43820-4 (Enzymatically inactive)

Explore the universe of human proteins at neXtProt for HYAL3: NX_O43820

4/9 DME Specific Peptides for HYAL3 (O43820) (see all 9)

LDPQEQL

GWAGPTC

PLWAGNWG

GVVLWGDLS

HYAL3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_001186958.1 NP_001186959.1 NP_001186960.1 NP_001186961.1 NP_003540.2

ENSEMBL proteins:

ENSP00000351946 ENSP00000337425 ENSP00000401092 ENSP00000424633 ENSP00000391663

ENSP00000391922

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	Uscn Proteins for HYAL3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005764	lysosome	IDA	16600643
GO:0031410	cytoplasmic vesicle	IDA	18390475

HYAL3 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HYAL3 for domains About GeneDecksing

5 InterPro domains/families:

IPR013785 Aldolase_TIM

IPR018155 Hyaluronidase

IPR000742 EG-like_dom

IPR017853 Glycoside_hydrolase_SF

IPR027260 Hyaluronidase-3

Graphical View of Domain Structure for InterPro Entry O43820

ProtoNet protein and cluster: O43820

2 Blocks protein families:

IPB001968 Glycosyl hydrolase family 56 signature

IPB006210 Type I EGF

UniProtKB/Swiss-Prot: HYAL3_HUMAN, O43820

Similarity: Belongs to the glycosyl hydrolase 56 family

Similarity: Contains 1 EGF-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HYAL3_HUMAN, O43820

Catalytic activity: Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues

in hyaluronate

Genatlas biochemistry entry for HYAL3:

hyaluroglucosaminidase 3,secreted in the sperm and involved in fertilization,involved in glycosaminoglycan catabolism

Enzyme Number (IUBMB): EC 3.2.1.35¹ ²

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		3 QIAGEN miScript miRNA Assays for microRNAs that regulate HYAL3:
		hsa-miR-3164 hsa-miR-1322 hsa-miR-1272
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HYAL3

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001618	NOT viral receptor activity	IDA	11296287
GO:0004415	NOT hyalurononglucosaminidase activity	IDA	17170110
GO:0033906	hyaluronoglucuronidase activity	IDA	--

HYAL3 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Glycosaminoglycan degradation

Glycosaminoglycan degradation

1.00

Metabolism

Metabolic pathways

0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Kegg Pathways (Kegg details for HYAL3):

	Glycosaminoglycan degradation
	Metabolic pathways

HYAL3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HYAL3

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/8 Interacting proteins for HYAL3 (ENSP00000337425⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARSB	ENSP00000264914⁴	STRING: ENSP00000264914
IDUA	ENSP00000247933⁴	STRING: ENSP00000247933
MCM10	ENSP00000354945⁴	STRING: ENSP00000354945
NBL1	ENSP00000289749⁴	STRING: ENSP00000289749
TARS2	ENSP00000358060⁴	STRING: ENSP00000358060

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	IEA	--
GO:0006954	inflammatory response	IDA	18390475
GO:0009615	response to virus	IDA	11296287
GO:0030214	hyaluronan catabolic process	IDA	12084718
GO:0046677	response to antibiotic	IEP	11944887

HYAL3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HYAL3
Search CenterWatch for drugs/clinical trials and news about HYAL3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HYAL3 gene (5 alternative transcripts):

NM_001200029.1 NM_001200030.1 NM_001200031.1 NM_001200032.1 NM_003549.3

Unigene Clusters for HYAL3:

Hyaluronoglucosaminidase 3

Hs.129910 [show with all ESTs], Hs.729310 [show with all ESTs]

Unigene Representative Sequences: NM_001200030, NM_003549

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000359051 ENST00000336307(uc021wyn.1 uc003cze.2 uc003czf.2 uc003czd.2 uc003czg.2)

ENST00000415204 ENST00000513170 ENST00000435141 ENST00000450982

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HYAL3
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		hsa-miR-3164 hsa-miR-1322 hsa-miR-1272
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Additional cDNA sequence:

AF036035.1 AF502910.1 AF502912.1 AK313455.1 BC005896.1 BC012892.1

11 DOTS entries:

DT.308846 DT.97831606 DT.111521 DT.100776985 DT.92421490 DT.100018143 DT.100776986 DT.97840361

DT.100689479 DT.70103718 DT.92421491

24/510 AceView cDNA sequences (see all 510):

NM_012191 AI003352 BM918332 BG057830 BM827282 BX283184 AA579404 CR613438

AW409968 AF502910 BE264254 BE328386 BM904960 CR621832 BE794146 BI821378

BE904712 BE563312 BM791438 AW960774 AI803247 CR590665 BM874367 CR594453

GeneLoc Exon Structure

5/27 Alternative Splicing Database (ASD) splice patterns (SP) for HYAL3 (see all 27) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	·	5d	·	5e	^	6	^	7a	·	7b	^	8	^	9	^	10a	·	10b	·	10c	^	11a	·	11b	·	11c	·
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	11d	·	11e	^	12a	·	12b	·	12c	^	13	^	14a	·	14b	^	15a	·	15b	·	15c	·	15d	·	15e	^	16a	·	16b	·	16c	·	16d	^	17	^	18a	·	18b	·	18c	^	19	^	20	^	21a	·	21b	^	22a	·
SP1:					-		-		-																-																				-		-
SP2:					-		-		-				-		-										-
SP3:																									-																				-		-
SP4:					-		-		-																-
SP5:																																													-		-

ExUns:	22b	^	23a	·	23b	·	23c	^	24a	·	24b
SP1:	-						-
SP2:
SP3:
SP4:
SP5:	-

ECgene alternative splicing isoforms for HYAL3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HYAL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGAGGTCAC

About this image

HYAL3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Cartilage

Autopod Articular Cartilage

Articular Cartilage Cells

Selective marker (cell-identifying gene)

Cartilage

Stylopod Articular Cartilage

Articular Cartilage Cells

Cartilage

Zeugopod Articular Cartilage

Articular Cartilage Cells

Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

See HYAL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HYAL3

SOURCE GeneReport for Unigene clusters: Hs.129910 Hs.729310

UniProtKB/Swiss-Prot: HYAL3_HUMAN, O43820

Tissue specificity: Bone marrow, testis and kidney. Isoform 4 is detected in all bladder tumor and prostate tumor cells

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HYAL3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HYAL3 gene from 5/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC100859903¹	hyaluronidase-3-like	62.4(n) 57.8(a)		100859903 XM_003641994.1 XP_003642042.1
lizard (Anolis carolinensis)	Reptilia	HYAL3⁶	--	54(a)	1 ↔ 1	2(149862657-149865825)
zebrafish (Danio rerio)	Actinopterygii	hyal3¹	hyaluronoglucosaminidase 3	50.87(n) 46.4(a)		100004557 NM_001128293.1 NP_001121765.1
honey bee (Apis mellifera)	Insecta	--	--	26(a)	1 → many	Group14.3(803059-805153)
worm (Caenorhabditis elegans)	Secernentea	T22C8.2³	hyaluronidase	29(a)		II(8614552-8617147) --

ENSEMBL Gene Tree for HYAL3 (if available)
TreeFam Gene Tree for HYAL3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HYAL3 gene

SPAM1² HYAL2² HYAL1² HYAL4²

6 SIMAP similar genes for HYAL3 using alignment to 3 protein entries: HYAL3_HUMAN (see all proteins):

NAT6 HYAL4 HYAL1 HYAL2 LOC402588 SPAM1

HYAL3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189065354^1,2	C,	--	50332228(+)	`CCACAC/TGGAAG`	10	H R	mis¹		0	--	--	--	--
rs147909273^1,2	C,F,	--	50332262(+)	`AAAGGC/TCTGGT`	10	T A	mis¹		1		NA	4550
rs141285629^1,2	C	--	50332355(+)	`GTTGCG/AGGCAA`	8	/R /C	int¹ mis¹		1		NA	4544
rs142315421^1,2	C,F	--	50332378(+)	`GGCAGC/TGGCCG`	8	H R	int¹ mis¹		1		NA	4532
rs149248362^1,2	C,	--	50332459(+)	`GGGGCC/TGTAGT`	8	Q R	mis¹ int¹		1		NA	4524
rs137937192^1,2	C	--	50332460(+)	`GGGCCG/ATAGTG`	8	/R /W	mis¹ int¹		1		NA	4522
rs139756596^1,2	C,F,	--	50332501(+)	`GTGCAC/TGGGCC`	8	H R	mis¹ int¹		2		NA EU	5555
rs201186184^1,2		--	50332554(+)	`GGGTCC/TAGGTC`	8	L	int¹ syn¹		0	--	--	--	--
rs200168148^1,2		--	50332571(+)	`TACCTA/GCTGTG`	8	Q *	stg¹ int¹		0	--	--	--	--
rs146737984^1,2	C,	--	50332606(+)	`AAGCTC/TGGCGG`	8	Q R	int¹ mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HYAL3 (50330262 - 50336899 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for HYAL3
4 CNVs: 30176 4335 3429 4336

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QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HYAL3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HYAL3 for disorders           About GeneDecksing

OMIM gene information: 604038    OMIM disorders: --

10 diseases for HYAL3:    About MalaCards

lung carcinoma mucopolysaccharidosis type ix nodular basal cell carcinoma basal cell carcinoma

carcinoma mucopolysaccharidosis colorectal cancer lung cancer

prostate cancer prostatitis

1 Novoseek disease relationship for HYAL3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	3	11802201 (3)

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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HYAL3 gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with HYAL3)

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Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31. (PubMed id 10493834)^{1, 2, 3} Csoka A.B.... Stern R. (1999)
The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)^{1, 2} Muzny D.M....Gibbs R.A. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Regulation of hyaluronidase activity by alternative mRNA splicing. (PubMed id 12084718)^{1, 2} Lokeshwar V.B.... Iida N. (2002)
Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines. (PubMed id 12684632)^{1, 9} Junker N....Kristjansen P.E. (2003)
Expression of hyaluronan synthases and hyaluronidases in the MG63 osteoblast cell line. (PubMed id 16203124)^{1, 9} Adams J.R....Byers S. (2006)
Genetic association and gene-gene interaction of HAS2, HABP1 and HYAL3 implicate hyaluronan metabolic genes in glaucomatous neurodegen eration. (PubMed id 22960332)¹ Basu K....Mukhopadhyay A. (2012)
Involvement of hyaluronidases in colorectal cancer. (PubMed id 20849597)¹ Bouga H....Vynios D.H. (2010)
Acidic hyaluronidase activity is present in mouse spe rm and is reduced in the absence of SPAM1: evidence for a role for hyaluronidas e 3 in mouse and human sperm. (PubMed id 20586096)¹ Reese K.L....Martin-Deleon P.A. (2010)
Nodular basal cell carcinoma is associated with incre ased hyaluronan homeostasis. (PubMed id 20849445)¹ Tzellos T....Papakonstantinou E. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8372	HGNC: 5322	AceView: HYAL3	Ensembl:ENSG00000186792	euGenes: HUgn8372
ECgene: HYAL3	Kegg: 8372	H-InvDB: HYAL3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HYAL3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HYAL3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for HYAL3 gene
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Patent Information for HYAL3 gene:
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hyaluronoglucosaminidase 3

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hyaluronoglucosaminidase 3

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