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Aliases for HYAL2 Gene

Aliases for HYAL2 Gene

  • Hyaluronoglucosaminidase 2 2 3
  • LUCA2 3 4 6
  • Hyaluronoglucosaminidase-2 3 4
  • Lung Carcinoma Protein 2 3 4
  • Lysosomal Hyaluronidase 2 3
  • Hyaluronidase 2 2 3
  • PH-20 Homolog 2 3
  • EC 4 63
  • Hyal-2 3 4
  • Hyaluronidase-2 3
  • PH20 Homolog 3
  • LuCa-2 4

External Ids for HYAL2 Gene

Previous GeneCards Identifiers for HYAL2 Gene

  • GC03P049626
  • GC03P049796
  • GC03M050209
  • GC03M050314
  • GC03M050330
  • GC03M050355

Summaries for HYAL2 Gene

Entrez Gene Summary for HYAL2 Gene

  • This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.[provided by RefSeq, Mar 2010]

GeneCards Summary for HYAL2 Gene

HYAL2 (Hyaluronoglucosaminidase 2) is a Protein Coding gene. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include enzyme binding and receptor tyrosine kinase binding. An important paralog of this gene is HYAL3.

UniProtKB/Swiss-Prot for HYAL2 Gene

  • Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.

Gene Wiki entry for HYAL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HYAL2 Gene

Genomics for HYAL2 Gene

Regulatory Elements for HYAL2 Gene

Transcription factor binding sites by QIAGEN in the HYAL2 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HYAL2 Gene

50,317,790 bp from pter
50,322,906 bp from pter
5,117 bases
Minus strand

Genomic View for HYAL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HYAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HYAL2 Gene

Proteins for HYAL2 Gene

  • Protein details for HYAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B3KRZ2
    • O15177
    • Q9BW29

    Protein attributes for HYAL2 Gene

    473 amino acids
    Molecular mass:
    53860 Da
    Quaternary structure:
    • Interacts with MST1R.
    • Sequence=AAC28656.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for HYAL2 Gene

Proteomics data for HYAL2 Gene at MOPED

Post-translational modifications for HYAL2 Gene

  • Glycosylation at Asn74, Asn103, and Asn357
  • Modification sites at PhosphoSitePlus

Other Protein References for HYAL2 Gene

Domains for HYAL2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q12891
  • Contains 1 EGF-like domain.
  • Belongs to the glycosyl hydrolase 56 family.
genes like me logo Genes that share domains with HYAL2: view

No data available for Gene Families for HYAL2 Gene

Function for HYAL2 Gene

Molecular function for HYAL2 Gene

GENATLAS Biochemistry: hyaluroglucosaminidase 2,lysosomal,ubiquitously expressed,but not in adult brain,related to testicular SPAM1,involved in glycosaminoglycan catabolism
UniProtKB/Swiss-Prot CatalyticActivity: Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate
UniProtKB/Swiss-Prot Function: Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.

Enzyme Numbers (IUBMB) for HYAL2 Gene

Gene Ontology (GO) - Molecular Function for HYAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IDA 11296287
GO:0004415 hyalurononglucosaminidase activity TAS --
GO:0005515 protein binding IPI 12676986
GO:0005540 hyaluronic acid binding IDA 12676986
GO:0019899 enzyme binding IPI 19366691
genes like me logo Genes that share ontologies with HYAL2: view
genes like me logo Genes that share phenotypes with HYAL2: view

Animal Models for HYAL2 Gene

MGI Knock Outs for HYAL2:

Animal Model Products

CRISPR Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for HYAL2 Gene

Localization for HYAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HYAL2 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Jensen Localization Image for HYAL2 Gene COMPARTMENTS Subcellular localization image for HYAL2 gene
Compartment Confidence
endoplasmic reticulum 5
lysosome 5
plasma membrane 5
vacuole 5
cytosol 4
golgi apparatus 4
extracellular 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HYAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane ISS 21740893
GO:0005737 cytoplasm IDA 17170110
GO:0005764 lysosome IDA 16600643
GO:0005783 endoplasmic reticulum NAS 16191204
GO:0005829 cytosol IDA 19366691
genes like me logo Genes that share ontologies with HYAL2: view

Pathways for HYAL2 Gene

genes like me logo Genes that share pathways with HYAL2: view

Pathways by source for HYAL2 Gene

Interacting Proteins for HYAL2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000350387 Q12891-HYAL2_HUMAN for HYAL2 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for HYAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species IDA 20554532
GO:0001822 kidney development ISS --
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006027 glycosaminoglycan catabolic process IDA 9712871
genes like me logo Genes that share ontologies with HYAL2: view

Compounds for HYAL2 Gene

(3) HMDB Compounds for HYAL2 Gene

Compound Synonyms Cas Number PubMed IDs
  • 2-Acetamido-2-desoxy-b-D-talofuranose
N-Acetylgalactosamine 4-sulphate
  • N-Acetyl-D-galactosamine 4-sulfate
  • Dihydrogen oxide

(4) Novoseek inferred chemical compound relationships for HYAL2 Gene

Compound -log(P) Hits PubMed IDs
hyaluronic acid 49.2 2
tyrosine 9.76 4
phosphatidylinositol 7.59 1
lipid 0 1
genes like me logo Genes that share compounds with HYAL2: view

Transcripts for HYAL2 Gene

Unigene Clusters for HYAL2 Gene

Hyaluronoglucosaminidase 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HYAL2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HYAL2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6
SP1: - - - -
SP2: - - - - - -
SP3: - - - - -
SP5: -

Relevant External Links for HYAL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HYAL2 Gene

mRNA expression in normal human tissues for HYAL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HYAL2 Gene

This gene is overexpressed in Spleen (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for HYAL2 Gene

SOURCE GeneReport for Unigene cluster for HYAL2 Gene Hs.76873

mRNA Expression by UniProt/SwissProt for HYAL2 Gene

Tissue specificity: Widely expressed. No expression detected in adult brain.
genes like me logo Genes that share expressions with HYAL2: view

In Situ Assay Products

Orthologs for HYAL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HYAL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HYAL2 35
  • 99.3 (n)
  • 99.58 (a)
HYAL2 36
  • 100 (a)
(Bos Taurus)
Mammalia HYAL2 35
  • 85.74 (n)
  • 86.17 (a)
HYAL2 36
  • 86 (a)
(Canis familiaris)
Mammalia HYAL2 35
  • 86.62 (n)
  • 89.17 (a)
HYAL2 36
  • 88 (a)
(Mus musculus)
Mammalia Hyal2 35
  • 83.37 (n)
  • 82.03 (a)
Hyal2 16
Hyal2 36
  • 82 (a)
(Monodelphis domestica)
Mammalia HYAL2 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia HYAL2 36
  • 63 (a)
(Rattus norvegicus)
Mammalia Hyal2 35
  • 82.59 (n)
  • 82.03 (a)
(Gallus gallus)
Aves HYAL2 35
  • 65.37 (n)
  • 58.68 (a)
HYAL2 36
  • 54 (a)
(Anolis carolinensis)
Reptilia HYAL2 36
  • 56 (a)
African clawed frog
(Xenopus laevis)
Amphibia hyal2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia hyal2 35
  • 63.04 (n)
  • 60.52 (a)
Str.14988 35
(Danio rerio)
Actinopterygii hyal2 35
  • 57.27 (n)
  • 50.95 (a)
hyal2 36
  • 44 (a)
HYAL2 (1 of 3) 36
  • 46 (a)
HYAL2 (3 of 3) 36
  • 46 (a)
(Caenorhabditis elegans)
Secernentea chhy-1 36
  • 26 (a)
T22C8.2 37
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for HYAL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HYAL2 Gene

Gene Tree for HYAL2 (if available)
Gene Tree for HYAL2 (if available)

Paralogs for HYAL2 Gene

Paralogs for HYAL2 Gene

Selected SIMAP similar genes for HYAL2 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with HYAL2: view

Variants for HYAL2 Gene

Sequence variations from dbSNP and Humsavar for HYAL2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs14352 -- 50,318,069(-) GGCAT(A/G/T)TAGGA utr-variant-3-prime
rs709210 - 50,320,438(-) CGGTG(G/T)CATGG missense, reference
rs755417 -- 50,320,504(-) CACCT(C/G)CTGCA utr-variant-5-prime
rs1050072 -- 50,320,499(-) CCTGC(A/C)GCCCC utr-variant-5-prime
rs1050073 -- 50,319,709(-) CTTCC(G/T)CCCGC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for HYAL2 Gene

Variant ID Type Subtype PubMed ID
nsv523662 CNV Loss 19592680
nsv876769 CNV Loss 21882294
nsv470561 CNV Loss 18288195
nsv876770 CNV Loss 21882294
dgv1456e1 CNV Complex 17122850
nsv834692 CNV Loss 17160897
nsv460531 CNV Loss 19166990
dgv5131n71 CNV Loss 21882294
dgv5132n71 CNV Loss 21882294
nsv834693 CNV Loss 17160897
nsv3813 CNV Loss 18451855
dgv5133n71 CNV Loss 21882294

Relevant External Links for HYAL2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HYAL2 Gene

Disorders for HYAL2 Gene

(9) Novoseek inferred disease relationships for HYAL2 Gene

Disease -log(P) Hits PubMed IDs
jaagsiekte 95.5 13
carcinoma bronchioloalveolar 49.5 2
tumors 31.8 19
cancer lung 30.7 3
breast cancer 11.4 4

Relevant External Links for HYAL2

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HYAL2: view

No data available for UniProtKB/Swiss-Prot for HYAL2 Gene

Publications for HYAL2 Gene

  1. HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity. (PMID: 9712871) Lepperdinger G. … Kreil G. (J. Biol. Chem. 1998) 2 3 4 23
  2. Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidase. (PMID: 9790770) Strobl B. … Lepperdinger G. (Genomics 1998) 2 3 23
  3. Hyal2 -- less active, but more versatile? (PMID: 11731268) Lepperdinger G. … Kreil G. (Matrix Biol. 2001) 3 4 23
  4. Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus. (PMID: 12676986) Danilkovitch-Miagkova A. … Lerman M.I. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 23
  5. Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation. (PMID: 11296287) Rai S.K. … Miller A.D. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4 23

Products for HYAL2 Gene

Sources for HYAL2 Gene

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