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HVCN1 Gene

protein-coding   GIFtS: 50
GCID: GC12M111086

Hydrogen Voltage-Gated Channel 1

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hydrogen Voltage-Gated Channel 11 2 3
Voltage Sensor Domain-Only Protein1 2 3
HV12 3 5
VSOP2 3 5
Voltage-Gated Hydrogen Channel 12

External Ids:    HGNC: 282401   Entrez Gene: 843292   Ensembl: ENSG000001229867   OMIM: 6112275   UniProtKB: Q96D963   

Export aliases for HVCN1 gene to outside databases

Previous GC identifers: GC12M109570 GC12M108104


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HVCN1 Gene:
This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune
system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same
process facilitates antibody production. This same channel protein, however, can also regulate functions in other
cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for HVCN1 Gene:
HVCN1 (hydrogen voltage-gated channel 1) is a protein-coding gene. Diseases associated with HVCN1 include breast cancer. GO annotations related to this gene include voltage-gated proton channel activity and voltage-gated cation channel activity. An important paralog of this gene is C15orf27.

UniProtKB/Swiss-Prot: HVCN1_HUMAN, Q96D96
Function: Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective
channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux,
accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis

Gene Wiki entry for HVCN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HVCN1 gene promoter:
         FOXI1   HFH-3   RFX1   Nkx6-1   FOXD3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HVCN1 promoter sequence
   Search Chromatin IP Primers for HVCN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HVCN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.11   Ensembl cytogenetic band:  12q24.11   HGNC cytogenetic band: 12q24.11

HVCN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HVCN1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M111086:  view genomic region     (about GC identifiers)

Start:
111,065,646 bp from pter      End:
111,142,755 bp from pter
Size:
77,110 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HVCN1_HUMAN, Q96D96 (See protein sequence)
Recommended Name: Voltage-gated hydrogen channel 1  
Size: 273 amino acids; 31683 Da
Subunit: Homodimer
Sequence caution: Sequence=AAQ89413.1; Type=Frameshift; Positions=164, 175;
1 PDB 3D structure from and Proteopedia for HVCN1:
3A2A (3D)    
Secondary accessions: A8MQ37 B4DEB3 F8WCH5 Q6UW11 Q96IS5
Alternative splicing: 4 isoforms:  Q96D96-1   Q96D96-2   Q96D96-3   Q96D96-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HVCN1: NX_Q96D96

Explore proteomics data for HVCN1 at MOPED

Post-translational modifications: 

  • Phosphorylation may enhance channel gating1
  • Ubiquitination2 at Lys7
  • Modification sites at PhosphoSitePlus

  • See HVCN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001035196.1  NP_001243342.1  NP_115745.2  

    ENSEMBL proteins: 
     ENSP00000449601   ENSP00000242607   ENSP00000349181   ENSP00000412052   ENSP00000450106  
     ENSP00000448379   ENSP00000447227  
    Reactome Protein details: Q96D96

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HVCN: Voltage-gated ion channels / Hydrogen voltage-gated channel

    IUPHAR Guide to PHARMACOLOGY protein family classification: Hv1
    Voltage-gated proton channel

    2 InterPro protein domains:
     IPR005821 Ion_trans_dom
     IPR027359 Channel_four-helix_dom

    Graphical View of Domain Structure for InterPro Entry Q96D96

    ProtoNet protein and cluster: Q96D96

    UniProtKB/Swiss-Prot: HVCN1_HUMAN, Q96D96
    Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino
    acids at every third position. Unlike other voltage-gated ion channels it lacks the pore domain
    Domain: The C-terminal coiled coil region mediates homodimerization and cooperative channel gating. It is
    essential for normal subcellular localization
    Similarity: Belongs to the hydrogen channel family


    HVCN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HVCN1_HUMAN, Q96D96
    Function: Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective
    channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux,
    accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis
    Enzyme regulation: The dimers display cooperative channel gating (By similarity). The channel activity is
    inhibited by zinc ions

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0022843voltage-gated cation channel activity TAS--
    GO:0030171voltage-gated proton channel activity ISS16556803
         
    HVCN1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hvcn1):
     hematopoietic system  immune system 

    HVCN1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HVCN1
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    hsa-miR-3934 hsa-miR-125a-3p hsa-miR-513a-3p hsa-let-7a-2* hsa-miR-764 hsa-miR-493* hsa-miR-1207-3p hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidHVCN1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HVCN1_HUMAN, Q96D96: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
    Note=Detected mainly at intracellular membranes upon overexpression in HeLa cells (PuMed:20147290), but not in
    other cell types
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    plasma membrane3
    peroxisome2
    cytosol1
    golgi apparatus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IDA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IDA16554753

    HVCN1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HVCN1 About    
    See pathways by source

    SuperPathContained pathways About
    1Reproduction
    Reproduction1.00
    Sperm Motility And Taxes0.00
    Fertilization1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for HVCN1
        Sperm Motility And Taxes



    HVCN1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HVCN1
    Interactions:

        Search GeneGlobe Interaction Network for HVCN1

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0007338single fertilization TAS--
    GO:0009268response to pH ISS16556803
    GO:0010043response to zinc ion ISS16556803
    GO:0015992proton transport ISS16556803

    HVCN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for HVCN1

    1 HMDB Compound for HVCN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    HydrogenHydrogen cation (see all 7)1333-74-0--

    2 IUPHAR Ligands for HVCN1 (Hv1)    About this table
    LigandTypeActionAffinityPubmed IDs
    Zn2+
    Channel blockerNone5.7 - 6.3--
    Cd2+
    Channel blockerNone5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HVCN1 gene (3 alternative transcripts): 
    NM_001040107.1  NM_001256413.1  NM_032369.3  

    Unigene Cluster for HVCN1:

    Hydrogen voltage-gated channel 1
    Hs.334637  [show with all ESTs]
    Unigene Representative Sequence: BC032672
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000548312(uc001trq.1) ENST00000242607(uc001trs.1 uc001trt.1 uc010syd.1)
    ENST00000356742 ENST00000439744 ENST00000549442 ENST00000547887 ENST00000546713
    ENST00000546425
    miRNA
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    hsa-miR-3934 hsa-miR-125a-3p hsa-miR-513a-3p hsa-let-7a-2* hsa-miR-764 hsa-miR-493* hsa-miR-1207-3p hsa-let-7g*
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      QuantiFast Probe-based Assays in human, mouse, rat HVCN1

    Additional mRNA sequence: 

    AK293543.1 BC007277.1 BC009731.1 BC032672.2 GU211002.1 

    9 DOTS entries:

    DT.95171711  DT.100029442  DT.218115  DT.97799234  DT.100010992  DT.100029446  DT.91969652  DT.95171712 
    DT.95353702 

    Selected AceView cDNA sequences (see all 107):

    BP375483 AI439493 BU899218 BQ052657 AW075771 BF941832 AI624251 AA251601 
    BP340417 AI364713 AA831648 AA807519 AI819639 CR596429 AA902810 BQ020897 
    CD672803 AI433364 BC007277 BX103110 BM476403 BQ069060 BQ707764 NM_032369 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HVCN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAACACTT
    HVCN1 Expression
    About this image


    HVCN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
    HVCN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HVCN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.334637

    UniProtKB/Swiss-Prot: HVCN1_HUMAN, Q96D96
    Tissue specificity: Enriched in immune tissues, such as lymph nodes, B-lymphocytes, monocytes and spleen

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HVCN1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hvcn11 , 5 hydrogen voltage-gated channel 11, 5 79.93(n)1
    78.81(a)1
      5 (62.23 cM)5
    740961  NM_028752.31  NP_083028.11 
     1222068045 
    chicken
    (Gallus gallus)
    Aves HVCN11 hydrogen voltage-gated channel 1 66.95(n)
    62.23(a)
      416871  NM_001030663.1  NP_001025834.1 
    lizard
    (Anolis carolinensis)
    Reptilia HVCN16
    hydrogen voltage-gated channel 1
    61(a)
    1 ↔ 1
    GL343423.1(373378-376520)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hvcn11 hydrogen voltage-gated channel 1 58.89(n)
    54.71(a)
      496712  NM_001011262.1  NP_001011262.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hvcn11 hydrogen voltage-gated channel 1 52.65(n)
    46.78(a)
      436618  NM_001002346.1  NP_001002346.1 


    ENSEMBL Gene Tree for HVCN1 (if available)
    TreeFam Gene Tree for HVCN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HVCN1 gene
    C15orf272  

    HVCN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HVCN1 (see all 682)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1433811831,2
    C--111087502(+) GCCCTA/GGGATG 3 -- int10--------
    rs1123409951,2
    F--111087655(+) CAGATG/ATCTTT 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs1914692871,2
    --111087668(+) TTTTTA/GAGACA 3 -- int10--------
    rs2011882041,2
    C--111087957(+) CAGATG/TTGTCG 3 -- int10--------
    rs1112773151,2
    C--111087971(+) TTCTTT/ACCTTC 3 -- spd11Minor allele frequency- A:0.00CSA 1
    rs2013139631,2
    C,F--111087984(+) AGAGCA/CGCTGA 6 G C mis11Minor allele frequency- C:0.00EU 1323
    rs1405506781,2
    C,F--111088036(+) TGTTTT/AAACCT 6 /L /F mis11Minor allele frequency- A:0.00NA 4550
    rs1452253881,2
    C--111088061(+) CTGAAC/TGTGTC 6 H R mis11Minor allele frequency- T:0.00NA 4546
    rs1886718521,2
    --111088233(+) GGGAGA/GTCAGG 3 -- int10--------
    rs731918541,2
    --111088439(+) TCCCCA/GTAACA 3 -- int10--------

    HapMap Linkage Disequilibrium report for HVCN1 (111065646 - 111142755 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HVCN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2746356CNV Deletion23290073

    Human Gene Mutation Database (HGMD): HVCN1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HVCN1
    DNA2.0 Custom Variant and Variant Library Synthesis for HVCN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611227    OMIM disorders: --

    1 disease for HVCN1:    
    About MalaCards
    breast cancer


    HVCN1 for disorders           About GeneDecksing


    Export disorders for HVCN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HVCN1 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with HVCN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Aspartatea88112 is the selectivity filter of the human voltage-gated proton channel. (PubMed id 22020278)1, 2, 3 Musset B....Decoursey T.E. (Nature 2011)
    2. pH regulation and beyond: unanticipated functions for the voltage-gated proton channel, HVCN1. (PubMed id 20961760)1, 3 Capasso M....Dyer M.J. (Trends Cell Biol. 2011)
    3. Identification of Thr29 as a critical phosphorylation site that activates the human proton channel Hvcn1 in leukocytes. (PubMed id 20037153)1, 2 Musset B....DeCoursey T.E. (J. Biol. Chem. 2010)
    4. The role and structure of the carboxyl-terminal domain of the human voltage-gated proton channel Hv1. (PubMed id 20147290)1, 2 Li S.J.... Sun F. (J. Biol. Chem. 2010)
    5. Detailed comparison of expressed and native voltage-gated proton channel currents. (PubMed id 18356202)1, 3 Musset B....DeCoursey T.E. (J. Physiol. (Lond.) 2008)
    6. A voltage sensor-domain protein is a voltage-gated proton channel. (PubMed id 16556803)1, 3 Sasaki M....Okamura Y. (Science 2006)
    7. A voltage-gated proton-selective channel lacking the pore domain. (PubMed id 16554753)1, 2 Ramsey I.S.... Clapham D.E. (Nature 2006)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    9. Hydrophobic plug functions as a gate in voltage-gated proton channels. (PubMed id 24379371)1 Chamberlin A....Larsson H.P. (Proc. Natl. Acad. Sci. U.S.A. 2014)
    10. Human voltage-gated proton channel hv1: a new potential biomarker for diagnosis and prognosis of colorectal cancer. (PubMed id 23940591)1 Wang Y....Li S.J. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84329 HGNC: 28240 AceView: MGC15619 Ensembl:ENSG00000122986 euGenes: HUgn84329
    ECgene: HVCN1 H-InvDB: HVCN1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HVCN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HVCN1 gene:
    Search GeneIP for patents involving HVCN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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