HVCN1 Gene
protein-coding GIFtS: 44
GCID: GC12M111086
|
|
hydrogen voltage-gated channel 1
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Aliases
for HVCN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Hydrogen Voltage-Gated Channel 11 2 3 | | Hv11 | | VSOP1 2 3 | | MGC156191 | | Voltage Sensor Domain-Only Protein2 3 | | Voltage-Gated Hydrogen Channel 12 | | HV12 3 | | |
Export aliases for HVCN1 gene to outside databasesPrevious GC identifers: GC12M109570 GC12M108104 |
Summaries
for HVCN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HVCN1:
This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system.Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same processfacilitates antibody production. This same channel protein, however, can also regulate functions in other cellsincluding spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Jan 2012)
UniProtKB/Swiss-Prot: HVCN1_HUMAN, Q96D96Function: Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channelthrough which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied bymembrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis
Gene Wiki entry for HVCN1
|
Genomic Views
for HVCN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009775.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HVCN1 gene promoter:
FOXI1 HFH-3 RFX1 Nkx6-1 FOXD3
Other transcription factors
Search SABiosciences Chromatin IP Primers for HVCN1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HVCN1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.11 Ensembl cytogenetic band: 12q24.11 HGNC cytogenetic band: 12q24.11HVCN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M111086: view genomic region
(about GC identifiers)
Start:
|
111,065,646 bp from pter |
End:
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111,142,755 bp from pter |
Size:
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77,110 bases |
Orientation:
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minus strand |
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Proteins
for HVCN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HVCN1_HUMAN, Q96D96 (See
protein sequence)Recommended Name: Voltage-gated hydrogen channel 1 Size: 273 amino acids; 31683 Da
Subunit: Homodimer
Subcellular location: Membrane; Multi-pass membrane protein. Note=Associates mainly with intracellular compartmentmembranes
Sequence caution: Sequence=AAQ89413.1; Type=Frameshift; Positions=164, 175;
1 PDB 3D structure from  and Proteopedia  for HVCN1:3A2A (3D)
Secondary accessions: A8MQ37 B4DEB3 F8WCH5 Q6UW11 Q96IS5Alternative splicing: 4 isoforms: Q96D96-1 Q96D96-2 Q96D96-3 Q96D96-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for HVCN1: NX_Q96D96
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96D96
HVCN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001035196.1 NP_001243342.1 NP_115745.2
ENSEMBL proteins: ENSP00000449601 ENSP00000242607 ENSP00000349181 ENSP00000412052 ENSP00000450106 ENSP00000448379 ENSP00000447227
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
HVCN1 for ontologies About GeneDecksing
HVCN1 Antibody Products:
Assay Products for HVCN1: |
Protein
Domains /
Families
for HVCN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HVCN1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96D96ProtoNet protein and cluster: Q96D96 UniProtKB/Swiss-Prot: HVCN1_HUMAN, Q96D96Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged aminoacids at every third position. Unlike other voltage-gated ion channels it lacks the pore domainDomain: The C-terminal coiled coil region mediates homodimerization and is essential for localizationSimilarity: Belongs to the hydrogen channel family |
Function
for HVCN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HVCN1_HUMAN, Q96D96Function: Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channelthrough which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied bymembrane depolarization, facilitates acute production of reactive oxygen species in phagocytosisEnzyme regulation: Sensitive to zinc ions and is inhibited by them
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HVCN1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for HVCN1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HVCN1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HVCN1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0030171 | voltage-gated proton channel activity |
ISS | 16556803 |
HVCN1 for ontologies About GeneDecksing
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Hvcn1):
HVCN1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for HVCN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HVCN1
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
HVCN1 for ontologies About GeneDecksing
|
Drugs & Compounds
for HVCN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HVCN1
1 HMDB Compound for HVCN1 About this table
Search CenterWatch for drugs/clinical trials and news about HVCN1
|
Transcripts
for HVCN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HVCN1 gene (3 alternative transcripts): NM_001040107.1 NM_001256413.1 NM_032369.3 Unigene Cluster for HVCN1: Hydrogen voltage-gated channel 1 Hs.334637 [show with all ESTs]Unigene Representative Sequence: BC0326728 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000548312(uc001trq.1) ENST00000242607(uc001trs.1 uc001trt.1 uc010syd.1)
ENST00000356742 ENST00000439744 ENST00000549442 ENST00000547887 ENST00000546713
ENST00000546425
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HVCN1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HVCN1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): HVCN1 (NM_001040107) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HVCN1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HVCN1 |
Additional cDNA sequence: AK293543.1 BC007277.1 BC009731.1 BC032672.2 GU211002.1 9 DOTS entries: DT.95171711 DT.100029442 DT.218115 DT.97799234 DT.100010992 DT.100029446 DT.91969652 DT.95171712 DT.95353702 24/107 AceView cDNA sequences (see all 107): AI364713 BI834245 AI624251 BQ020897 AI439493 BQ069060 BM543473 BC032672 AA902810 AA807519 AA831648 BC007277 BQ707764 BQ052657 NM_032369 BX103110 CR596429 AI936701 BP340417 BM564174 AA251601 BM476403 AI819639 BC009731
GeneLoc Exon Structure
|
Expression
for HVCN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HVCN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGAACACTT
About this image
See HVCN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HVCN1
SOURCE GeneReport for Unigene cluster: Hs.334637
UniProtKB/Swiss-Prot: HVCN1_HUMAN, Q96D96Tissue specificity: Enriched in immune tissues, such as lymph nodes, B-lymphocytes, monocytes and spleen
SABiosciences Custom PCR Arrays for HVCN1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HVCN1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HVCN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HVCN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HVCN1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HVCN1 |
Orthologs
for HVCN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HVCN1 gene from 3/13 species (see all 13) About this table
ENSEMBL Gene Tree for HVCN1 (if available)
TreeFam Gene Tree for HVCN1 (if available) |
Paralogs
for HVCN1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HVCN1 gene
- C15orf272
HVCN1 for paralogs About GeneDecksing
|
Genomic Variants
for HVCN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HVCN1 (111065646 - 111142755 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HVCN1: --
Human Gene Mutation Database (HGMD): HVCN1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HVCN1 |
|
Disorders
/ Diseases
for HVCN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HVCN1 for disorders About GeneDecksing
OMIM gene information: 611227
OMIM disorders: --
1  disease for HVCN1: About MalaCardsbreast cancer
Export disorders for HVCN1 gene to outside databases
|
Publications
for HVCN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HVCN1 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with HVCN1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Aspartatea88112 is the selectivity filter of the human voltage-gated proton channel. (PubMed id 22020278)1, 3 Musset B....Decoursey T.E. (2011)
- pH regulation and beyond: unanticipated functions for the voltage-gated proton channel, HVCN1. (PubMed id 20961760)1, 3 Capasso M....Dyer M.J. (2011)
- The role and structure of the carboxyl-terminal domai n of the human voltage-gated proton channel Hv1. (PubMed id 20147290)1, 2 Li S.J....Sun F. (2010)
- Detailed comparison of expressed and native voltage-gated proton channel currents. (PubMed id 18356202)1, 3 Musset B....DeCoursey T.E. (2008)
- A voltage sensor-domain protein is a voltage-gated proton channel. (PubMed id 16556803)1, 3 Sasaki M....Okamura Y. (2006)
- A voltage-gated proton-selective channel lacking the pore domain. (PubMed id 16554753)1, 2 Ramsey I.S.... Clapham D.E. (2006)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Clinicopathological and biological significance of hum an voltage-gated proton channel Hv1 protein overexpression in breast cancer. (PubMed id 22367212)1 Wang Y....Li Q. (2012)
- Do Hv1 proton channels regulate the ionic and redox ho meostasis of phagosomes? (PubMed id 22056415)1 El Chemaly A. and Demaurex N. (2012)
- The voltage-gated proton channel Hv1 enhances brain da mage from ischemic stroke. (PubMed id 22388960)1 Wu L.J....Clapham D.E. (2012)
|
External Searches for HVCN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HVCN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HVCN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HVCN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HVCN1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HVCN1 gene:
Search GeneIP for patents involving HVCN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HVCN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HVCN1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HVCN1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HVCN1 | | | OriGene Protein Over-expression Lysate for HVCN1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HVCN1 | | OriGene 3'-UTR Clone for HVCN1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HVCN1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HVCN1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HVCN1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HVCN1 | | OriGene Custom Protein Services for HVCN1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HVCN1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HVCN1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HVCN1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HVCN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HVCN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HVCN1 |
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| | | | Search Tocris compounds for HVCN1 |
| |  |  |  |  | | | | |
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 | | | HVCN1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HVCN1 |
|  |  |  | | | | ThermoFisher Antibodies for HVCN1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HVCN1 |
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