HUS1B Gene
protein-coding GIFtS: 48
GCID: GC06M000655
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HUS1 checkpoint homolog b (S. pombe)(Previous name: HUS1 (S. pombe) checkpoint homolog b )
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Aliases
for HUS1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| HUS1 Checkpoint Homolog B (S. Pombe)1 2 | | HHUS1B1 | | HUS1 (S. Pombe) Checkpoint Homolog B1 | | RP11-532F6.12 | | Checkpoint Protein HUS1B2 |
Export aliases for HUS1B gene to outside databasesPrevious GC identifers: GC06M000646 GC06M000600 |
Summaries
for HUS1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HUS1B:
The protein encoded by this gene is most closely related to HUS1, a component of a cell cycle checkpoint proteincomplex involved in cell cycle arrest in response to DNA damage. This protein can interact with the check pointprotein RAD1 but not with RAD9. Overexpression of this protein has been shown to induce cell death, which suggests arelated but distinct role of this protein, as compared to the HUS1. (provided by RefSeq, Jul 2008)
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Genomic Views
for HUS1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HUS1B gene promoter:
GR Tal-1 C/EBPalpha MEF-2A E2F E2F-1 FOXO1a aMEF-2 GR-alpha FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HUS1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HUS1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p25.3 Ensembl cytogenetic band: 6p25.3 HGNC cytogenetic band: 6p25.3HUS1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M000655: view genomic region
(about GC identifiers)
Start:
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655,939 bp from pter |
End:
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656,964 bp from pter |
Size:
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1,026 bases |
Orientation:
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minus strand |
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Proteins
for HUS1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HUS1B_HUMAN, Q8NHY5 (See
protein sequence)Recommended Name: Checkpoint protein HUS1B Size: 278 amino acids; 30982 Da
Subunit: Interacts with RAD1 and RAD9B
Secondary accessions: Q5T4Z2Explore the universe of human proteins at neXtProt for HUS1B: NX_Q8NHY5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NHY5
HUS1B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_683762.2
ENSEMBL proteins: ENSP00000370293
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005730 | nucleolus |
IEA | -- | | GO:0030896 | checkpoint clamp complex |
IEA | -- |
HUS1B for ontologies About GeneDecksing
HUS1B Antibody Products:
Assay Products for HUS1B: |
Protein
Domains /
Families
for HUS1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HUS1B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NHY5ProtoNet protein and cluster: Q8NHY5 UniProtKB/Swiss-Prot: HUS1B_HUMAN, Q8NHY5Similarity: Belongs to the HUS1 family |
Function
for HUS1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HUS1B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HUS1B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HUS1B (NM_148959) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HUS1B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HUS1B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HUS1B |
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Pathways & Interactions
for HUS1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | p53 signaling pathway | |
1  BioSystems Pathway for HUS1B
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HUS1B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/7 Interacting proteins for HUS1B (Q8NHY53 ENSP000003702934) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000077 | DNA damage checkpoint |
IEA | -- | | GO:0006281 | DNA repair |
IEA | -- |
HUS1B for ontologies About GeneDecksing
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Drugs & Compounds
for HUS1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HUS1B
Search CenterWatch for drugs/clinical trials and news about HUS1B
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Transcripts
for HUS1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HUS1B gene: NM_148959.3 Unigene Cluster for HUS1B: HUS1 checkpoint homolog b (S. pombe) Hs.669039 [show with all ESTs]Unigene Representative Sequence: NM_1489591 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000380907(uc003mtg.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HUS1B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HUS1B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HUS1B (NM_148959) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HUS1B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HUS1B |
Additional cDNA sequence: AF508547.1 BC101697.1 BC101699.1 1 DOTS entry: DT.75178426 3 AceView cDNA sequences: NM_148959 AF508547 AI446694
GeneLoc Exon Structure
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Expression
for HUS1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HUS1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGCAAGTGC
About this image
See HUS1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HUS1B
SOURCE GeneReport for Unigene cluster: Hs.669039
UniProtKB/Swiss-Prot: HUS1B_HUMAN, Q8NHY5Tissue specificity: Expressed strongly in testis, less in spleen, thymus, prostate, colon and leukocytes
SABiosciences Custom PCR Arrays for HUS1B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HUS1B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HUS1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HUS1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HUS1B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HUS1B |
Orthologs
for HUS1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for HUS1B gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for HUS1B (if available)
TreeFam Gene Tree for HUS1B (if available) |
Paralogs
for HUS1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HUS1B gene
- HUS12
1 SIMAP similar gene for HUS1B using alignment to 1 protein entry: HUS1B_HUMAN:HUS1
HUS1B for paralogs About GeneDecksing
|
Genomic Variants
for HUS1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for HUS1B
2 CNVs: 3593 36543
Human Gene Mutation Database (HGMD): HUS1B
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for HUS1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HUS1B for disorders About GeneDecksing
OMIM gene information: 609713
OMIM disorders: --
3  diseases for HUS1B: About MalaCardsesophagitis adenocarcinoma prostatitis
Human Genome Epidemiology (HuGE) Navigator: HUS1B (1 document)
Export disorders for HUS1B gene to outside databases
|
Publications
for HUS1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HUS1B gene integrated from 9 sources:
(articles sorted by number of sources associating them with HUS1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of a paralog of human cell cycle checkpoint gene HUS1. (PubMed id 11944979)1, 2, 3 Hang H.... Lieberman H.B. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue. (PubMed id 14500360)1, 2 Hopkins K.M....Lieberman H.B. (2003)
- Linkage and association of successful aging to the 6q2 5 region in large Amish kindreds. (PubMed id 22773346)1 Edwards D.R....Scott W.K. (2012)
- A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1 Liu C.Y....Christiani D.C. (2010)
- Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene. (PubMed id 14611806)1 Dufault V.M.... Karnitz L.M. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for HUS1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing HUS1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing HUS1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HUS1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for HUS1B gene:
Search GeneIP for patents involving HUS1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HUS1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HUS1B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HUS1B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HUS1B | | | OriGene Protein Over-expression Lysate for HUS1B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HUS1B | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HUS1B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HUS1B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HUS1B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HUS1B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HUS1B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HUS1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HUS1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HUS1B |
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| | | | Search Tocris compounds for HUS1B |
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 | | | HUS1B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HUS1B |
|  |  |  | | | | Search ThermoFisher Antibodies for HUS1B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HUS1B |
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