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Aliases for HUS1B Gene

Aliases for HUS1B Gene

  • HUS1 Checkpoint Homolog B (S. Pombe) 2 3
  • HHUS1B 3 4
  • HUS1 (S. Pombe) Checkpoint Homolog B 2
  • Checkpoint Protein HUS1B 3

External Ids for HUS1B Gene

Summaries for HUS1B Gene

Entrez Gene Summary for HUS1B Gene

  • The protein encoded by this gene is most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. This protein can interact with the check point protein RAD1 but not with RAD9. Overexpression of this protein has been shown to induce cell death, which suggests a related but distinct role of this protein, as compared to the HUS1. [provided by RefSeq, Jul 2008]

GeneCards Summary for HUS1B Gene

HUS1B (HUS1 Checkpoint Homolog B (S. Pombe)) is a Protein Coding gene. Among its related pathways are p53 signaling pathway. An important paralog of this gene is HUS1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HUS1B Gene

Genomics for HUS1B Gene

Genomic Location for HUS1B Gene

Start:
655,939 bp from pter
End:
656,964 bp from pter
Size:
1,026 bases
Orientation:
Minus strand

Genomic View for HUS1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HUS1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HUS1B Gene

Regulatory Elements for HUS1B Gene

Proteins for HUS1B Gene

  • Protein details for HUS1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHY5-HUS1B_HUMAN
    Recommended name:
    Checkpoint protein HUS1B
    Protein Accession:
    Q8NHY5
    Secondary Accessions:
    • Q5T4Z2

    Protein attributes for HUS1B Gene

    Size:
    278 amino acids
    Molecular mass:
    30982 Da
    Quaternary structure:
    • Interacts with RAD1 and RAD9B.

neXtProt entry for HUS1B Gene

Proteomics data for HUS1B Gene at MOPED

Post-translational modifications for HUS1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HUS1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HUS1B Gene

Domains for HUS1B Gene

Protein Domains for HUS1B Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

HUS1B_HUMAN
Family:
  • Belongs to the HUS1 family.:
    • Q8NHY5
genes like me logo Genes that share domains with HUS1B: view

No data available for Gene Families for HUS1B Gene

Function for HUS1B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HUS1B Gene

Localization for HUS1B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HUS1B Gene COMPARTMENTS Subcellular localization image for HUS1B gene
Compartment Confidence
nucleus 2
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HUS1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
GO:0030896 checkpoint clamp complex IBA --
GO:0035861 site of double-strand break IBA --
genes like me logo Genes that share ontologies with HUS1B: view

Pathways for HUS1B Gene

SuperPathways for HUS1B Gene

Superpath Contained pathways
1 p53 signaling pathway
genes like me logo Genes that share pathways with HUS1B: view

Pathways by source for HUS1B Gene

1 BioSystems pathway for HUS1B Gene

Gene Ontology (GO) - Biological Process for HUS1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000077 DNA damage checkpoint --
GO:0000724 double-strand break repair via homologous recombination IBA --
GO:0006281 DNA repair --
GO:0006289 nucleotide-excision repair IBA --
GO:0031573 intra-S DNA damage checkpoint IBA --
genes like me logo Genes that share ontologies with HUS1B: view

Transcripts for HUS1B Gene

mRNA/cDNA for HUS1B Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HUS1B Gene

HUS1 checkpoint homolog b (S. pombe):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HUS1B Gene

No ASD Table

Relevant External Links for HUS1B Gene

GeneLoc Exon Structure for
HUS1B
ECgene alternative splicing isoforms for
HUS1B

Expression for HUS1B Gene

mRNA expression in normal human tissues for HUS1B Gene

mRNA differential expression in normal tissues according to GTEx for HUS1B Gene

This gene is overexpressed in Testis (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HUS1B Gene

SOURCE GeneReport for Unigene cluster for HUS1B Gene Hs.669039

mRNA Expression by UniProt/SwissProt for HUS1B Gene

Q8NHY5-HUS1B_HUMAN
Tissue specificity: Expressed strongly in testis, less in spleen, thymus, prostate, colon and leukocytes.
genes like me logo Genes that share expressions with HUS1B: view

Orthologs for HUS1B Gene

This gene was present in the common ancestor of animals.

Orthologs for HUS1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HUS1B 36
  • 97.48 (n)
  • 94.6 (a)
mouse
(Mus musculus)
Mammalia Hus1b 36
  • 74.55 (n)
  • 65.09 (a)
Hus1b 16
Hus1b 37
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 57 (a)
ManyToMany
-- 37
  • 41 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 37
  • 49 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 44 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii HUS1 37
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Hus1-like 37
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hus-1 37
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7579 37
  • 36 (a)
OneToMany
Species with no ortholog for HUS1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HUS1B Gene

ENSEMBL:
Gene Tree for HUS1B (if available)
TreeFam:
Gene Tree for HUS1B (if available)

Paralogs for HUS1B Gene

Paralogs for HUS1B Gene

Selected SIMAP similar genes for HUS1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HUS1B: view

Variants for HUS1B Gene

Sequence variations from dbSNP and Humsavar for HUS1B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
VAR_025497 -
VAR_031206 -
VAR_031207 -

Structural Variations from Database of Genomic Variants (DGV) for HUS1B Gene

Variant ID Type Subtype PubMed ID
esv581 CNV CNV 17122850
essv22330 CNV CNV 17122850
nsv462609 CNV Gain 19166990
nsv883361 CNV Gain 21882294
nsv5169 CNV Loss 18451855

Relevant External Links for HUS1B Gene

HapMap Linkage Disequilibrium report
HUS1B
Human Gene Mutation Database (HGMD)
HUS1B

Disorders for HUS1B Gene

Relevant External Links for HUS1B

Genetic Association Database (GAD)
HUS1B
Human Genome Epidemiology (HuGE) Navigator
HUS1B
genes like me logo Genes that share disorders with HUS1B: view

No data available for UniProtKB/Swiss-Prot for HUS1B Gene

Publications for HUS1B Gene

  1. Identification and characterization of a paralog of human cell cycle checkpoint gene HUS1. (PMID: 11944979) Hang H. … Lieberman H.B. (Genomics 2002) 2 3 4
  2. Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue. (PMID: 14500360) Hopkins K.M. … Lieberman H.B. (Cancer Res. 2003) 3 4
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu C.Y. … Christiani D.C. (Carcinogenesis 2010) 3 49

Products for HUS1B Gene

Sources for HUS1B Gene

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