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Aliases for HUS1B Gene

Aliases for HUS1B Gene

  • HUS1 Checkpoint Clamp Component B 2 3 5
  • HHUS1B 3 4
  • HUS1 (S. Pombe) Checkpoint Homolog B 2
  • HUS1 Checkpoint Homolog B (S. Pombe) 2
  • HUS1 Checkpoint Homolog B 3
  • Checkpoint Protein HUS1B 3

External Ids for HUS1B Gene

Previous GeneCards Identifiers for HUS1B Gene

  • GC06M000646
  • GC06M000600

Summaries for HUS1B Gene

Entrez Gene Summary for HUS1B Gene

  • The protein encoded by this gene is most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. This protein can interact with the check point protein RAD1 but not with RAD9. Overexpression of this protein has been shown to induce cell death, which suggests a related but distinct role of this protein, as compared to the HUS1. [provided by RefSeq, Jul 2008]

GeneCards Summary for HUS1B Gene

HUS1B (HUS1 Checkpoint Clamp Component B) is a Protein Coding gene. Among its related pathways are DNA damage response. An important paralog of this gene is HUS1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HUS1B Gene

Genomics for HUS1B Gene

Regulatory Elements for HUS1B Gene

Enhancers for HUS1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F000679 0.8 Ensembl ENCODE 13.6 -25.9 -25860 5.8 HDGF PKNOX1 FEZF1 ZNF2 ETS1 ZNF302 KLF7 ZNF263 SP3 JUNB EXOC2 HUS1B ENSG00000272463 LOC100421511
GH06F000304 0.5 FANTOM5 10.2 +352.9 352903 0.1 CTCF EED HUS1B GC06P000310 LOC102723922
GH06F000466 0.3 FANTOM5 6.1 +190.2 190155 0.1 HUS1B GC06P000461 GC06P000481
GH06F000472 0.4 FANTOM5 2.9 +184.3 184270 0.0 HUS1B EXOC2 GC06P000481 GC06P000461
GH06F001003 0.3 FANTOM5 2.5 -346.7 -346744 0.3 L3MBTL2 ELF1 ZBTB40 ZFX GABPA HUS1B PIR33232 GC06M001018
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HUS1B on UCSC Golden Path with GeneCards custom track

Genomic Location for HUS1B Gene

655,939 bp from pter
656,964 bp from pter
1,026 bases
Minus strand

Genomic View for HUS1B Gene

Genes around HUS1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HUS1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HUS1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HUS1B Gene

Proteins for HUS1B Gene

  • Protein details for HUS1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Checkpoint protein HUS1B
    Protein Accession:
    Secondary Accessions:
    • Q5T4Z2

    Protein attributes for HUS1B Gene

    278 amino acids
    Molecular mass:
    30982 Da
    Quaternary structure:
    • Interacts with RAD1 and RAD9B.

neXtProt entry for HUS1B Gene

Post-translational modifications for HUS1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HUS1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HUS1B Gene

Domains & Families for HUS1B Gene

Protein Domains for HUS1B Gene


Suggested Antigen Peptide Sequences for HUS1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the HUS1 family.
  • Belongs to the HUS1 family.
genes like me logo Genes that share domains with HUS1B: view

No data available for Gene Families for HUS1B Gene

Function for HUS1B Gene

genes like me logo Genes that share phenotypes with HUS1B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HUS1B Gene

Localization for HUS1B Gene

Subcellular locations from

Jensen Localization Image for HUS1B Gene COMPARTMENTS Subcellular localization image for HUS1B gene
Compartment Confidence
nucleus 4
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HUS1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
GO:0030896 checkpoint clamp complex IBA --
GO:0035861 site of double-strand break IBA --
genes like me logo Genes that share ontologies with HUS1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HUS1B Gene

Pathways & Interactions for HUS1B Gene

genes like me logo Genes that share pathways with HUS1B: view

Pathways by source for HUS1B Gene

2 BioSystems pathways for HUS1B Gene

Gene Ontology (GO) - Biological Process for HUS1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IBA --
GO:0006281 DNA repair IEA --
GO:0006289 nucleotide-excision repair IBA --
GO:0031573 intra-S DNA damage checkpoint IBA --
GO:0033314 mitotic DNA replication checkpoint IBA --
genes like me logo Genes that share ontologies with HUS1B: view

No data available for SIGNOR curated interactions for HUS1B Gene

Transcripts for HUS1B Gene

mRNA/cDNA for HUS1B Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HUS1B Gene

HUS1 checkpoint homolog b (S. pombe):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HUS1B Gene

No ASD Table

Relevant External Links for HUS1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HUS1B Gene

mRNA expression in normal human tissues for HUS1B Gene

mRNA differential expression in normal tissues according to GTEx for HUS1B Gene

This gene is overexpressed in Testis (x6.0).

Protein differential expression in normal tissues from HIPED for HUS1B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HUS1B Gene

Protein tissue co-expression partners for HUS1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HUS1B Gene:


SOURCE GeneReport for Unigene cluster for HUS1B Gene:


mRNA Expression by UniProt/SwissProt for HUS1B Gene:

Tissue specificity: Expressed strongly in testis, less in spleen, thymus, prostate, colon and leukocytes.
genes like me logo Genes that share expression patterns with HUS1B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for HUS1B Gene

Orthologs for HUS1B Gene

This gene was present in the common ancestor of animals.

Orthologs for HUS1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HUS1B 34
  • 97.48 (n)
(Mus musculus)
Mammalia Hus1b 34 16 35
  • 74.55 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 57 (a)
-- 35
  • 41 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 51 (a)
(Gallus gallus)
Aves -- 35
  • 49 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 44 (a)
(Danio rerio)
Actinopterygii HUS1 35
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hus1-like 35
  • 26 (a)
(Caenorhabditis elegans)
Secernentea hus-1 35
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7579 35
  • 36 (a)
Species where no ortholog for HUS1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HUS1B Gene

Gene Tree for HUS1B (if available)
Gene Tree for HUS1B (if available)

Paralogs for HUS1B Gene

Paralogs for HUS1B Gene

(1) SIMAP similar genes for HUS1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HUS1B: view

Variants for HUS1B Gene

Sequence variations from dbSNP and Humsavar for HUS1B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10657323 -- 658,679(+) TTTTT(-/TT)AGACG intron-variant, upstream-variant-2KB
rs11243051 -- 657,942(+) ACACT(A/G)TTTTT intron-variant, upstream-variant-2KB
rs11243052 -- 657,954(+) GTATT(C/G)TTTGC intron-variant, upstream-variant-2KB
rs11243053 -- 657,996(+) ACCTA(C/T)TGACC intron-variant, upstream-variant-2KB
rs11319548 -- 657,765(+) CAGGC(-/A)AAAAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HUS1B Gene

Variant ID Type Subtype PubMed ID
esv2759401 CNV gain+loss 17122850
esv3576089 CNV gain 25503493
esv3607835 CNV loss 21293372
esv3607858 CNV loss 21293372
esv3607859 CNV gain 21293372
nsv1023279 CNV gain 25217958
nsv462609 CNV gain 19166990
nsv5169 CNV deletion 18451855
nsv600781 CNV gain 21841781
nsv600782 CNV gain 21841781

Variation tolerance for HUS1B Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.33; 53.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HUS1B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HUS1B Gene

Disorders for HUS1B Gene

Relevant External Links for HUS1B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HUS1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HUS1B Gene

Publications for HUS1B Gene

  1. Identification and characterization of a paralog of human cell cycle checkpoint gene HUS1. (PMID: 11944979) Hang H. … Lieberman H.B. (Genomics 2002) 2 3 4 64
  2. Clamping down on mammalian meiosis. (PMID: 24013428) Lyndaker A.M. … Lieberman H.B. (Cell Cycle 2013) 2 3 64
  3. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu C.Y. … Christiani D.C. (Carcinogenesis 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue. (PMID: 14500360) Hopkins K.M. … Lieberman H.B. (Cancer Res. 2003) 3 4 64

Products for HUS1B Gene

Sources for HUS1B Gene

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