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HUS1 Gene

protein-coding   GIFtS: 65
GCID: GC07M047735

HUS1 Checkpoint Homolog (S. Pombe)

(Previous name: HUS1 (S. pombe) checkpoint homolog)
  Search for HUS1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
HUS1 Checkpoint Homolog (S. Pombe)1 2
Hus1+-Like Protein1 2
hHUS12 3
HUS1 (S. Pombe) Checkpoint Homolog1
Checkpoint Protein HUS12

External Ids:    HGNC: 53091   Entrez Gene: 33642   Ensembl: ENSG000001362737   OMIM: 6037605   UniProtKB: O609213   

Export aliases for HUS1 gene to outside databases

Previous GC identifers: GC07M047650 GC07M047744 GC07M047777 GC07M047969


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HUS1 Gene:
The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint
complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric
complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with
another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor
C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been
shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint
signaling event. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Feb 2011)

GeneCards Summary for HUS1 Gene:
HUS1 (HUS1 checkpoint homolog (S. pombe)) is a protein-coding gene. An important paralog of this gene is HUS1B.

UniProtKB/Swiss-Prot: HUS1_HUMAN, O60921
Function: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The
9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader
complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision
repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for
the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1
cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase
I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of
RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase

Gene Wiki entry for HUS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HUS1 gene promoter:
         Max1   Spz1   C/EBPbeta   AML1a   POU6F1 (c2)   STAT5A   Evi-1   FAC1   RSRFC4   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HUS1 promoter sequence
   Search Chromatin IP Primers for HUS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HUS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13-p12   Ensembl cytogenetic band:  7p12.3   HGNC cytogenetic band: 7p13-p12

HUS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HUS1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M047735:  view genomic region     (about GC identifiers)

Start:
47,735,328 bp from pter      End:
48,019,222 bp from pter
Size:
283,895 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 48,042,830-48,059,174     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HUS1_HUMAN, O60921 (See protein sequence)
Recommended Name: Checkpoint protein HUS1  
Size: 280 amino acids; 31691 Da
Subunit: Component of the toroidal 9-1-1 (RAD9-RAD1-HUS1) complex, composed of RAD9A, RAD1 and HUS1. The 9-1-1
complex associates with LIG1, POLB, FEN1, RAD17, HDAC1, RPA1 and RPA2. The 9-1-1 complex associates with the
RAD17-RFC complex. HUS1 interacts with POLB, HDAC1, FEN1, PCNA, RAD1, RAD9A and RAD9B. HUS1 does not interact
with RAD17. Interacts with DNAJC7
3 PDB 3D structures from and Proteopedia for HUS1:
3A1J (3D)        3G65 (3D)        3GGR (3D)    

Explore the universe of human proteins at neXtProt for HUS1: NX_O60921

Explore proteomics data for HUS1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys136
  • Modification sites at PhosphoSitePlus

  • See HUS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004498.1  
    ENSEMBL proteins: 
     ENSP00000403844   ENSP00000258774   ENSP00000400727   ENSP00000416588   ENSP00000404348  
     ENSP00000404855   ENSP00000405175   ENSP00000398806  
    Reactome Protein details: O60921

    HUS1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for HUS1

     
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    Search eBioscience for ELISAs for HUS1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR007150 Hus1/Mec3
     IPR016580 Cell_cycle_HUS1

    Graphical View of Domain Structure for InterPro Entry O60921

    ProtoNet protein and cluster: O60921

    UniProtKB/Swiss-Prot: HUS1_HUMAN, O60921
    Similarity: Belongs to the HUS1 family


    Find genes that share domains with HUS1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HUS1_HUMAN, O60921
    Function: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The
    9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader
    complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision
    repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for
    the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1
    cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase
    I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of
    RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase

         Genatlas biochemistry entry for HUS1:
    cell cycle G2 checkpoint control gene,homologous to S pombe Hos1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10359610
         
    Find genes that share ontologies with HUS1           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Hus1):
     cardiovascular system  cellular  embryogenesis  growth/size/body  hematopoietic system 
     limbs/digits/tail  mortality/aging  nervous system  tumorigenesis 

    Find genes that share phenotypes with HUS1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for HUS1: Hus1tm1Led Hus1tm1.1Rsw

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HUS1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HUS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HUS1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HUS1

    miRNA
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    miRTarBase miRNAs that target HUS1:
    hsa-mir-30c-5p (MIRT047873)

    Block miRNA regulation of human, mouse, rat HUS1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HUS1:
    hsa-miR-200c* hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmidHUS1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HUS1
    Predesigned siRNA for gene silencing in human, mouse, rat HUS1

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    GenScript: all cDNA clones in your preferred vector: HUS1 (NM_004507)
    Sino Biological Human cDNA Clone for HUS1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HUS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HUS1

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    Browse ESI BIO Cell Lines and PureStem Progenitors for HUS1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HUS1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HUS1_HUMAN, O60921: Nucleus. Cytoplasm. Note=In discrete nuclear foci upon DNA damage. According to
    PubMed:14500360, localized also in the cytoplasm. DNA damage induces its nuclear translocation. Shuttles between
    the nucleus and the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    golgi apparatus4
    cytosol2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10846170
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005794Golgi apparatus ----

    Find genes that share ontologies with HUS1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HUS1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1G2/M Checkpoints
    G2/M Checkpoints0.84
    Activation of ATR in response to replication stress0.84
    2Chks in Checkpoint Regulation
    Chks in Checkpoint Regulation0.59
    DNA Repair Mechanisms0.32
    3Cell Cycle, Mitotic
    Cell Cycle0.90
    4CDK-mediated phosphorylation and removal of Cdc6
    Cell Cycle Checkpoints0.58
    5Cell cycle Role of 14 3 3 proteins in cell cycle regulation
    Cell cycle Role of 14 3 3 proteins in cell cycle regulation0.45


    Find genes that share SuperPaths with HUS1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HUS1
        DNA Repair Mechanisms
    Chks in Checkpoint Regulation
    DNA Damage Induced 14-3-3Sigma Signaling

    1 GeneGo (Thomson Reuters) Pathway for HUS1
        Cell cycle Role of 14-3-3 proteins in cell cycle regulation

    1 BioSystems Pathway for HUS1
        Regulation of Telomerase


    1 Reactome Pathway for HUS1
        Activation of ATR in response to replication stress


        Pathway & Disease-focused RT2 Profiler PCR Arrays including HUS1: 
              Cell Cycle in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HUS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HUS1 (O609211, 2, 3 ENSP000002587744) via UniProtKB, MINT, STRING, and/or I2D (see all 89)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAD9AQ996381, 3, ENSP000003113604EBI-1056174,EBI-2606224 I2D: score=4 STRING: ENSP00000311360
    RAD1O606711, 3, ENSP000003408794EBI-1056174,EBI-721835 I2D: score=3 STRING: ENSP00000340879
    YWHAZP631042, 3, ENSP000003095034MINT-3318251 I2D: score=1 STRING: ENSP00000309503
    PCNAP120043, ENSP000003684384I2D: score=2 STRING: ENSP00000368438
    ALDOBP050623, ENSP000003639884I2D: score=1 STRING: ENSP00000363988
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077DNA damage checkpoint IMP--
    GO:0000724double-strand break repair via homologous recombination IEA--
    GO:0001932regulation of protein phosphorylation IEA--
    GO:0006260DNA replication TAS--
    GO:0006281DNA repair TAS9872989

    Find genes that share ontologies with HUS1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HUS1

    1 Novoseek inferred chemical compound relationship for HUS1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydroxyurea 47.7 3 11077446 (1), 17327271 (1)



    Find genes that share compounds with HUS1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HUS1 gene: 
    NM_004507.3  

    Unigene Cluster for HUS1:

    HUS1 checkpoint homolog (S. pombe)
    Hs.152983  [show with all ESTs]
    Unigene Representative Sequence: NM_004507
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436444 ENST00000258774(uc003tod.2) ENST00000458191 ENST00000432325
    ENST00000442024 ENST00000432627 ENST00000433977 ENST00000446009 ENST00000468868

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate HUS1:
    hsa-miR-200c* hsa-miR-550a*
    SwitchGear 3'UTR luciferase reporter plasmidHUS1 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HUS1
      QuantiTect SYBR Green Assays in human, mouse, rat HUS1
      QuantiFast Probe-based Assays in human, mouse, rat HUS1

    Additional mRNA sequence: 

    AJ227901.1 AK097182.1 AK290459.1 AK294117.1 BC007013.1 BT019481.1 BT019482.1 CR536552.1 
    NR_037917.1 Y16893.1 

    8 DOTS entries:

    DT.310408  DT.70103554  DT.92424430  DT.102823648  DT.92424429  DT.95259816  DT.91652334  DT.95362322 

    Selected AceView cDNA sequences (see all 87):

    AW132130 CR536552 BU193379 CR619988 BX500811 BQ646867 BC007013 AL554895 
    NM_004507 AI538328 CA418558 AI167268 BF222727 R95460 AA854956 AA828114 
    AL577506 AI149713 Y16893 BU680921 BU600981 AA897773 BU932644 AA353895 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for HUS1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11
    SP1:              -                 -           -           -                 -                     
    SP2:                                                                          -                     
    SP3:                                -                                                               
    SP4:              -                                                                                 
    SP5:                                                                                                


    ECgene alternative splicing isoforms for HUS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HUS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HUS1 Expression
    About this image


    HUS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    HUS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HUS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.152983

    UniProtKB/Swiss-Prot: HUS1_HUMAN, O60921
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HUS1: 
              Cell Cycle in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HUS1
    OriGene qSTAR qPCR primer pairs in human, mouse for HUS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HUS1
    QuantiTect SYBR Green Assays in human, mouse, rat HUS1
    QuantiFast Probe-based Assays in human, mouse, rat HUS1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HUS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HUS1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hus11 , 5 Hus1 homolog (S. pombe)1, 5 83.57(n)1
    86.07(a)1
      11 (5.74 cM)5
    155741  NM_008316.41  NP_032342.11 
     89931375 
    chicken
    (Gallus gallus)
    Aves HUS11 HUS1 checkpoint homolog (S. pombe) 74.64(n)
    76.07(a)
      428471  XM_426029.4  XP_426029.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    74(a)
    1 → many
    6(53962631-53984555)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985712 Hus1 protein 76.55(n)    AY169966.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1628951 zgc:162895 65.35(n)
    65.95(a)
      100037341  NM_001089496.1  NP_001082965.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hus1-like1 Hus1-like 44.16(n)
    31.37(a)
      40598  NM_001275338.1  NP_001262267.1 
    worm
    (Caenorhabditis elegans)
    Secernentea hus-11 hus-1 43.16(n)
    32.46(a)
      171939  NM_058802.6  NP_491203.1 


    ENSEMBL Gene Tree for HUS1 (if available)
    TreeFam Gene Tree for HUS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HUS1 gene
    HUS1B2  
    1 SIMAP similar gene for HUS1 using alignment to 7 protein entries:     HUS1_HUMAN (see all proteins):
    HUS1B

    Find genes that share paralogs with HUS1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HUS1 (see all 446)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1818277331,2
    --48002393(+) AATTGC/TCTGGG 2 -- int10--------
    rs1852270521,2
    --48002454(+) TGTGCC/GTACCA 2 -- int10--------
    rs1896988321,2
    --48002661(+) CAAATC/TATATT 2 -- int10--------
    rs1392118151,2
    --48002704(+) TGACCC/TGGCAA 2 -- int10--------
    rs1806823661,2
    --48002729(+) AGATCA/TTTCAA 2 -- int10--------
    rs31766211,2
    C,F--48002895(-) CTTAGT/ATGAGA 2 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.01NS 170
    rs1865807041,2
    --48002970(+) ATATGC/TATTTG 2 -- ut31 nc-transcript-variant0--------
    rs31766201,2
    C--48003065(-) TGAAACA/-ATATC 2 -- ut31 nc-transcript-variant1Minor allele frequency- -:0.01NS 180
    rs31766191,2
    C,F,H--48003197(-) GATGGA/GATATT 2 -- ut31 nc-transcript-variant6Minor allele frequency- G:0.07NS EA 1024
    rs31766181,2
    F--48003214(-) TAATAA/GTGTTG 2 -- ut31 nc-transcript-variant1Minor allele frequency- G:0.01NS 174

    HapMap Linkage Disequilibrium report for HUS1 (47735328 - 47985328 bp, first 250kb of HUS1)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for HUS1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734364CNV Deletion23290073
    esv2387830CNV Deletion18987734
    esv2734363CNV Deletion23290073
    esv2734365CNV Deletion23290073
    nsv830991CNV Loss17160897
    nsv470221CNV Gain18288195
    nsv464442CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HUS1
    DNA2.0 Custom Variant and Variant Library Synthesis for HUS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603760    OMIM disorders: --


    Find genes that share disorders with HUS1           About GenesLikeMe

    2 Novoseek inferred disease relationships for HUS1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 18156970 (2)
    cancer 0 1 18156970 (1)

    Genetic Association Database (GAD): HUS1
    Human Genome Epidemiology (HuGE) Navigator: HUS1 (9 documents)

    Export disorders for HUS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HUS1 gene, integrated from 10 sources (see all 83):
    (articles sorted by number of sources associating them with HUS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster. (PubMed id 9878245)1, 2, 3, 9 Dean F.B.... O'Donnell M. (Genomics 1998)
    2. Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage. (PubMed id 9524127)1, 2, 3 Kostrub C.F.... Enoch T. (EMBO J. 1998)
    3. The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9. (PubMed id 10884395)1, 2, 9 Rauen M.... Karnitz L.M. (J. Biol. Chem. 2000)
    4. HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins. (PubMed id 10846170)1, 2, 9 Cai R.L.... Cohen D. (J. Biol. Chem. 2000)
    5. PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition. (PubMed id 11077446)1, 2, 9 Komatsu K.... Wang H.-G. (Oncogene 2000)
    6. The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1. (PubMed id 10359610)1, 2, 9 St Onge R.P.... Davey S. (Mol. Biol. Cell 1999)
    7. The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9. (PubMed id 11573955)1, 2, 9 Xiang S.L....Yamamoto K.C. (Biochem. Biophys. Res. Commun. 2001)
    8. Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells. (PubMed id 15897895)1, 2, 9 Wu X.... Zou Y. (Oncogene 2005)
    9. The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair. (PubMed id 15314187)1, 2, 9 Toueille M....Huebscher U. (Nucleic Acids Res. 2004)
    10. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3364 HGNC: 5309 AceView: HUS1 Ensembl:ENSG00000136273 euGenes: HUgn3364
    ECgene: HUS1 H-InvDB: HUS1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HUS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HUS1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/hus1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HUS1 gene:
    Search GeneIP for patents involving HUS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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