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Aliases for HUNK Gene

Aliases for HUNK Gene

  • Hormonally Up-Regulated Neu-Associated Kinase 2 3
  • Hormonally Upregulated Neu-Associated Kinase 2 3
  • Serine/Threonine-Protein Kinase MAK-V 3 4
  • EC 4 63
  • B19 3 4
  • Hormonally Up-Regulated Neu Tumor-Associated Kinase 3
  • Hormonally Upregulated Neu Tumor-Associated Kinase 3
  • Serine/Threonine Protein Kinase MAK-V 3
  • EC 2.7.11 63
  • MAKV 4

External Ids for HUNK Gene

Previous GeneCards Identifiers for HUNK Gene

  • GC21P029823
  • GC21P032166
  • GC21P032167
  • GC21P033245
  • GC21P018704

Summaries for HUNK Gene

GeneCards Summary for HUNK Gene

HUNK (Hormonally Up-Regulated Neu-Associated Kinase) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is NUAK1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HUNK Gene

Genomics for HUNK Gene

Regulatory Elements for HUNK Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HUNK Gene

31,873,315 bp from pter
32,044,633 bp from pter
171,319 bases
Plus strand

Genomic View for HUNK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HUNK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HUNK Gene

Proteins for HUNK Gene

  • Protein details for HUNK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hormonally up-regulated neu tumor-associated kinase
    Protein Accession:
    Secondary Accessions:

    Protein attributes for HUNK Gene

    714 amino acids
    Molecular mass:
    79686 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HUNK Gene

Proteomics data for HUNK Gene at MOPED

Selected DME Specific Peptides for HUNK Gene

Post-translational modifications for HUNK Gene

  • Ubiquitination at Lys483
  • Modification sites at PhosphoSitePlus

Other Protein References for HUNK Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for HUNK Gene

Gene Families for HUNK Gene

Suggested Antigen Peptide Sequences for HUNK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P57058
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with HUNK: view

Function for HUNK Gene

Molecular function for HUNK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB) for HUNK Gene

Gene Ontology (GO) - Molecular Function for HUNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with HUNK: view

Phenotypes for HUNK Gene

genes like me logo Genes that share phenotypes with HUNK: view

Animal Models for HUNK Gene

MGI Knock Outs for HUNK:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HUNK

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for HUNK Gene

Localization for HUNK Gene

Subcellular locations from

Jensen Localization Image for HUNK Gene COMPARTMENTS Subcellular localization image for HUNK gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HUNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with HUNK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HUNK Gene

Pathways for HUNK Gene

SuperPathways for HUNK Gene

No Data Available

Gene Ontology (GO) - Biological Process for HUNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IBA --
GO:0007165 signal transduction TAS 10662544
GO:0007275 multicellular organismal development TAS 10662544
GO:0009103 lipopolysaccharide biosynthetic process --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with HUNK: view

No data available for Pathways by source for HUNK Gene

Compounds for HUNK Gene

(2) HMDB Compounds for HUNK Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
genes like me logo Genes that share compounds with HUNK: view

Transcripts for HUNK Gene

mRNA/cDNA for HUNK Gene

Unigene Clusters for HUNK Gene

Hormonally up-regulated Neu-associated kinase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HUNK

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HUNK Gene

No ASD Table

Relevant External Links for HUNK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HUNK Gene

mRNA expression in normal human tissues for HUNK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HUNK Gene

This gene is overexpressed in Pancreas (4.0).

Protein differential expression in normal tissues for HUNK Gene

This gene is overexpressed in Liver (57.3) and Ovary (11.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HUNK Gene

SOURCE GeneReport for Unigene cluster for HUNK Gene Hs.109437

genes like me logo Genes that share expressions with HUNK: view

Expression partners for HUNK Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HUNK Gene

Orthologs for HUNK Gene

This gene was present in the common ancestor of animals.

Orthologs for HUNK Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HUNK 35
  • 88.92 (n)
  • 92.35 (a)
  • 91 (a)
(Canis familiaris)
Mammalia HUNK 35
  • 88.47 (n)
  • 90.63 (a)
  • 89 (a)
(Mus musculus)
Mammalia Hunk 35
  • 87.35 (n)
  • 92.44 (a)
Hunk 16
Hunk 36
  • 92 (a)
(Pan troglodytes)
Mammalia HUNK 35
  • 99.16 (n)
  • 99.72 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Hunk 35
  • 87.72 (n)
  • 92.16 (a)
(Monodelphis domestica)
Mammalia HUNK 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia HUNK 36
  • 57 (a)
(Gallus gallus)
Aves HUNK 35
  • 69.96 (n)
  • 69.06 (a)
  • 72 (a)
(Anolis carolinensis)
Reptilia HUNK 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hunk 35
  • 67.9 (n)
  • 66.91 (a)
Str.7077 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24322 35
(Danio rerio)
Actinopterygii hunk 36
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta trbl 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea DC2.7a 37
  • 39 (a)
nipi-3 36
  • 13 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.399 35
Species with no ortholog for HUNK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HUNK Gene

Gene Tree for HUNK (if available)
Gene Tree for HUNK (if available)

Paralogs for HUNK Gene

Paralogs for HUNK Gene Pseudogenes for HUNK Gene

genes like me logo Genes that share paralogs with HUNK: view

Variants for HUNK Gene

Sequence variations from dbSNP and Humsavar for HUNK Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs3576 -- 32,001,799(-) AGTCA(C/T)GGTCG utr-variant-3-prime
rs3578 -- 32,001,789(-) GAACA(A/G)ACAAC utr-variant-3-prime
rs737103 -- 31,983,447(+) CGCTG(A/G)TTTAA intron-variant
rs743303 -- 31,949,674(-) ATTCC(C/T)TTGCA intron-variant
rs762213 -- 31,977,890(+) acggg(C/G)tttcg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HUNK Gene

Variant ID Type Subtype PubMed ID
nsv834081 CNV Loss 17160897
nsv834082 CNV Gain 17160897
nsv510793 CNV Loss 20534489
dgv1372e1 CNV Complex 17122850
nsv913680 CNV Gain 21882294
esv2723338 CNV Deletion 23290073
esv2060229 CNV Deletion 18987734
esv2723340 CNV Deletion 23290073
esv998414 CNV Deletion 20482838
esv1172635 CNV Deletion 17803354
nsv3492 CNV Insertion 18451855
esv2723341 CNV Deletion 23290073
nsv518119 CNV Loss 19592680

Relevant External Links for HUNK Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HUNK Gene

Disorders for HUNK Gene

Relevant External Links for HUNK

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for HUNK Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for HUNK Gene

Publications for HUNK Gene

  1. HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1. (PMID: 20133759) Quintela-Fandino M. … Mak T.W. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 23
  2. Cloning and characterization of Hunk, a novel mammalian SNF1-related protein kinase. (PMID: 10662544) Gardner H.P. … Chodosh L.A. (Genomics 2000) 2 3
  3. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 2 3
  4. The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PMID: 17203973) Vasilescu J. … Figeys D. (J. Proteome Res. 2007) 3 4
  5. Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8. (PMID: 19890347) Birlea S.A. … Spritz R.A. (J. Invest. Dermatol. 2010) 3 48

Products for HUNK Gene

Sources for HUNK Gene

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