HUNK Gene
protein-coding GIFtS: 53
GCID: GC21P033245
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hormonally up-regulated Neu-associated kinase(Previous name: hormonally upregulated Neu-associated kinase )
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Aliases
for HUNK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Hormonally Up-Regulated Neu-Associated Kinase1 2 | | Hormonally Up-Regulated Neu Tumor-Associated Kinase2 | | Hormonally Upregulated Neu-Associated Kinase1 2 | | Hormonally Upregulated Neu Tumor-Associated Kinase2 | | Serine/Threonine-Protein Kinase MAK-V2 3 | | Serine/Threonine Protein Kinase MAK-V2 | | B192 3 | | MAKV3 | | EC 2.7.11.13 8 | | EC 2.7.118 |
Export aliases for HUNK gene to outside databasesPrevious GC identifers: GC21P029823 GC21P032166 GC21P032167 GC21P018704 |
Summaries
for HUNK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for HUNK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000021.8 NC_018932.1 NT_011512.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HUNK gene promoter:
AREB6 Spz1 AP-1 Pax-6 Sox9 MyoD FOXO1a FOXO1 GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HUNK
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HUNK |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 21q22.1 Ensembl cytogenetic band: 21q22.11 HGNC cytogenetic band: 21q22.1HUNK Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 21 GeneLoc Exon Structure GeneLoc location for GC21P033245: view genomic region
(about GC identifiers)
Start:
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33,245,628 bp from pter |
End:
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33,416,946 bp from pter |
Size:
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171,319 bases |
Orientation:
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plus strand |
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Proteins
for HUNK gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HUNK_HUMAN, P57058 (See
protein sequence)Recommended Name: Hormonally up-regulated neu tumor-associated kinase Size: 714 amino acids; 79686 DaExplore the universe of human proteins at neXtProt for HUNK: NX_P57058
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P57058
4/9 DME Specific Peptides for HUNK (P57058) (see all 9)
HUNK Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055401.1
ENSEMBL proteins: ENSP00000270112 ENSP00000411860 ENSP00000408219
Human Recombinant Protein Products:
HUNK Antibody Products:
Assay Products for HUNK: |
Protein
Domains /
Families
for HUNK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HUNK for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P57058ProtoNet protein and cluster: P57058 UniProtKB/Swiss-Prot: HUNK_HUMAN, P57058Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamilySimilarity: Contains 1 protein kinase domain |
Function
for HUNK gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HUNK_HUMAN, P57058Catalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HUNK (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HUNK
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HUNK |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004672 | protein kinase activity |
-- | -- | | GO:0004674 | protein serine/threonine kinase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- |
HUNK for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for HUNK:
Animal Models:
Mouse knock-out Hunktm1Lach for HUNK
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Hunk):
HUNK for phenotypes About GeneDecksing
|
Pathways & Interactions
for HUNK gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HUNK
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/7 Interacting proteins for HUNK (P570582, 3 ENSP000002701124) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
HUNK for ontologies About GeneDecksing
|
Drugs & Compounds
for HUNK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HUNK
2 HMDB Compounds for HUNK About this table
Search CenterWatch for drugs/clinical trials and news about HUNK
|
Transcripts
for HUNK gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HUNK gene: NM_014586.1 Unigene Cluster for HUNK: Hormonally up-regulated Neu-associated kinase Hs.109437 [show with all ESTs]Unigene Representative Sequence: AJ2717224 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000270112(uc002yph.3) ENST00000430354 ENST00000465574 ENST00000439107
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HUNK (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HUNK
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HUNK (NM_014586) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HUNK | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HUNK |
Additional cDNA sequence: AF086072.1 AJ271722.1 3 DOTS entries: DT.40272011 DT.99965214 DT.102827642 24/45 AceView cDNA sequences (see all 45): BM721431 AJ271722 NM_014586 AA026437 AI275788 CD625792 CD625800 CD625798 BX492801 BQ650402 BF529471 AI669454 BQ437302 BM677084 CD625790 CD656415 BQ644781 BF337824 BE745128 BQ890524 AI868739 CD625794 AF086072 N22405
GeneLoc Exon Structure
|
Expression
for HUNK gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HUNK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTTTGTTC
About this image
See HUNK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HUNK
SOURCE GeneReport for Unigene cluster: Hs.109437
SABiosciences Custom PCR Arrays for HUNK
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HUNK
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HUNK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HUNK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HUNK | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HUNK |
Orthologs
for HUNK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HUNK gene from 4/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
HUNK1 |
hormonally upregulated Neu-associated kinase |
68.66(n)
66.27(a) |
|
418493 XM_003640478.1 XP_003640526.1 |
lizard
(Anolis carolinensis) |
Reptilia |
HUNK6-- |
-- |
67(a)59(a) |
1 ↔ 1possible ortholog |
3(145491459-145564184) 1(196614554-196634738) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.243222 |
Xenopus laevis transcribed sequence with strong similarity more |
80.38(n) |
|
BJ072362.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
hunk1 |
hormonally up-regulated Neu-associated kinase |
57.96(n)
54.45(a) |
|
564235 XM_687579.4 XP_692671.3 |
ENSEMBL Gene Tree for HUNK (if available)
TreeFam Gene Tree for HUNK (if available) |
Paralogs
for HUNK gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HUNK gene
- TSSK1B2 PRKAA22 TSSK62 TSSK32 PRKAA12 MELK2 TSSK22 TSSK42
- STK112
18/97 SIMAP similar genes for HUNK using alignment to 5 protein entries: HUNK_HUMAN (see all proteins)
(see all similar genes):MARK3 MARK2 RPS6KA5 MARK4 PRKAA1 DKFZp564L2416
SIK3 STK38L CHEK2 BRSK2 KIAA0999 MELK
NUAK1 STK33 RPS6KA2 PRKCH PSKH1 PRKCQ
HUNK for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for HUNK
PGOHUM00000243689
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Genomic Variants
for HUNK gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 21 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HUNK (33245628 - 33416946 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for HUNK
2 CNVs: 5161 4114
1 Indel: 46157 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HUNK |
|
Disorders
/ Diseases
for HUNK gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HUNK for disorders About GeneDecksing
OMIM gene information: 606532
OMIM disorders: --
7  diseases for HUNK: About MalaCardsseptic arthritis vitiligo breast carcinoma arthritis
schizophrenia carcinoma alcoholism
Human Genome Epidemiology (HuGE) Navigator: HUNK (2 documents)
Export disorders for HUNK gene to outside databases
|
Publications
for HUNK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HUNK gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with HUNK) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PubMed id 17203973)1, 2 Vasilescu J.... Figeys D. (2007)
- The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 3 Hattori M....Yaspo M.L. (2000)
- Cloning and characterization of Hunk, a novel mammalian SNF1-related protein kinase. (PubMed id 10662544)1, 3 Gardner H.P....Chodosh L.A. (2000)
- HUNK suppresses metastasis of basal type breast cance rs by disrupting the interaction between PP2A and cofilin-1. (PubMed id 20133759)1, 9 Quintela-Fandino M....Mak T.W. (2010)
- Proteomics strategy to identify substrates of LNX, a P DZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (2012)
- Hunk is required for HER2/neu-induced mammary tumorig enesis. (PubMed id 21393859)1 Yeh E.S....Chodosh L.A. (2011)
- Genome-wide pharmacogenomic study of neurocognition a s an indicator of antipsychotic treatment response in schizophrenia. (PubMed id 21107309)1 McClay J.L....van den Oord E.J. (2011)
- Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. (PubMed id 21490949)1 Sim X....Tai E.S. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Genome-Wide Association Study of Generalized Vitiligo in an Isolated European Founder Population Identifies SMOC2, in Close Proximit y to IDDM8. (PubMed id 19890347)1 Birlea S.A....Spritz R.A. (2010)
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External Searches for HUNK gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HUNK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HUNK gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HUNK gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HUNK | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HUNK gene:
Search GeneIP for patents involving HUNK
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HUNK gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HUNK | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HUNK | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HUNK | | | OriGene Protein Over-expression Lysate for HUNK | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HUNK | | OriGene 3'-UTR Clone for HUNK | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HUNK | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HUNK | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HUNK | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HUNK | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HUNK | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HUNK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HUNK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HUNK |
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| |  |  |  |  | | | | |
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 | | | HUNK Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HUNK |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HUNK |
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