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Aliases for HUNK Gene

Aliases for HUNK Gene

  • Hormonally Up-Regulated Neu-Associated Kinase 2 3 5
  • Hormonally Upregulated Neu-Associated Kinase 2 3
  • EC 4 61
  • B19 3 4
  • Hormonally Up-Regulated Neu Tumor-Associated Kinase 3
  • Hormonally Upregulated Neu Tumor-Associated Kinase 3
  • Serine/Threonine Protein Kinase MAK-V 3
  • Serine/Threonine-Protein Kinase MAK-V 4
  • EC 2.7.11 61
  • MAKV 4

External Ids for HUNK Gene

Previous GeneCards Identifiers for HUNK Gene

  • GC21P029823
  • GC21P032166
  • GC21P032167
  • GC21P033245
  • GC21P018704

Summaries for HUNK Gene

GeneCards Summary for HUNK Gene

HUNK (Hormonally Up-Regulated Neu-Associated Kinase) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MELK.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HUNK Gene

Genomics for HUNK Gene

Regulatory Elements for HUNK Gene

Enhancers for HUNK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21F031897 0.9 Ensembl ENCODE 12.3 +26.7 26682 5.9 PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 FOS MXD4 PPARG HUNK HUNK-AS1
GH21F031892 0.8 Ensembl ENCODE 12.1 +21.2 21224 4.5 PKNOX1 ZFP64 ARID4B SIN3A ZNF48 GLIS2 ZNF143 ZNF207 KLF13 KDM4B HUNK HUNK-AS1
GH21F031907 0.8 Ensembl ENCODE 11.6 +35.8 35780 2.6 SOX13 TAL1 CEBPG ZIC2 ZNF644 ZFHX2 POLR2A SCRT2 ZNF600 EGR2 HUNK HUNK-AS1
GH21F031911 0.2 ENCODE 11.6 +38.0 38029 0.2 ZNF639 BHLHE40 KLF17 TSHZ1 OSR2 ZFHX2 ZNF692 RBAK PRDM10 FOS HUNK HUNK-AS1
GH21F031823 0.6 FANTOM5 11.4 -50.0 -49959 0.2 HUNK TPT1P1 GC21M031793
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HUNK on UCSC Golden Path with GeneCards custom track

Promoters for HUNK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000612762 185 2201 MLX ZNF133 ZFP64 ARID4B GLI4 DMAP1 ZNF48 ZNF2 YY1 ZNF121

Genomic Location for HUNK Gene

31,873,315 bp from pter
32,044,633 bp from pter
171,319 bases
Plus strand

Genomic View for HUNK Gene

Genes around HUNK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HUNK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HUNK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HUNK Gene

Proteins for HUNK Gene

  • Protein details for HUNK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hormonally up-regulated neu tumor-associated kinase
    Protein Accession:

    Protein attributes for HUNK Gene

    714 amino acids
    Molecular mass:
    79686 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HUNK Gene

Selected DME Specific Peptides for HUNK Gene


Post-translational modifications for HUNK Gene

  • Ubiquitination at Lys 483
  • Modification sites at PhosphoSitePlus

Other Protein References for HUNK Gene

Domains & Families for HUNK Gene

Gene Families for HUNK Gene

Protein Domains for HUNK Gene

Suggested Antigen Peptide Sequences for HUNK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with HUNK: view

Function for HUNK Gene

Molecular function for HUNK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for HUNK Gene

Gene Ontology (GO) - Molecular Function for HUNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA,TAS --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with HUNK: view
genes like me logo Genes that share phenotypes with HUNK: view

Animal Models for HUNK Gene

MGI Knock Outs for HUNK:

Animal Model Products

  • Taconic Biosciences Mouse Models for HUNK

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HUNK Gene

Localization for HUNK Gene

Subcellular locations from

Jensen Localization Image for HUNK Gene COMPARTMENTS Subcellular localization image for HUNK gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for HUNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with HUNK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HUNK Gene

Pathways & Interactions for HUNK Gene

SuperPathways for HUNK Gene

No Data Available

Gene Ontology (GO) - Biological Process for HUNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction TAS 10662544
GO:0007275 multicellular organism development TAS 10662544
GO:0016310 phosphorylation IEA --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with HUNK: view

No data available for Pathways by source and SIGNOR curated interactions for HUNK Gene

Drugs & Compounds for HUNK Gene

(1) Drugs for HUNK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for HUNK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with HUNK: view

Transcripts for HUNK Gene

Unigene Clusters for HUNK Gene

Hormonally up-regulated Neu-associated kinase:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HUNK Gene

No ASD Table

Relevant External Links for HUNK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HUNK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HUNK Gene

mRNA differential expression in normal tissues according to GTEx for HUNK Gene

This gene is overexpressed in Pancreas (x4.0).

Protein differential expression in normal tissues from HIPED for HUNK Gene

This gene is overexpressed in Liver (57.3) and Ovary (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HUNK Gene

Protein tissue co-expression partners for HUNK Gene

NURSA nuclear receptor signaling pathways regulating expression of HUNK Gene:


SOURCE GeneReport for Unigene cluster for HUNK Gene:

genes like me logo Genes that share expression patterns with HUNK: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HUNK Gene

Orthologs for HUNK Gene

This gene was present in the common ancestor of animals.

Orthologs for HUNK Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HUNK 34 35
  • 99.16 (n)
(Bos Taurus)
Mammalia HUNK 34 35
  • 88.92 (n)
(Canis familiaris)
Mammalia HUNK 34 35
  • 88.47 (n)
(Rattus norvegicus)
Mammalia Hunk 34
  • 87.72 (n)
(Mus musculus)
Mammalia Hunk 34 16 35
  • 87.35 (n)
(Monodelphis domestica)
Mammalia HUNK 35
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia HUNK 35
  • 57 (a)
(Gallus gallus)
Aves HUNK 34 35
  • 69.96 (n)
(Anolis carolinensis)
Reptilia HUNK 35
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hunk 34
  • 67.9 (n)
Str.7077 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24322 34
(Danio rerio)
Actinopterygii hunk 35
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta trbl 35
  • 19 (a)
(Caenorhabditis elegans)
Secernentea DC2.7a 36
  • 39 (a)
nipi-3 35
  • 13 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.399 34
Species where no ortholog for HUNK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HUNK Gene

Gene Tree for HUNK (if available)
Gene Tree for HUNK (if available)

Paralogs for HUNK Gene

Paralogs for HUNK Gene Pseudogenes for HUNK Gene

genes like me logo Genes that share paralogs with HUNK: view

Variants for HUNK Gene

Sequence variations from dbSNP and Humsavar for HUNK Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1010673 -- 31,919,882(-) GGGAC(A/G)CATTT intron-variant
rs1010674 -- 31,919,758(-) TCCTC(A/G)TTGAC intron-variant
rs1010675 -- 31,919,727(-) CGCAC(A/G)TCCAT intron-variant
rs1016702 -- 31,891,556(-) aaaca(C/G)gatcc intron-variant
rs1016704 -- 31,892,182(+) atata(G/T)agaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HUNK Gene

Variant ID Type Subtype PubMed ID
esv1172635 CNV deletion 17803354
esv2060229 CNV deletion 18987734
esv2723338 CNV deletion 23290073
esv2723340 CNV deletion 23290073
esv2723341 CNV deletion 23290073
esv2758819 CNV loss 17122850
esv3450400 CNV insertion 20981092
esv3568155 CNV loss 25503493
esv3646872 CNV loss 21293372
esv998414 CNV deletion 20482838
nsv1066285 CNV gain 25217958
nsv1067151 CNV gain 25217958
nsv1071751 CNV deletion 25765185
nsv1123553 CNV deletion 24896259
nsv3492 CNV insertion 18451855
nsv472350 CNV novel sequence insertion 20440878
nsv510793 CNV deletion 20534489
nsv518119 CNV loss 19592680
nsv587365 CNV gain 21841781
nsv834081 CNV loss 17160897
nsv834082 CNV gain 17160897

Variation tolerance for HUNK Gene

Residual Variation Intolerance Score: 46.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.32; 88.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HUNK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HUNK Gene

Disorders for HUNK Gene

Relevant External Links for HUNK

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HUNK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HUNK Gene

Publications for HUNK Gene

  1. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. (PMID: 21490949) Sim X. … Tai E.S. (PLoS Genet. 2011) 3 46 64
  2. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PMID: 21107309) McClay J.L. … van den Oord E.J. (Neuropsychopharmacology 2011) 3 46 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1. (PMID: 20133759) Quintela-Fandino M. … Mak T.W. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 22 64
  5. Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8. (PMID: 19890347) Birlea S.A. … Spritz R.A. (J. Invest. Dermatol. 2010) 3 46 64

Products for HUNK Gene

Sources for HUNK Gene

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