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Aliases for HUNK Gene

Aliases for HUNK Gene

  • Hormonally Up-Regulated Neu-Associated Kinase 2 3 5
  • Hormonally Upregulated Neu-Associated Kinase 2 3
  • Serine/Threonine-Protein Kinase MAK-V 3 4
  • EC 2.7.11.1 4 63
  • B19 3 4
  • Hormonally Upregulated Neu Tumor-Associated Kinase 3
  • Serine/Threonine Protein Kinase MAK-V 3
  • EC 2.7.11 63
  • MAKV 4

External Ids for HUNK Gene

Previous GeneCards Identifiers for HUNK Gene

  • GC21P029823
  • GC21P032166
  • GC21P032167
  • GC21P033245
  • GC21P018704

Summaries for HUNK Gene

GeneCards Summary for HUNK Gene

HUNK (Hormonally Up-Regulated Neu-Associated Kinase) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is BRSK1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HUNK Gene

Genomics for HUNK Gene

Regulatory Elements for HUNK Gene

Enhancers for HUNK Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HUNK on UCSC Golden Path with GeneCards custom track

Promoters for HUNK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HUNK on UCSC Golden Path with GeneCards custom track

Genomic Location for HUNK Gene

Chromosome:
21
Start:
31,873,315 bp from pter
End:
32,044,633 bp from pter
Size:
171,319 bases
Orientation:
Plus strand

Genomic View for HUNK Gene

Genes around HUNK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HUNK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HUNK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HUNK Gene

Proteins for HUNK Gene

  • Protein details for HUNK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57058-HUNK_HUMAN
    Recommended name:
    Hormonally up-regulated neu tumor-associated kinase
    Protein Accession:
    P57058

    Protein attributes for HUNK Gene

    Size:
    714 amino acids
    Molecular mass:
    79686 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HUNK Gene

Proteomics data for HUNK Gene at MOPED

Selected DME Specific Peptides for HUNK Gene

Post-translational modifications for HUNK Gene

  • Ubiquitination at Lys 483
  • Modification sites at PhosphoSitePlus

Other Protein References for HUNK Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for HUNK Gene

Gene Families for HUNK Gene

Suggested Antigen Peptide Sequences for HUNK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P57058

UniProtKB/Swiss-Prot:

HUNK_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with HUNK: view

Function for HUNK Gene

Molecular function for HUNK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for HUNK Gene

Gene Ontology (GO) - Molecular Function for HUNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with HUNK: view
genes like me logo Genes that share phenotypes with HUNK: view

Animal Models for HUNK Gene

MGI Knock Outs for HUNK:

Animal Model Products

  • Taconic Biosciences Mouse Models for HUNK

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HUNK Gene

Localization for HUNK Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HUNK Gene COMPARTMENTS Subcellular localization image for HUNK gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HUNK Gene

Pathways & Interactions for HUNK Gene

SuperPathways for HUNK Gene

No Data Available

Gene Ontology (GO) - Biological Process for HUNK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction TAS 10662544
GO:0007275 multicellular organism development TAS 10662544
genes like me logo Genes that share ontologies with HUNK: view

No data available for Pathways by source and SIGNOR curated interactions for HUNK Gene

Drugs & Compounds for HUNK Gene

(1) Drugs for HUNK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for HUNK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with HUNK: view

Transcripts for HUNK Gene

Unigene Clusters for HUNK Gene

Hormonally up-regulated Neu-associated kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HUNK Gene

No ASD Table

Relevant External Links for HUNK Gene

GeneLoc Exon Structure for
HUNK
ECgene alternative splicing isoforms for
HUNK

Expression for HUNK Gene

mRNA expression in normal human tissues for HUNK Gene

mRNA differential expression in normal tissues according to GTEx for HUNK Gene

This gene is overexpressed in Pancreas (x4.0).

Protein differential expression in normal tissues from HIPED for HUNK Gene

This gene is overexpressed in Liver (57.3) and Ovary (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HUNK Gene



SOURCE GeneReport for Unigene cluster for HUNK Gene Hs.109437

genes like me logo Genes that share expression patterns with HUNK: view

Protein tissue co-expression partners for HUNK Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HUNK Gene

Orthologs for HUNK Gene

This gene was present in the common ancestor of animals.

Orthologs for HUNK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HUNK 35
  • 88.92 (n)
  • 92.35 (a)
HUNK 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HUNK 35
  • 88.47 (n)
  • 90.63 (a)
HUNK 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hunk 35
  • 87.35 (n)
  • 92.44 (a)
Hunk 16
Hunk 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HUNK 35
  • 99.16 (n)
  • 99.72 (a)
HUNK 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hunk 35
  • 87.72 (n)
  • 92.16 (a)
oppossum
(Monodelphis domestica)
Mammalia HUNK 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HUNK 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves HUNK 35
  • 69.96 (n)
  • 69.06 (a)
HUNK 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HUNK 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hunk 35
  • 67.9 (n)
  • 66.91 (a)
Str.7077 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24322 35
zebrafish
(Danio rerio)
Actinopterygii hunk 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta trbl 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea DC2.7a 37
  • 39 (a)
nipi-3 36
  • 13 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.399 35
Species with no ortholog for HUNK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HUNK Gene

ENSEMBL:
Gene Tree for HUNK (if available)
TreeFam:
Gene Tree for HUNK (if available)

Paralogs for HUNK Gene

Paralogs for HUNK Gene

Pseudogenes.org Pseudogenes for HUNK Gene

genes like me logo Genes that share paralogs with HUNK: view

Variants for HUNK Gene

Sequence variations from dbSNP and Humsavar for HUNK Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs35133981 - 31,924,675(+) AGAAG(C/T)GGCTG reference, missense
rs10775648 - 31,998,810(+) TGGCT(C/T)GCAGA reference, missense
rs56021554 - 31,998,912(+) CTCAC(A/G)AAGAT reference, missense
rs56240027 - 31,998,982(+) CCCCA(C/T)GCAGC reference, missense
rs1106541 -- 31,977,793(-) gatgg(C/T)ttgag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HUNK Gene

Variant ID Type Subtype PubMed ID
nsv834081 CNV Loss 17160897
nsv834082 CNV Gain 17160897
nsv510793 CNV Loss 20534489
dgv1372e1 CNV Complex 17122850
nsv913680 CNV Gain 21882294
esv2723338 CNV Deletion 23290073
esv2060229 CNV Deletion 18987734
esv2723340 CNV Deletion 23290073
esv998414 CNV Deletion 20482838
esv1172635 CNV Deletion 17803354
nsv3492 CNV Insertion 18451855
esv2723341 CNV Deletion 23290073
nsv518119 CNV Loss 19592680

Variation tolerance for HUNK Gene

Residual Variation Intolerance Score: 46.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.32; 88.30% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HUNK Gene

Disorders for HUNK Gene

Relevant External Links for HUNK

Genetic Association Database (GAD)
HUNK
Human Genome Epidemiology (HuGE) Navigator
HUNK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HUNK

No disorders were found for HUNK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HUNK Gene

Publications for HUNK Gene

  1. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PMID: 21107309) McClay J.L. … van den Oord E.J. (Neuropsychopharmacology 2011) 3 48 67
  2. HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1. (PMID: 20133759) Quintela-Fandino M. … Mak T.W. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 23
  3. Cloning and characterization of Hunk, a novel mammalian SNF1-related protein kinase. (PMID: 10662544) Gardner H.P. … Chodosh L.A. (Genomics 2000) 2 3
  4. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 2 3
  5. Regulation of cell survival by HUNK mediates breast cancer resistance to HER2 inhibitors. (PMID: 25515931) Yeh E.S. … Hill E.G. (Breast Cancer Res. Treat. 2015) 3

Products for HUNK Gene

Sources for HUNK Gene

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