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Aliases for HULC Gene

Subcategory (RNA class) for HULC Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for HULC Gene

  • Hepatocellular Carcinoma Up-Regulated Long Non-Coding RNA 2 3 5
  • Hepatocellular Carcinoma Associated Transcript 1 (Non-Protein Coding) 2 3
  • Highly Up-Regulated In Liver Cancer Long Non-Coding RNA 2 3
  • Long Intergenic Non-Protein Coding RNA 78 2 3
  • Highly Up-Regulated In Liver Cancer (Non-Protein Coding) 3
  • Non-Protein Coding RNA 78 2
  • NCRNA00078 3
  • LINC00078 3
  • HCCAT1 3

External Ids for HULC Gene

Previous GeneCards Identifiers for HULC Gene

  • GC06P008598

Summaries for HULC Gene

GeneCards Summary for HULC Gene

HULC (Hepatocellular Carcinoma Up-Regulated Long Non-Coding RNA) is an RNA Gene, and is affiliated with the non-coding RNA class.

Gene Wiki entry for HULC Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HULC Gene

Genomics for HULC Gene

Regulatory Elements for HULC Gene

Enhancers for HULC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G008626 0.6 ENCODE 0.3 -24.3 -24277 2.2 JUND IKZF1 CREB1 U2AF2 IKZF2 ATF2 TCF7L2 LOC100506207 GC06P008626 HULC
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HULC on UCSC Golden Path with GeneCards custom track

Genomic Location for HULC Gene

Chromosome:
6
Start:
8,652,137 bp from pter
End:
8,653,846 bp from pter
Size:
1,710 bases
Orientation:
Plus strand

Genomic View for HULC Gene

Genes around HULC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HULC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HULC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HULC Gene

Proteins for HULC Gene

Post-translational modifications for HULC Gene

No Post-translational modifications

No data available for DME Specific Peptides for HULC Gene

Domains & Families for HULC Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HULC: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for HULC Gene

Function for HULC Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HULC Gene

Localization for HULC Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for HULC Gene

Pathways & Interactions for HULC Gene

No Data Available

Interacting Proteins for HULC Gene

Gene Ontology (GO) - Biological Process for HULC Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HULC Gene

Drugs & Compounds for HULC Gene

No Compound Related Data Available

Transcripts for HULC Gene

mRNA/cDNA for HULC Gene

(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HULC Gene

Highly up-regulated in liver cancer long non-coding RNA:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HULC Gene

No ASD Table

Relevant External Links for HULC Gene

GeneLoc Exon Structure for
HULC
ECgene alternative splicing isoforms for
HULC

Expression for HULC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HULC Gene

mRNA differential expression in normal tissues according to GTEx for HULC Gene

This gene is overexpressed in Liver (x49.9).

NURSA nuclear receptor signaling pathways regulating expression of HULC Gene:

HULC

SOURCE GeneReport for Unigene cluster for HULC Gene:

Hs.214343
genes like me logo Genes that share expression patterns with HULC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HULC Gene

Orthologs for HULC Gene

Evolution for HULC Gene

ENSEMBL:
Gene Tree for HULC (if available)
TreeFam:
Gene Tree for HULC (if available)

No data available for Orthologs for HULC Gene

Paralogs for HULC Gene

No data available for Paralogs for HULC Gene

Variants for HULC Gene

Sequence variations from dbSNP and Humsavar for HULC Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000073093 -- 8,652,583(+) GTTCG(A/T)ACAAT intron-variant
rs1001312611 -- 8,651,981(+) GAGGT(A/G)TGGGA intron-variant, upstream-variant-2KB
rs1003655709 -- 8,650,505(+) TTAAG(A/C)TAAAC intron-variant, upstream-variant-2KB
rs1004571404 -- 8,650,387(+) TAACT(A/G)TACTG intron-variant, upstream-variant-2KB
rs1004953032 -- 8,651,486(+) CAAAC(A/G)TTTAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HULC Gene

Variant ID Type Subtype PubMed ID
dgv10293n54 CNV loss 21841781
dgv5915n100 CNV loss 25217958
esv2763945 CNV loss 21179565
esv3570761 CNV loss 25503493
esv3608034 CNV loss 21293372
esv3608036 CNV loss 21293372
nsv1133014 OTHER inversion 24896259
nsv1151332 OTHER inversion 26484159
nsv600927 CNV gain 21841781

Relevant External Links for HULC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HULC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HULC Gene

Disorders for HULC Gene

Relevant External Links for HULC

Genetic Association Database (GAD)
HULC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HULC

No disorders were found for HULC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HULC Gene

Publications for HULC Gene

  1. Posttranscriptional destabilization of the liver-specific long noncoding RNA HULC by the IGF2 mRNA-binding protein 1 (IGF2BP1). (PMID: 23728852) HAommerle M. … Diederichs S. (Hepatology 2013) 2 3 64
  2. Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA. (PMID: 17241883) Panzitt K. … Zatloukal K. (Gastroenterology 2007) 2 3 64
  3. Long noncoding RNA HULC promotes cell proliferation by regulating PI3K/AKT signaling pathway in chronic myeloid leukemia. (PMID: 28069548) Lu Y. … Wang J. (Gene 2017) 3 64
  4. Long non-coding RNA ATB promotes growth and epithelial-mesenchymal transition and predicts poor prognosis in human prostate carcinoma. (PMID: 27176634) Xu S. … Zhou W.Q. (Oncol. Rep. 2016) 3 64
  5. miR-203 suppresses the proliferation and metastasis of hepatocellular carcinoma by targeting oncogene ADAM9 and oncogenic long non-coding RNA HULC. (PMID: 26179263) Wan D. … Peng B. (Anticancer Agents Med Chem 2016) 3 64

Products for HULC Gene

Sources for HULC Gene

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