Aliases for HTRA4 Gene
External Ids for HTRA4 Gene
Previous GeneCards Identifiers for HTRA4 Gene
This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging. [provided by RefSeq, Oct 2008]
GeneCards Summary for HTRA4 Gene
HTRA4 (HtrA Serine Peptidase 4) is a Protein Coding gene. Diseases associated with HTRA4 include pre-eclampsia. GO annotations related to this gene include serine-type endopeptidase activity and insulin-like growth factor binding. An important paralog of this gene is HTRA3.
UniProtKB/Swiss-Prot for HTRA4 Gene