Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HTRA4 Gene

protein-coding   GIFtS: 46
GCID: GC08P038831

HtrA Serine Peptidase 4

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
HtrA Serine Peptidase 41 2     EC 3.4.21.-3
High-Temperature Requirement Factor A42 3     EC 3.4.218
Probable Serine Protease HTRA42     EC 3.4.21.1088
Serine Protease HTRA42     

External Ids:    HGNC: 269091   Entrez Gene: 2031002   Ensembl: ENSG000001694957   OMIM: 6107005   UniProtKB: P831053   

Export aliases for HTRA4 gene to outside databases

Previous GC identifers: GC08P038951 GC08P037364


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HTRA4 Gene:
This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal
peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain
and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted
oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been
implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging. (provided by RefSeq,
Oct 2008)

GeneCards Summary for HTRA4 Gene: 
HTRA4 (HtrA serine peptidase 4) is a protein-coding gene. Diseases associated with HTRA4 include severe pre-eclampsia, and pre-eclampsia. GO annotations related to this gene include insulin-like growth factor binding and serine-type endopeptidase activity. An important paralog of this gene is HTRA1.

UniProtKB/Swiss-Prot: HTRA4_HUMAN, P83105
Function: Serine protease (Probable)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_167187.1  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HTRA4 gene promoter:
         GR   USF1   AML1a   GR-beta   LUN-1   PPAR-gamma1   S8   USF-1   PPAR-gamma2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHTRA4 promoter sequence
   Search SABiosciences Chromatin IP Primers for HTRA4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTRA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.22   Ensembl cytogenetic band:  8p11.22   HGNC cytogenetic band: 8p11.23

HTRA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTRA4 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P038831:  view genomic region     (about GC identifiers)

Start:
38,831,668 bp from pter      End:
38,846,181 bp from pter
Size:
14,514 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HTRA4_HUMAN, P83105 (See protein sequence)
Recommended Name: Serine protease HTRA4 precursor  
Size: 476 amino acids; 50979 Da
Subcellular location: Secreted (By similarity)
Secondary accessions: Q542Z4 Q6PF13

Explore the universe of human proteins at neXtProt for HTRA4: NX_P83105

Explore proteomics data for HTRA4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P83105

  • 2 DME Specific Peptides for HTRA4 (P83105)
     GNSGGPL  GFIVSEDG 

    HTRA4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HTRA4 Protein Expression
    REFSEQ proteins: NP_710159.1  
    ENSEMBL proteins: 
     ENSP00000305919  

    Human Recombinant Protein Products for HTRA4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HTRA4
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for HTRA4
    GenScript Custom Purified and Recombinant Proteins Services for HTRA4
    Novus Biologicals HTRA4 Protein
    Novus Biologicals HTRA4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HTRA4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    HTRA4 for ontologies           About GeneDecksing



    HTRA4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HTRA4
    GenScript Custom Superior Antibodies Services for HTRA4
    Novus Biologicals HTRA4 Antibodies
    Abcam antibodies for HTRA4
    Cloud-Clone Corp. Antibodies for HTRA4 
    Search ThermoFisher Antibodies for HTRA4
    LSBio Antibodies in human, mouse, rat for HTRA4 

    Assay Products for HTRA4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HTRA4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HTRA4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HTRA4 
    Cloud-Clone Corp. CLIAs for HTRA4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR002350 Kazal_dom
     IPR001940 Peptidase_S1C
     IPR000867 IGFBP-like
     IPR001478 PDZ
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry P83105

    ProtoNet protein and cluster: P83105

    2 Blocks protein domains:
    IPB001478 PDZ/DHR/GLGF domain
    IPB001940 HtrA/DegQ protease family signature


    UniProtKB/Swiss-Prot: HTRA4_HUMAN, P83105
    Similarity: Belongs to the peptidase S1B family
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 1 Kazal-like domain
    Similarity: Contains 1 PDZ (DHR) domain


    HTRA4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HTRA4_HUMAN, P83105
    Function: Serine protease (Probable)

         Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.1082 EC 3.4.21.-1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004175endopeptidase activity IDA18387192
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0005515protein binding ----
    GO:0005520insulin-like growth factor binding IEA--
         
    HTRA4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HTRA4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HTRA4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HTRA4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HTRA4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HTRA4
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate HTRA4:
    hsa-miR-1271 hsa-miR-96
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HTRA4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HTRA4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HTRA4
    Sirion Biotech Customized adenovirus for overexpression of HTRA4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for HTRA4 (see all 7)
    OriGene ORF clones in mouse, rat for HTRA4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HTRA4 (NM_153692)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTRA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTRA4
    Sirion Biotech Customized lentivirus for stable overexpression of HTRA4 
                         Customized lentivirus expression plasmids for stable overexpression of HTRA4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HTRA4
    Search LifeMap BioReagents cell lines for HTRA4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTRA4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HTRA4

    1 Interacting protein for HTRA4 (P831053) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XIAPP981703I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0006508proteolysis IDA18387192
    GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway ISS--

    HTRA4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HTRA4

    Search CenterWatch for drugs/clinical trials and news about HTRA4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HTRA4 gene: 
    NM_153692.3  

    Unigene Cluster for HTRA4:

    HtrA serine peptidase 4
    Hs.661014  [show with all ESTs]
    Unigene Representative Sequence: NM_153692
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000302495(uc003xmj.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HTRA4
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate HTRA4:
    hsa-miR-1271 hsa-miR-96
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HTRA4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HTRA4
    Clone
    Products:
         
    OriGene clones in human, mouse for HTRA4 (see all 7)
    OriGene ORF clones in mouse, rat for HTRA4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HTRA4 (NM_153692)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTRA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTRA4
    Sirion Biotech Customized lentivirus for stable overexpression of HTRA4 
                         Customized lentivirus expression plasmids for stable overexpression of HTRA4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HTRA4
    OriGene qSTAR qPCR primer pairs in human, mouse for HTRA4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HTRA4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HTRA4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTRA4

    Additional mRNA sequence: 

    AK075205.1 AK300197.1 AY188774.1 BC057765.1 

    3 DOTS entries:

    DT.91711356  DT.100749850  DT.100757840 

    24/30 AceView cDNA sequences (see all 30):

    AL553302 CR590249 CR601506 AL545759 AK075205 BU753896 AL576444 AL551947 
    CB961876 NM_153692 BX416892 CB961875 AY188774 BX451410 BX380962 CB991519 
    AL551062 BQ011847 BC057765 AL551918 AL574735 BX358760 CB959959 CB997220 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HTRA4 expression in normal human tissues (normalized intensities)      HTRA4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACACATTT
    HTRA4 Expression
    About this image


    HTRA4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             gastrocnemius muscle   
     
     Ovary (Reproductive System)
             oocyte   
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
     
     Placenta (Extraembryonic Tissues)

    See HTRA4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HTRA4

    SOURCE GeneReport for Unigene cluster: Hs.661014
        SABiosciences Expression via Pathway-Focused PCR Arrays including HTRA4: 
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HTRA4
    OriGene qSTAR qPCR primer pairs in human, mouse for HTRA4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HTRA4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HTRA4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTRA4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTRA4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HTRA4 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Htra41 , 5 HtrA serine peptidase 41, 5 75.9(n)1
    68.18(a)1
      8 (13.70 cM)5
    3307231  NM_001081187.31  NP_001074656.11 
     250254515 
    lizard
    (Anolis carolinensis)
    Reptilia HTRA46
    Uncharacterized protein
    61(a)
    1 ↔ 1
    GL343418.1(535130-540485)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003342571 serine protease HTRA1-like 58.64(n)
    55.56(a)
      100334257  XM_002662005.2  XP_002662051.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta HtrA26
    HtrA2
    36(a)
    1 → many
    3R(10334771-10337434)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NMA1116
    Serine protease and general molecular chaperone; i...
    8(a)
    1 → many
    XIV(394685-397678)


    ENSEMBL Gene Tree for HTRA4 (if available)
    TreeFam Gene Tree for HTRA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HTRA4 gene
    HTRA12  HTRA22  HTRA32  
    3 SIMAP similar genes for HTRA4 using alignment to 1 protein entry:     HTRA4_HUMAN:
    HTRA1    HTRA3    HTRA2

    HTRA4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/329 SNPs in HTRA4 are shown (see all 329)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1483206901,2
    C--38832210(+) GGTCCC/GGGCCG 2 P R mis10--------
    rs1144823811,2
    C,F--38832547(+) TTTCAT/CAGGGA 1 -- int11Minor allele frequency- C:0.03WA 118
    rs1442661911,2
    C,F--38832564(+) GCGCAG/AGCCCG 2 /S /G mis11Minor allele frequency- A:0.00NA 4552
    rs1462420511,2
    C--38832607(+) GGTGGA/TGAAGG 2 E V mis10--------
    rs1165290311,2
    C,F--38832610(+) GGAGAA/TGGTGG 2 K M mis11Minor allele frequency- T:0.00NA 4552
    rs765102161,2
    C--38832628(+) GGTGGG/TTCACG 2 G V mis10--------
    rs1412540361,2
    C,F--38832634(+) TCACGT/CGCAGC 2 /A /V mis11Minor allele frequency- C:0.00NA 4552
    rs2019763441,2
    C--38832683(+) GTCCCA/C/GGCTAA 1 -- int10--------
    rs2015473871,2
    C--38832741(+) AATCC-/AAAAAA 1 -- int10--------
    rs1381613451,2
    --38832775(+) AAGAGA/GTTGAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for HTRA4 (38831668 - 38846181 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HTRA4: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HTRA4
    DNA2.0 Custom Variant and Variant Library Synthesis for HTRA4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610700    OMIM disorders: --

    7 diseases for HTRA4:    About MalaCards
    severe pre-eclampsia    pre-eclampsia    eclampsia    leprosy
    arthritis    pneumonia    tuberculosis


    HTRA4 for disorders           About GeneDecksing


    Export disorders for HTRA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HTRA4 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with HTRA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Upregulation of HtrA4 in the placentas of patients wit h severe pre-eclampsia. (PubMed id 22964307)1 Inagaki A....Udagawa Y. (2012)
    4. High-temperature requirement protein A4 (HtrA4) suppre sses the fusogenic activity of syncytin-1 and promotes trophoblast invasion. (PubMed id 22778138)1 Wang L.J....Chen H. (2012)
    5. A pathway sensor for genome-wide screens of intracellu lar proteolytic cleavage. (PubMed id 18387192)1 Ketteler R....Seed B. (2008)
    6. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
    7. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (2005)
    8. The HtrA family of proteases: implications for protein composition and cell fate. (PubMed id 12408815)1 Clausen T....Ehrmann M. (2002)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Pattern of expression of HtrA1 during mouse development. (PubMed id 15557215)9 De Luca A....Baldi A. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 203100 HGNC: 26909 AceView: FLJ90724 Ensembl:ENSG00000169495 euGenes: HUgn203100
    ECgene: HTRA4 H-InvDB: HTRA4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HTRA4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HTRA4 gene:
    Search GeneIP for patents involving HTRA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HTRA4  
     OriGene qPCR primer pairs and template standards for HTRA4   OriGene Protein Over-expression Lysate for HTRA4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HTRA4  
     OriGene qSTAR qPCR primer pairs in human, mouse for HTRA4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for HTRA4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HTRA4   OriGene Custom Protein Services for HTRA4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HTRA4
     QIAGEN SeqTarget long-range PCR primers for resequencing HTRA4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTRA4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HTRA4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTRA4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HTRA4
     GenScript Custom Purified and Recombinant Proteins Services for HTRA4 GenScript cDNA clones with any tag delivered in your preferred vector for HTRA4
     GenScript Custom Assay Services for HTRA4 GenScript Custom Superior Antibodies Services for HTRA4
     GenScript Custom overexpressing Cell Line Services for HTRA4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HTRA4 promoter
     Search Chromatin IP Primers for HTRA4
     RT2 qPCR Primer Assay in human, mouse, rat HTRA4
     Search GNC Networks for HTRA4
     SABiosciences PCR Arrays including human, mouse, rat HTRA4
     Search Tocris compounds for HTRA4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HTRA4 antibodies
     HTRA4 proteins
     HTRA4 lysates
     Antibodies for HTRA4
     See all of Abcam's Antibodies, Kits and Proteins for HTRA4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for HTRA4
     Antibodies for HTRA4
     ELISAs for HTRA4
     CLIAs for HTRA4
     Search LifeMap BioReagents cell lines for HTRA4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTRA4
     Browse SwitchGear 3'UTR luciferase reporter plasmids for HTRA4
     SwitchGear Promoter luciferase reporter plasmids for HTRA4
     Search ThermoFisher Antibodies for HTRA4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTRA4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for HTRA4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HTRA4
    Customized:
     lentivirus for stable overexpression of HTRA4
     lentivirus expression plasmids for stable overexpression of HTRA4
     adenovirus for overexpression of HTRA4
     LSBio Antibodies in human, mouse, rat for HTRA4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HTRA4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4