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HTRA4 Gene

protein-coding   GIFtS: 47
GCID: GC08P038831

HtrA Serine Peptidase 4

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
HtrA Serine Peptidase 41 2     EC 3.4.21.-3
High-Temperature Requirement Factor A42 3     EC 3.4.218
Probable Serine Protease HTRA42     EC 3.4.21.1088
Serine Protease HTRA42     

External Ids:    HGNC: 269091   Entrez Gene: 2031002   Ensembl: ENSG000001694957   OMIM: 6107005   UniProtKB: P831053   

Export aliases for HTRA4 gene to outside databases

Previous GC identifers: GC08P038951 GC08P037364


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HTRA4 Gene:
This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal
peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain
and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted
oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been
implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging. (provided by RefSeq,
Oct 2008)

GeneCards Summary for HTRA4 Gene:
HTRA4 (HtrA serine peptidase 4) is a protein-coding gene. Diseases associated with HTRA4 include severe pre-eclampsia, and eclampsia. GO annotations related to this gene include insulin-like growth factor binding and serine-type endopeptidase activity. An important paralog of this gene is HTRA1.

UniProtKB/Swiss-Prot: HTRA4_HUMAN, P83105
Function: Serine protease (Probable)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HTRA4 gene promoter:
         GR   USF1   AML1a   GR-beta   LUN-1   PPAR-gamma1   S8   USF-1   PPAR-gamma2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHTRA4 promoter sequence
   Search Chromatin IP Primers for HTRA4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HTRA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.22   Ensembl cytogenetic band:  8p11.22   HGNC cytogenetic band: 8p11.23

HTRA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTRA4 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P038831:  view genomic region     (about GC identifiers)

Start:
38,831,668 bp from pter      End:
38,846,181 bp from pter
Size:
14,514 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HTRA4_HUMAN, P83105 (See protein sequence)
Recommended Name: Serine protease HTRA4 precursor  
Size: 476 amino acids; 50979 Da
Secondary accessions: Q542Z4 Q6PF13

Explore the universe of human proteins at neXtProt for HTRA4: NX_P83105

Explore proteomics data for HTRA4 at MOPED

2 DME Specific Peptides for HTRA4 (P83105)
 GNSGGPL  GFIVSEDG 


See HTRA4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_710159.1  
ENSEMBL proteins: 
 ENSP00000305919  

HTRA4 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for HTRA4
OriGene Custom MassSpec
OriGene Custom Protein Services for HTRA4
GenScript Custom Purified and Recombinant Proteins Services for HTRA4
Novus Biologicals HTRA4 Protein
Novus Biologicals HTRA4 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for HTRA4

HTRA4 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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Browse OriGene Antibodies
OriGene Custom Antibody Services for HTRA4
Novus Biologicals HTRA4 Antibodies
Abcam antibodies for HTRA4
Cloud-Clone Corp. Antibodies for HTRA4
Search ThermoFisher Antibodies for HTRA4
LSBio Antibodies in human, mouse, rat for HTRA4

HTRA4 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for HTRA4
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for HTRA4
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for HTRA4
Cloud-Clone Corp. CLIAs for HTRA4


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Selected InterPro protein domains (see all 6):
 IPR002350 Kazal_dom
 IPR001940 Peptidase_S1C
 IPR000867 IGFBP-like
 IPR001478 PDZ
 IPR009030 Growth_fac_rcpt_N_dom

Graphical View of Domain Structure for InterPro Entry P83105

ProtoNet protein and cluster: P83105

2 Blocks protein domains:
IPB001478 PDZ/DHR/GLGF domain
IPB001940 HtrA/DegQ protease family signature


UniProtKB/Swiss-Prot: HTRA4_HUMAN, P83105
Similarity: Belongs to the peptidase S1B family
Similarity: Contains 1 IGFBP N-terminal domain
Similarity: Contains 1 Kazal-like domain
Similarity: Contains 1 PDZ (DHR) domain


HTRA4 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: HTRA4_HUMAN, P83105
Function: Serine protease (Probable)

     Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.1082 EC 3.4.21.-1

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003824catalytic activity ----
GO:0004175endopeptidase activity IDA18387192
GO:0004252serine-type endopeptidase activity IEA--
GO:0005515protein binding ----
GO:0005520insulin-like growth factor binding IEA--
     
HTRA4 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HTRA4
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HTRA4

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HTRA4
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HTRA4

miRNA
Products:
    
miRTarBase miRNAs that target HTRA4:
hsa-mir-7-5p (MIRT025641), hsa-mir-128-3p (MIRT021941), hsa-mir-335-5p (MIRT017453)

Block miRNA regulation of human, mouse, rat HTRA4 using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate HTRA4:
hsa-miR-1271 hsa-miR-96
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for HTRA4
Predesigned siRNA for gene silencing in human, mouse, rat HTRA4

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for HTRA4

Clone
Products:
     
OriGene clones in human, mouse for HTRA4 (see all 6)
OriGene ORF clones in mouse, rat for HTRA4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HTRA4 (NM_153692)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTRA4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTRA4

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for HTRA4
Browse ESI BIO Cell Lines and PureStem Progenitors for HTRA4 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTRA4


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
HTRA4_HUMAN, P83105: Secreted (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular2
lysosome1
peroxisome1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

HTRA4 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathway & Disease-focused RT2 Profiler PCR Arrays including HTRA4: 
          Unfolded Protein Response in human mouse rat
          Molecular Toxicology PathwayFinder 384HT in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for HTRA4

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

Selected Interacting proteins for HTRA4 (P831053 ENSP000003059194) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
InteractantInteraction Details
GeneCardExternal ID(s)
XIAPP981703I2D: score=1 
PSMD3ENSP000002646394STRING: ENSP00000264639
PSMD12ENSP000003484424STRING: ENSP00000348442
HSPB1ENSP000002485534STRING: ENSP00000248553
COPS2ENSP000002992594STRING: ENSP00000299259
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001558regulation of cell growth IEA--
GO:0006508proteolysis IDA18387192
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway ISS--

HTRA4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for HTRA4



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for HTRA4 gene: 
NM_153692.3  

Unigene Cluster for HTRA4:

HtrA serine peptidase 4
Hs.661014  [show with all ESTs]
Unigene Representative Sequence: NM_153692
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000302495(uc003xmj.3)
Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat HTRA4 using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate HTRA4:
hsa-miR-1271 hsa-miR-96
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for HTRA4
Predesigned siRNA for gene silencing in human, mouse, rat HTRA4
Clone
Products:
     
OriGene clones in human, mouse for HTRA4 (see all 6)
OriGene ORF clones in mouse, rat for HTRA4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HTRA4 (NM_153692)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTRA4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTRA4
Primer
Products:
    
OriGene qPCR primer pairs and template standards for HTRA4
OriGene qSTAR qPCR primer pairs in human, mouse for HTRA4
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HTRA4
  QuantiTect SYBR Green Assays in human, mouse, rat HTRA4
  QuantiFast Probe-based Assays in human, mouse, rat HTRA4

Additional mRNA sequence: 

AK075205.1 AK300197.1 AY188774.1 BC057765.1 

3 DOTS entries:

DT.91711356  DT.100749850  DT.100757840 

Selected AceView cDNA sequences (see all 30):

CR590249 CR601506 AL553302 AL576444 AL551947 CB961875 AL551918 BC057765 
BX451410 AL551062 BU753896 AK075205 AY188774 BX380962 BQ011847 AL545759 
BX416892 NM_153692 CB961876 CB991519 BX358760 AL574735 AL545720 CB959959 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HTRA4 expression in normal human tissues (normalized intensities)      HTRA4 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCACACATTT
HTRA4 Expression
About this image


HTRA4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Testis (Reproductive System)
         Sertoli cells Seminiferous Tubules
 
 Placenta (Extraembryonic Tissues)
HTRA4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

HTRA4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.661014
    Pathway & Disease-focused RT2 Profiler PCR Arrays including HTRA4: 
          Unfolded Protein Response in human mouse rat
          Molecular Toxicology PathwayFinder 384HT in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for HTRA4
OriGene qSTAR qPCR primer pairs in human, mouse for HTRA4
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HTRA4
QuantiTect SYBR Green Assays in human, mouse, rat HTRA4
QuantiFast Probe-based Assays in human, mouse, rat HTRA4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTRA4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for HTRA4 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Htra41 , 5 HtrA serine peptidase 41, 5 76.17(n)1
68.37(a)1
  8 (13.70 cM)5
3307231  NM_001081187.31  NP_001074656.11 
 250254515 
lizard
(Anolis carolinensis)
Reptilia HTRA46
HtrA serine peptidase 4
60(a)
1 ↔ 1
GL343418.1(535130-540485)
tropical clawed frog
(Xenopus tropicalis)
Amphibia LOC1004886071 serine protease HTRA1-like 61.75(n)
58.06(a)
  100488607  XM_002932783.2  XP_002932829.1 
zebrafish
(Danio rerio)
Actinopterygii LOC1003342571 serine protease HTRA1-like 58.6(n)
55.3(a)
  100334257  XM_002662005.3  XP_002662051.2 
fruit fly
(Drosophila melanogaster)
Insecta HtrA26
HtrA2
37(a)
1 → many
3R(10334771-10337434)


ENSEMBL Gene Tree for HTRA4 (if available)
TreeFam Gene Tree for HTRA4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for HTRA4 gene
HTRA12  HTRA22  HTRA32  
3 SIMAP similar genes for HTRA4 using alignment to 1 protein entry:     HTRA4_HUMAN:
HTRA1    HTRA3    HTRA2

HTRA4 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for HTRA4 (see all 329)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1483206901,2
C--38832210(+) GGTCCC/GGGCCG 2 P R mis10--------
rs1144823811,2
C,F--38832547(+) TTTCAT/CAGGGA 1 -- int11Minor allele frequency- C:0.03WA 118
rs1442661911,2
C,F--38832564(+) GCGCAG/AGCCCG 2 /S /G mis11Minor allele frequency- A:0.00NA 4552
rs1462420511,2
C--38832607(+) GGTGGA/TGAAGG 2 E V mis10--------
rs1165290311,2
C,F--38832610(+) GGAGAA/TGGTGG 2 K M mis11Minor allele frequency- T:0.00NA 4552
rs765102161,2
C--38832628(+) GGTGGG/TTCACG 2 G V mis10--------
rs1412540361,2
C,F--38832634(+) TCACGT/CGCAGC 2 /A /V mis11Minor allele frequency- C:0.00NA 4552
rs2019763441,2
C--38832683(+) GTCCCA/C/GGCTAA 1 -- int10--------
rs2015473871,2
C--38832741(+) AATCC-/AAAAAA 1 -- int10--------
rs1381613451,2
--38832775(+) AAGAGA/GTTGAA 1 -- int10--------

HapMap Linkage Disequilibrium report for HTRA4 (38831668 - 38846181 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for HTRA4: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing HTRA4
DNA2.0 Custom Variant and Variant Library Synthesis for HTRA4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 610700    OMIM disorders: --

7 diseases for HTRA4:    About MalaCards
severe pre-eclampsia    eclampsia    pre-eclampsia    leprosy
arthritis    pneumonia    tuberculosis


HTRA4 for disorders           About GeneDecksing


Export disorders for HTRA4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for HTRA4 gene integrated from 10 sources:
(articles sorted by number of sources associating them with HTRA4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. Upregulation of HtrA4 in the placentas of patients with severe pre-eclampsia. (PubMed id 22964307)1 Inagaki A....Udagawa Y. (Placenta 2012)
  4. High-temperature requirement protein A4 (HtrA4) suppresses the fusogenic activity of syncytin-1 and promotes trophoblast invasion. (PubMed id 22778138)1 Wang L.J....Chen H. (Mol. Cell. Biol. 2012)
  5. A pathway sensor for genome-wide screens of intracellular proteolytic cleavage. (PubMed id 18387192)1 Ketteler R....Seed B. (Genome Biol. 2008)
  6. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (Nature 2006)
  7. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1 Otsuki T....Isogai T. (DNA Res. 2005)
  8. The HtrA family of proteases: implications for protein composition and cell fate. (PubMed id 12408815)1 Clausen T....Ehrmann M. (Mol. Cell 2002)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  10. Pattern of expression of HtrA1 during mouse development. (PubMed id 15557215)9 De Luca A....Baldi A. (J. Histochem. Cytochem. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 203100 HGNC: 26909 AceView: FLJ90724 Ensembl:ENSG00000169495 euGenes: HUgn203100
ECgene: HTRA4 H-InvDB: HTRA4

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for HTRA4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for HTRA4 gene:
Search GeneIP for patents involving HTRA4

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HTRA4  
 OriGene qPCR primer pairs and template standards for HTRA4   OriGene Protein Over-expression Lysate for HTRA4  
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 OriGene Custom Antibody Services for HTRA4   OriGene Custom Protein Services for HTRA4  

 
 
 Block miRNA regulation of human, mouse, rat HTRA4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HTRA4
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HTRA4 Predesigned siRNA for gene silencing in human, mouse, rat HTRA4
 QuantiFast Probe-based Assays in human, mouse, rat HTRA4 QuantiTect SYBR Green Assays in human, mouse, rat HTRA4
 PCR Arrays including human, mouse, rat HTRA4 Search Chromatin IP Primers for HTRA4
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HTRA4  Search GeneGlobe Interaction Network for HTRA4
 Regulatory tfbs in HTRA4 promoter
 GenScript Custom Purified and Recombinant Proteins Services for HTRA4 GenScript cDNA clones with any tag delivered in your preferred vector for HTRA4
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 Search Tocris compounds for HTRA4
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 Novus Tissue Slides
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 See all of Abcam's Antibodies, Kits and Proteins for HTRA4
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 Browse ProSpec Recombinant Proteins
 Proteins for HTRA4
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 Browse ESI BIO Cell Lines and PureStem Progenitors for HTRA4
 Gene Synthesis
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTRA4
 Browse SwitchGear 3'UTR luciferase reporter plasmids for HTRA4
 SwitchGear Promoter luciferase reporter plasmids for HTRA4
 Search ThermoFisher Antibodies for HTRA4
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTRA4
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HTRA4
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HTRA4
 LSBio Antibodies in human, mouse, rat for HTRA4
Customized transgenic rodents for:
 Humanization
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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