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Aliases for HTRA4 Gene

Aliases for HTRA4 Gene

  • HtrA Serine Peptidase 4 2 3
  • High-Temperature Requirement Factor A4 4
  • EC 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63

External Ids for HTRA4 Gene

Previous GeneCards Identifiers for HTRA4 Gene

  • GC08P038831
  • GC08P037364

Summaries for HTRA4 Gene

Entrez Gene Summary for HTRA4 Gene

  • This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging. [provided by RefSeq, Oct 2008]

GeneCards Summary for HTRA4 Gene

HTRA4 (HtrA Serine Peptidase 4) is a Protein Coding gene. Diseases associated with HTRA4 include pre-eclampsia. GO annotations related to this gene include serine-type endopeptidase activity and insulin-like growth factor binding. An important paralog of this gene is HTRA3.

UniProtKB/Swiss-Prot for HTRA4 Gene

  • Serine protease.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTRA4 Gene

Genomics for HTRA4 Gene

Regulatory Elements for HTRA4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HTRA4 Gene

38,974,149 bp from pter
38,988,662 bp from pter
14,514 bases
Plus strand

Genomic View for HTRA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HTRA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTRA4 Gene

Proteins for HTRA4 Gene

  • Protein details for HTRA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine protease HTRA4
    Protein Accession:
    Secondary Accessions:
    • Q542Z4
    • Q6PF13

    Protein attributes for HTRA4 Gene

    476 amino acids
    Molecular mass:
    50979 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HTRA4 Gene

Proteomics data for HTRA4 Gene at MOPED

Selected DME Specific Peptides for HTRA4 Gene

Post-translational modifications for HTRA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HTRA4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for HTRA4 Gene

Suggested Antigen Peptide Sequences for HTRA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P83105
  • Contains 1 IGFBP N-terminal domain.
  • Contains 1 Kazal-like domain.
  • Contains 1 PDZ (DHR) domain.
  • Belongs to the peptidase S1C family.
genes like me logo Genes that share domains with HTRA4: view

No data available for Gene Families for HTRA4 Gene

Function for HTRA4 Gene

Molecular function for HTRA4 Gene

UniProtKB/Swiss-Prot Function:
Serine protease.

Enzyme Numbers (IUBMB) for HTRA4 Gene

Gene Ontology (GO) - Molecular Function for HTRA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004175 endopeptidase activity IDA 18387192
GO:0004252 serine-type endopeptidase activity IEA --
GO:0005515 protein binding --
GO:0005520 insulin-like growth factor binding IEA --
genes like me logo Genes that share ontologies with HTRA4: view

Animal Model Products

miRNA for HTRA4 Gene

miRTarBase miRNAs that target HTRA4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTRA4

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HTRA4 Gene

Localization for HTRA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTRA4 Gene


Subcellular locations from

Jensen Localization Image for HTRA4 Gene COMPARTMENTS Subcellular localization image for HTRA4 gene
Compartment Confidence
extracellular 2
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HTRA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with HTRA4: view

Pathways for HTRA4 Gene

SuperPathways for HTRA4 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HTRA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IEA --
GO:0006508 proteolysis IDA 18387192
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with HTRA4: view

No data available for Pathways by source for HTRA4 Gene

Transcripts for HTRA4 Gene

mRNA/cDNA for HTRA4 Gene

Unigene Clusters for HTRA4 Gene

HtrA serine peptidase 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HTRA4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTRA4 Gene

No ASD Table

Relevant External Links for HTRA4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HTRA4 Gene

mRNA expression in normal human tissues for HTRA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HTRA4 Gene

This gene is overexpressed in Lung (6.7) and Adipose - Subcutaneous (5.4).

Protein differential expression in normal tissues for HTRA4 Gene

This gene is overexpressed in Cervix (53.9) and Placenta (15.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HTRA4 Gene

SOURCE GeneReport for Unigene cluster for HTRA4 Gene Hs.661014

genes like me logo Genes that share expressions with HTRA4: view

Expression partners for HTRA4 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HTRA4 Gene

Orthologs for HTRA4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HTRA4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HTRA4 35
  • 78.57 (n)
  • 69.12 (a)
HTRA4 36
  • 68 (a)
(Canis familiaris)
Mammalia LOC475580 35
  • 80.39 (n)
  • 70.26 (a)
HTRA4 36
  • 71 (a)
(Mus musculus)
Mammalia Htra4 35
  • 76.17 (n)
  • 68.37 (a)
Htra4 16
Htra4 36
  • 66 (a)
(Pan troglodytes)
Mammalia HTRA4 35
  • 99.65 (n)
  • 99.37 (a)
HTRA4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Htra4 35
  • 75.13 (n)
  • 68.6 (a)
(Monodelphis domestica)
Mammalia HTRA4 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
(Anolis carolinensis)
Reptilia HTRA4 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488607 35
  • 61.75 (n)
  • 58.06 (a)
(Danio rerio)
Actinopterygii LOC100334257 35
  • 58.6 (n)
  • 55.3 (a)
htra4 36
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta HtrA2 36
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for HTRA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HTRA4 Gene

Gene Tree for HTRA4 (if available)
Gene Tree for HTRA4 (if available)

Paralogs for HTRA4 Gene

Paralogs for HTRA4 Gene

Selected SIMAP similar genes for HTRA4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HTRA4: view

Variants for HTRA4 Gene

Sequence variations from dbSNP and Humsavar for HTRA4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs4733894 -- 38,985,874(+) AAATG(C/T)GAAAA intron-variant
rs4733959 -- 38,977,827(+) TTCTC(A/G)GGTGG intron-variant
rs4733960 -- 38,977,937(+) TCCCT(C/T)TTTGG intron-variant
rs4733961 -- 38,978,147(+) ATTAA(C/T)GTAAG synonymous-codon, reference
rs4733962 -- 38,982,781(+) GGCTT(C/T)GGGAT intron-variant

Relevant External Links for HTRA4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HTRA4 Gene

Disorders for HTRA4 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for HTRA4 Gene in MalaCards »

(1) Diseases for HTRA4 Gene including...

genes like me logo Genes that share disorders with HTRA4: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for HTRA4 Gene

Publications for HTRA4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3
  4. A pathway sensor for genome-wide screens of intracellular proteolytic cleavage. (PMID: 18387192) Ketteler R. … Seed B. (Genome Biol. 2008) 3
  5. High-temperature requirement protein A4 (HtrA4) suppresses the fusogenic activity of syncytin-1 and promotes trophoblast invasion. (PMID: 22778138) Wang L.J. … Chen H. (Mol. Cell. Biol. 2012) 3

Products for HTRA4 Gene

Sources for HTRA4 Gene

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