Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HTRA4 Gene

protein-coding GIFtS: 46
GCID: GC08P038831

HtrA serine peptidase 4

Explore 9 diseases affiliated with
HTRA4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
HtrA Serine Peptidase 4¹ ²		Serine Protease HTRA4²
High-Temperature Requirement Factor A4² ³		EC 3.4.21.-³
FLJ90724¹		EC 3.4.21⁸
Probable Serine Protease HTRA4²		EC 3.4.21.108⁸

External Ids:	HGNC: 26909¹	Entrez Gene: 203100²	Ensembl: ENSG00000169495⁷	OMIM: 610700⁵	UniProtKB: P83105³

Export aliases for HTRA4 gene to outside databases

Previous GC identifers: GC08P038951 GC08P037364

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HTRA4:

This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an

insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain.

Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease

to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor

suppression, unfolded stress response, apoptosis, and aging. (provided by RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: HTRA4_HUMAN, P83105

Function: Serine protease (Probable)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_167187.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HTRA4 gene promoter:
GR USF1 AML1a GR-beta LUN-1 PPAR-gamma1 S8 USF-1 PPAR-gamma2 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HTRA4 promoter sequence

Search SABiosciences Chromatin IP Primers for HTRA4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTRA4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.22 Ensembl cytogenetic band: 8p11.22 HGNC cytogenetic band: 8p11.23

HTRA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTRA4 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P038831: view genomic region (about GC identifiers)

Start:	38,831,668 bp from pter	End:	38,846,181 bp from pter
Size:	14,514 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HTRA4_HUMAN, P83105 (See protein sequence)

Recommended Name: Serine protease HTRA4 precursor

Size: 476 amino acids; 50979 Da

Subcellular location: Secreted (By similarity)

Secondary accessions: Q542Z4 Q6PF13

Explore the universe of human proteins at neXtProt for HTRA4: NX_P83105

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P83105

2 DME Specific Peptides for HTRA4 (P83105)

GNSGGPL

GFIVSEDG

HTRA4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_710159.1

ENSEMBL proteins:

ENSP00000305919

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: HTRA4 OriGene Custom Protein Services for HTRA4
	GenScript Custom Purified and Recombinant Proteins Services for HTRA4
	Novus Biologicals HTRA4 Protein Novus Biologicals HTRA4 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HTRA4

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

HTRA4 for ontologies About GeneDecksing

HTRA4 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for HTRA4
	GenScript Custom Superior Antibodies Services for HTRA4
	Novus Biologicals HTRA4 Antibodies
	Search for Antibodies for HTRA4 at Abcam
	Uscn Antibodies for HTRA4
	Search ThermoFisher Antibodies for HTRA4

Assay Products for HTRA4:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HTRA4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HTRA4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HTRA4 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR002350 Prot_inh_Kazal

IPR001940 Peptidase_S1C

IPR000867 IGFBP-like

IPR001478 PDZ

IPR009003 Trypsin-like_Pept_dom

Graphical View of Domain Structure for InterPro Entry P83105

ProtoNet protein and cluster: P83105

2 Blocks protein families:

IPB001478 PDZ/DHR/GLGF domain

IPB001940 HtrA/DegQ protease family signature

UniProtKB/Swiss-Prot: HTRA4_HUMAN, P83105

Similarity: Belongs to the peptidase S1B family

Similarity: Contains 1 IGFBP N-terminal domain

Similarity: Contains 1 Kazal-like domain

Similarity: Contains 1 PDZ (DHR) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HTRA4_HUMAN, P83105

Function: Serine protease (Probable)

Enzyme Numbers (IUBMB): EC 3.4.21² EC 3.4.21.108² EC 3.4.21.-¹

miRNA Products:		OriGene 3'-UTR Clone: HTRA4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HTRA4
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate HTRA4:
		hsa-miR-1271 hsa-miR-96
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HTRA4 (see all 7) OriGene shRNA RFP: HTRA4 OriGene siRNA: HTRA4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HTRA4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HTRA4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTRA4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTRA4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HTRA4 (NM_153692)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTRA4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTRA4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HTRA4
		Search LifeMap BioReagents cell lines for HTRA4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTRA4

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004252	serine-type endopeptidase activity	IEA	--
GO:0005515	protein binding	--	--
GO:0005520	insulin-like growth factor binding	IEA	--

HTRA4 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HTRA4

1 Interacting protein for HTRA4 (P83105³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
XIAP	P98170³	I2D: score=1

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001558	regulation of cell growth	IEA	--
GO:0006508	proteolysis	IEA	--
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	ISS	--

HTRA4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HTRA4
Search CenterWatch for drugs/clinical trials and news about HTRA4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HTRA4 gene:

NM_153692.3

Unigene Cluster for HTRA4:

HtrA serine peptidase 4

Hs.661014 [show with all ESTs]

Unigene Representative Sequence: NM_153692

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000302495(uc003xmj.3)

miRNA Products:		OriGene 3'-UTR Clone: HTRA4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HTRA4
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate HTRA4:
		hsa-miR-1271 hsa-miR-96
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HTRA4 (see all 7) OriGene shRNA RFP: HTRA4 OriGene siRNA: HTRA4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HTRA4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTRA4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTRA4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HTRA4 (NM_153692)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTRA4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTRA4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HTRA4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HTRA4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HTRA4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTRA4

Additional cDNA sequence:

AK075205.1 AK300197.1 AY188774.1 BC057765.1

3 DOTS entries:

DT.91711356 DT.100749850 DT.100757840

24/30 AceView cDNA sequences (see all 30):

CR601506 CR590249 AL553302 NM_153692 AL545759 BX416892 CB961876 AK075205

BQ011847 CB991519 AL551918 BX380962 BU753896 CB961875 AL551947 BC057765

AL551062 BX451410 AL576444 AY188774 AL574735 BX358760 BF511757 AL545720

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HTRA4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCACACATTT

About this image

HTRA4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Sertoli cells

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HTRA4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HTRA4

SOURCE GeneReport for Unigene cluster: Hs.661014

SABiosciences Expression via Pathway-Focused PCR Arrays including HTRA4:

Unfolded Protein Response in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HTRA4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HTRA4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HTRA4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTRA4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTRA4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for HTRA4 gene from 6/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	HTRA4⁶	--	60(a)	1 ↔ 1	GL343418.1(535130-540485)
zebrafish (Danio rerio)	Actinopterygii	LOC100334257¹	serine protease HTRA1-like	58.64(n) 55.56(a)		100334257 XM_002662005.2 XP_002662051.2
fruit fly (Drosophila melanogaster)	Insecta	HtrA2⁶	HtrA2	36(a)	1 → many	3R(10334771-10337434)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G27660⁶ AT5G54745⁶ (see all 14)	putative Do-like 15 protein (see all 14)	28(a) 22(a) (see all 14)	1 ↔ many possible ortholog (see all 14)	5(9789468-9792299) 5(22240256-22241233)
rice (Oryza sativa)	Liliopsida	-- -- (see all 8)	OsDegp12 - Putative Deg protease homologue, expres... OsDegp15 - Putative Deg protease homologue, expres... (see all 8)	23(a) 22(a) (see all 8)	1 ↔ many possible ortholog (see all 8)	11(7904958-7912868) 12(26146553-26151383)
E. coli (Escherichia coli)	Gamma proteobacteria	degS⁶ degP⁶ (see all 3)	serine endoprotease, periplasmic serine endoprotease (protease Do), membrane-associ... (see all 3)	24(a) 20(a) (see all 3)	possible ortholog possible ortholog (see all 3)	Chromosome(3380222-3381289) Chromosome(180884-182308)

ENSEMBL Gene Tree for HTRA4 (if available)
TreeFam Gene Tree for HTRA4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HTRA4 gene

HTRA1² HTRA2² HTRA3²

3 SIMAP similar genes for HTRA4 using alignment to 1 protein entry: HTRA4_HUMAN:

HTRA1 HTRA3 HTRA2

HTRA4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs148320690^1,2	C,	--	38832210(+)	`GGTCCC/GGGCCG`	2	P R	mis¹		0	--	--	--	--
rs114482381^1,2	C,F,	--	38832547(+)	`TTTCAT/CAGGGA`	1	--	int¹		1		WA	118
rs144266191^1,2	C,F,	--	38832564(+)	`GCGCAG/AGCCCG`	2	/S /G	mis¹		1		NA	4552
rs146242051^1,2	C,	--	38832607(+)	`GGTGGA/TGAAGG`	2	E V	mis¹		0	--	--	--	--
rs116529031^1,2	C,F,	--	38832610(+)	`GGAGAA/TGGTGG`	2	K M	mis¹		1		NA	4552
rs76510216^1,2	C,	--	38832628(+)	`GGTGGG/TTCACG`	2	G V	mis¹		0	--	--	--	--
rs141254036^1,2	C,F,	--	38832634(+)	`TCACGT/CGCAGC`	2	/A /V	mis¹		1		NA	4552
rs201976344^1,2		--	38832683(+)	`GTCCCA/CGCTAA`	1	--	int¹		0	--	--	--	--
rs201547387^1,2		--	38832741(+)	`ATCCT-/AAAAAA`	1	--	int¹		0	--	--	--	--
rs138161345^1,2		--	38832775(+)	`AAGAGA/GTTGAA`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HTRA4 (38831668 - 38846181 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HTRA4: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HTRA4

DNA2.0 Custom Variant and Variant Library Synthesis for HTRA4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HTRA4 for disorders           About GeneDecksing

OMIM gene information: 610700    OMIM disorders: --

9 diseases for HTRA4:    About MalaCards

severe pre-eclampsia pre-eclampsia arthritis leprosy

eclampsia pneumonia tuberculosis malaria

mycobacterium tuberculosis

Export disorders for HTRA4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HTRA4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HTRA4)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
High-temperature requirement protein A4 (HtrA4) suppre sses the fusogenic activity of syncytin-1 and promotes trophoblast invasion. (PubMed id 22778138)¹ Wang L.J....Chen H. (2012)
DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)² Nusbaum C....Lander E.S. (2006)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)¹ Otsuki T....Isogai T. (2005)
The HtrA family of proteases: implications for protein composition and cell fate. (PubMed id 12408815)¹ Clausen T....Ehrmann M. (2002)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Pattern of expression of HtrA1 during mouse development. (PubMed id 15557215)⁹ De Luca A....Baldi A. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 203100	HGNC: 26909	AceView: FLJ90724	Ensembl:ENSG00000169495	euGenes: HUgn203100
ECgene: HTRA4	H-InvDB: HTRA4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HTRA4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HTRA4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for HTRA4 gene:
Search GeneIP for patents involving HTRA4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for HTRA4
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HTRA4		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HTRA4
	OriGene Protein Over-expression Lysate for HTRA4		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for HTRA4		OriGene 3'-UTR Clone for HTRA4
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTRA4		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTRA4
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for HTRA4		OriGene Custom Protein Services for HTRA4
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HTRA4
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HTRA4
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTRA4
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HTRA4
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTRA4
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HTRA4

	GenScript Custom Purified and Recombinant Proteins Services for HTRA4		GenScript cDNA clones with any tag delivered in your preferred vector for HTRA4
	GenScript Custom Assay Services for HTRA4		GenScript Custom Superior Antibodies Services for HTRA4
	GenScript Custom overexpressing Cell Line Services for HTRA4		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in HTRA4 promoter
	Search Chromatin IP Primers for HTRA4
	RT² qPCR Primer Assay in human, mouse, rat HTRA4
	Search GNC Networks for HTRA4
	SABiosciences PCR Arrays including human, mouse, rat HTRA4

Search Tocris compounds for HTRA4

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	HTRA4 antibodies
	HTRA4 proteins
	HTRA4 lysates

	Search for Antibodies for HTRA4 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for HTRA4
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

HTRA4 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for HTRA4

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTRA4

	Browse SwitchGear 3'UTR luciferase reporter plasmids for HTRA4
	SwitchGear Promoter luciferase reporter plasmids for HTRA4

Search ThermoFisher Antibodies for HTRA4

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTRA4

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes HTRA4 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

HTRA4 Gene

HtrA serine peptidase 4

Aliases
for HTRA4 gene

Summaries
for HTRA4 gene

Genomic Views
for HTRA4 gene

Proteins
for HTRA4 gene

Protein Domains /
Families
for HTRA4 gene

Function
for HTRA4 gene

Pathways & Interactions
for HTRA4 gene

Drugs & Compounds
for HTRA4 gene

Transcripts
for HTRA4 gene

Expression
for HTRA4 gene

Orthologs
for HTRA4 gene

Paralogs
for HTRA4 gene

Genomic Variants
for HTRA4 gene

Disorders / Diseases
for HTRA4 gene

Publications
for HTRA4 gene

External Searches for HTRA4 gene

Genome Databases showing HTRA4 gene

Other Databases showing HTRA4 gene

Specialized Databases showing HTRA4 gene

Intellectual Property
for HTRA4 gene

Products
for HTRA4 gene

View Random Gene

Advanced Search

Export list of displayed genes

HTRA4 Gene

HtrA serine peptidase 4

Aliasesfor HTRA4 gene

Summariesfor HTRA4 gene

Genomic Viewsfor HTRA4 gene

Proteinsfor HTRA4 gene

Protein Domains /Familiesfor HTRA4 gene

Functionfor HTRA4 gene

Pathways & Interactionsfor HTRA4 gene

Drugs & Compoundsfor HTRA4 gene

Transcriptsfor HTRA4 gene

Expression for HTRA4 gene

Orthologsfor HTRA4 gene

Paralogsfor HTRA4 gene

Genomic Variantsfor HTRA4 gene

Disorders / Diseasesfor HTRA4 gene

Publicationsfor HTRA4 gene

External Searches for HTRA4 gene

Genome Databases showing HTRA4 gene

Other Databases showing HTRA4 gene

Specialized Databases showing HTRA4 gene

Intellectual Propertyfor HTRA4 gene

Productsfor HTRA4 gene

View Random Gene

Aliases
for HTRA4 gene

Summaries
for HTRA4 gene

Genomic Views
for HTRA4 gene

Proteins
for HTRA4 gene

Protein Domains /
Families
for HTRA4 gene

Function
for HTRA4 gene

Pathways & Interactions
for HTRA4 gene

Drugs & Compounds
for HTRA4 gene

Transcripts
for HTRA4 gene

Expression
for HTRA4 gene

Orthologs
for HTRA4 gene

Paralogs
for HTRA4 gene

Genomic Variants
for HTRA4 gene

Disorders / Diseases
for HTRA4 gene

Publications
for HTRA4 gene

Intellectual Property
for HTRA4 gene

Products
for HTRA4 gene