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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HTRA3 Gene

protein-coding   GIFtS: 52
GCID: GC04P008271

HtrA serine peptidase 3
 Explore 14 diseases affiliated with
HTRA3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HTRA3    

Aliases
for HTRA3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
HtrA Serine Peptidase 31 2     Probable Serine Protease HTRA32
Prsp1 2     Serine Protease HTRA32
Tasp1 2     EC 3.4.21.-3
High-Temperature Requirement Factor A32 3     EC 3.4.218
Pregnancy-Related Serine Protease2 3     EC 3.4.21.1088
PRSP3 5     

External Ids:    HGNC: 304061   Entrez Gene: 940312   Ensembl: ENSG000001708017   OMIM: 6087855   UniProtKB: P831103   

Export aliases for HTRA3 gene to outside databases

Previous GC identifers: GC04P008238 GC04P008421 GC04P008464 GC04P008389 GC04P008191


Summaries
for HTRA3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: HTRA3_HUMAN, P83110
Function: Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans
such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins
possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor.
Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the
development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and
luteinization




Genomic Views
for HTRA3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006051.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HTRA3 gene promoter:
         GR   AhR   ATF-2   GR-beta   Bach2   GR-alpha   c-Jun   Zic3   NF-kappaB1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HTRA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for HTRA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HTRA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16.1

HTRA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTRA3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P008271:  view genomic region     (about GC identifiers)

Start:
 8,271,492 bp from pter      End:
 8,308,838 bp from pter
Size:
 37,347 bases      Orientation:
 plus strand

Proteins
for HTRA3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HTRA3_HUMAN, P83110 (See protein sequence)
Recommended Name: Serine protease HTRA3 precursor  
Size: 453 amino acids; 48608 Da
Subunit: Homotrimer (By similarity). Interacts with TGFB1; the interaction inhibits TGFB-mediated signaling. Interacts
with BMP4; the interaction inhibits BMP4-mediated signaling. Interacts with TGFB2 and GDF5 (By similarity). Interacts
with MYH9
Subcellular location: Secreted. Note=Secretion increased during decidualization of endometrial stromal cells
1 PDB 3D structure from and Proteopedia for HTRA3:
2P3W (3D)    
Secondary accessions: Q7Z7A2
Alternative splicing: 2 isoforms:  P83110-1   P83110-2   

Explore the universe of human proteins at neXtProt for HTRA3: NX_P83110

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P83110

    • 4 DME Specific Peptides for HTRA3 (P83110)
     GNSGGPL  GEVIGINT  NFIADVVEK  GSPFALQNT 

    HTRA3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_444272.1  
    ENSEMBL proteins: 
     ENSP00000303766   ENSP00000371952  

    Human Recombinant Protein Products: 
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    Novus Biologicals HTRA3 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HTRA3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--


    HTRA3 for ontologies           About GeneDecksing



    HTRA3 Antibody Products: 
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    ThermoFisher Antibody for HTRA3

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    Uscn ELISAs and CLIAs for HTRA3

    Protein Domains /
    Families
    for HTRA3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HTRA3 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR002350 Prot_inh_Kazal
     IPR001940 Peptidase_S1C
     IPR000867 IGFBP-like
     IPR001478 PDZ
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry P83110

    ProtoNet protein and cluster: P83110

    3 Blocks protein families:
    IPB001478 PDZ/DHR/GLGF domain
    IPB001940 HtrA/DegQ protease family signature
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: HTRA3_HUMAN, P83110
    Similarity: Belongs to the peptidase S1B family
    Similarity: Contains 1 IGFBP N-terminal domain
    Similarity: Contains 1 Kazal-like domain
    Similarity: Contains 1 PDZ (DHR) domain


    Function
    for HTRA3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HTRA3_HUMAN, P83110
    Function: Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans
    such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins
    possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor.
    Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the
    development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and
    luteinization
    Induction: Down-regulated in ovarian and endometrial cancers (EC). Decrease of 3.2-fold in endometrial cancer

    Enzyme Numbers (IUBMB): EC 3.4.212 EC 3.4.21.1082 EC 3.4.21.-1

    miRNA
    Products:            		 OriGene 3'-UTR Clone: HTRA3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HTRA3
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate HTRA3 (see all 17):
    hsa-miR-30c hsa-miR-30d hsa-miR-30a hsa-miR-144 hsa-miR-24 hsa-miR-1910 hsa-miR-4264 hsa-miR-3120-3p
    SwitchGear 3'UTR luciferase reporter plasmid: HTRA3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HTRA3 (see all 4)
    OriGene shRNA RFP: HTRA3
    OriGene siRNA: HTRA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HTRA3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HTRA3

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HTRA3 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: HTRA3 (NM_053044)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTRA3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HTRA3
    LifeMap BioReagents: cell line associated with HTRA3: PureStem Progenitor E68

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTRA3

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0005515protein binding IPI--
    GO:0005520insulin-like growth factor binding IEA--
    GO:0008236serine-type peptidase activity IDA--


    HTRA3 for ontologies           About GeneDecksing



    Pathways & Interactions
    for HTRA3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HTRA3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for HTRA3 (ENSP000003037664) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC4ENSP000002646064STRING: ENSP00000264606
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0006508proteolysis IDA--
    GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway ISS--
    GO:0030514negative regulation of BMP signaling pathway ISS--


    HTRA3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HTRA3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HTRA3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HTRA3
    1 Novoseek chemical compound relationship for HTRA3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 61.4 8 12513693 (2), 20068077 (1), 12862487 (1), 18559118 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about HTRA3 

    Transcripts
    for HTRA3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HTRA3 gene: 
    NM_053044.3  

    Unigene Cluster for HTRA3:

    HtrA serine peptidase 3
    Hs.479119  [show with all ESTs]
    Unigene Representative Sequence: NM_053044
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307358(uc003gla.3) ENST00000382512(uc003gkz.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: HTRA3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HTRA3
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate HTRA3 (see all 17):
    hsa-miR-30c hsa-miR-30d hsa-miR-30a hsa-miR-144 hsa-miR-24 hsa-miR-1910 hsa-miR-4264 hsa-miR-3120-3p
    SwitchGear 3'UTR luciferase reporter plasmid: HTRA3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HTRA3 (see all 4)
    OriGene shRNA RFP: HTRA3
    OriGene siRNA: HTRA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HTRA3
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HTRA3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HTRA3 (NM_053044)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTRA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTRA3 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HTRA3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HTRA3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HTRA3

    Additional cDNA sequence: 

    AF085878.1 AY040094.2 AY280665.1 AY280666.1 BC034390.1 BC035717.1 

    3 DOTS entries:

    DT.113517  DT.210802  DT.100751933 

    24/116 AceView cDNA sequences (see all 116):

    AI636404 BQ675502 AF085878 BQ183499 AA661652 AI282057 AA496217 AI075340 
    AI348269 BE047790 AI338134 AY280666 BQ004480 BQ880316 BQ574328 AA722547 
    AY280665 AI338572 AA055135 AW130260 BC035717 BM479687 AW338524 CR604057 

    GeneLoc Exon Structure


    Expression
    for HTRA3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HTRA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAGGCTGCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HTRA3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleHyoid Arch MusclesMyoblastsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMyoblastsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Intervertebral disc (IVD) annulus fibrosus (AF) cells (Differentiation of s...)Cartilage

    See HTRA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HTRA3

    SOURCE GeneReport for Unigene cluster: Hs.479119

    UniProtKB/Swiss-Prot: HTRA3_HUMAN, P83110
    Tissue specificity: Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and
    bladder. In the endometrium, expressed in epithelial glands and the stroma. Also present in leukocytes. Isoform 1 is
    predominant in heart and skeletal muscle, whereas isoform 2 is predominant in placenta and kidney

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTRA3

    Orthologs
    for HTRA3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for HTRA3 gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HTRA31 HtrA serine peptidase 3 72.67(n)
    80.22(a)    		   422868  XM_003641256.1  XP_003641304.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HTRA36
    		 --
    		 76(a)
    		 1 ↔ 1
    		 GL343236.1(1594508-1635072)
    zebrafish
    (Danio rerio)    		 Actinopterygii htra3a1 HtrA serine peptidase 3a 67.21(n)
    70.4(a)    		   445108  NM_001003502.1  NP_001003502.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG84643 serine-type peptidase 44(a)   88C3   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G276606
    HHOA6
    (see all 14)    		 protease Do-like 5
    (see all 14)    		 29(a)
    23(a)
    (see all 14)    		 1 ↔ many
    possible ortholog
    (see all 14)    		 5(9789468-9792299)
    4(10149129-10151218)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 8)    		 OsDegp15 - Putative Deg protease homologue, expres...
    OsDegp12 - Putative Deg protease homologue, expres...
    (see all 8)    		 24(a)
    23(a)
    (see all 8)    		 possible ortholog
    1 ↔ many
    (see all 8)    		 12(26146553-26151383)
    11(7904958-7912868)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria degS6
    degQ6
    (see all 3)    		 serine endoprotease, periplasmic
    (see all 3)    		 26(a)
    22(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 Chromosome(3380222-3381289)
    Chromosome(3378765-3380132)


    ENSEMBL Gene Tree for HTRA3 (if available)
    TreeFam Gene Tree for HTRA3 (if available) 

    Paralogs
    for HTRA3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HTRA3 gene
    HTRA12  HTRA22  HTRA42  
    3 SIMAP similar genes for HTRA3 using alignment to 1 protein entry:     HTRA3_HUMAN:
    HTRA1    HTRA4    HTRA2

    HTRA3 for paralogs           About GeneDecksing



    Genomic Variants
    for HTRA3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for HTRA3
         1 CNV: 4375
         3 Indels: 98622 46701 68664
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HTRA3
    DNA2.0 Custom Variant and Variant Library Synthesis for HTRA3

    Disorders / Diseases
    for HTRA3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HTRA3 for disorders           About GeneDecksing

    OMIM gene information: 608785    OMIM disorders: --

    14 diseases for HTRA3:    About MalaCards
    clear cell renal cell carcinoma    otitis media    renal cell carcinoma    meningitis
    bronchitis    tonsillitis    endometrial cancer    pneumonia
    ovarian cancer    lung cancer    carcinoma    tuberculosis
    malaria    mycobacterium tuberculosis

    5 diseases from the University of Copenhagen DISEASES database for HTRA3:
    Otitis media     Pneumonia     Meningitis     Sinusitis
    Bronchitis
    Human Genome Epidemiology (HuGE) Navigator: HTRA3 (9 documents)

    Export disorders for HTRA3 gene to outside databases

    Publications
    for HTRA3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HTRA3 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with HTRA3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2. (PubMed id 12513693)1, 2, 3, 9 Nie G.-Y.... Salamonsen L.A. (2003)
    2. Expression of human HtrA1, HtrA2, HtrA3 and TGF-beta1 genes in primary endometrial cancer. (PubMed id 19424634)1, 2, 9 Narkiewicz J....Lipinska B. (2009)
    3. Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer. (PubMed id 16650464)1, 2, 9 Bowden M.A....Nie G. (2006)
    4. Decidual HtrA3 negatively regulates trophoblast invas ion during human placentation. (PubMed id 21321049)1, 2 Singh H....Nie G. (2011)
    5. Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3. (PubMed id 17962403)1, 2 Runyon S.T....Sidhu S.S. (2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Distribution of the serine protease HtrA1 in normal human tissues. (PubMed id 14500695)1, 3 De Luca A....Baldi A. (2003)
    8. HtrA3 is regulated by 15-deoxy-Delta12,14-prostagland in J2 independently of PPARgamma in clear cell renal cell carcinomas. (PubMed id 19951697)1, 9 ThAcoleyre S....Denis M.G. (2010)
    9. Methylation induced gene silencing of HtrA3 in smokin g-related lung cancer. (PubMed id 20068077)1, 9 Beleford D....Shridhar V. (2010)
    10. Application of the wheat-germ cell-free translation system to produce high temperature requirement A3 (HtrA3) proteases. (PubMed id 22229724)2 Singh H.... Nie G. (2012)

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    Genome Databases showing HTRA3 gene

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    Entrez Gene: 94031 HGNC: 30406 AceView: HTRA3 Ensembl:ENSG00000170801 euGenes: HUgn94031
    ECgene: HTRA3 H-InvDB: HTRA3

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    Specialized Databases showing HTRA3 gene

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