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Aliases for HTRA3 Gene

Aliases for HTRA3 Gene

  • HtrA Serine Peptidase 3 2 3 5
  • Pregnancy-Related Serine Protease 2 3 4
  • High-Temperature Requirement Factor A3 3 4
  • Prsp 3 4
  • Probable Serine Protease HTRA3 3
  • EC 3.4.21.108 63
  • EC 3.4.21.- 4
  • EC 3.4.21 63
  • Tasp 3

External Ids for HTRA3 Gene

Previous GeneCards Identifiers for HTRA3 Gene

  • GC04P008238
  • GC04P008421
  • GC04P008464
  • GC04P008389
  • GC04P008271
  • GC04P008191

Summaries for HTRA3 Gene

GeneCards Summary for HTRA3 Gene

HTRA3 (HtrA Serine Peptidase 3) is a Protein Coding gene. Diseases associated with HTRA3 include Vitreoretinopathy, Neovascular Inflammatory and Purulent Acute Otitis Media. GO annotations related to this gene include serine-type endopeptidase activity and endopeptidase activity. An important paralog of this gene is HTRA2.

UniProtKB/Swiss-Prot for HTRA3 Gene

  • Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (PubMed:21321049, PubMed:22229724).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTRA3 Gene

Genomics for HTRA3 Gene

Regulatory Elements for HTRA3 Gene

Enhancers for HTRA3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HTRA3 on UCSC Golden Path with GeneCards custom track

Promoters for HTRA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HTRA3 on UCSC Golden Path with GeneCards custom track

Genomic Location for HTRA3 Gene

Chromosome:
4
Start:
8,269,754 bp from pter
End:
8,307,111 bp from pter
Size:
37,358 bases
Orientation:
Plus strand

Genomic View for HTRA3 Gene

Genes around HTRA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTRA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTRA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTRA3 Gene

Proteins for HTRA3 Gene

  • Protein details for HTRA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P83110-HTRA3_HUMAN
    Recommended name:
    Serine protease HTRA3
    Protein Accession:
    P83110
    Secondary Accessions:
    • Q7Z7A2

    Protein attributes for HTRA3 Gene

    Size:
    453 amino acids
    Molecular mass:
    48608 Da
    Quaternary structure:
    • Homotrimer (PubMed:26110759). Interacts with TGFB1; the interaction inhibits TGFB-mediated signaling. Interacts with BMP4; the interaction inhibits BMP4-mediated signaling. Interacts with TGFB2 and GDF5 (By similarity). Interacts with MYH9.

    Three dimensional structures from OCA and Proteopedia for HTRA3 Gene

    Alternative splice isoforms for HTRA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HTRA3 Gene

Proteomics data for HTRA3 Gene at MOPED

Selected DME Specific Peptides for HTRA3 Gene

Post-translational modifications for HTRA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HTRA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for HTRA3 Gene

Gene Families for HTRA3 Gene

Suggested Antigen Peptide Sequences for HTRA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P83110

UniProtKB/Swiss-Prot:

HTRA3_HUMAN :
  • Contains 1 IGFBP N-terminal domain.
  • Belongs to the peptidase S1C family.
Domain:
  • Contains 1 IGFBP N-terminal domain.
  • Contains 1 Kazal-like domain.
  • Contains 1 PDZ (DHR) domain.
Family:
  • Belongs to the peptidase S1C family.
genes like me logo Genes that share domains with HTRA3: view

Function for HTRA3 Gene

Molecular function for HTRA3 Gene

UniProtKB/Swiss-Prot Function:
Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (PubMed:21321049, PubMed:22229724).
UniProtKB/Swiss-Prot Induction:
Down-regulated in ovarian and endometrial cancers (EC). Decrease of 3.2-fold in endometrial cancer.

Enzyme Numbers (IUBMB) for HTRA3 Gene

Gene Ontology (GO) - Molecular Function for HTRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IDA 18387192
GO:0008236 serine-type peptidase activity IDA 22229724
genes like me logo Genes that share ontologies with HTRA3: view
genes like me logo Genes that share phenotypes with HTRA3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for HTRA3

miRNA for HTRA3 Gene

miRTarBase miRNAs that target HTRA3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HTRA3 Gene

Localization for HTRA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTRA3 Gene

Secreted. Note=Secretion increased during decidualization of endometrial stromal cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTRA3 Gene COMPARTMENTS Subcellular localization image for HTRA3 gene
Compartment Confidence
extracellular 4
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for HTRA3 Gene

Pathways & Interactions for HTRA3 Gene

SuperPathways for HTRA3 Gene

No Data Available

Interacting Proteins for HTRA3 Gene

Gene Ontology (GO) - Biological Process for HTRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 18387192
GO:0030514 negative regulation of BMP signaling pathway ISS --
genes like me logo Genes that share ontologies with HTRA3: view

No data available for Pathways by source and SIGNOR curated interactions for HTRA3 Gene

Drugs & Compounds for HTRA3 Gene

(1) Drugs for HTRA3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HTRA3: view

Transcripts for HTRA3 Gene

mRNA/cDNA for HTRA3 Gene

Unigene Clusters for HTRA3 Gene

HtrA serine peptidase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HTRA3 Gene

No ASD Table

Relevant External Links for HTRA3 Gene

GeneLoc Exon Structure for
HTRA3
ECgene alternative splicing isoforms for
HTRA3

Expression for HTRA3 Gene

mRNA expression in normal human tissues for HTRA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HTRA3 Gene

This gene is overexpressed in Heart - Atrial Appendage (x7.8).

Protein differential expression in normal tissues from HIPED for HTRA3 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (32.5), Heart (25.8), and Peripheral blood mononuclear cells (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HTRA3 Gene



SOURCE GeneReport for Unigene cluster for HTRA3 Gene Hs.479119

mRNA Expression by UniProt/SwissProt for HTRA3 Gene

P83110-HTRA3_HUMAN
Tissue specificity: Widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. In the endometrium, expressed in epithelial glands and the stroma. Also present in leukocytes. Isoform 1 is predominant in heart and skeletal muscle, whereas isoform 2 is predominant in placenta and kidney.
genes like me logo Genes that share expression patterns with HTRA3: view

Protein tissue co-expression partners for HTRA3 Gene

Primer Products

Orthologs for HTRA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HTRA3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HTRA3 35
  • 82.66 (n)
  • 83.59 (a)
HTRA3 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HTRA3 35
  • 88.83 (n)
  • 91.49 (a)
HTRA3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Htra3 35
  • 87.66 (n)
  • 92.87 (a)
Htra3 16
Htra3 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HTRA3 35
  • 97.87 (n)
  • 96.66 (a)
HTRA3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Htra3 35
  • 86.36 (n)
  • 92.64 (a)
oppossum
(Monodelphis domestica)
Mammalia HTRA3 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HTRA3 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves HTRA3 35
  • 73.63 (n)
  • 81.67 (a)
HTRA3 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HTRA3 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia htra3 35
  • 73.04 (n)
  • 79.49 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC573378 35
  • 69.06 (n)
  • 70.26 (a)
HTRA3 (1 of 3) 36
  • 66 (a)
OneToMany
HTRA3 (3 of 3) 36
  • 64 (a)
OneToMany
htra3a 36
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8464 37
  • 44 (a)
HtrA2 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToMany
Species with no ortholog for HTRA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HTRA3 Gene

ENSEMBL:
Gene Tree for HTRA3 (if available)
TreeFam:
Gene Tree for HTRA3 (if available)

Paralogs for HTRA3 Gene

Paralogs for HTRA3 Gene

(3) SIMAP similar genes for HTRA3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HTRA3: view

Variants for HTRA3 Gene

Sequence variations from dbSNP and Humsavar for HTRA3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs15987 -- 8,306,668(-) CCCCC(C/G)CACCC utr-variant-3-prime
rs1130052 -- 8,306,911(+) CGCAG(C/T)TCTGG utr-variant-3-prime
rs1130053 -- 8,306,913(+) CAGCT(C/T)TGGGA utr-variant-3-prime
rs1130065 -- 8,306,951(+) GCCCA(A/G)AGGCA utr-variant-3-prime
rs1130071 -- 8,306,972(+) TGGGC(A/C)CCACC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HTRA3 Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER Inversion 12058347
nsv461216 CNV Loss 19166990
dgv5454n71 CNV Loss 21882294
dgv5455n71 CNV Loss 21882294
nsv829853 CNV Gain+Loss 17160897
dgv5457n71 CNV Loss 21882294
nsv461218 CNV Loss 19166990
esv29195 CNV Loss 19812545
nsv878603 CNV Gain 21882294
nsv4222 CNV Insertion 18451855
esv2493897 CNV Insertion 19546169
esv1430054 CNV Insertion 17803354
esv1923424 CNV Deletion 18987734
esv2727109 CNV Deletion 23290073

Variation tolerance for HTRA3 Gene

Residual Variation Intolerance Score: 34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.11% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HTRA3 Gene

Disorders for HTRA3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for HTRA3 Gene - From: OMIM and DISEASES

Disorder Aliases PubMed IDs
vitreoretinopathy, neovascular inflammatory
  • proliferative vitreoretinopathy
purulent acute otitis media
  • acute suppurative otitis media
middle ear disease
  • disorder of middle ear
streptococcal meningitis
- elite association - COSMIC cancer census association via MalaCards
Search HTRA3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HTRA3

Genetic Association Database (GAD)
HTRA3
Human Genome Epidemiology (HuGE) Navigator
HTRA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTRA3
genes like me logo Genes that share disorders with HTRA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HTRA3 Gene

Publications for HTRA3 Gene

  1. Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2. (PMID: 12513693) Nie G.-Y. … Salamonsen L.A. (Biochem. J. 2003) 2 3 4 23 67
  2. HtrA3 is regulated by 15-deoxy-Delta12,14-prostaglandin J2 independently of PPARgamma in clear cell renal cell carcinomas. (PMID: 19951697) ThAcoleyre S. … Denis M.G. (Biochem. Biophys. Res. Commun. 2010) 3 23
  3. Methylation induced gene silencing of HtrA3 in smoking-related lung cancer. (PMID: 20068077) Beleford D. … Shridhar V. (Clin. Cancer Res. 2010) 3 23
  4. Expression of human HtrA1, HtrA2, HtrA3 and TGF-beta1 genes in primary endometrial cancer. (PMID: 19424634) Narkiewicz J. … Lipinska B. (Oncol. Rep. 2009) 3 23
  5. Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer. (PMID: 16650464) Bowden M.A. … Nie G. (Gynecol. Oncol. 2006) 3 23

Products for HTRA3 Gene

Sources for HTRA3 Gene

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