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Aliases for HTRA2 Gene

Aliases for HTRA2 Gene

  • HtrA Serine Peptidase 2 2 3 5
  • High Temperature Requirement Protein A2 3 4
  • Omi Stress-Regulated Endoprotease 3 4
  • Serine Proteinase OMI 3 4
  • Protease, Serine, 25 2 3
  • Serine Protease 25 3 4
  • EC 3.4.21.108 4 61
  • PRSS25 3 4
  • OMI 3 4
  • Serine Protease HTRA2, Mitochondrial 3
  • HtrA-Like Serine Protease 3
  • PARK13 3
  • MGCA8 3
  • HtrA2 4

External Ids for HTRA2 Gene

Previous HGNC Symbols for HTRA2 Gene

  • PRSS25

Previous GeneCards Identifiers for HTRA2 Gene

  • GC02P074669
  • GC02P074610
  • GC02P074757
  • GC02P074492

Summaries for HTRA2 Gene

Entrez Gene Summary for HTRA2 Gene

  • This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

GeneCards Summary for HTRA2 Gene

HTRA2 (HtrA Serine Peptidase 2) is a Protein Coding gene. Diseases associated with HTRA2 include Parkinson Disease 13 and 3-Methylglutaconic Aciduria 8. Among its related pathways are Apoptosis and Autophagy and Parkinsons Disease Pathway. GO annotations related to this gene include serine-type endopeptidase activity and unfolded protein binding. An important paralog of this gene is HTRA3.

UniProtKB/Swiss-Prot for HTRA2 Gene

  • Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.

Gene Wiki entry for HTRA2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTRA2 Gene

Genomics for HTRA2 Gene

Regulatory Elements for HTRA2 Gene

Enhancers for HTRA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G074570 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +43.5 43451 4.3 HDGF PKNOX1 FOXA2 ARID4B SIN3A YY1 ZNF766 CBX5 ZNF207 JUNB DOK1 LBX2-AS1 HTRA2 AUP1 PCGF1 LBX2 TLX2 DQX1 MRPL53 MOGS
GH02G074575 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +47.7 47712 3.4 CTCF PKNOX1 MAX CEBPG ZBTB40 EED SMC3 ETV6 CREM ZNF639 DOK1 LOXL3 HTRA2 AUP1 DQX1 TLX2 PCGF1 LBX2 TTC31 CCDC142
GH02G074566 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +38.5 38451 3.1 ZFP64 EBF1 ZNF697 CBX5 SCRT2 FOS RELB IKZF2 NFE2L2 EZH2 SEMA4F LBX2 BOLA3-AS1 DUSP11 WBP1 AUP1 HTRA2 TLX2 PCGF1 ENSG00000270571
GH02G074583 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.6 +54.6 54576 1.6 PKNOX1 BACH1 ZNF316 CBX5 FOS NFE2 MAFK CREM NFE2L2 MTA2 LOXL3 DOK1 AUP1 HTRA2 TLX2 PCGF1 TTC31 CCDC142 DQX1 LBX2
GH02G074487 1.3 ENCODE dbSUPER 11.8 -39.0 -39039 4.9 FOXA2 PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 LBX2 AUP1 HTRA2 DQX1 MOGS TLX2 WBP1 DOK1 LOXL3 GC02P074500
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HTRA2 on UCSC Golden Path with GeneCards custom track

Promoters for HTRA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000119180 523 2201 CREB3L1 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21

Genomic Location for HTRA2 Gene

Chromosome:
2
Start:
74,529,377 bp from pter
End:
74,533,556 bp from pter
Size:
4,180 bases
Orientation:
Plus strand

Genomic View for HTRA2 Gene

Genes around HTRA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTRA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTRA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTRA2 Gene

Proteins for HTRA2 Gene

  • Protein details for HTRA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43464-HTRA2_HUMAN
    Recommended name:
    Serine protease HTRA2, mitochondrial
    Protein Accession:
    O43464
    Secondary Accessions:
    • Q9HBZ4
    • Q9P0Y3
    • Q9P0Y4

    Protein attributes for HTRA2 Gene

    Size:
    458 amino acids
    Molecular mass:
    48841 Da
    Quaternary structure:
    • Homotrimer. Interacts with MXI2. Interacts with THAP5 under apoptotic conditions. The mature protein, but not the precursor, binds to BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Interacts with BIRC6/bruce.

    Three dimensional structures from OCA and Proteopedia for HTRA2 Gene

    Alternative splice isoforms for HTRA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HTRA2 Gene

Selected DME Specific Peptides for HTRA2 Gene

O43464:
  • GSPFALQNT
  • GNSGGPL
  • NFIADVVEK

Post-translational modifications for HTRA2 Gene

Other Protein References for HTRA2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HTRA2 (HTRA2)

Domains & Families for HTRA2 Gene

Suggested Antigen Peptide Sequences for HTRA2 Gene

Graphical View of Domain Structure for InterPro Entry

O43464

UniProtKB/Swiss-Prot:

HTRA2_HUMAN :
  • The mature N-terminus is involved in the interaction with XIAP.
  • Belongs to the peptidase S1C family.
Domain:
  • The mature N-terminus is involved in the interaction with XIAP.
  • The PDZ domain mediates interaction with MXI2.
Family:
  • Belongs to the peptidase S1C family.
genes like me logo Genes that share domains with HTRA2: view

Function for HTRA2 Gene

Molecular function for HTRA2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues.
UniProtKB/Swiss-Prot Function:
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.

Enzyme Numbers (IUBMB) for HTRA2 Gene

Gene Ontology (GO) - Molecular Function for HTRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA,TAS 10873535
GO:0005515 protein binding IPI 10971580
GO:0008233 peptidase activity IMP 24709290
GO:0008236 serine-type peptidase activity TAS 18309324
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with HTRA2: view
genes like me logo Genes that share phenotypes with HTRA2: view

Animal Models for HTRA2 Gene

MGI Knock Outs for HTRA2:

Animal Model Products

CRISPR Products

miRNA for HTRA2 Gene

miRTarBase miRNAs that target HTRA2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HTRA2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HTRA2 Gene

Localization for HTRA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTRA2 Gene

Mitochondrion intermembrane space. Mitochondrion membrane; Single-pass membrane protein. Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HTRA2 gene
Compartment Confidence
mitochondrion 5
nucleus 5
endoplasmic reticulum 5
cytosol 5
cytoskeleton 4
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for HTRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IDA 24798695
GO:0005634 nucleus IDA 10971580
GO:0005739 mitochondrion TAS 18309324
GO:0005758 mitochondrial intermembrane space IDA 15044455
GO:0005783 endoplasmic reticulum NAS 10995577
genes like me logo Genes that share ontologies with HTRA2: view

Pathways & Interactions for HTRA2 Gene

genes like me logo Genes that share pathways with HTRA2: view

Pathways by source for HTRA2 Gene

1 GeneTex pathway for HTRA2 Gene
1 Cell Signaling Technology pathway for HTRA2 Gene

SIGNOR curated interactions for HTRA2 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for HTRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,TAS 10873535
GO:0006672 ceramide metabolic process IEA --
GO:0006915 apoptotic process IEA --
GO:0007005 mitochondrion organization IEA --
GO:0007568 aging IEA --
genes like me logo Genes that share ontologies with HTRA2: view

Drugs & Compounds for HTRA2 Gene

(1) Drugs for HTRA2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HTRA2: view

Transcripts for HTRA2 Gene

Unigene Clusters for HTRA2 Gene

HtrA serine peptidase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HTRA2

Alternative Splicing Database (ASD) splice patterns (SP) for HTRA2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1: - -
SP2:
SP3:
SP4:
SP5: - - -
SP6:

Relevant External Links for HTRA2 Gene

GeneLoc Exon Structure for
HTRA2
ECgene alternative splicing isoforms for
HTRA2

Expression for HTRA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HTRA2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HTRA2 Gene



Protein tissue co-expression partners for HTRA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HTRA2 Gene:

HTRA2

SOURCE GeneReport for Unigene cluster for HTRA2 Gene:

Hs.744841

mRNA Expression by UniProt/SwissProt for HTRA2 Gene:

O43464-HTRA2_HUMAN
Tissue specificity: Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.

Evidence on tissue expression from TISSUES for HTRA2 Gene

  • Nervous system(4.8)
  • Kidney(4.4)
  • Liver(4.3)
  • Heart(2.3)
  • Muscle(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HTRA2 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • integumentary
  • nervous
  • skeletal muscle
  • urinary
Organs:
Head and neck:
  • brain
  • cerebellum
  • eye
  • eyelid
  • face
  • head
Pelvis:
  • urethra
  • urinary bladder
General:
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
genes like me logo Genes that share expression patterns with HTRA2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for HTRA2 Gene

Orthologs for HTRA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HTRA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTRA2 34 35
  • 99.17 (n)
dog
(Canis familiaris)
Mammalia HTRA2 34 35
  • 90.6 (n)
cow
(Bos Taurus)
Mammalia HTRA2 34 35
  • 89.96 (n)
oppossum
(Monodelphis domestica)
Mammalia HTRA2 35
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Htra2 34
  • 86.17 (n)
mouse
(Mus musculus)
Mammalia Htra2 34 16 35
  • 86.1 (n)
chicken
(Gallus gallus)
Aves HTRA2 34 35
  • 71.05 (n)
lizard
(Anolis carolinensis)
Reptilia HTRA2 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11096 34
zebrafish
(Danio rerio)
Actinopterygii HTRA2 (12 of 31) 35
  • 69 (a)
OneToMany
HTRA2 (16 of 31) 35
  • 69 (a)
OneToMany
HTRA2 (26 of 31) 35
  • 69 (a)
OneToMany
HTRA2 (1 of 31) 35
  • 68 (a)
OneToMany
HTRA2 (13 of 31) 35
  • 68 (a)
OneToMany
HTRA2 (18 of 31) 35
  • 68 (a)
OneToMany
HTRA2 (24 of 31) 35
  • 68 (a)
OneToMany
HTRA2 (28 of 31) 35
  • 68 (a)
OneToMany
HTRA2 (3 of 31) 35
  • 68 (a)
OneToMany
HTRA2 (6 of 31) 35
  • 68 (a)
OneToMany
HTRA2 (7 of 31) 35
  • 68 (a)
OneToMany
HTRA2 (10 of 31) 35
  • 67 (a)
OneToMany
HTRA2 (15 of 31) 35
  • 67 (a)
OneToMany
HTRA2 (31 of 31) 35
  • 67 (a)
OneToMany
HTRA2 (11 of 31) 35
  • 66 (a)
OneToMany
HTRA2 (14 of 31) 35
  • 66 (a)
OneToMany
HTRA2 (17 of 31) 35
  • 66 (a)
OneToMany
HTRA2 (2 of 31) 35
  • 66 (a)
OneToMany
HTRA2 (27 of 31) 35
  • 66 (a)
OneToMany
HTRA2 (5 of 31) 35
  • 66 (a)
OneToMany
LOC100330919 34
  • 65.15 (n)
HTRA2 (23 of 31) 35
  • 65 (a)
OneToMany
HTRA2 (29 of 31) 35
  • 65 (a)
OneToMany
HTRA2 (9 of 31) 35
  • 64 (a)
OneToMany
HTRA2 (8 of 31) 35
  • 63 (a)
OneToMany
HTRA2 (30 of 31) 35
  • 61 (a)
OneToMany
HTRA2 (20 of 31) 35
  • 60 (a)
OneToMany
HTRA2 (25 of 31) 35
  • 60 (a)
OneToMany
HTRA2 (22 of 31) 35
  • 59 (a)
OneToMany
HTRA2 (19 of 31) 35
  • 55 (a)
OneToMany
HTRA2 (21 of 31) 35
  • 52 (a)
OneToMany
HTRA2 (4 of 31) 35
  • 38 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000240 34
  • 59.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta HtrA2 34 35
  • 55.74 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
Species where no ortholog for HTRA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HTRA2 Gene

ENSEMBL:
Gene Tree for HTRA2 (if available)
TreeFam:
Gene Tree for HTRA2 (if available)

Paralogs for HTRA2 Gene

Paralogs for HTRA2 Gene

(3) SIMAP similar genes for HTRA2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HTRA2: view

Variants for HTRA2 Gene

Sequence variations from dbSNP and Humsavar for HTRA2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs767006508 Pathogenic, 3-methylglutaconic aciduria 8 (MGCA8) [MIM:617248] 74,532,714(+) ACACC(A/G)GTGAG intron-variant, nc-transcript-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
VAR_046135 Parkinson disease 13 (PARK13) [MIM:610297]
rs1057519080 Pathogenic 74,532,924(+) GGCAG(-/TGCAG)ATCCG nc-transcript-variant, downstream-variant-500B, reference, utr-variant-3-prime, frameshift-variant
rs1057519081 Pathogenic 74,531,106(+) TTGAT(C/G)TGCGT intron-variant, upstream-variant-2KB, splice-donor-variant
rs114661282 Likely benign 74,533,516(+) TGCTG(A/G)CATGG nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HTRA2 Gene

Variant ID Type Subtype PubMed ID
esv2759061 CNV loss 17122850
nsv458185 CNV loss 19166990
nsv515851 CNV loss 19592680
nsv582214 CNV loss 21841781

Variation tolerance for HTRA2 Gene

Residual Variation Intolerance Score: 31.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTRA2 Gene

Human Gene Mutation Database (HGMD)
HTRA2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HTRA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTRA2 Gene

Disorders for HTRA2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for HTRA2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
parkinson disease 13
  • park13
3-methylglutaconic aciduria 8
  • 3-methylglutaconic aciduria, type vii
htra2-related parkinson disease
  • parkinson disease 13
ophthalmomyiasis
  • ocular myiasis
parkinson disease, juvenile, type 2
  • autosomal recessive juvenile parkinson disease 2
- elite association - COSMIC cancer census association via MalaCards
Search HTRA2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

HTRA2_HUMAN
  • Parkinson disease 13 (PARK13) [MIM:610297]: A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. {ECO:0000269 PubMed:15961413, ECO:0000269 PubMed:18401856}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for HTRA2

Genetic Association Database (GAD)
HTRA2
Human Genome Epidemiology (HuGE) Navigator
HTRA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTRA2
genes like me logo Genes that share disorders with HTRA2: view

No data available for Genatlas for HTRA2 Gene

Publications for HTRA2 Gene

  1. Genetic variability in the mitochondrial serine protease HTRA2 contributes to risk for Parkinson disease. (PMID: 18401856) Bogaerts V. … Van Broeckhoven C. (Hum. Mutat. 2008) 3 4 22 46 64
  2. Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia. (PMID: 10644717) Faccio L. … Zervos A.S. (J. Biol. Chem. 2000) 2 3 4 22 64
  3. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. (PMID: 11583623) Suzuki Y. … Takahashi R. (Mol. Cell 2001) 3 4 22 64
  4. Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response. (PMID: 10971580) Gray C.W. … Creasy C.L. (Eur. J. Biochem. 2000) 2 3 4 64
  5. Tissue-specific splicing of Omi stress-regulated endoprotease leads to an inactive protease with a modified PDZ motif. (PMID: 10995577) Faccio L. … Zervos A.S. (Genomics 2000) 3 4 22 64

Products for HTRA2 Gene

  • Addgene plasmids for HTRA2

Sources for HTRA2 Gene

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