Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HTRA2 Gene

protein-coding   GIFtS: 68
GCID: GC02P074757

HtrA Serine Peptidase 2

(Previous names: protease, serine, 25)
(Previous symbol: PRSS25)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
HtrA Serine Peptidase 21 2     Omi Stress-Regulated Endoprotease2 3
PRSS251 2 3 5     EC 3.4.21.1083 8
OMI2 3 5     PARK132 5
Protease, Serine, 251 2     HtrA-Like Serine Protease2
High Temperature Requirement Protein A22 3     Serine Protease HTRA2, Mitochondrial2
Serine Protease 252 3     HtrA23
Serine Proteinase OMI2 3     

External Ids:    HGNC: 143481   Entrez Gene: 274292   Ensembl: ENSG000001153177   OMIM: 6064415   UniProtKB: O434643   

Export aliases for HTRA2 gene to outside databases

Previous GC identifers: GC02P074669 GC02P074610 GC02P074492


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HTRA2 Gene:
This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts
with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to
the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce
apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization
of this protein has also been observed. Alternate splicing of this gene results in two transcript variants
encoding different isoforms. Additional transcript variants have been described, but their full-length sequences
have not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for HTRA2 Gene:
HTRA2 (HtrA serine peptidase 2) is a protein-coding gene. Diseases associated with HTRA2 include parkinson disease 13, and htra2-related parkinson disease. GO annotations related to this gene include peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is HTRA1.

UniProtKB/Swiss-Prot: HTRA2_HUMAN, O43464
Function: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes
or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of
apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent,
caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation
during apoptosis. Isoform 2 seems to be proteolytically inactive

Gene Wiki entry for HTRA2 (HtrA serine peptidase 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the HTRA2 gene promoter:
         STAT1   AP-1   STAT1beta   Nkx2-5   MIF-1   LCR-F1   Gfi-1   STAT1alpha   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): HTRA2 promoter sequence
   Search Chromatin IP Primers for HTRA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HTRA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p12   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p13.1

HTRA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HTRA2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P074757:  view genomic region     (about GC identifiers)

Start:
74,756,504 bp from pter      End:
74,760,683 bp from pter
Size:
4,180 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HTRA2_HUMAN, O43464 (See protein sequence)
Recommended Name: Serine protease HTRA2, mitochondrial precursor  
Size: 458 amino acids; 48841 Da
Subunit: Homotrimer. Interacts with MXI2. Interacts with THAP5 under apoptotic conditions. The mature protein, but
not the precursor, binds to BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Interacts with BIRC6/bruce
2 PDB 3D structures from and Proteopedia for HTRA2:
1LCY (3D)        2PZD (3D)    
Secondary accessions: Q9HBZ4 Q9P0Y3 Q9P0Y4
Alternative splicing: 4 isoforms:  O43464-1   O43464-2   O43464-3   O43464-4   

Explore the universe of human proteins at neXtProt for HTRA2: NX_O43464

Explore proteomics data for HTRA2 at MOPED

Post-translational modifications: 

  • Autoproteolytically activated1
  • Ubiquitination2 at Lys237, Lys395
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for HTRA2 (O43464)
     GNSGGPL  NFIADVVEK  GSPFALQNT 


    See HTRA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_037379.1  NP_659540.1  

    ENSEMBL proteins: 
     ENSP00000258080   ENSP00000312893   ENSP00000399166  

    HTRA2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for HTRA2 (HTRA2/Omi)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HTRA2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HTRA2
    GenScript Custom Purified and Recombinant Proteins Services for HTRA2
    Novus Biologicals HTRA2 Proteins
    Sino Biological Recombinant Protein for HTRA2
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HTRA2
    Cloud-Clone Corp. Proteins for HTRA2

    HTRA2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for HTRA2 (HTRA2/Omi)
    Cell Signaling Technology (CST) Antibodies for HTRA2 
    OriGene Antibodies for HTRA2
    OriGene Custom Antibody Services for HTRA2
    Novus Biologicals HTRA2 Antibodies
    Abcam antibodies for HTRA2
    Cloud-Clone Corp. Antibodies for HTRA2
    ThermoFisher Antibody for HTRA2
    LSBio Antibodies in human, mouse, rat for HTRA2

    HTRA2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HTRA2
    R&D Systems ELISAs for HTRA2 (HTRA2/Omi)         (see all)
    GenScript Custom Assay Services for HTRA2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HTRA2
    Cloud-Clone Corp. CLIAs for HTRA2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PARK: Parkinson disease
    PRSS: Serine peptidases / Serine peptidases

    4 InterPro protein domains:
     IPR001940 Peptidase_S1C
     IPR001254 Peptidase_S1
     IPR001478 PDZ
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry O43464

    ProtoNet protein and cluster: O43464

    3 Blocks protein domains:
    IPB001254 Serine protease
    IPB001478 PDZ/DHR/GLGF domain
    IPB001940 HtrA/DegQ protease family signature


    UniProtKB/Swiss-Prot: HTRA2_HUMAN, O43464
    Domain: The mature N-terminus is involved in the interaction with XIAP
    Domain: The PDZ domain mediates interaction with MXI2
    Similarity: Belongs to the peptidase S1B family
    Similarity: Contains 1 PDZ (DHR) domain


    HTRA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HTRA2_HUMAN, O43464
    Function: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes
    or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of
    apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent,
    caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation
    during apoptosis. Isoform 2 seems to be proteolytically inactive
    Catalytic activity: Cleavage of non-polar aliphatic amino acids at the P1 position, with a preference for Val, Ile
    and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other
    hydrophilic residues

         Enzyme Number (IUBMB): EC 3.4.21.1081 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity TAS10873535
    GO:0005515protein binding IPI10971580
    GO:0008233peptidase activity IDA11604410
    GO:0008236serine-type peptidase activity TAS18309324
         
    HTRA2 for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Htra2):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  mortality/aging 
     muscle  nervous system 

    HTRA2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Htra2tm1Jdo for HTRA2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HTRA2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HTRA2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HTRA2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HTRA2

    miRNA
    Products:
        
    miRTarBase miRNAs that target HTRA2:
    hsa-mir-744-5p (MIRT037592)

    Block miRNA regulation of human, mouse, rat HTRA2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HTRA2 (see all 24):
    hsa-miR-485-5p hsa-miR-15a hsa-miR-885-5p hsa-miR-410 hsa-miR-27b* hsa-miR-424 hsa-miR-28-5p hsa-miR-3649
    SwitchGear 3'UTR luciferase reporter plasmidHTRA2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HTRA2
    Predesigned siRNA for gene silencing in human, mouse, rat HTRA2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HTRA2

    Clone
    Products:
         
    OriGene clones in human, mouse for HTRA2 (see all 13)
    OriGene ORF clones in mouse, rat for HTRA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HTRA2 (NM_013247)
    Sino Biological Human cDNA Clone for HTRA2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTRA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTRA2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HTRA2
    Browse ESI BIO Cell Lines and PureStem Progenitors for HTRA2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTRA2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    HTRA2_HUMAN, O43464: Mitochondrion intermembrane space. Mitochondrion membrane; Single-pass membrane protein
    (Potential). Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic
    stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endoplasmic reticulum5
    mitochondrion5
    nucleus5
    plasma membrane3
    cytoskeleton1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10971580
    GO:0005739mitochondrion TAS18309324
    GO:0005758mitochondrial intermembrane space IDA15044455
    GO:0005783endoplasmic reticulum NAS10995577
    GO:0005789endoplasmic reticulum membrane TAS10644717

    HTRA2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HTRA2 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Parkinson's disease0.57
    2TWEAK Pathway
    Apoptosis and survival TNFR1 signaling pathway0.52
    3Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades0.44
    4Apoptosis (WikiPathways)
    Apoptosis Modulation and Signaling0.38
    5Apoptosis Signaling Pathways
    Apoptosis Signaling Pathways0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for HTRA2
        Apoptosis Signaling Pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HTRA2
        Apoptosis through Death Receptors
    Apoptotic Pathways Triggered By HIV1
    Mitochondrial Apoptosis
    Cellular Apoptosis Pathway

    2 Cell Signaling Technology (CST) Pathways for HTRA2
        Apoptosis and Autophagy
    Protein Stability

    2 GeneGo (Thomson Reuters) Pathways for HTRA2
        Apoptosis and survival FAS signaling cascades
    Apoptosis and survival TNFR1 signaling pathway

    2 BioSystems Pathways for HTRA2
        Apoptosis Modulation and Signaling
    Parkinsons Disease Pathway



    1 Kegg Pathway  (Kegg details for HTRA2):
        Parkinson's disease


    HTRA2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HTRA2: 
              Apoptosis 384HT in human mouse rat
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HTRA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HTRA2 (O434641, 2, 3 ENSP000002580804) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDUFA13Q9P0J01, 3EBI-517086,EBI-372742 I2D: score=1 
    XIAPP981701, 3, ENSP000003478584EBI-517086,EBI-517127 I2D: score=6 STRING: ENSP00000347858
    BIRC7Q96CA51, 3, ENSP000002171694EBI-517086,EBI-517623 I2D: score=2 STRING: ENSP00000217169
    USP7Q930092, 3, ENSP000003435354MINT-2872222 I2D: score=3 STRING: ENSP00000343535
    BIRC3Q134893, ENSP000002634644I2D: score=5 STRING: ENSP00000263464
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis TAS10873535
    GO:0006672ceramide metabolic process IEA--
    GO:0007005mitochondrion organization IEA--
    GO:0007628adult walking behavior IEA--
    GO:0008344adult locomotory behavior ----

    HTRA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HTRA2

    1 Novoseek inferred chemical compound relationship for HTRA2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 61.5 15 16520551 (3), 18231652 (2), 18786092 (2), 17557079 (1) (see all 9)



    HTRA2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HTRA2 gene (2 alternative transcripts): 
    NM_013247.4  NM_145074.2  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000258080(uc002smi.1 uc002smj.1 uc002smk.1 uc002sml.1)
    ENST00000462909 ENST00000467961 ENST00000484881 ENST00000352222 ENST00000437202
    ENST00000484352 ENST00000465521 ENST00000482205 ENST00000482331(uc010ffl.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HTRA2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HTRA2 (see all 24):
    hsa-miR-485-5p hsa-miR-15a hsa-miR-885-5p hsa-miR-410 hsa-miR-27b* hsa-miR-424 hsa-miR-28-5p hsa-miR-3649
    SwitchGear 3'UTR luciferase reporter plasmidHTRA2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HTRA2
    Predesigned siRNA for gene silencing in human, mouse, rat HTRA2
    Clone
    Products:
         
    OriGene clones in human, mouse for HTRA2 (see all 13)
    OriGene ORF clones in mouse, rat for HTRA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HTRA2 (NM_013247)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HTRA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTRA2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HTRA2
    OriGene qSTAR qPCR primer pairs in human, mouse for HTRA2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HTRA2
      QuantiTect SYBR Green Assays in human, mouse, rat HTRA2
      QuantiFast Probe-based Assays in human, mouse, rat HTRA2

    Selected AceView cDNA sequences (see all 239):

    BM697987 BQ010811 AA385242 AA781400 BC000096 BU753477 AA741018 CB241612 
    CK300191 AA687369 AF141306 AI833313 CR611201 CA407445 AA506052 AI221425 
    BM707776 BQ926185 AF141305 CR606695 BM987637 BQ188720 BQ773725 CR611713 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HTRA2 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:              -     -                                                               
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:              -     -     -                                                         


    ECgene alternative splicing isoforms for HTRA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HTRA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTACTCAT
    HTRA2 Expression
    About this image

    HTRA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HTRA2 Protein Expression

    UniProtKB/Swiss-Prot: HTRA2_HUMAN, O43464
    Tissue specificity: Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HTRA2: 
              Apoptosis 384HT in human mouse rat
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HTRA2
    OriGene qSTAR qPCR primer pairs in human, mouse for HTRA2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HTRA2
    QuantiTect SYBR Green Assays in human, mouse, rat HTRA2
    QuantiFast Probe-based Assays in human, mouse, rat HTRA2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTRA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for HTRA2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Htra21 , 5 HtrA serine peptidase 21, 5 86.1(n)1
    84.93(a)1
      6 (35.94 cM)5
    647041  NM_019752.31  NP_062726.31 
     830512665 
    chicken
    (Gallus gallus)
    Aves HTRA21 HtrA serine peptidase 2 71.05(n)
    75.96(a)
      395990  XM_423666.4  XP_423666.3 
    lizard
    (Anolis carolinensis)
    Reptilia HTRA26
    HtrA serine peptidase 2
    70(a)
    1 ↔ 1
    GL343867.1(59544-68200)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.110962 Transcribed sequence with weak similarity to protein more 77.53(n)    BX688550.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003309191 serine protease HTRA2, mitochondrial-like 65.15(n)
    69.89(a)
      100330919  XM_005160985.1  XP_005161042.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta HtrA21 HtrA2 55.74(n)
    53.57(a)
      41756  NM_001275636.1  NP_001262565.1 


    ENSEMBL Gene Tree for HTRA2 (if available)
    TreeFam Gene Tree for HTRA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HTRA2 gene
    HTRA12  HTRA42  HTRA32  
    3 SIMAP similar genes for HTRA2 using alignment to 2 protein entries:     HTRA2_HUMAN (see all proteins):
    HTRA1    HTRA3    HTRA4

    HTRA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HTRA2 (see all 135)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs724705451,2,4
    Parkinson disease 13 (PARK13)4--see VAR_0273502 mis40--------
    rs1853979671,2
    C--74625825(+) GCCACA/CCTTTC 2 -- us2k10--------
    rs1997590351,2
    --74625890(+) TGACTC/TTCTGA 2 -- us2k10--------
    rs2018355601,2
    C--74626057(+) AGGCCA/GAAAAA 2 -- us2k10--------
    rs2020719431,2
    --74626068(+) AAAAAA/CCCCCA 2 -- us2k10--------
    rs1132041691,2
    C--74626100(+) CACATA/GCCTGA 2 -- us2k10--------
    rs1123239241,2
    C--74626101(+) ACATAC/GCTGAC 2 -- us2k10--------
    rs1387522231,2
    C--74626113(+) GGGGGC/TGCAAT 2 -- us2k10--------
    rs743724311,2
    C,F--74626141(+) CTTCAT/CGTGCT 2 -- us2k11Minor allele frequency- C:0.02WA 118
    rs747244351,2
    C--74626183(+) TGTCTA/GGCCCA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for HTRA2 (74756504 - 74760683 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for HTRA2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv458185CNV Loss19166990
    nsv515851CNV Loss19592680
    dgv4166n71CNV Loss21882294
    dgv1199e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): HTRA2
    Locus Specific Mutation Databases (LSDB): HTRA2

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing HTRA2
    DNA2.0 Custom Variant and Variant Library Synthesis for HTRA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606441   
    OMIM disorders: 610297  
    UniProtKB/Swiss-Prot: HTRA2_HUMAN, O43464
  • Parkinson disease 13 (PARK13) [MIM:610297]: A complex neurodegenerative disorder characterized by
    bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant
    response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia
    nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons
    in various areas of the brain. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • Selected diseases for HTRA2 (see all 38):    
    About MalaCards
    parkinson disease 13    htra2-related parkinson disease    ophthalmomyiasis    parkinson disease 1
    clear cell renal cell carcinoma    cytomegalovirus infection    parkinson's disease    tremor
    diffuse large b-cell lymphoma    b-cell lymphomas    renal cell carcinoma    wilms tumor
    lateral sclerosis    amyotrophic lateral sclerosis    huntington's disease    acute leukemia
    pneumonia    prostate cancer    ischemia    myocardial infarction

    3 diseases from the University of Copenhagen DISEASES database for HTRA2:
    Parkinson's disease     Ophthalmomyiasis     Myocardial infarction

    HTRA2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for HTRA2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 10.7 1 17207090 (1)
    cancer 3.92 3 18231652 (1), 18259191 (1), 19424634 (1)

    GeneTests: HTRA2
    GeneReviews: HTRA2
    Genetic Association Database (GAD): HTRA2
    Human Genome Epidemiology (HuGE) Navigator: HTRA2 (9 documents)

    Export disorders for HTRA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HTRA2 gene, integrated from 10 sources (see all 139):
    (articles sorted by number of sources associating them with HTRA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia. (PubMed id 10644717)1, 2, 3, 9 Faccio L....Zervos A.S. (J. Biol. Chem. 2000)
    2. Genetic variability in the mitochondrial serine protease HTRA2 contributes to risk for Parkinson disease. (PubMed id 18401856)1, 2, 4, 9 Bogaerts V.... Van Broeckhoven C. (Hum. Mutat. 2008)
    3. Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response. (PubMed id 10971580)1, 2, 3 Gray C.W.... Creasy C.L. (Eur. J. Biochem. 2000)
    4. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. (PubMed id 11583623)1, 2, 9 Suzuki Y.... Takahashi R. (Mol. Cell 2001)
    5. Tissue-specific splicing of Omi stress-regulated endoprotease leads to an inactive protease with a modified PDZ motif. (PubMed id 10995577)1, 2, 9 Faccio L.... Zervos A.S. (Genomics 2000)
    6. A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease. (PubMed id 20036034)1, 4 KrA1ger R....Maraganore D.M. (Neurobiol. Aging 2011)
    7. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    8. Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease? (PubMed id 19224617)1, 4 Sutherland G.T....Mellick G.D. (Mov. Disord. 2009)
    9. THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death. (PubMed id 19502560)1, 2 Balakrishnan M.P....Zervos A.S. (Am. J. Physiol. 2009)
    10. Genetic variation of Omi/HtrA2 and Parkinson's disease. (PubMed id 18790661)1, 4 Ross O.A....Farrer M.J. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 27429 HGNC: 14348 AceView: PRSS25 Ensembl:ENSG00000115317 euGenes: HUgn27429
    ECgene: HTRA2 Kegg: 27429 H-InvDB: HTRA2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HTRA2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HTRA2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HTRA2 gene:
    Search GeneIP for patents involving HTRA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for HTRA2 (HTRA2/Omi)   Browse Cell Culture Products  
     ELISAs for HTRA2 (HTRA2/Omi)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for HTRA2 (HTRA2/Omi)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for HTRA2 (HTRA2/Omi)  
     OriGene Antibodies for HTRA2   OriGene RNAi products in human, mouse, rat for HTRA2  
     OriGene qPCR primer pairs and template standards for HTRA2   OriGene Protein Over-expression Lysate for HTRA2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HTRA2  
     OriGene qSTAR qPCR primer pairs in human, mouse for HTRA2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for HTRA2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HTRA2   OriGene Custom Protein Services for HTRA2  

     
     
     Block miRNA regulation of human, mouse, rat HTRA2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HTRA2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HTRA2 Predesigned siRNA for gene silencing in human, mouse, rat HTRA2
     QuantiFast Probe-based Assays in human, mouse, rat HTRA2 QuantiTect SYBR Green Assays in human, mouse, rat HTRA2
     PCR Arrays including human, mouse, rat HTRA2 Search Chromatin IP Primers for HTRA2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HTRA2  GeneGlobe Interaction Network for HTRA2
     Regulatory tfbs in HTRA2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for HTRA2 GenScript cDNA clones with any tag delivered in your preferred vector for HTRA2
     GenScript Custom Assay Services for HTRA2 GenScript Custom overexpressing Cell Line Services for HTRA2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for HTRA2 

     Search Tocris compounds for HTRA2
     Proteins for HTRA2
     Browse Sino Biological Cell Lysates
     cDNA Clones for HTRA2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HTRA2 antibodies
     HTRA2 proteins
     Antibodies for HTRA2
     See all of Abcam's Antibodies, Kits and Proteins for HTRA2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for HTRA2
     Proteins for HTRA2
     Antibodies for HTRA2
     ELISAs for HTRA2
     CLIAs for HTRA2



     Browse ESI BIO Cell Lines and PureStem Progenitors for HTRA2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HTRA2
     SwitchGear 3'UTR luciferase reporter plasmids for HTRA2
     SwitchGear Promoter luciferase reporter plasmids for HTRA2
     ThermoFisher Antibody for HTRA2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HTRA2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HTRA2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HTRA2
     LSBio Antibodies in human, mouse, rat for HTRA2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HTRA2 gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4