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Aliases for HTRA2 Gene

Aliases for HTRA2 Gene

  • HtrA Serine Peptidase 2 2 3 5
  • High Temperature Requirement Protein A2 3 4
  • Omi Stress-Regulated Endoprotease 3 4
  • Serine Proteinase OMI 3 4
  • Protease, Serine, 25 2 3
  • Serine Protease 25 3 4
  • EC 3.4.21.108 4 61
  • PRSS25 3 4
  • OMI 3 4
  • Serine Protease HTRA2, Mitochondrial 3
  • HtrA-Like Serine Protease 3
  • PARK13 3
  • MGCA8 3
  • HtrA2 4

External Ids for HTRA2 Gene

Previous HGNC Symbols for HTRA2 Gene

  • PRSS25

Previous GeneCards Identifiers for HTRA2 Gene

  • GC02P074669
  • GC02P074610
  • GC02P074757
  • GC02P074492

Summaries for HTRA2 Gene

Entrez Gene Summary for HTRA2 Gene

  • This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

GeneCards Summary for HTRA2 Gene

HTRA2 (HtrA Serine Peptidase 2) is a Protein Coding gene. Diseases associated with HTRA2 include Parkinson Disease 13 and Htra2-Related Parkinson Disease. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Parkinsons Disease Pathway. GO annotations related to this gene include serine-type endopeptidase activity and unfolded protein binding. An important paralog of this gene is HTRA1.

UniProtKB/Swiss-Prot for HTRA2 Gene

  • Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.

Gene Wiki entry for HTRA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HTRA2 Gene

Genomics for HTRA2 Gene

Regulatory Elements for HTRA2 Gene

Enhancers for HTRA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F074196 0.2 ENCODE 12.4 -330.6 -330630 3.9 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 ENSG00000273245 DUSP11 DGUOK-AS1 PCGF1 SEMA4F BOLA3-AS1 C2orf81 SLC4A5 MOGS KRT18P26
GH02F074177 0.8 ENCODE 12.4 -350.9 -350861 2.3 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF207 SP3 SP5 DUSP11 BOLA3-AS1 ENSG00000273245 DGUOK-AS1 LOC107985899 MOGS PCGF1 HTRA2 BOLA3 MTHFD2
GH02F074487 0.2 ENCODE 11.8 -39.0 -39039 4.9 PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 LBX2 HTRA2 AUP1 DQX1 MOGS TLX2 WBP1 DOK1 LOXL3 GC02P074500
GH02F074550 0.2 ENCODE 11.7 +21.4 21396 0.0 FOXA3 YBX1 AUP1 HTRA2 DQX1 MRPL53 WBP1 MOGS TLX2 PCGF1 DOK1 LOXL3
GH02F074551 0.4 ENCODE 11.7 +24.3 24345 5.6 HDGF PKNOX1 WRNIP1 ZFP64 SIN3A ARID4B YBX1 DMAP1 ZNF143 ZNF207 LBX2-AS1 AUP1 HTRA2 TLX2 PCGF1 DQX1 MRPL53 WBP1 MOGS M1AP
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HTRA2 on UCSC Golden Path with GeneCards custom track

Promoters for HTRA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000121038 723 2601 HDGF ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9

Genomic Location for HTRA2 Gene

Chromosome:
2
Start:
74,529,377 bp from pter
End:
74,533,556 bp from pter
Size:
4,180 bases
Orientation:
Plus strand

Genomic View for HTRA2 Gene

Genes around HTRA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HTRA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HTRA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HTRA2 Gene

Proteins for HTRA2 Gene

  • Protein details for HTRA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43464-HTRA2_HUMAN
    Recommended name:
    Serine protease HTRA2, mitochondrial
    Protein Accession:
    O43464
    Secondary Accessions:
    • Q9HBZ4
    • Q9P0Y3
    • Q9P0Y4

    Protein attributes for HTRA2 Gene

    Size:
    458 amino acids
    Molecular mass:
    48841 Da
    Quaternary structure:
    • Homotrimer. Interacts with MXI2. Interacts with THAP5 under apoptotic conditions. The mature protein, but not the precursor, binds to BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Interacts with BIRC6/bruce.

    Three dimensional structures from OCA and Proteopedia for HTRA2 Gene

    Alternative splice isoforms for HTRA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HTRA2 Gene

Selected DME Specific Peptides for HTRA2 Gene

O43464:
  • GSPFALQNT
  • GNSGGPL
  • NFIADVVEK

Post-translational modifications for HTRA2 Gene

Other Protein References for HTRA2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HTRA2 (HTRA2)

Domains & Families for HTRA2 Gene

Suggested Antigen Peptide Sequences for HTRA2 Gene

Graphical View of Domain Structure for InterPro Entry

O43464

UniProtKB/Swiss-Prot:

HTRA2_HUMAN :
  • The mature N-terminus is involved in the interaction with XIAP.
  • Belongs to the peptidase S1C family.
Domain:
  • The mature N-terminus is involved in the interaction with XIAP.
  • The PDZ domain mediates interaction with MXI2.
  • Contains 1 PDZ (DHR) domain.
Family:
  • Belongs to the peptidase S1C family.
genes like me logo Genes that share domains with HTRA2: view

Function for HTRA2 Gene

Molecular function for HTRA2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues.
UniProtKB/Swiss-Prot Function:
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.

Enzyme Numbers (IUBMB) for HTRA2 Gene

Gene Ontology (GO) - Molecular Function for HTRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity IEA,TAS 10873535
GO:0005515 protein binding IPI 10971580
GO:0008233 peptidase activity IEA,IMP 24709290
GO:0008236 serine-type peptidase activity TAS 18309324
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with HTRA2: view
genes like me logo Genes that share phenotypes with HTRA2: view

Human Phenotype Ontology for HTRA2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HTRA2 Gene

MGI Knock Outs for HTRA2:

Animal Model Products

miRNA for HTRA2 Gene

miRTarBase miRNAs that target HTRA2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HTRA2

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for HTRA2 Gene

Localization for HTRA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HTRA2 Gene

Mitochondrion intermembrane space. Mitochondrion membrane; Single-pass membrane protein. Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HTRA2 Gene COMPARTMENTS Subcellular localization image for HTRA2 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
mitochondrion 5
nucleus 5
cytoskeleton 4
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for HTRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IDA 24798695
GO:0005634 nucleus IDA 10971580
GO:0005739 mitochondrion TAS 18309324
GO:0005758 mitochondrial intermembrane space IEA,IDA 15044455
GO:0005783 endoplasmic reticulum NAS 10995577
genes like me logo Genes that share ontologies with HTRA2: view

Pathways & Interactions for HTRA2 Gene

genes like me logo Genes that share pathways with HTRA2: view

Pathways by source for HTRA2 Gene

1 GeneTex pathway for HTRA2 Gene
1 Cell Signaling Technology pathway for HTRA2 Gene
2 BioSystems pathways for HTRA2 Gene

SIGNOR curated interactions for HTRA2 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for HTRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,TAS 10873535
GO:0006672 ceramide metabolic process IEA --
GO:0006915 apoptotic process IEA --
GO:0007005 mitochondrion organization IEA --
GO:0007568 aging IEA --
genes like me logo Genes that share ontologies with HTRA2: view

Drugs & Compounds for HTRA2 Gene

(1) Drugs for HTRA2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HTRA2: view

Transcripts for HTRA2 Gene

Unigene Clusters for HTRA2 Gene

HtrA serine peptidase 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HTRA2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HTRA2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1: - -
SP2:
SP3:
SP4:
SP5: - - -
SP6:

Relevant External Links for HTRA2 Gene

GeneLoc Exon Structure for
HTRA2
ECgene alternative splicing isoforms for
HTRA2

Expression for HTRA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HTRA2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HTRA2 Gene



Protein tissue co-expression partners for HTRA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HTRA2 Gene:

HTRA2

SOURCE GeneReport for Unigene cluster for HTRA2 Gene:

Hs.744841

mRNA Expression by UniProt/SwissProt for HTRA2 Gene:

O43464-HTRA2_HUMAN
Tissue specificity: Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.
genes like me logo Genes that share expression patterns with HTRA2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for HTRA2 Gene

Orthologs for HTRA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HTRA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HTRA2 34 35
  • 99.17 (n)
dog
(Canis familiaris)
Mammalia HTRA2 34 35
  • 90.6 (n)
cow
(Bos Taurus)
Mammalia HTRA2 34 35
  • 89.96 (n)
oppossum
(Monodelphis domestica)
Mammalia HTRA2 35
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Htra2 34
  • 86.17 (n)
mouse
(Mus musculus)
Mammalia Htra2 34 16 35
  • 86.1 (n)
chicken
(Gallus gallus)
Aves HTRA2 34 35
  • 71.05 (n)
lizard
(Anolis carolinensis)
Reptilia HTRA2 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11096 34
zebrafish
(Danio rerio)
Actinopterygii HTRA2 (12 of 31) 35
  • 69 (a)
OneToMany
HTRA2 (16 of 31) 35
  • 69 (a)
OneToMany
HTRA2 (26 of 31) 35
  • 69 (a)
OneToMany
HTRA2 (1 of 31) 35
  • 68 (a)
OneToMany
HTRA2 (13 of 31) 35
  • 68 (a)
OneToMany
HTRA2 (18 of 31) 35
  • 68 (a)
OneToMany
HTRA2 (24 of 31) 35
  • 68 (a)
OneToMany
HTRA2 (28 of 31) 35
  • 68 (a)
OneToMany
HTRA2 (3 of 31) 35
  • 68 (a)
OneToMany
HTRA2 (6 of 31) 35
  • 68 (a)
OneToMany
HTRA2 (7 of 31) 35
  • 68 (a)
OneToMany
HTRA2 (10 of 31) 35
  • 67 (a)
OneToMany
HTRA2 (15 of 31) 35
  • 67 (a)
OneToMany
HTRA2 (31 of 31) 35
  • 67 (a)
OneToMany
HTRA2 (11 of 31) 35
  • 66 (a)
OneToMany
HTRA2 (14 of 31) 35
  • 66 (a)
OneToMany
HTRA2 (17 of 31) 35
  • 66 (a)
OneToMany
HTRA2 (2 of 31) 35
  • 66 (a)
OneToMany
HTRA2 (27 of 31) 35
  • 66 (a)
OneToMany
HTRA2 (5 of 31) 35
  • 66 (a)
OneToMany
LOC100330919 34
  • 65.15 (n)
HTRA2 (23 of 31) 35
  • 65 (a)
OneToMany
HTRA2 (29 of 31) 35
  • 65 (a)
OneToMany
HTRA2 (9 of 31) 35
  • 64 (a)
OneToMany
HTRA2 (8 of 31) 35
  • 63 (a)
OneToMany
HTRA2 (30 of 31) 35
  • 61 (a)
OneToMany
HTRA2 (20 of 31) 35
  • 60 (a)
OneToMany
HTRA2 (25 of 31) 35
  • 60 (a)
OneToMany
HTRA2 (22 of 31) 35
  • 59 (a)
OneToMany
HTRA2 (19 of 31) 35
  • 55 (a)
OneToMany
HTRA2 (21 of 31) 35
  • 52 (a)
OneToMany
HTRA2 (4 of 31) 35
  • 38 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000240 34
  • 59.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta HtrA2 34 35
  • 55.74 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
Species where no ortholog for HTRA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HTRA2 Gene

ENSEMBL:
Gene Tree for HTRA2 (if available)
TreeFam:
Gene Tree for HTRA2 (if available)

Paralogs for HTRA2 Gene

Paralogs for HTRA2 Gene

(3) SIMAP similar genes for HTRA2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HTRA2: view

Variants for HTRA2 Gene

Sequence variations from dbSNP and Humsavar for HTRA2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_046135 Parkinson disease 13 (PARK13) [MIM:610297]
rs869025234 Uncertain significance 74,530,805(+) AACGC(A/T)GAGGA nc-transcript-variant, upstream-variant-2KB, reference, missense
rs387906942 other 74,530,433(+) CTTCT(C/G)CCCGG intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense
rs72470544 other 74,530,427(+) CGCCC(G/T)CTTCT intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense
rs72470545 other 74,532,698(+) TCCTG(A/G)GCTCC intron-variant, nc-transcript-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HTRA2 Gene

Variant ID Type Subtype PubMed ID
esv2759061 CNV loss 17122850
nsv458185 CNV loss 19166990
nsv515851 CNV loss 19592680
nsv582214 CNV loss 21841781

Variation tolerance for HTRA2 Gene

Residual Variation Intolerance Score: 31.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HTRA2 Gene

Human Gene Mutation Database (HGMD)
HTRA2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HTRA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HTRA2 Gene

Disorders for HTRA2 Gene

MalaCards: The human disease database

(8) MalaCards diseases for HTRA2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
parkinson disease 13
  • park13
htra2-related parkinson disease
  • parkinson disease 13
ophthalmomyiasis
  • ocular myiasis
anteroseptal myocardial infarction
tremor
- elite association - COSMIC cancer census association via MalaCards
Search HTRA2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

HTRA2_HUMAN
  • Parkinson disease 13 (PARK13) [MIM:610297]: A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. {ECO:0000269 PubMed:15961413, ECO:0000269 PubMed:18401856}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for HTRA2

Genetic Association Database (GAD)
HTRA2
Human Genome Epidemiology (HuGE) Navigator
HTRA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HTRA2
genes like me logo Genes that share disorders with HTRA2: view

No data available for Genatlas for HTRA2 Gene

Publications for HTRA2 Gene

  1. Genetic variability in the mitochondrial serine protease HTRA2 contributes to risk for Parkinson disease. (PMID: 18401856) Bogaerts V. … Van Broeckhoven C. (Hum. Mutat. 2008) 3 4 22 46 64
  2. Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia. (PMID: 10644717) Faccio L. … Zervos A.S. (J. Biol. Chem. 2000) 2 3 4 22 64
  3. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. (PMID: 11583623) Suzuki Y. … Takahashi R. (Mol. Cell 2001) 3 4 22 64
  4. Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response. (PMID: 10971580) Gray C.W. … Creasy C.L. (Eur. J. Biochem. 2000) 2 3 4 64
  5. Tissue-specific splicing of Omi stress-regulated endoprotease leads to an inactive protease with a modified PDZ motif. (PMID: 10995577) Faccio L. … Zervos A.S. (Genomics 2000) 3 4 22 64

Products for HTRA2 Gene

Sources for HTRA2 Gene

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